Page last updated: 2024-11-05

vigabatrin and Spasm

vigabatrin has been researched along with Spasm in 23 studies

Spasm: An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.

Research Excerpts

ExcerptRelevanceReference
"This systematic review and meta-analysis aimed to evaluate the efficacy of vigabatrin (VGB) in treating infantile epileptic spasms syndrome (IESS)."9.41Efficacy of vigabatrin in the treatment of infantile epileptic spasms syndrome: A systematic review and meta-analysis. ( Chang, X; Gong, P; Jiao, X; Niu, Y; Wu, Y; Xu, Z; Yang, Z; Zhang, Y, 2023)
"To report a prospectively planned analysis of two randomised controlled trials with embedded comparisons of prednisolone versus tetracosactide depot for the treatment of infantile epileptic spasms syndrome (IESS)."8.31Prednisolone or tetracosactide depot for infantile epileptic spasms syndrome? A prospective analysis of data embedded within two randomised controlled trials. ( Alber, FD; Edwards, SW; Hancock, E; Johnson, AL; Kennedy, CR; Likeman, M; Lux, AL; Mackay, M; Mallick, A; Newton, RW; Nolan, M; O'Callaghan, FK; Osborne, JP; Pressler, R; Rating, D; Schmitt, B; Verity, CM, 2023)
"To report response to first treatment in infants with infantile spasms (IS), including incremental benefit of prednisolone 60 mg/day and vigabatrin following prednisolone 40 mg/day failure in infants commenced on the United Kingdom Infantile Spasms Study (UKISS) treatment sequence."8.12Response to sequential treatment with prednisolone and vigabatrin in infantile spasms. ( Cheng, S; Dzau, W; Fahey, M; Harvey, AS; Howell, KB; Scheffer, IE; Snell, P, 2022)
"Vigabatrin (VGB) is approved as monotherapy for pediatric patients with Infantile Spasms (IS)."8.02What is the optimal duration for vigabatrin monotherapy in patients with infantile spasms: 6 months or longer? ( Arbour, M; Bello-Espinosa, L; Birca, A; Bitton, JY; Desnous, B; Lenoir, M; Lortie, A; Mohammed, I; Ronen, GM; Villeneuve, N; Whiting, S; Wirrell, EC, 2021)
"This systematic review and meta-analysis aimed to evaluate the efficacy of vigabatrin (VGB) in treating infantile epileptic spasms syndrome (IESS)."5.41Efficacy of vigabatrin in the treatment of infantile epileptic spasms syndrome: A systematic review and meta-analysis. ( Chang, X; Gong, P; Jiao, X; Niu, Y; Wu, Y; Xu, Z; Yang, Z; Zhang, Y, 2023)
"To describe the temporal trends in the cost and use of adrenocorticotropic hormone (ACTH), oral prednisolone, and vigabatrin, the first-line treatments for infantile epileptic spasms syndrome (IESS)."4.31Temporal trends in the cost and use of first-line treatments for infantile epileptic spasms syndrome. ( Amengual-Gual, M; Barcia Aguilar, C; Chao, J; Douglass, L; Gaínza-Lein, M; Harini, C; Jonas, R; Romeu, A; Sánchez Fernández, I; Sheikh, T; Torres, A, 2023)
"To report a prospectively planned analysis of two randomised controlled trials with embedded comparisons of prednisolone versus tetracosactide depot for the treatment of infantile epileptic spasms syndrome (IESS)."4.31Prednisolone or tetracosactide depot for infantile epileptic spasms syndrome? A prospective analysis of data embedded within two randomised controlled trials. ( Alber, FD; Edwards, SW; Hancock, E; Johnson, AL; Kennedy, CR; Likeman, M; Lux, AL; Mackay, M; Mallick, A; Newton, RW; Nolan, M; O'Callaghan, FK; Osborne, JP; Pressler, R; Rating, D; Schmitt, B; Verity, CM, 2023)
"We evaluated patients with ES from the CDKL5 Centers of Excellence and the National Infantile Spasms Consortium (NISC), with onset from 2 months to 2 years, treated with adrenocorticotropic hormone (ACTH), oral corticosteroids, vigabatrin, and/or the ketogenic diet."4.31Epileptic spasms in CDKL5 deficiency disorder: Delayed treatment and poor response to first-line therapies. ( Benke, T; Daniels, C; DeLeo, M; Demarest, S; Greene, C; Harini, C; Haviland, I; Katyayan, A; Love-Nichols, J; Marsh, ED; Moosa, AN; O'Connor Prange, E; Olson, HE; Pérez-Pérez, JR; Pestana-Knight, E; Poduri, A; Rajaraman, RR; Suter, B; Swanson, L; Weisenberg, J; Zhang, B; Zhang, X, 2023)
"Prednisolone is an effective and well-tolerated medication for treating infantile spasms in Down syndrome."4.12Response to treatment and outcomes of infantile spasms in Down syndrome. ( Allen, NM; Gorman, KM; Harvey, S; King, MD; Lynch, B; Lynch, SA; O'Regan, M; O'Rourke, D; Shahwan, A; Webb, D, 2022)
"To report response to first treatment in infants with infantile spasms (IS), including incremental benefit of prednisolone 60 mg/day and vigabatrin following prednisolone 40 mg/day failure in infants commenced on the United Kingdom Infantile Spasms Study (UKISS) treatment sequence."4.12Response to sequential treatment with prednisolone and vigabatrin in infantile spasms. ( Cheng, S; Dzau, W; Fahey, M; Harvey, AS; Howell, KB; Scheffer, IE; Snell, P, 2022)
"Vigabatrin (VGB) is approved as monotherapy for pediatric patients with Infantile Spasms (IS)."4.02What is the optimal duration for vigabatrin monotherapy in patients with infantile spasms: 6 months or longer? ( Arbour, M; Bello-Espinosa, L; Birca, A; Bitton, JY; Desnous, B; Lenoir, M; Lortie, A; Mohammed, I; Ronen, GM; Villeneuve, N; Whiting, S; Wirrell, EC, 2021)
"To review the result of the infantile spasms' treatment with sodium valproate followed by nitrazepam or clonazepam."3.74Treatment of infantile spasms with sodium valproate followed by benzodiazepines. ( Auvichayapat, N; Auvichayapat, P; Tassniyom, S; Treerotphon, S, 2007)
"The first one is represented by West Syndrome (WS): ES occur in a previously non encephalopathic infant in association with the development of a hypsarrhythmic EEG pattern."2.66Three different scenarios for epileptic spasms. ( Fusco, L; Santarone, ME; Serino, D, 2020)
"The medicinal treatment of spasticity includes use of oral treatments (baclofène and tizanidine), botulinum toxin, intrathecal baclofène and local application of alcohol or phenol."2.48[Pharmacological treatment of spasticity in multiple sclerosis]. ( Heinzlef, O; Monteil-Roch, I, 2012)
"Epileptic spasms were asymmetric in three patients and unilateral in two."1.72Status of epileptic spasms: A study of 21 children. ( Buompadre, C; Caraballo, R; Chacón, S; Fasulo, L; Gallo, A; Reyes, G; Semprino, M, 2022)
"It has been known that West syndrome (WS) patients with an unknown etiology have better clinical outcomes than patients with an identified etiology of any kind."1.62Disparate treatment outcomes according to presence of pathogenic mutations in West syndrome. ( Choi, HS; Choi, JR; Kang, HC; Kim, HD; Kim, SH; Ko, A; Lee, JS; Lee, ST, 2021)
"In five cases, tonic seizures preceded spasms at a median age of 6 weeks."1.51New insights in phenomenology and treatment of epilepsy in CDKL5 encephalopathy. ( Bienvenu, T; Chikvinidze, G; Dulac, O; Epitashvili, N; Gataullina, S; Melikishvili, G; Tabatadze, N, 2019)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (17.39)29.6817
2010's4 (17.39)24.3611
2020's15 (65.22)2.80

Authors

AuthorsStudies
Caraballo, R1
Semprino, M1
Fasulo, L1
Reyes, G1
Chacón, S1
Gallo, A1
Buompadre, C1
Harvey, S1
Allen, NM1
King, MD1
Lynch, B1
Lynch, SA1
O'Regan, M1
O'Rourke, D1
Shahwan, A1
Webb, D1
Gorman, KM1
Barrett, KT1
Choudhary, A1
Charkhand, B1
Scantlebury, MH1
Dzau, W1
Cheng, S1
Snell, P1
Fahey, M1
Scheffer, IE1
Harvey, AS1
Howell, KB1
Sánchez Fernández, I1
Amengual-Gual, M1
Barcia Aguilar, C1
Romeu, A1
Sheikh, T1
Torres, A1
Chao, J1
Jonas, R1
Gaínza-Lein, M1
Harini, C2
Douglass, L1
Osborne, JP1
Edwards, SW1
Alber, FD1
Hancock, E1
Johnson, AL1
Kennedy, CR1
Likeman, M1
Lux, AL1
Mackay, M1
Mallick, A1
Newton, RW1
Nolan, M1
Pressler, R1
Rating, D1
Schmitt, B1
Verity, CM1
O'Callaghan, FK1
Riikonen, R1
Xu, Z1
Gong, P1
Jiao, X1
Niu, Y1
Wu, Y1
Zhang, Y1
Chang, X1
Yang, Z1
Olson, HE1
Demarest, S1
Pestana-Knight, E1
Moosa, AN1
Zhang, X1
Pérez-Pérez, JR1
Weisenberg, J1
O'Connor Prange, E1
Marsh, ED1
Rajaraman, RR1
Suter, B1
Katyayan, A2
Haviland, I1
Daniels, C1
Zhang, B1
Greene, C1
DeLeo, M1
Swanson, L1
Love-Nichols, J1
Benke, T1
Poduri, A1
Takacs, DS1
Vanderslice, K1
Riviello, JJ1
Lal, P1
Sahu, JK1
Sampaio, LPB1
Henriques-Souza, AMM1
Silveira, MRMD1
Seguti, L1
Santos, MLSF1
Montenegro, MA1
Antoniuk, S1
Manreza, MLG1
Fusco, L1
Serino, D1
Santarone, ME1
Choi, HS1
Ko, A1
Kim, SH1
Lee, ST1
Choi, JR1
Lee, JS1
Kim, HD1
Kang, HC1
Desnous, B1
Lenoir, M1
Bitton, JY1
Arbour, M1
Villeneuve, N1
Whiting, S1
Mohammed, I1
Wirrell, EC1
Bello-Espinosa, L1
Ronen, GM1
Lortie, A1
Birca, A1
Zuberi, SM1
Melikishvili, G1
Epitashvili, N1
Tabatadze, N1
Chikvinidze, G1
Dulac, O1
Bienvenu, T1
Gataullina, S1
Jain, P1
Alwadhi, R1
Kumar, V1
Heinzlef, O1
Monteil-Roch, I1
Kölker, S1
Hoffmann, GF1
Schor, DS1
Feyh, P1
Wagner, L1
Jeffrey, I1
Pourfarzam, M1
Okun, JG1
Zschocke, J1
Baric, I1
Bain, MD1
Jakobs, C1
Chalmers, RA1
Auvichayapat, N1
Tassniyom, S1
Treerotphon, S1
Auvichayapat, P1
Visudhiphan, P1

Reviews

5 reviews available for vigabatrin and Spasm

ArticleYear
Animal Models in Epileptic Spasms and the Development of Novel Treatment Options.
    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 2022, Nov-01, Volume: 39, Issue:7

    Topics: Adrenocorticotropic Hormone; Animals; Anticonvulsants; Electroencephalography; Humans; Models, Anima

2022
Biochemical mechanisms in pathogenesis of infantile epileptic spasm syndrome.
    Seizure, 2023, Volume: 105

    Topics: Anticonvulsants; Epilepsy; Glucocorticoids; Humans; Infant; Spasm; Spasms, Infantile; Vigabatrin

2023
Efficacy of vigabatrin in the treatment of infantile epileptic spasms syndrome: A systematic review and meta-analysis.
    Epilepsia open, 2023, Volume: 8, Issue:2

    Topics: Anticonvulsants; Humans; Spasm; Spasms, Infantile; Syndrome; Vigabatrin

2023
Three different scenarios for epileptic spasms.
    Epilepsy & behavior : E&B, 2020, Volume: 113

    Topics: Child; Electroencephalography; Epilepsy; Humans; Infant; Spasm; Spasms, Infantile; Vigabatrin

2020
[Pharmacological treatment of spasticity in multiple sclerosis].
    Revue neurologique, 2012, Volume: 168 Suppl 3

    Topics: Algorithms; Amines; Baclofen; Botulinum Toxins, Type A; Clonidine; Cyclohexanecarboxylic Acids; Dant

2012

Other Studies

18 other studies available for vigabatrin and Spasm

ArticleYear
Status of epileptic spasms: A study of 21 children.
    Epilepsy & behavior : E&B, 2022, Volume: 126

    Topics: Anticonvulsants; Child; Electroencephalography; Epilepsy; Humans; Infant; Spasm; Spasms, Infantile;

2022
Response to treatment and outcomes of infantile spasms in Down syndrome.
    Developmental medicine and child neurology, 2022, Volume: 64, Issue:6

    Topics: Adult; Anticonvulsants; Child; Down Syndrome; Humans; Infant; Prednisolone; Seizures; Spasm; Spasms,

2022
Response to sequential treatment with prednisolone and vigabatrin in infantile spasms.
    Journal of paediatrics and child health, 2022, Volume: 58, Issue:12

    Topics: Anticonvulsants; Humans; Infant; Prednisolone; Recurrence; Retrospective Studies; Spasm; Spasms, Inf

2022
Temporal trends in the cost and use of first-line treatments for infantile epileptic spasms syndrome.
    Epilepsia, 2023, Volume: 64, Issue:3

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Child; Female; Humans; Infant; Infant, Newborn; Male;

2023
Prednisolone or tetracosactide depot for infantile epileptic spasms syndrome? A prospective analysis of data embedded within two randomised controlled trials.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2023, Volume: 42

    Topics: Anticonvulsants; Cosyntropin; Epilepsy; Humans; Infant; Prednisolone; Randomized Controlled Trials a

2023
Epileptic spasms in CDKL5 deficiency disorder: Delayed treatment and poor response to first-line therapies.
    Epilepsia, 2023, Volume: 64, Issue:7

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Female; Humans; Infant; Male;

2023
Inaccuracies in Parental Reporting of Treated Epileptic Spasms: Both Under- and Over-Reporting.
    Pediatric neurology, 2023, Volume: 145

    Topics: Electroencephalography; Humans; Infant; Spasm; Spasms, Infantile; Vigabatrin

2023
What Should be the Next Choice After Failure of Hormonal and Vigabatrin Therapy in Infantile Epileptic Spasms Syndrome?
    Indian journal of pediatrics, 2023, Volume: 90, Issue:10

    Topics: Anticonvulsants; Humans; Infant; Spasm; Spasms, Infantile; Syndrome; Treatment Outcome; Vigabatrin

2023
Brazilian experts' consensus on the treatment of infantile epileptic spasm syndrome in infants.
    Arquivos de neuro-psiquiatria, 2023, Volume: 81, Issue:9

    Topics: Anticonvulsants; Brazil; Child; Consensus; Epilepsy; Humans; Infant; Prednisolone; Recurrence; Spasm

2023
Disparate treatment outcomes according to presence of pathogenic mutations in West syndrome.
    Epilepsia, 2021, Volume: 62, Issue:7

    Topics: Age of Onset; Anti-Inflammatory Agents; Anticonvulsants; Arrhythmias, Cardiac; Child; Child, Prescho

2021
What is the optimal duration for vigabatrin monotherapy in patients with infantile spasms: 6 months or longer?
    Seizure, 2021, Volume: 91

    Topics: Anticonvulsants; Child; Humans; Infant; Prospective Studies; Retrospective Studies; Spasm; Spasms, I

2021
Precious time to respond to infantile spasms.
    The Lancet. Child & adolescent health, 2018, Volume: 2, Issue:10

    Topics: Adrenocorticotropic Hormone; Humans; Spasm; Spasms, Infantile; Vigabatrin

2018
New insights in phenomenology and treatment of epilepsy in CDKL5 encephalopathy.
    Epilepsy & behavior : E&B, 2019, Volume: 94

    Topics: Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Electroencephalography; Electro

2019
Reversible MRI Changes in an Infant with Epileptic Spasms on Low Dose Vigabatrin.
    Indian journal of pediatrics, 2016, Volume: 83, Issue:9

    Topics: Anticonvulsants; Electroencephalography; Enzyme Inhibitors; Humans; Infant; Magnetic Resonance Imagi

2016
Glutaryl-CoA dehydrogenase deficiency: region-specific analysis of organic acids and acylcarnitines in post mortem brain predicts vulnerability of the putamen.
    Neuropediatrics, 2003, Volume: 34, Issue:5

    Topics: Acidosis; Acute Disease; Adolescent; Anticonvulsants; Atrophy; Brain; Carnitine; DNA Mutational Anal

2003
Treatment of infantile spasms with sodium valproate followed by benzodiazepines.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2007, Volume: 90, Issue:9

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Clonazepam; Drug Therapy, Combination

2007
Treatment of infantile spasms with sodium valproate followed by benzodiazepines.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2007, Volume: 90, Issue:10

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Clonazepam; Drug Therapy, Combination

2007
Visual field constriction on vigabatrin.
    Prescrire international, 2000, Volume: 9, Issue:45

    Topics: Adult; Anticonvulsants; Epilepsy; Europe; Humans; Infant; Spasm; Treatment Outcome; Tuberous Scleros

2000