Page last updated: 2024-10-06

Retinoid cycle disease events

Proteins (7)

ProteinSynonymsTaxonomy
Retinaldehyde-binding protein 1Cellular retinaldehyde-binding proteinHomo sapiens (human)
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase DN-acyl phosphatidylethanolamine phospholipase D; NAPE-PLD; NAPE-hydrolyzing phospholipase D; EC 3.1.4.54Homo sapiens (human)
Long-wave-sensitive opsin 1Red cone photoreceptor pigment; Red-sensitive opsin; ROPHomo sapiens (human)
Lecithin retinol acyltransferaseEC 2.3.1.135; Phosphatidylcholine--retinol O-acyltransferaseHomo sapiens (human)
Retinol-binding protein 1Cellular retinol-binding protein; CRBP; Cellular retinol-binding protein I; CRBP-IHomo sapiens (human)
Medium-wave-sensitive opsin 1Green cone photoreceptor pigment; Green-sensitive opsin; GOPHomo sapiens (human)
Retinol dehydrogenase 12EC 1.1.1.300; All-trans and 9-cis retinol dehydrogenase; Short chain dehydrogenase/reductase family 7C member 2Homo sapiens (human)

Compounds (9)

CompoundDescription
hydronium ion
retinol
retinaldehydeA diterpene derived from the carotenoid VITAMIN A which functions as the active component of the visual cycle. It is the prosthetic group of RHODOPSIN (i.e., covalently bonded to ROD OPSIN as 11-cis-retinal). When stimulated by visible light, rhodopsin transforms this cis-isomer of retinal to the trans-isomer (11-trans-retinal). This transformation straightens-out the bend of the retinal molecule and causes a change in the shape of rhodopsin triggering the visual process. A series of energy-requiring enzyme-catalyzed reactions convert the 11-trans-retinal back to the cis-isomer.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
11-cis-Retinol
11-cis-retinal
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.