An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of alpha-mannosidase (EC 3.2.1.24).
ChEBI ID: 191196
| Member | Definition | Class |
|---|---|---|
| mannostatin a | An amino cyclitol that is cyclopentane substituted by hydroxy groups at positions 1, 2 and 3, by an amino group at positon 4, and by a methylsulfanediyl group at position 5 (the 1R,2R,3R,4S,5R-stereoisomer). It is isolated from the soil bacterium Streptoverticillium verticillium. | mannostatin A |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (13.33) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 7 (46.67) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (6.25%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 15 (93.75%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alpha-mannosidase 2 | Drosophila melanogaster (fruit fly) | Ki | 0.0360 | 1 | 1 |
| Chain A, alpha-mannosidase II | Drosophila melanogaster (fruit fly) | Ki | 0.0360 | 1 | 2 |
| Mannosyl-oligosaccharide alpha-1,2-mannosidase IA | Drosophila melanogaster (fruit fly) | IC50 | 0.1500 | 1 | 1 |