xanthine and Aging
xanthine has been researched along with Aging in 11 studies
7H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-7 is protonated.
9H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Adenosine is a neuromodulator that has been involved in aging and neurodegenerative diseases as Alzheimer's disease (AD)." | 7.96 | Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging. ( Albasanz, JL; Martín, M; Pallàs, M; Sánchez-Melgar, A, 2020) |
| "Free uric acid concentrations declined with aging in male Oregon R Drosophila melanogaster by 59% or more between 0 and 50 days of adult age." | 7.68 | Uric acid content of Drosophila decreases with aging. ( Massie, HR; Shumway, ME; Whitney, SJ, 1991) |
| "In order to explain features of severe hypoxanthine guanine phosphoribosyltransferase (HPRT) deficiency, the Lesch-Nyhan syndrome, a continuous supply of substrate, hypoxanthine, for the enzyme must be generated." | 7.68 | The pathogenesis of the Lesch-Nyhan syndrome: ATP use is positively related to hypoxanthine supply to hypoxanthine guanine phosphoribosyltransferase. ( Greenwood, R; Harkness, RA; McCreanor, GM, 1991) |
| "Allantoin is a nonenzymatic oxidative product of uric acid in human." | 5.32 | Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms? ( Aruoma, OI; Duracková, Z; Garaiová, I; Kalnovicová, T; Korytár, P; Muchová, J; Pueschel, S; Sustrová, M; Zitnanová, I, 2004) |
| "Adenosine is a neuromodulator that has been involved in aging and neurodegenerative diseases as Alzheimer's disease (AD)." | 3.96 | Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging. ( Albasanz, JL; Martín, M; Pallàs, M; Sánchez-Melgar, A, 2020) |
| "Aging is a factor known to increase neuronal vulnerability to oxidative stress, which is widely accepted as a mechanism of manganese-induced neuronal damage." | 3.70 | Glutathione deficiency potentiates manganese-induced increases in compounds associated with high-energy phosphate degradation in discrete brain areas of young and aged rats. ( Delogu, MR; Desole, MS; Esposito, G; Fresu, L; Miele, M; Migheli, R; Rocchitta, G; Serra, PA, 2000) |
| " Here, we studied peripheral blood mononuclear cells (PBMC) from male rhesus monkeys to investigate the following: 1) the production of IL-6 and other cytokines become dysregulated with aging; 2) ER influences cytokine production and mRNA expression; and, 3) oxidative stress, as induced in vitro by xanthine and xanthine oxidase (X/XOD), influences cytokine mRNA and protein levels." | 3.69 | Adult-onset energy restriction of rhesus monkeys attenuates oxidative stress-induced cytokine expression by peripheral blood mononuclear cells. ( Aiken, JM; Havighurst, T; Hollander, J; Kim, MJ; Ripple, MO; Weindruch, R, 1997) |
| "Free uric acid concentrations declined with aging in male Oregon R Drosophila melanogaster by 59% or more between 0 and 50 days of adult age." | 3.68 | Uric acid content of Drosophila decreases with aging. ( Massie, HR; Shumway, ME; Whitney, SJ, 1991) |
| "In order to explain features of severe hypoxanthine guanine phosphoribosyltransferase (HPRT) deficiency, the Lesch-Nyhan syndrome, a continuous supply of substrate, hypoxanthine, for the enzyme must be generated." | 3.68 | The pathogenesis of the Lesch-Nyhan syndrome: ATP use is positively related to hypoxanthine supply to hypoxanthine guanine phosphoribosyltransferase. ( Greenwood, R; Harkness, RA; McCreanor, GM, 1991) |
| "Allantoin is a nonenzymatic oxidative product of uric acid in human." | 1.32 | Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms? ( Aruoma, OI; Duracková, Z; Garaiová, I; Kalnovicová, T; Korytár, P; Muchová, J; Pueschel, S; Sustrová, M; Zitnanová, I, 2004) |
Research
Studies (11)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Sánchez-Melgar, A | 1 |
| Albasanz, JL | 1 |
| Pallàs, M | 1 |
| Martín, M | 1 |
| Ryan, MJ | 1 |
| Jackson, JR | 1 |
| Hao, Y | 1 |
| Leonard, SS | 1 |
| Alway, SE | 1 |
| Zitnanová, I | 1 |
| Korytár, P | 1 |
| Aruoma, OI | 1 |
| Sustrová, M | 1 |
| Garaiová, I | 1 |
| Muchová, J | 1 |
| Kalnovicová, T | 1 |
| Pueschel, S | 1 |
| Duracková, Z | 1 |
| Kim, MJ | 1 |
| Aiken, JM | 1 |
| Havighurst, T | 1 |
| Hollander, J | 1 |
| Ripple, MO | 1 |
| Weindruch, R | 1 |
| Kakino, J | 1 |
| Sato, R | 1 |
| Naito, Y | 1 |
| Pahlavani, MA | 1 |
| Harris, MD | 1 |
| Miele, M | 2 |
| Serra, PA | 2 |
| Esposito, G | 2 |
| Delogu, MR | 2 |
| Migheli, R | 2 |
| Rocchitta, G | 2 |
| Desole, MS | 2 |
| Fresu, L | 1 |
| Massie, HR | 1 |
| Shumway, ME | 1 |
| Whitney, SJ | 1 |
| Harkness, RA | 1 |
| McCreanor, GM | 1 |
| Greenwood, R | 1 |
| Schröder, HC | 1 |
| Messer, R | 1 |
| Bachmann, M | 1 |
| Bernd, A | 1 |
| Müller, WE | 1 |
Other Studies
11 other studies available for xanthine and Aging
| Article | Year |
|---|---|
Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging.
Topics: Adenosine; Aging; Alzheimer Disease; Animals; Cellular Senescence; Cerebral Cortex; Disease Models, | 2020 |
Inhibition of xanthine oxidase reduces oxidative stress and improves skeletal muscle function in response to electrically stimulated isometric contractions in aged mice.
Topics: Age Factors; Aging; Allopurinol; Animals; Apoptosis; Caspase 3; Catalase; Electric Stimulation; Glut | 2011 |
Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms?
Topics: Adolescent; Aging; Allantoin; Antioxidants; Child; Chromatography, High Pressure Liquid; Down Syndro | 2004 |
Adult-onset energy restriction of rhesus monkeys attenuates oxidative stress-induced cytokine expression by peripheral blood mononuclear cells.
Topics: Aging; Animals; Energy Intake; Interleukin-6; Interleukins; Leukocytes, Mononuclear; Macaca mulatta; | 1997 |
Purine metabolism of uric acid urolithiasis induced in newborn piglets.
Topics: Aging; Allantoin; Animals; Animals, Newborn; Body Weight; Hypoxanthine; Purines; Swine; Swine Diseas | 1998 |
Effect of in vitro generation of oxygen free radicals on T cell function in young and old rats.
Topics: Aging; Animals; Antioxidants; Cells, Cultured; Concanavalin A; Free Radicals; Hot Temperature; Hydro | 1998 |
Glutamate and catabolites of high-energy phosphates in the striatum and brainstem of young and aged rats subchronically exposed to manganese.
Topics: Aging; Animals; Brain Stem; Corpus Striatum; Energy Metabolism; Glutamic Acid; Hypoxanthine; Male; M | 2000 |
Glutathione deficiency potentiates manganese-induced increases in compounds associated with high-energy phosphate degradation in discrete brain areas of young and aged rats.
Topics: Aging; Animals; Antimetabolites; Ascorbic Acid; Brain; Buthionine Sulfoximine; Dehydroascorbic Acid; | 2000 |
Uric acid content of Drosophila decreases with aging.
Topics: Aging; Animals; Drosophila melanogaster; Male; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1991 |
The pathogenesis of the Lesch-Nyhan syndrome: ATP use is positively related to hypoxanthine supply to hypoxanthine guanine phosphoribosyltransferase.
Topics: Adenosine Triphosphate; Adult; Aging; Body Mass Index; Creatinine; Exercise; Female; Humans; Hypoxan | 1991 |
Superoxide radical-induced loss of nuclear restriction of immature mRNA: a possible cause for ageing.
Topics: Adenosine Triphosphate; Aging; Animals; Biological Transport; Cell Nucleus; Chickens; Female; Free R | 1987 |