zidovudine and HIV
zidovudine has been researched along with HIV in 594 studies
*HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2. [MeSH]
Research
Studies (594)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 127 (21.38) | 18.7374 |
| 1990's | 328 (55.22) | 18.2507 |
| 2000's | 89 (14.98) | 29.6817 |
| 2010's | 39 (6.57) | 24.3611 |
| 2020's | 11 (1.85) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Balzarini, J; Bergstrom, DE; De Clercq, E; Mott, AW; Swartling, DJ | 1 |
| Crawford-Ruth, D; Maag, H; McRoberts, MJ; Prisbe, EJ; Rydzewski, RM; Verheyden, JP | 1 |
| Montgomery, JA; Riggs, RM; Secrist, JA; Tiwari, KN | 1 |
| Andries, K; Breslin, HJ; Fedde, CL; Kukla, MJ; Miranda, M; Pauwels, R; Raeymaekers, A; Scott, MK; Sherrill, RG; Van Gelder, J | 1 |
| Aoki, S; Driscoll, JS; Ford, H; Kelley, JA; Kojima, E; Mitsuya, H; Murakami, K; Shirasaka, T; Yoshioka, H | 1 |
| Aoki, S; Barchi, JJ; Driscoll, JS; Ford, H; Kelley, JA; Marquez, VE; Mitsuya, H; Shirasaka, T | 1 |
| Horwitz, JP; Kessel, D; Meltsner, BR; Palomino, E | 1 |
| Brankovan, V; Ghazzouli, I; Mansuri, MM; Martin, JC; Sterzycki, RZ | 1 |
| Bennett, SM; Nguyen-Ba, N; Ogilvie, KK | 1 |
| Hua, M; Vince, R | 1 |
| Balzarini, J; De Clercq, E; Hiebl, J; Zbiral, E | 1 |
| Clement, J; Erickson, J; Hayashi, S; Herrin, T; Kern, E; Norbeck, DW; Plattner, JJ; Rosenbrook, W; Sham, H; Swanson, R | 1 |
| Aggarwal, SK; Agrawal, KC; Gogu, SR; Rangan, SR | 1 |
| Augustyns, K; Balzarini, J; Blaton, N; De Clercq, E; De Ranter, C; Everaert, D; Janssen, G; Jie, L; Peeters, O; Van Aerschot, A | 1 |
| Bhadti, VS; Boudinot, FD; Chu, CK; Doshi, KJ; Etse, JT; Gallo, JM; Schinazi, RF | 1 |
| August, EM; Brankovan, V; Ghazzouli, I; Hitchcock, MJ; Lin, TS; Mansuri, MM; Prusoff, WH; Sommadossi, JP; Starrett, JE; Sterzycki, RZ | 1 |
| Baba, M; Balzarini, J; De Clercq, E; Herdewijn, P; Janssen, G; Pauwels, R; Van Aerschot, A | 1 |
| Chu, CK; Guo, JY; Lin, TS; Prusoff, WH; Schinazi, RF; Xiang, JN | 1 |
| Baba, M; Balzarini, J; Broder, S; De Clercq, E; Herdewijn, P; Pauwels, R; Vanderhaeghe, H | 1 |
| Baba, M; Balzarini, J; De Clercq, E; Herdewijn, P; Pauwels, R | 1 |
| Chen, MS; Gao, YS; Ghazzouli, I; Lin, TS; McLaren, C; Prusoff, WH | 1 |
| Cappellacci, L; De Montis, A; Franchetti, P; Grifantini, M; La Colla, P; Loi, AG; Piras, G; Sheikha, GA | 1 |
| Drach, JC; Kern, ER; Krawczyk, SH; Kucera, LS; Nassiri, MR; Ptak, RG; Townsend, LB; Wotring, LL | 1 |
| Balani, SK; Ciccarone, TM; Condra, JH; Emini, EA; Goldman, ME; Greenlee, WJ; Kauffman, LR; MacTough, SC; Rooney, CS; Williams, TM | 1 |
| Boulanger, WA; Chen, W; Cibulski, M; Flavin, MT; Flavin, TM; Greenwood, EM; Hughes, SH; Khilevich, A; Kucherenko, A; Lin, L; Pengsuparp, T; Pezzuto, JM; Rizzo, JD; Sheinkman, AK; Shone, RL; Vilaychack, V; Xu, ZQ | 1 |
| Bastow, KF; Cosentino, LM; Lee, KH; Wang, HK | 1 |
| Balzarini, J; Cahard, D; De Clercq, E; McGuigan, C; Sheeka, HM | 1 |
| Chang, FR; Lee, KH; Lin, JY; Wu, YC; Yang, PY | 1 |
| Aubertin, A; Beltran, T; Egron, D; Gosselin, G; Imbach, J; Lefebvre, I; Périgaud, C; Pompon, A | 1 |
| Gochfeld, DJ; Hamann, MT | 1 |
| Hong, JH; Kim, A | 1 |
| Baba, M; Cheng, YC; Dutschman, GE; Grill, SP; Hu, R; Lam, W; Paintsil, E; Tanaka, H | 1 |
| Barreca, ML; Benkestock, K; Chimirri, A; Christ, F; De Luca, L; Debyser, Z; Eneroth, A; Ferro, S; Hombrouck, A; Johansson, NG; Michiels, M; Noppe, W; Sahlberg, BL; Van Remoortel, B; Vrang, L; Witvrouw, M | 1 |
| Cecchetti, V; Daelemans, D; Manfroni, G; Massari, S; Pannecouque, C; Sabatini, S; Tabarrini, O | 1 |
| Gosselin, G; Hamann, M; Liuzzi, M; Musiu, C; Pierra, C; Sommadossi, JP; Storer, R; Vargiu, L | 1 |
| Boryski, J; Collu, G; Kraszewski, A; La Colla, P; Loddo, R; Romanowska, J; Sanna, G; Secci, B; Stawiński, J; Szymańska-Michalak, A | 1 |
| Asaftei, S; De Clercq, E | 1 |
| Ahmed, N; Bhutani, KK; Brahmbhatt, KG; Mitra, D; Sabde, S; Singh, IP | 1 |
| Azas, N; Casano, G; Dumètre, A; Hutter, S; Pannecouque, C; Robin, M | 1 |
| Chen, YG; Dong, JY; Gao, YX; Shen, KZ; Song, HC; Sun, R; Wang, CR; Xu, YB | 1 |
| Coltart, DM; Garnsey, MR; Kwiek, JJ; Matous, JA | 1 |
| Chiba, J; Hashimoto, C; Komoriya, M; Murakami, T; Narumi, T; Nomura, W; Suzuki, S; Tamamura, H; Tanaka, T; Wu, H; Yamamoto, N | 1 |
| Geng, Y; Li, Y; Liu, Y; Qiao, W; Tan, J; Wang, L; Wang, M; Wang, Q; Wang, Z; Yao, X | 1 |
| Ilina, T; Myshakina, NS; Parniak, MA; Sirivolu, VR; Vernekar, SK; Wang, Z | 1 |
| Aldern, KA; Beadle, JR; Broker, TR; Buckheit, RW; Chow, LT; Harden, EA; Hartman, T; Hostetler, KY; Keith, KA; Prichard, MN; Valiaeva, N; Yang, G; Yu, JH | 1 |
| Camarasa, MJ; de Castro, S | 1 |
| Chen, FE; Gu, SX; Liu, GY; Meng, G; Pannecouque, C; Tang, JF; Wu, FS; Xiao, T; Xu, ZQ; Zhu, YY | 1 |
| Fujino, M; Kaneko, M; Kobayakawa, T; Murakami, T; Owusu, KB; Tamamura, H; Tsuji, K; Wang, R; Yamamoto, N | 1 |
| De Clercq, E; Gao, P; Liu, X; Pannecouque, C; Song, S; Sun, L; Wang, Z; Zhan, P; Zhang, J | 1 |
| Ahmed, FA; Chen, CH; Hossain, GM; Kashiwada, Y; Lee, KH; Nakatani, M; Takahashi, S; Tanaka, N; Yoshino, Y | 1 |
| Motiee, F; Sohrabi, MR; Valaee, M | 1 |
| Behl, S; Cardenas, MC; Chakraborty, R; Enninga, EAL; Farnan, S; Gray, CM; Hamel, BL; Johnson, E; Littlefield, DR; Mejia Plazas, MC; Punia, S; Sintim-Aboagye, E; Temesgen, Z; Theiler, R | 1 |
| Eleje, GU; Ikechebelu, JI; Nwagha, UI; Okafor, HU; Ugwu, AO; Ugwu, EO; Umeh, UA | 1 |
| George, PE; Mercedes, R; Nabukeera-Barungi, N; Otto, SBJ | 1 |
| Alejandria, M; Arcangel, L; Arevalo, GM; Ching, PR; Destura, R; Dungca, NT; Leyritana, K; Lim, J; Mendoza, KAR; Palaypayon, NS; Peñalosa-Ramos, C; Salvana, EMT; Samonte, GMJ; Schwem, BE; Solante, R; Tactacan-Abrenica, RJ; Telan, E; Tonga, AD; Trinidad, LF | 1 |
| Jianwei, L; Menghua, W; Qinwei, Y; Xin, Z; Yu, Z | 1 |
| Basu, A; Biswas, A; Das, BK; Nischal, N; Soneja, M; Sood, R; Wig, N | 1 |
| Joshy, KS; Laly, AP; Nandakumar, K; Sabu, T; Snigdha, S; Susan, MA | 1 |
| Chen, X; Fairley, CK; He, J; Jing, J; Mao, L; Sasadeusz, J; Su, S; Wei, X; Zeng, H; Zhang, L | 1 |
| Balachandra, S; Dinh, TH; Kilmarx, PH; Mugurungi, O; Mushavi, A; Nyakura, J; Shambira, G; Shiraishi, RW; Tippett Barr, B; Tshimanga, M; Zinyowera, S | 1 |
| Kan, W; Leng, X; Liao, L; Liu, P; Ruan, Y; Shao, Y; Wang, J; Xing, H; Xu, W; Yan, J; You, Y; Zuo, Z | 1 |
| Arnett, DK; Bagchi, S; Chi, BH; Heimburger, DC; Kabagambe, EK; Kiage, JN; Koethe, JR; Nyirenda, CK; Wellons, MF | 1 |
| Charalambous, S; Churchyard, GJ; Grant, AD; Hoffmann, CJ; Lewis, JJ; Velen, K | 1 |
| Abbas, SQ; Abro, AG; Baig-Ansari, N; Kazi, MA; Mir, F; Qamar, FN; Rizvi, A; Zaidi, AK | 1 |
| Holla, P; Jameel, S; Munshi, SU; Panda, H; Rewari, BB | 1 |
| Imai, Y; Kawamoto, M; Kohara, N; Sekiya, H; Togo, M; Yoshimura, H | 1 |
| Bader, J; Glass, TR; Klimkait, T; Labhardt, ND; Lejone, TI; Puga, D; Ringera, I | 1 |
| Cai, W; Caughey, B; Chung, C; Dai, Z; Hu, F; Lan, Y; Li, L; Tang, X; Zhang, K | 1 |
| Belyhun, Y; Liebert, UG; Maier, M | 1 |
| Bacha, T; Olana, T; Tadesse, BT; Worku, W | 1 |
| Boulle, A; Cohen, K; Davies, MA; de Waal, R; Fortuin-de Smidt, M; Igumbor, EU; Maartens, G; Stinson, K; Technau, KG | 1 |
| Hamada, Y | 1 |
| Gray, GE; Saloojee, H | 1 |
| Caffrey, M; Cook, JL; Ghassemi, M; Konrad, M; Lavie, A; Monnerjahn, C; Novak, RM; Sekulic, N; Su, Y | 1 |
| Hamprecht, K; Schott, H; Schott, S; Schott, TC; Schwendener, RA | 1 |
| Adams, E; Baert, L; Hoogmartens, J; Pendela, M; Rosier, J; Van den Mooter, G; Van Gyseghem, E | 1 |
| Huisinga, W; von Kleist, M | 1 |
| Barr, EA; Davies, JK; Forster-Harwood, J; Kinzie, K; Levin, MJ; McFarland, EJ; Pappas, J; Paul, SM; Salbenblatt, CR; Soda, E; Vazquez, A; Weinberg, A | 1 |
| Ammann, AJ | 1 |
| Bruun, J; Clotet, B; Cozzi-Lepri, A; Eg Hansen, AB; Horban, A; Katlama, C; Lundgren, JD; Martinez-Picado, J; Monforte, Ad; Phillips, AN | 1 |
| Cihlar, T; Ray, AS | 1 |
| Amuron, B; Birungi, J; Bunnell, R; Coutinho, A; Foster, S; Grosskurth, H; Jaffar, S; Kyomuhangi, R; Levin, J; Mermin, J; Nabiryo, C; Namara, G; Ndembi, N; Opio, A; Tappero, JW | 1 |
| Davey, RT; Dewar, R; Follmann, DA; Herpin, B; Huang, CY; Kovacs, J; Lane, HC; Masur, H; Metcalf, JA; Polis, MA; Shah, A; Shen, J; Tavel, JA; Vasudevachari, MB | 1 |
| Brenner, B | 1 |
| Avihingsanon, A; Belloso, WH; Boesecke, C; Cooper, DA; Duncombe, C; Emery, S; Gazzard, B; Li, L; Molina, JM; Petoumenos, K; Puls, RL; Srasuebkul, P | 1 |
| Bachani, D; Chan, PL; Deshpande, A; Rajasekaran, S; Rewari, BB; Srikantiah, P | 1 |
| Dhlomo, S; Emery, S; Grandits, G; Khabo, P; Khanyile, T; Komati, S; Magongoa, D; Naidoo, LC; Neaton, JD; Polis, M; Qolohle, D; Ratsela, A | 1 |
| Biwolé-Sida, M; Bork, K; Coudray, M; Cournil, A; Delaporte, E; Essomba, CN; Kouanfack, C; Laurent, C; Tonfack, CA | 1 |
| Dugange, F; Harms, G; Jordan-Harder, B; Kirsten, I; Kunz, A; Sewangi, J; Theuring, S; Ziske, J | 1 |
| Achalapong, J; Beck, IA; Britto, P; Chotivanich, N; Cressey, TR; Frenkel, L; Jourdain, G; Maupin, R; Mirochnick, M; Ngo-Giang-Huong, N; Prommas, S; Puthanakit, T; Rasri, W; Roongpisuthipong, A; Shapiro, DE; Van Dyke, RB; Yuthavisuthi, P | 1 |
| Aurpibul, L; Capparelli, E; Chokephaibulkit, K; Cressey, TR; Eksaengsri, A; Hongsiriwon, S; Kabat, B; Limwongse, C; McIntosh, K; Muresan, P; Ngampiyaskul, C; Sirisanthana, V; Smith, ME; Toye, M; Wittawatmongkol, O; Yogev, R | 1 |
| Selwood, D | 1 |
| Hirase, C; Maeda, Y; Matsumura, I; Miyatake, J; Morita, Y; Sasakawa, A; Yamaguchi, T | 1 |
| Bonovas, S; Hatzakis, A; Nikolopoulos, G; Tsiodras, S | 1 |
| Kemapunmanus, M; Nittayananta, W; Sriplung, H; Talungchit, S; Yangngam, S | 1 |
| Armishaw, J; Cameron, PU; Chuah, J; Cooper, DA; Crowe, SM; Fairley, C; Gouillou, M; Hearps, A; Koelsch, KK; Leeansyah, E; Lewin, SR; Liu, JP; Pierce, AB; Smit, de V; Solomon, A; Spelman, T; Tennakoon, S; Velayudham, P | 1 |
| Adachi, M; Antonelli, G; Bambacioni, F; Focher, F; Riva, E; Sampath, J; Scagnolari, C; Schuetz, JD; Turriziani, O | 1 |
| Allen, TM; Kelleher, AD; Walker, BD; Zaunders, J | 1 |
| Antonelli, G; Bambacioni, F; Bellomi, F; Focher, F; Gentile, M; Scagnolari, C; Turriziani, O | 1 |
| Dierich, MP; El Attal, R; Falkensammer, B; Müllauer, B; Parson, W; Sarcletti, M; Stoiber, H | 1 |
| Aboulker, JP; Brun-Vézinet, F; Descamps, D; Flandre, P; Harel, M; Izopet, J; Joly, V; Lastère, S; Meiffrédy, V; Peytavin, G; Tamalet, C; Yéni, P; Zeng, AF | 1 |
| Bhatta, MP; Lewis, J; Nichols, SA; Vermund, SH | 1 |
| Paul, SM | 1 |
| Misra, K; Shukla, V; Watal, G | 1 |
| Balzarini, J; De Clercq, E; Kaminska, B; Orzeszko, A | 1 |
| Fisher, RL; Hernandez, JE; Hessenthaler, SM; Lonergan, JT; McComsey, GA; Sension, MG; Shalit, P; Ward, DJ; Williams, VC | 1 |
| Pendergrass, S; Qazi, S; Uckun, FM; Venkatachalam, TK | 1 |
| Cortina-Borja, M; Gray, L; Newell, ML | 1 |
| Brew, BJ; Pemberton, L; Ray, J | 1 |
| Fleming, RA; Furman, PA; Hes, J; Ishaq, KS; Iyer, N; Kucera, LS; Morris-Natschke, SL | 1 |
| Goldschmidt, V; Marquet, R | 1 |
| Bates, M; Chappey, C; Clair, MS; Fisher, R; Lanier, ER; Parkin, N; Ross, L; Tisdale, M | 1 |
| Aarnoutse, RE; Burger, DM; Verweij-van Wissen, CP | 1 |
| Antonelli, G; Antonelli, L; Butera, O; Gianotti, N; Girardi, E; Iaiani, G; Lazzarin, A; Mazzi, R; Parisi, SG; Turriziani, O | 1 |
| Engels, JW; Lazrek, HB; Rochdi, A; Taourirte, M; Vasseur, JJ | 1 |
| Boryski, J; Collu, G; Giliberti, G; Kraszewski, A; La Colla, P; Loddo, R; Sanna, G; Stawiński, J; Szymańska, A; Szymczak, M | 1 |
| Arribas, JR; Campo, RE; Cheng, AK; Chuck, S; DeJesus, E; Enejosa, J; Gallant, JE; Gazzard, B; Lu, B; McColl, D; Pozniak, AL; Toole, JJ | 1 |
| Jenny-Avital, ER | 1 |
| Brown, J; Heffernan-Vacca, S; Millery, M; Neu, N; Stimell, M | 1 |
| Andreotti, M; Ceffa, S; Cusato, M; Germano, P; Giuliano, M; Guidotti, G; Liotta, G; Loureiro, S; Mancini, MG; Marazzi, MC; Palombi, L; Pirillo, MF; Regazzi, M; Vella, S; Villani, P | 1 |
| Blauvelt, A; Hartley, O; Root, MJ; Sugaya, M | 1 |
| Dubé, MP; Grinspoon, SK; Komarow, L; Mulligan, K; Parker, RA; Robbins, GK; Roubenoff, R; Tebas, P | 1 |
| Calmy, A; Ditangco, R; Huffam, SE; Kaldor, JM; Saphonn, V; Srasuebkul, P; Zhou, J | 1 |
| Gulick, RM; Kuritzkes, DR; Ribaudo, HJ | 1 |
| Anderson, AM; Bartlett, JA; Kosinski, AS | 1 |
| Eron, JJ; Fiscus, SA; Foust, E; Kuruc, J; Leone, PA; McCoy, SI; Patterson, KB; Pilcher, CD; Williams, D; Wolf, L | 1 |
| Carlson, M; Goldenberg, DT; Gupta, A; Holland, GN; Kuppermann, BD; Novack, RD; Read, RW; Shiramizu, KM; Vaudaux, JD; Yu, F | 1 |
| Arizcorreta-Yarza, A; Collado, A; Fernández-Fuertes, E; Girón-González, JA; González-Serrano, M; López-Cortés, LF; Lozano, F; Macías, J; Merino, D; Mira, JA; Pineda, JA; Ríos-Villegas, MJ; Rivero, A; Torres-Tortoso, M; Valera-Bestard, B | 1 |
| Fromentin, E; Hernandez-Santiago, BI; Hurwitz, SJ; Obikhod, A; Schinazi, RF | 1 |
| Anglaret, X; Dabis, F; Dakoury-Dogbo, N; Diakite, N; Duvignac, J; Grundmann, C; Karcher, S; Kouadio, B; Marlink, R; Seyler, C; Toure, S; Traore, M | 1 |
| Fauci, AS | 1 |
| Duesberg, PH | 2 |
| Hirata, A; Itoh, W; Sugawara, I | 1 |
| Kurimura, T; Sakamoto, T; Tsuchie, H | 1 |
| Connell, EV; Hsu, MC; Richman, DD | 1 |
| Efron, B; Katzenstein, DA; Kozal, MJ; Kroodsma, K; Merigan, TC; Shafer, RW; Winters, MA | 1 |
| Kim, B; Loeb, LA | 2 |
| Cupler, EJ; Dalakas, MC; Danon, MJ; Hench, K; Jay, C; Ropka, M | 1 |
| Domanski, MJ; Egan, D; Follmann, DA; Pizzo, PA; Scalise, PP; Sloas, MM; Tucker, EE | 1 |
| Bryson, YJ; Deveikis, A; Frenkel, LM; Keller, M; Nielsen, K; Sim, MS; Stiehm, ER; Wei, LS | 1 |
| Clayton, DA; Eriksson, S; Xu, B | 1 |
| Gibb, DM; Newell, ML | 1 |
| Katzenstein, DA; Kozal, MJ; Merigan, TC; Shafer, RW; Winters, MA | 1 |
| Rennie, J | 1 |
| Andrieu, JM; Lu, W | 1 |
| Cohen, J | 4 |
| Richman, DD | 9 |
| Mayer, V; Schmidtmayerová, H | 1 |
| Hansen, JE; Mathiesen, LR; Nielsen, C; Nielsen, JO; Sørensen, AM | 1 |
| Ellis, MN; Felgner, J; Felgner, PL; Gardner, MF; Hostetler, KY; Ricci, J; Richman, DD; Selleseth, DW; Sridhar, CN | 1 |
| Boyer, E; Dong, H; Eastman, S; Holodniy, M; Kolberg, J; Margolis, D; Mole, L; Moss, J; Urdea, M | 1 |
| Medina, D; Strair, R | 1 |
| Anderson, LS; Cantu, AA; Drake, RR; Jones, R; Mao, F; Moyer, MP; Radominska, A; Rechtin, TM | 1 |
| Bindels, PJ; Coutinho, RA; Krol, A; Miedema, F; Roos, M; van den Hoek, JA; Veenstra, J | 1 |
| Dolezal, J; Hraba, T | 1 |
| Abdel-Rahman, RM; el-Baz, I; Fawzy, M; Seada, M | 2 |
| Cline, FA | 1 |
| Beall, G; Blick, G; Calabrese, LH; Conant, MA; Fisher, A; Galpin, JE; Goldstein, G; Grossman, HA; Hirsch, RL; Stampone, P | 1 |
| Fischl, MA; Lai, S; Meng, TC; Resnick, L; Richman, DD; Spector, SA | 1 |
| Bratt, G; Broliden, PA; Eriksson, L; Gilljam, G; Hinkula, J; Levén, B; Nordlund, S; Persson, C; Volvovitz, F; Wahren, B | 1 |
| D'Agostini, C; Favalli, C; Garaci, E; Grelli, S; Mastino, A; Perroni, L; Rocchi, G; Soscia, F | 1 |
| Frost, SD; McLean, AR | 1 |
| Borkowsky, W; Bourinbaiar, AS; Krasinski, K; Lee-Huang, S | 1 |
| Davison, FD; Kaczmarski, RS; Mufti, GJ; Pozniak, A; Sutherland, S | 1 |
| Lüthy, R | 1 |
| Blunt, JW; Boyd, MR; Bringmann, G; Buckheit, RW; Cardellina, JH; Cragg, GM; Hallock, YF; Manfredi, KP; McMahon, JB; Schäffer, M | 1 |
| Hostetler, KY; Kroneman, E; Kumar, R; Richman, DD; Sridhar, CN; van den Bosch, H; van Wijk, GM | 1 |
| Antonelli, G; Arici, C; Del Poggio, P; Dianzani, F; Gregis, GP; Ippolito, G; Riva, E | 1 |
| Aubertin, AM; Benzaria, S; Girardet, JL; Gosselin, G; Imbach, JL; Kirn, A; Maury, G; Pelicano, H; Perigaud, C | 1 |
| Mathé, G; Pontiggia, P | 1 |
| Aquaro, S; Balestra, E; Billich, A; Caliò, R; Peichl, P; Perno, CF; Rosenwirth, B; Villani, N | 1 |
| Cinque, P; Coen, M; Gallo, L; Gringeri, A; Landonio, G; Lazzarin, A; Meraviglia, P; Nosari, AM; Quirino, T; Ruggieri, A | 1 |
| Holodniy, M; Katzenstein, D; Kozal, M; Merigan, TC; Montoya, J; Ragni, M; Shafer, R; Winters, M | 1 |
| Maag, H; Nelson, JT; Prisbe, EJ; Steiner, JL | 1 |
| Bergé, P; Mildvan, D; Salgo, M; St Clair, M; Starrett, S | 1 |
| Baumgarten, R | 2 |
| Magnuson, T; Mourton, T; Toltzis, P | 1 |
| Hall, ET; Kuchta, RD; Melançon, P; Yan, JP | 1 |
| Amici, C; Beninati, S; Bergamini, A; Capozzi, M; Dini, L; Ghibelli, L; Milanese, G; Pesce, CD; Salanitro, A; Wagner, T | 1 |
| Armbrecht, C; Hengels, KJ; Jablonowski, H; Manegold, C; Mauss, S; Szelenyi, H | 1 |
| Cretton, EM; Hitchcock, MJ; Kaul, S; Kidd, LB; McClure, HM; Sommadossi, JP; Zhou, Z | 1 |
| Dawson, SC; Landsman, D; Lane, HC; Salzman, NP; Zhang, YM | 1 |
| Becker, NG; Motika, M | 1 |
| Andrews, JC; Hamilton, JD; Hartigan, PM; Simberkoff, MS; St Clair, MH; Vavro, CL | 1 |
| Anderson, C | 1 |
| Burrell, C; Kok, T; Li, P | 1 |
| Cremoni, L; D'Amico, P; Grassi, MG; Milazzo, F; Vaira, LL | 1 |
| Maddox, J | 2 |
| Baker, CJ; Bremer, JW; Dimitrov, DH; Doyle, M; Hollinger, FB; Kline, MW; Shearer, WT | 1 |
| Soeiro, R | 1 |
| Erickson, J; Ford, H; Gulnik, S; Hayashi, H; Kageyama, S; Mimoto, T; Murakawa, Y; Nomizu, M; Shirasaka, T; Takada, K | 1 |
| Groopman, JE; Kunzi, MS | 1 |
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| Hirsch, MS; Schooley, RT; Vogt, M | 1 |
| Harada, S; Kobayashi, N; Matsuda, A; Matsui, T; Nakashima, H; Ueda, T; Yamamoto, N | 1 |
| Chou, TC; Coleman, LA; Crumpacker, C; Furman, PA; Fyfe, JA; Hartshorn, KL; Hirsch, MS; Schooley, RT; Vogt, MW | 1 |
| Broder, S; Chabner, BA; DeVita, VT; Fauci, AS; Kovacs, JA | 1 |
| Hirsch, MS; Kaplan, JC | 2 |
| Kuno, S; Ueno, R | 2 |
| Bazin, H; Chattopadhyaya, J; Oberg, B; Remaud, G; Vrang, L | 1 |
| Beveridge, A; Herzyk, P; Neidle, S | 1 |
| Berenbaum, MC | 1 |
| Lin, TS; Prusoff, WH; Schinazi, RF | 1 |
| Gillis, JM; Hammer, SM | 1 |
| Brian, EL; Pagano, JS; Smith, MS | 1 |
| Furman, PA; Langlois, AJ; Miller, WH; Richards, CA; Spector, T; St Clair, MH; Weinhold, KJ | 1 |
| Kim, H; Parthasarathy, R | 1 |
| Broder, S; Kuno, S; Looney, DJ; Mitsuya, H; Ueno, R; Wong-Staal, F | 1 |
| Broder, S; Mitsuya, H; Webb, TR | 1 |
| Baba, M; Balzarini, J; De Clercq, E; Desmyter, J; Herdewijn, P; Pauwels, R; Schols, D; Snoeck, R | 1 |
| Chang, RS; He, YS; Smith, KM; Tabba, HD | 1 |
| Bazin, H; Chattopadhyaya, J; Datema, R; Ericson, AC; Gilljam, G; Hansen, J; Johansson, NG; Koshida, R; Moelling, K; Oberg, B | 1 |
| Henin, Y; Marechal, V; Montagnier, L; Schwartz, O | 1 |
| Busso, M; Hahn, EF; Mian, AM; Resnick, L | 1 |
| Jeffries, DJ | 2 |
| Darby, G; Larder, BA; Richman, DD | 1 |
| Boehme, RE; Chen, MS; Chernow, M; Chuang, RY; Marx, PA; Matthews, TR; McRoberts, MJ; Prisbe, EJ; Suttmann, RT; Wu, JC | 1 |
| Mitchell, WM; Montefiori, DC; Robinson, WE | 1 |
| Bitonti, F; De Simone, C; Delia, S; Falciano, M; Ferrazzi, M; Sorice, F; Tzantzoglou, S | 1 |
| Macy, LJ; McCaleb, G; Parker, WB; Secrist, JA; Shaddix, SC; Shannon, WM; Vince, R; White, EL | 1 |
| Itoh, W; Kimura, S; Mori, S; Shimada, K; Sugawara, I | 1 |
| Chu, CK; Eriksson, BF; Schinazi, RF | 1 |
| DeStephano, L; Fanning, M; Gelmon, K; Montaner, JS; O'Shaughnessy, M; Rooke, R; Soudeyns, H; Tremblay, M; Tsoukas, C; Yao, XJ | 1 |
| Colby, CB; Williams, GJ | 1 |
| Fischl, MA | 1 |
| Crowe, SM; Elbeik, T; Kirihara, J; McGrath, MS; Mills, J | 1 |
| Balzarini, J; De Clercq, E; Herdewijn, P | 1 |
| Fine, RL; Friedmann, RM; Gartner, S; Popovic, M; Skaleric, U; Szebeni, J; Wahl, LM; Wahl, SM; Weinstein, JN | 1 |
| Hotta, T; Inoue, T; Itoh, T; Nagai, Y; Ogura, M; Saitoh, H; Saneyoshi, M; Tomoda, Y; Tsushita, K; Yoshida, S | 1 |
| Hsia, K; Ripley, D; Spector, SA | 1 |
| Blair, PC; Fort, MM; Fuchs, BA; Germolec, DR; Luster, MI; McCay, JA; Munson, AE; Thompson, M; Tomaszewski, JE; White, KL | 1 |
| Balzarini, J; De Clercq, E; Johns, DG; Matthes, E; Meeus, P | 1 |
| Coutinho, RA; de Goede, RE; de Wolf, F; Eeftink-Schattenkerk, JK; Goudsmit, J; Huisman, JG; Lange, JM; Miedema, F; Schellekens, PT; Tersmette, M | 1 |
| Bhalla, K; Birkhofer, M; Cole, J; Graham, G; Grant, S; Li, GR; MacLaughlin, W; Volsky, DJ | 1 |
| Benenson, AS; Scutchfield, FD | 1 |
| Curless, RG | 1 |
| Collins, JM; Unadkat, JD | 1 |
| Wood, MJ | 1 |
| Broder, S; Mitsuya, H; Myers, CE; Yarchoan, R | 1 |
| Oksenhendler, E | 1 |
| Powderly, WG | 1 |
| Balachandran, R; Enrico, A; Gupta, P; Ho, M; Rinaldo, C | 1 |
| Morse, GD; Olson, J; Plank, C; Portmore, A; Reichman, RC; Taylor, C | 1 |
| Banks, S; Baseler, MW; Deyton, L; Falloon, J; Kirk, LE; Kovacs, JA; Lane, HC; Masur, H; Salzman, NP; Walker, RE | 1 |
| Abraham, NG; Ahmed, T; Brown, AC; Bucher, D; Distenfeld, A; Levere, RD; Lutton, JD; Niranjan, U | 1 |
| Agrawal, KC; Beckman, BS; Gogu, SR | 1 |
| Hitchcock, MJ; Ho, HT | 1 |
| Engle, K; Field, M; Gillespie, DH; Mitchell, WM; Montefiori, DC; Pellegrino, MG; Robinson, WE | 1 |
| Balzarini, J; De Clercq, E; Desmyter, J; Goubau, P; Herdewijn, P; Pauwels, R; Vandeputte, M; Vanderhaeghe, H | 1 |
| Carson, DA; Kornbluth, RS; Richman, DD | 1 |
| Baba, M; Balzarini, J; Broder, S; de Clercq, E; Herdewijn, P; Johns, DG; Pauwels, R | 1 |
| Biron, K; Lin, JC; Pagano, JS; Smith, MC; Zhang, ZX | 1 |
| Broder, S; Mitsuya, H | 1 |
| Broder, S; Yarchoan, R | 2 |
| Chou, TC; Coleman, LA; Durno, AG; Hirsch, MS; Kaplan, JC; Paradis, TJ; Schooley, RT; Vogt, MW | 1 |
| Cooney, DA; Gartner, S; Gerrard, TL; Hao, Z; Hartman, NR; Johns, DG; Perno, CF; Popovic, M; Wilson, YA; Yarchoan, R | 1 |
| Brownell, J; Daluge, S; Hua, M; Kiser, R; Lavelle, GC; Lee, FC; Qualls, J; Shannon, WM; Vince, R; Weislow, OS | 1 |
| Fitz-Gibbon, L; Tremblay, M; Wainberg, MA | 1 |
| Balfour, HH; Cantrill, HL; Erice, A; Henry, K; Jackson, B; Ussery, FM | 1 |
| Carter, WA; Mitchell, WM; Montefiori, DC; Robinson, WE; Strayer, DR | 1 |
| Allain, JP; Dubinsky, R; Fischl, MA; Klecker, RW; McAtee, N; McNeely, MC; Perno, CF; Thomas, RV; Wills, RJ; Yarchoan, R | 1 |
| Cload, P; Coutinho, RA; de Gans, J; de Wolf, F; Fiddian, AP; Goudsmit, J; Lange, JM; Schellekens, PT; van der Noordaa, J | 1 |
| Boucher, CA; Danner, SA; Goudsmit, J; Lange, JM; Reiss, P | 1 |
| Delord, B; Faivre, R; Fleury, HJ; Morere, G | 1 |
| Forster, S; Helbert, M; Jeffries, D; Kocsis, A; Peddle, B; Pinching, AJ; Robinson, D | 1 |
| Steel, M | 1 |
| de Gans, J; Portegies, P; Tiessens, G | 1 |
| Balzarini, J; De Clercq, E; Pauwels, R; Schols, D; Vanlangendonck, F | 1 |
| De Clercq, E | 1 |
| Marx, JL | 1 |
| Balzarini, J; de Clercq, E; Herdewijn, P; van Aerschot, A | 1 |
| Weber, J | 1 |
| Baba, M; De Clercq, E; Desmyter, J; Herdewijn, P; Pauwels, R; Vandeputte, M | 1 |
| Chen, MS; Kinney-Thomas, E; Lin, TS; Prusoff, WH; Schinazi, RF | 1 |
| Harada, S; Nakashima, H; Yamamoto, N | 1 |
| Hamamoto, Y; Matsuda, A; Matsui, T; Nakashima, H; Ueda, T; Yamamoto, N | 1 |
| Barry, DW; Furman, PA | 1 |
| Gallo, RC; Montagnier, L | 1 |
| Kobayashi, N; Matsuda, A; Nakashima, H; Tochikura, T; Ueda, T; Yamamoto, N | 1 |
| Kaneko, Y; Kobayashi, N; Nakashima, H; Tochikura, TS; Yamamoto, N | 1 |
| Ikuta, K; Imai, H; Kato, S; Suehiro, S; Ueda, S; Yamamoto, N | 2 |
| Despotes, JC; Emeson, EE; Falk, LA; Jackson, GG; Knigge, M; Mack, D; Paul, DA; Rubenis, M | 1 |
| Cload, P; Danner, SA; de Gans, J; de Wolf, F; Derix, MM; Eeftinck Schattenkerk, JK; Goudsmit, J; Lange, JM; Ongerboer de Visser, BW | 1 |
| Courouce, AM; Lefrere, JJ; Salmon, C | 1 |
| Dickmeiss, E; Permin, H | 1 |
| Ersbøll, J; Krebs, HJ; Mathiesen, L; Petersen, CS | 1 |
| Glaser, V | 1 |
| Langen, P; Lehmann, C; Matthes, E; Rosenthal, HA; Scholz, D | 1 |
| Balzarini, J; De Clercq, E; Kinjo, J; Lesiak, K; Torrence, PF | 1 |
| Gericke, D | 1 |
| Birch, C; Gust, I; Lucas, CR; Tachedjian, G | 1 |
| Carlisle, R; Schinazi, RF; Sommadossi, JP; Zhou, Z | 1 |
| Allain, JP; Boone, GS; Chaisson, RE; Feigal, D; Leuther, MD; Nusinoff-Lehrman, S; Volberding, P | 1 |
| Barnes, DM | 1 |
| Allain, JP; Chaisson, RE; Leuther, M; Volberding, PA | 1 |
| Blumberg, RS; Byington, R; Chou, TC; Hartshorn, KL; Hirsch, MS; Schooley, RT; Vogt, MW | 1 |
| Baba, M; De Clercq, E; Ito, M; Nakashima, H; Pauwels, R; Shigeta, S; Yamamoto, N | 1 |
| Jablon, L | 1 |
| Cohen, OJ; Lyerly, HK; Weinhold, KJ | 1 |
| Gallo, RC | 1 |
| Elwell, LP; Ferone, R; Freeman, GA; Fyfe, JA; Hill, JA; Knick, VB; Ray, PH; Richards, CA; Rideout, JL; Singer, SC | 1 |
Reviews
73 review(s) available for zidovudine and HIV
| Article | Year |
|---|---|
Polypharmacology in HIV inhibition: can a drug with simultaneous action against two relevant targets be an alternative to combination therapy?
Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Therapy, Combination; HIV; Humans; Microbial Sensitivity Tests; Molecular Structure; Polypharmacology | 2018 |
Prevention of the Vertical Transmission of HIV; A Recap of the Journey so Far.
Topics: Anti-HIV Agents; Child; Child, Preschool; Female; HIV; HIV Infections; Humans; Infant; Infectious Disease Transmission, Vertical; Pregnancy; Pregnancy Complications, Infectious; Zidovudine | 2023 |
Antivirals for prevention of hepatitis B virus mother-to-child transmission in human immunodeficiency virus positive pregnant women co-infected with hepatitis B virus.
Topics: Antiviral Agents; Coinfection; DNA, Viral; Emtricitabine; Female; Hepatitis B e Antigens; Hepatitis B virus; HIV; HIV Infections; HIV Seropositivity; Humans; Infant; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Pregnancy; Pregnant Women; Ritonavir; Tenofovir; Zidovudine | 2023 |
Recent progress in prodrug design strategies based on generally applicable modifications.
Topics: Amides; Animals; Anti-HIV Agents; Benzyl Compounds; Biological Availability; Carboxylic Acids; Drug Design; Esterification; HIV; HIV Infections; Humans; Prodrugs; Solubility; Zidovudine | 2017 |
Optimal versus suboptimal treatment for HIV-infected pregnant women and HIV-exposed infants in clinical research studies.
Topics: Antiretroviral Therapy, Highly Active; Clinical Trials as Topic; Drug Resistance, Viral; Female; HIV; HIV Infections; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Mutation; Nevirapine; Pregnancy; Pregnancy Complications, Infectious; Zidovudine | 2009 |
Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine.
Topics: Anti-HIV Agents; HIV; HIV Infections; HIV Reverse Transcriptase; Humans; Nucleosides; Nucleotides; Zidovudine | 2010 |
Antiretrovirals for HIV Exposure Prophylaxis.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Dideoxynucleosides; Emtricitabine; HIV; HIV Infections; Humans; Lamivudine; Occupational Exposure; Organophosphonates; Stavudine; Tenofovir; Zidovudine | 2012 |
STI and beyond: the prospects of boosting anti-HIV immune responses.
Topics: Acute Disease; Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Chronic Disease; HIV; HIV Infections; Humans; Zidovudine | 2002 |
Primer unblocking by HIV-1 reverse transcriptase and resistance to nucleoside RT inhibitors (NRTIs).
Topics: Adenosine Triphosphate; DNA Primers; Drug Resistance, Multiple, Viral; Foscarnet; HIV; HIV Reverse Transcriptase; Humans; Point Mutation; Reverse Transcriptase Inhibitors; Thymidine; Zidovudine | 2004 |
[Sulfated schizophyllan as a anti-HIV agent].
Topics: Animals; Antiviral Agents; Blood Coagulation; Carbohydrate Conformation; Cells, Cultured; Drug Synergism; Female; HIV; Humans; Lethal Dose 50; Mice; Molecular Weight; Reverse Transcriptase Inhibitors; Sizofiran; Structure-Activity Relationship; Zidovudine | 1993 |
A risk-benefit assessment of zidovudine in the prevention of perinatal HIV transmission.
Topics: Acquired Immunodeficiency Syndrome; Animals; Drug Resistance, Microbial; Female; Guidelines as Topic; HIV; HIV Infections; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Pregnancy; Pregnancy Complications, Infectious; Prenatal Exposure Delayed Effects; Randomized Controlled Trials as Topic; Risk Assessment; Zidovudine | 1995 |
HIV drug resistance.
Topics: Animals; Antiviral Agents; Drug Resistance, Microbial; HIV; Humans; Reverse Transcriptase Inhibitors; Zidovudine | 1993 |
Resistance, drug failure, and disease progression.
Topics: Antiviral Agents; Disease Progression; Drug Resistance, Microbial; Drug Therapy, Combination; HIV; HIV Infections; Humans; Nevirapine; Pyridines; Randomized Controlled Trials as Topic; Zalcitabine; Zidovudine | 1994 |
[Antiretroviral therapy. Current status and perspectives].
Topics: Antiviral Agents; CD4 Lymphocyte Count; Clinical Trials as Topic; Didanosine; Drug Therapy, Combination; HIV; HIV Infections; Humans; Stavudine; Zalcitabine; Zidovudine | 1994 |
[Therapy of HIV infection with nucleoside analogs].
Topics: Antiviral Agents; Didanosine; Drug Therapy, Combination; HIV; HIV Infections; Humans; Nucleosides; Zalcitabine; Zidovudine | 1993 |
Resistance of clinical isolates of human immunodeficiency virus to antiretroviral agents.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Drug Resistance, Microbial; HIV; HIV Infections; Humans; Zidovudine | 1993 |
Studies of zidovudine in combination with didanosine and zalcitabine.
Topics: Antiviral Agents; CD4 Lymphocyte Count; Clinical Trials as Topic; Didanosine; Disease Progression; Drug Resistance, Microbial; Drug Therapy, Combination; HIV; HIV Infections; Humans; Reverse Transcriptase Inhibitors; Safety; Zalcitabine; Zidovudine | 1995 |
ddC (zalcitabine).
Topics: Antiviral Agents; Drug Therapy, Combination; HIV; HIV Infections; Humans; Zalcitabine; Zidovudine | 1996 |
Human immunodeficiency virus replication in the presence of antiretroviral drugs: analogies to antineoplastic drug resistance.
Topics: Antineoplastic Agents; Antiviral Agents; Drug Resistance; HIV; Humans; Virus Replication; Zidovudine | 1996 |
[Monitoring anti-retroviral treatment].
Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Dideoxynucleosides; Drug Evaluation; Drug Resistance, Microbial; HIV; HIV Infections; Humans; Phenotype; RNA, Viral; Viremia; Zidovudine | 1996 |
Antiretroviral agents. Current usage.
Topics: Anti-HIV Agents; Drug Resistance, Microbial; Drug Therapy, Combination; Forecasting; HIV; HIV Infections; Humans; Research; Zidovudine | 1997 |
The surgeon's database for AIDS: a collective review.
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Databases, Factual; General Surgery; HIV; HIV Antibodies; HIV Infections; Humans; Infectious Disease Transmission, Patient-to-Professional; Infectious Disease Transmission, Professional-to-Patient; Seroepidemiologic Studies; Universal Precautions; Zidovudine | 1997 |
Antiretroviral therapy in human immunodeficiency virus-infected individuals.
Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Chemoprevention; Clinical Protocols; Decision Making; Drug Resistance, Microbial; Drug Therapy, Combination; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Infectious Disease Transmission, Vertical; Patient Care Planning; Reverse Transcriptase Inhibitors; RNA, Viral; Viral Load; Viremia; Virus Replication; Zidovudine | 1998 |
[Past, present and future of zidovudine, the first antiretroviral drug].
Topics: Anti-HIV Agents; Clinical Trials as Topic; Drug Resistance, Microbial; Drug Therapy, Combination; HIV; HIV Infections; Humans; Zidovudine | 1998 |
Resistance of HIV to antiretroviral agents. Basic concepts.
Topics: Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; CD4-Positive T-Lymphocytes; Drug Resistance, Microbial; HIV; Humans; Reverse Transcriptase Inhibitors; Thymidine Kinase; Zidovudine | 1998 |
Management of possible sexual, injecting-drug-use, or other nonoccupational exposure to HIV, including considerations related to antiretroviral therapy. Public Health Service statement. Centers for Disease Control and Prevention.
Topics: Animals; Anti-HIV Agents; Clinical Trials as Topic; Cost-Benefit Analysis; Drug Resistance, Microbial; Evaluation Studies as Topic; HIV; HIV Infections; Humans; Risk; Risk-Taking; Sexual Behavior; Substance Abuse, Intravenous; Zidovudine | 1998 |
Zidovudine: a review of pharmacoeconomic and quality-of-life considerations for its use in patients with human immunodeficiency virus.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Child, Preschool; Clinical Trials as Topic; Cost of Illness; Cost-Benefit Analysis; Drug Tolerance; Economics, Pharmaceutical; Evaluation Studies as Topic; Female; Formularies as Topic; Health Care Costs; HIV; HIV Infections; Humans; Infant, Newborn; Male; Models, Econometric; Occupational Exposure; Pregnancy; Quality of Life; Survival Rate; Zidovudine | 1993 |
[Rational therapy of HIV infections].
Topics: AIDS-Related Opportunistic Infections; Anti-HIV Agents; Diagnosis, Differential; Granulocyte Colony-Stimulating Factor; HIV; HIV Infections; Humans; Immune Tolerance; Mutation; Reverse Transcriptase Inhibitors; Zidovudine | 1999 |
Recurrence of the acute HIV syndrome after interruption of antiretroviral therapy in a patient with chronic HIV infection: A case report.
Topics: Acute Disease; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Chronic Disease; Disease Progression; Drug Therapy, Combination; Fever; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Male; Recurrence; Reverse Transcriptase Inhibitors; RNA, Viral; Syndrome; Viral Load; Zidovudine | 2000 |
HIV drug resistance and viral fitness.
Topics: Drug Resistance; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Reverse Transcriptase Inhibitors; Virus Replication; Zidovudine | 2000 |
Ethical issues in early detection of HIV infection to reduce vertical transmission.
Topics: Breast Feeding; Ethics; Female; Health Policy; HIV; HIV Seropositivity; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Informed Consent; Mandatory Testing; Pregnancy; Prenatal Care; Reverse Transcriptase Inhibitors; Time Factors; Zidovudine | 2000 |
A critical analysis of the pharmacology of AZT and its use in AIDS.
Topics: Anti-HIV Agents; HIV; HIV Core Protein p24; HIV Infections; Humans; In Vitro Techniques; Phosphorylation; Practice Guidelines as Topic; Reverse Transcriptase Inhibitors; Viral Load; Zidovudine | 1999 |
Emergence of mutant HIV reverse transcriptase conferring resistance to AZT.
Topics: Amino Acid Sequence; Antiviral Agents; Base Sequence; Drug Resistance, Microbial; Genotype; HeLa Cells; HIV; HIV Infections; Humans; Molecular Sequence Data; Mutation; Phenotype; RNA-Directed DNA Polymerase; Time Factors; Zidovudine | 1992 |
Anti-human immunodeficiency virus therapeutics: now and the future.
Topics: Acquired Immunodeficiency Syndrome; Didanosine; Dideoxynucleosides; HIV; HIV-1; Humans; Trichosanthin; Zalcitabine; Zidovudine | 1992 |
Reverse transcriptase of HIV as a target for anti-viral drugs.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Dideoxynucleosides; Drug Design; HIV; Humans; Reverse Transcriptase Inhibitors; Zidovudine | 1992 |
HIV drug resistance.
Topics: Amino Acid Sequence; Base Sequence; Dideoxynucleosides; DNA, Viral; Drug Resistance, Microbial; HIV; HIV Infections; Humans; Molecular Sequence Data; Zidovudine | 1992 |
Competition between zidovudine-sensitive and zidovudine-resistant strains of HIV.
Topics: CD4 Antigens; Drug Resistance, Microbial; HIV; HIV Infections; Host-Parasite Interactions; Humans; Models, Biological; Zidovudine | 1992 |
[Antiretroviral treatments and their therapeutical trials].
Topics: Antiviral Agents; Clinical Trials as Topic; HIV; HIV Infections; Humans; Zidovudine | 1992 |
Selection of zidovudine-resistant variants of human immunodeficiency virus by therapy.
Topics: Drug Resistance, Microbial; HIV; HIV Infections; Humans; Mutation; Zidovudine | 1992 |
[Treatments of human immunodeficiency virus infection. Current developments].
Topics: Acquired Immunodeficiency Syndrome; Didanosine; HIV; HIV Infections; Humans; Zalcitabine; Zidovudine | 1991 |
DNA polymerases versus HIV reverse transcriptase in AIDS therapy.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; DNA-Directed DNA Polymerase; HIV; Humans; RNA-Directed DNA Polymerase; Sensitivity and Specificity; Virus Replication; Zidovudine | 1990 |
Targeted therapy of human immunodeficiency virus-related disease.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Antiviral Agents; CD4 Antigens; Didanosine; Dideoxynucleosides; Dipyridamole; Drug Synergism; Gene Expression Regulation, Viral; Genes, nef; Genes, rev; Genes, tat; HIV; HIV Protease; Interferon Type I; Organophosphonates; RNA-Directed DNA Polymerase; Stavudine; Transcription, Genetic; Zalcitabine; Zidovudine | 1991 |
Anti-retroviral therapy of human immunodeficiency virus infection: current strategies and challenges for the future.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Didanosine; Drug Resistance; HIV; HIV Infections; Humans; Lymphoma, Non-Hodgkin; Retroviridae; Reverse Transcriptase Inhibitors; T-Lymphocytes, Helper-Inducer; Virus Replication; Zalcitabine; Zidovudine | 1991 |
Factors contributing to the inhibition of HIV reverse transcriptase by chain-terminating nucleotides in vitro and in vivo.
Topics: HIV; Nucleotides; Reverse Transcriptase Inhibitors; Templates, Genetic; Zidovudine | 1991 |
Derivation of new drugs for therapy of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Drug Design; HIV; HIV Envelope Protein gp120; HIV Protease Inhibitors; Humans; Reverse Transcriptase Inhibitors; Zidovudine | 1991 |
Preclinical evaluation of human hematolymphoid function in the SCID-hu mouse.
Topics: Acquired Immunodeficiency Syndrome; Animals; Bone Marrow Transplantation; Didanosine; Hematopoiesis; HIV; Humans; Liver Transplantation; Lymph Nodes; Mice; Mice, SCID; Models, Biological; Thymus Gland; Transplantation, Heterologous; Zidovudine | 1991 |
Therapy of AIDS and AIDS-related tumors.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; HIV; Hodgkin Disease; Humans; Lymphoma, Non-Hodgkin; Neoplasms; Sarcoma, Kaposi; Zidovudine | 1991 |
Antiviral therapy for human immunodeficiency virus infection in children.
Topics: Antiviral Agents; Child; HIV; HIV Infections; Humans; Virus Replication; Zidovudine | 1991 |
Early therapeutic intervention in HIV infection--stepping stones to success.
Topics: Drug Administration Schedule; Drug Resistance, Microbial; HIV; HIV Infections; Humans; Pneumonia, Pneumocystis; Survival Rate; Zidovudine | 1991 |
AZT resistance in isolates of HIV.
Topics: Acquired Immunodeficiency Syndrome; Drug Resistance, Microbial; HIV; HIV Infections; Humans; Zidovudine | 1991 |
Pharmacologic studies of nucleosides active against the human immunodeficiency virus.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Bone Marrow Diseases; HIV; Humans; Nucleosides; Zidovudine | 1990 |
Treatment of human immunodeficiency virus-infected infants and young children with dideoxynucleosides.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Child; Child, Preschool; Dideoxynucleosides; Drug Tolerance; HIV; HIV Infections; Humans; Infant; Zalcitabine; Zidovudine | 1990 |
Susceptibility to nucleoside analogues of zidovudine-resistant isolates of human immunodeficiency virus.
Topics: Antiviral Agents; Deoxyribonucleosides; Drug Resistance, Microbial; HIV; HIV Infections; Humans; Microbial Sensitivity Tests; Zidovudine | 1990 |
Antiviral therapy against HIV infection.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Dideoxynucleosides; HIV; HIV Infections; Humans; Zidovudine | 1990 |
Developmental therapeutics and the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Deoxyribonucleosides; HIV; Humans; Interferons; Interleukin-2; Opportunistic Infections; Pneumonia, Pneumocystis; Thymidine; Toxoplasmosis; Virus Replication; Zidovudine | 1987 |
Targets for antiviral therapy of human immunodeficiency virus infection.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Dideoxynucleosides; Drug Therapy, Combination; Genes, Regulator; HIV; Humans; Reverse Transcriptase Inhibitors; Virus Replication; Zalcitabine; Zidovudine | 1989 |
Clinical and basic advances in the antiretroviral therapy of human immunodeficiency virus infection.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Child; Dideoxynucleosides; Female; HIV; Humans; Pregnancy; Reverse Transcriptase Inhibitors; Virus Replication; Zidovudine | 1989 |
State of antiretroviral therapy with zidovudine.
Topics: Drug Interactions; HIV; HIV Infections; Humans; Opportunistic Infections; Zidovudine | 1989 |
AIDS update.
Topics: Acquired Immunodeficiency Syndrome; HIV; Humans; Viral Vaccines; Zidovudine | 1989 |
Congenital AIDS: review of neurologic problems.
Topics: Acquired Immunodeficiency Syndrome; HIV; Humans; Immune System; Infant, Newborn; Nervous System; Nervous System Diseases; Zidovudine | 1989 |
Clinical pharmacokinetics of zidovudine. An overview of current data.
Topics: Drug Interactions; Female; Half-Life; HIV; Humans; Maternal-Fetal Exchange; Pregnancy; Protein Binding; Semen; Zidovudine | 1989 |
Clinical pharmacology of 3'-azido-2',3'-dideoxythymidine (zidovudine) and related dideoxynucleosides.
Topics: Dideoxynucleosides; HIV; Humans; Zidovudine | 1989 |
Azidothymidine.
Topics: Acquired Immunodeficiency Syndrome; Anemia, Macrocytic; Clinical Trials as Topic; Drug Interactions; HIV; Humans; Neutropenia; Random Allocation; Zidovudine | 1989 |
[Causal therapy possibilities in HIV infections].
Topics: Antiviral Agents; HIV; HIV Infections; Humans; Virus Replication; Zidovudine | 1989 |
Zidovudine.
Topics: Acquired Immunodeficiency Syndrome; HIV; Humans; Virus Replication; Zidovudine | 1989 |
Progress in the development of antiviral therapy for HTLV-III-associated diseases.
Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Foscarnet; HIV; Humans; Phosphonoacetic Acid; Ribavirin; Rifabutin; Rifamycins; Suramin; Thymidine; Tungsten; Tungsten Compounds; Zidovudine | 1987 |
Perspectives for the chemotherapy of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Glycyrrhetinic Acid; Glycyrrhizic Acid; HIV; Humans; Polysaccharides; Suramin; Zidovudine | 1988 |
Spectrum of antiviral activity and mechanism of action of zidovudine. An overview.
Topics: Animals; Antiviral Agents; HIV; Humans; Retroviridae; Thymidine; Virus Replication; Zidovudine | 1988 |
AIDS therapies.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Drug Design; HIV; Humans; Immunotherapy; Zidovudine | 1988 |
AIDS in 1988.
Topics: Acquired Immunodeficiency Syndrome; Animals; Disease Outbreaks; HIV; HIV-1; HIV-2; Humans; Simian Immunodeficiency Virus; Viral Vaccines; Zidovudine | 1988 |
Treatment of human immunodeficiency virus infections.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Drug Therapy, Combination; HIV; Humans; Ribavirin; Thymidine; Zidovudine | 1987 |
Strategies for the future chemotherapy of human immunodeficiency virus (HIV).
Topics: Acquired Immunodeficiency Syndrome; Drug Evaluation; HIV; Humans; Thymidine; Zidovudine | 1987 |
Development of antiretroviral therapy for the acquired immunodeficiency syndrome and related disorders. A progress report.
Topics: Acquired Immunodeficiency Syndrome; HIV; Humans; Structure-Activity Relationship; Thymidine; Zidovudine | 1987 |
Trials
60 trial(s) available for zidovudine and HIV
| Article | Year |
|---|---|
Rates of virological failure in patients treated in a home-based versus a facility-based HIV-care model in Jinja, southeast Uganda: a cluster-randomised equivalence trial.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Community Health Services; Female; HIV; HIV Infections; Home Care Services; Humans; Lamivudine; Male; Nevirapine; Organophosphonates; Stavudine; Tenofovir; Uganda; Zidovudine | 2009 |
Interferon-alpha produces significant decreases in HIV load.
Topics: Adult; CD4-Positive T-Lymphocytes; Disease Progression; Drug Therapy, Combination; Female; Follow-Up Studies; HIV; HIV Infections; Humans; Immunophenotyping; Interferon-alpha; Male; Survival Analysis; Viral Load; Zidovudine | 2010 |
Efavirenz versus boosted atazanavir or zidovudine and abacavir in antiretroviral treatment-naive, HIV-infected subjects: week 48 data from the Altair study.
Topics: Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Dideoxynucleosides; Female; HIV; HIV Infections; Humans; Male; Middle Aged; Oligopeptides; Pyridines; RNA, Viral; Treatment Outcome; Viral Load; Zidovudine | 2010 |
A randomized factorial trial comparing 4 treatment regimens in treatment-naive HIV-infected persons with AIDS and/or a CD4 cell count <200 cells/μL in South Africa.
Topics: Acquired Immunodeficiency Syndrome; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Didanosine; Drug Therapy, Combination; Female; HIV; Humans; Lamivudine; Lopinavir; Male; Pyrimidinones; Ritonavir; RNA, Viral; South Africa; Stavudine; Treatment Outcome; Zidovudine | 2010 |
A comparison of 3 regimens to prevent nevirapine resistance mutations in HIV-infected pregnant women receiving a single intrapartum dose of nevirapine.
Topics: Adolescent; Adult; Anti-HIV Agents; Drug Administration Schedule; Drug Resistance, Viral; Female; HIV; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Middle Aged; Mutation; Nevirapine; Pregnancy; Pregnancy Complications, Infectious; Treatment Outcome; Viral Load; Zidovudine | 2012 |
Pharmacokinetics and safety of a new paediatric fixed-dose combination of zidovudine/lamivudine/nevirapine in HIV-infected children.
Topics: Anti-HIV Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biological Availability; Body Weight; Child; Child, Preschool; Cytochrome P-450 CYP2B6; Drug Administration Schedule; Drug Combinations; Drug Dosage Calculations; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; HIV; HIV Infections; Humans; Infant; Lamivudine; Male; Nevirapine; Oxidoreductases, N-Demethylating; Reverse Transcriptase Inhibitors; Tablets; Zidovudine | 2011 |
Effect of zidovudine resistance mutations on virologic response to treatment with zidovudine or stavudine, each in combination with lamivudine and indinavir.
Topics: Anti-HIV Agents; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Male; Mutation; Patient Compliance; RNA, Viral; Stavudine; Viral Load; Zidovudine | 2002 |
Improvement in lipoatrophy associated with highly active antiretroviral therapy in human immunodeficiency virus-infected patients switched from stavudine to abacavir or zidovudine: the results of the TARHEEL study.
Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Dideoxynucleosides; Female; HIV; HIV Infections; HIV-1; Humans; Lipodystrophy; Male; Middle Aged; RNA, Viral; Stavudine; Treatment Outcome; Viral Load; Zidovudine | 2004 |
Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV.
Topics: Adenine; Adolescent; Adult; Aged; Alkynes; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Deoxycytidine; Emtricitabine; Female; HIV; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Oxazines; Prospective Studies; RNA, Viral; Tenofovir; Zidovudine | 2006 |
Postexposure prophylaxis for HIV in children and adolescents after sexual assault: a prospective observational study in an urban medical center.
Topics: Adolescent; Adult; Anti-HIV Agents; Child; Drug Combinations; Female; HIV; HIV Infections; Humans; Lamivudine; Male; Middle Aged; New York City; Patient Compliance; Prospective Studies; Regression Analysis; Sex Offenses; Zidovudine | 2007 |
Triple antiretroviral prophylaxis administered during pregnancy and after delivery significantly reduces breast milk viral load: a study within the Drug Resource Enhancement Against AIDS and Malnutrition Program.
Topics: Adolescent; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; HIV; HIV Infections; Humans; Lamivudine; Milk, Human; Nevirapine; Pilot Projects; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, Third; RNA, Viral; Stavudine; Zidovudine | 2007 |
Long-term body fat outcomes in antiretroviral-naive participants randomized to nelfinavir or efavirenz or both plus dual nucleosides. Dual X-ray absorptiometry results from A5005s, a substudy of Adult Clinical Trials Group 384.
Topics: Absorptiometry, Photon; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Body Composition; Cyclopropanes; Didanosine; Drug Therapy, Combination; Female; HIV; HIV Infections; HIV Protease Inhibitors; HIV-Associated Lipodystrophy Syndrome; Humans; Lamivudine; Male; Middle Aged; Nelfinavir; Prospective Studies; Stavudine; Time Factors; Treatment Outcome; United States; Zidovudine | 2007 |
A comparison of three initial antiretroviral AIDS regimens.
Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Dideoxynucleosides; Double-Blind Method; Drug Therapy, Combination; Follow-Up Studies; HIV; HIV Infections; Humans; Lamivudine; Reverse Transcriptase Inhibitors; RNA, Viral; Zidovudine | 2007 |
Fixed duration interruptions are inferior to continuous treatment in African adults starting therapy with CD4 cell counts < 200 cells/microl.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Candidiasis; CD4 Lymphocyte Count; Disease Progression; Drug Administration Schedule; Esophageal Diseases; Female; HIV; Humans; Male; Middle Aged; Treatment Outcome; Uganda; Zidovudine; Zimbabwe | 2008 |
Early features of zidovudine-associated myopathy: histopathological findings and clinical correlations.
Topics: Adult; Biopsy; Electromyography; Electrophysiology; HIV; Humans; Middle Aged; Muscle Fatigue; Muscular Diseases; Zidovudine | 1995 |
Resistance, drug failure, and disease progression.
Topics: Antiviral Agents; Disease Progression; Drug Resistance, Microbial; Drug Therapy, Combination; HIV; HIV Infections; Humans; Nevirapine; Pyridines; Randomized Controlled Trials as Topic; Zalcitabine; Zidovudine | 1994 |
Safety and efficacy of thymopentin in zidovudine (AZT)-treated asymptomatic HIV-infected subjects with 200-500 CD4 cells/mm3: a double-blind placebo-controlled trial.
Topics: Adult; CD4 Lymphocyte Count; Disease Progression; Double-Blind Method; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Follow-Up Studies; HIV; HIV Core Protein p24; HIV Infections; Humans; Injections, Subcutaneous; Male; Middle Aged; Patient Compliance; Pentamidine; Pneumonia, Pneumocystis; Prognosis; Proportional Hazards Models; Thymopentin; Trimethoprim, Sulfamethoxazole Drug Combination; Zidovudine | 1995 |
Resistance to AZT and ddC during long-term combination therapy in patients with advanced infection with human immunodeficiency virus.
Topics: CD4-Positive T-Lymphocytes; Drug Resistance, Microbial; Drug Therapy, Combination; HeLa Cells; HIV; HIV Infections; Humans; Leukocyte Count; Time Factors; Zalcitabine; Zidovudine | 1994 |
Improved cell-mediated immune responses in HIV-1-infected asymptomatic individuals after immunization with envelope glycoprotein gp160.
Topics: Adult; CD4-Positive T-Lymphocytes; Female; Follow-Up Studies; Gene Products, env; HIV; HIV Core Protein p24; HIV Envelope Protein gp120; HIV Envelope Protein gp160; HIV Seropositivity; Humans; Immunity, Cellular; Immunization; Immunization, Secondary; Leukocyte Count; Lymphocyte Activation; Male; Middle Aged; Peptide Fragments; Protein Precursors; Recombinant Proteins; Zidovudine | 1994 |
Combination treatment with zidovudine, thymosin alpha 1 and interferon-alpha in human immunodeficiency virus infection.
Topics: Adult; CD4-Positive T-Lymphocytes; Combined Modality Therapy; Cytotoxicity, Immunologic; Drug Synergism; Female; HIV; HIV Infections; Humans; Immunologic Factors; Interferon-alpha; Leukocyte Count; Male; Risk Factors; Thymalfasin; Thymosin; Virus Replication; Zidovudine | 1994 |
Zidovudine resistance, syncytium-inducing phenotype, and HIV disease progression in a case-control study. The VA Cooperative Study Group.
Topics: Acquired Immunodeficiency Syndrome; Adult; Case-Control Studies; Drug Resistance, Microbial; Follow-Up Studies; Giant Cells; HIV; HIV Infections; Humans; Middle Aged; Phenotype; Retrospective Studies; Zidovudine | 1993 |
Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine. AIDS Clinical Trials Group.
Topics: Adult; CD4 Lymphocyte Count; Double-Blind Method; Drug Therapy, Combination; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Isoquinolines; Male; Quinolines; Reverse Transcriptase Inhibitors; RNA, Viral; Saquinavir; Treatment Outcome; Zalcitabine; Zidovudine | 1996 |
Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes.
Topics: Adult; Antiviral Agents; Base Sequence; Biomarkers; CD4 Lymphocyte Count; DNA Primers; Female; HIV; HIV Infections; HIV Reverse Transcriptase; Humans; In Situ Hybridization; Lymph Nodes; Male; Molecular Sequence Data; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Time Factors; Virus Replication; Zidovudine | 1996 |
Lamivudine plus zidovudine compared with zalcitabine plus zidovudine in patients with HIV infection. A randomized, double-blind, placebo-controlled trial. North American HIV Working Party.
Topics: Adult; Antiviral Agents; beta 2-Microglobulin; Biopterins; CD4 Lymphocyte Count; Double-Blind Method; Drug Therapy, Combination; Female; HIV; HIV Core Protein p24; HIV Infections; Humans; Lamivudine; Male; Neopterin; Polymerase Chain Reaction; RNA, Viral; Severity of Illness Index; Time Factors; Treatment Outcome; Zalcitabine; Zidovudine | 1996 |
The relation of virologic and immunologic markers to clinical outcomes after nucleoside therapy in HIV-infected adults with 200 to 500 CD4 cells per cubic millimeter. AIDS Clinical Trials Group Study 175 Virology Study Team.
Topics: Adult; Antiviral Agents; CD4 Lymphocyte Count; Didanosine; Disease Progression; Drug Therapy, Combination; Female; HIV; HIV Infections; Humans; Male; Middle Aged; Multivariate Analysis; Phenotype; Proportional Hazards Models; RNA, Viral; Treatment Outcome; Virus Replication; Zidovudine | 1996 |
Interleukin-2 in combination with zidovudine and didanosine is able to maintain high levels of CD4 cells and undetectable HIV viraemia.
Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Didanosine; Drug Therapy, Combination; Female; HIV; HIV Infections; Humans; Interleukin-2; Leukocyte Common Antigens; Male; Pilot Projects; RNA, Viral; Viremia; Zidovudine | 1998 |
Pilot study of zidovudine-lamivudine combination therapy in vertically HIV-infected antiretroviral-naive children.
Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Child; Child, Preschool; Drug Therapy, Combination; Female; HIV; HIV Infections; Humans; Infant; Infectious Disease Transmission, Vertical; Lamivudine; Male; Pilot Projects; RNA, Viral; Viral Load; Zidovudine | 1998 |
[Prophylaxis after occupational exposure to human immunodeficiency virus (HIV)].
Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-HIV Agents; Female; Health Knowledge, Attitudes, Practice; Health Personnel; HIV; HIV Seropositivity; Humans; Male; Middle Aged; Needlestick Injuries; Occupational Diseases; Occupational Exposure; Risk Assessment; Zidovudine | 1997 |
A phase I/II study of the protease inhibitor indinavir in children with HIV infection.
Topics: Adolescent; Adult; Biological Availability; Capsules; CD4 Lymphocyte Count; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Infant; Lamivudine; Male; Suspensions; Viral Load; Virus Replication; Zidovudine | 1998 |
Correlation of response to treatment and HIV genotypic changes during phase III trials with saquinavir and reverse transcriptase inhibitor combination therapy.
Topics: Amino Acid Sequence; DNA, Viral; Drug Resistance, Microbial; Drug Therapy, Combination; Genotype; HIV; HIV Infections; HIV Protease; HIV Protease Inhibitors; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation; Phenotype; Proviruses; Reverse Transcriptase Inhibitors; RNA, Viral; Saquinavir; Treatment Outcome; Zalcitabine; Zidovudine | 1998 |
An open randomized controlled trial of zidovudine plus lamivudine versus stavudine plus lamivudine.
Topics: Adult; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes; Drug Therapy, Combination; HIV; HIV Infections; HIV Protease Inhibitors; Homosexuality, Male; Humans; Indinavir; Lamivudine; Male; Middle Aged; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; RNA, Viral; Stavudine; Treatment Outcome; Viral Load; Zidovudine | 1998 |
A randomized, controlled, double-blind study comparing the survival benefit of four different reverse transcriptase inhibitor therapies (three-drug, two-drug, and alternating drug) for the treatment of advanced AIDS. AIDS Clinical Trial Group 193A Study T
Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Didanosine; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV; Humans; Male; Nevirapine; Placebos; Reverse Transcriptase Inhibitors; RNA, Viral; Survival Rate; Time Factors; Zalcitabine; Zidovudine | 1998 |
Intermittent selection pressure with zidovudine plus zalcitabine treatment reduces the emergence in vivo of zidovudine resistance HIV mutations.
Topics: Adult; Amino Acid Substitution; Anti-HIV Agents; CD4 Lymphocyte Count; DNA Mutational Analysis; Drug Administration Schedule; Drug Resistance, Microbial; Drug Therapy, Combination; Female; HIV; HIV Infections; HIV Reverse Transcriptase; Humans; Male; Mutation; RNA, Viral; Zalcitabine; Zidovudine | 1999 |
Therapeutic vaccination with p24-VLP and zidovudine augments HIV-specific cytotoxic T lymphocyte activity in asymptomatic HIV-infected individuals.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS Vaccines; Anti-HIV Agents; CD4-CD8 Ratio; Cohort Studies; Female; HIV; HIV Core Protein p24; Humans; Male; Middle Aged; Polymerase Chain Reaction; RNA, Viral; T-Lymphocytes, Cytotoxic; Viral Load; Zidovudine | 1999 |
Mechanisms of virologic failure in previously untreated HIV-infected patients from a trial of induction-maintenance therapy. Trilège (Agence Nationale de Recherches sur le SIDA 072) Study Team).
Topics: Anti-HIV Agents; Case-Control Studies; Drug Resistance, Microbial; Drug Therapy, Combination; Genotype; HIV; HIV Infections; Humans; Indinavir; Lamivudine; Patient Compliance; Treatment Failure; Viral Load; Zidovudine | 2000 |
3-year suppression of HIV viremia with indinavir, zidovudine, and lamivudine.
Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Genotype; HIV; HIV Infections; Humans; Indinavir; Kidney Calculi; Lamivudine; Male; Middle Aged; RNA, Viral; Viral Load; Viremia; Zidovudine | 2000 |
Disease progression and early viral dynamics in human immunodeficiency virus-infected children exposed to zidovudine during prenatal and perinatal periods.
Topics: Anti-HIV Agents; Child; Child, Preschool; Cohort Studies; Disease Progression; HIV; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Multivariate Analysis; Outcome Assessment, Health Care; Perinatal Care; Prenatal Care; RNA, Viral; Zidovudine | 2000 |
In vivo antagonism with zidovudine plus stavudine combination therapy.
Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Therapy, Combination; Female; HIV; HIV Infections; Humans; Male; RNA, Viral; Stavudine; Zidovudine | 2000 |
Zidovudine triphosphate and lamivudine triphosphate concentration-response relationships in HIV-infected persons.
Topics: Adolescent; Adult; Aged; Anti-HIV Agents; CD4 Lymphocyte Count; Cytidine Triphosphate; Dideoxynucleotides; Dose-Response Relationship, Drug; Drug Therapy, Combination; HIV; HIV Infections; Humans; Lamivudine; Leukocytes, Mononuclear; Middle Aged; Prospective Studies; Regression Analysis; Reverse Transcriptase Inhibitors; RNA, Viral; Thymine Nucleotides; Zidovudine | 2000 |
Abacavir-lamivudine-zidovudine vs indinavir-lamivudine-zidovudine in antiretroviral-naive HIV-infected adults: A randomized equivalence trial.
Topics: Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Dideoxynucleosides; Double-Blind Method; Drug Resistance, Microbial; Female; Genotype; HIV; HIV Infections; HIV Protease Inhibitors; HIV Reverse Transcriptase; Humans; Indinavir; Lamivudine; Male; Middle Aged; Mutation; Reverse Transcriptase Inhibitors; Survival Analysis; Therapeutic Equivalency; Viral Load; Zidovudine | 2001 |
Long-term virologic and immunologic responses in human immunodeficiency virus type 1-infected children treated with indinavir, zidovudine, and lamivudine.
Topics: Adolescent; Anti-HIV Agents; CD4 Antigens; CD4 Lymphocyte Count; Child; Child, Preschool; Drug Therapy, Combination; Female; Follow-Up Studies; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Leukocyte Common Antigens; Male; Protein Tyrosine Phosphatase, Non-Receptor Type 1; RNA, Viral; Viral Load; Zidovudine | 2001 |
Combination shows reduction in viral levels.
Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Drug Therapy, Combination; HIV; HIV Protease Inhibitors; HIV Seropositivity; Humans; Indinavir; Lamivudine; Time Factors; Zidovudine | 1996 |
Drug combination shows benefits for AIDS patients with history of taking AZT.
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; CD4 Lymphocyte Count; Double-Blind Method; Drug Therapy, Combination; Follow-Up Studies; HIV; Humans; Lamivudine; Reverse Transcriptase Inhibitors; RNA, Viral; Time Factors; Zidovudine | 1996 |
Phase II/III Trials of Viracept start.
Topics: Anti-HIV Agents; Blood; CD4 Lymphocyte Count; Drug Therapy, Combination; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Isoquinolines; Lamivudine; Nelfinavir; Pilot Projects; Reverse Transcriptase Inhibitors; Stavudine; Sulfonic Acids; Time Factors; Zidovudine | 1996 |
Reappraising d4T.
Topics: CD4 Lymphocyte Count; HIV; HIV Infections; Humans; Randomized Controlled Trials as Topic; Stavudine; Zidovudine | 1995 |
Major study shows AZT monotherapy inferior.
Topics: CD4 Lymphocyte Count; Clinical Trials as Topic; Didanosine; Drug Therapy, Combination; HIV; HIV Infections; Humans; Randomized Controlled Trials as Topic; Zalcitabine; Zidovudine | 1995 |
[Antiretroviral treatments and their therapeutical trials].
Topics: Antiviral Agents; Clinical Trials as Topic; HIV; HIV Infections; Humans; Zidovudine | 1992 |
Peripheral nerve function in persons with asymptomatic or minimally symptomatic HIV disease: absence of zidovudine neurotoxicity.
Topics: Acquired Immunodeficiency Syndrome; Adult; HIV; Humans; Male; Neurons, Afferent; Peripheral Nervous System Diseases; Placebos; Zidovudine | 1991 |
Augmentation of cellular immune function during the early phase of zidovudine treatment of AIDS patients.
Topics: Acquired Immunodeficiency Syndrome; Adult; CD4-Positive T-Lymphocytes; Cohort Studies; Cytomegalovirus; Female; Follow-Up Studies; Gene Products, gag; HIV; HIV Antigens; HIV Core Protein p24; Humans; Immunity, Cellular; Interferon-gamma; Killer Cells, Natural; Leukocyte Count; Lymphocyte Activation; Male; Middle Aged; Phytohemagglutinins; Simplexvirus; T-Lymphocytes; Viral Core Proteins; Zidovudine | 1991 |
Mismatched double-stranded RNA, Ampligen (poly(I): poly(C12U), demonstrates antiviral and immunostimulatory activities in HIV disease.
Topics: Adjuvants, Immunologic; Antiviral Agents; CD4-Positive T-Lymphocytes; HIV; HIV Infections; Humans; Leukocyte Count; Poly I-C; Poly U; RNA, Double-Stranded; Zidovudine | 1991 |
Drug level monitoring in a double-blind multicenter trial: false-positive zidovudine measurements in AIDS clinical trials group protocol 019.
Topics: Acquired Immunodeficiency Syndrome; Chromatography, High Pressure Liquid; False Positive Reactions; Fluorescence Polarization Immunoassay; Fluorescent Antibody Technique; HIV; Hot Temperature; Humans; Quality Control; Radioimmunoassay; Spectrophotometry, Ultraviolet; Zidovudine | 1991 |
Dideoxycytidine (ddC): a potent antiretroviral agent for human immunodeficiency virus infection. An introduction.
Topics: Clinical Trials as Topic; Drug Therapy, Combination; HIV; HIV Infections; Humans; Zalcitabine; Zidovudine | 1990 |
[Chemotherapy and immunoprophylaxis of HIV infection].
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Foscarnet; HIV; Humans; Phosphonoacetic Acid; Reverse Transcriptase Inhibitors; Ribavirin; Suramin; Thymidine; Viral Vaccines; Virus Replication; Zidovudine | 1986 |
The use of zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Clinical Trials as Topic; HIV; Humans; Zidovudine | 1989 |
Azidothymidine.
Topics: Acquired Immunodeficiency Syndrome; Anemia, Macrocytic; Clinical Trials as Topic; Drug Interactions; HIV; Humans; Neutropenia; Random Allocation; Zidovudine | 1989 |
Zidovudine in patients with human immunodeficiency virus (HIV) infection and Kaposi sarcoma. A phase II randomized, placebo-controlled trial.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anemia; Double-Blind Method; Drug Evaluation; Granulocytes; HIV; Humans; Leukocyte Count; Male; Middle Aged; Prospective Studies; Random Allocation; Sarcoma, Kaposi; Zidovudine | 1989 |
Effect of zidovudine on serum human immunodeficiency virus antigen levels in symptom-free subjects.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Antigens, Viral; Antiviral Agents; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; HIV; Homosexuality; Humans; Male; Random Allocation; Thymidine; Zidovudine | 1988 |
Human immunodeficiency virus (HIV) antigenemia (p24) in the acquired immunodeficiency syndrome (AIDS) and the effect of treatment with zidovudine (AZT).
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antigens, Viral; Antiviral Agents; Clinical Trials as Topic; Double-Blind Method; HIV; HIV Antigens; HIV Core Protein p24; Humans; Lymphocytes; Retroviridae Proteins; Thymidine; Zidovudine | 1988 |
Effect of zidovudine on serum human immunodeficiency virus core antigen levels. Results from a placebo-controlled trial.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Double-Blind Method; Drug Evaluation; HIV; HIV Antigens; Humans; Leukocyte Count; Random Allocation; T-Lymphocytes; Zidovudine | 1988 |
"On the shelf" AIDS drug in clinical trial.
Topics: Acquired Immunodeficiency Syndrome; Clinical Trials as Topic; Fusidic Acid; HIV; Humans; Thymidine; Virus Replication; Zidovudine | 1987 |
Other Studies
464 other study(ies) available for zidovudine and HIV
| Article | Year |
|---|---|
3',3'-Difluoro-3'-deoxythymidine: comparison of anti-HIV activity to 3'-fluoro-3'-deoxythymidine.
Topics: Antiviral Agents; Dideoxynucleosides; HIV; Molecular Conformation; Structure-Activity Relationship | 1992 |
Synthesis and anti-HIV activity of 4'-azido- and 4'-methoxynucleosides.
Topics: Antiviral Agents; Cell Line; HIV; Nucleosides; Structure-Activity Relationship | 1992 |
Synthesis and anti-HIV activity of 4'-thio-2',3'-dideoxynucleosides.
Topics: Antiviral Agents; Dideoxynucleosides; HIV | 1992 |
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin- 2(1H)-one (TIBO) derivatives.
Topics: Antiviral Agents; Benzodiazepinones; Chemical Phenomena; Chemistry; HIV; Structure-Activity Relationship; Virus Replication | 1991 |
Escherichia coli mediated biosynthesis and in vitro anti-HIV activity of lipophilic 6-halo-2',3'-dideoxypurine nucleosides.
Topics: Adenosine Deaminase; Cells, Cultured; Chemical Phenomena; Chemistry; Dideoxynucleosides; Escherichia coli; HIV; Kinetics; Prodrugs; Structure-Activity Relationship | 1991 |
Potential anti-AIDS drugs. Lipophilic, adenosine deaminase-activated prodrugs.
Topics: Adenosine Deaminase; Antiviral Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Dideoxynucleosides; HIV; Kinetics; Prodrugs; Structure-Activity Relationship | 1991 |
Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders.
Topics: AIDS Dementia Complex; Animals; Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Chemistry, Physical; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Kinetics; Molecular Structure; Phosphorylation; Pyrimidine Nucleosides; Rabbits; Stavudine; T-Lymphocytes; Thymidine Kinase; Thymus Gland; Zidovudine | 1990 |
Synthesis and anti-HIV activity of several 2'-fluoro-containing pyrimidine nucleosides.
Topics: Antineoplastic Agents; Antiviral Agents; Cell Line; Cell Survival; Chemical Phenomena; Chemistry; Fluorine; Gene Products, gag; HIV; HIV Antigens; HIV Core Protein p24; Humans; Macrophages; Molecular Structure; Monocytes; Pyrimidine Nucleosides; T-Lymphocytes; Tumor Cells, Cultured; Viral Core Proteins; Zalcitabine; Zidovudine | 1990 |
Synthesis and antiviral activity of some acyclic and C-acyclic pyrrolo[2,3-d]pyrimidine nucleoside analogues.
Topics: Antiviral Agents; Chemical Phenomena; Chemistry; HIV; Magnetic Resonance Spectroscopy; Molecular Structure; Pyrimidine Nucleosides; Pyrroles; Simplexvirus | 1990 |
Synthesis and anti-HIV activity of carbocyclic 2',3'-didehydro-2',3'-dideoxy 2,6-disubstituted purine nucleosides.
Topics: Animals; Antiviral Agents; Chemical Phenomena; Chemistry; Cytopathogenic Effect, Viral; Dideoxyadenosine; Dideoxynucleosides; HIV; Leukemia P388; Molecular Structure; Purine Nucleosides; Structure-Activity Relationship; Tumor Cells, Cultured; Virus Replication; Zidovudine | 1990 |
Synthesis, antiretrovirus effects, and phosphorylation kinetics of 3'-isocyano-3'-deoxythymidine and 3'-isocyano-2',3'-dideoxyuridine.
Topics: Antimetabolites; Antiviral Agents; Cell Survival; Chemical Phenomena; Chemistry; Dideoxynucleosides; HIV; Kinetics; Phosphorylation; Thymidine; Thymidine Kinase; Virus Replication | 1990 |
Cyclobut-A and cyclobut-G: broad-spectrum antiviral agents with potential utility for the therapy of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Animals; Antiviral Agents; Guanine; Herpesviridae; HIV; Humans; Mice; Microbial Sensitivity Tests | 1990 |
Synthesis and biological evaluation of prodrugs of zidovudine.
Topics: Animals; Antiviral Agents; Chemical Phenomena; Chemistry; HIV; Humans; Microsomes, Liver; Prodrugs; Rats; Structure-Activity Relationship; Virus Replication; Zidovudine | 1990 |
Synthesis and anti-HIV evaluation of 2',3'-dideoxyribo-5-chloropyrimidine analogues: reduced toxicity of 5-chlorinated 2',3'-dideoxynucleosides.
Topics: Antiviral Agents; Cell Line; Dideoxynucleosides; HIV; Humans; Molecular Conformation; X-Ray Diffraction | 1990 |
Brain targeting of anti-HIV nucleosides: synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3'-azido-2',3'-dideoxyuridine and 3'-azido-3'-deoxythymidine.
Topics: Animals; Antiviral Agents; Brain; Chemical Phenomena; Chemistry; Dihydropyridines; Half-Life; HIV; Humans; Mice; Molecular Structure; Prodrugs; Zidovudine | 1990 |
1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent.
Topics: Antiviral Agents; Bone Marrow; Dideoxynucleosides; HIV; Stavudine; Thymidine; Zidovudine | 1989 |
Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides.
Topics: Animals; Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; HIV; Magnetic Resonance Spectroscopy; Purine Nucleosides; Pyrimidine Nucleosides; Structure-Activity Relationship; Virus Replication; Zidovudine | 1988 |
Synthesis and antiviral activity of various 3'-azido analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1, HTLV-III/LAV).
Topics: Antiviral Agents; HIV; Humans; Pyrimidine Nucleosides; Structure-Activity Relationship | 1988 |
3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.
Topics: Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Cytopathogenic Effect, Viral; Deoxyribonucleosides; HIV; Humans; Structure-Activity Relationship; T-Lymphocytes; Virus Replication | 1987 |
Synthesis and anti-HIV activity of various 2'- and 3'-substituted 2',3'-dideoxyadenosines: a structure-activity analysis.
Topics: Antiviral Agents; Deoxyadenosines; Dideoxyadenosine; HIV; Structure-Activity Relationship | 1987 |
Synthesis and antiviral activity of various 3'-azido, 3'-amino, 2',3'-unsaturated, and 2',3'-dideoxy analogues of pyrimidine deoxyribonucleosides against retroviruses.
Topics: Antiviral Agents; Cell Line; HIV; Indicators and Reagents; Magnetic Resonance Spectroscopy; Moloney murine leukemia virus; Pyrimidine Nucleosides; Spectrophotometry; Structure-Activity Relationship | 1987 |
Synthesis and antiviral activity of 8-aza analogs of chiral [2-(phosphonomethoxy) propyl]guanines.
Topics: Antiviral Agents; Aza Compounds; Cell Line; Guanine; HIV; Humans; Stereoisomerism | 1995 |
Synthesis and antiproliferative and antiviral activity of 2'-deoxy-2'-fluoroarabinofuranosyl analogs of the nucleoside antibiotics toyocamycin and sangivamycin.
Topics: Antibiotics, Antineoplastic; Antiviral Agents; Arabinonucleosides; Cytomegalovirus; Herpesvirus 1, Human; HIV; Humans; KB Cells; Pyrimidine Nucleosides; Toyocamycin | 1995 |
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Topics: Animals; Antiviral Agents; Base Sequence; Biological Availability; HIV; HIV Reverse Transcriptase; HIV-1; Indoles; Macaca mulatta; Molecular Sequence Data; Molecular Structure; Reverse Transcriptase Inhibitors; Sulfoxides | 1993 |
Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (+/-)-calanolide A and its enantiomers.
Topics: Antiviral Agents; Chromatography, High Pressure Liquid; Coumarins; HIV; HIV Reverse Transcriptase; Nucleic Acid Synthesis Inhibitors; Pyranocoumarins; RNA-Directed DNA Polymerase; Stereoisomerism | 1996 |
Antitumor agents. 166. Synthesis and biological evaluation of 5,6,7,8-substituted-2-phenylthiochromen-4-ones.
Topics: Antineoplastic Agents; Antiviral Agents; Cell Line; Chromans; HIV; Humans; Magnetic Resonance Spectroscopy; Structure-Activity Relationship; Tumor Cells, Cultured | 1996 |
Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.
Topics: 3T3 Cells; Animals; Antiviral Agents; HIV; Mice; Phosphates; Stavudine; Structure-Activity Relationship | 1996 |
Bioactive kaurane diterpenoids from Annona glabra.
Topics: Anti-HIV Agents; Carbohydrate Sequence; Diterpenes; HIV; Humans; Lymphocytes; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Sequence Data; Plants, Medicinal; Reverse Transcriptase Inhibitors; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 1998 |
Rational design of a new series of pronucleotide.
Topics: Anti-HIV Agents; Chromatography, High Pressure Liquid; Drug Design; HIV; Nucleotides; Prodrugs; Virus Replication | 2001 |
Isolation and biological evaluation of filiformin, plakortide F, and plakortone G from the Caribbean sponge Plakortis sp.
Topics: Animals; Antimalarials; Bromobenzenes; Chromatography, High Pressure Liquid; Colonic Neoplasms; Dioxanes; Gas Chromatography-Mass Spectrometry; Hepatitis B; HIV; Humans; Jamaica; Lactones; Leukemia P388; Lung Neoplasms; Mice; Molecular Structure; Mycobacterium tuberculosis; Neoplasms, Unknown Primary; Nuclear Magnetic Resonance, Biomolecular; Plasmodium berghei; Plasmodium falciparum; Porifera; Spectrometry, Mass, Electrospray Ionization; Tumor Cells, Cultured | 2001 |
Synthesis and antiviral activity of C-fluoro-branched cyclopropyl nucleosides.
Topics: Antiviral Agents; Cells, Cultured; Cyclopropanes; Herpesvirus 1, Human; Herpesvirus 2, Human; HIV; Humans; Hydrocarbons, Fluorinated; Microbial Sensitivity Tests; Molecular Structure; Nucleosides | 2007 |
Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel thymidine analog.
Topics: Anti-HIV Agents; Cell Line; Dideoxynucleotides; Dose-Response Relationship, Drug; HeLa Cells; HIV; Humans; Phosphorylation; Reverse Transcriptase Inhibitors; Stavudine; Thymine Nucleotides; Virus Replication; Zidovudine | 2007 |
Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors.
Topics: Anti-HIV Agents; Caco-2 Cells; Cell Line, Tumor; Drug Evaluation, Preclinical; Enzyme-Linked Immunosorbent Assay; HIV; HIV Integrase Inhibitors; Humans; Indoles; Integrases; Molecular Structure; Polymerase Chain Reaction; Viral Proteins; Virus Replication | 2008 |
Studies on anti-HIV quinolones: new insights on the C-6 position.
Topics: Anti-HIV Agents; HIV; Humans; Quinolones; Structure-Activity Relationship; Transcription, Genetic; Virus Replication | 2009 |
Synthesis and antiviral evaluation of thieno[3,4-d]pyrimidine C-nucleoside analogues of 2',3'-dideoxy- and 2',3'-dideoxy-2',3'-didehydro-adenosine and -inosine.
Topics: Adenosine; Antiviral Agents; HIV; Inosine; Magnetic Resonance Spectroscopy; Pyrimidines; Spectrometry, Mass, Electrospray Ionization | 2009 |
Aryl nucleoside H-phosphonates. Part 16: synthesis and anti-HIV-1 activity of di-aryl nucleoside phosphotriesters.
Topics: Anti-HIV Agents; Cell Line; Cells, Cultured; HIV; Humans; Hydroxy Acids; Microbial Sensitivity Tests; Molecular Structure; Nucleosides; Nucleotides; Organophosphonates; Virus Replication | 2009 |
"Viologen" dendrimers as antiviral agents: the effect of charge number and distance.
Topics: Anti-HIV Agents; Antiviral Agents; Cell Line; Dendrimers; HIV; Humans; Static Electricity; Structure-Activity Relationship; Viologens | 2010 |
Synthesis and evaluation of beta-carboline derivatives as inhibitors of human immunodeficiency virus.
Topics: Anti-HIV Agents; Carbolines; Cell Line; Formates; HIV; Humans | 2010 |
Anti-HIV and antiplasmodial activity of original flavonoid derivatives.
Topics: Anti-HIV Agents; Antimalarials; Cell Line; Cell Survival; Flavonoids; HIV; HIV Infections; Humans; Malaria, Falciparum; Plasmodium falciparum | 2010 |
Compounds from Kadsura angustifolia with anti-HIV activity.
Topics: Anti-HIV Agents; Cell Line, Tumor; HIV; Humans; Kadsura; Magnetic Resonance Spectroscopy; Molecular Conformation; Plant Stems; Triterpenes | 2011 |
Asymmetric total synthesis of (+)- and (-)-clusianone and (+)- and (-)-clusianone methyl enol ether via ACC alkylation and evaluation of their anti-HIV activity.
Topics: Alkylation; Anti-HIV Agents; Benzophenones; Benzoquinones; Bridged Bicyclo Compounds; Cell Line; Ethers; HIV; Humans; Stereoisomerism | 2011 |
Conjugation of cell-penetrating peptides leads to identification of anti-HIV peptides from matrix proteins.
Topics: Amino Acid Sequence; Anti-HIV Agents; Cell Membrane Permeability; Cell-Penetrating Peptides; Circular Dichroism; HeLa Cells; HIV; Humans; Models, Molecular; Molecular Sequence Data; Peptide Library | 2012 |
Design, synthesis and antiviral activity of novel quinazolinones.
Topics: Antiviral Agents; Chemistry Techniques, Synthetic; Drug Design; HIV; Quinazolinones; Tobacco Mosaic Virus | 2012 |
Clicking 3'-azidothymidine into novel potent inhibitors of human immunodeficiency virus.
Topics: Anti-HIV Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; HIV; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Structure-Activity Relationship; Zidovudine | 2013 |
Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9-[(2-Phosphonomethoxy)ethyl]guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification.
Topics: Antiviral Agents; Cell Line, Tumor; DNA, Viral; Dose-Response Relationship, Drug; Guanine; HEK293 Cells; Herpesvirus 2, Human; HIV; Humans; Leukocytes, Mononuclear; Molecular Structure; Nucleic Acid Amplification Techniques; Organophosphonates; Papillomaviridae; Structure-Activity Relationship; Virus Replication | 2016 |
Indazolyl-substituted piperidin-4-yl-aminopyrimidines as HIV-1 NNRTIs: Design, synthesis and biological activities.
Topics: Anti-HIV Agents; Dose-Response Relationship, Drug; Drug Design; HIV; HIV Reverse Transcriptase; Humans; Indazoles; Microbial Sensitivity Tests; Molecular Structure; Piperidines; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship | 2020 |
Exploratory studies on CA-15L, an anti-HIV active HIV-1 capsid fragment.
Topics: Anti-HIV Agents; Capsid Proteins; Dose-Response Relationship, Drug; HIV; Humans; Microbial Sensitivity Tests; Molecular Structure; Peptide Fragments; Structure-Activity Relationship | 2020 |
Design, synthesis and anti-HIV evaluation of novel 5-substituted diarylpyrimidine derivatives as potent HIV-1 NNRTIs.
Topics: Anti-HIV Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Design; HIV; HIV Reverse Transcriptase; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship | 2021 |
Tigliane-Type Diterpene Esters from the Fruits of
Topics: Anti-HIV Agents; Cell Line; Euphorbiaceae; Fruit; HIV; Humans; Molecular Structure; Phorbol Esters | 2022 |
Rapid simultaneous analysis of anti human immunodeficiency virus drugs in pharmaceutical formulation by smart spectrophotometry based on multivariate calibration and least squares support vector machine methods.
Topics: Calibration; Drug Compounding; HIV; Lamivudine; Least-Squares Analysis; Spectrophotometry; Support Vector Machine; Zidovudine | 2023 |
Cryptococcal meningitis and immune reconstitution inflammatory syndrome in a pediatric patient with HIV after switching to second line antiretroviral therapy: a case report.
Topics: AIDS-Related Opportunistic Infections; Alkynes; Anti-HIV Agents; Antifungal Agents; Antigens, Fungal; Benzoxazines; Child; Cryptococcus neoformans; Cyclopropanes; Dideoxynucleosides; Drug Combinations; Female; Fluconazole; HIV; Humans; Immune Reconstitution Inflammatory Syndrome; Lamivudine; Lopinavir; Meningitis, Cryptococcal; Ritonavir; Treatment Outcome; Viral Load; Zidovudine | 2020 |
High rates of tenofovir failure in a CRF01_AE-predominant HIV epidemic in the Philippines.
Topics: Adult; Anti-HIV Agents; Drug Resistance, Viral; Drug Therapy, Combination; Epidemics; Female; HIV; HIV Infections; Humans; Male; Philippines; Tenofovir; Treatment Failure; Viral Load; Zidovudine | 2020 |
Case report: one case of coronavirus disease 2019 (COVID-19) in a patient co-infected by HIV with a normal CD4
Topics: Alkynes; Anti-Retroviral Agents; Benzoxazines; Betacoronavirus; C-Reactive Protein; CD4 Lymphocyte Count; Chills; Coronavirus Infections; COVID-19; Cyclopropanes; Fatigue; Female; Fever; HIV; HIV Infections; Humans; Immunocompromised Host; Immunoglobulin M; Lamivudine; Middle Aged; Pandemics; Pharyngitis; Pneumonia, Viral; Real-Time Polymerase Chain Reaction; SARS-CoV-2; Sputum; Time Factors; Tomography, X-Ray Computed; Virus Shedding; Zidovudine | 2020 |
Prevalence and evaluation of risk factors of anti-retroviral therapy failure among human immunodeficiency virus/acquired immune deficiency syndrome patients in North India.
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; CD4 Lymphocyte Count; HIV; HIV Infections; Humans; India; Lamivudine; Male; Prevalence; Risk Factors; Viral Load; Zidovudine | 2021 |
Encapsulation of zidovudine in PF-68 coated alginate conjugate nanoparticles for anti-HIV drug delivery.
Topics: Alginates; Amides; Anti-HIV Agents; Chitosan; Drug Carriers; Drug Delivery Systems; Glucuronic Acid; Hexuronic Acids; HIV; HIV Infections; Humans; Nanoparticles; Zidovudine | 2018 |
HBV, HCV, and HBV/HCV co-infection among HIV-positive patients in Hunan province, China: Regimen selection, hepatotoxicity, and antiretroviral therapy outcome.
Topics: Adult; Alkynes; Anti-Retroviral Agents; Benzoxazines; CD4 Lymphocyte Count; Chemical and Drug Induced Liver Injury; Cohort Studies; Coinfection; Cyclopropanes; Female; Hepatitis B; Hepatitis C; HIV; HIV Infections; Humans; Male; Middle Aged; Nevirapine; Retrospective Studies; Treatment Outcome; Viral Load; Zidovudine | 2018 |
Impact of Timing of Antiretroviral Treatment and Birth Weight on Mother-to-Child Human Immunodeficiency Virus Transmission: Findings From an 18-Month Prospective Cohort of a Nationally Representative Sample of Mother-Infant Pairs During the Transition Fro
Topics: Adolescent; Adult; Anti-HIV Agents; Birth Weight; Breast Feeding; Female; HIV; HIV Infections; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Mothers; Pregnancy; Pregnancy Complications, Infectious; Prospective Studies; Time Factors; Zidovudine; Zimbabwe | 2018 |
Adherence, virological outcome, and drug resistance in Chinese HIV patients receiving first-line antiretroviral therapy from 2011 to 2015.
Topics: Adult; Anti-HIV Agents; China; Drug Resistance, Viral; Female; HIV; HIV Infections; Humans; Lamivudine; Male; Medication Adherence; Middle Aged; Retrospective Studies; Stavudine; Sustained Virologic Response; Tenofovir; Zidovudine | 2018 |
Cardiometabolic risk factors among HIV patients on antiretroviral therapy.
Topics: Adenine; Adolescent; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Cyclopropanes; Female; HIV; HIV Infections; Humans; Insulin Resistance; Lamivudine; Male; Middle Aged; Nevirapine; Organophosphonates; Risk Factors; Stavudine; Tenofovir; Triglycerides; Zambia; Zidovudine | 2013 |
Comparison of tenofovir, zidovudine, or stavudine as part of first-line antiretroviral therapy in a resource-limited-setting: a cohort study.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Cohort Studies; Female; Health Resources; HIV; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Residence Characteristics; RNA, Viral; Stavudine; Tenofovir; Young Adult; Zidovudine | 2013 |
Clinical manifestations and treatment outcomes in HIV-1-infected children receiving antiretroviral therapy in Karachi, Pakistan.
Topics: Anti-HIV Agents; Body Height; Body Weight; CD4 Lymphocyte Count; Child, Preschool; Drug Resistance, Viral; Female; Genotype; HIV; HIV Infections; Humans; Infant; Lamivudine; Male; Nevirapine; Pakistan; Retrospective Studies; Reverse Transcriptase Inhibitors; Treatment Outcome; Viral Load; Zidovudine | 2014 |
MicroRNA-150 is a potential biomarker of HIV/AIDS disease progression and therapy.
Topics: Acquired Immunodeficiency Syndrome; Adult; Alkynes; Antiretroviral Therapy, Highly Active; Benzoxazines; Biomarkers; CD4 Lymphocyte Count; Cyclopropanes; Disease Progression; Drug Resistance, Viral; Female; Gene Expression Regulation; HIV; Humans; Lamivudine; Leukocytes, Mononuclear; Male; MicroRNAs; Nevirapine; Stavudine; Treatment Outcome; Viral Load; Zidovudine | 2014 |
[HIV encephalopathy due to drug resistance despite 2-year suppression of HIV viremia by cART].
Topics: AIDS Dementia Complex; Anti-Retroviral Agents; Central Nervous System; Cognition Disorders; Darunavir; Disease Progression; Drug Resistance, Viral; Drug Substitution; HIV; HIV Infections; Humans; Male; Middle Aged; Pyrrolidinones; Raltegravir Potassium; Ritonavir; RNA, Viral; Sulfonamides; Time Factors; Viremia; Zidovudine | 2014 |
Is zidovudine first-line therapy virologically comparable to tenofovir in resource-limited settings?
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cross-Sectional Studies; Cyclopropanes; Female; Health Resources; HIV; HIV Infections; Humans; Lamivudine; Lesotho; Logistic Models; Male; Middle Aged; Organophosphonates; Tenofovir; Viral Load; Zidovudine | 2015 |
Plasma Mitochondrial DNA Levels as a Biomarker of Lipodystrophy Among HIV-infected Patients Treated with Highly Active Antiretroviral Therapy (HAART).
Topics: Adult; Alkynes; Antiretroviral Therapy, Highly Active; Benzoxazines; Biomarkers; Case-Control Studies; Cyclopropanes; DNA, Mitochondrial; Drug Combinations; Female; HIV; HIV Infections; Humans; Lamivudine; Lipodystrophy; Lopinavir; Male; Middle Aged; Mitochondria; Nelfinavir; Predictive Value of Tests; Ritonavir; ROC Curve; Stavudine; Zidovudine | 2015 |
HIV therapy with unknown HBV status is responsible for higher rate of HBV genome variability in Ethiopia.
Topics: Adult; Alkynes; Antiretroviral Therapy, Highly Active; Benzoxazines; Coinfection; Cyclopropanes; DNA, Viral; Drug Resistance, Viral; Ethiopia; Female; Genetic Variation; Genome, Viral; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV; HIV Infections; Humans; Immune Evasion; Lamivudine; Male; Mutation; Stavudine; Viral Load; Zidovudine | 2017 |
Early infant diagnosis of HIV infection using DNA-PCR at a referral center: an 8 years retrospective analysis.
Topics: Anti-HIV Agents; DNA, Viral; Early Diagnosis; Ethiopia; Female; HIV; HIV Infections; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Male; Nevirapine; Polymerase Chain Reaction; Pregnancy; Pregnancy Complications, Infectious; Retrospective Studies; Risk Factors; Zidovudine | 2016 |
First-line antiretroviral drug discontinuations in children.
Topics: Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; Child; Child, Preschool; Cyclopropanes; Dideoxynucleosides; Drug Combinations; Follow-Up Studies; HIV; HIV Infections; Humans; Infant; Kaplan-Meier Estimate; Lopinavir; Outcome Assessment, Health Care; Proportional Hazards Models; Ritonavir; South Africa; Stavudine; Withholding Treatment; Zidovudine | 2017 |
Breast-feeding, antiretroviral prophylaxis, and HIV.
Topics: Anti-HIV Agents; Breast Feeding; Female; HIV; HIV Infections; Humans; Infant; Infectious Disease Transmission, Vertical; Nevirapine; Weaning; Zidovudine | 2008 |
Restoration of the antiviral activity of 3'-azido-3'-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus by delivery of engineered thymidylate kinase to T cells.
Topics: Anti-HIV Agents; CD4-Positive T-Lymphocytes; Cell Line; Drug Resistance, Viral; HIV; HIV Core Protein p24; Humans; Kinetics; Models, Molecular; Nucleoside-Phosphate Kinase; Protein Structure, Tertiary; Virus Replication; Zidovudine | 2008 |
Synthesis and in vitro activities of a new antiviral duplex drug linking Zidovudine (AZT) and Foscarnet (PFA) via an octadecylglycerol residue.
Topics: Antiviral Agents; Cross-Linking Reagents; Cytomegalovirus; Drug Interactions; Foscarnet; Glyceryl Ethers; HIV; Humans; Inhibitory Concentration 50; Simplexvirus; Zidovudine | 2009 |
Development of a liquid chromatographic assay for an anti-HIV tablet containing lamivudine, zidovudine and TMC278.HCL.
Topics: Anti-HIV Agents; Biological Assay; Calibration; Chemistry, Pharmaceutical; Chromatography, Liquid; HIV; Humans; Lamivudine; Light; Molecular Structure; Nitriles; Pyrimidines; Reference Standards; Rilpivirine; Scattering, Radiation; Sensitivity and Specificity; Solvents; Spectrophotometry, Ultraviolet; Tablets; Zidovudine | 2009 |
Pharmacokinetic-pharmacodynamic relationship of NRTIs and its connection to viral escape: an example based on zidovudine.
Topics: Animals; Clinical Trials as Topic; Drug Resistance, Viral; HIV; Humans; Mutation; Reverse Transcriptase Inhibitors; Zidovudine | 2009 |
Resistance to antiretrovirals in HIV-infected pregnant women.
Topics: Adult; Anti-HIV Agents; Data Interpretation, Statistical; Drug Resistance, Viral; Female; HIV; HIV Infections; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Lamivudine; Mutation; Pregnancy; Pregnancy Complications, Infectious; Retrospective Studies; Viral Load; Zidovudine | 2009 |
Rate of accumulation of thymidine analogue mutations in patients continuing to receive virologically failing regimens containing zidovudine or stavudine: implications for antiretroviral therapy programs in resource-limited settings.
Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Resistance, Viral; Female; HIV; HIV Infections; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Mutation, Missense; Stavudine; Young Adult; Zidovudine | 2009 |
A medical mission to Swaziland, part 2.
Topics: Correspondence as Topic; Delivery of Health Care; Eswatini; Gynecologic Surgical Procedures; Gynecology; History, 20th Century; HIV; Medical Missions; Mortality; Physicians; Travel; Zidovudine | 2000 |
Evaluating patients for second-line antiretroviral therapy in India: the role of targeted viral load testing.
Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Female; HIV; HIV Infections; Humans; India; Lamivudine; Male; Middle Aged; Nevirapine; RNA, Viral; Stavudine; Treatment Failure; Viral Load; Zidovudine | 2010 |
Reduced dose of stavudine and lipoatrophy in HIV-infected patients in Cameroon.
Topics: Adult; Anti-HIV Agents; Cameroon; CD4 Lymphocyte Count; Cross-Sectional Studies; Female; HIV; HIV Infections; Humans; Lamivudine; Lipodystrophy; Male; Middle Aged; Nevirapine; Stavudine; Zidovudine | 2010 |
Adherence to combination prophylaxis for prevention of mother-to-child-transmission of HIV in Tanzania.
Topics: Adolescent; Adult; Delivery, Obstetric; Drug Therapy, Combination; Female; HIV; HIV Infections; Hospitals; Humans; Infectious Disease Transmission, Vertical; Mothers; Patient Compliance; Pregnancy; Rural Population; Tanzania; Time Factors; Young Adult; Zidovudine | 2011 |
Marvellous chemical biology tools and other matters.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Computational Biology; Drug Design; HIV; Humans; Zidovudine | 2012 |
Interleukin-8 in the pathogenesis of primary central nervous system lymphoma in association with HIV infection.
Topics: Anti-HIV Agents; CD18 Antigens; Cell Adhesion; Cell Line, Transformed; Cell Line, Tumor; Central Nervous System Neoplasms; Herpesvirus 4, Human; HIV; Humans; Intercellular Adhesion Molecule-1; Interleukin-8; Lymphoma, AIDS-Related; Simvastatin; Zidovudine | 2012 |
Expression of oral secretory leukocyte protease inhibitor in HIV-infected subjects with long-term use of antiretroviral therapy.
Topics: Adult; Alcohol Drinking; Anti-HIV Agents; Anti-Retroviral Agents; Biomarkers; CD4 Lymphocyte Count; Cross-Sectional Studies; Female; Gingival Hemorrhage; HIV; HIV Infections; Humans; Male; Middle Aged; Mouth Mucosa; Oral Health; Periodontal Pocket; Saliva; Salivary Proteins and Peptides; Secretory Leukocyte Peptidase Inhibitor; Secretory Rate; Serine Proteinase Inhibitors; Smoking; Time Factors; Viral Load; Young Adult; Zidovudine | 2013 |
Inhibition of telomerase activity by human immunodeficiency virus (HIV) nucleos(t)ide reverse transcriptase inhibitors: a potential factor contributing to HIV-associated accelerated aging.
Topics: Adenine; Adult; Aging; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Case-Control Studies; Cells, Cultured; Deoxycytidine; Dideoxynucleosides; Emtricitabine; Enzyme Activation; Female; HIV; HIV Infections; Humans; Lamivudine; Leukocytes, Mononuclear; Male; Middle Aged; Organophosphonates; Polymerase Chain Reaction; Regression Analysis; Reverse Transcriptase Inhibitors; Risk Factors; Telomerase; Telomere; Telomere Shortening; Tenofovir; Time Factors; Young Adult; Zidovudine | 2013 |
Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11.
Topics: Anti-HIV Agents; ATP-Binding Cassette Transporters; Biological Transport; Deoxycytidine Kinase; Drug Resistance, Multiple; HIV; Humans; Lamivudine; Multidrug Resistance-Associated Proteins; Nucleosides; T-Lymphocytes; Tumor Cells, Cultured; Zidovudine | 2002 |
Selection of a T-cell line resistant to stavudine and zidovudine by prolonged treatment with stavudine.
Topics: Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV; Humans; Phosphorylation; RNA, Messenger; Stavudine; T-Lymphocytes; Thymidine Kinase; Time Factors; Zidovudine | 2002 |
Loss of zidovudine related mutations in the reverse transscriptase gene of HIV after switching therapy.
Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Drug Administration Schedule; Drug Resistance, Viral; Genotype; HIV; HIV Infections; HIV Reverse Transcriptase; Humans; Mutation; Reverse Transcriptase Inhibitors; Treatment Outcome; Viral Load; Zidovudine | 2002 |
Prenatal HIV counseling, testing, and antiretroviral prophylaxis by obstetric and family medicine providers in Alabama.
Topics: AIDS Serodiagnosis; Alabama; Anti-HIV Agents; Directive Counseling; Family Practice; Female; HIV; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Patient Acceptance of Health Care; Patient Education as Topic; Perinatal Care; Practice Patterns, Physicians'; Pregnancy; Pregnancy Complications, Infectious; Prenatal Care; Preventive Health Services; United States; Zidovudine | 2002 |
Recommendations to reduce the risk of occupational HIV transmission.
Topics: Anti-HIV Agents; Health Occupations; HIV; HIV Infections; Humans; Infectious Disease Transmission, Patient-to-Professional; New Jersey; Occupational Diseases; Practice Guidelines as Topic; Risk; Zidovudine | 2003 |
Synthesis and evaluation of novel bioconjugates as antiviral agents.
Topics: Anti-HIV Agents; Base Sequence; DNA, Viral; HIV; Lipids; Molecular Structure; Nucleosides; Oligodeoxyribonucleotides; Zidovudine | 2000 |
Synthesis and antiviral activity of some 5'-N-phthaloyl-3'-azido-2',3'-dideoxythymidine analogues.
Topics: Animals; Anti-HIV Agents; Cell Transformation, Viral; Cells, Cultured; HIV; Humans; Imides; Mice; Microbial Sensitivity Tests; Prodrugs; Reverse Transcriptase Inhibitors; Sarcoma Viruses, Murine; Virus Replication; Zidovudine | 2003 |
In vitro activity of stampidine against primary clinical human immunodeficiency virus isolates.
Topics: Cells, Cultured; Dideoxynucleotides; Drug Resistance, Viral; Genotype; HIV; HIV Infections; HIV-1; Humans; Lamivudine; Mutation; Neutrophils; Phenotype; Reverse Transcriptase Inhibitors; Stavudine; Thymidine Monophosphate; Viral Plaque Assay; Zidovudine | 2004 |
Modelling HIV-RNA viral load in vertically infected children.
Topics: Algorithms; Europe; Female; HIV; HIV Infections; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Male; Models, Statistical; RNA, Viral; Viral Load; Zidovudine | 2004 |
Can the peripheral blood monocyte count be used as a marker of CSF resistance to antiretroviral drugs?
Topics: Anti-HIV Agents; Biomarkers; Buffers; Culture Media; Dideoxynucleosides; Drug Resistance, Viral; HIV; HIV Infections; Humans; In Vitro Techniques; Leukocyte Count; Monocytes; Stavudine; Zidovudine | 2004 |
Synthesis and evaluation of a novel synthetic phosphocholine lipid-AZT conjugate that double-targets wild-type and drug resistant variants of HIV.
Topics: Antiviral Agents; Drug Resistance, Viral; HIV; HIV Infections; Humans; Malonates; Phosphorylcholine; Zidovudine | 2004 |
Phenotypic impact of HIV reverse transcriptase M184I/V mutations in combination with single thymidine analog mutations on nucleoside reverse transcriptase inhibitor resistance.
Topics: Adenine; Algorithms; Anti-HIV Agents; Databases, Genetic; Didanosine; Dideoxynucleosides; Drug Resistance, Multiple, Viral; HIV; HIV Infections; Humans; Mutation; Organophosphonates; Organophosphorus Compounds; Phenotype; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Thymidine; Zalcitabine; Zidovudine | 2004 |
Simultaneous determination of the HIV nucleoside analogue reverse transcriptase inhibitors lamivudine, didanosine, stavudine, zidovudine and abacavir in human plasma by reversed phase high performance liquid chromatography.
Topics: Anti-HIV Agents; Chromatography, High Pressure Liquid; Didanosine; Dideoxynucleosides; Drug Stability; HIV; HIV Infections; Humans; Lamivudine; Quality Control; Reproducibility of Results; Reverse Transcriptase Inhibitors; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stavudine; Zidovudine | 2005 |
Thymidine kinase and deoxycytidine kinase activity in mononuclear cells from antiretroviral-naive HIV-infected patients.
Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Deoxycytidine Kinase; Female; HIV; HIV Infections; Humans; Leukocytes, Mononuclear; Male; Middle Aged; RNA, Viral; Thymidine; Thymidine Kinase; Zidovudine | 2005 |
Homo and heterodimers of ddI, d4T and AZT: influence of (5'-5') thiolcabonate-carbamate linkage on anti-HIV activity.
Topics: Anti-HIV Agents; Antiviral Agents; Carbamates; Didanosine; Dimerization; HIV; HIV Infections; Models, Chemical; Molecular Conformation; Mutation; Stavudine; Sulfhydryl Compounds; Zidovudine | 2005 |
Aryl nucleoside H-phosphonates. Part 15: Synthesis, properties and, anti-HIV activity of aryl nucleoside 5'-alpha-hydroxyphosphonates.
Topics: Anti-HIV Agents; Cell Line; Cells, Cultured; HIV; Humans; Hydroxy Acids; Microbial Sensitivity Tests; Molecular Structure; Organophosphonates; Virus Replication; Zidovudine | 2006 |
Tenofovir DF and emtricitabine vs. zidovudine and lamivudine.
Topics: Adenine; Bone Density; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; HIV; HIV Infections; Humans; Lamivudine; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Zidovudine | 2006 |
C34, a membrane fusion inhibitor, blocks HIV infection of langerhans cells and viral transmission to T cells.
Topics: Anti-HIV Agents; Antigens, CD34; Cells, Cultured; Chemokine CCL5; Coculture Techniques; Epidermal Cells; Epidermis; Gene Products, gag; HIV; HIV Envelope Protein gp41; HIV Infections; Humans; Langerhans Cells; Membrane Fusion; T-Lymphocytes; Virus Integration; Zidovudine | 2007 |
Prior antiretroviral therapy experience protects against zidovudine-related anaemia.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anemia; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Asia; Developing Countries; Drug Therapy, Combination; Female; HIV; HIV Infections; Humans; Male; Middle Aged; Multivariate Analysis; Retrospective Studies; Zidovudine | 2007 |
Decreasing CD4+ T-cell count during suppressed or low-level viraemia in patients with HIV infection.
Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Case-Control Studies; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Female; HIV; HIV Infections; Humans; Male; RNA, Viral; Stavudine; Viral Load; Viremia; Zidovudine | 2007 |
Frequent detection of acute HIV infection in pregnant women.
Topics: Acute Disease; Algorithms; Anti-HIV Agents; Female; Follow-Up Studies; HIV; HIV Infections; HIV Seropositivity; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Mass Screening; North Carolina; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Pregnancy Trimester, Second; Prenatal Care; Prevalence; RNA, Viral; Zidovudine | 2007 |
Characteristics of untreated AIDS-related cytomegalovirus retinitis. II. Findings in the era of highly active antiretroviral therapy (1997 to 2000).
Topics: Acyclovir; Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; Antiviral Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cytomegalovirus Retinitis; Drug Therapy, Combination; Female; HIV; Humans; Los Angeles; Male; Retrospective Studies; RNA, Viral; Urban Population; Zidovudine | 2008 |
Predictors of severe haematological toxicity secondary to pegylated interferon plus ribavirin treatment in HIV-HCV-coinfected patients.
Topics: Adult; Anemia; Antiviral Agents; Biomarkers; Drug Therapy, Combination; Female; Fibrosis; Hepatitis C, Chronic; HIV; HIV Infections; Humans; Injections, Subcutaneous; Interferon alpha-2; Interferon-alpha; Leukocyte Count; Male; Neutropenia; Platelet Count; Polyethylene Glycols; Recombinant Proteins; Retrospective Studies; Ribavirin; Risk Factors; Spain; Thrombocytopenia; Zidovudine | 2007 |
Short communication cellular pharmacology of 9-(beta-D-1,3-dioxolan-4-yl) guanine and its lack of drug interactions with zidovudine in primary human lymphocytes.
Topics: Cells, Cultured; Dioxolanes; Dose-Response Relationship, Drug; Drug Interactions; Guanine; Half-Life; HIV; Humans; Lymphocytes; Mutation; Phosphorylation; Prodrugs; Zidovudine | 2007 |
Rapid scaling-up of antiretroviral therapy in 10,000 adults in Côte d'Ivoire: 2-year outcomes and determinants.
Topics: Adult; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cote d'Ivoire; Drug Administration Schedule; Female; Follow-Up Studies; HIV; HIV Infections; HIV-1; HIV-2; Humans; Lamivudine; Male; Nevirapine; Survival Analysis; Treatment Outcome; Zidovudine | 2008 |
25 years of HIV.
Topics: AIDS Vaccines; Anti-HIV Agents; Drug Resistance, Viral; History, 20th Century; History, 21st Century; HIV; HIV Infections; Humans; Time Factors; Zidovudine | 2008 |
Is HIV the cause of AIDS?
Topics: Acquired Immunodeficiency Syndrome; Antibodies, Viral; Female; Hemophilia A; HIV; HIV Infections; Humans; Male; Zidovudine | 1995 |
[HIV drug resistance and its genetic basis].
Topics: Amino Acid Sequence; Codon; Didanosine; Drug Resistance, Microbial; HIV; Molecular Sequence Data; Mutation; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Zidovudine | 1993 |
Combinative interactions of a human immunodeficiency virus (HIV) Tat antagonist with HIV reverse transcriptase inhibitors and an HIV protease inhibitor.
Topics: Antiviral Agents; Benzodiazepines; Didanosine; Drug Synergism; Gene Products, tat; HeLa Cells; HIV; HIV Protease Inhibitors; Humans; Isoquinolines; Nevirapine; Pyridines; Pyrroles; Quinolines; Reverse Transcriptase Inhibitors; Saquinavir; tat Gene Products, Human Immunodeficiency Virus; Zalcitabine; Zidovudine | 1994 |
Didanosine resistance in HIV-infected patients switched from zidovudine to didanosine monotherapy.
Topics: CD4-Positive T-Lymphocytes; Codon; Didanosine; Drug Resistance, Microbial; Genes, Viral; HIV; HIV Infections; Humans; Leukocyte Count; Mutation; Retrospective Studies; RNA-Directed DNA Polymerase; RNA, Viral; Zidovudine | 1994 |
Human immunodeficiency virus reverse transcriptase substitutes for DNA polymerase I in Escherichia coli.
Topics: DNA Polymerase I; DNA Replication; Drug Evaluation, Preclinical; Escherichia coli; Genetic Complementation Test; HIV; Humans; Mutation; Plasmids; RNA-Directed DNA Polymerase; Temperature; Zidovudine | 1995 |
A screen in Escherichia coli for nucleoside analogs that target human immunodeficiency virus (HIV) reverse transcriptase: coexpression of HIV reverse transcriptase and herpes simplex virus thymidine kinase.
Topics: Antiviral Agents; Cloning, Molecular; Cytarabine; DNA Polymerase I; Drug Evaluation, Preclinical; Escherichia coli; Gene Expression; HIV; Kinetics; Phosphorylation; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Simplexvirus; Thymidine Kinase; Zalcitabine; Zidovudine | 1995 |
Effect of zidovudine and didanosine treatment on heart function in children infected with human immunodeficiency virus.
Topics: Acquired Immunodeficiency Syndrome; Cardiomyopathies; CD4 Lymphocyte Count; Child, Preschool; Didanosine; Dose-Response Relationship, Drug; Echocardiography; Female; Heart; HIV; Humans; Infant; Infant, Newborn; Male; Medical Records; Retrospective Studies; Severity of Illness Index; Zalcitabine; Zidovudine | 1995 |
Correlation of clinical progression in human immunodeficiency virus-infected children with in vitro zidovudine resistance measured by a direct quantitative peripheral blood lymphocyte assay.
Topics: Child; Child, Preschool; Disease Progression; Drug Resistance, Microbial; Follow-Up Studies; HIV; HIV Core Protein p24; HIV Infections; Humans; Infant; Lymphocytes; Microbial Sensitivity Tests; Zidovudine | 1995 |
Efficient incorporation of anti-HIV deoxynucleotides by recombinant yeast mitochondrial DNA polymerase.
Topics: Antiviral Agents; Base Sequence; Deoxyribonucleotides; Dideoxynucleotides; DNA-Directed DNA Polymerase; HIV; Mitochondria; Molecular Sequence Data; Recombinant Proteins; Saccharomyces cerevisiae; Substrate Specificity; Thymine Nucleotides; Zidovudine | 1995 |
A mutation in human immunodeficiency virus reverse transcriptase and decline in CD4 lymphocyte numbers in long-term zidovudine recipients.
Topics: CD4-Positive T-Lymphocytes; Codon; DNA, Viral; Drug Resistance; Genes, pol; HIV; HIV Infections; Humans; Leukocyte Count; Longitudinal Studies; Point Mutation; Polymerase Chain Reaction; Proviruses; RNA-Directed DNA Polymerase; RNA, Viral; Zidovudine | 1993 |
Triple whammy. Will an AIDS therapy live up to its advance billing?
Topics: Acquired Immunodeficiency Syndrome; Cells, Cultured; Didanosine; Drug Therapy, Combination; HIV; Humans; Nevirapine; Pyridines; Pyridones; Reverse Transcriptase Inhibitors; Virus Replication; Zidovudine | 1993 |
Early identification of human immunodeficiency virus-infected asymptomatic subjects susceptible to zidovudine by quantitative viral coculture and reverse transcription-linked polymerase chain reaction.
Topics: Base Sequence; DNA, Viral; HIV; HIV Seropositivity; Humans; Molecular Sequence Data; Monocytes; Polymerase Chain Reaction; RNA-Directed DNA Polymerase; Transcription, Genetic; Zidovudine | 1993 |
Can combination therapy overcome drug resistance?
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Drug Resistance, Microbial; Drug Therapy, Combination; HIV; Humans; RNA-Directed DNA Polymerase; Zidovudine | 1993 |
AIDS drugs. Harvard group makes a splash--twice.
Topics: Antiviral Agents; Didanosine; HIV; Mutation; Nevirapine; Pyridines; Reverse Transcriptase Inhibitors; Virus Replication; Zidovudine | 1993 |
Resisting the temptation.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Didanosine; Drug Combinations; HIV; Humans; Nevirapine; Pyridines; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Virus Replication; Zidovudine | 1993 |
[Inhibition of human immunodeficiency virus replication by azidothymidine (Azitidín Lachema) in cultured cells].
Topics: Cell Line; Cytopathogenic Effect, Viral; HIV; HIV Antigens; Humans; RNA-Directed DNA Polymerase; Virus Replication; Zidovudine | 1993 |
Evaluation of the combination effect of different antiviral compounds against HIV in vitro.
Topics: Antiviral Agents; Benzodiazepines; Didanosine; Dideoxynucleosides; Drug Combinations; Drug Evaluation; Drug Synergism; HIV; Humans; Imidazoles; Microbial Sensitivity Tests; Reverse Transcriptase Inhibitors; Stavudine; Zidovudine | 1993 |
Phosphatidylazidothymidine and phosphatidyl-ddC: assessment of uptake in mouse lymphoid tissues and antiviral activities in human immunodeficiency virus-infected cells and in Rauscher leukemia virus-infected mice.
Topics: Animals; Female; HIV; Lymphoid Tissue; Mice; Mice, Inbred BALB C; Phospholipids; Prodrugs; Rauscher Virus; Zalcitabine; Zidovudine | 1994 |
Determination of human immunodeficiency virus RNA in plasma and cellular viral DNA genotypic zidovudine resistance and viral load during zidovudine-didanosine combination therapy.
Topics: Base Sequence; Didanosine; DNA, Viral; Drug Resistance, Microbial; Drug Therapy, Combination; Genotype; HIV; HIV Infections; Humans; Molecular Sequence Data; RNA, Viral; Zidovudine | 1995 |
Serum HIV-1 RNA and routine patient monitoring.
Topics: Drug Resistance; HIV; HIV Infections; Humans; Zidovudine | 1995 |
Synthesis of a photoaffinity analog of 3'-azidothymidine, 5-azido-3'-azido-2',3'-dideoxyuridine. Interactions with herpesvirus thymidine kinase and cellular enzymes.
Topics: Affinity Labels; Animals; Antiviral Agents; Herpesvirus 1, Human; HIV; Microsomes, Liver; Rats; Thymidine Kinase; Zidovudine | 1995 |
The predictive value of T cell function in vitro and pre-AIDS zidovudine use for survival after AIDS diagnosis in a cohort of homosexual men in Amsterdam.
Topics: Acquired Immunodeficiency Syndrome; Adult; Age Factors; Analysis of Variance; Antigens, CD; Biomarkers; CD4-CD8 Ratio; Cells, Cultured; Cohort Studies; Follow-Up Studies; HIV; HIV Seropositivity; Homosexuality, Male; Humans; Lymphocyte Activation; Male; Multivariate Analysis; Netherlands; Predictive Value of Tests; Prognosis; Prospective Studies; Survival Analysis; T-Lymphocyte Subsets; T-Lymphocytes; Time Factors; Zidovudine | 1995 |
Mathematical modelling of chemotherapy in HIV infection.
Topics: CD4 Lymphocyte Count; HIV; HIV Infections; Humans; Models, Biological; Survival Analysis; Virus Replication; Zidovudine | 1994 |
Synthesis of some new 1,6-dihydro-3-substituted 6-spiro-(9'-fluorene)-1,2,4-triazin-5-(4H)-ones as potential anti HIV and anticancer drugs.
Topics: Antineoplastic Agents; Antiviral Agents; Drug Screening Assays, Antitumor; HIV; Humans; Spiro Compounds; Triazines; Tumor Cells, Cultured; Zidovudine | 1994 |
"The Duesberg phenomenon": Duesberg and other voices.
Topics: Acquired Immunodeficiency Syndrome; HIV; Homosexuality, Male; Humans; Male; Research; Zidovudine | 1995 |
Synthesis of some new heterobicyclic compounds containing spiro-1,2,4-triazine moiety as potential anti-HIV and anticancer agents.
Topics: Antineoplastic Agents; Antiviral Agents; HIV; Magnetic Resonance Spectroscopy; Mass Spectrometry; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Triazines; Tumor Cells, Cultured; Zidovudine | 1994 |
AIDS mood upbeat--for a change.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Drug Therapy, Combination; Gene Products, nef; Herpesviridae; HIV; Humans; Lamivudine; nef Gene Products, Human Immunodeficiency Virus; Sarcoma, Kaposi; Simian Immunodeficiency Virus; Virus Replication; Zalcitabine; Zidovudine | 1995 |
Quasispecies dynamics and the emergence of drug resistance during zidovudine therapy of HIV infection.
Topics: CD4-Positive T-Lymphocytes; Didanosine; Drug Resistance, Microbial; Drug Therapy, Combination; Genes, pol; HIV; HIV Infections; Humans; Leukocyte Count; Models, Biological; Mutation; Population Dynamics; Species Specificity; Virus Replication; Zidovudine | 1994 |
Inhibitory effect of the oral immune response modifier, bestatin, on cell-mediated and cell-free HIV infection in vitro.
Topics: Anti-Bacterial Agents; CD4-Positive T-Lymphocytes; Cell Division; Cell-Free System; Dextran Sulfate; HIV; HIV Infections; Immunity, Cellular; Immunologic Factors; In Vitro Techniques; Leucine; Virus Replication; Zidovudine | 1994 |
Quantification of HIV by PCR in monocytes and lymphocytes in patients receiving antiviral treatment and low dose recombinant human granulocyte macrophage colony stimulating factor.
Topics: Adult; Autoradiography; DNA, Viral; Drug Administration Schedule; Female; Granulocyte-Macrophage Colony-Stimulating Factor; HIV; HIV Infections; Humans; Lymphocytes; Male; Monocytes; Pilot Projects; Polymerase Chain Reaction; Zidovudine | 1994 |
The Duesberg phenomenon.
Topics: Acquired Immunodeficiency Syndrome; History, 20th Century; HIV; Humans; Illicit Drugs; Publishing; Zidovudine | 1994 |
Anti-HIV michellamines from Ancistrocladus korupensis.
Topics: Africa; Antiviral Agents; Cells, Cultured; Drug Interactions; HIV; HIV-1; HIV-2; Humans; Isoquinolines; Microbial Sensitivity Tests; Molecular Structure; Naphthalenes; Plants; Virus Replication; Zidovudine | 1994 |
Synthesis and antiviral activity of 3'-azido-3'-deoxythymidine triphosphate distearoylglycerol: a novel phospholipid conjugate of the anti-HIV agent AZT.
Topics: Antiviral Agents; Dideoxynucleotides; HeLa Cells; HIV; HIV Infections; Humans; Phosphatidic Acids; Zidovudine | 1994 |
Transmission of zidovudine-resistant HIV during a bloody fight.
Topics: Adult; Drug Resistance, Microbial; HIV; HIV Infections; Humans; Male; Violence; Zidovudine | 1994 |
Equal inhibition of the replication of human immunodeficiency virus in human T-cell culture by ddA bis(SATE)phosphotriester and 3'-azido-2',3'-dideoxythymidine.
Topics: Antiviral Agents; Cell Line; Dideoxyadenosine; Drug Evaluation, Preclinical; HIV; Humans; T-Lymphocytes; Virus Replication; Zidovudine | 1994 |
A screening model of anti-HIV non AZT cross resistance virostatics.
Topics: Antiviral Agents; Drug Resistance; HIV; Humans; Mass Screening; Models, Statistical; Virology; Zidovudine | 1993 |
In vitro activity of inhibitors of late stages of the replication of HIV in chronically infected macrophages.
Topics: Cells, Cultured; HIV; HIV Protease Inhibitors; Humans; Interferon-alpha; Macrophage Colony-Stimulating Factor; Macrophages; Virus Replication; Zidovudine | 1994 |
Long-term treatment with zidovudine in patients with human immunodeficiency virus (HIV)-associated thrombocytopenia: modes of response and correlation with markers of HIV replication.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; CD4-Positive T-Lymphocytes; Female; HIV; Humans; Leukocyte Count; Male; Platelet Count; Thrombocytopenia; Virus Replication; Zidovudine | 1993 |
Measurement of HIV virus load and genotypic resistance by gene amplification in asymptomatic subjects treated with combination therapy.
Topics: CD4-Positive T-Lymphocytes; Codon; Didanosine; Drug Therapy, Combination; Gene Amplification; Genes, Viral; HIV; HIV Infections; Humans; Leukocyte Count; RNA, Viral; Zidovudine | 1993 |
Solid-state and solution conformations of the potent HIV inhibitor, 4'-azidothymidine.
Topics: Antiviral Agents; Crystallography, X-Ray; HIV; Magnetic Resonance Spectroscopy; Molecular Conformation; Stereoisomerism; Zidovudine | 1994 |
Prophylactic zalcitabine and interferon-alpha for a large-bore needlestick exposure to human immunodeficiency virus.
Topics: Adult; Didanosine; Drug Resistance, Microbial; Drug Therapy, Combination; Female; HIV; HIV Infections; Humans; Infectious Disease Transmission, Patient-to-Professional; Interferon alpha-2; Interferon-alpha; Needlestick Injuries; Recombinant Proteins; Zalcitabine; Zidovudine | 1994 |
[What is the future of antiviral therapy of HIV-infected patients? Reports of results of antiretroviral therapy studies at the IX. World Congress on AIDS in Berlin].
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Berlin; HIV; HIV Infections; Humans; Zidovudine | 1993 |
Comparative embryonic cytotoxicity of antiretroviral nucleosides.
Topics: Animals; Antiviral Agents; Culture Techniques; Didanosine; Embryo, Mammalian; HIV; Mice; Nucleosides; Stavudine; Zalcitabine; Zidovudine | 1994 |
3'-Azido-3'-deoxythymidine potently inhibits protein glycosylation. A novel mechanism for AZT cytotoxicity.
Topics: Animals; CHO Cells; Cricetinae; Cytidine Monophosphate N-Acetylneuraminic Acid; Dideoxynucleotides; Glycosylation; Golgi Apparatus; HIV; HIV Infections; Humans; Intracellular Membranes; Kinetics; Membrane Proteins; Nucleoside Diphosphate Sugars; Protein Processing, Post-Translational; Thymine Nucleotides; Uridine Diphosphate Galactose; Uridine Diphosphate N-Acetylglucosamine; Zidovudine | 1994 |
Cystamine potently suppresses in vitro HIV replication in acutely and chronically infected human cells.
Topics: Antiviral Agents; Cells, Cultured; Cystamine; DNA Replication; Dose-Response Relationship, Drug; HIV; HIV Core Protein p24; Humans; Lymphocytes; Macrophages; Proviruses; Viral Proteins; Virus Replication; Zidovudine | 1994 |
In vitro and in vivo disposition and metabolism of 3'-deoxy-2',3'-didehydrothymidine.
Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Biological Availability; Biotransformation; Chromatography, High Pressure Liquid; Feces; HIV; In Vitro Techniques; Injections, Intravenous; Injections, Subcutaneous; Liver; Macaca fascicularis; Macaca mulatta; Rats; Rats, Sprague-Dawley; Stavudine; Thymine; Zidovudine | 1993 |
Persistence of four related human immunodeficiency virus subtypes during the course of zidovudine therapy: relationship between virion RNA and proviral DNA.
Topics: Amino Acid Sequence; Consensus Sequence; DNA, Complementary; DNA, Viral; Genetic Variation; Glycosylation; HIV; HIV Infections; Humans; Molecular Sequence Data; Polymerase Chain Reaction; Protein Processing, Post-Translational; Proviruses; RNA, Viral; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Time Factors; Virion; Zidovudine | 1994 |
Smoothed nonparametric back-projection of AIDS incidence data with adjustment for therapy.
Topics: Acquired Immunodeficiency Syndrome; Australia; HIV; HIV Infections; Humans; Incidence; Mathematics; Models, Statistical; Zidovudine | 1993 |
'U' discovers transmission of AZT-resistant AIDS.
Topics: Acquired Immunodeficiency Syndrome; Drug Resistance; HIV; Humans; Zidovudine | 1993 |
AZT patent. Court favors drug 'concept' over proof.
Topics: Acquired Immunodeficiency Syndrome; Drug Industry; HIV; Humans; Patents as Topic; United States; Zidovudine | 1993 |
Cell-to-cell transmission of human immunodeficiency virus infection induces two distinct phases of viral RNA expression under separate regulatory control.
Topics: Cell Line; Gene Expression Regulation, Viral; HIV; HIV Infections; Humans; RNA, Viral; Time Factors; Transcription, Genetic; Zidovudine | 1993 |
Does zidovudine reduce tumour necrosis factor-alpha in HIV-positive patients?
Topics: HIV; HIV Infections; Humans; Tumor Necrosis Factor-alpha; Virus Replication; Zidovudine | 1993 |
A disappointing decade of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Africa; Antiviral Agents; Child; Forecasting; HIV; HIV Infections; Humans; Zidovudine | 1993 |
Study of human immunodeficiency virus resistance to 2'-3'-dideoxyinosine and zidovudine in sequential isolates from pediatric patients on long-term therapy.
Topics: Child; Child, Preschool; Dideoxyadenosine; Drug Resistance, Microbial; Female; HIV; HIV Seropositivity; Humans; Infant; Male; Zidovudine | 1993 |
A tale of two mutants.
Topics: Antitubercular Agents; Drug Resistance; HIV; HIV Infections; Humans; Mutation; Mycobacterium tuberculosis; Tuberculosis, Pulmonary; Zidovudine | 1993 |
Syringe attack by AIDS patient may be first documented.
Topics: Acquired Immunodeficiency Syndrome; Female; HIV; HIV Infections; Humans; Needlestick Injuries; Nursing Staff, Hospital; Occupational Exposure; Violence; Zidovudine | 1993 |
In vitro anti-human immunodeficiency virus (HIV) activities of transition state mimetic HIV protease inhibitors containing allophenylnorstatine.
Topics: Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; Drug Resistance, Microbial; Gene Products, gag; HIV; HIV Protease Inhibitors; HIV-1; HIV-2; Humans; Oligopeptides; Phenylbutyrates; Protein Precursors; Protein Processing, Post-Translational; Radioimmunoprecipitation Assay; Zidovudine | 1993 |
Identification of a novel human immunodeficiency virus strain cytopathic to megakaryocytic cells.
Topics: Antibodies, Monoclonal; CD4 Antigens; Cell Survival; Cytopathogenic Effect, Viral; HIV; HIV Envelope Protein gp120; Humans; Leukemia, Megakaryoblastic, Acute; Megakaryocytes; Polymerase Chain Reaction; Tumor Cells, Cultured; Virus Replication; Zidovudine | 1993 |
Response: arguments contradict the "foreign protein-zidovudine" hypothesis.
Topics: Acquired Immunodeficiency Syndrome; Factor VIII; Hemophilia A; HIV; HIV Seropositivity; Humans; Risk Factors; Zidovudine | 1996 |
From pseudocholinesterase to human immunodeficiency virus.
Topics: Animals; Antibodies; Apolipoproteins E; Biochemistry; Butyrylcholinesterase; Chloroquine; Drug Carriers; Endocytosis; Enzyme Activation; HIV; HIV Antibodies; HIV Envelope Protein gp120; HIV Infections; HIV Reverse Transcriptase; Humans; Immunoconjugates; Immunotherapy; Liposomes; Liver; Low Density Lipoprotein Receptor-Related Protein-1; Lysosomes; Mammals; Receptors, Lipoprotein; RNA-Directed DNA Polymerase; Zidovudine | 1995 |
Tumor necrosis factor-alpha in serum of macaques during SIVmac251 acute infection.
Topics: Acquired Immunodeficiency Syndrome; Animals; Antiviral Agents; Biomarkers; Disease Models, Animal; Female; HIV; Humans; Macaca fascicularis; Male; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Time Factors; Tumor Necrosis Factor-alpha; Viremia; Virus Replication; Zidovudine | 1995 |
SC-52151, a novel inhibitor of the human immunodeficiency virus protease.
Topics: Amino Acid Sequence; Animals; Antiviral Agents; Dogs; Drug Synergism; HIV; HIV Protease Inhibitors; Humans; Macaca mulatta; Molecular Sequence Data; Protein Binding; Rats; Rats, Sprague-Dawley; Urea; Zidovudine | 1995 |
Update: provisional Public Health Service recommendations for chemoprophylaxis after occupational exposure to HIV.
Topics: Antiviral Agents; Blood-Borne Pathogens; Chemoprevention; HIV; HIV Infections; Humans; Occupational Exposure; United States; United States Public Health Service; Zidovudine | 1996 |
In vivo drug screening applications of HIV-infected cells cultivated within hollow fibers in two physiologic compartments of mice.
Topics: Animals; Antiviral Agents; Cells, Cultured; Drug Evaluation, Preclinical; HIV; HIV Core Protein p24; Humans; Mice; Mice, SCID; RNA-Directed DNA Polymerase; Virus Cultivation; Virus Replication; Zalcitabine; Zidovudine | 1995 |
From the Centers for Disease Control and Prevention. Update: provisional public health service recommendations for chemoprophylaxis after occupational exposure to HIV.
Topics: Antiviral Agents; Blood-Borne Pathogens; Chemoprevention; HIV; HIV Infections; Humans; Occupational Exposure; United States; United States Public Health Service; Zidovudine | 1996 |
NMR study of dideoxynucleotides with anti-human immunodeficiency virus (HIV) activity.
Topics: Antiviral Agents; Dideoxynucleotides; HIV; Humans; Inosine Triphosphate; Magnetic Resonance Spectroscopy; Models, Theoretical; Molecular Conformation; Molecular Structure; Thymine Nucleotides; Zidovudine | 1996 |
[Zidovudine-resistant HIV strains in intravenous drug users and homosexual men in Amsterdam].
Topics: Cohort Studies; Drug Resistance; HIV; HIV Infections; Homosexuality; Humans; Male; Point Mutation; Substance Abuse, Intravenous; Zidovudine | 1996 |
[Action of drugs based on native DNA against RNA and DNA containing viruses].
Topics: Animals; Antiviral Agents; Cells, Cultured; Cytomegalovirus; Ganciclovir; HIV; Humans; Interferon Inducers; Mice; RNA, Double-Stranded; RNA, Fungal; Simplexvirus; Zidovudine | 1995 |
New guidelines set for occupational HIV exposure.
Topics: Accidents, Occupational; Antiviral Agents; Drug Therapy, Combination; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Infectious Disease Transmission, Patient-to-Professional; Lamivudine; Practice Guidelines as Topic; Pyridines; Reverse Transcriptase Inhibitors; Zalcitabine; Zidovudine | 1996 |
[Resistance and combined use of anti-HIV drugs].
Topics: Antiviral Agents; Drug Resistance, Microbial; Drug Therapy, Combination; HIV; HIV Infections; Humans; Mutation; Zalcitabine; Zidovudine | 1995 |
Selective protection of toxicity of 2',3'-dideoxypyrimidine nucleoside analogs by beta-D-uridine in human granulocyte-macrophage progenitor cells.
Topics: Antiviral Agents; Bone Marrow Cells; Cells, Cultured; Dideoxynucleosides; Granulocytes; Hematopoietic Stem Cells; HIV; Humans; Macrophages; Molecular Structure; Uridine; Zidovudine | 1996 |
Complete inhibition of viral breakthrough by combination of MKC-442 with AZT during a long-term culture of HIV-1 infected cells.
Topics: Acetamides; Acetophenones; Cell Line, Transformed; HIV; HIV Core Protein p24; HIV-1; Humans; Nevirapine; Pyridines; Reverse Transcriptase Inhibitors; Uracil; Zidovudine | 1996 |
Sulfated colominic acid: an antiviral agent that inhibits the human immunodeficiency virus type 1 in vitro.
Topics: Anti-HIV Agents; CD4 Antigens; Cell Line; Cell Line, Transformed; Drug Synergism; Flow Cytometry; Giant Cells; HIV; HIV Antigens; HIV Core Protein p24; HIV-1; Humans; Polysaccharides; RNA-Directed DNA Polymerase; Sulfates; T-Lymphocytes; Tumor Cells, Cultured; Zidovudine | 1996 |
Therapy of HIV infections: problems and prospects.
Topics: Anti-HIV Agents; Didanosine; Drug Resistance, Microbial; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Stavudine; Urban Health; Zalcitabine; Zidovudine | 1996 |
The effect of zidovudine on skeletal muscle mtDNA in HIV-1 infected patients with mild or no muscle dysfunction.
Topics: Adult; Base Sequence; DNA; Female; HIV; Humans; Male; Mitochondria; Molecular Sequence Data; Muscle, Skeletal; Neuromuscular Diseases; Zidovudine | 1996 |
Use of viral resistance patterns to antiretroviral drugs in optimising selection of drug combinations and sequences.
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Drug Resistance, Microbial; Drug Therapy, Combination; HIV; Humans; Protease Inhibitors; Reverse Transcriptase Inhibitors; Zidovudine | 1996 |
PHS updates guidelines on chemoprophylaxis after occupational HIV exposure.
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Female; Guidelines as Topic; Health Personnel; HIV; Humans; Male; Needlestick Injuries; Occupational Exposure; Zidovudine | 1996 |
[HIV: less resistance due to combined treatment].
Topics: Adult; Anti-HIV Agents; Computer Graphics; Drug Resistance, Microbial; Drug Therapy, Combination; HIV; HIV Infections; HIV Protease; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Time Factors; Zidovudine | 1996 |
[HIV: to administer protease inhibitors early].
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Drug Resistance, Microbial; Drug Therapy, Combination; HIV; HIV Protease Inhibitors; Humans; Lamivudine; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Time Factors; Zalcitabine; Zidovudine | 1996 |
[Nevirapine: a new principle of action against HIV].
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Child; Clinical Trials as Topic; Didanosine; Double-Blind Method; Drug Therapy, Combination; Female; HIV; HIV Infections; Humans; Infant, Newborn; Male; Nevirapine; Pregnancy; Pregnancy Complications, Infectious; Pyridines; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Time Factors; Zidovudine | 1996 |
[Prevalence of transmission of zidovudine-resistant viruses in Switzerland. l'Etude suisse de cohorte VIH].
Topics: Adolescent; Adult; Antiviral Agents; Base Sequence; DNA, Viral; Drug Resistance; Female; HIV; HIV Infections; HIV Reverse Transcriptase; Humans; Male; Middle Aged; Molecular Sequence Data; Polymerase Chain Reaction; Retrospective Studies; Zidovudine | 1996 |
Correspondence between the effect of zidovudine plus lamivudine on plasma HIV level/CD4 lymphocyte count and the incidence of clinical disease in infected individuals. North American Lamivudine HIV Working Group.
Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Double-Blind Method; Drug Therapy, Combination; HIV; HIV Infections; Humans; Lamivudine; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; RNA, Viral; Treatment Outcome; Viral Load; Zidovudine | 1997 |
Phenotypic variations and switches in HIV isolated from the blood and the gastrointestinal tissues of patients with HIV-1 infection. HIV/GI Research Study Group.
Topics: Biopsy; Didanosine; Digestive System; Female; Giant Cells; HIV; HIV Enteropathy; HIV Infections; Humans; Male; Mutation; Phenotype; Prospective Studies; Stavudine; Viral Load; Zidovudine | 1997 |
Low infant infection rate halts study of perinatal HIV transmission.
Topics: Anti-HIV Agents; Clinical Trials as Topic; Female; HIV; HIV Infections; Humans; Immunization, Passive; Infant, Newborn; Infectious Disease Transmission, Vertical; Pregnancy; Zidovudine | 1997 |
HIV dementia and apolipoprotein E.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Apolipoproteins E; Base Sequence; Electrophoresis, Agar Gel; Encephalitis, Viral; Female; Gene Amplification; Genotype; HIV; Humans; Male; Molecular Sequence Data; Polymerase Chain Reaction; Zidovudine | 1997 |
Human T cell lymphotropic virus type I does not increase human immunodeficiency virus viral load in vivo.
Topics: Adult; Anti-HIV Agents; Case-Control Studies; CD4 Lymphocyte Count; HIV; HIV Infections; HTLV-I Infections; Humans; Polymerase Chain Reaction; RNA, Viral; Viral Load; Zidovudine | 1997 |
A branched DNA signal amplification assay for quantification of nucleic acid targets below 100 molecules/ml.
Topics: Adenosine; Anti-HIV Agents; Cytidine; DNA; DNA, Viral; Drug Therapy, Combination; Guanosine; HIV; HIV Infections; Humans; Isoquinolines; Lamivudine; Nelfinavir; Nucleic Acid Hybridization; RNA, Viral; Sulfonic Acids; Zidovudine | 1997 |
Antiretroviral resistance and HIV vertical transmission.
Topics: Anti-HIV Agents; Drug Resistance, Microbial; Female; HIV; HIV Infections; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Pregnancy; Pregnancy Complications, Infectious; Zidovudine | 1997 |
CD8 T-cell response to antiretroviral therapy.
Topics: Anti-HIV Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lymphocyte Count; T-Lymphocytes, Cytotoxic; Zidovudine | 1997 |
Cure or control of HIV/AIDS?
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Didanosine; Drug Resistance, Microbial; Drug Therapy, Combination; HIV; HIV Infections; Humans; Indinavir; Lamivudine; Models, Biological; Nevirapine; Pyridines; Ritonavir; Saquinavir; Stavudine; Zalcitabine; Zidovudine | 1997 |
The existence of human immunodeficiency virus resistance to nucleoside-analog drugs has not been shown.
Topics: Anti-HIV Agents; Artifacts; Drug Resistance, Microbial; HIV; Humans; Microbial Sensitivity Tests; Models, Biological; Nucleosides; Zidovudine | 1997 |
[Once-daily administration of didanosine in combination with anti-retroviral zidovudine in previously untreated patients].
Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Didanosine; Drug Therapy, Combination; Female; HIV; HIV Infections; Humans; Male; Middle Aged; RNA, Viral; Zidovudine | 1997 |
Viral phenotype, antiretroviral resistance and clinical evolution in human immunodeficiency virus-infected children.
Topics: Adolescent; Anti-HIV Agents; Child; Child, Preschool; Drug Resistance; Female; HIV; HIV Infections; Humans; Infant; Male; Mutation; Phenotype; Prospective Studies; Zidovudine | 1997 |
Human immunodeficiency virus infection impairs hemopoiesis in long-term bone marrow cultures: nonreversal by nucleoside analogues.
Topics: Anti-HIV Agents; Antigens, CD34; Apoptosis; Bone Marrow Cells; Cell Death; Cells, Cultured; Didanosine; Hematopoiesis; Hematopoietic Stem Cells; HIV; HIV Core Protein p24; Humans; Stromal Cells; Zidovudine | 1997 |
Lack of antiretroviral effect of alpha-interferon in HIV-infected patients treated for chronic hepatitis C.
Topics: Adult; Drug Therapy, Combination; Female; Hepatitis C, Chronic; HIV; HIV Infections; Humans; Interferon Type I; Male; Middle Aged; Virus Replication; Zidovudine | 1997 |
Visceral leishmaniasis in patients infected with the human immunodeficiency virus.
Topics: AIDS-Related Opportunistic Infections; Allopurinol; Amebicides; Amphotericin B; Analysis of Variance; Anti-HIV Agents; Antimetabolites; Antimony; Antiprotozoal Agents; Blood; Bone Marrow; CD4-Positive T-Lymphocytes; Cerebrospinal Fluid; Didanosine; Digestive System; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatic Encephalopathy; HIV; Humans; Intestinal Mucosa; Leishmaniasis, Visceral; Lymphocyte Count; Male; Myocarditis; Neutrophils; Pancreatitis; Pentamidine; Renal Insufficiency; Spain; Zidovudine | 1997 |
[Zidovudine-resistant HIV strains in untreated intravenous drug users and homosexual men in Amsterdam infected in 1996].
Topics: Anti-HIV Agents; Drug Resistance, Microbial; HIV; HIV Infections; Homosexuality, Male; Humans; Male; Substance Abuse, Intravenous; Zidovudine | 1997 |
Asymmetric synthesis of 4'-alpha-alkylcarbovir derivatives.
Topics: Alkylation; Anti-HIV Agents; Dideoxynucleosides; HIV; Indicators and Reagents; Molecular Structure; Zidovudine | 1997 |
Determinants of progression to AIDS in HIV-infected individuals: an update from the Italian Seroconversion Study.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Aged; Anti-HIV Agents; Cohort Studies; Disease Progression; Female; HIV; Humans; Italy; Male; Middle Aged; Zidovudine | 1998 |
Inhibition by 3'-azido-3'-deoxythymidine (AZT) of Trypanosoma cruzi growth in mammalian cells and a possible mechanism of action.
Topics: Animals; Antiprotozoal Agents; Dideoxynucleosides; HeLa Cells; HIV; Humans; Mammals; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Trypanosoma cruzi; Zidovudine | 1998 |
The expression of the essential nuclear splicing factor SC35 is altered by human immunodeficiency virus infection.
Topics: Anti-HIV Agents; Blotting, Northern; Cell Nucleus; DNA, Complementary; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Gene Expression; HIV; Humans; Microscopy, Confocal; Nuclear Proteins; Ribonucleoproteins; RNA Splicing; RNA, Messenger; Serine-Arginine Splicing Factors; T-Lymphocytes; Time Factors; Tumor Cells, Cultured; Virus Replication; Zidovudine | 1998 |
Antiretroviral triple therapy decreases HIV viral load but does not alter hepatitis C virus (HCV) serum levels in HIV-HCV-co-infected haemophiliacs.
Topics: AIDS-Related Opportunistic Infections; Anti-HIV Agents; Cohort Studies; Drug Therapy, Combination; Hemophilia A; Hepacivirus; Hepatitis C; HIV; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Reverse Transcriptase Inhibitors; RNA, Viral; Saquinavir; Stavudine; Treatment Outcome; Viral Load; Zidovudine | 1998 |
A mixed model for repeated dilution assays.
Topics: Anti-HIV Agents; Didanosine; Drug Therapy, Combination; HIV; HIV Infections; Humans; Models, Statistical; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Reproducibility of Results; Viral Load; Zalcitabine; Zidovudine | 1998 |
[Resistance of human immunodeficiency virus (HIV) to zidovudine. Genotypic analysis in strains isolated from Chilean patients].
Topics: Anti-HIV Agents; Chile; Codon; Drug Resistance; Follow-Up Studies; Genotype; HIV; HIV Infections; Humans; Mutation; Prospective Studies; Zidovudine | 1998 |
Long-term suppression of HIV replication in patients with sustained benefit on zidovudine monotherapy.
Topics: Anti-HIV Agents; Follow-Up Studies; HIV; HIV Infections; Humans; Proviruses; RNA, Viral; Virus Replication; Zidovudine | 1998 |
A pharmacokinetic-pharmacodynamic model of chemotherapy of human immunodeficiency virus infection that relates development of drug resistance to treatment intensity.
Topics: Anti-HIV Agents; CD4-CD8 Ratio; Dose-Response Relationship, Drug; Drug Resistance, Microbial; HIV; HIV Infections; Humans; Models, Theoretical; Nelfinavir; Zidovudine | 1997 |
Chemoprophylaxis after occupational exposure to human immunodeficiency virus in forensic autopsy.
Topics: Anti-HIV Agents; Drug Therapy, Combination; Forensic Medicine; HIV; HIV Infections; Humans; Indinavir; Lamivudine; Occupational Exposure; Zidovudine | 1998 |
[AIDS drug in the correct form].
Topics: Anti-HIV Agents; HIV; HIV Infections; Humans; Molecular Conformation; National Institutes of Health (U.S.); Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; United States; Zidovudine | 1998 |
[New trends in HIV].
Topics: Anti-HIV Agents; Drug Resistance, Microbial; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lipodystrophy; Reverse Transcriptase Inhibitors; Zidovudine | 1998 |
Further characterization of HIV RNA synthesis early after cell-to-cell transmission infection.
Topics: Aphidicolin; Dactinomycin; DNA, Viral; HIV; Humans; RNA, Viral; Zidovudine | 1998 |
Dynamics of provirus load and lymphocyte subsets after interleukin 2 treatment in HIV-infected patients.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-HIV Agents; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Didanosine; Female; HIV; Humans; Interleukin-2; Male; Polymerase Chain Reaction; Proviruses; Recombinant Proteins; T-Lymphocyte Subsets; Viral Load; Zidovudine | 1999 |
Synthesis of dual function (5R,6R)- and (5S,6S)-5-bromo-6-methoxy-5,6-dihydro-AZT-5'-(para-bromophenyl methoxyalaninyl phosphate) as novel spermicidal and anti-HIV agents.
Topics: Anti-HIV Agents; Contraceptive Devices, Female; Dideoxynucleotides; Female; HIV; HIV Infections; Humans; Male; Nonoxynol; Organophosphorus Compounds; Spermatocidal Agents; Spermatozoa; Virus Replication; Zidovudine | 1999 |
Antiretroviral drugs: new agents, new combinations line up against HIV.
Topics: Antiviral Agents; Australia; Didanosine; Drug Therapy, Combination; Europe; HIV; HIV Infections; Humans; Lamivudine; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Ritonavir; Thiazoles; United States; Valine; Zalcitabine; Zidovudine | 1996 |
Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine.
Topics: Amino Acids; Animals; Anti-HIV Agents; Biotransformation; Dideoxynucleotides; Drug Design; Esterases; Esters; HIV; Humans; Liver; Male; Mice; Nucleosides; Prodrugs; Rats; Rats, Wistar; Reverse Transcriptase Inhibitors; Stavudine; Thymine Nucleotides; Tumor Cells, Cultured; Zidovudine | 1999 |
Use of recombinant viruses to assess the pattern of early human immunodeficiency virus breakthrough infection in the presence of stavudine.
Topics: Animals; Anti-HIV Agents; COS Cells; Defective Viruses; Floxuridine; HeLa Cells; HIV; Humans; Jurkat Cells; Leukemia Virus, Murine; Recombination, Genetic; Stavudine; Zidovudine | 1999 |
Drug-antibody conjugates with anti-HIV activity.
Topics: Amino Acid Sequence; Anti-HIV Agents; Glycoproteins; HIV; HIV Antibodies; HIV Envelope Protein gp120; Humans; Immunoconjugates; Immunodeficiency Virus, Feline; Leukocytes, Mononuclear; Microbial Sensitivity Tests; Molecular Sequence Data; Reverse Transcriptase Inhibitors; Tumor Cells, Cultured; Virus Replication; Zidovudine | 1999 |
Drug susceptibility in HIV infection after viral rebound in patients receiving indinavir-containing regimens.
Topics: Anti-HIV Agents; Drug Resistance, Microbial; Drug Therapy, Combination; Genotype; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Phenotype; RNA, Viral; Treatment Failure; Viral Load; Zidovudine | 2000 |
[HIV-1 (human immunodeficiency virus type 1) mutant strain associated with zidovudine resistance detected from a Japanese patient with primary HIV-1 infection].
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Drug Resistance, Microbial; HIV; Humans; Japan; Mutation; Zidovudine | 2000 |
Emergence of zidovudine resistance in HIV-infected patients receiving stavudine.
Topics: Adult; Anti-HIV Agents; Drug Resistance, Microbial; Drug Therapy, Combination; Female; HIV; HIV Infections; Humans; Male; Stavudine; Zidovudine | 2000 |
Cutaneous side effects induced by indinavir.
Topics: Adult; Alopecia; Didanosine; Drug Eruptions; Drug Therapy, Combination; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Lipodystrophy; Male; Middle Aged; Pruritus; Pyoderma Gangrenosum; Retrospective Studies; Reverse Transcriptase Inhibitors; RNA, Viral; Scalp Dermatoses; Skin; Stavudine; Zalcitabine; Zidovudine | 2000 |
Failure to develop HIV infection after receipt of HIV-contaminated blood and postexposure prophylaxis.
Topics: Adolescent; Anti-HIV Agents; Drug Administration Schedule; Drug Therapy, Combination; HIV; HIV Infections; Humans; Indinavir; Lamivudine; Nelfinavir; Transfusion Reaction; Zidovudine | 2000 |
Mbeki gives AIDS scientists the cold shoulder.
Topics: Acquired Immunodeficiency Syndrome; Adult; Breast Feeding; Enzyme-Linked Immunosorbent Assay; Female; Government; HIV; Humans; Infectious Disease Transmission, Vertical; Male; Middle Aged; Nevirapine; Poverty; Predictive Value of Tests; Pregnancy; Pregnancy Complications, Infectious; South Africa; Zidovudine | 2000 |
Correlation between human immunodeficiency virus genotypic resistance and virologic response in patients receiving nelfinavir monotherapy or nelfinavir with lamivudine and zidovudine.
Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Clinical Trials as Topic; Drug Resistance, Microbial; Drug Therapy, Combination; Genotype; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Mutation; Nelfinavir; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; RNA, Viral; Zidovudine | 2000 |
LuSIV cells: a reporter cell line for the detection and quantitation of a single cycle of HIV and SIV replication.
Topics: Cell Line; Cells, Cultured; Genes, Reporter; Genes, tat; HIV; Humans; Luciferases; Plasmids; Simian Immunodeficiency Virus; Transcriptional Activation; Transfection; Virus Replication; Zidovudine | 2000 |
Primary macrophages infected by human immunodeficiency virus trigger CD95-mediated apoptosis of uninfected astrocytes.
Topics: Anti-HIV Agents; Apoptosis; Astrocytes; Cell Communication; Cells, Cultured; Fas Ligand Protein; fas Receptor; Gene Products, tat; HIV; HIV Envelope Protein gp120; Homeostasis; Humans; Macrophages; Male; Membrane Glycoproteins; Middle Aged; Necrosis; tat Gene Products, Human Immunodeficiency Virus; Zidovudine | 2000 |
PMS-601, a new platelet-activating factor receptor antagonist that inhibits human immunodeficiency virus replication and potentiates zidovudine activity in macrophages.
Topics: Anti-HIV Agents; Drug Synergism; HIV; Humans; Macrophages; Piperazines; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Virus Replication; Zidovudine | 2000 |
[Genotypic resistance to antiretroviral drugs in patients with therapeutic failure to highly active antiretroviral therapy].
Topics: Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Resistance, Microbial; Endopeptidases; Female; Genotype; HIV; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Male; Middle Aged; Mutation; Nevirapine; Protease Inhibitors; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Treatment Failure; Zidovudine | 2000 |
[Prevalence of primary mutations in human immunodeficiency virus with resistance to nucleoside analogues in previously untreated patients from Andalusia. Andalusian Group for the Study of Infectious diseases (GAEI)].
Topics: Adult; Anti-HIV Agents; CD4 Antigens; Codon; Data Interpretation, Statistical; DNA, Viral; Drug Resistance, Microbial; Female; Genotype; HIV; HIV Infections; Humans; Lamivudine; Male; Mutation; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; RNA, Viral; Spain; Viral Load; Zidovudine | 2000 |
[Resistance to antiretroviral drugs: a clinical, public health and health policy debate].
Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-HIV Agents; Child; Clinical Trials as Topic; Drug Resistance, Microbial; Female; Genotype; Health Policy; HIV; HIV Infections; Humans; Male; Pregnancy; Public Health; Research; Reverse Transcriptase Inhibitors; Spain; Viral Load; Zidovudine | 2000 |
Zidovudine phosphorylation determined sequentially over 12 months in human immunodeficiency virus-infected patients with or without previous exposure to antiretroviral agents.
Topics: Adult; Anti-HIV Agents; Dideoxynucleotides; Female; HIV; HIV Infections; Humans; Longitudinal Studies; Male; Middle Aged; Phosphorylation; Thymine Nucleotides; Zidovudine | 2001 |
Low-dose, sublingual AZT-monophosphate therapy for HIV+ patients?
Topics: Administration, Sublingual; Anti-HIV Agents; Dideoxynucleotides; HIV; HIV Infections; HIV Seropositivity; Humans; Models, Biological; Thymidine Kinase; Thymine Nucleotides; Virus Replication; Zidovudine | 2001 |
ZDV resistance AIDS predictor.
Topics: Acquired Immunodeficiency Syndrome; Drug Resistance; HIV; Humans; Zidovudine | 1994 |
New antiretroviral strategies: interview with Marcus Conant, M.D. Interview by John S. James.
Topics: Antiviral Agents; CD4 Lymphocyte Count; DNA, Viral; Drug Therapy, Combination; HIV; HIV Infections; Humans; Isoquinolines; Lamivudine; Peripheral Nervous System Diseases; Protease Inhibitors; Quinolines; Saquinavir; Stavudine; Zalcitabine; Zidovudine | 1995 |
A new nucleoside analogue.
Topics: Acquired Immunodeficiency Syndrome; AIDS Dementia Complex; CD4 Lymphocyte Count; Clinical Trials as Topic; Drug Interactions; Drug Therapy, Combination; Drugs, Investigational; HIV; Humans; Nucleosides; Phenotype; RNA-Directed DNA Polymerase; Zidovudine | 1995 |
Saquinavir thwarts resistance.
Topics: Acquired Immunodeficiency Syndrome; Clinical Trials as Topic; Drug Resistance, Microbial; Drug Therapy, Combination; HIV; HIV Protease Inhibitors; Humans; Isoquinolines; Quinolines; Saquinavir; Zidovudine | 1995 |
A Lisbon traviata. Are clinicians ready to sing addio to monotherapy and libiamo to combinations?
Topics: Antiviral Agents; CD4 Lymphocyte Count; Clinical Trials as Topic; Drug Resistance, Microbial; Drug Synergism; Drug Therapy, Combination; HIV; HIV Infections; Humans; Hydroxyurea; Indinavir; Interleukin-2; Lamivudine; Mutation; Pyridines; RNA, Viral; Zalcitabine; Zidovudine | 1995 |
Roaches of inner space.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Drug Resistance, Microbial; Drug Therapy, Combination; HIV; HIV Infections; Lamivudine; Mutation; T-Lymphocytes, Cytotoxic; Virulence; Virus Replication; Zalcitabine; Zidovudine | 1995 |
Conference looks at HIV drug resistance.
Topics: Antiviral Agents; Carbamates; CD4 Lymphocyte Count; Drug Resistance, Microbial; Furans; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Isoquinolines; Lamivudine; Pyridines; Quinolines; Ritonavir; Saquinavir; Sulfonamides; Thiazoles; Valine; Viremia; Zalcitabine; Zidovudine | 1995 |
Mothers shown to transmit resistant strains to babies.
Topics: Antiviral Agents; HIV; HIV Infections; Infant, Newborn; Infectious Disease Transmission, Vertical; Mothers; Pregnancy; Pregnancy Complications, Infectious; Viremia; Zidovudine | 1995 |
Closing the circle on HIV--or not.
Topics: Antiviral Agents; Biomarkers; CD4 Lymphocyte Count; Clinical Trials as Topic; Didanosine; Drug Resistance, Microbial; Drug Therapy, Combination; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Interleukin-2; Nelfinavir; Prognosis; RNA, Viral; Zalcitabine; Zidovudine | 1995 |
To treat or not to treat--approaches to antiretroviral therapy. Interview by Anthony J. Japour.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; CD4 Lymphocyte Count; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Didanosine; Drug Therapy, Combination; HIV; Humans; Lamivudine; Practice Patterns, Physicians'; RNA, Viral; Zalcitabine; Zidovudine | 1996 |
Viral load linked to risk of transmission.
Topics: Female; HIV; HIV Infections; Humans; Infant; Infectious Disease Transmission, Vertical; Pregnancy; Pregnancy Complications, Infectious; Reverse Transcriptase Inhibitors; Risk Factors; RNA, Viral; Zidovudine | 1996 |
Nipping HIV in the bud.
Topics: Antiviral Agents; CD4 Lymphocyte Count; Didanosine; DNA, Viral; Drug Resistance, Microbial; Drug Therapy, Combination; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Isoquinolines; Lamivudine; Pyridines; Quinolines; Ritonavir; Saquinavir; Stavudine; Thiazoles; Valine; Virus Replication; Zalcitabine; Zidovudine | 1996 |
Nevirapine: new drug, new class, new questions.
Topics: Adult; Antiviral Agents; CD4 Lymphocyte Count; Child; Didanosine; Drug Approval; Drug Therapy, Combination; HIV; HIV Infections; Humans; Nevirapine; Pyridines; Reverse Transcriptase Inhibitors; United States; United States Food and Drug Administration; Zidovudine | 1996 |
Outdated yet out-of-reach: AIDS society treatment guidelines at the International Conference.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Antiviral Agents; CD4 Lymphocyte Count; Decision Making; Didanosine; Drug Therapy, Combination; HIV; HIV Infections; Humans; Lamivudine; Practice Guidelines as Topic; Zalcitabine; Zidovudine | 1996 |
Update on antivirals.
Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Drug Therapy, Combination; HIV; HIV Protease Inhibitors; Humans; Lamivudine; Reverse Transcriptase Inhibitors; RNA, Viral; Zidovudine | 1996 |
NIAID researchers present new findings at retrovirus meeting. National Institute of Allergy and Infectious Diseases.
Topics: Anti-HIV Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Chemokines; Clinical Trials as Topic; Clone Cells; Dendritic Cells; Didanosine; Disease Progression; Drug Therapy, Combination; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Interleukin-10; Killer Cells, Natural; Lamivudine; Male; Nevirapine; Pyridines; Receptors, Cytokine; Reverse Transcriptase Inhibitors; Ritonavir; Virus Replication; Zalcitabine; Zidovudine | 1997 |
New recommendations on health care worker exposure to HIV.
Topics: Anti-HIV Agents; Disease Transmission, Infectious; Drug Therapy, Combination; Guidelines as Topic; Health Personnel; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Occupational Exposure; Risk Factors; Viral Load; Zidovudine | 1996 |
Scientific basis for PEP rests in animal trials.
Topics: Adenine; Animals; Anti-HIV Agents; Centers for Disease Control and Prevention, U.S.; Health Personnel; HIV; HIV Infections; Humans; Macaca; Nevirapine; Occupational Diseases; Organophosphonates; Organophosphorus Compounds; Pan troglodytes; Pyridines; Reverse Transcriptase Inhibitors; Simian Immunodeficiency Virus; Tenofovir; United States; Zidovudine | 1997 |
Hydroxyurea, a potential new anti-HIV agent.
Topics: Didanosine; DNA Replication; Drug Therapy, Combination; HIV; HIV Infections; Humans; Hydroxyurea; Leukocytes, Mononuclear; Virus Replication; Zalcitabine; Zidovudine | 1995 |
AIDS--the first 20 years.
Topics: Acquired Immunodeficiency Syndrome; AIDS Vaccines; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Blood Banks; Female; Financing, Government; Global Health; History, 20th Century; History, 21st Century; HIV; HIV Seroprevalence; Humans; Male; Research Support as Topic; United States; Zidovudine | 2001 |
Prevalence and predictive value of intermittent viremia with combination hiv therapy.
Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Resistance, Microbial; HIV; HIV Infections; Humans; Indinavir; Lamivudine; Predictive Value of Tests; Prevalence; Proportional Hazards Models; Retrospective Studies; RNA, Viral; Viral Load; Viremia; Virus Replication; Zidovudine | 2001 |
Inhibition of HIV replication by A77 1726, the active metabolite of leflunomide, in combination with pyrimidine nucleoside reverse transcriptase inhibitors.
Topics: Aniline Compounds; Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal; Crotonates; HIV; HIV Core Protein p24; HIV Seronegativity; Humans; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocytes; Nitriles; Reverse Transcriptase Inhibitors; Toluidines; Virus Replication; Zidovudine | 2001 |
HIV pathogenesis and activation of CD4 cells.
Topics: Anti-HIV Agents; CD4-Positive T-Lymphocytes; Genes, nef; Genes, tat; HIV; Humans; Interleukin-2; Lymphocyte Activation; Reverse Transcriptase Inhibitors; Up-Regulation; Virus Replication; Zidovudine | 2001 |
Zidovudine (Retrovir).
Topics: Drug Resistance, Microbial; HIV; HIV Infections; Humans; Practice Guidelines as Topic; Reverse Transcriptase Inhibitors; Zidovudine | 2000 |
Experience with routine voluntary perinatal human immunodeficiency virus testing in an inner city hospital.
Topics: Anti-HIV Agents; Decision Making; Female; HIV; HIV Infections; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Logistic Models; Mass Screening; Pregnancy; Prenatal Care; Risk Factors; Zidovudine | 2001 |
Prediction of abacavir resistance from genotypic data: impact of zidovudine and lamivudine resistance in vitro and in vivo.
Topics: Algorithms; Anti-HIV Agents; Dideoxynucleosides; Drug Resistance, Microbial; Gene Frequency; Genotype; HIV; Humans; Lamivudine; Microbial Sensitivity Tests; Zidovudine | 2002 |
Estimation of the timing of perinatal transmission of HIV.
Topics: Anti-HIV Agents; Biometry; Clinical Trials as Topic; Female; HIV; HIV Infections; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Linear Models; Models, Statistical; Polymerase Chain Reaction; Pregnancy; Pregnancy Complications, Infectious; Sensitivity and Specificity; Time Factors; Zidovudine | 2001 |
An APE that proofreads.
Topics: Anti-HIV Agents; Carbon-Oxygen Lyases; DNA; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA, Viral; Escherichia coli; HIV; Humans; Stavudine; Substrate Specificity; Zidovudine | 2002 |
Transmission of drug-resistant HIV after an occupational exposure despite postexposure prophylaxis with a combination drug regimen.
Topics: Adult; Anti-HIV Agents; Health Personnel; HIV; HIV Infections; Humans; Infectious Disease Transmission, Patient-to-Professional; Lamivudine; Needlestick Injuries; Occupational Exposure; Treatment Failure; Zidovudine | 2002 |
Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine.
Topics: Antiviral Agents; Emtricitabine; HIV; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Lamivudine; Reverse Transcriptase Inhibitors; Stereoisomerism; Zalcitabine; Zidovudine | 1992 |
Pharmacokinetic evaluation of drug interactions with anti-human immunotrophic virus (HIV) Drugs. III. 2',3'-Dideoxycytidine (ddC) and zidovudine in monkeys.
Topics: Animals; Antiviral Agents; Drug Interactions; HIV; Macaca fascicularis; Male; Zalcitabine; Zidovudine | 1992 |
The defect seen in the phosphatidylinositol hydrolysis pathway in HIV-infected lymphocytes and lymphoblastoid cells is due to inhibition of the inositol 1,4,5-trisphosphate 1,3,4,5-tetrakisphosphate 5-phosphomonoesterase.
Topics: Adenosine Triphosphate; Calcium; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Down-Regulation; HIV; HIV Envelope Protein gp120; Humans; Hydrolysis; Inositol Polyphosphate 5-Phosphatases; Lymphocytes; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Signal Transduction; Zidovudine | 1992 |
Different pattern of activity of inhibitors of the human immunodeficiency virus in lymphocytes and monocyte/macrophages.
Topics: Adenine; Antibodies, Viral; Antiviral Agents; Benzodiazepines; CD4 Antigens; Cytokines; Didanosine; Doxorubicin; Drug Interactions; HIV; HIV Infections; Humans; Imidazoles; Leukocytes, Mononuclear; Lymphocytes; Macrophages; Monocytes; Organ Specificity; Organophosphonates; Zalcitabine; Zidovudine | 1992 |
Inhibition of HIV infection of resting peripheral blood lymphocytes by nucleosides.
Topics: Base Sequence; Cells, Cultured; Didanosine; DNA, Viral; HIV; Humans; Lymphocyte Activation; Molecular Sequence Data; Polymerase Chain Reaction; Proviruses; T-Lymphocytes; Virus Replication; Zalcitabine; Zidovudine | 1992 |
Anti-human immunodeficiency virus (HIV) agents are also potent and selective inhibitors of feline immunodeficiency virus (FIV)-induced cytopathic effect: development of a new method for screening of anti-FIV substances in vitro.
Topics: Animals; Anthracyclines; Antibiotics, Antineoplastic; Antiviral Agents; Cats; Cell Fusion; Cells, Cultured; Cytopathogenic Effect, Viral; Dextran Sulfate; Didanosine; Drug Evaluation, Preclinical; Heparin; HIV; Humans; Immunodeficiency Virus, Feline; Virus Replication; Zidovudine | 1992 |
HIV as target for zidovudine.
Topics: Acquired Immunodeficiency Syndrome; HIV; Humans; Zidovudine | 1992 |
HIV and AIDS.
Topics: Acquired Immunodeficiency Syndrome; CD4-Positive T-Lymphocytes; Female; HIV; HIV Infections; Humans; Male; Research; Viral Vaccines; Zidovudine | 1992 |
[Another AIDS drug. Azidothymidine--dideoxycytidine].
Topics: Acquired Immunodeficiency Syndrome; CD4-Positive T-Lymphocytes; HIV; Humans; Leukocyte Count; Virus Replication; Zalcitabine; Zidovudine | 1992 |
Development of resistance to zidovudine in HIV strains isolated from CD4+ lymphocytes and plasma during therapy.
Topics: Acquired Immunodeficiency Syndrome; CD4-Positive T-Lymphocytes; Drug Resistance, Microbial; HIV; Humans; Zidovudine | 1992 |
Ordered appearance of zidovudine resistance mutations during treatment of 18 human immunodeficiency virus-positive subjects.
Topics: Acquired Immunodeficiency Syndrome; Codon; Cohort Studies; Drug Resistance, Microbial; Genotype; HeLa Cells; HIV; HIV Infections; Homosexuality; Humans; Male; Mutation; Polymerase Chain Reaction; RNA-Directed DNA Polymerase; Time Factors; Viral Plaque Assay; Zidovudine | 1992 |
Selective action of 2',3'-didehydro-2',3'-dideoxythymidine triphosphate on human immunodeficiency virus reverse transcriptase and human DNA polymerases.
Topics: Antiviral Agents; Base Sequence; DNA; DNA-Directed DNA Polymerase; HIV; Humans; Kinetics; Molecular Sequence Data; Nucleic Acid Synthesis Inhibitors; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Substrate Specificity; Thymine Nucleotides; Zidovudine | 1992 |
Human immunodeficiency virus reverse transcriptase: steady-state and pre-steady-state kinetics of nucleotide incorporation.
Topics: Antiviral Agents; Base Sequence; Binding, Competitive; Dideoxynucleotides; HIV; Molecular Sequence Data; Oligonucleotide Probes; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Templates, Genetic; Thionucleotides; Thymine Nucleotides; Zidovudine | 1992 |
Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3'-azido-3'-deoxythymidine.
Topics: Antiviral Agents; Cell Line; Drug Resistance, Microbial; HIV; Humans; Kinetics; Polynucleotides; Recombinant Proteins; Reverse Transcriptase Inhibitors; Ribonuclease H; RNA-Directed DNA Polymerase; Species Specificity; Substrate Specificity; Zidovudine | 1992 |
Effects of bone marrow stimulatory cytokines on human immunodeficiency virus replication and the antiviral activity of dideoxynucleosides in cultures of monocyte/macrophages.
Topics: Antiviral Agents; Bone Marrow; Cells, Cultured; Cytokines; Didanosine; Dideoxynucleosides; Erythropoietin; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; HIV; Humans; Macrophage Colony-Stimulating Factor; Macrophages; Monocytes; Virus Replication; Zalcitabine; Zidovudine | 1992 |
Gastrointestinal tissue cultures for HIV in HIV-infected/AIDS patients. The University of Calgary Gastrointestinal/HIV Study Group.
Topics: Acquired Immunodeficiency Syndrome; Adult; Biopsy; Bisexuality; Digestive System; Duodenum; Esophagus; HIV; HIV Infections; Homosexuality; Humans; Male; Rectum; Stomach; Zidovudine | 1992 |
Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA.
Topics: Antiviral Agents; Base Sequence; Deoxycytosine Nucleotides; Dideoxynucleotides; DNA; DNA Polymerase I; DNA Polymerase II; HIV; Humans; Kinetics; Molecular Sequence Data; Terminator Regions, Genetic; Thymine Nucleotides; Zidovudine | 1992 |
Incidence of zidovudine-resistant human immunodeficiency virus isolated from patients before, during, and after therapy.
Topics: CD4 Antigens; Drug Resistance, Microbial; Female; Hemophilia A; HIV; HIV Antigens; HIV Infections; Homosexuality; Humans; Male; Substance Abuse, Intravenous; T-Lymphocyte Subsets; Virus Replication; Zidovudine | 1992 |
Summary of the Working Group on Perinatal Intervention.
Topics: Animals; Clinical Trials as Topic; Female; Fetal Diseases; HIV; HIV Infections; Humans; Immunization, Passive; Immunoglobulins, Intravenous; Infant; Infant, Newborn; Pregnancy; Pregnancy Complications, Infectious; Vaccination; Zidovudine | 1992 |
Quantitative RNA and DNA gene amplification can rapidly monitor HIV infection and antiviral activity in cell cultures.
Topics: Cells, Cultured; DNA, Viral; Genes, gag; HIV; HIV Core Protein p24; HIV Infections; HIV Seropositivity; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; RNA, Viral; Virus Replication; Zidovudine | 1992 |
A modeled time-varying density function for the incubation period of AIDS.
Topics: Acquired Immunodeficiency Syndrome; HIV; HIV Infections; Humans; Mathematics; Proportional Hazards Models; Time Factors; Zidovudine | 1992 |
Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidine.
Topics: Animals; Antiviral Agents; Cell Membrane Permeability; Cells, Cultured; Chromatography, High Pressure Liquid; Dideoxynucleosides; Female; HIV; Humans; Macaca fascicularis; Male; Tritium; Zidovudine | 1992 |
HIV detection in culture of peripheral blood mononuclear cells: a relevant in vitro correlate of the antiviral effect of ZDV in vivo.
Topics: Cells, Cultured; Female; HIV; HIV Seropositivity; Humans; Leukocytes, Mononuclear; Male; Virus Replication; Zidovudine | 1992 |
The effect of combinations of ampligen and zidovudine or dideoxyinosine against human immunodeficiency viruses in vitro.
Topics: Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; Didanosine; Drug Synergism; HeLa Cells; HIV; Humans; Poly I-C; Poly U; Zidovudine | 1992 |
Synthesis and anti-HIV activity of some novel lactyl and glycolyl phosphate derivatives.
Topics: Antiviral Agents; HIV; Organophosphorus Compounds; Zidovudine | 1992 |
Rage and confusion hide role of HIV.
Topics: Acquired Immunodeficiency Syndrome; Complementary Therapies; HIV; HIV Infections; Humans; Zidovudine | 1992 |
Synergistic antiviral effect in vitro of azidothymidine and amphotericin B methyl ester in combination on HIV infection.
Topics: Acquired Immunodeficiency Syndrome; Amphotericin B; Antifungal Agents; Cells, Cultured; Drug Synergism; Drug Therapy, Combination; HIV; HIV Infections; Humans; Zidovudine | 1992 |
Lipid conjugates of antiretroviral agents: release of antiretroviral nucleoside monophosphates by a nucleoside diphosphate diglyceride hydrolase activity from rat liver mitochondria.
Topics: Animals; Antiviral Agents; Cardiolipins; Diglycerides; HIV; Hydrolysis; Lipid Metabolism; Mitochondria, Liver; Phosphorylation; Pyrophosphatases; Rats; Thymine Nucleotides; Zidovudine | 1991 |
Markers for HIV-disease progression in untreated patients and patients receiving AZT: evaluation of viral activity, AZT resistance, serum cholesterol, beta 2-microglobulin, CD4+ cell counts, and HIV antigen.
Topics: beta 2-Microglobulin; CD4-Positive T-Lymphocytes; Cells, Cultured; Cholesterol, HDL; Drug Resistance, Microbial; Evaluation Studies as Topic; HIV; HIV Antigens; HIV Infections; Humans; Leukocyte Count; Macrophages; Monocytes; Time Factors; Zidovudine | 1991 |
Carbovir: the (-) enantiomer is a potent and selective antiviral agent against human immunodeficiency virus in vitro.
Topics: CD4-Positive T-Lymphocytes; Cell Line; Cell Survival; Dideoxynucleosides; Giant Cells; HIV; Humans; Viral Core Proteins; Virus Replication; Zalcitabine; Zidovudine | 1991 |
Reduction in plasma human immunodeficiency virus ribonucleic acid after dideoxynucleoside therapy as determined by the polymerase chain reaction.
Topics: CD4-Positive T-Lymphocytes; HIV; HIV Seropositivity; Humans; Leukocyte Count; Polymerase Chain Reaction; RNA, Viral; Zidovudine | 1991 |
Anti-HIV agents. I: Synthesis and in vitro anti-HIV evaluation of novel 1H,3H-thiazolo[3,4-a]benzimidazoles.
Topics: Antiviral Agents; Benzimidazoles; CD4-Positive T-Lymphocytes; Cell Line; Cytopathogenic Effect, Viral; HIV; Humans; Thiazoles; Zalcitabine; Zidovudine | 1991 |
Pharmacokinetics of anti-HIV nucleosides in microswine.
Topics: Animals; Antiviral Agents; Chromatography, High Pressure Liquid; Didanosine; Half-Life; HIV; Male; Nucleosides; Swine; Swine, Miniature; Zalcitabine; Zidovudine | 1991 |
Mechanism of HIV reverse transcriptase: enzyme-primer interaction as revealed through studies of a dNTP analogue, 3'-azido-dTTP.
Topics: Antiviral Agents; Bacteriophages; Chemical Phenomena; Chemistry; Dideoxynucleotides; DNA; DNA-Directed DNA Polymerase; HIV; Kinetics; Models, Molecular; RNA-Directed DNA Polymerase; Templates, Genetic; Thymine Nucleotides; Zidovudine | 1990 |
Selective action of 3'-azido-3'-deoxythymidine 5'-triphosphate on viral reverse transcriptases and human DNA polymerases.
Topics: Antiviral Agents; Avian Myeloblastosis Virus; Base Sequence; Cell Line; Dideoxynucleotides; DNA Polymerase II; DNA Polymerase III; DNA-Directed DNA Polymerase; HIV; Humans; Molecular Sequence Data; Moloney murine leukemia virus; Nucleic Acid Synthesis Inhibitors; Oligonucleotide Probes; Reverse Transcriptase Inhibitors; Substrate Specificity; Thymine Nucleotides; Zidovudine | 1990 |
[Comparative inhibitory analysis of DNA biosynthesis catalyzed by retrovirus reverse transcriptase].
Topics: Avian Myeloblastosis Virus; Avian Sarcoma Viruses; Catalysis; Chemical Phenomena; Chemistry; DNA; HIV; Oligodeoxyribonucleotides; Poly A; Retroviridae; Reverse Transcriptase Inhibitors; Templates, Genetic; Zidovudine | 1990 |
Export and one-step purification from Escherichia coli of a MalE-CD4 hybrid protein that neutralizes HIV in vitro.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; ATP-Binding Cassette Transporters; Base Sequence; Blotting, Western; Carrier Proteins; CD4 Antigens; Chromatography, Affinity; Cloning, Molecular; Dose-Response Relationship, Drug; Escherichia coli; Escherichia coli Proteins; Gene Expression; HIV; In Vitro Techniques; Maltose-Binding Proteins; Molecular Sequence Data; Monosaccharide Transport Proteins; Peptide Mapping; Periplasmic Binding Proteins; Plasmids; Recombinant Fusion Proteins; RNA-Directed DNA Polymerase; Zidovudine | 1990 |
Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors.
Topics: ADP Ribose Transferases; Bacterial Toxins; CD4 Antigens; Cells, Cultured; Didanosine; Drug Synergism; Exotoxins; HIV; HIV Infections; Humans; Immunotoxins; In Vitro Techniques; Pseudomonas aeruginosa Exotoxin A; Reverse Transcriptase Inhibitors; T-Lymphocytes; Virulence Factors; Virus Replication; Zidovudine | 1990 |
Antileukemic activity of Viva-Natural, a dietary seaweed extract, on Rauscher murine leukemia in comparison with anti-HIV agents, azidothymidine, dextran sulfate and pentosan polysulfate.
Topics: Animals; Antineoplastic Agents; Cell Line; Dextran Sulfate; Female; HIV; Leukemia, Experimental; Male; Mice; Mice, Inbred BALB C; Pentosan Sulfuric Polyester; Plant Extracts; Rauscher Virus; Seaweed; Splenomegaly; Zidovudine | 1991 |
Anti-human immunodeficiency virus synergism by zidovudine (3'-azidothymidine) and didanosine (dideoxyinosine) contrasts with their additive inhibition of normal human marrow progenitor cells.
Topics: Bone Marrow; Bone Marrow Cells; Bone Marrow Diseases; Cell Division; Colony-Forming Units Assay; Didanosine; Drug Synergism; Erythroid Precursor Cells; HIV; Humans; In Vitro Techniques; RNA-Directed DNA Polymerase; Stem Cells; Zidovudine | 1991 |
Combined therapy with recombinant granulocyte colony-stimulating factor and erythropoietin decreases hematologic toxicity from zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Blood Cell Count; Cell Survival; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combination; Erythropoietin; Ganciclovir; Gene Products, gag; Granulocyte Colony-Stimulating Factor; Hemoglobins; HIV; HIV Core Protein p24; Humans; Injections, Subcutaneous; Neutropenia; Opportunistic Infections; Recombinant Proteins; Viral Core Proteins; Virus Replication; Zidovudine | 1991 |
Zidovudine resistance predicted by direct detection of mutations in DNA from HIV-infected lymphocytes.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Base Sequence; Cell Line; Cloning, Molecular; DNA, Viral; Drug Resistance, Microbial; HeLa Cells; HIV; Humans; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; RNA-Directed DNA Polymerase; T-Lymphocytes; Zidovudine | 1991 |
Inhibition of the RNase H activity of HIV reverse transcriptase by azidothymidylate.
Topics: Antiviral Agents; Cloning, Molecular; Deoxyribonucleotides; Dideoxynucleotides; Endoribonucleases; Escherichia coli; HIV; Kinetics; Nucleic Acid Synthesis Inhibitors; Recombinant Proteins; Reverse Transcriptase Inhibitors; Ribonuclease H; Ribonucleotides; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine | 1991 |
Phosphatidylazidothymidine. Mechanism of antiretroviral action in CEM cells.
Topics: Cell Line; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Glycerophospholipids; HIV; Phosphatidic Acids; Retroviridae; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Zidovudine | 1991 |
The characterization of EIAV reverse transcriptase and its inhibition by 5'-triphosphates of 2'-deoxyuridine analogs, PFA and PAA.
Topics: Antiviral Agents; Dideoxynucleotides; Foscarnet; HIV; Infectious Anemia Virus, Equine; Phosphonoacetic Acid; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine | 1990 |
Synergistic combinations and peptides in the inhibition of human immunodeficiency virus.
Topics: Alpha-Globulins; Amino Acid Sequence; Antiviral Agents; Cell Line; Dideoxynucleosides; Drug Synergism; Foscarnet; HIV; Humans; Molecular Sequence Data; Oligopeptides; Phosphonoacetic Acid; Proteins; Reverse Transcriptase Inhibitors; Serine Proteinase Inhibitors; Virus Replication; Zidovudine | 1991 |
Zidovudine-resistant human immunodeficiency virus selected by passage in cell culture.
Topics: Base Sequence; Cell Line; Cloning, Molecular; Codon; Drug Resistance, Microbial; Escherichia coli; HIV; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligonucleotide Probes; Polymerase Chain Reaction; RNA-Directed DNA Polymerase; Viral Plaque Assay; Zidovudine | 1991 |
Potential use of human stem cell factor as adjunctive therapy for human immunodeficiency virus-related cytopenias.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Anemia; Colony-Forming Units Assay; Erythroid Precursor Cells; Erythropoietin; Granulocytes; Hematopoietic Cell Growth Factors; HIV; HIV Infections; Humans; Lymphocytes; Macrophages; Monocytes; Neutropenia; Recombinant Proteins; Stem Cell Factor; Thrombocytopenia; Virus Replication; Zidovudine | 1991 |
Alpha-lipoic acid is an effective inhibitor of human immuno-deficiency virus (HIV-1) replication.
Topics: Cells, Cultured; Cytopathogenic Effect, Viral; HIV; HIV Reverse Transcriptase; HIV-1; RNA-Directed DNA Polymerase; T-Lymphocytes; Thioctic Acid; Viral Plaque Assay; Virus Replication; Zidovudine | 1991 |
Metabolism of 4'-azidothymidine. A compound with potent and selective activity against the human immunodeficiency virus.
Topics: Cell Line; DNA; HIV; Humans; Kinetics; Phosphorylation; Substrate Specificity; T-Lymphocytes; Thymidine; Thymidine Kinase; Thymidine Phosphorylase; Virus Replication; Zidovudine | 1992 |
Plasma viremia in human immunodeficiency virus infection: relationship to stage of disease and antiviral treatment.
Topics: AIDS-Related Complex; Chi-Square Distribution; HIV; HIV Core Protein p24; HIV Infections; Humans; Regression Analysis; Sensitivity and Specificity; Viremia; Virus Cultivation; Zidovudine | 1992 |
Enhancement of HIV-specific cytotoxic T lymphocyte responses by zidovudine (AZT) treatment.
Topics: Acquired Immunodeficiency Syndrome; Cells, Cultured; Follow-Up Studies; HIV; Humans; T-Lymphocytes, Cytotoxic; Zidovudine | 1992 |
Decrease in HIV provirus in peripheral blood mononuclear cells during zidovudine and human rIL-2 administration.
Topics: DNA, Viral; Follow-Up Studies; HIV; HIV Infections; HIV Seropositivity; Humans; Interleukin-2; Leukocytes, Mononuclear; Polymerase Chain Reaction; Proviruses; Recombinant Proteins; Zidovudine | 1992 |
Synthesis of 1-(3-azido-2,3-dideoxy-beta-D-allofuranosyl)thymine, 1-(2,3-dideoxy-beta-D-allofuranosyl)thymine, and 1-(2,3-dideoxy-beta-D-erythro-hex-2-enofuranosyl)thymine.
Topics: Antiviral Agents; Dideoxynucleosides; HIV; Molecular Structure; Zidovudine | 1991 |
A new method of synthesis of 3'-mercapto-3'-deoxythymidine.
Topics: Antiviral Agents; Cell Line; HIV; Humans; T-Lymphocytes; Thymidine; Zidovudine | 1991 |
Mechanisms of inhibitions of DNA polymerase gamma by nucleotide analogues having anti-HIV activities.
Topics: Animals; Antiviral Agents; Cattle; Dideoxynucleotides; DNA Polymerase III; HIV; Male; Thymine Nucleotides; Zidovudine | 1991 |
[AIDS: initial results of combination therapy. AIDS and ARC--alternating or intermittent medication].
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; CD4 Antigens; Combined Modality Therapy; HIV; Humans; Immunotherapy, Adoptive; Interferon Type I; Recombinant Proteins; Zalcitabine; Zidovudine | 1991 |
Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity.
Topics: Antiviral Agents; Cell Line; Cytarabine; Didanosine; Dideoxynucleosides; DNA, Mitochondrial; HIV; Humans; Lymphocyte Activation; Nucleosides; Stavudine; T-Lymphocytes; Zalcitabine; Zidovudine | 1991 |
Acquired immunodeficiency syndrome. Cerebrospinal fluid findings in patients before and during long-term oral zidovudine therapy.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Cerebrospinal Fluid; Female; HIV; Humans; Male; Middle Aged; Zidovudine | 1991 |
Fertility parameters in men infected with human immunodeficiency virus.
Topics: Acquired Immunodeficiency Syndrome; Adult; Fertility; HIV; HIV Infections; HIV Seropositivity; Humans; Male; Semen; Sperm Count; Spermatozoa; Zidovudine | 1991 |
Human immunodeficiency virus (HIV)-infected tumor xenografts as an in vivo model for antiviral therapy: role of alpha/beta interferon in restriction of tumor growth in nude mice injected with HIV-infected U937 tumor cells.
Topics: Animals; Antibodies; Cell Division; Disease Models, Animal; Female; Gene Products, gag; HIV; HIV Antigens; HIV Core Protein p24; HIV Infections; Humans; Immunosuppression Therapy; Interferon Type I; Lymphoma; Male; Mice; Mice, Nude; Neoplasm Transplantation; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Viral Core Proteins; Virus Replication; Zidovudine | 1991 |
Human immunodeficiency virus infection of human lymph nodes in the SCID-hu mouse.
Topics: Animals; Antiviral Agents; Didanosine; DNA, Viral; HIV; HIV Infections; Humans; Immunohistochemistry; Immunologic Deficiency Syndromes; Lymph Nodes; Macrophages; Mice; Nucleic Acid Hybridization; Polymerase Chain Reaction; T-Lymphocytes; Transplantation, Heterologous; Zidovudine | 1991 |
Modeling zidovudine therapy: a cost-effectiveness analysis.
Topics: Acquired Immunodeficiency Syndrome; Cost-Benefit Analysis; HIV; Humans; Male; Models, Theoretical; Sensitivity and Specificity; Time Factors; United States; Zidovudine | 1991 |
[Antiretroviral therapy in Switzerland 1991].
Topics: Acquired Immunodeficiency Syndrome; Didanosine; HIV; Humans; RNA, Viral; Virus Replication; Zidovudine | 1991 |
Biochemical and genetical analysis of AZT-resistant HIV-mutants.
Topics: Amino Acid Sequence; Antiviral Agents; Base Sequence; Cells, Cultured; Cloning, Molecular; DNA, Viral; Drug Resistance, Microbial; HIV; Humans; Monocytes; Polymerase Chain Reaction; Virus Replication; Zidovudine | 1991 |
Zidovudine after occupational exposure to HIV.
Topics: HIV; HIV Infections; Humans; Occupational Diseases; Occupational Exposure; Zidovudine | 1991 |
Synthesis and biological evaluation of dinucleoside methylphosphonates of 3'-azido-3'-deoxythymidine and 2', 3'-dideoxycytidine.
Topics: Animals; Antineoplastic Agents; Deoxycytosine Nucleotides; Drug Evaluation, Preclinical; HIV; Hydrolysis; Mice; Mice, Inbred C3H; Moloney murine sarcoma virus; Thymine Nucleotides; Tumor Cells, Cultured; Virus Replication; Zalcitabine; Zidovudine | 1990 |
AIDS meeting: unexpected progress.
Topics: Acquired Immunodeficiency Syndrome; Congresses as Topic; HIV; San Francisco; Zidovudine | 1990 |
Hybrid pharmacokinetic models to describe anti-HIV nucleoside brain disposition following parent and prodrug administration in mice.
Topics: Animals; Antiviral Agents; Brain; Dihydropyridines; Female; HIV; Mice; Models, Biological; Nucleosides; Prodrugs; Zidovudine | 1991 |
Characterization of genetic variation and 3'-azido-3'-deoxythymidine- resistance mutations of human immunodeficiency virus by the RNase A mismatch cleavage method.
Topics: Acquired Immunodeficiency Syndrome; Base Sequence; Codon; DNA, Viral; Drug Resistance, Microbial; Genes, Viral; Genetic Variation; HIV; HIV Envelope Protein gp120; Humans; Molecular Sequence Data; Mutation; Nucleic Acid Hybridization; Polymerase Chain Reaction; Ribonuclease, Pancreatic; Viral Proteins; Zidovudine | 1991 |
Programmed activation of T-lymphocytes. A theoretical basis for short term treatment of AIDS with azidothymidine.
Topics: Acquired Immunodeficiency Syndrome; DNA, Viral; HIV; Humans; Lymphocyte Activation; T-Lymphocytes; Virus Replication; Zidovudine | 1991 |
Use of a focal infectivity assay for testing susceptibility of HIV to antiviral agents.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Gene Products, env; HeLa Cells; HIV; HIV Antibodies; HIV Envelope Protein gp120; HIV Envelope Protein gp160; Humans; Immunoenzyme Techniques; Immunoglobulin G; Immunotoxins; Interferon Type I; Protein Precursors; Recombinant Proteins; Ricin; Zidovudine | 1991 |
In vivo prevalence of azidothymidine (AZT) resistance mutations in an AIDS patient before and after AZT therapy.
Topics: Acquired Immunodeficiency Syndrome; Adult; Amino Acid Sequence; Base Sequence; DNA, Viral; Drug Resistance, Microbial; Genes, pol; HIV; Humans; Male; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Sequence Alignment; Time Factors; Zidovudine | 1991 |
[AIDS: the outlook from 1991].
Topics: Acquired Immunodeficiency Syndrome; CD4 Antigens; HIV; Humans; T-Lymphocytes; Viral Vaccines; Zidovudine | 1991 |
Synthesis and anti-HIV evaluation of some phosphoramidate derivatives of AZT: studies on the effect of chain elongation on biological activity.
Topics: Cells, Cultured; Deoxyribonucleotides; DNA; Dose-Response Relationship, Drug; HIV; HIV Infections; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Prodrugs; Structure-Activity Relationship; Thymine Nucleotides; Zidovudine | 1990 |
2'-Azido-2',3'-dideoxythymidine: synthesis and crystal structure of a 2'-substituted dideoxynucleoside.
Topics: Antiviral Agents; Crystallography; Dideoxynucleosides; HIV; Humans; In Vitro Techniques; Molecular Structure; Structure-Activity Relationship; Virus Replication; X-Ray Diffraction; Zidovudine | 1990 |
Activation of a beta-galactosidase recombinant provirus: application to titration of human immunodeficiency virus (HIV) and HIV-infected cells.
Topics: beta-Galactosidase; Blotting, Southern; Cell Line; Clone Cells; Galactosidases; HIV; HIV-1; Humans; Kinetics; Lymphocytes; Plasmids; Proviruses; Restriction Mapping; RNA, Viral; Simian Immunodeficiency Virus; Transcriptional Activation; Transfection; Virus Activation; Zidovudine | 1990 |
Effect of stage of disease and drug dose on zidovudine susceptibilities of isolates of human immunodeficiency virus.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; CD4 Antigens; Gene Products, gag; HIV; HIV Core Protein p24; Humans; Leukocyte Count; Microbial Sensitivity Tests; Time Factors; Viral Core Proteins; Zidovudine | 1990 |
Clinical response to dideoxyinosine in patients with HIV infection resistant to zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Didanosine; Drug Resistance, Microbial; HIV; Humans; Zidovudine | 1990 |
[Virological monitoring in subjects with HIV infection under treatment with zidovudine (AZT)].
Topics: Gene Products, gag; HIV; HIV Core Protein p24; HIV Infections; Humans; Viral Core Proteins; Viremia; Virus Replication; Zidovudine | 1990 |
Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethyl)adenine.
Topics: Adenine; Animals; Antiviral Agents; Cats; Cell Line; HIV; Immunologic Deficiency Syndromes; Opportunistic Infections; Organophosphonates; Retroviridae; Retroviridae Infections; T-Lymphocytes; Virus Replication; Zidovudine | 1990 |
Inhibitory effects of potent inhibitors of human immunodeficiency virus and cytomegalovirus on the growth of human granulocyte-macrophage progenitor cells in vitro.
Topics: Adenine; Adult; Antiviral Agents; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Cidofovir; Cytomegalovirus; Cytosine; Foscarnet; Ganciclovir; Granulocytes; Hematopoietic Stem Cells; HIV; Humans; Macrophages; Organophosphonates; Organophosphorus Compounds; Phosphonoacetic Acid; Zidovudine | 1990 |
Vesicular changes in the myopathies of AIDS. Ultrastructural observations and their relationship to zidovudine treatment.
Topics: Acquired Immunodeficiency Syndrome; Adult; Biopsy; Cytopathogenic Effect, Viral; Cytoplasm; HIV; Humans; Inclusion Bodies; Male; Microscopy, Electron; Middle Aged; Muscles; Muscular Atrophy; Myofibrils; Necrosis; Sarcoplasmic Reticulum; Zidovudine | 1990 |
Strategies for the combination therapy of HIV infection.
Topics: Acyclovir; Antiviral Agents; Drug Therapy, Combination; HIV; HIV Infections; Humans; Virus Replication; Zalcitabine; Zidovudine | 1990 |
Oral melanotic macules in patients infected with human immunodeficiency virus.
Topics: Adult; Chi-Square Distribution; DNA, Viral; Female; Herpesvirus 4, Human; HIV; HIV Infections; Humans; Lip Diseases; Male; Melanosis; Middle Aged; Mouth Diseases; Mouth Mucosa; Nucleic Acid Hybridization; Zidovudine | 1990 |
Potential anti-HIV active pyranoid analogs of AZT.
Topics: Antiviral Agents; HIV; Magnetic Resonance Spectroscopy; Zidovudine | 1990 |
Induction of monocyte proliferation and HIV expression by IL-3 does not interfere with anti-viral activity of zidovudine.
Topics: Cell Division; Cells, Cultured; HIV; Humans; Interleukin-3; Monocytes; Virus Replication; Zidovudine | 1990 |
Cellular metabolism of 3'-azido-2',3'-dideoxyuridine with formation of 5'-O-diphosphohexose derivatives by previously unrecognized metabolic pathways for 2'-deoxyuridine analogs.
Topics: Antiviral Agents; Bone Marrow; Chromatography, High Pressure Liquid; Dideoxynucleotides; HIV; Humans; Leukocytes, Mononuclear; Thymine Nucleotides; Zidovudine | 1990 |
Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impairment of anti-human immunodeficiency virus activity.
Topics: Anemia; Animals; Cell Line; Cytopathogenic Effect, Viral; Female; HIV; Leukopenia; Mice; Mice, Inbred BALB C; Uracil; Uridine; Zidovudine | 1990 |
Interactive laser cytometric analysis of retroviral protein expression in HIV-infected lymphocytic cell lines.
Topics: Cell Line; Fluorescent Antibody Technique; HIV; HIV Antigens; Humans; Kinetics; Lasers; Microscopy, Fluorescence; Viral Envelope Proteins; Zidovudine | 1990 |
Progress in targeted therapy against human immunodeficiency virus [corrected].
Topics: Acquired Immunodeficiency Syndrome; Animals; Antiviral Agents; Cytopathogenic Effect, Viral; Dideoxynucleosides; DNA, Viral; Genes, Viral; HIV; Humans; Protein Biosynthesis; Receptors, Antigen, T-Cell; RNA, Viral; Viral Envelope Proteins; Virus Replication; Zidovudine | 1990 |
Decreased in vitro susceptibility to zidovudine of HIV isolates obtained from patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Cell Line; Cytopathogenic Effect, Viral; HIV; Humans; Microbial Sensitivity Tests; Virus Replication; Zidovudine | 1990 |
Suppression of HIV infection in AZT-treated SCID-hu mice.
Topics: Animals; DNA, Viral; HIV; HIV Infections; Humans; Mice; Mice, Mutant Strains; Nucleic Acid Hybridization; Polymerase Chain Reaction; Spleen; Thymus Gland; Transplantation, Heterologous; Zidovudine | 1990 |
HIV eliminated in AIDS patient with lymphoma.
Topics: Acquired Immunodeficiency Syndrome; Bone Marrow Transplantation; Combined Modality Therapy; HIV; Hodgkin Disease; Male; Zidovudine | 1990 |
Synthesis and antiretroviral activity of phospholipid analogs of azidothymidine and other antiviral nucleosides.
Topics: Antiviral Agents; Cell Line; HIV; Humans; Indicators and Reagents; Liposomes; Magnetic Resonance Spectroscopy; Nucleosides; Phospholipids; Structure-Activity Relationship; Virus Replication; Zidovudine | 1990 |
2'-azido-2',3'-dideoxypyrimidine nucleosides. Synthesis and antiviral activity against human immunodeficiency virus.
Topics: Antiviral Agents; HIV; Humans; Zidovudine | 1990 |
[HIV infection in adults and children. Approaches to therapy. Position of the scientific consultant of the federal medical council].
Topics: Adult; Child; Germany, West; HIV; HIV Infections; Humans; Zidovudine | 1990 |
Synthesis of 1-methyl-5-(3-azido-2,3-dideoxy-beta-D-erythro-pentofuranosyl)uracil and 1-methyl-5-(3-azido-2,3-dideoxy-2-fluoro-beta-D-arabinofuranosyl)uracil. The C-nucleoside isostere of 3'-azido-3'-deoxythymidine and its 2'-"up"-fluoro analogue.
Topics: Antiviral Agents; Cell Line; HIV; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Zidovudine | 1990 |
Activities of (-)-carbovir and 3'-azido-3'-deoxythymidine against human immunodeficiency virus in vitro.
Topics: Antiviral Agents; Cell Line; Cell Survival; Dideoxynucleosides; HIV; Humans; Virus Replication; Zidovudine | 1990 |
Lipid conjugates of antiretroviral agents. I. Azidothymidine-monophosphate-diglyceride: anti-HIV activity, physical properties, and interaction with plasma proteins.
Topics: Antiviral Agents; Blood Proteins; Cells, Cultured; Chemical Phenomena; Chemistry, Physical; Diglycerides; Dose-Response Relationship, Drug; Glycerides; HIV; Humans; In Vitro Techniques; Liposomes; Retroviridae Proteins; Virus Replication; Zidovudine | 1990 |
Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.
Topics: Antiviral Agents; Cell Survival; HIV; Humans; Kinetics; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Reverse Transcriptase Inhibitors; Thymidine; Thymidine Monophosphate; Thymine Nucleotides; Virus Replication; Zidovudine | 1986 |
Inhibition of replication and cytopathic effect of human T cell lymphotropic virus type III/lymphadenopathy-associated virus by 3'-azido-3'-deoxythymidine in vitro.
Topics: Antigens, Viral; Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; HIV; HIV Antigens; Humans; Reverse Transcriptase Inhibitors; Thymidine; Viral Plaque Assay; Virus Replication; Zidovudine | 1986 |
Ribavirin antagonizes the effect of azidothymidine on HIV replication.
Topics: Cell Line; HIV; Humans; Lymphocytes; Monocytes; Phosphorylation; Phytohemagglutinins; Ribavirin; Ribonucleosides; RNA-Directed DNA Polymerase; Thymidine; Virus Replication; Zidovudine | 1987 |
Antiviral therapy.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Antiviral Agents; Cytomegalovirus; DNA, Viral; Drug Resistance, Microbial; Herpesvirus 3, Human; Herpesvirus 4, Human; HIV; Humans; Interferons; Nucleosides; Reverse Transcriptase Inhibitors; Ribavirin; RNA, Messenger; RNA, Viral; Simplexvirus; Thymidine; Virus Diseases; Virus Physiological Phenomena; Virus Replication; Zidovudine | 1987 |
Dextran sulphate, a potent anti-HIV agent in vitro having synergism with zidovudine.
Topics: Antiviral Agents; Dextran Sulfate; Dextrans; Drug Synergism; HIV; Humans; Thymidine; Zidovudine | 1987 |
Inhibition of the reverse transcriptase from HIV by 3'-azido-3'-deoxythymidine triphosphate and its threo analogue.
Topics: Antiviral Agents; Chemical Phenomena; Chemistry; Dideoxynucleotides; HIV; Humans; Kinetics; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine | 1987 |
Conformational properties of 3'-azido-3'deoxy-thymidine (AZT), an inhibitor of HIV reverse transcriptase.
Topics: Antiviral Agents; HIV; Models, Molecular; Molecular Conformation; Reverse Transcriptase Inhibitors; Thymidine; Zidovudine | 1987 |
Anti-HIV synergy between dextran sulphate and zidovudine.
Topics: Dextran Sulfate; Dextrans; Drug Synergism; HIV; Thymidine; Zidovudine | 1987 |
Potent and selective in vitro activity of 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus.
Topics: Antiviral Agents; Deoxycytidine; HIV; Humans; Monocytes; Retroviridae Proteins; RNA-Directed DNA Polymerase; Stavudine; Thymidine; Virus Replication; Zidovudine | 1987 |
Anti-HIV synergism between dextran sulphate and zidovudine.
Topics: Antiviral Agents; Dextran Sulfate; Dextrans; Drug Synergism; HIV; Humans; Thymidine; Zidovudine | 1987 |
Synergistic activity of granulocyte-macrophage colony-stimulating factor and 3'-azido-3'-deoxythymidine against human immunodeficiency virus in vitro.
Topics: Antiviral Agents; Cell Line; Drug Synergism; Fluorescent Antibody Technique; HIV; Humans; Interleukin-3; Recombinant Proteins; RNA-Directed DNA Polymerase; Thymidine; Virus Replication; Zidovudine | 1987 |
Resumption of virus production after human immunodeficiency virus infection of T lymphocytes in the presence of azidothymidine.
Topics: Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; DNA, Viral; Drug Resistance, Microbial; HIV; Humans; RNA-Directed DNA Polymerase; T-Lymphocytes; Thymidine; Virus Replication; Zidovudine | 1987 |
3'-Azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase.
Topics: Anti-Bacterial Agents; Autoradiography; Cells, Cultured; Dideoxynucleotides; Electrophoresis, Polyacrylamide Gel; HIV; Nucleic Acid Synthesis Inhibitors; Peptide Chain Termination, Translational; Reverse Transcriptase Inhibitors; Substrate Specificity; Templates, Genetic; Thymine Nucleotides; Zidovudine | 1987 |
Conformation and sandwiching of bases by azido groups in the crystal structure of 3'-azido-3'-deoxy-thymidine (AZT), an antiviral agent that inhibits HIV reverse transcriptase.
Topics: Azides; Dideoxynucleotides; HIV; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine | 1988 |
Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells.
Topics: Antigens, Differentiation, T-Lymphocyte; Cell Line; Dextran Sulfate; Dextrans; Dideoxynucleosides; DNA, Viral; Fluorescent Antibody Technique; HIV; HIV Envelope Protein gp120; Immunologic Techniques; Retroviridae Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Suramin; T-Lymphocytes, Helper-Inducer; Thymidine; Viral Fusion Proteins; Virion; Zidovudine | 1988 |
1-(2,3-Anhydro-beta-D-lyxofuranosyl)cytosine derivatives as potential inhibitors of the human immunodeficiency virus.
Topics: Ancitabine; Chemical Phenomena; Chemistry; Cytarabine; Cytidine; HIV; Magnetic Resonance Spectroscopy; Mass Spectrometry; Thymidine; Uracil; Zidovudine | 1988 |
Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cell Line, Transformed; Colorimetry; Cytopathogenic Effect, Viral; Dextran Sulfate; Dextrans; Dideoxynucleosides; Drug Evaluation, Preclinical; Heparin; HIV; Humans; Tetrazolium Salts; Thiazoles; Zalcitabine; Zidovudine | 1988 |
Dextran sulfate as an inhibitor against the human immunodeficiency virus.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Dextran Sulfate; Dextrans; HIV; Humans; Interferon Inducers; Microbial Sensitivity Tests; Molecular Weight; Reverse Transcriptase Inhibitors; T-Lymphocytes, Helper-Inducer; Viral Plaque Assay; Virion; Zidovudine | 1988 |
An analysis of the inhibition of replication of HIV and MuLV by some 3'-blocked pyrimidine analogs.
Topics: Animals; Cells, Cultured; HIV; Male; Mice; Mice, Inbred BALB C; Molecular Conformation; Moloney murine leukemia virus; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Virus Replication; Zidovudine | 1989 |
A rapid and simple colorimetric test for the study of anti-HIV agents.
Topics: Antiviral Agents; Cell Line; Colorimetry; Cytopathogenic Effect, Viral; Formazans; HIV; Humans; Microbial Sensitivity Tests; Ribavirin; RNA-Directed DNA Polymerase; Tetrazolium Salts; Thiazoles; Virus Replication; Zidovudine | 1988 |
Nucleotide dimers suppress HIV expression in vitro.
Topics: Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; Dinucleoside Phosphates; HIV; HIV Antigens; Microbial Sensitivity Tests; Reverse Transcriptase Inhibitors; Zidovudine | 1988 |
HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Dideoxynucleosides; Drug Resistance; Foscarnet; HeLa Cells; HIV; HIV Core Protein p24; Humans; Microbial Sensitivity Tests; Phosphonoacetic Acid; Retroviridae Proteins; Reverse Transcriptase Inhibitors; Viral Plaque Assay; Virus Replication; Zalcitabine; Zidovudine | 1989 |
Kinetics and inhibition of reverse transcriptase from human and simian immunodeficiency viruses.
Topics: Deoxyguanine Nucleotides; Dideoxynucleotides; HIV; Humans; Kinetics; Reverse Transcriptase Inhibitors; Simian Immunodeficiency Virus; Thymine Nucleotides; Zidovudine | 1988 |
In vitro evaluation of mismatched double-stranded RNA (ampligen) for combination therapy in the treatment of acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Alkaloids; Amphotericin B; Antiviral Agents; Drug Therapy, Combination; Foscarnet; HIV; Humans; In Vitro Techniques; Indolizines; Interferon beta-1a; Interferon beta-1b; Interferon Type I; Interferon-beta; Interferon-gamma; Interferons; Microbial Sensitivity Tests; Phosphonoacetic Acid; Recombinant Proteins; Ribavirin; RNA, Double-Stranded; Zidovudine | 1989 |
Pharmacokinetics of zidovudine and concomitant inosine-pranobex in AIDS patients.
Topics: Acquired Immunodeficiency Syndrome; Drug Therapy, Combination; HIV; Humans; Inosine; Inosine Pranobex; Time Factors; Zidovudine | 1988 |
Comparison of the effect of Carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases.
Topics: Deoxyguanine Nucleotides; Dideoxynucleosides; Dideoxynucleotides; DNA Primase; HIV; Humans; Nucleic Acid Synthesis Inhibitors; Reverse Transcriptase Inhibitors; RNA Nucleotidyltransferases; Thymine Nucleotides; Zidovudine | 1989 |
Further characterization of sulfated homopolysaccharides as anti-HIV agents.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Dextran Sulfate; Dextrans; Drug Synergism; HIV; Humans; Leukocytes, Mononuclear; Polysaccharides; Reverse Transcriptase Inhibitors; Zidovudine | 1989 |
Phosphorylation of 3'-azido-2',3'-dideoxyuridine and preferential inhibition of human and simian immunodeficiency virus reverse transcriptases by its 5'-triphosphate.
Topics: Cells, Cultured; Chromatography, High Pressure Liquid; DNA Polymerase II; HIV; Humans; Kinetics; Phosphorylation; Phosphotransferases; Reverse Transcriptase Inhibitors; Simian Immunodeficiency Virus; Thymidine Kinase; Zidovudine | 1989 |
Zidovudine resistant HIV.
Topics: Acquired Immunodeficiency Syndrome; Drug Resistance, Microbial; HIV; Humans; Zidovudine | 1989 |
Isolation of drug-resistant variants of HIV-1 from patients on long-term zidovudine therapy. Canadian Zidovudine Multi-Centre Study Group.
Topics: Acquired Immunodeficiency Syndrome; Drug Resistance, Microbial; HIV; Humans; Zidovudine | 1989 |
Recombinant human interferon-beta suppresses the replication of HIV and acts synergistically with AZT.
Topics: Cells, Cultured; Cytopathogenic Effect, Viral; Drug Synergism; Gene Products, gag; HIV; HIV Antigens; HIV Core Protein p24; Humans; Interferon beta-1a; Interferon beta-1b; Interferon Type I; Interferon-beta; Recombinant Proteins; Viral Core Proteins; Virus Replication; Zidovudine | 1989 |
Comparative assessment of antiretrovirals in human monocyte-macrophages and lymphoid cell lines acutely and chronically infected with the human immunodeficiency virus.
Topics: Antiviral Agents; Dose-Response Relationship, Drug; Foscarnet; Gene Products, gag; HIV; HIV Antigens; HIV Core Protein p24; Humans; Interferon Type I; Macrophages; Monocytes; Phosphonoacetic Acid; RNA, Viral; Tumor Cells, Cultured; Viral Core Proteins; Virus Replication; Zidovudine | 1989 |
Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds.
Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Deoxycytidine; Deoxyribonucleotides; Dideoxynucleosides; Dose-Response Relationship, Drug; HIV; Humans; Mice; Phosphorylation; Sarcoma Viruses, Murine; Solubility; Stavudine; Thymidine; Zidovudine | 1989 |
Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages.
Topics: Antiviral Agents; Biological Transport; Bone Marrow; Bone Marrow Cells; Cell Survival; Dideoxynucleosides; Dipyridamole; Drug Synergism; HIV; Humans; In Vitro Techniques; Interferon Type I; Macrophages; Monocytes; Virus Replication; Zalcitabine; Zidovudine | 1989 |
In vitro bone marrow toxicity of nucleoside analogs against human immunodeficiency virus.
Topics: Antiviral Agents; Bone Marrow Diseases; Colony-Forming Units Assay; Dideoxynucleosides; HIV; Humans; Nucleosides; Zalcitabine; Zidovudine | 1989 |
Human immunodeficiency virus inhibition is prolonged by 3'-azido-3'-deoxythymidine alternating with 2',3'-dideoxycytidine compared with 3'-azido-3'-deoxythymidine alone.
Topics: Antiviral Agents; Cells, Cultured; Dideoxynucleosides; DNA, Viral; HIV; Humans; Time Factors; Virus Replication; Zalcitabine; Zidovudine | 1989 |
[AIDS: small, life-prolonging steps. Antiviral therapy is more efficient--a decrease in side effects].
Topics: Acquired Immunodeficiency Syndrome; HIV; Humans; Zalcitabine; Zidovudine | 1989 |
A comparison of three nucleoside analogs with anti-retroviral activity on immune and hematopoietic functions in mice: in vitro toxicity to precursor cells and microstromal environment.
Topics: Acquired Immunodeficiency Syndrome; Animals; Antigen-Antibody Reactions; Antiviral Agents; Bone Marrow; Dideoxyadenosine; Female; Hematopoiesis; HIV; Immunity, Cellular; Macrophages; Mice; Mice, Inbred C57BL; Spleen; Stem Cells; T-Lymphocytes; Virus Replication; Zalcitabine; Zidovudine | 1989 |
The antiretroviral and cytostatic activity, and metabolism of 3'-azido-2',3'-dideoxythymidine, 3'-fluoro-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly cell type-dependent.
Topics: Antiviral Agents; Cell Division; Cell Line; Dideoxynucleosides; HIV; Humans; Virus Replication; Zalcitabine; Zidovudine | 1989 |
Association between biological properties of human immunodeficiency virus variants and risk for AIDS and AIDS mortality.
Topics: Acquired Immunodeficiency Syndrome; Follow-Up Studies; HIV; HIV Seropositivity; Humans; Longitudinal Studies; Male; Retrospective Studies; Risk Factors; T-Lymphocytes; Time Factors; Virus Replication; Zidovudine | 1989 |
AIDS therapy.
Topics: Acquired Immunodeficiency Syndrome; CD4-Positive T-Lymphocytes; HIV; Humans; Zidovudine | 1989 |
2'-Deoxycytidine protects normal human bone marrow progenitor cells in vitro against the cytotoxicity of 3'-azido-3'-deoxythymidine with preservation of antiretroviral activity.
Topics: Bone Marrow; CD4-Positive T-Lymphocytes; Cell Survival; Cells, Cultured; Colony-Forming Units Assay; Deoxycytidine; Deoxycytosine Nucleotides; Hematopoiesis; HIV; Humans; Phosphorylation; Thymine Nucleotides; Zidovudine | 1989 |
Cell-to-cell transmission of human immunodeficiency virus type 1 in the presence of azidothymidine and neutralizing antibody.
Topics: Acquired Immunodeficiency Syndrome; Cells, Cultured; HIV; HIV Antibodies; HIV Seropositivity; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Virus Replication; Zidovudine | 1989 |
Pharmacokinetics of orally administered zidovudine among patients with hemophilia and asymptomatic human immunodeficiency virus (HIV) infection.
Topics: Administration, Oral; Chromatography, High Pressure Liquid; Hemophilia A; HIV; HIV Seropositivity; Humans; Liver Function Tests; Male; Metabolic Clearance Rate; Zidovudine | 1989 |
Microenvironmental toxicity of azidothymidine: partial sparing with hemin.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Division; Dose-Response Relationship, Drug; Erythropoiesis; Hematopoiesis; Hematopoietic Stem Cells; Heme; Hemin; HIV; HIV Antigens; Humans; Mice; Zidovudine | 1989 |
Anti-HIV drugs: comparative toxicities in murine fetal liver and bone marrow erythroid progenitor cells.
Topics: Animals; Antiviral Agents; Bone Marrow Cells; Cells, Cultured; Colony-Forming Units Assay; Dideoxynucleosides; Fetus; Hematopoietic Stem Cells; HIV; Liver; Mice; Ribavirin; Zalcitabine; Zidovudine | 1989 |
Cellular pharmacology of 2',3'-dideoxy-2',3'-didehydrothymidine, a nucleoside analog active against human immunodeficiency virus.
Topics: Cells, Cultured; Chromatography, High Pressure Liquid; HIV; Humans; Nucleosides; Phosphorylation; Thymine Nucleotides; Zidovudine | 1989 |
Inhibition of HIV-1 proviral DNA synthesis and RNA accumulation by mismatched dsRNA.
Topics: Antiviral Agents; Cell Line; DNA, Viral; HIV; Interferon Type I; Nucleic Acid Hybridization; Poly I-C; Poly U; Polyribonucleotides; Recombinant Proteins; RNA, Double-Stranded; RNA, Viral; T-Lymphocytes; Transcription, Genetic; Zidovudine | 1989 |
Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus.
Topics: Antigens, Viral; Antiviral Agents; Cell Line; Cell Survival; Cytopathogenic Effect, Viral; Deoxycytidine; Flow Cytometry; Fluorescent Antibody Technique; HIV; Humans; Thymidine; Zalcitabine; Zidovudine | 1987 |
Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages.
Topics: Adenosine Kinase; Cell Line; Deoxyadenosines; Deoxycytidine; Deoxycytidine Kinase; Dideoxyadenosine; HIV; Humans; Macrophages; Phosphorylation; T-Lymphocytes; Thymidine; Thymidine Kinase; Uridine Kinase; Virus Replication; Zalcitabine; Zidovudine | 1987 |
The in vitro and in vivo anti-retrovirus activity, and intracellular metabolism of 3'-azido-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly dependent on the cell species.
Topics: Animals; Antiviral Agents; Cell Line; Deoxycytidine; HIV; Humans; Mice; Mice, Inbred C3H; Moloney murine sarcoma virus; Retroviridae; Thymidine; Zalcitabine; Zidovudine | 1988 |
Anti-human immunodeficiency virus agent 3'-azido-3'-deoxythymidine inhibits replication of Epstein-Barr virus.
Topics: Cell Line; Cytomegalovirus; Herpesvirus 3, Human; Herpesvirus 4, Human; HIV; Simplexvirus; Thymidine; Virus Replication; Zidovudine | 1988 |
Inhibition of infectivity and replication of HIV-2 and SIV in helper T-cells by 2',3'-dideoxynucleosides in vitro.
Topics: Cytopathogenic Effect, Viral; Deoxyadenosines; Deoxycytidine; Dideoxyadenosine; HIV; In Vitro Techniques; Nucleosides; Retroviridae; T-Lymphocytes, Helper-Inducer; Thymidine; Viral Proteins; Virus Replication; Zalcitabine; Zidovudine | 1988 |
Synergistic interaction of 2',3'-dideoxycytidine and recombinant interferon-alpha-A on replication of human immunodeficiency virus type 1.
Topics: Antiviral Agents; Cell Line; Deoxycytidine; Drug Synergism; HIV; Humans; Interferon Type I; Leukocytes; Recombinant Proteins; Thymidine; Virus Replication; Zalcitabine; Zidovudine | 1988 |
Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2',3'-dideoxynucleosides.
Topics: Antiviral Agents; Deoxycytidine Kinase; Dideoxyadenosine; Dideoxynucleosides; HIV; Humans; In Vitro Techniques; Macrophages; Monocytes; Phosphorylation; Thymidine Kinase; Time Factors; Virus Replication; Zalcitabine; Zidovudine | 1988 |
Potent and selective activity of a new carbocyclic nucleoside analog (carbovir: NSC 614846) against human immunodeficiency virus in vitro.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Molecular Structure; Structure-Activity Relationship; Virus Replication; Zalcitabine; Zidovudine | 1988 |
Heterogeneity of HIV-1 replication and antigen expression in EBV-transformed B cell lines.
Topics: Antigens, Viral; B-Lymphocytes; Cell Line; Cytopathogenic Effect, Viral; Herpesvirus 4, Human; HIV; Humans; Virus Replication; Zidovudine | 1988 |
Recovery of human immunodeficiency virus from ocular tissues in patients with acquired immune deficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Cytomegalovirus Infections; Eye; Eye Enucleation; Fluorescent Antibody Technique; HIV; HIV Antigens; Humans; Male; Retinitis; Zidovudine | 1988 |
Mismatched double-stranded RNA (ampligen) reduces concentration of zidovudine (azidothymidine) required for in-vitro inhibition of human immunodeficiency virus.
Topics: Antiviral Agents; Cell Line; HIV; Humans; Poly I-C; Poly U; Polyribonucleotides; Thymidine; Virus Replication; Zidovudine | 1987 |
Phase I studies of 2',3'-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT).
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Deoxycytidine; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; HIV; Humans; Male; Middle Aged; Thymidine; Zalcitabine; Zidovudine | 1988 |
Resumption of HIV antigen production during continuous zidovudine treatment.
Topics: Acquired Immunodeficiency Syndrome; Antigens, Viral; Antiviral Agents; HIV; Humans; Thymidine; Zidovudine | 1988 |
Isolation of HIV from mononuclear cells of patients receiving zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Antiviral Agents; HIV; Humans; Leukocytes, Mononuclear; Thymidine; Zidovudine | 1988 |
Acute meningo-encephalitis on dose reduction of zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Adult; AIDS-Related Complex; Antiviral Agents; Follow-Up Studies; HIV; Homosexuality; Humans; Male; Meningoencephalitis; Middle Aged; Neutropenia; Thrombocytopenia; Thymidine; Virus Replication; Zidovudine | 1988 |
IVth international AIDS conference.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antibodies, Viral; Child; Congresses as Topic; Female; Health Education; HIV; HIV Antibodies; Humans; Male; Sweden; Thymidine; Zidovudine | 1988 |
Acute meningoencephalitis on dose reduction of zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Acute Disease; HIV; Humans; Meningoencephalitis; Thymidine; Virus Replication; Zidovudine | 1988 |
A highly reliable, sensitive, flow cytometric/fluorometric assay for the evaluation of the anti-HIV activity of antiviral compounds in MT-4 cells.
Topics: Acquired Immunodeficiency Syndrome; CD4-Positive T-Lymphocytes; Cell Line; Cell Survival; Cytopathogenic Effect, Viral; Fixatives; Flow Cytometry; Fluoresceins; HIV; Humans; Leukocyte Count; Zidovudine | 1988 |
Drug-resistant strains of AIDS virus found.
Topics: Acquired Immunodeficiency Syndrome; Drug Resistance, Microbial; HIV; Humans; Zidovudine | 1989 |
5-Chloro-substituted derivatives of 2', 3'-didehydro-2',3'-dideoxyuridine, 3'-fluoro-2',3'-dideoxyuridine and 3'-azido-2',3'-dideoxyuridine as anti-HIV agents.
Topics: Animals; Antiviral Agents; Cell Line; Dideoxynucleosides; HIV; Humans; Kinetics; Thymidine Kinase; Virus Replication; Zidovudine | 1989 |
AIDS: the virus, antivirals and vaccines.
Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Foscarnet; Genes, Viral; HIV; Humans; Phosphonoacetic Acid; Suramin; Thymidine; Tungsten; Tungsten Compounds; Viral Vaccines; Virus Replication; Zidovudine | 1987 |
Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.
Topics: Antigens, Viral; Antiviral Agents; Cell Line; Cell Survival; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Stavudine; Structure-Activity Relationship; Thymidine; Virus Replication; Zidovudine | 1987 |
Antiviral activity of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2',3'-didehydrocytidine) against human immunodeficiency virus in vitro.
Topics: Antiviral Agents; Deoxycytidine; Fluorescence; HIV; Humans; In Vitro Techniques; Monocytes; Thymidine; Zalcitabine; Zidovudine | 1987 |
Substances affecting the infection and replication of human immunodeficiency virus (HIV).
Topics: Cell Line; Cytopathogenic Effect, Viral; Deltaretrovirus; Dinoprostone; HIV; Humans; Interferon-gamma; Prostaglandins E; Tetradecanoylphorbol Acetate; Thymidine; Tretinoin; Virus Replication; Zidovudine | 1986 |
Inhibitory effect of 2',3'-didehydro-2',3'-dideoxynucleosides on infectivity, cytopathic effects, and replication of human immunodeficiency virus.
Topics: Antigens, Viral; Antiviral Agents; Cells, Cultured; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Stavudine; Thymidine; Viral Plaque Assay; Virus Replication; Zalcitabine; Zidovudine | 1987 |
Effect of 3'-azido-2',3'-dideoxythymidine (AZT) and neutralizing antibody on human immunodeficiency virus (HIV)-induced cytopathic effects: implication of giant cell formation for the spread of virus in vivo.
Topics: Antibodies, Viral; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Antiviral Agents; Cell Fusion; Cytopathogenic Effect, Viral; HIV; Neutralization Tests; T-Lymphocytes; Thymidine; Virus Replication; Zidovudine | 1987 |
Suppression of human immunodeficiency virus replication by 3'-azido-3'-deoxythymidine in various human hematopoietic cell lines in vitro: augmentation of the effect by lentinan.
Topics: Cell Line; Drug Synergism; Hematopoietic Stem Cells; HIV; Humans; Lentinan; Polysaccharides; T-Lymphocytes; Thymidine; Virus Replication; Zidovudine | 1987 |
Amplification of human immuno-deficiency virus production from a virus-producing cell line in culture at high cell density.
Topics: Cell Line; Culture Media; Electrophoresis, Polyacrylamide Gel; HIV; Humans; Membrane Proteins; Thymidine; Viral Proteins; Virion; Virology; Virus Replication; Zidovudine | 1987 |
Suppression by neurotropin of production of human immuno-deficiency virus by the virus-producing MOLT-4 cell line.
Topics: Acquired Immunodeficiency Syndrome; Antigens, Surface; Antigens, Viral; Cell Line; HIV; Humans; Polysaccharides; Thymidine; Virion; Virus Replication; Zidovudine | 1987 |
Decline of HIV antigen levels in cerebrospinal fluid during treatment with low-dose zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Antigens, Viral; Central Nervous System Diseases; HIV; HIV Antigens; Humans; Male; Thymidine; Time Factors; Virus Replication; Zidovudine | 1988 |
HIV antigenemia and zidovudine.
Topics: Antigens, Viral; Antiviral Agents; HIV; HIV Antigens; Humans; Thymidine; Zidovudine | 1988 |
[HIV infection and AIDS. Paris, 25-29 January 1988].
Topics: Acquired Immunodeficiency Syndrome; Antibody Formation; HIV; Humans; Thymidine; Zidovudine | 1988 |
[Zidovudin (Retrovir). A new antiviral agents against human immunodeficiency viruses (HIV)].
Topics: Antiviral Agents; Chemical Phenomena; Chemistry; HIV; Thymidine; Zidovudine | 1988 |
The effect of zidovudine on antigen levels in HIV infection.
Topics: Acyclovir; Antigens, Viral; Antiviral Agents; Drug Therapy, Combination; HIV; HIV Antigens; HIV Seropositivity; Humans; Male; Thymidine; Zidovudine | 1988 |
Phosphorylation, anti-HIV activity and cytotoxicity of 3'-fluorothymidine.
Topics: Animals; Antiviral Agents; Cell Division; Cell Line; Cell Survival; Cytidine Diphosphate; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Mice; Phosphorylation; Rats; Thymidine; Virus Replication; Zidovudine | 1988 |
AIDS dementia: synthesis and properties of a derivative of 3'-azido-3'-deoxythymidine (AZT) that may become 'locked' in the central nervous system.
Topics: Acquired Immunodeficiency Syndrome; Animals; Brain; Cell Line; Chemical Phenomena; Chemistry; Dementia; Dihydropyridines; HIV; Humans; Male; Mice; Moloney murine sarcoma virus; Pharmaceutical Preparations; Prodrugs; Rats; Rats, Inbred Strains; Thymidine; Virus Replication; Zidovudine | 1988 |
[AIDS also an experimental problem. Selection of experimental animals is difficult--no new therapeutic approaches in view].
Topics: Acquired Immunodeficiency Syndrome; Animals; Disease Models, Animal; HIV; Macaca fascicularis; Zidovudine | 1988 |
In vitro effectiveness of a combination of zidovudine and ansamycin against human immunodeficiency virus.
Topics: Anti-Bacterial Agents; Drug Interactions; HIV; Humans; Lactams, Macrocyclic; Zidovudine | 1988 |
Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity.
Topics: Antiviral Agents; Cytidine; HIV; Humans; In Vitro Techniques; Macrophages; Stem Cells; Thymidine; Uridine; Virus Replication; Zidovudine | 1988 |
Significant changes in HIV antigen level in the serum of patients treated with azidothymidine.
Topics: Acquired Immunodeficiency Syndrome; Antigens, Viral; Antiviral Agents; HIV; HIV Antigens; Humans; Thymidine; Zidovudine | 1986 |
Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon.
Topics: Antiviral Agents; Drug Synergism; HIV; Humans; Interferon Type I; Recombinant Proteins; Thymidine; Virus Replication; Zidovudine | 1987 |
Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV (HTLV-III/LAV)].
Topics: Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; Drug Interactions; Glycyrrhetinic Acid; Glycyrrhizic Acid; HIV; Humans; Thymidine; Zidovudine | 1987 |
Azidothymidine (AZT).
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; HIV; Humans; Thymidine; Zidovudine | 1987 |
Transmission of HIV by antigen presenting cells during T-cell activation: prevention by 3'-azido-3'-deoxythymidine.
Topics: Antigen-Presenting Cells; Antiviral Agents; Cell Line; Cell Survival; HIV; Humans; Lymphocyte Activation; Models, Biological; Radioimmunoassay; T-Lymphocytes; Tetanus Toxoid; Thymidine; Zidovudine | 1987 |
Dideoxynucleosides are less inhibitory in vitro against human immunodeficiency virus type 2 (HIV-2) than against HIV-1.
Topics: Antiviral Agents; Cell Line; Drug Resistance, Microbial; HIV; Humans; T-Lymphocytes; Thymidine; Virus Replication; Zidovudine | 1987 |
The AIDS virus.
Topics: Acquired Immunodeficiency Syndrome; Animals; Chlorocebus aethiops; Genes, Viral; History, 20th Century; HIV; Humans; Lymphocytes; Thymidine; Viral Envelope Proteins; Viral Vaccines; Zidovudine | 1987 |
Antibacterial activity and mechanism of action of 3'-azido-3'-deoxythymidine (BW A509U).
Topics: Antiviral Agents; DNA Replication; DNA, Bacterial; Drug Resistance, Microbial; Enterobacteriaceae; Escherichia coli; HIV; Kinetics; Microbial Sensitivity Tests; Mutation; Thymidine; Thymidine Kinase; Vibrio; Zidovudine | 1987 |