warfarin and Hepatitis-A

Five patients received a small oral dose of warfarin during and after recovery from acute viral hepatitis. Mean (+/- SD) clearance, volume of distribution, and half-life of the drug were 6.1 +/- 0.9 ml/hr/kg, 0.09 +/- 0.04 L/kg, and 23 +/- 5 hr, respectively, during the acute period. After apparent recovery, observed values were 6.1 +/- 0.7 ml/hr/kg, 0.21 +/- 0.02 L/kg, and 25 +/- 3 hr. These differences were not significant. Pattern of renal elimination of warfarin metabolites and drug protein binding did not change between the two phases. During the acute period of illness, prothrombin time increased in 2 of the 5 subjects, but remained within normal limits in all participants during the recovery period. This study shows that warfarin disposition may not change as a consequence of mild or moderate hepatic impairment.

Topics: Adult; Blood Coagulation; Blood Proteins; Half-Life; Hepatitis A; Humans; Kinetics; Male; Protein Binding; Prothrombin Time; Time Factors; Warfarin

Topics: Adult; Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Blood Coagulation Factors; Child; Factor IX; Factor VII; Factor X; Female; Hemophilia B; Hepatitis A; Hepatitis B Antigens; Humans; Liver Diseases; Liver Function Tests; Male; Middle Aged; Poisoning; Prothrombin; Warfarin