verapamil and Hypoxia studies

Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.

Research Excerpts

Excerpt	Relevance	Reference
"Noncardiogenic pulmonary edema has not been (to our knowledge) previously reported associated with a verapamil overdose."	7.69	Noncardiogenic pulmonary edema complicating massive verapamil overdose. ( Frumin, H; Leesar, MA; Martyn, R; Talley, JD, 1994)
" Pretreatment of animals with verapamil did not affect the abnormality of glucose metabolism but abolished the associated acidosis."	7.68	Verapamil prevents cerebral acidosis during moderate hypoxia and hypotension. ( Lockwood, AH; Yap, EW, 1991)
"Hypoxia-induced stimulation of the rate of von Willebrand factor (vWF) release from human umbilical vein endothelial cells in culture, and the influence of the calcium antagonist verapamil, was studied using a system in which a pO2 of 20 mm Hg was achieved over 60 min."	7.68	Hypoxia-induced von Willebrand factor release is blocked by verapamil. ( Blake, D; Cunningham, J; Stevens, CR; Wilkie, ME, 1992)
" We have used an isolated buffer-perfused preparation of the rabbit ear to investigate the effects of hypoxia and inhibition of endothelium-derived relaxing factor (EDRF) synthesis on the vasodilator responses to the potassium channel opener, levcromakalim (the active (-)-enantiomer of cromakalim)."	7.68	Modulation of vasodilatation to levcromakalim by hypoxia and EDRF in the rabbit isolated ear: a comparison with pinacidil, sodium nitroprusside and verapamil. ( Griffith, TM; Randall, MD, 1993)
" This report compares the activity of flunarizine and verapamil, another calcium entry blocking drug, on the central nervous system (CNS) and peripheral consequences of cytotoxic hypoxia induced by high and low doses of KCN."	7.67	Flunarizine and verapamil: effects on central nervous system and peripheral consequences of cytotoxic hypoxia in rats. ( Dubinsky, B; Ritchie, DM; Sierchio, JN; Temple, DE, 1984)
"To test whether verapamil protects myocardial high-energy phosphate content during hypoxia by reducing pre-hypoxic cardiac work or secondary to metabolic events that occur during hypoxia, we compared the relation between myocardial performance and high-energy phosphate content during normoxia, hypoxia and reoxygenation using 31P NMR spectroscopy in isolated, isovolumic buffer-perfused rat hearts."	7.67	Verapamil attenuates ATP depletion during hypoxia: 31P NMR studies of the isolated rat heart. ( Ingwall, JS; Neubauer, S, 1989)
"Myocardial hypoxia, induced by arrest of the artificial ventilation of anaesthetized open-chest rats, was utilized in order to study some aspects of the regulation of myocardial glycogen metabolism."	7.67	[Enzyme activity of cardiac glycogen metabolism: study of an in situ hypoxia protocol in the rat]. ( Grably, S; Rossi, A; Verdys, M, 1989)
"Changes in cAMP content of tissues of lung, heart and aorta and in blood plasma of rats during chronic hypoxia and administration of verapamil were determined and investigated."	7.67	Effects of chronic hypoxia and verapamil on cAMP content in tissues and blood plasma. ( Cai, YN; Yuan, XJ, 1989)
" We have investigated the effect of the calcium antagonist verapamil upon the polycythaemic response to hypoxia in rats."	7.67	Effect of verapamil on polycythaemia secondary to hypoxia in rats. ( Cameron, IR; Douglas, AR; Moore-Gillon, JC; Sheldon, JW, 1987)
" The bi-fluorophenyl-piperazine derivatives, lidoflazine and flunarizine, enhanced the reactive hyperemia elicited by a brief (30 s) anoxic challenge."	7.67	The effects of lidoflazine and flunarizine on cerebral reactive hyperemia. ( DeLong, RE; Phillis, JW; Towner, JK, 1985)
"Adult male Wistar rats were used for studying the effect of Ca2+ antagonist verapamil on pulmonary hypertension, right ventricular hypertrophy and the medial thickness of pulmonary arterioles, induced by intermittent high altitude (IHA) hypoxia."	7.66	Effect of verapamil on pulmonary hypertension and right ventricular hypertrophy induced in rats by intermittent high altitude hypoxia. ( Ostádal, B; Pelouch, V; Procházka, J; Ressl, J; Urbanová, D; Widimský, J, 1981)
"In calves with hypoxic pulmonary hypertension, resistance was reduced by 40 +/- 3% with normoxia, 19 +/- 4% with verapamil, and 60 +/- 1% with hexoprenaline."	7.65	Reduction of bovine pulmonary hypertension by normoxia, verapamil and hexoprenaline. ( Grover, RF; McMurtry, IF; Reeves, JT; Will, DH, 1977)
" At their maximal safe dosage in humans, methysergide and verapamil suggest no role for serotonin and calcium ions."	6.66	Ventilatory response to sustained hypoxia: effect of methysergide and verapamil. ( Anthonisen, NR; Balakumar, M; Easton, PA; Filuk, R; Long, GR, 1989)
"1."	5.29	Trandolapril plus verapamil inhibits the coronary vasospasm induced by hypoxia following ischemia-reperfusion injury in dogs. ( Boulanger, CM; Kirchengast, M; Lee, JJ; Vanhoutte, PM, 1996)
"Verapamil (0."	5.28	Effects of manganese chloride, verapamil, and hypoxia on the rate-dependent increase in internal longitudinal resistance of rabbit myocardium. ( Alvarez, J; Dorticós, F; Morlans, J; Rousseau, G, 1989)
"Pretreatment with verapamil inhibited thromboxane synthesis, the rise in pulmonary artery pressure and the hypoxia without affecting the transient leukopenia."	5.27	Effects of verapamil on thromboxane synthesis and pulmonary hypertension in sheep. ( Davies, BJ; McDonald, JW; Noulty, EJ; Pisters, LL; Smallbone, BW; Taylor, NE, 1986)
"Acute hypoxia did not alter the pharmacokinetics of theophylline [half-life+/-SD: 9."	5.11	Cytochrome P450 enzyme-mediated drug metabolism at exposure to acute hypoxia (corresponding to an altitude of 4,500 m). ( Bärtsch, P; Burhenne, J; Dehnert, C; Göggelmann, C; Haefeli, WE; Menold, E; Mikus, G; Riedel, KD; Streit, M, 2005)
" Biochemical evidence suggests that pulmonary vasoconstriction results from the transmembrane flux of calcium into vascular smooth muscle; accordingly, the pulmonary pressor responses in experimental hypoxic pulmonary hypertension can be attenuated by verapamil and nifedipine."	4.77	Therapeutic application of calcium-channel antagonists for pulmonary hypertension. ( Packer, M, 1985)
"Pregnancy increased diazoxide, but not verapamil-induced relaxations."	3.76	Role of KATP and L-type Ca2+ channel activities in regulation of ovine uterine vascular contractility: effect of pregnancy and chronic hypoxia. ( Longo, LD; Xiao, D; Zhang, L, 2010)
"Noncardiogenic pulmonary edema has not been (to our knowledge) previously reported associated with a verapamil overdose."	3.69	Noncardiogenic pulmonary edema complicating massive verapamil overdose. ( Frumin, H; Leesar, MA; Martyn, R; Talley, JD, 1994)
"Hypoxia-induced stimulation of the rate of von Willebrand factor (vWF) release from human umbilical vein endothelial cells in culture, and the influence of the calcium antagonist verapamil, was studied using a system in which a pO2 of 20 mm Hg was achieved over 60 min."	3.68	Hypoxia-induced von Willebrand factor release is blocked by verapamil. ( Blake, D; Cunningham, J; Stevens, CR; Wilkie, ME, 1992)
" We have used an isolated buffer-perfused preparation of the rabbit ear to investigate the effects of hypoxia and inhibition of endothelium-derived relaxing factor (EDRF) synthesis on the vasodilator responses to the potassium channel opener, levcromakalim (the active (-)-enantiomer of cromakalim)."	3.68	Modulation of vasodilatation to levcromakalim by hypoxia and EDRF in the rabbit isolated ear: a comparison with pinacidil, sodium nitroprusside and verapamil. ( Griffith, TM; Randall, MD, 1993)
" Pretreatment of animals with verapamil did not affect the abnormality of glucose metabolism but abolished the associated acidosis."	3.68	Verapamil prevents cerebral acidosis during moderate hypoxia and hypotension. ( Lockwood, AH; Yap, EW, 1991)
"In anesthetized and thoracotomized 20 adult dogs under artificial respiration, the effects of calcium blockers (nifedipine, diltiazem and verapamil) on the mechanics of the left and right cardiac pumps under acute hypoxia were observed."	3.68	[Effects of calcium blockers on the performance of left and right ventricles during acute hypoxia]. ( Gu, LM; Xiao, Y; Yuan, F; Zhou, ZN, 1992)
"Effects of "Qi-Xue" injection (Panax ginseng, Astragalus monogholicus, Angelica sinensis), verapamil (Vp, calcium antagonist) and their combination on pulmonary arterial pressure (PAP) and heart function were studied in rats exposed to chronic hypoxia."	3.68	[Prevention of hypoxic pulmonary hypertension with "qi-xue" injection]. ( Zhao, L, 1990)
"Cardiovascular responses to the calcium antagonists verapamil and nifedipine were evaluated in a piglet model of hypoxic pulmonary hypertension."	3.67	The effect of calcium antagonists on hypoxic pulmonary hypertension in the piglet. ( Bancalari, E; Dickstein, PJ; Goldberg, RN; Trindade, O, 1984)
" This report compares the activity of flunarizine and verapamil, another calcium entry blocking drug, on the central nervous system (CNS) and peripheral consequences of cytotoxic hypoxia induced by high and low doses of KCN."	3.67	Flunarizine and verapamil: effects on central nervous system and peripheral consequences of cytotoxic hypoxia in rats. ( Dubinsky, B; Ritchie, DM; Sierchio, JN; Temple, DE, 1984)
"To test whether verapamil protects myocardial high-energy phosphate content during hypoxia by reducing pre-hypoxic cardiac work or secondary to metabolic events that occur during hypoxia, we compared the relation between myocardial performance and high-energy phosphate content during normoxia, hypoxia and reoxygenation using 31P NMR spectroscopy in isolated, isovolumic buffer-perfused rat hearts."	3.67	Verapamil attenuates ATP depletion during hypoxia: 31P NMR studies of the isolated rat heart. ( Ingwall, JS; Neubauer, S, 1989)
"Changes in cAMP content of tissues of lung, heart and aorta and in blood plasma of rats during chronic hypoxia and administration of verapamil were determined and investigated."	3.67	Effects of chronic hypoxia and verapamil on cAMP content in tissues and blood plasma. ( Cai, YN; Yuan, XJ, 1989)
"88 mM Amytal (amobarbital), hypoxia (95% N2-5% CO2), or 12 microM adenosine in the presence and absence of 2."	3.67	Relationship of myocardial metabolism and coronary flow: dependence on extracellular calcium. ( Erecińska, M; Rumsey, WL; Wilson, DF, 1987)
"Myocardial hypoxia, induced by arrest of the artificial ventilation of anaesthetized open-chest rats, was utilized in order to study some aspects of the regulation of myocardial glycogen metabolism."	3.67	[Enzyme activity of cardiac glycogen metabolism: study of an in situ hypoxia protocol in the rat]. ( Grably, S; Rossi, A; Verdys, M, 1989)
"The objectives of this study were to examine the independent and combined effects of beta blockade (practolol) and calcium channel blockade (verapamil) on cardiac responses to hypoxia in the neonate."	3.67	Potentiation by calcium channel blockade of hypoxic myocardial depression in the neonate. ( Downing, SE, 1985)
" We have investigated the effect of the calcium antagonist verapamil upon the polycythaemic response to hypoxia in rats."	3.67	Effect of verapamil on polycythaemia secondary to hypoxia in rats. ( Cameron, IR; Douglas, AR; Moore-Gillon, JC; Sheldon, JW, 1987)
"In order to determine the influence of calcium on erythropoietin release in response to hypoxia, the effects of the calcium entry blocker verapamil on erythropoietin production were investigated."	3.67	Enhanced erythropoietin production by calcium entry blockers in rats exposed to hypoxia. ( Brookins, J; Fisher, JW; McGonigle, RJ; Pegram, BL, 1987)
"Effects of hypoxia on atrioventricular conduction were investigated in the Langendorff-perfused isolated heart of the rabbit with various extracellular calcium concentrations ([Ca2+]) as well as in the presence of verapamil, nifedipine, N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W-7) and chlorpromazine."	3.67	Effects of calcium, calcium entry blockers and calmodulin inhibitors on atrioventricular conduction disturbances induced by hypoxia. ( Anno, T; Kodama, I; Shibata, S; Toyama, J; Yamada, K, 1986)
"9 microM), the Ca++ channel blocker verapamil (2 microM), and CaCl2 (6 mM) on a model of heart damage, hypoxia/reoxygenation of isolated guinea-pig hearts."	3.67	TEA prevents the decline of the duration of the action potential in hypoxic cardiac muscle. ( Asano, T; Kasuya, Y; Shigenobu, K, 1985)
" The bi-fluorophenyl-piperazine derivatives, lidoflazine and flunarizine, enhanced the reactive hyperemia elicited by a brief (30 s) anoxic challenge."	3.67	The effects of lidoflazine and flunarizine on cerebral reactive hyperemia. ( DeLong, RE; Phillis, JW; Towner, JK, 1985)
"Experiments were undertaken to determine if drugs (verapamil, propranolol, and methylprednisolone sodium saccinate) that protect the fine ultrastructure of heart muscle against damage caused by hypoxia, protect mitochondrial function."	3.66	Pharmacological protection of mitochondrial function in hypoxic heart muscle: Effect of verapamil, propranolol, and methylprednisolone. ( Fassold, E; Nayler, WG; Yepez, C, 1978)
"Adult male Wistar rats were used for studying the effect of Ca2+ antagonist verapamil on pulmonary hypertension, right ventricular hypertrophy and the medial thickness of pulmonary arterioles, induced by intermittent high altitude (IHA) hypoxia."	3.66	Effect of verapamil on pulmonary hypertension and right ventricular hypertrophy induced in rats by intermittent high altitude hypoxia. ( Ostádal, B; Pelouch, V; Procházka, J; Ressl, J; Urbanová, D; Widimský, J, 1981)
" The vascular reactivity of isolated, blood-perfused rat lungs was established by eliciting pressor responses to airway hypoxia and to intraarterial angiotensin II."	3.66	Inhibitors of oxidative ATP production cause transient vasoconstriction and block subsequent pressor responses in rat lungs. ( McMurtry, IF; Rounds, S, 1981)
"The influence of an increased Ca concentration on reactive hyperemia, work induced vasodilation and pharmacologically induced dilation (adenosine, nifedipine, verapamil) was studied in the blood perfused gastrocnemius of dogs."	3.65	[The effect of increased extracellular calcium concentration on the hypoxic and pharmacologic hyperemia of skeletal muscle]. ( Marten, W; Meyer, VU; Raff, WK; Schiffer, W, 1975)
"In calves with hypoxic pulmonary hypertension, resistance was reduced by 40 +/- 3% with normoxia, 19 +/- 4% with verapamil, and 60 +/- 1% with hexoprenaline."	3.65	Reduction of bovine pulmonary hypertension by normoxia, verapamil and hexoprenaline. ( Grover, RF; McMurtry, IF; Reeves, JT; Will, DH, 1977)
" At their maximal safe dosage in humans, methysergide and verapamil suggest no role for serotonin and calcium ions."	2.66	Ventilatory response to sustained hypoxia: effect of methysergide and verapamil. ( Anthonisen, NR; Balakumar, M; Easton, PA; Filuk, R; Long, GR, 1989)
"IPA treated with thapsigargin (1 microM) in Ca2+-free solution to deplete Ca2+ stores showed sustained constriction upon re-exposure to Ca2+ and an increase in the rate of Mn2+ influx, suggesting capacitative Ca2+ entry."	1.31	Voltage-independent calcium entry in hypoxic pulmonary vasoconstriction of intrapulmonary arteries of the rat. ( Aaronson, PI; Hague, D; Robertson, TP; Ward, JP, 2000)
"1."	1.29	Trandolapril plus verapamil inhibits the coronary vasospasm induced by hypoxia following ischemia-reperfusion injury in dogs. ( Boulanger, CM; Kirchengast, M; Lee, JJ; Vanhoutte, PM, 1996)
"In a second group (n = 9), hypoxemia induced marked significant decreases in GFR, RBF and urine flow rate (-22 +/- 5%, -18 +/- 6% and -34 +/- 7% respectively)."	1.29	Protection from hypoxemic renal dysfunction by verapamil and manganese in the rabbit. ( Guignard, JP; Heumann, C; Semama, D, 1995)
"Verapamil's inhibition was rapid in onset and disappearance; changes in glucose transport rate were detectable when verapamil was added to or removed from the incubation medium 15 min prior to measurement of glucose transport."	1.28	Diverse effects of calcium channel blockers on skeletal muscle glucose transport. ( Briggs-Tung, C; Cartee, GD; Holloszy, JO, 1992)
"Verapamil (0."	1.28	Effects of manganese chloride, verapamil, and hypoxia on the rate-dependent increase in internal longitudinal resistance of rabbit myocardium. ( Alvarez, J; Dorticós, F; Morlans, J; Rousseau, G, 1989)
" AB and hypoxia/reoxygenation caused additive, not synergistic, LDH release whereas CS-AB had no adverse effect."	1.28	Direct amphotericin B-mediated tubular toxicity: assessments of selected cytoprotective agents. ( Bredl, CR; Schimpf, BA; Zager, RA, 1992)
" No clinically useful benefit was found with verapamil in the dosage used in this group of patients and the value of calcium antagonists in the treatment of patients with chronic obstructive lung disease requires further clarification."	1.27	Effects of verapamil on pulmonary haemodynamics during hypoxaemia, at rest, and during exercise in patients with chronic obstructive pulmonary disease. ( Blair, GP; Brown, SE; King, RR; Light, RW; Linden, GS; Stansbury, DW, 1983)
"Anoxia has been shown to potentiate the constrictor effects of 5-hydroxytryptamine (5HT) in isolated vascular tissue."	1.27	Effects of nitroglycerin, dipyridamole, nifedipine, verapamil and diltiazem on canine coronary arterial rings contracted with 5-hydroxytryptamine and anoxia. ( Balkon, J; Barrett, JA; DePaul Lynch, V; Smith, RD; Wolf, PS, 1986)
"Pretreatment with verapamil inhibited thromboxane synthesis, the rise in pulmonary artery pressure and the hypoxia without affecting the transient leukopenia."	1.27	Effects of verapamil on thromboxane synthesis and pulmonary hypertension in sheep. ( Davies, BJ; McDonald, JW; Noulty, EJ; Pisters, LL; Smallbone, BW; Taylor, NE, 1986)
"When monensin was applied simultaneously with ouabain, there was a rapid increase in cellular Na+ and loss of cellular K+."	1.27	Action of the Na+ ionophore monensin on vascular smooth muscle of guinea-pig aorta. ( Chihara, S; Kishimoto, T; Ozaki, H; Umeno, H; Urakawa, N, 1984)
"Verapamil was more active than nifedipine in both models."	1.27	Evaluation of cardiac anoxia and ischemia models in the rat using calcium antagonists. ( Jacobs, LW; Rosenberger, LB; Stanton, HC, 1984)
"After 45 min of anoxia and a 4- to 6-hr incubation in normal Ca++-containing media, cells from all segments were dead."	1.27	Beneficial effects of calcium channel blockers and calmodulin binding drugs on in vitro renal cell anoxia. ( Schrier, RW; Schwertschlag, U; Wilson, P, 1986)
"Propranolol was either added at the start of the hypoxic perfusion or the rabbit were pretreated with it."	1.26	[Creatine phosphokinase release from perfused cardiac muscle under hypoxic conditions. Effect of propranolol, verapamil, reserpine and deslanoside]. ( Bongrani, S; Ferrari, R, 1979)
"In the isolated rat heart, anoxia or ischemia do not induce important ventricular tachyarrhythmias (VTAs)."	1.26	Inhibitory effect of anoxia on reperfusion- and digitalis-induced ventricular tachyarrhythmias. ( Carbonin, P; Di Gennaro, M; Valle, R; Weisz, AM, 1981)

Timeframe	Studies, this research(%)	All Research%
pre-1990	84 (70.00)	18.7374
1990's	27 (22.50)	18.2507
2000's	6 (5.00)	29.6817
2010's	3 (2.50)	24.3611
2020's	0 (0.00)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
Effects of High Altitude on 5' Adenosine Monophosphate-activated Protein Kinase (AMPK) Activation and Peroxisome Proliferator-activated Receptor Gamma (PPARγ) Regulation[NCT02391519]				84 participants (Anticipated)	Observational	2016-01-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
[Hypoxic pulmonary hypertension: modern views on pathogenesis and options for rational pharmacological correction]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2012, Volume: 58, Issue:2 Topics: Antihypertensive Agents; Calcium Channel Blockers; Calcium Channels; Humans; Hypertension, Pulmonary	2012
[Recent advances and future perspectives in the medical treatment of cardiopathies in children]. Revista espanola de cardiologia, 1984, Volume: 37 Suppl 1 Topics: Child; Ductus Arteriosus, Patent; Heart Defects, Congenital; Heart Failure; Humans; Hypoxia; Indomet	1984
Therapeutic application of calcium-channel antagonists for pulmonary hypertension. The American journal of cardiology, 1985, Jan-25, Volume: 55, Issue:3 Topics: Animals; Calcium Channel Blockers; Cattle; Diltiazem; Hemodynamics; Humans; Hypertension, Pulmonary;	1985
[Is adenosine the mediator for the regulation of the coronary circulation and for the effect of coronarodilators? Review]. Die Pharmazie, 1974, Volume: 29, Issue:9 Topics: Adenosine; Adenosine Triphosphate; Aminohydrolases; Aminophylline; Animals; Calcium; Carbon Dioxide;	1974
[Modern treatment of cardiac arrhythmias]. Munchener medizinische Wochenschrift (1950), 1971, Apr-16, Volume: 113, Issue:16 Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Bradycardia; Cell Membrane Permeability; Digitali	1971

Article	Year
Cytochrome P450 enzyme-mediated drug metabolism at exposure to acute hypoxia (corresponding to an altitude of 4,500 m). European journal of clinical pharmacology, 2005, Volume: 61, Issue:1 Topics: Adult; Altitude; Area Under Curve; Calcium Channel Blockers; Cross-Over Studies; Cytochrome P-450 CY	2005
Effect of verapamil on ventilatory and circulatory responses to hypoxia and hypercapnia in normal subjects. The Japanese journal of physiology, 1992, Volume: 42, Issue:5 Topics: Administration, Oral; Adult; Blood Pressure; Calcium; Carotid Body; Double-Blind Method; Electrocard	1992
Ventilatory response to sustained hypoxia: effect of methysergide and verapamil. Respiration physiology, 1989, Volume: 75, Issue:2 Topics: Adult; Calcium Channel Blockers; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hypo	1989

Article	Year
Hypoxia-Protective Azaphilone Adducts from Peyronellaea glomerata. Journal of natural products, 2018, 05-25, Volume: 81, Issue:5 Topics: Apoptosis; Ascomycota; Benzopyrans; Cells, Cultured; Crystallography, X-Ray; Endophytes; Human Umbil	2018
Role of TRP channels and NCX in mediating hypoxia-induced [Ca(2+)](i) elevation in PC12 cells. Respiratory physiology & neurobiology, 2008, Dec-31, Volume: 164, Issue:3 Topics: Animals; Boron Compounds; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Gene	2008
Efficacy of oxygen inhalation in sumatriptan refractory "high altitude" cluster headache attacks. The journal of headache and pain, 2009, Volume: 10, Issue:6 Topics: Adult; Altitude Sickness; Atmospheric Pressure; Calcium Channel Blockers; Cluster Headache; Drug Res	2009
Role of KATP and L-type Ca2+ channel activities in regulation of ovine uterine vascular contractility: effect of pregnancy and chronic hypoxia. American journal of obstetrics and gynecology, 2010, Volume: 203, Issue:6 Topics: Adenosine Triphosphate; Altitude; Animals; Arteries; Calcium Channels, L-Type; Disease Models, Anima	2010
Hypoxic rise in cytosolic calcium and renal proximal tubule injury mediated by a nickel-sensitive pathway. Experimental biology and medicine (Maywood, N.J.), 2004, Volume: 229, Issue:11 Topics: Animals; Calcium; Calcium Channel Blockers; Cytoplasm; Female; GABA Modulators; Humans; Hypoxia; Kid	2004
Hypoxia-induced cardiac hypertrophy in rabbits treated with verapamil and nifedipine. British journal of pharmacology, 1983, Volume: 80, Issue:2 Topics: Animals; Cardiomegaly; Eating; Hypoxia; Nifedipine; Organ Size; Rabbits; Verapamil	1983
On the role of cyclic nucleotides in the regulation of cardiac contractility and glycolysis during hypoxia. Acta pharmacologica et toxicologica, 1981, Volume: 48, Issue:4 Topics: Animals; Cyclic AMP; Cyclic GMP; Glycolysis; Hypoxia; Lactates; Lactic Acid; Male; Myocardial Contra	1981
[Verapamil in rats exposed to intermittent altitude hypoxia. Its effect on pulmonary hypertension, right ventricular hypertrophy and myocardial necroses (author's transl)]. Casopis lekaru ceskych, 1981, Nov-05, Volume: 120, Issue:44 Topics: Animals; Cardiomegaly; Hypertension, Pulmonary; Hypoxia; Male; Myocardium; Necrosis; Rats; Rats, Inb	1981
Effect of verapamil on pulmonary hypertension and right ventricular hypertrophy induced in rats by intermittent high altitude hypoxia. Respiration; international review of thoracic diseases, 1981, Volume: 42, Issue:4 Topics: Altitude Sickness; Animals; Body Weight; Cardiomegaly; Hematocrit; Hemodynamics; Hemoglobins; Hypert	1981
Mechanisms of hypoxia-induced decrease of load dependence of relaxation in cat papillary muscle. Pflugers Archiv : European journal of physiology, 1984, Volume: 401, Issue:4 Topics: Animals; Biomechanical Phenomena; Calcium; Cats; Hypoxia; In Vitro Techniques; Myocardial Contractio	1984
Pulmonary vascular response to digoxin in newborn lambs. Pediatric pharmacology (New York, N.Y.), 1984, Volume: 4, Issue:4 Topics: Animals; Animals, Newborn; Digoxin; Hemodynamics; Hypoxia; Oxygen Consumption; Pulmonary Circulation	1984
The effect of calcium antagonists on hypoxic pulmonary hypertension in the piglet. Pediatric research, 1984, Volume: 18, Issue:12 Topics: Animals; Animals, Newborn; Cardiac Output; Hypertension, Pulmonary; Hypoxia; Nifedipine; Pulmonary W	1984
Comparative effects of nifedipine, verapamil, and diltiazem on experimental pulmonary hypertension. The American journal of cardiology, 1983, Jan-01, Volume: 51, Issue:1 Topics: Animals; Benzazepines; Blood Pressure; Cardiac Output; Diltiazem; Dinoprost; Dogs; Dose-Response Rel	1983
Effects of verapamil on pulmonary haemodynamics during hypoxaemia, at rest, and during exercise in patients with chronic obstructive pulmonary disease. Thorax, 1983, Volume: 38, Issue:11 Topics: Aged; Blood Pressure; Hemodynamics; Humans; Hypoxia; Lung Diseases, Obstructive; Middle Aged; Physic	1983
Oxygen transport during hemodilution in normoxic and hypoxic dogs treated with verapamil. Acta anaesthesiologica Scandinavica, 1983, Volume: 27, Issue:6 Topics: Animals; Biological Transport; Dogs; Hematocrit; Hemodilution; Hemodynamics; Hypoxia; Lactates; Oxyg	1983
Mechanism of protection by verapamil and nifedipine from anoxic injury in isolated cardiac myocytes. The American journal of physiology, 1984, Volume: 246, Issue:3 Pt 1 Topics: Animals; Biomechanical Phenomena; Calcium; Hypoxia; Myocardial Contraction; Myocardium; Nifedipine;	1984
Flunarizine and verapamil: effects on central nervous system and peripheral consequences of cytotoxic hypoxia in rats. Life sciences, 1984, Mar-26, Volume: 34, Issue:13 Topics: Animals; Calcium Channel Blockers; Cinnarizine; Flunarizine; Hyperventilation; Hypoxia; Male; Pipera	1984
Evaluation of cardiac anoxia and ischemia models in the rat using calcium antagonists. Life sciences, 1984, Apr-02, Volume: 34, Issue:14 Topics: Adenine Nucleotides; Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Corona	1984
Contribution of adenosine to the regulation of cerebral blood flow: the role of calcium ions in the adenosine-induced cerebrocortical vasodilatation. Advances in experimental medicine and biology, 1984, Volume: 169 Topics: Adenosine; Animals; Calcium; Calcium Channel Blockers; Cats; Cerebral Cortex; Cerebrovascular Circul	1984
Action of the Na+ ionophore monensin on vascular smooth muscle of guinea-pig aorta. European journal of pharmacology, 1984, May-04, Volume: 100, Issue:3-4 Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Furans; Glucose; Guinea Pigs; Hypoxia; In Vitro Te	1984
Prevention and reversal of hypoxic pulmonary hypertension by calcium antagonists. The American review of respiratory disease, 1984, Volume: 130, Issue:1 Topics: Animals; Dimethyl Sulfoxide; Hydralazine; Hypertension, Pulmonary; Hypoxia; Male; Nifedipine; Pulmon	1984
The effect of extracellular calcium concentration and Ca-antagonist drugs on enzyme release and lactate production by anoxic heart cell cultures. Journal of molecular and cellular cardiology, 1980, Volume: 12, Issue:9 Topics: Animals; Calcium; Cells, Cultured; Glucose; Heart; Hypoxia; L-Lactate Dehydrogenase; Lactates; Manni	1980
Effect of the organic calcium antagonist D-600 on cerebrocortical vascular and redox responses evoked by adenosine, anoxia, and epilepsy. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1983, Volume: 3, Issue:1 Topics: Adenosine; Animals; Blood Volume; Cats; Cerebral Cortex; Cerebrovascular Circulation; Electrocardiog	1983
Regulation of cardiac contractility and glycolysis by cyclic nucleotides during hypoxia. Advances in myocardiology, 1983, Volume: 4 Topics: Animals; Calcium; Glycolysis; Hypoxia; Male; Myocardial Contraction; Myocardium; Nitroprusside; Nore	1983
The effects of inhibition of oxidative phosphorylation and glycolysis on contractility and high-energy phosphate content in cultured chick heart cells. Circulation research, 1983, Volume: 53, Issue:2 Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Chick Embryo; Cyanides; Glycolysis; Heart Ventricl	1983
Failure of verapamil to increase survival time in hypoxic mice. Proceedings of the Western Pharmacology Society, 1982, Volume: 25 Topics: Animals; Hypoxia; Male; Mice; Oxygen; Verapamil	1982
Peculiarities of AV nodal conduction and the role of slow Na current. Japanese circulation journal, 1981, Volume: 45, Issue:4 Topics: Action Potentials; Animals; Atrioventricular Node; Calcium; Heart Conduction System; Hypoxia; In Vit	1981
Inhibitory effect of anoxia on reperfusion- and digitalis-induced ventricular tachyarrhythmias. The American journal of physiology, 1981, Volume: 240, Issue:5 Topics: Animals; Coronary Disease; Guinea Pigs; Heart Ventricles; Hypoxia; Male; Medigoxin; Oxygen; Perfusio	1981
Different electrophysiological responses of canine endocardium and epicardium to combined hyperkalemia, hypoxia, and acidosis. Circulation research, 1980, Volume: 46, Issue:6 Topics: Acidosis; Action Potentials; Animals; Dogs; Electrophysiology; Endocardium; Hyperkalemia; Hypoxia; M	1980
Inhibitors of oxidative ATP production cause transient vasoconstriction and block subsequent pressor responses in rat lungs. Circulation research, 1981, Volume: 48, Issue:3 Topics: Adenosine Triphosphate; Angiotensin II; Animals; Antimycin A; Azides; Blood Pressure; Calcium; Dinit	1981
Acute hypoxia causes membrane depolarization and calcium influx in fetal pulmonary artery smooth muscle cells. The American journal of physiology, 1994, Volume: 266, Issue:4 Pt 1 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e	1994
Cellular mechanisms of hypoxia-induced contraction in human and rat pulmonary arteries. Respiration physiology, 1995, Volume: 99, Issue:2 Topics: Aged; Animals; Benzopyrans; Calcium; Calcium Channels; Cromakalim; Glyburide; Humans; Hypoxia; In Vi	1995
Protection from hypoxemic renal dysfunction by verapamil and manganese in the rabbit. Life sciences, 1995, Volume: 56, Issue:4 Topics: Animals; Calcium; Hypoxia; Kidney; Kidney Diseases; Male; Manganese; Rabbits; Verapamil	1995
Effects of catecholamines on the residual sodium channel dependent slow conduction in guinea pig ventricular muscles under normoxia and hypoxia. Cardiovascular research, 1995, Volume: 29, Issue:1 Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Calcium Channels; Catecholamines; Dose-Response Re	1995
Calcium modulation and cell injury in isolated rat proximal tubules. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1 Topics: Adenosine Triphosphate; Animals; Calcium; Cell Membrane Permeability; Cell Survival; Hypoxia; In Vit	1993
Noncardiogenic pulmonary edema complicating massive verapamil overdose. Chest, 1994, Volume: 105, Issue:2 Topics: Adult; Drug Overdose; Dyspnea; Female; Humans; Hypotension; Hypoxia; Pulmonary Edema; Verapamil	1994
Modulation of vasodilatation to levcromakalim by hypoxia and EDRF in the rabbit isolated ear: a comparison with pinacidil, sodium nitroprusside and verapamil. British journal of pharmacology, 1993, Volume: 109, Issue:2 Topics: Acetylcholine; Animals; Arginine; Benzopyrans; Cromakalim; Ear, External; Guanidines; Hypoxia; In Vi	1993
Acute hypoxia increases cytosolic calcium in cultured pulmonary arterial myocytes. The American journal of physiology, 1993, Volume: 264, Issue:3 Pt 1 Topics: Acute Disease; Animals; Caffeine; Calcium; Calcium Channels; Calcium-Transporting ATPases; Cells, Cu	1993
Trandolapril plus verapamil inhibits the coronary vasospasm induced by hypoxia following ischemia-reperfusion injury in dogs. General pharmacology, 1996, Volume: 27, Issue:6 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Calcium Channel Blockers; Coronary Vasospasm; Dog	1996
[Effect of calcium and its antagonists on hemodynamics and respiration]. Biulleten' eksperimental'noi biologii i meditsiny, 1996, Volume: 122, Issue:8 Topics: Animals; Blood Pressure; Calcium Channel Blockers; Calcium Chloride; Cardiac Output; Cats; Cerebrova	1996
The energetics of the quiescent heart muscle: high potassium cardioplegic solution and the influence of calcium and hypoxia on the rat heart. Acta physiologica Scandinavica, 1997, Volume: 160, Issue:3 Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Cardioplegic Solutions; Ener	1997
Effects of verapamil and ryanodine on activity of the embryonic chick heart during anoxia and reoxygenation. Journal of cardiovascular pharmacology, 1998, Volume: 31, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Chick Embryo; Contr	1998
Membrane potential-dependent and -independent vasodilation in small pulmonary arteries from chronically hypoxic rats. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:3 Topics: Animals; Body Weight; Cromakalim; Dinoprost; Dose-Response Relationship, Drug; Heart Ventricles; Hem	1998
Effects of hypoxia on pulmonary vascular contractility. Yonsei medical journal, 1998, Volume: 39, Issue:3 Topics: Animals; Blood Vessels; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Hypo	1998
Voltage-independent calcium entry in hypoxic pulmonary vasoconstriction of intrapulmonary arteries of the rat. The Journal of physiology, 2000, Jun-15, Volume: 525 Pt 3 Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Chelating Agents; Diltiazem;	2000
Halothane differentially decreases 5-hydroxytryptamine-induced contractions in normal and chronic hypoxic rat pulmonary arteries. Acta physiologica Scandinavica, 2001, Volume: 173, Issue:3 Topics: Anesthetics, Inhalation; Animals; Cadmium; Calcium Channel Blockers; Chronic Disease; Halothane; Hyp	2001
The effect of beta-adrenoceptor and Ca2+ antagonist drugs on the hypoxia-induced increased in resting tension. Cardiovascular research, 1978, Volume: 12, Issue:11 Topics: Adrenergic beta-Antagonists; Animals; Calcium; Depression, Chemical; Guinea Pigs; Heart Rate; Hypert	1978
The effect of Ca ion antagonist verapamil on ouabain inhibition of renal sodium reabsorption. Studies in the isolated perfused rat kidney. Current problems in clinical biochemistry, 1976, Volume: 6 Topics: Adenine Nucleotides; Adenosine Triphosphatases; Animals; Biological Transport; Calcium; Glomerular F	1976
[Creatine phosphokinase release from perfused cardiac muscle under hypoxic conditions. Effect of propranolol, verapamil, reserpine and deslanoside]. Giornale italiano di cardiologia, 1979, Volume: 9, Issue:4 Topics: Animals; Creatine Kinase; Deslanoside; Hypoxia; Lanatosides; Male; Myocardium; Propranolol; Rabbits;	1979
Pharmacological protection of mitochondrial function in hypoxic heart muscle: Effect of verapamil, propranolol, and methylprednisolone. Cardiovascular research, 1978, Volume: 12, Issue:3 Topics: Animals; Calcium; Hypoxia; In Vitro Techniques; Male; Methylprednisolone; Mitochondria, Heart; Oxida	1978
Pulmonary vascular effects of verapamil. American heart journal, 1978, Volume: 95, Issue:6 Topics: Altitude; Animals; Blood Pressure; Hypertension, Pulmonary; Hypoxia; Male; Pulmonary Circulation; Ra	1978
Reduction of bovine pulmonary hypertension by normoxia, verapamil and hexoprenaline. Experientia, 1977, Sep-15, Volume: 33, Issue:9 Topics: Airway Resistance; Animals; Blood Pressure; Calcium; Cattle; Hexoprenaline; Hypertension, Pulmonary;	1977
Angiotensin, hypoxia, verapamil and pulmonary vessels [proceedings]. The Journal of physiology, 1977, Volume: 270, Issue:1 Topics: Angiotensin II; Animals; Cats; Dogs; Ferrets; Hypoxia; In Vitro Techniques; Pulmonary Circulation; R	1977
A protective effect of verapamil on hypoxic heart muscle. Cardiovascular research, 1976, Volume: 10, Issue:6 Topics: Adenosine Triphosphate; Animals; Calcium; Creatine Kinase; Heart; Hypoxia; Male; Mitochondrial Swell	1976
[The effect of increased extracellular calcium concentration on the hypoxic and pharmacologic hyperemia of skeletal muscle]. Arzneimittel-Forschung, 1975, Volume: 25, Issue:5 Topics: Adenosine; Animals; Calcium; Dogs; Hyperemia; Hypoxia; Muscles; Nifedipine; Regional Blood Flow; Sti	1975
Inhibition of hypoxic pulmonary vasoconstriction by calcium antagonists in isolated rat lungs. Circulation research, 1976, Volume: 38, Issue:2 Topics: Angiotensin II; Animals; Calcium; Hypoxia; Male; Meclofenamic Acid; Proadifen; Prostaglandins; Prost	1976
Attenuation of hypoxic pulmonary vasoconstriction by verapamil in intact dogs. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1976, Volume: 151, Issue:3 Topics: Animals; Calcium; Dogs; Hypoxia; Lung; Muscle, Smooth; Prostaglandins F; Time Factors; Vascular Resi	1976
Effects of anoxia and glucose depletion on isolated veins of the dog. The American journal of physiology, 1976, Volume: 230, Issue:5 Topics: Acetylcholine; Animals; Dogs; Glucose; Hypoxia; In Vitro Techniques; Mesenteric Veins; Muscle Contra	1976
[Effects of calcium blockers on the performance of left and right ventricles during acute hypoxia]. Sheng li xue bao : [Acta physiologica Sinica], 1992, Volume: 44, Issue:3 Topics: Animals; Blood Pressure; Calcium Channel Blockers; Diltiazem; Dogs; Hemodynamics; Hypoxia; Male; Nif	1992
Hypoxia-induced von Willebrand factor release is blocked by verapamil. Mineral and electrolyte metabolism, 1992, Volume: 18, Issue:2-5 Topics: Calcimycin; Cells, Cultured; Endothelium, Vascular; Humans; Hypoxia; Verapamil; von Willebrand Facto	1992
Modification by hypoxia, hyperkalaemia and acidosis of the cardiac electrophysiological effects of a range of antiarrhythmic drugs. British journal of pharmacology, 1992, Volume: 107, Issue:3 Topics: Acidosis; Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Electrocardiography; Ele	1992
Direct amphotericin B-mediated tubular toxicity: assessments of selected cytoprotective agents. Kidney international, 1992, Volume: 41, Issue:6 Topics: Adenosine Triphosphate; Amphotericin B; Animals; Calcium; Cholesterol Esters; Deoxycholic Acid; Dose	1992
[The effects of calcium antagonists on ventilation-perfusion mismatching in the canine lung]. Kokyu to junkan. Respiration & circulation, 1992, Volume: 40, Issue:1 Topics: Animals; Calcium Channel Blockers; Diltiazem; Dogs; Hypoxia; Models, Biological; Nifedipine; Oxygen;	1992
Diverse effects of calcium channel blockers on skeletal muscle glucose transport. The American journal of physiology, 1992, Volume: 263, Issue:1 Pt 2 Topics: 3-O-Methylglucose; Animals; Biological Transport; Calcium Channel Blockers; Diltiazem; Dose-Response	1992
Pharmacological evidence for the role of mediators in hypoxia-induced vasoconstriction in sheep isolated intrapulmonary artery rings. European journal of pharmacology, 1991, Oct-02, Volume: 203, Issue:1 Topics: Adrenergic alpha-Antagonists; Animals; Calcium Channels; Enzyme Inhibitors; Flurbiprofen; Hypoxia; I	1991
[Verapamil and nifedipine limit hemodynamic changes in pulmonary circulation in rats with hypoxia]. Kardiologia polska, 1991, Volume: 35, Issue:12 Topics: Animals; Antihypertensive Agents; Blood Pressure; Depression, Chemical; Disease Models, Animal; Hype	1991
Verapamil prevents cerebral acidosis during moderate hypoxia and hypotension. Metabolic brain disease, 1991, Volume: 6, Issue:1 Topics: Acidosis; Animals; Brain; Glucose; Hypotension; Hypoxia; Male; Rats; Rats, Inbred Strains; Verapamil	1991
Effects of hypoxia and reoxygenation on the conversion of xanthine dehydrogenase to oxidase in Chinese hamster V79 cells. Free radical biology & medicine, 1991, Volume: 11, Issue:2 Topics: Allopurinol; Animals; Calcium; Cell Line; Cell Membrane; Cricetinae; Cricetulus; Glucose; Hypoxia; L	1991
Contrasting effects of hypoxia on tension in rat pulmonary and mesenteric arteries. The American journal of physiology, 1990, Volume: 259, Issue:2 Pt 2 Topics: Animals; Benzopyrans; Cromakalim; Endothelium, Vascular; Glyburide; Hypoxia; In Vitro Techniques; Ma	1990
[Prevention of hypoxic pulmonary hypertension with "qi-xue" injection]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1990, Volume: 12, Issue:1 Topics: Animals; Drugs, Chinese Herbal; Hypertension, Pulmonary; Hypoxia; Injections; Male; Panax; Plants, M	1990
Triggered activity induced by combined mild hypoxia and acidosis in guinea-pig Purkinje fibers. Journal of molecular and cellular cardiology, 1986, Volume: 18, Issue:12 Topics: Acidosis; Animals; Arrhythmias, Cardiac; Calcium; Female; Guinea Pigs; Heart Conduction System; Hypo	1986
Relationship of myocardial metabolism and coronary flow: dependence on extracellular calcium. The American journal of physiology, 1987, Volume: 253, Issue:5 Pt 2 Topics: Adenosine Triphosphate; Amobarbital; Animals; Calcium; Calcium Channel Blockers; Coronary Circulatio	1987
[Enzyme activity of cardiac glycogen metabolism: study of an in situ hypoxia protocol in the rat]. Archives internationales de physiologie et de biochimie, 1989, Volume: 97, Issue:2 Topics: Animals; Atenolol; Calcium; Cyclic AMP; Enzyme Activation; Female; Glycogen; Glycogen Synthase; Hear	1989
Effects of chronic hypoxia and verapamil on cAMP content in tissues and blood plasma. Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao, 1989, Volume: 4, Issue:1 Topics: Animals; Carotid Arteries; Cyclic AMP; Heart; Hypoxia; Lung; Male; Muscle, Smooth, Vascular; Myocard	1989
Verapamil attenuates ATP depletion during hypoxia: 31P NMR studies of the isolated rat heart. Journal of molecular and cellular cardiology, 1989, Volume: 21, Issue:11 Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Energy Metabolism; Heart; Hemodynamics; Hydro	1989
Effects of dextrose, verapamil and magnesium during hypoxia in myocardial tissue. Clinical physiology and biochemistry, 1989, Volume: 7, Issue:6 Topics: Action Potentials; Anaerobiosis; Animals; Calcium; Dogs; Female; Glucose; Heart; Hypoxia; Magnesium;	1989
Serotonin uptake and configurational change of bovine pulmonary artery smooth muscle cells in culture. Journal of cellular physiology, 1989, Volume: 138, Issue:1 Topics: Animals; Cattle; Cell Division; Cells, Cultured; Hypoxia; Imipramine; Microscopy, Phase-Contrast; Mu	1989
Interaction of verapamil and halogenated inhalation anesthetics on hypoxic pulmonary vasoconstriction. Acta anaesthesiologica Scandinavica, 1989, Volume: 33, Issue:3 Topics: Anesthesia, Inhalation; Animals; Blood Pressure; Calcium Chloride; Drug Interactions; Halothane; Hyp	1989
Effects of hypoxia on the pharmacological responsiveness of isolated coronary artery rings from the sheep. British journal of pharmacology, 1989, Volume: 96, Issue:4 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Coronary Vessels; Hypox	1989
Effects of manganese chloride, verapamil, and hypoxia on the rate-dependent increase in internal longitudinal resistance of rabbit myocardium. Canadian journal of physiology and pharmacology, 1989, Volume: 67, Issue:4 Topics: Animals; Chlorides; Electric Conductivity; Electric Stimulation; Hypoxia; In Vitro Techniques; Manga	1989
Effect of emopamil on cerebrocortical microcirculation during hypoxia and reactive hyperemia and on [K+]e, pH, pO2 changes during and after N2 anoxia. Advances in experimental medicine and biology, 1989, Volume: 248 Topics: Animals; Calcium Channel Blockers; Cats; Cerebral Cortex; Hydrogen-Ion Concentration; Hyperemia; Hyp	1989
[Influence of antianginal drugs on Lypressin induced T-wave enhancement in the electrocardiogram of the rat]. Arzneimittel-Forschung, 1986, Volume: 36, Issue:10 Topics: Administration, Oral; Angina Pectoris; Animals; Coronary Vasospasm; Electrocardiography; Hypoxia; Is	1986
Verapamil depresses the synthesis of lipoxygenase products by hypoxic cardiac rat fibroblasts in culture. Biochemical pharmacology, 1986, Jun-01, Volume: 35, Issue:11 Topics: Anaerobiosis; Animals; Cells, Cultured; Fibroblasts; Hypoxia; Kinetics; Lipoxygenase Inhibitors; Myo	1986
Effects of nitroglycerin, dipyridamole, nifedipine, verapamil and diltiazem on canine coronary arterial rings contracted with 5-hydroxytryptamine and anoxia. Pharmacology, 1986, Volume: 33, Issue:3 Topics: Animals; Arteries; Calcium; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Dipyridamole; Dog	1986
Verapamil enhances brain function tolerance against severe hypoxia without enhancing cerebral blood flow in the rat. Pharmacology, 1987, Volume: 35, Issue:2 Topics: Animals; Blood Pressure; Brain; Carbon Dioxide; Cerebrovascular Circulation; Electrocardiography; El	1987
Effect of verapamil on polycythaemia secondary to hypoxia in rats. Clinical science (London, England : 1979), 1987, Volume: 73, Issue:6 Topics: Animals; Carbon Dioxide; Erythrocyte Volume; Hematocrit; Hemoglobins; Hypoxia; Male; Oxygen; Polycyt	1987
Calcium and hypoxic injury in the renal medulla of the perfused rat kidney. Kidney international, 1988, Volume: 34, Issue:2 Topics: Amino Acids; Animals; Calcium-Binding Proteins; Glomerular Filtration Rate; Hypercalcemia; Hypoxia;	1988
Diltiazem and verapamil reduce the loss of adenine nucleotide metabolites from hypoxic hearts. Journal of molecular and cellular cardiology, 1988, Volume: 20, Issue:5 Topics: Adenine Nucleotides; Adenosine; Animals; Body Water; Calcium; Creatine Kinase; Diltiazem; Female; He	1988
[Hemodynamic effect of a single intravenous dose of verapamil in patients with hypoxemic pulmonary hypertension]. Pneumonologia polska, 1988, Volume: 56, Issue:9 Topics: Adult; Aged; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Hypoxia; Infusions, Intravenous;	1988
Slow channel inhibitor effects on brain function: tolerance to severe hypoxia in the rat. British journal of pharmacology, 1988, Volume: 95, Issue:3 Topics: Animals; Bencyclane; Bepridil; Brain; Calcium Channel Blockers; Cinnarizine; Diltiazem; Electroencep	1988
The acute haemodynamic effects of intravenous verapamil in patients with chronic obstructive airways disease. The Quarterly journal of medicine, 1987, Volume: 65, Issue:247 Topics: Acute Disease; Cardiac Output; Female; Hemodynamics; Humans; Hypoxia; Infusions, Intravenous; Lung D	1987
Calcium antagonists stimulate prostaglandin synthesis by cultured rat cardiac myocytes and prevent the effects of hypoxia. Biochemical pharmacology, 1986, Dec-15, Volume: 35, Issue:24 Topics: Animals; Bepridil; Calcium Channel Blockers; Cells, Cultured; Cobalt; Diltiazem; Dinoprostone; Epopr	1986
Enhanced erythropoietin production by calcium entry blockers in rats exposed to hypoxia. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2 Topics: Animals; Biological Assay; Blood Pressure; Calcium Channel Blockers; Erythropoietin; Female; Hypoxia	1987
Effects of indomethacin or verapamil on dialysis induced leucopenia and hypoxia in the unstressed sheep. Progress in clinical and biological research, 1987, Volume: 242 Topics: Animals; Extracorporeal Circulation; Hypoxia; Indomethacin; Leukopenia; Renal Dialysis; Sheep; Verap	1987
Effects of calcium, calcium entry blockers and calmodulin inhibitors on atrioventricular conduction disturbances induced by hypoxia. British journal of pharmacology, 1986, Volume: 88, Issue:1 Topics: Animals; Atrioventricular Node; Calcium; Calcium Channel Blockers; Calmodulin; Chlorpromazine; Heart	1986
Beneficial effects of calcium channel blockers and calmodulin binding drugs on in vitro renal cell anoxia. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:1 Topics: Animals; Calcium Channel Blockers; Calmodulin; Cell Survival; Cells, Cultured; Hypoxia; Isomerism; N	1986
External pH dependency of delayed afterdepolarization in rabbit myocardium. The American journal of physiology, 1986, Volume: 251, Issue:2 Pt 2 Topics: Animals; Doxorubicin; Electrophysiology; Female; Hydrogen-Ion Concentration; Hypoxia; In Vitro Techn	1986
Effects of verapamil on thromboxane synthesis and pulmonary hypertension in sheep. Clinical and investigative medicine. Medecine clinique et experimentale, 1986, Volume: 9, Issue:3 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Complement Activation; Female; Hypertension, Pulmonary; Hypox	1986
Verapamil improves defective duodenal calcium absorption in experimental chronic renal failure. Mineral and electrolyte metabolism, 1986, Volume: 12, Issue:5-6 Topics: Aminoquinolines; Animals; Calcium; Duodenum; Hypoxia; Intestinal Absorption; Kidney Cortex; Kidney F	1986
Maps of optical action potentials and NADH fluorescence in intact working hearts. The American journal of physiology, 1987, Volume: 252, Issue:2 Pt 2 Topics: Action Potentials; Algorithms; Animals; Coronary Vessels; Fluorescence; Guinea Pigs; Heart; Heart Ra	1987
TEA prevents the decline of the duration of the action potential in hypoxic cardiac muscle. Japanese journal of pharmacology, 1985, Volume: 38, Issue:1 Topics: Action Potentials; Animals; Calcimycin; Calcium Chloride; Guinea Pigs; Heart; Hypoxia; In Vitro Tech	1985
Effect of verapamil on ventilation and chemical control of breathing in anesthetized rats. Canadian journal of physiology and pharmacology, 1985, Volume: 63, Issue:12 Topics: Anesthesia; Animals; Carbon Dioxide; Hypoxia; Male; Rats; Respiration; Vagotomy; Verapamil	1985
Myocardial reoxygenation damage: can it be circumvented? Cardiovascular research, 1985, Volume: 19, Issue:5 Topics: Animals; Calcium; Cats; Diltiazem; Heart; Hypoxia; In Vitro Techniques; Lidoflazine; Myocardial Cont	1985
The effects of lidoflazine and flunarizine on cerebral reactive hyperemia. European journal of pharmacology, 1985, Jun-19, Volume: 112, Issue:3 Topics: Animals; Blood Gas Analysis; Cerebrovascular Circulation; Cinnarizine; Extracorporeal Circulation; F	1985
Potentiation by calcium channel blockade of hypoxic myocardial depression in the neonate. American heart journal, 1985, Volume: 110, Issue:2 Topics: Animals; Animals, Newborn; Calcium Channel Blockers; Diastole; Hypoxia; Myocardial Contraction; Prac	1985
[Differentiation between real and apparent beta receptor blockade in the heart]. Arzneimittel-Forschung, 1974, Volume: 24, Issue:3 Topics: Adenosine; Adrenergic beta-Antagonists; Animals; Electrocardiography; Glycogen; Heart; Heart Rate; H	1974
[Effects of coronary vaso dilators on myocardial survival time in the rat under anoxia conditions]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1974, Jul-01, Volume: 29, Issue:13 Topics: Animals; Coronary Circulation; Dipyridamole; Female; Heart; Hypoxia; Male; Myocardium; Nitroglycerin	1974
[Effect of Verapamil on the metabolism of myocardium]. Arzneimittel-Forschung, 1970, Volume: 20, Issue:5 Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Asphyxia; Blood Glucos	1970
[Studies on coronary-active substances]. Arzneimittel-Forschung, 1970, Volume: 20 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Circulation; Calcium; Cell Membrane Per	1970
[Studies on coronary-active substances]. Arzneimittel-Forschung, 1970, Volume: 20 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Circulation; Calcium; Cell Membrane Per	1970
[Control of myocardial metabolism by verapamil. Sites of action and therapeutic effects]. Arzneimittel-Forschung, 1970, Volume: 20 Topics: Animals; Anti-Arrhythmia Agents; Calcium; Cell Membrane Permeability; Guinea Pigs; Heart; Heart Cond	1970
[On the protective effect of iproveratil in myocardial diseases due to hypertension in animal experiment]. Die Medizinische Welt, 1967, Dec-09, Volume: 49 Topics: Animals; Anti-Arrhythmia Agents; Electrocardiography; Heart Diseases; Hypertension, Renal; Hypoxia;	1967

verapamil and Hypoxia

Research Excerpts

Research

Studies (120)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Li, TX	1
Liu, RH	1
Wang, XB	1
Luo, J	1
Luo, JG	1
Kong, LY	1
Yang, MH	1
Meng, F	1
To, WK	1
Gu, Y	1
Mampreso, E	1
Maggioni, F	1
Viaro, F	1
Disco, C	1
Zanchin, G	1
Xiao, D	1
Longo, LD	1
Zhang, L	1
Strielkov, IeV	1
Frantsuzova, SB	1
Khromov, OS	1
Barac-Nieto, M	1
Constantinescu, A	1
Pina-Benabou, MH	1
Rozental, R	1
Streit, M	1
Göggelmann, C	1
Dehnert, C	1
Burhenne, J	1
Riedel, KD	1
Menold, E	1
Mikus, G	1
Bärtsch, P	1
Haefeli, WE	1
Dukes, ID	1
Vaughan Williams, EM	1
Metsä-Ketelä, T	2
Laustiola, K	2
Lilius, EM	1
Vapaatalo, H	2
Gracián Gómez, M	1
Rodríguez Caamaño, J	1
Guía Torrent, JM	1
Ostádal, B	2
Widimský, J	2
Urbanová, D	2
Procházka, J	2
Pelouch, V	2
Ressl, J	1
Sys, SU	1
Housmans, PR	1
Van Ocken, ER	1
Brutsaert, DL	1
Milstein, JM	1
Goetzman, BW	1
Dickstein, PJ	1
Trindade, O	1
Goldberg, RN	1
Bancalari, E	1
Young, TE	1
Lundquist, LJ	1
Chesler, E	1
Weir, EK	1
Brown, SE	1
Linden, GS	1
King, RR	1
Blair, GP	1
Stansbury, DW	1
Light, RW	1
Scherer, R	1
Wendt, M	1
Schneider, U	1
Kober, S	1
Lawin, P	1
Cheung, JY	1
Leaf, A	1
Bonventre, JV	1
Dubinsky, B	1
Sierchio, JN	1
Temple, DE	1
Ritchie, DM	1
Rosenberger, LB	1
Jacobs, LW	1
Stanton, HC	1
Kovách, AG	3
Dóra, E	2
Ozaki, H	1
Kishimoto, T	1
Chihara, S	1
Umeno, H	1
Urakawa, N	1
Stanbrook, HS	1
Morris, KG	1
McMurtry, IF	6
Higgins, TJ	1
Allsopp, D	1
Bailey, PJ	1
Szedlacsek, S	1
Koller, A	1
Doorey, AJ	1
Barry, WH	1
Kraynack, BJ	1
Gintautas, J	1
Kraynack, LL	1
Havasi, G	1
Watanabe, Y	1
Carbonin, P	1
Di Gennaro, M	1
Valle, R	1
Weisz, AM	1
Gilmour, RF	1
Zipes, DP	1
Rounds, S	1
Cornfield, DN	1
Stevens, T	1
Abman, SH	1
Rodman, DM	1
Savineau, JP	1
Gonzalez de la Fuente, P	1
Marthan, R	1
Semama, D	1
Heumann, C	1
Guignard, JP	1
Hisatome, I	1
Arita, M	1
Wetzels, JF	1
Yu, L	1
Wang, X	1
Kribben, A	1
Burke, TJ	1
Schrier, RW	2
Leesar, MA	1
Martyn, R	1
Talley, JD	1
Frumin, H	1
Randall, MD	1
Griffith, TM	1
Salvaterra, CG	1
Goldman, WF	1
Lee, JJ	1
Boulanger, CM	1
Kirchengast, M	1
Vanhoutte, PM	2
Sanotskaia, NV	1
Matsievskiĭ, DD	1
Kurambaev, IaK	1
Safonov, VA	1
Marquez, MT	1
Consolini, A	1
Bonazzola, P	1
Ponce-Hornos, JE	1
Tenthorey, D	1
de Ribaupierre, Y	1
Kucera, P	1
Raddatz, E	1
Priest, RM	1
Robertson, TP	2
Leach, RM	1
Ward, JP	2
Lee, YH	1
Seo, JH	1
Kang, BS	1
Hague, D	1
Aaronson, PI	1
De Crescenzo, V	1
Dubuis, E	1
Constantin, S	1
Rebocho, M	1
Girardin, C	1
Bonnet, P	1
Vandier, C	1
Nayler, WG	3
Yepez, CE	1
Poole-Wilson, PA	1
Schurek, HJ	1
Aulbert, E	1
Ebel, H	1
Ferrari, R	1
Bongrani, S	1
Fassold, E	1
Yepez, C	1
Davidson, A	1
McMurtry, I	1
Reeves, JT	4
Will, DH	1
Grover, RF	3
Barer, GR	1
Mohammed, FH	1
Sugget, AJ	1
Grau, A	1
Slade, A	1
Meyer, VU	1
Marten, W	1
Schiffer, W	1
Raff, WK	1
Davidson, AB	1
Tucker, A	1
Zhou, ZN	1
Gu, LM	1
Yuan, F	1
Xiao, Y	1
Wilkie, ME	1
Stevens, CR	1
Cunningham, J	1
Blake, D	1
Pacini, DJ	1
Boachie-Ansah, G	1
Kane, KA	3
Ohdaira, T	1
Kobayashi, T	1
Tanaka, M	1
Chowdhury, MF	1
Ahn, B	1
Masuda, A	1
Sakakibara, Y	1
Honda, Y	1
Zager, RA	1
Bredl, CR	1
Schimpf, BA	1
Konishi, K	1
Utsunomiya, H	1
Hashimoto, H	1
Hirano, M	1
Cartee, GD	1
Briggs-Tung, C	1
Holloszy, JO	1
Demiryurek, AT	1
Wadsworth, RM	2
Poloński, L	2
Polońska, A	2
Tendera, M	2
Wodniecki, J	2
Krzywiecki, A	1
Lockwood, AH	1
Yap, EW	1
Hasan, NM	1
Cundall, RB	1
Adams, GE	1
Yuan, XJ	2
Tod, ML	1
Rubin, LJ	1
Blaustein, MP	1
Zhao, L	1
Adamantidis, MM	1
Caron, JF	1
Dupuis, BA	1
Rumsey, WL	1
Wilson, DF	1
Erecińska, M	1
Grably, S	1
Verdys, M	1
Rossi, A	1
Cai, YN	1
Neubauer, S	1
Ingwall, JS	1
Bhattacharyya, ML	1
Acharya, S	1
Lee, SL	1
Dunn, J	1
Yu, FS	1
Fanburg, BL	1
Long, GR	1
Filuk, R	1
Balakumar, M	1
Easton, PA	1
Anthonisen, NR	1
Kjaeve, J	1
Bjertnaes, LJ	1
Kwan, YW	1
Alvarez, J	1
Rousseau, G	1
Dorticós, F	1
Morlans, J	1
Urbanics, R	1
Leitold, M	1
Hader, S	1
Escoubet, B	2
Griffaton, G	2
Lechat, P	2
Barrett, JA	1
DePaul Lynch, V	1
Balkon, J	1
Smith, RD	1
Wolf, PS	1
Cartheuser, CF	2
Douglas, AR	1
Moore-Gillon, JC	1
Sheldon, JW	1
Cameron, IR	2
Brezis, M	1
Shina, A	1
Kidroni, G	1
Epstein, FH	1
Rosen, S	1
Takeo, S	1
Tanonaka, K	1
Tazuma, Y	1
Fukao, N	1
Yoshikawa, C	1
Fukumoto, T	1
Tanaka, T	1
Pudelski, J	1
Kardaszewicz, P	1
Treacher, DF	1
Douglas, A	1
Jones, A	1
Bateman, NT	1
Bradley, RD	1
Samuel, JL	1
McGonigle, RJ	1
Brookins, J	1
Pegram, BL	1
Fisher, JW	1
Mårtensson, L	1
Davoust, N	1
Anno, T	1
Kodama, I	1
Shibata, S	1
Toyama, J	1
Yamada, K	1
Schwertschlag, U	1
Wilson, P	1
Kano, T	1
Nishi, K	1
Smallbone, BW	1
Davies, BJ	1
Noulty, EJ	1
Pisters, LL	1
Taylor, NE	1
McDonald, JW	1
Goligorsky, MS	1
Chaimovitz, C	1
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Rapoport, J	1
Sharony, Y	1
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Salama, G	1
Lombardi, R	1
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Packer, M	1
Asano, T	1
Shigenobu, K	1
Kasuya, Y	1
Chapman, RW	1
Chappell, SP	1
Lewis, MJ	1
Henderson, AH	1
Phillis, JW	1
DeLong, RE	1
Towner, JK	1
Downing, SE	1
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Heboid, G	1
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Meisel, P	1
Urbaszek, W	1
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Haas, H	3
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Fleckenstein, A	1
Schmitt, G	1