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xanthine and Aging

xanthine has been researched along with Aging in 11 studies

7H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-7 is protonated.
9H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Adenosine is a neuromodulator that has been involved in aging and neurodegenerative diseases as Alzheimer's disease (AD)."7.96Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging. ( Albasanz, JL; Martín, M; Pallàs, M; Sánchez-Melgar, A, 2020)
"Free uric acid concentrations declined with aging in male Oregon R Drosophila melanogaster by 59% or more between 0 and 50 days of adult age."7.68Uric acid content of Drosophila decreases with aging. ( Massie, HR; Shumway, ME; Whitney, SJ, 1991)
"In order to explain features of severe hypoxanthine guanine phosphoribosyltransferase (HPRT) deficiency, the Lesch-Nyhan syndrome, a continuous supply of substrate, hypoxanthine, for the enzyme must be generated."7.68The pathogenesis of the Lesch-Nyhan syndrome: ATP use is positively related to hypoxanthine supply to hypoxanthine guanine phosphoribosyltransferase. ( Greenwood, R; Harkness, RA; McCreanor, GM, 1991)
"Allantoin is a nonenzymatic oxidative product of uric acid in human."5.32Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms? ( Aruoma, OI; Duracková, Z; Garaiová, I; Kalnovicová, T; Korytár, P; Muchová, J; Pueschel, S; Sustrová, M; Zitnanová, I, 2004)
"Adenosine is a neuromodulator that has been involved in aging and neurodegenerative diseases as Alzheimer's disease (AD)."3.96Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging. ( Albasanz, JL; Martín, M; Pallàs, M; Sánchez-Melgar, A, 2020)
"Aging is a factor known to increase neuronal vulnerability to oxidative stress, which is widely accepted as a mechanism of manganese-induced neuronal damage."3.70Glutathione deficiency potentiates manganese-induced increases in compounds associated with high-energy phosphate degradation in discrete brain areas of young and aged rats. ( Delogu, MR; Desole, MS; Esposito, G; Fresu, L; Miele, M; Migheli, R; Rocchitta, G; Serra, PA, 2000)
" Here, we studied peripheral blood mononuclear cells (PBMC) from male rhesus monkeys to investigate the following: 1) the production of IL-6 and other cytokines become dysregulated with aging; 2) ER influences cytokine production and mRNA expression; and, 3) oxidative stress, as induced in vitro by xanthine and xanthine oxidase (X/XOD), influences cytokine mRNA and protein levels."3.69Adult-onset energy restriction of rhesus monkeys attenuates oxidative stress-induced cytokine expression by peripheral blood mononuclear cells. ( Aiken, JM; Havighurst, T; Hollander, J; Kim, MJ; Ripple, MO; Weindruch, R, 1997)
"Free uric acid concentrations declined with aging in male Oregon R Drosophila melanogaster by 59% or more between 0 and 50 days of adult age."3.68Uric acid content of Drosophila decreases with aging. ( Massie, HR; Shumway, ME; Whitney, SJ, 1991)
"In order to explain features of severe hypoxanthine guanine phosphoribosyltransferase (HPRT) deficiency, the Lesch-Nyhan syndrome, a continuous supply of substrate, hypoxanthine, for the enzyme must be generated."3.68The pathogenesis of the Lesch-Nyhan syndrome: ATP use is positively related to hypoxanthine supply to hypoxanthine guanine phosphoribosyltransferase. ( Greenwood, R; Harkness, RA; McCreanor, GM, 1991)
"Allantoin is a nonenzymatic oxidative product of uric acid in human."1.32Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms? ( Aruoma, OI; Duracková, Z; Garaiová, I; Kalnovicová, T; Korytár, P; Muchová, J; Pueschel, S; Sustrová, M; Zitnanová, I, 2004)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19901 (9.09)18.7374
1990's5 (45.45)18.2507
2000's3 (27.27)29.6817
2010's1 (9.09)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Sánchez-Melgar, A1
Albasanz, JL1
Pallàs, M1
Martín, M1
Ryan, MJ1
Jackson, JR1
Hao, Y1
Leonard, SS1
Alway, SE1
Zitnanová, I1
Korytár, P1
Aruoma, OI1
Sustrová, M1
Garaiová, I1
Muchová, J1
Kalnovicová, T1
Pueschel, S1
Duracková, Z1
Kim, MJ1
Aiken, JM1
Havighurst, T1
Hollander, J1
Ripple, MO1
Weindruch, R1
Kakino, J1
Sato, R1
Naito, Y1
Pahlavani, MA1
Harris, MD1
Miele, M2
Serra, PA2
Esposito, G2
Delogu, MR2
Migheli, R2
Rocchitta, G2
Desole, MS2
Fresu, L1
Massie, HR1
Shumway, ME1
Whitney, SJ1
Harkness, RA1
McCreanor, GM1
Greenwood, R1
Schröder, HC1
Messer, R1
Bachmann, M1
Bernd, A1
Müller, WE1

Other Studies

11 other studies available for xanthine and Aging

ArticleYear
Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging.
    International journal of molecular sciences, 2020, Oct-02, Volume: 21, Issue:19

    Topics: Adenosine; Aging; Alzheimer Disease; Animals; Cellular Senescence; Cerebral Cortex; Disease Models,

2020
Inhibition of xanthine oxidase reduces oxidative stress and improves skeletal muscle function in response to electrically stimulated isometric contractions in aged mice.
    Free radical biology & medicine, 2011, Jul-01, Volume: 51, Issue:1

    Topics: Age Factors; Aging; Allopurinol; Animals; Apoptosis; Caspase 3; Catalase; Electric Stimulation; Glut

2011
Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms?
    Clinica chimica acta; international journal of clinical chemistry, 2004, Volume: 341, Issue:1-2

    Topics: Adolescent; Aging; Allantoin; Antioxidants; Child; Chromatography, High Pressure Liquid; Down Syndro

2004
Adult-onset energy restriction of rhesus monkeys attenuates oxidative stress-induced cytokine expression by peripheral blood mononuclear cells.
    The Journal of nutrition, 1997, Volume: 127, Issue:12

    Topics: Aging; Animals; Energy Intake; Interleukin-6; Interleukins; Leukocytes, Mononuclear; Macaca mulatta;

1997
Purine metabolism of uric acid urolithiasis induced in newborn piglets.
    The Journal of veterinary medical science, 1998, Volume: 60, Issue:2

    Topics: Aging; Allantoin; Animals; Animals, Newborn; Body Weight; Hypoxanthine; Purines; Swine; Swine Diseas

1998
Effect of in vitro generation of oxygen free radicals on T cell function in young and old rats.
    Free radical biology & medicine, 1998, Nov-15, Volume: 25, Issue:8

    Topics: Aging; Animals; Antioxidants; Cells, Cultured; Concanavalin A; Free Radicals; Hot Temperature; Hydro

1998
Glutamate and catabolites of high-energy phosphates in the striatum and brainstem of young and aged rats subchronically exposed to manganese.
    Aging (Milan, Italy), 2000, Volume: 12, Issue:5

    Topics: Aging; Animals; Brain Stem; Corpus Striatum; Energy Metabolism; Glutamic Acid; Hypoxanthine; Male; M

2000
Glutathione deficiency potentiates manganese-induced increases in compounds associated with high-energy phosphate degradation in discrete brain areas of young and aged rats.
    Aging (Milan, Italy), 2000, Volume: 12, Issue:6

    Topics: Aging; Animals; Antimetabolites; Ascorbic Acid; Brain; Buthionine Sulfoximine; Dehydroascorbic Acid;

2000
Uric acid content of Drosophila decreases with aging.
    Experimental gerontology, 1991, Volume: 26, Issue:6

    Topics: Aging; Animals; Drosophila melanogaster; Male; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines

1991
The pathogenesis of the Lesch-Nyhan syndrome: ATP use is positively related to hypoxanthine supply to hypoxanthine guanine phosphoribosyltransferase.
    Journal of inherited metabolic disease, 1991, Volume: 14, Issue:2

    Topics: Adenosine Triphosphate; Adult; Aging; Body Mass Index; Creatinine; Exercise; Female; Humans; Hypoxan

1991
Superoxide radical-induced loss of nuclear restriction of immature mRNA: a possible cause for ageing.
    Mechanisms of ageing and development, 1987, Volume: 41, Issue:3

    Topics: Adenosine Triphosphate; Aging; Animals; Biological Transport; Cell Nucleus; Chickens; Female; Free R

1987