Assay ID | Title | Year | Journal | Article |
AID678695 | Inhibition of human adenosine A3 receptor at 10 uM | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678698 | Inhibition of human ERG at 10 uM | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678692 | Activation of KCNQ2 channel expressed in CHO cells assessed as depolarization-induced thallium influx up to 30 uM after 3 mins by patch clamp assay relative to control | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678691 | Selectivity ratio of EC50 for KCNQ4 channel to EC50 for Kv7.1 channel | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678694 | Inhibition of human ERG expressed in CHO cells after 3 mins by patch clamp assay | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678683 | Drug metabolism in human liver microsomes assessed as methoxy-O-demethylation by mass spectrophotometry | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678690 | Selectivity ratio of EC50 for KCNQ2 channel to EC50 for Kv7.1 channel | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678701 | Fraction unbound in human plasma | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678702 | Fraction unbound in rat plasma | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678696 | Inhibition of rat L-type calcium channel at 10 uM | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678689 | Activation of KCNQ4 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay relative to control | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678685 | Drug metabolism in human liver microsomes assessed as tolyl-oxidation by mass spectrophotometry | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678688 | Activation of KCNQ2 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay relative to control | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678687 | Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay relative to control | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678686 | Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678704 | Intrinsic clearance in rat liver microsomes | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678697 | Inhibition of human CB1 receptor at 10 uM | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678699 | Inhibition of human 5HT2B receptor at 10 uM | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678693 | Activation of KCNQ4 channel expressed in CHO cells assessed as depolarization-induced thallium influx up to 30 uM after 3 mins by patch clamp assay relative to control | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678705 | Drug metabolism in rat liver microsomes assessed as methoxy-O-demethylation by mass spectrophotometry | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678703 | Intrinsic clearance in human liver microsomes | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678684 | Drug metabolism in rat liver microsomes assessed as tolyl-oxidation by mass spectrophotometry | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID678700 | Inhibition of human DAT at 10 uM | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1346723 | Human Kv7.1 (Voltage-gated potassium channels) | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |