Page last updated: 2024-12-09

1-(3-chlorophenyl)-3-(2-phenoxyphenyl)thiourea

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1-(3-chlorophenyl)-3-(2-phenoxyphenyl)thiourea is a synthetic compound with the following structural formula:

**[Image of the compound's structural formula]**

This compound belongs to a family of molecules called thioureas. Thioureas are organic compounds containing the functional group C(=S)NH2, which is characterized by a sulfur atom double-bonded to a carbon atom and single-bonded to a nitrogen atom.

**Why is 1-(3-chlorophenyl)-3-(2-phenoxyphenyl)thiourea important for research?**

While this specific compound might not be widely studied, thioureas in general are of significant interest in research due to their diverse biological activities. Here are some reasons why:

* **Antimicrobial Activity:** Thioureas have been shown to exhibit antimicrobial activity against various bacteria, fungi, and viruses. They can interfere with the growth and survival of these microorganisms.
* **Anti-inflammatory Properties:** Some thioureas have been found to possess anti-inflammatory properties, potentially making them useful in treating conditions like arthritis.
* **Antioxidant Activity:** Thioureas can act as antioxidants, protecting cells from damage caused by free radicals.
* **Anti-cancer Activity:** Certain thioureas have been explored for their potential anti-cancer activity. They can interact with DNA, inhibit enzyme activity, and induce apoptosis (programmed cell death) in cancer cells.
* **Potential for Drug Development:** The diverse biological activities of thioureas make them attractive candidates for drug development. Researchers are investigating their potential in treating a range of diseases, including infections, inflammation, and cancer.

**Specific to 1-(3-chlorophenyl)-3-(2-phenoxyphenyl)thiourea, its importance likely depends on the specific research context:**

* It could be used as a starting point for the synthesis of other, potentially more potent thiourea derivatives.
* It might be investigated for its own biological activity, especially if it possesses unique structural features compared to other thioureas.
* It could be studied as a model compound to understand the structure-activity relationship of thioureas.

**To fully understand the importance of this specific compound, more information is needed about the research project or study it is involved in.**

Cross-References

ID SourceID
PubMed CID1288168
CHEMBL ID1451017
CHEBI ID122158

Synonyms (11)

Synonym
smr000199376
n-(3-chlorophenyl)-n'-(2-phenoxyphenyl)thiourea
MLS000580489
STK133805
1-(3-chlorophenyl)-3-(2-phenoxyphenyl)thiourea
CHEBI:122158
AKOS003711845
HMS2156O04
HMS3315M17
CHEMBL1451017
Q27210803
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (19)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Ferritin light chainEquus caballus (horse)Potency28.18385.623417.292931.6228AID485281
glp-1 receptor, partialHomo sapiens (human)Potency14.12540.01846.806014.1254AID624417
TDP1 proteinHomo sapiens (human)Potency24.84460.000811.382244.6684AID686978; AID686979
Microtubule-associated protein tauHomo sapiens (human)Potency19.95260.180013.557439.8107AID1468
Smad3Homo sapiens (human)Potency35.48130.00527.809829.0929AID588855
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency25.11890.011212.4002100.0000AID1030
PINK1Homo sapiens (human)Potency50.11872.818418.895944.6684AID624263
67.9K proteinVaccinia virusPotency28.18380.00018.4406100.0000AID720580
ParkinHomo sapiens (human)Potency50.11870.819914.830644.6684AID624263
IDH1Homo sapiens (human)Potency16.36010.005210.865235.4813AID686970
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency28.18380.035520.977089.1251AID504332
polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)Potency22.38721.000012.232631.6228AID1452
chromobox protein homolog 1Homo sapiens (human)Potency4.46680.006026.168889.1251AID540317
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency23.10930.00419.984825.9290AID504444
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency22.74070.00798.23321,122.0200AID2546; AID2551
gemininHomo sapiens (human)Potency20.59620.004611.374133.4983AID624296
neuropeptide S receptor isoform AHomo sapiens (human)Potency25.11890.015812.3113615.5000AID1461
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
G protein-activated inward rectifier potassium channel 2Homo sapiens (human)POTENCY_uM8.09112.25189.697330.0000AID623909
G protein-activated inward rectifier potassium channel 1Homo sapiens (human)POTENCY_uM8.09112.25189.697330.0000AID623909
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (10)

Processvia Protein(s)Taxonomy
potassium ion transportG protein-activated inward rectifier potassium channel 2Homo sapiens (human)
regulation of monoatomic ion transmembrane transportG protein-activated inward rectifier potassium channel 2Homo sapiens (human)
potassium ion import across plasma membraneG protein-activated inward rectifier potassium channel 2Homo sapiens (human)
potassium ion transportG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
response to electrical stimulusG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
potassium ion transmembrane transportG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
regulation of heart rate by cardiac conductionG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
membrane repolarization during atrial cardiac muscle cell action potentialG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
membrane repolarization during ventricular cardiac muscle cell action potentialG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
regulation of presynaptic membrane potentialG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
ventricular cardiac muscle cell membrane repolarizationG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
potassium ion import across plasma membraneG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
regulation of monoatomic ion transmembrane transportG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (6)

Processvia Protein(s)Taxonomy
protein bindingG protein-activated inward rectifier potassium channel 2Homo sapiens (human)
G-protein activated inward rectifier potassium channel activityG protein-activated inward rectifier potassium channel 2Homo sapiens (human)
inward rectifier potassium channel activityG protein-activated inward rectifier potassium channel 2Homo sapiens (human)
inward rectifier potassium channel activityG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
protein bindingG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
G-protein activated inward rectifier potassium channel activityG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarizationG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potentialG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (8)

Processvia Protein(s)Taxonomy
Golgi apparatusG protein-activated inward rectifier potassium channel 2Homo sapiens (human)
plasma membraneG protein-activated inward rectifier potassium channel 2Homo sapiens (human)
voltage-gated potassium channel complexG protein-activated inward rectifier potassium channel 2Homo sapiens (human)
plasma membraneG protein-activated inward rectifier potassium channel 2Homo sapiens (human)
plasma membraneG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
external side of plasma membraneG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
T-tubuleG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
presynaptic membraneG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
parallel fiber to Purkinje cell synapseG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
I(KACh) inward rectifier potassium channel complexG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
voltage-gated potassium channel complexG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
plasma membraneG protein-activated inward rectifier potassium channel 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]