Page last updated: 2024-10-06

mandelate degradation to acetyl-CoA

Proteins (12)

ProteinSynonymsTaxonomy
Mandelate racemaseMR; EC 5.1.2.2Pseudomonas putida
Muconolactone Delta-isomeraseMIase; EC 5.3.3.4Pseudomonas putida
Beta-ketoadipyl-CoA thiolaseEC 2.3.1.174; 3-oxoadipyl-CoA thiolasePseudomonas putida
Benzoylformate decarboxylaseBFD; BFDC; EC 4.1.1.7Pseudomonas putida
4-hydroxy-2-oxovalerate aldolaseHOA; EC 4.1.3.39; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolasePseudomonas putida
Muconate cycloisomerase 1EC 5.5.1.1; Cis,cis-muconate lactonizing enzyme I; MLE; Muconate cycloisomerase IPseudomonas putida
3-oxoadipate CoA-transferase subunit BEC 2.8.3.6; Beta-ketoadipate:succinyl-CoA transferase subunit BPseudomonas putida
3-oxoadipate CoA-transferase subunit AEC 2.8.3.6; Beta-ketoadipate:succinyl-CoA transferase subunit APseudomonas putida
NAD(P)-dependent benzaldehyde dehydrogenaseEC 1.2.1.28; EC 1.2.1.7Pseudomonas putida
Catechol 1,2-dioxygenase Pseudomonas putida
3-oxoadipate enol-lactonase 2 Pseudomonas putida KT2440
(S)-mandelate dehydrogenaseEC 1.1.99.31; L(+)-mandelate dehydrogenase; MDHPseudomonas putida

Compounds (20)

CompoundDescription
hydronium ion
Succinate
NADH
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Flavin MononucleotideA coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
succinyl-coenzyme A
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
acetaldehydeA colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
benzaldehydeRN given refers to parent cpd; structure
Benzoate
formate
catecholRN given refers to unlabeled parent cpd
Coenzyme A
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.