verapamil has been researched along with ATLL in 8 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Homoharringtonine (HHT) is a new drug with antileukemic activity which is currently tested for treatment of acute and chronic leukemias, either alone or in combination with other agents." | 1.29 | MDR-related P170-glycoprotein modulates cytotoxic activity of homoharringtonine. ( Baccarani, M; Candoni, A; Damiani, D; Marie, JP; Melli, C; Michelutti, A; Michieli, MG; Russo, D; Zhou, DC; Zittoun, R, 1995) |
| "Verapamil (VRP) is an effective modulator of P170-associated multidrug resistance (MDR), but its clinical application is limited by cardiovascular side-effects." | 1.29 | D-verapamil downmodulates P170-associated resistance to doxorubicin, daunorubicin and idarubicin. ( Baccarani, M; Cerno, M; Damiani, D; Melli, C; Michelutti, A; Michieli, M, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (75.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Majumder, S | 1 |
| Dutta, P | 1 |
| Mukherjee, P | 1 |
| Datta, ER | 1 |
| Efferth, T | 1 |
| Bhattacharya, S | 1 |
| Choudhuri, SK | 1 |
| Medeiros, BC | 1 |
| Landau, HJ | 1 |
| Morrow, M | 1 |
| Lockerbie, RO | 1 |
| Pitts, T | 1 |
| Eckhardt, SG | 1 |
| Frey, T | 1 |
| Yue, S | 1 |
| Haugland, RP | 1 |
| Russo, D | 1 |
| Michelutti, A | 2 |
| Melli, C | 2 |
| Damiani, D | 2 |
| Michieli, MG | 1 |
| Candoni, A | 1 |
| Zhou, DC | 1 |
| Marie, JP | 1 |
| Zittoun, R | 1 |
| Baccarani, M | 2 |
| Jachez, B | 1 |
| Loor, F | 1 |
| Michieli, M | 1 |
| Cerno, M | 1 |
| Johnstone, RW | 1 |
| Cretney, E | 1 |
| Smyth, MJ | 1 |
| Osann, K | 1 |
| Sweet, P | 1 |
| Slater, LM | 1 |
8 other studies available for verapamil and ATLL
| Article | Year |
|---|---|
Reversal of drug resistance in P-glycoprotein-expressing T-cell acute lymphoblastic CEM leukemia cells by copper N-(2-hydroxy acetophenone) glycinate and oxalyl bis (N-phenyl) hydroxamic acid.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzeneacetami | 2006 |
The farnesyl transferase inhibitor, tipifarnib, is a potent inhibitor of the MDR1 gene product, P-glycoprotein, and demonstrates significant cytotoxic synergism against human leukemia cell lines.
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium C | 2007 |
Dyes providing increased sensitivity in flow-cytometric dye-efflux assays for multidrug resistance.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Burkitt Lymphoma; Calcium Channel | 1995 |
MDR-related P170-glycoprotein modulates cytotoxic activity of homoharringtonine.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colonic Neoplasms; Cyclospo | 1995 |
Atypical multi-drug resistance (MDR): low sensitivity of a P-glycoprotein-expressing human T lymphoblastoid MDR cell line to classical P-glycoprotein-directed resistance-modulating agents.
Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Membe | 1993 |
D-verapamil downmodulates P170-associated resistance to doxorubicin, daunorubicin and idarubicin.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Surv | 1993 |
P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamil | 1999 |
Synergistic interaction of cyclosporin A and verapamil on vincristine and daunorubicin resistance in multidrug-resistant human leukemia cells in vitro.
Topics: Cyclosporine; Daunorubicin; Drug Resistance; Drug Synergism; Humans; Kinetics; Leukemia-Lymphoma, Ad | 1992 |