Page last updated: 2024-10-06
estradiol biosynthesis I
Proteins (5)
| Protein | Synonyms | Taxonomy |
|---|
| 17-beta-hydroxysteroid dehydrogenase type 1 | 17-beta-HSD 1; EC 1.1.1.51; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; Estradiol 17-beta-dehydrogenase 1; 1.1.1.62; Placental 17-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 28C member 1 | Homo sapiens (human) |
| Cytochrome P450 2A6 | EC 1.14.13.-; 1,4-cineole 2-exo-monooxygenase; CYPIIA6; Coumarin 7-hydroxylase; Cytochrome P450 IIA3; Cytochrome P450(I) | Homo sapiens (human) |
| Aromatase | EC 1.14.14.14; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase | Homo sapiens (human) |
| 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 | 17-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; 3-keto-steroid reductase; 1.1.1.270; Dihydrotestosterone oxidoreductase; 1.1.1.210; Estradiol 17-beta-dehydrogenase 7; 1.1.1.62; Short chain dehydrogenase/reductase family 37C member 1 | Homo sapiens (human) |
| Estradiol 17-beta-dehydrogenase 11 | EC 1.1.1.62; 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-HSD 11; 17bHSD11; 17betaHSD11; 17-beta-hydroxysteroid dehydrogenase XI; 17-beta-HSD XI; 17betaHSDXI; Cutaneous T-cell lymphoma-associated antigen HD-CL-03; CTCL-associated antigen HD-CL-03; Deh | Homo sapiens (human) |
Compounds (9)
| Compound | Description |
|---|
| hydronium ion | |
| Estradiol | The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. |
| estrone | An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| 19-hydroxy-4-androstene-3,17-dione | |
| formate | |
| 19-oxo-delta(4) androstene-3,17-dione | RN given refers to unlabeled parent cpd; an estrogen prodrug |
| androstenedione | A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL. |