An EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor that interferes with the action of tryptophan 2,3-dioxygenase (EC 1.13.11.11).
ChEBI ID: 131961
| Member | Definition | Class | Studies | Trials |
|---|---|---|---|---|
| 680c91 | A fluoroindole that is 6-fluoroindole in which the hydrogen at position 3 has been replaced by a 2-(pyridin-3-yl)vinyl group (trans configuration). It is a selective inhibitor of tryptophan 2,3-dioxygenase (TDO), which directs the conversion of trypophan to kynurenin. | fluoroindole; | 27 | 0 | |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) | IC50 | 413.8000 | 2 | 2 |
| Tryptophan 2,3-dioxygenase | Rattus norvegicus (Norway rat) | IC50 | 0.0500 | 1 | 1 |
| Indoleamine 2,3-dioxygenase 1 | Mus musculus (house mouse) | IC50 | 80.0000 | 1 | 1 |
| Tryptophan 2,3-dioxygenase | Homo sapiens (human) | IC50 | 0.4693 | 9 | 9 |
| Tryptophan 2,3-dioxygenase | Homo sapiens (human) | Ki | 0.4550 | 2 | 2 |
| Tryptophan 2,3-dioxygenase | Mus musculus (house mouse) | IC50 | 1.2300 | 2 | 2 |
| Studies | Pre-1990 | 1990's | 2000's | 2010's | Post-2020 |
|---|---|---|---|---|---|
| 7 | 0 | 0 | 0 | 5 | 2 |