Tryptophan 5-hydroxylase 2

A tryptophan 5-hydroxylase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IWU9]

EC 1.14.16.4;
Neuronal tryptophan hydroxylase;
Tryptophan 5-monooxygenase 2

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
telotristat	Homo sapiens (human)	IC50	0.7100	1	1

This protein enables 2 target(s):

Target	Category	Definition
tryptophan 5-monooxygenase activity	molecular function	Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O. [EC:1.14.16.4]
iron ion binding	molecular function	Binding to an iron (Fe) ion. [GOC:ai]

This protein is located in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is active in 1 target(s):

Target	Category	Definition
neuron projection	cellular component	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]

This protein is involved in 2 target(s):

Target	Category	Definition
aromatic amino acid metabolic process	biological process	The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). [GOC:go_curators]
serotonin biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. [GOC:jl, ISBN:0198506732]