Page last updated: 2024-10-21

xanthine and Syndrome

xanthine has been researched along with Syndrome in 1 studies

7H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-7 is protonated.
9H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated.

Syndrome: A characteristic symptom complex.

Research

Studies (1)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Thomassen, A	1
Nielsen, TT	1
Bagger, JP	1
Pedersen, AK	1
Henningsen, P	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Phase III Study of Intravenous Glutamate Infusion for Metabolic Protection of the Heart in Surgery for Unstable Coronary Artery Disease[NCT00489827]			Phase 3	865 participants (Actual)	Interventional	2005-10-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Atrial Fibrillation

Number of patients with atrial fibrillation recorded postoperatively (NCT00489827)
Timeframe: Hospital stay

Intervention	Participants (Count of Participants)
Intravenous Glutamate	147
Saline Infusion	152

ICU Stay

ICU duration of stay (hours) (NCT00489827)
Timeframe: ICU stay

Intervention	hours (Median)
Intravenous Glutamate	21
Saline Infusion	21

Number of Participants With Perioperative Myocardial Infarction, Postoperative Heart Failure or Postoperative Mortality

(NCT00489827)
Timeframe: 30 days

Intervention	Participants (Count of Participants)
Intravenous Glutamate	31
Saline Infusion	25

Number of Participants With Postoperative Stroke < 24 Hours

Incidence of Postoperative stroke < 24 hours of surgery verifed by CT-scan (NCT00489827)
Timeframe: 24 hours

Intervention	Participants (Count of Participants)
Intravenous Glutamate	4
Saline Infusion	6

Postoperative Hemodynamic State in Patients With Severely Reduced Left Ventricular Ejection Fraction (LVEF<0.40)

Hemodynamic instability despite inotropes or need for IABP at the end of surgery in patients with severely reduced left ventricular ejection fraction (LVEF<0.40) (NCT00489827)
Timeframe: End of surgery

Intervention	Participants (Count of Participants)
Intravenous Glutamate	1
Saline Infusion	5

Postoperative Renal Function

maximum p-creatinine value recorded postoperatively < 30 days (NCT00489827)
Timeframe: 30 days

Intervention	µmol/L (Mean)
Intravenous Glutamate	106
Saline Infusion	106

Severe Circulatory Failure in CCS Class IV Patients

Severe circulatory failure according to prespecified criteria as judged by a blinded endpoints committee in CCS class IV patients (NCT00489827)
Timeframe: 30 days

Intervention	Participants (Count of Participants)
Intravenous Glutamate	3
Saline Infusion	16

Degree of Perioperative Myocardial Injury

p-CK-MB postoperative day 1, p-troponin-T postoperative day 3 (NCT00489827)
Timeframe: perioperative

Intervention	µg/L (Median)
	CK-MB day 1	Troponin-T day 3
Intravenous Glutamate	14	0.27
Saline Infusion	14	0.24

Postoperative Hemodynamic State

Mixed venous oxygen saturation (SvO2) measured at weaning from cardiopulmonary bypass and on arrival to ICU (NCT00489827)
Timeframe: Until arrival to ICU

Intervention	percentage of saturated hemoglobin (Mean)
	SvO2 at weaning from CPB	SvO2 on arrival to ICU
Intravenous Glutamate	72.0	65.0
Saline Infusion	72.2	64.9

Other Studies

1 other study available for xanthine and Syndrome

Article	Year
Antiischemic and metabolic effects of glutamate during pacing in patients with stable angina pectoris secondary to either coronary artery disease or syndrome X. The American journal of cardiology, 1991, Aug-01, Volume: 68, Issue:4 Topics: Adult; Angina Pectoris; Cardiac Pacing, Artificial; Coronary Angiography; Coronary Disease; Electroc	1991