vitamin-b-12 and Edema

Third molar extraction is a common procedure frequently accompanied by moderate or severe pain, and involves sufficient numbers of patients to make studies relatively easy to perform. The aim of the present study was to determine the efficacy and safety of the therapeutic combination of 10 mg piroxicam, 1 mg dexamethasone, 35 mg orphenadrine citrate, and 2.5 mg cyanocobalamin (Rheumazin) when compared with 20 mg piroxicam alone (Feldene) in mandibular third molar surgery. Eighty patients scheduled for removal of the third molar were included in this randomized and double-blind study. They received (vo) Rheumazin or Feldene 30 min after tooth extraction and once daily for 4 consecutive days. Pain was determined by a visual analogue scale and by the need for escape analgesia (paracetamol). Facial swelling was evaluated with a measuring tape and adverse effects and patient satisfaction were recorded. There was no statistically significant difference in facial swelling between Rheumazin and Feldene (control group). Both drugs were equally effective in the control of pain, with Rheumazin displaying less adverse effects than Feldene. Therefore, Rheumazin appears to provide a better risk/benefit ratio in the mandibular molar surgery. Since the side effects resulting from nonsteroidal anti-inflammatory drug administration are a severe limitation to the routine use of these drugs in clinical practice, our results suggest that Rheumazin can be a good choice for third molar removal treatment.

Topics: Adolescent; Adult; Anti-Inflammatory Agents; Dexamethasone; Double-Blind Method; Drug Therapy, Combination; Edema; Female; Humans; Male; Middle Aged; Molar, Third; Muscle Relaxants, Central; Orphenadrine; Pain Measurement; Pain, Postoperative; Piroxicam; Prospective Studies; Severity of Illness Index; Tooth Extraction; Vitamin B 12; Vitamin B Complex

Pemetrexed is a novel, multitargeted antifolate approved for the treatment of malignant pleural mesothelioma and non-small cell lung cancer. Although pemetrexed is a safe drug, some adverse effects such as myelosupression and cutaneous reactions are observed. Pemetrexed-induced eyelid edema is a rare side effect of pemetrexed treatment, and until this moment few cases were reported in the medical literature. We reported a new case of pemetrexed-induced eyelid edema in a patient with adenocarcinoma of the lung with brain metastases.

Topics: Adenocarcinoma; Antineoplastic Agents; Brain Neoplasms; Carboplatin; Dexamethasone; Diuretics; Edema; Eyelid Diseases; Female; Folic Acid; Furosemide; Glucocorticoids; Glutamates; Guanine; Humans; Lung Neoplasms; Middle Aged; Pemetrexed; Vitamin B 12

Topics: Breast Feeding; Diet, Vegetarian; Edema; Female; Humans; Infant; Infant Nutritional Physiological Phenomena; Mothers; Vitamin B 12; Vitamin B 12 Deficiency

Approximately 15% of people aged more than 60 years old have a cobalamin (vitamin B12) deficiency, mainly in relation with food-cobalamin malabsorption (FCM). To date, no study has documented this disorder in the elderly. There is also little information on clinical consequences.. We studied 92 elderly patients with well-established FCM who were extracted from an observational cohort study (1995-2004) of 172 consecutive elderly patients with documented cobalamin deficiency.. The median patient age was 76 +/- 8 years; 60 patients were women. The most common clinical manifestations were neurologic or psychologic: mild sensory polyneuropathy (44.6%), confusion or impaired mental functioning (22.8%), and physical asthenia (20.7%). Hematologic abnormalities were reported in at least one third of the patients: anemia (21%), leukopenia (10.9%), thrombopenia (8.7%), and pancytopenia (6.5%). All patients had low serum vitamin B12 levels (<200 pg/mL), with a mean value (+/- standard deviation) of 131 +/- 38 pg/mL and total serum homocysteine level of 22.1 +/- 9.3 micromol/L. The mean hemoglobin level was 10.9 +/- 2.5 g/dL and the mean erythrocyte cell volume 95.7 +/- 12.7 fL. Correction of the serum vitamin B12 levels and hematologic abnormalities was achieved equally well in patients treated with either intramuscular or oral crystalline cyanocobalamin.. This study suggests that in elderly patients, FCM may be associated with significant neurologic, psychologic, and hematologic abnormalities, which seem to respond equally well to either oral or parenteral vitamin B12 therapy.

Topics: Aged; Aged, 80 and over; Asthenia; Cognition Disorders; Cohort Studies; Confusion; Edema; Erythrocyte Indices; Female; Follow-Up Studies; Gastritis, Atrophic; Hematologic Diseases; Hemoglobins; Homocysteine; Humans; Jaundice; Malabsorption Syndromes; Male; Paresthesia; Polyneuropathies; Reflex, Abnormal; Retrospective Studies; Vitamin B 12; Vitamin B 12 Deficiency

The effect of some B vitamins in chemical and thermal models of nociception in mice was investigated. The association thiamine/pyridoxine/cyanocobalamin (TPC, 20-200 mg/kg, i.p. or per os), thiamine, pyridoxine (50-200 mg/kg, i.p.) or riboflavin (3-100 mg/kg, i.p) induced an antinociceptive effect, not changed by naloxone (10 mg/kg, i.p.), in the acetic acid writhing model. Treatment for 7 days with thiamine/pyridoxine/cyanocobalamin (100 or 200 mg/kg, i.p.), thiamine (50 or 100 mg/kg) or pyridoxine (50 or 100 mg/kg) or acute treatment with riboflavin (6 or 12 mg/kg, i.p) inhibited the nociceptive response induced by formaldehyde. The B vitamins did not inhibit the nociceptive response in the hot-plate model. Both 7-day thiamine/pyridoxine/cyanocobalamin (100 mg/kg, i.p.) or acute riboflavin (25 or 50 mg/kg, i.p.) treatment partially reduced formaldehyde-induced hindpaw oedema. The B vitamins antinociceptive effect may involve inhibition of the synthesis and/or action of inflammatory mediators since it was not observed in the hot-plate model, was not reversed by naloxone, only the second phase of the formaldehyde-induced nociceptive response was inhibited, and formaldehyde-induced hindpaw oedema was reduced.

Topics: Acetic Acid; Animals; Constriction; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Formaldehyde; Hindlimb; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Motor Activity; Naloxone; Nociceptors; Pain; Pain Measurement; Pyridoxine; Riboflavin; Thiamine; Vitamin B 12; Vitamin B Complex

In order to get further evidence for a mandatory involvement of epidermal growth factor (EGF) in the neutrophic action of vitamin B12 (cobalamin (Cbl)) in the central nervous system (CNS) of the rat, we observed the effects of repeated intracerebroventricular (ICV) microinjections of EGF in rats made Cbl-deficient through total gastrectomy. Morphometric analysis demonstrated a significant reduction in both intramyelinic and interstitial edema in the white matter of the spinal cord (SC) of totally gastrectomized (TGX) rats after treatment. Intramyelinic and interstitial edema are characteristic of Cbl-deficient central neuropathy in the rat. Similar lesions were also present in SC white matter of rats treated with repeated ICV microinjections of specific anti-EGF antibodies without any modification in their Cbl status. These results, together with those of a previous study showing the cessation of EGF synthesis in the CNS of TGX rats, demonstrate that: a) EGF is necessarily involved in the signaling pathway of Cbl in the rat CNS; and b) the lack of a neurotrophic growth factor EGF, and not the mere withdrawal of Cbl, causes or at least contributes to neurodegenerative Cbl-deficient central neuropathy.

Topics: Animals; Antibodies, Monoclonal; Cerebral Ventricles; Edema; Epidermal Growth Factor; Gastrectomy; Humans; Injections, Intraventricular; Male; Nerve Fibers, Myelinated; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord; Vitamin B 12; Vitamin B 12 Deficiency

Recently several investigations have been reported suggesting that the cause of endolymphatic hydrops might be an immunologic disorder of the endolymphatic space, including the endolymphatic sac. As the first choice in a conservative treatment by medication, the authors have used a combination of prednisolone and furosemide per os, which is rather safe and effective for hydrops patients in a subacute stage. However, some patients do not respond to this treatment or gradually become immune to this medication. With these patients, we have tried an intravenous administration of immunoglobulin G with methyl B12, expecting a curative effect on immunologic deficiency in the endolymphatic space. Compared with a group of patients without this treatment, the group receiving it showed rather good scores in hearing improvement; however, vertigo and tinnitus remained almost unchanged.

Topics: Adult; Aged; Combined Modality Therapy; Drug Resistance; Edema; Endolymphatic Sac; Female; Furosemide; Hearing Loss; Humans; Immunoglobulin G; Injections, Intravenous; Labyrinth Diseases; Male; Meniere Disease; Middle Aged; Prednisolone; Vitamin B 12

The therapeutic efficacy of two neurotrophic substances (exogenic gangliosides and Vitamin B12) is examined in 30 cases of patients suffering from postoperative radiculopathy after the excision of herniated discs. All patients were subjected to clinical examination as well as electromyography and electroneuronography. Check-ups 10 and 60 days after surgery revealed a much greater improvement among the treated than the untreated patients and that statistically significant clinical and electrophysiological improvement was only found among those treated with exogenic gangliosides.

Topics: Adult; Aged; Edema; Electromyography; Female; Gangliosides; Humans; Intervertebral Disc Displacement; Male; Middle Aged; Nerve Compression Syndromes; Vitamin B 12

Topics: Adult; Anemia, Macrocytic; Anemia, Megaloblastic; Edema; Female; Folic Acid; Humans; Lactation; Malabsorption Syndromes; Pregnancy; Pregnancy Complications, Hematologic; Vitamin B 12

Topics: Aminopyrine; Analgesics; Anti-Inflammatory Agents; Dexamethasone; Edema; Humans; Inflammation; Phenylbutazone; Prednisolone; Rheumatic Diseases; Vitamin B 12; Vitamins

Topics: Adolescent; Adult; Anemia, Macrocytic; Atrophy; Biopsy; Bone Marrow Cells; Child; Cobalt Isotopes; Diarrhea; Edema; Female; Folic Acid; Folic Acid Deficiency; Humans; Intestinal Absorption; Intestinal Mucosa; Jejunum; Liver Diseases; Malabsorption Syndromes; Male; Middle Aged; Protein Deficiency; Serum Albumin; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Adult; Anemia, Macrocytic; Calcium; Carotenoids; Celiac Disease; Diarrhea; Edema; Emaciation; Feces; Female; Glutens; Hematocrit; Humans; Immunoglobulins; Intestinal Mucosa; Male; Middle Aged; Pancreatin; Phosphorus; Potassium; Pregnancy; Pregnancy Complications, Hematologic; Prothrombin Time; Serum Albumin; Tetany; Thrombophlebitis; Vitamin B 12; Xylose

Topics: Anemia, Hypochromic; Avitaminosis; Body Weight; Carbohydrate Metabolism; Diarrhea; Disaccharides; Edema; Feces; Folic Acid; Glucose; Humans; Hypocalcemia; Hypokalemia; Hypoproteinemia; Intestinal Absorption; Intestine, Small; Iron; Malabsorption Syndromes; Vitamin A; Vitamin B 12; Vitamin K; Xylose

Topics: Corrinoids; Edema; Female; Humans; Hypertension; Pregnancy; Vitamin B 12; Vitamin B Complex; Vitamins

Topics: Anemia; Edema; Folic Acid; Humans; Iron; Vitamin B 12

Topics: Animals; Choline; Edema; Nutrition Disorders; Protein-Energy Malnutrition; Rats; Research; Vitamin B 12

Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Body Fluids; Child; Corrinoids; Edema; Humans; Hypoalbuminemia; Infant; Serum Albumin; Vitamin B 12

Topics: Corrinoids; Dermatitis, Atopic; Edema; Humans; Vitamin B 12; Vitamin B Complex