A protein phosphatase methylesterase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y570]
PME-1;
EC 3.1.1.89
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| amz 30 | Homo sapiens (human) | IC50 | 2.0500 | 2 | 2 |
This protein enables 10 target(s):
| Target | Category | Definition |
|---|---|---|
| protein phosphatase inhibitor activity | molecular function | Binds to and stops, prevents or reduces the activity of a protein phosphatase. [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| protein phosphatase regulator activity | molecular function | Binds to and modulates the activity of a protein phosphatase. [GOC:ai] |
| protein kinase binding | molecular function | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl] |
| protein phosphatase binding | molecular function | Binding to a protein phosphatase. [GOC:jl] |
| cadherin binding | molecular function | Binding to cadherin, a type I membrane protein involved in cell adhesion. [GOC:bf] |
| protein phosphatase 2A binding | molecular function | Binding to protein phosphatase 2A. [GOC:ai] |
| protein C-terminal methylesterase activity | molecular function | Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol. [PMID:10318862, PMID:8650216] |
| lncRNA binding | molecular function | Binding to a long noncoding RNA (lncRNA). [PMID:25578728] |
| protein methylesterase activity | molecular function | Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol. [GOC:ai] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| G2/M transition of mitotic cell cycle | biological process | The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex. [GOC:mtg_cell_cycle] |
| protein demethylation | biological process | The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. [GOC:mah] |