verapamil has been researched along with Glioma in 37 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| " As a novel type of nano-radiosensitizer, silver nanoparticles (AgNPs) have shown promising radiosensitizing properties in the radiotherapy of glioma, but their ability to efficiently enter and accumulate in tumor cells needs to be improved." | 8.02 | Increasing the accumulation of aptamer AS1411 and verapamil conjugated silver nanoparticles in tumor cells to enhance the radiosensitivity of glioma. ( Cao, Y; Chen, W; Li, D; Liu, P; Ma, J; Yang, H; Zhao, J, 2021) |
| "The effects of chronic treatment with antidepressants, verapamil, or lithium on serotonin (5-HT)-induced Ca2+ increase were investigated in single C6BU-1 glioma cells with digital imaging microscopy." | 7.69 | Chronic treatment with antidepressants, verapamil, or lithium inhibits the serotonin-induced intracellular calcium response in individual C6 rat glioma cells. ( Kagaya, A; Uchitomi, Y; Yamaji, T; Yamawaki, S; Yokota, N, 1997) |
| "The action of verapamil, /+/-D600 and nisoldipine on the inward calcium current (ICa) was studied in mouse neuroblastoma x rat glioma hybrid cells of the line 108CC5 under voltage clamp conditions by means of a suction pipette method." | 7.67 | Inhibition of calcium channels in neuroblastoma x glioma hybrid cells by verapamil, D600, diltiazem and nisoldipine. ( Bodewei, R; Hering, S; Schubert, B; Wollenberger, A, 1987) |
| " As a novel type of nano-radiosensitizer, silver nanoparticles (AgNPs) have shown promising radiosensitizing properties in the radiotherapy of glioma, but their ability to efficiently enter and accumulate in tumor cells needs to be improved." | 4.02 | Increasing the accumulation of aptamer AS1411 and verapamil conjugated silver nanoparticles in tumor cells to enhance the radiosensitivity of glioma. ( Cao, Y; Chen, W; Li, D; Liu, P; Ma, J; Yang, H; Zhao, J, 2021) |
| "The effects of chronic treatment with antidepressants, verapamil, or lithium on serotonin (5-HT)-induced Ca2+ increase were investigated in single C6BU-1 glioma cells with digital imaging microscopy." | 3.69 | Chronic treatment with antidepressants, verapamil, or lithium inhibits the serotonin-induced intracellular calcium response in individual C6 rat glioma cells. ( Kagaya, A; Uchitomi, Y; Yamaji, T; Yamawaki, S; Yokota, N, 1997) |
| "The action of verapamil, /+/-D600 and nisoldipine on the inward calcium current (ICa) was studied in mouse neuroblastoma x rat glioma hybrid cells of the line 108CC5 under voltage clamp conditions by means of a suction pipette method." | 3.67 | Inhibition of calcium channels in neuroblastoma x glioma hybrid cells by verapamil, D600, diltiazem and nisoldipine. ( Bodewei, R; Hering, S; Schubert, B; Wollenberger, A, 1987) |
| "The effects of 2 specific calcium channel blockers, verapamil and nimodipine, on the proliferation of human glioma tumour cells were investigated in vitro." | 3.67 | Inhibitory effect of calcium channel blockers on proliferation of human glioma cells in vitro. ( Kunert-Radek, J; Lyson, K; Pawlikowski, M; Radek, A; Stepien, H, 1989) |
| "Membrane-modifying agents such as reserpine, calcium antagonists (nicardipine, verapamil) and calmodulin inhibitor (trifluoperazine) were found to enhance the cytotoxicity of ACNU in vitro and in vivo in ACNU-resistant C 6 (C 6/ACNU) glioma." | 3.67 | [Possibility of overcoming of ACNU resistance in an ACNU-resistant subline of C6 rat glioma]. ( Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T, 1986) |
| "Pretreatment with verapamil, a voltage-dependent Ca2+ channel inhibitor, also blocks both the sustained [Ca2+]i elevation and arachidonate liberation without altering peak intracellular Ca2+ release." | 1.28 | Receptor-stimulated phospholipase A2 activation is coupled to influx of external calcium and not to mobilization of intracellular calcium in C62B glioma cells. ( Brooks, RC; Lapetina, EG; McCarthy, KD; Morell, P, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (35.14) | 18.7374 |
| 1990's | 18 (48.65) | 18.2507 |
| 2000's | 3 (8.11) | 29.6817 |
| 2010's | 2 (5.41) | 24.3611 |
| 2020's | 1 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, J | 1 |
| Li, D | 1 |
| Ma, J | 1 |
| Yang, H | 1 |
| Chen, W | 1 |
| Cao, Y | 1 |
| Liu, P | 1 |
| Ham, SW | 1 |
| Jeon, HY | 1 |
| Kim, H | 1 |
| Fong, D | 1 |
| Yeh, A | 1 |
| Naftalovich, R | 1 |
| Choi, TH | 1 |
| Chan, MM | 1 |
| Arbab, AS | 1 |
| Ueki, J | 1 |
| Koizumi, K | 1 |
| Araki, T | 1 |
| Bähr, O | 1 |
| Rieger, J | 1 |
| Duffner, F | 1 |
| Meyermann, R | 1 |
| Weller, M | 1 |
| Wick, W | 1 |
| Atlas, D | 1 |
| Adler, M | 1 |
| Abe, T | 1 |
| Koike, K | 1 |
| Ohga, T | 1 |
| Kubo, T | 1 |
| Wada, M | 1 |
| Kohno, K | 1 |
| Mori, T | 1 |
| Hidaka, K | 1 |
| Kuwano, M | 1 |
| Ichida, S | 1 |
| Wada, T | 1 |
| Nakazaki, S | 1 |
| Matsuda, N | 1 |
| Kishino, H | 1 |
| Akimoto, T | 1 |
| Chueh, SH | 1 |
| Kao, LS | 1 |
| Yamaji, T | 3 |
| Kagaya, A | 3 |
| Okamoto, Y | 2 |
| Hayashi, T | 2 |
| Nagaoka, I | 1 |
| Motohashi, N | 2 |
| Yamawaki, S | 3 |
| Lo, TM | 1 |
| Thayer, SA | 1 |
| Matsukado, K | 1 |
| Ikezaki, K | 1 |
| Nomura, T | 1 |
| Fukui, M | 1 |
| Kowtha, VC | 1 |
| Bryant, HJ | 1 |
| Krauthamer, V | 1 |
| Iwasa, KH | 1 |
| Stenger, DA | 1 |
| Ducharme, J | 1 |
| Abdullah, S | 1 |
| Wainer, IW | 1 |
| Uchitomi, Y | 1 |
| Yokota, N | 1 |
| Hu, Q | 1 |
| Huang, F | 1 |
| Shi, Y | 1 |
| Gérard, V | 1 |
| Rouzaire-Dubois, B | 1 |
| Dilda, P | 1 |
| Dubois, JM | 1 |
| Joshi, PG | 1 |
| Mishra, S | 1 |
| Saqr, HE | 1 |
| Guan, Z | 1 |
| Yates, AJ | 1 |
| Stokes, BT | 1 |
| Andersson, U | 1 |
| Grankvist, K | 1 |
| Bergenheim, AT | 1 |
| Behnam-Motlagh, P | 1 |
| Hedman, H | 1 |
| Henriksson, R | 1 |
| Huet, S | 2 |
| Schott, B | 1 |
| Robert, J | 2 |
| Henderson, GB | 1 |
| Strauss, BP | 1 |
| George, TP | 1 |
| Cook, HW | 1 |
| Byers, DM | 1 |
| Palmer, FB | 1 |
| Spence, MW | 1 |
| Bowles, AP | 1 |
| Pantazis, CG | 1 |
| Wansley, W | 1 |
| Creba, JA | 1 |
| Karobath, M | 1 |
| Bodewei, R | 1 |
| Hering, S | 1 |
| Schubert, B | 1 |
| Wollenberger, A | 1 |
| Brooks, RC | 1 |
| McCarthy, KD | 1 |
| Lapetina, EG | 1 |
| Morell, P | 1 |
| Kunert-Radek, J | 1 |
| Stepien, H | 1 |
| Radek, A | 1 |
| Lyson, K | 1 |
| Pawlikowski, M | 1 |
| Huber, KR | 2 |
| Schmidt, WF | 2 |
| al-Assaad, B | 1 |
| Neuberg, RW | 2 |
| Ettinger, RS | 2 |
| Miwa, N | 1 |
| Sugino, H | 1 |
| Ueno, R | 1 |
| Hayaishi, O | 1 |
| Yoshida, T | 2 |
| Shimizu, K | 2 |
| Ushio, Y | 2 |
| Hayakawa, T | 1 |
| Kato, A | 1 |
| Mogami, H | 2 |
| Sakamoto, Y | 2 |
| Merry, S | 1 |
| Fetherston, CA | 1 |
| Kaye, SB | 1 |
| Freshney, RI | 1 |
| Plumb, JA | 1 |
| Kaba, K | 1 |
| Tani, E | 1 |
| Morimura, T | 1 |
| Matsumoto, T | 1 |
1 trial available for verapamil and Glioma
| Article | Year |
|---|---|
Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity.
Topics: Adult; Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; Brain Neoplasms; Chromatogr | 1996 |
36 other studies available for verapamil and Glioma
| Article | Year |
|---|---|
Increasing the accumulation of aptamer AS1411 and verapamil conjugated silver nanoparticles in tumor cells to enhance the radiosensitivity of glioma.
Topics: Aptamers, Nucleotide; Brain Neoplasms; Cell Line, Tumor; Glioma; Humans; Metal Nanoparticles; Oligod | 2021 |
Verapamil augments carmustine- and irradiation-induced senescence in glioma cells by reducing intracellular reactive oxygen species and calcium ion levels.
Topics: Antineoplastic Combined Chemotherapy Protocols; Calcium; Calcium Channels, L-Type; Carmustine; Cell | 2017 |
Curcumin inhibits the side population (SP) phenotype of the rat C6 glioma cell line: towards targeting of cancer stem cells with phytochemicals.
Topics: Animals; Antineoplastic Agents, Phytogenic; Benzimidazoles; Cell Differentiation; Cell Growth Proces | 2010 |
Effects of extracellular Na+ and Ca2+ ions and Ca2+ channel modulators on the cell-associated activity of 99mTc-MIBI and 99mTc-tetrofosmin in tumour cells.
Topics: Amiloride; Animals; Antineoplastic Agents; Calcium; Calcium Channels; Carcinoma, Lewis Lung; Cell Su | 2003 |
P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Tra | 2003 |
alpha-adrenergic antagonists as possible calcium channel inhibitors.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Calcium; Cell Line; Cell Membran | 1981 |
Chemosensitisation of spontaneous multidrug resistance by a 1,4-dihydropyridine analogue and verapamil in human glioma cell lines overexpressing MRP or MDR1.
Topics: Alkaloids; Antigens, Neoplasm; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, | 1995 |
Specific bindings of [3H](+)PN200-110 and [125I]omega-conotoxin to crude membranes from differentiated NG108-15 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Extracellular ATP stimulates calcium influx in neuroblastoma x glioma hybrid NG108-15 cells.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; Bradykinin; Calcium; Calcium Channel Blo | 1993 |
Intracellular calcium concentration in C6BU-1 rat glioma cells: a single cell study using fluorescence microscopy/video imaging system.
Topics: Animals; Antidepressive Agents; Calcium; Cell Line; Clomipramine; Glioma; Microscopy, Fluorescence; | 1993 |
Refilling the inositol 1,4,5-trisphosphate-sensitive Ca2+ store in neuroblastoma x glioma hybrid NG108-15 cells.
Topics: Animals; Bradykinin; Calcium; Calcium-Transporting ATPases; Dose-Response Relationship, Drug; Flunar | 1993 |
Effect of calcium antagonists on regional cerebral blood flow in transplanted rat brain tumors.
Topics: Analysis of Variance; Animals; Brain; Brain Neoplasms; Calcium Channel Blockers; Cerebrovascular Cir | 1996 |
Spontaneous firing of NG108-15 cells induced by transient exposure to ammonium chloride.
Topics: Amiloride; Ammonium Chloride; Animals; Cell Differentiation; Cell Membrane; Glioma; Hybrid Cells; Hy | 1996 |
Effects of clomipramine and verapamil on 5-HT-induced intracellular calcium changes in individual C6 rat glioma cells.
Topics: Animals; Calcium; Clomipramine; Dose-Response Relationship, Drug; Glioma; Rats; Serotonin; Time Fact | 1996 |
Chronic treatment with antidepressants, verapamil, or lithium inhibits the serotonin-induced intracellular calcium response in individual C6 rat glioma cells.
Topics: Animals; Antidepressive Agents; Calcium; Calcium Channel Blockers; Citalopram; Clomipramine; Drug In | 1997 |
Inhibition of Toosendanin on the delayed rectifier potassium current in neuroblastoma x glioma NG108-15 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Alterations of ionic membrane permeabilities in multidrug-resistant neuroblastoma x glioma hybrid cells.
Topics: Animals; Antineoplastic Agents; Cell Differentiation; Cell Membrane Permeability; Cell Size; Chlorid | 1998 |
A novel type of Ca2+ channel in U-87 MG cells activated by anti-galactocerebroside.
Topics: Calcium; Calcium Channel Blockers; Calcium Channels; Cations, Divalent; Galactosylceramides; Glioma; | 1998 |
Mechanisms through which PDGF alters intracellular calcium levels in U-1242 MG human glioma cells.
Topics: Becaplermin; Brain Neoplasms; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium | 1999 |
Rapid induction of long-lasting drug efflux activity in brain vascular endothelial cells but not malignant glioma following irradiation.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2002 |
P-glycoprotein overexpression cannot explain the complete doxorubicin-resistance phenotype in rat glioblastoma cell lines.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Divisio | 1992 |
Evidence for cAMP and cholate extrusion in C6 rat glioma cells by a common anion efflux pump.
Topics: Animals; Antimycin A; Biological Transport, Active; Cholic Acids; Cyclic AMP; Glioma; Isoproterenol; | 1991 |
Inhibition of phosphatidylcholine and phosphatidylethanolamine biosynthesis by cytochalasin B in cultured glioma cells: potential regulation of biosynthesis by Ca(2+)-dependent mechanisms.
Topics: Animals; Biological Transport, Active; Calcium; Carbon Radioisotopes; Cell Line; Choline; Cytochalas | 1991 |
Use of verapamil to enhance the antiproliferative activity of BCNU in human glioma cells: an in vitro and in vivo study.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Division; Drug Screening Assays, Antitumor; Fluorescent D | 1990 |
The effect of dihydropyridine calcium agonists and antagonists on neuronal voltage sensitive calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1986 |
The reversal of doxorubicin resistance by verapamil is not due to an effect on calcium channels.
Topics: Animals; Barium; Calcium; Cell Line; Doxorubicin; Drug Resistance; Glioma; Ion Channels; Manganese; | 1988 |
Inhibition of calcium channels in neuroblastoma x glioma hybrid cells by verapamil, D600, diltiazem and nisoldipine.
Topics: Animals; Calcium; Calcium Channel Blockers; Diltiazem; Gallopamil; Glioma; Ion Channels; Neuroblasto | 1987 |
Receptor-stimulated phospholipase A2 activation is coupled to influx of external calcium and not to mobilization of intracellular calcium in C62B glioma cells.
Topics: Acetylcholine; Animals; Benzofurans; Calcium; Cell Line; Enzyme Activation; Fluorescent Dyes; Fura-2 | 1989 |
Inhibitory effect of calcium channel blockers on proliferation of human glioma cells in vitro.
Topics: Calcium; Calcium Channel Blockers; Cell Division; Glioma; Humans; Nimodipine; Thymidine; Tumor Cells | 1989 |
Human tumor cells resistant to verapamil.
Topics: Cell Cycle; Cell Division; Cell Line; Cerebellar Neoplasms; Doxorubicin; Drug Resistance; Glioma; Hu | 1989 |
Prostaglandin induces Ca2+ influx and cyclic GMP formation in mouse neuroblastoma X rat glioma hybrid NG108-15 cells in culture.
Topics: Aminoquinolines; Animals; Calcium; Cyclic GMP; Diltiazem; Dinoprost; Dinoprostone; Fluorescent Dyes; | 1988 |
Antiproliferative effect of verapamil alone on brain tumor cells in vitro.
Topics: Calcium; Cell Cycle; Cell Division; Dose-Response Relationship, Drug; Glioma; Humans; In Vitro Techn | 1988 |
[Mechanism and overcoming of resistance in ACNU-resistant sublines of rat brain tumors].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Membrane Permeability; Drug Resistance; Glioma | 1986 |
[Possibility of overcoming of ACNU resistance in an ACNU-resistant subline of C6 rat glioma].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line; Cells, Cultured; Drug Resistance; Drug T | 1986 |
Resistance of human glioma to adriamycin in vitro: the role of membrane transport and its circumvention with verapamil.
Topics: Biological Transport; Cell Line; Cell Survival; Doxorubicin; Drug Resistance; Drug Synergism; Glioma | 1986 |
Potentiation of vincristine effect in human and murine gliomas by calcium channel blockers or calmodulin inhibitors.
Topics: Animals; Brain Neoplasms; Calcium Channel Blockers; Calmodulin; Drug Synergism; Glioma; Humans; In V | 1985 |