xanthine has been researched along with Aging in 11 studies
7H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-7 is protonated.
9H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Excerpt | Relevance | Reference |
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"Adenosine is a neuromodulator that has been involved in aging and neurodegenerative diseases as Alzheimer's disease (AD)." | 7.96 | Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging. ( Albasanz, JL; Martín, M; Pallàs, M; Sánchez-Melgar, A, 2020) |
"Free uric acid concentrations declined with aging in male Oregon R Drosophila melanogaster by 59% or more between 0 and 50 days of adult age." | 7.68 | Uric acid content of Drosophila decreases with aging. ( Massie, HR; Shumway, ME; Whitney, SJ, 1991) |
"In order to explain features of severe hypoxanthine guanine phosphoribosyltransferase (HPRT) deficiency, the Lesch-Nyhan syndrome, a continuous supply of substrate, hypoxanthine, for the enzyme must be generated." | 7.68 | The pathogenesis of the Lesch-Nyhan syndrome: ATP use is positively related to hypoxanthine supply to hypoxanthine guanine phosphoribosyltransferase. ( Greenwood, R; Harkness, RA; McCreanor, GM, 1991) |
"Allantoin is a nonenzymatic oxidative product of uric acid in human." | 5.32 | Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms? ( Aruoma, OI; Duracková, Z; Garaiová, I; Kalnovicová, T; Korytár, P; Muchová, J; Pueschel, S; Sustrová, M; Zitnanová, I, 2004) |
"Adenosine is a neuromodulator that has been involved in aging and neurodegenerative diseases as Alzheimer's disease (AD)." | 3.96 | Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging. ( Albasanz, JL; Martín, M; Pallàs, M; Sánchez-Melgar, A, 2020) |
"Aging is a factor known to increase neuronal vulnerability to oxidative stress, which is widely accepted as a mechanism of manganese-induced neuronal damage." | 3.70 | Glutathione deficiency potentiates manganese-induced increases in compounds associated with high-energy phosphate degradation in discrete brain areas of young and aged rats. ( Delogu, MR; Desole, MS; Esposito, G; Fresu, L; Miele, M; Migheli, R; Rocchitta, G; Serra, PA, 2000) |
" Here, we studied peripheral blood mononuclear cells (PBMC) from male rhesus monkeys to investigate the following: 1) the production of IL-6 and other cytokines become dysregulated with aging; 2) ER influences cytokine production and mRNA expression; and, 3) oxidative stress, as induced in vitro by xanthine and xanthine oxidase (X/XOD), influences cytokine mRNA and protein levels." | 3.69 | Adult-onset energy restriction of rhesus monkeys attenuates oxidative stress-induced cytokine expression by peripheral blood mononuclear cells. ( Aiken, JM; Havighurst, T; Hollander, J; Kim, MJ; Ripple, MO; Weindruch, R, 1997) |
"Free uric acid concentrations declined with aging in male Oregon R Drosophila melanogaster by 59% or more between 0 and 50 days of adult age." | 3.68 | Uric acid content of Drosophila decreases with aging. ( Massie, HR; Shumway, ME; Whitney, SJ, 1991) |
"In order to explain features of severe hypoxanthine guanine phosphoribosyltransferase (HPRT) deficiency, the Lesch-Nyhan syndrome, a continuous supply of substrate, hypoxanthine, for the enzyme must be generated." | 3.68 | The pathogenesis of the Lesch-Nyhan syndrome: ATP use is positively related to hypoxanthine supply to hypoxanthine guanine phosphoribosyltransferase. ( Greenwood, R; Harkness, RA; McCreanor, GM, 1991) |
"Allantoin is a nonenzymatic oxidative product of uric acid in human." | 1.32 | Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms? ( Aruoma, OI; Duracková, Z; Garaiová, I; Kalnovicová, T; Korytár, P; Muchová, J; Pueschel, S; Sustrová, M; Zitnanová, I, 2004) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (9.09) | 18.7374 |
1990's | 5 (45.45) | 18.2507 |
2000's | 3 (27.27) | 29.6817 |
2010's | 1 (9.09) | 24.3611 |
2020's | 1 (9.09) | 2.80 |
Authors | Studies |
---|---|
Sánchez-Melgar, A | 1 |
Albasanz, JL | 1 |
Pallàs, M | 1 |
Martín, M | 1 |
Ryan, MJ | 1 |
Jackson, JR | 1 |
Hao, Y | 1 |
Leonard, SS | 1 |
Alway, SE | 1 |
Zitnanová, I | 1 |
Korytár, P | 1 |
Aruoma, OI | 1 |
Sustrová, M | 1 |
Garaiová, I | 1 |
Muchová, J | 1 |
Kalnovicová, T | 1 |
Pueschel, S | 1 |
Duracková, Z | 1 |
Kim, MJ | 1 |
Aiken, JM | 1 |
Havighurst, T | 1 |
Hollander, J | 1 |
Ripple, MO | 1 |
Weindruch, R | 1 |
Kakino, J | 1 |
Sato, R | 1 |
Naito, Y | 1 |
Pahlavani, MA | 1 |
Harris, MD | 1 |
Miele, M | 2 |
Serra, PA | 2 |
Esposito, G | 2 |
Delogu, MR | 2 |
Migheli, R | 2 |
Rocchitta, G | 2 |
Desole, MS | 2 |
Fresu, L | 1 |
Massie, HR | 1 |
Shumway, ME | 1 |
Whitney, SJ | 1 |
Harkness, RA | 1 |
McCreanor, GM | 1 |
Greenwood, R | 1 |
Schröder, HC | 1 |
Messer, R | 1 |
Bachmann, M | 1 |
Bernd, A | 1 |
Müller, WE | 1 |
11 other studies available for xanthine and Aging
Article | Year |
---|---|
Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging.
Topics: Adenosine; Aging; Alzheimer Disease; Animals; Cellular Senescence; Cerebral Cortex; Disease Models, | 2020 |
Inhibition of xanthine oxidase reduces oxidative stress and improves skeletal muscle function in response to electrically stimulated isometric contractions in aged mice.
Topics: Age Factors; Aging; Allopurinol; Animals; Apoptosis; Caspase 3; Catalase; Electric Stimulation; Glut | 2011 |
Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms?
Topics: Adolescent; Aging; Allantoin; Antioxidants; Child; Chromatography, High Pressure Liquid; Down Syndro | 2004 |
Adult-onset energy restriction of rhesus monkeys attenuates oxidative stress-induced cytokine expression by peripheral blood mononuclear cells.
Topics: Aging; Animals; Energy Intake; Interleukin-6; Interleukins; Leukocytes, Mononuclear; Macaca mulatta; | 1997 |
Purine metabolism of uric acid urolithiasis induced in newborn piglets.
Topics: Aging; Allantoin; Animals; Animals, Newborn; Body Weight; Hypoxanthine; Purines; Swine; Swine Diseas | 1998 |
Effect of in vitro generation of oxygen free radicals on T cell function in young and old rats.
Topics: Aging; Animals; Antioxidants; Cells, Cultured; Concanavalin A; Free Radicals; Hot Temperature; Hydro | 1998 |
Glutamate and catabolites of high-energy phosphates in the striatum and brainstem of young and aged rats subchronically exposed to manganese.
Topics: Aging; Animals; Brain Stem; Corpus Striatum; Energy Metabolism; Glutamic Acid; Hypoxanthine; Male; M | 2000 |
Glutathione deficiency potentiates manganese-induced increases in compounds associated with high-energy phosphate degradation in discrete brain areas of young and aged rats.
Topics: Aging; Animals; Antimetabolites; Ascorbic Acid; Brain; Buthionine Sulfoximine; Dehydroascorbic Acid; | 2000 |
Uric acid content of Drosophila decreases with aging.
Topics: Aging; Animals; Drosophila melanogaster; Male; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1991 |
The pathogenesis of the Lesch-Nyhan syndrome: ATP use is positively related to hypoxanthine supply to hypoxanthine guanine phosphoribosyltransferase.
Topics: Adenosine Triphosphate; Adult; Aging; Body Mass Index; Creatinine; Exercise; Female; Humans; Hypoxan | 1991 |
Superoxide radical-induced loss of nuclear restriction of immature mRNA: a possible cause for ageing.
Topics: Adenosine Triphosphate; Aging; Animals; Biological Transport; Cell Nucleus; Chickens; Female; Free R | 1987 |