Page last updated: 2024-08-05 15:46:36

EC 2.7.1.105 (6-phosphofructo-2-kinase) inhibitor

An EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of 6-phosphofructo-2-kinase (EC 2.7.1.105).

ChEBI ID: 144387

Members (1)

MemberDefinitionClass
3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-oneA member of the class of pyridines that is pyridine substituted by a 3-oxo-3-(pyridin-4-yl)prop-1-en-1-yl group at position 3. An inhibitor of PFKFB3 kinase, an enzyme with a key role in glycolysis.3PO

Research

Studies (17)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (5.88)29.6817
2010's12 (70.59)24.3611
2020's4 (23.53)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.88%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (94.12%)84.16%

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3Homo sapiens (human)IC5049.300033
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3Homo sapiens (human)Ki25.100011