uric acid and Sepsis
uric acid has been researched along with Sepsis in 40 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the antioxidant actions of indirect bilirubin and uric acid on outcomes of sepsis-associated AKI." | 8.12 | Impact of indirect bilirubin and uric acid on outcomes of sepsis-associated acute kidney injury (sAKI). ( Abozenah, M; Bedair, HM; Ebrahim, E; Efat, A; Kassemy, Z; Shoeib, S, 2022) |
| "We conducted an observational study evaluating the association between uric acid, mean platelet volume (MPV), and high-density lipoprotein (HDL) with complications and outcomes of patients with sepsis in a critical care setting." | 7.96 | High-Density Lipoprotein, Mean Platelet Volume, and Uric Acid as Biomarkers for Outcomes in Patients With Sepsis: An Observational Study. ( Chiou, SH; Montero-Chacón, LB; Padilla-Cuadra, JI; Torrealba-Acosta, G, 2020) |
| "To determine the role of mean platelet volume (MPV) and uric acid levels in the diagnosis of neonatal sepsis (NS)." | 7.80 | Mean platelet volume and uric acid levels in neonatal sepsis. ( Aydın, B; Beken, S; Dilli, D; Karadağ, N; Okumuş, N; Zenciroğlu, A, 2014) |
| " Moreover, a mouse model of sepsis was established, and serum alanine transaminase, uric acid, tissue H-FABP, myeloperoxidase, superoxide dismutase activity and histological alterations in lung and intestine were investigated." | 7.75 | Heart-type fatty acid-binding protein is a useful marker for organ dysfunction and leptin alleviates sepsis-induced organ injuries by restraining its tissue levels. ( Hao, XH; Lin, J; Wang, LH; Xue, H; Yan, GT; Zhang, K, 2009) |
| "To explore the effect of ethyl pyruvate (EP) and alkaline phosphatase (ALP) on injuries of sepsis and the mechanism involved." | 7.75 | [Effects of ethyl pyruvate on injuries of sepsis in mice]. ( Deng, ZH; Lin, J; Ti, DD; Wang, LH; Xue, H; Yan, GT, 2009) |
| "In this research, the role of leptin on sepsis-induced organ dysfunction was evaluated." | 7.74 | Leptin protects vital organ functions after sepsis through recovering tissue myeloperoxidase activity: an anti-inflammatory role resonating with indomethacin. ( Hao, XH; Lin, J; Wang, LH; Xue, H; Yan, GT; Zhang, K, 2007) |
| "To detect the effect of sepsis on renal function and corresponding enzymes in mice, and to explore the role of leptin in acute inflammation." | 7.73 | [Leptin protects sepsis-induced renal injury and research for its mechanism]. ( Hao, XH; Lin, J; Wang, LH; Xue, H; Yan, GT; Zhang, K, 2006) |
| " Based on the first serum uric acid level within 24 h of admission to the ICU, patients were divided into groups with or without hyperuricemia, and the incidence of AKI within seven days of ICU admission was compared between the two groups." | 4.31 | Association between hyperuricemia and acute kidney injury in critically ill patients with sepsis. ( Gong, CL; Jiang, YX; Liu, FG; Shi, YL; Tang, Y; Xie, KQ; Yi, Y; Zhou, HW; Zhou, JW, 2023) |
| " We observed higher levels of serum uric acid levels in patients with severe sepsis." | 4.12 | Hyperuricemia as an Early Marker in Predicting Mortality and Morbidity in Patients with Sepsis. ( Maldar, A, 2022) |
| "To evaluate the antioxidant actions of indirect bilirubin and uric acid on outcomes of sepsis-associated AKI." | 4.12 | Impact of indirect bilirubin and uric acid on outcomes of sepsis-associated acute kidney injury (sAKI). ( Abozenah, M; Bedair, HM; Ebrahim, E; Efat, A; Kassemy, Z; Shoeib, S, 2022) |
| "We conducted an observational study evaluating the association between uric acid, mean platelet volume (MPV), and high-density lipoprotein (HDL) with complications and outcomes of patients with sepsis in a critical care setting." | 3.96 | High-Density Lipoprotein, Mean Platelet Volume, and Uric Acid as Biomarkers for Outcomes in Patients With Sepsis: An Observational Study. ( Chiou, SH; Montero-Chacón, LB; Padilla-Cuadra, JI; Torrealba-Acosta, G, 2020) |
| "To determine the role of mean platelet volume (MPV) and uric acid levels in the diagnosis of neonatal sepsis (NS)." | 3.80 | Mean platelet volume and uric acid levels in neonatal sepsis. ( Aydın, B; Beken, S; Dilli, D; Karadağ, N; Okumuş, N; Zenciroğlu, A, 2014) |
| " Moreover, a mouse model of sepsis was established, and serum alanine transaminase, uric acid, tissue H-FABP, myeloperoxidase, superoxide dismutase activity and histological alterations in lung and intestine were investigated." | 3.75 | Heart-type fatty acid-binding protein is a useful marker for organ dysfunction and leptin alleviates sepsis-induced organ injuries by restraining its tissue levels. ( Hao, XH; Lin, J; Wang, LH; Xue, H; Yan, GT; Zhang, K, 2009) |
| "To explore the effect of ethyl pyruvate (EP) and alkaline phosphatase (ALP) on injuries of sepsis and the mechanism involved." | 3.75 | [Effects of ethyl pyruvate on injuries of sepsis in mice]. ( Deng, ZH; Lin, J; Ti, DD; Wang, LH; Xue, H; Yan, GT, 2009) |
| "In this research, the role of leptin on sepsis-induced organ dysfunction was evaluated." | 3.74 | Leptin protects vital organ functions after sepsis through recovering tissue myeloperoxidase activity: an anti-inflammatory role resonating with indomethacin. ( Hao, XH; Lin, J; Wang, LH; Xue, H; Yan, GT; Zhang, K, 2007) |
| "To detect the effect of sepsis on renal function and corresponding enzymes in mice, and to explore the role of leptin in acute inflammation." | 3.73 | [Leptin protects sepsis-induced renal injury and research for its mechanism]. ( Hao, XH; Lin, J; Wang, LH; Xue, H; Yan, GT; Zhang, K, 2006) |
| "Uric acid is a major non-enzymatic antioxidant in the blood, and it exerts a protective action on vitamin C." | 1.48 | The Association Between Serum Uric Acid Level and Prognosis in Critically Ill Patients, Uric Acid as a Prognosis Predictor. ( Er, MC; Kucuk, AO; Ozturk, CE; Pehlivanlar-Kucuk, M; Ulger, F, 2018) |
| "Gout is a systemic disorder characterized by hyperuricemia and recurrent arthritis, most involvement of ankles, midfoot joint and first metatarsophalangeal joint, with monosodium urate crystals deposition in synovial fluid and other tissues." | 1.43 | Miliarial gout: a rare presentation of extensive cutaneous tophi. ( Chiang, CP; Hung, TL; Wang, WM, 2016) |
| "TAC, unable to distinguish severe sepsis and septic shock, is unlikely to be a particularly useful outcome measure." | 1.35 | Plasma antioxidant status in septic critically ill patients: a decrease over time. ( Aho, LS; Aube, H; Blettery, B; Doise, JM; Guilland, JC; Quenot, JP; Rochette, L; Vergely, C; Zeller, M, 2008) |
| "Pretreatment with uric acid reduced 3-NT labelling in leukocytes in mesenteric tissues and in neutrophils obtained from peritoneal exudates." | 1.34 | Peroxynitrite mediates the failure of neutrophil migration in severe polymicrobial sepsis in mice. ( Alves-Filho, JC; Celes, MR; Cunha, FQ; Dal-Secco, D; Dalto, VF; Ferreira, SH; Freitas, A; Rossi, MA; Spiller, F; Torres-Dueñas, D, 2007) |
| "Neonates with sepsis are handicapped in terms of their defense mechanism against free radicals." | 1.33 | Lipid peroxidation and antioxidants in neonatal septicemia. ( Basu, S; Bhatia, BD; Das, BK; Kapoor, K, 2006) |
Research
Studies (40)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (30.00) | 18.7374 |
| 1990's | 2 (5.00) | 18.2507 |
| 2000's | 9 (22.50) | 29.6817 |
| 2010's | 8 (20.00) | 24.3611 |
| 2020's | 9 (22.50) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Hao, X | 1 |
| Guo, D | 1 |
| Yuan, X | 1 |
| Xu, B | 1 |
| Liu, S | 1 |
| Zhong, Z | 1 |
| Liu, F | 1 |
| Maldar, A | 1 |
| Mishra, J | 1 |
| Jatav, JK | 1 |
| Efat, A | 1 |
| Shoeib, S | 1 |
| Ebrahim, E | 1 |
| Kassemy, Z | 1 |
| Bedair, HM | 1 |
| Abozenah, M | 1 |
| Yang, M | 1 |
| Shen, P | 1 |
| Xu, L | 1 |
| Kong, M | 1 |
| Yu, C | 2 |
| Shi, Y | 1 |
| Jiang, YX | 1 |
| Gong, CL | 1 |
| Tang, Y | 2 |
| Yi, Y | 1 |
| Liu, FG | 1 |
| Zhou, JW | 1 |
| Shi, YL | 1 |
| Zhou, HW | 1 |
| Xie, KQ | 1 |
| Liu, JJ | 1 |
| Ma, S | 1 |
| He, Z | 1 |
| Gong, C | 1 |
| Liu, X | 1 |
| Huang, Y | 1 |
| Fang, H | 1 |
| Cheng, Y | 1 |
| Liu, Y | 1 |
| Wang, D | 1 |
| Montero-Chacón, LB | 1 |
| Padilla-Cuadra, JI | 1 |
| Chiou, SH | 1 |
| Torrealba-Acosta, G | 1 |
| Pehlivanlar-Kucuk, M | 1 |
| Kucuk, AO | 1 |
| Ozturk, CE | 1 |
| Er, MC | 1 |
| Ulger, F | 1 |
| Zhi, L | 1 |
| Liang, J | 1 |
| Hu, X | 1 |
| Xu, J | 1 |
| Shao, H | 1 |
| Pan, X | 1 |
| Han, C | 1 |
| Aydın, B | 2 |
| Dilli, D | 2 |
| Zenciroğlu, A | 2 |
| Karadağ, N | 2 |
| Beken, S | 2 |
| Okumuş, N | 2 |
| Kartal, Ö | 1 |
| Kartal, AT | 1 |
| Varol, E | 1 |
| Hung, TL | 1 |
| Wang, WM | 1 |
| Chiang, CP | 1 |
| Yan, GT | 4 |
| Lin, J | 4 |
| Hao, XH | 3 |
| Xue, H | 4 |
| Zhang, K | 3 |
| Wang, LH | 4 |
| Deng, ZH | 1 |
| Ti, DD | 1 |
| LANCET, M | 1 |
| FISHER, IL | 1 |
| SEITCHIK, J | 1 |
| SZUTKA, A | 1 |
| ALPER, C | 1 |
| BODA, D | 1 |
| Widholm, O | 1 |
| Kuhlbaeck, B | 1 |
| Kapoor, K | 1 |
| Basu, S | 1 |
| Das, BK | 1 |
| Bhatia, BD | 1 |
| Giovannini, I | 1 |
| Chiarla, C | 1 |
| Giuliante, F | 1 |
| Pallavicini, F | 1 |
| Vellone, M | 1 |
| Ardito, F | 1 |
| Nuzzo, G | 1 |
| Torres-Dueñas, D | 1 |
| Celes, MR | 1 |
| Freitas, A | 1 |
| Alves-Filho, JC | 1 |
| Spiller, F | 1 |
| Dal-Secco, D | 1 |
| Dalto, VF | 1 |
| Rossi, MA | 1 |
| Ferreira, SH | 1 |
| Cunha, FQ | 1 |
| Doise, JM | 1 |
| Aho, LS | 1 |
| Quenot, JP | 1 |
| Guilland, JC | 1 |
| Zeller, M | 1 |
| Vergely, C | 1 |
| Aube, H | 1 |
| Blettery, B | 1 |
| Rochette, L | 1 |
| Lopez Martinez, J | 1 |
| Caparros, T | 1 |
| Perez Picouto, F | 1 |
| Lopez Diez, F | 1 |
| Cereijo, E | 1 |
| Rojas, C | 1 |
| Cadenas, S | 1 |
| Herrero, A | 1 |
| Méndez, J | 1 |
| Barja, G | 1 |
| Mayser, P | 1 |
| Imkampe, A | 1 |
| Winkeler, M | 1 |
| Papavassilis, C | 1 |
| Armour, J | 1 |
| Tyml, K | 1 |
| Lidington, D | 1 |
| Wilson, JX | 1 |
| Malek, RS | 1 |
| Orchard, PJ | 1 |
| Moffet, HL | 1 |
| Hafez, GR | 1 |
| Sondel, PM | 1 |
| Burry, HC | 1 |
| Carl, P | 1 |
| Eisenberger, F | 1 |
| Hofstetter, A | 1 |
| Silver, RT | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Hydrocortisone, Vitamin C and Thiamine for the Treatment of Septic Shock[NCT03380507] | Phase 2/Phase 3 | 106 participants (Actual) | Interventional | 2018-03-17 | Terminated (stopped due to The research is no longer funded and terminated due to futility) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
2 reviews available for uric acid and Sepsis
| Article | Year |
|---|---|
Renal lithiasis: a practical approach.
Topics: Acidosis, Renal Tubular; Adult; Child, Preschool; Cystinuria; Female; Humans; Hypercalcemia; Intesti | 1977 |
The treatment of chronic lymphocytic leukemia.
Topics: Adrenal Cortex Hormones; Alkylating Agents; Anemia; Anemia, Hemolytic, Autoimmune; Anti-Bacterial Ag | 1969 |
Trials
1 trial available for uric acid and Sepsis
| Article | Year |
|---|---|
[Parenteral nutrition in septic patients with acute renal failure in polyuric phase].
Topics: Acute Kidney Injury; Adult; Aged; Amino Acids, Essential; Creatinine; Female; Humans; Male; Middle A | 1980 |
Other Studies
37 other studies available for uric acid and Sepsis
| Article | Year |
|---|---|
The predictive value of cystatin C combined with lactic acid and uric acid in the occurrence of acute kidney injury in sepsis.
Topics: Acute Kidney Injury; Biomarkers; Creatinine; Cystatin C; Humans; Lactic Acid; Predictive Value of Te | 2022 |
Prognostic value of hyperuricemia for patients with sepsis in the intensive care unit.
Topics: Acute Kidney Injury; Adult; Aged; Critical Care; Databases, Factual; Female; Hospital Mortality; Hos | 2022 |
Hyperuricemia as an Early Marker in Predicting Mortality and Morbidity in Patients with Sepsis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Female; Humans; Hyperuricemia; Male; Middle | 2022 |
To Study the Correlation or Association of Serum Uric Acid Level with Morbidities and Mortality in Sepsis Patient and its Prognostic Significance.
Topics: Case-Control Studies; Female; Humans; Intensive Care Units; Male; Middle Aged; Morbidity; Prognosis; | 2022 |
Impact of indirect bilirubin and uric acid on outcomes of sepsis-associated acute kidney injury (sAKI).
Topics: Acute Kidney Injury; Antioxidants; Bilirubin; Creatinine; Humans; Intensive Care Units; Membrane Lip | 2022 |
Theacrine alleviates sepsis-induced acute kidney injury by repressing the activation of NLRP3/Caspase-1 inflammasome.
Topics: Acute Kidney Injury; Animals; Caspase 1; Creatinine; Inflammasomes; Interleukin-18; Lipopolysacchari | 2022 |
Association between hyperuricemia and acute kidney injury in critically ill patients with sepsis.
Topics: Acute Kidney Injury; Adult; China; Critical Illness; Female; Humans; Hyperuricemia; Intensive Care U | 2023 |
Efficacy of Immature Platelet Fraction in Predicting Septic Acute Kidney Injury.
Topics: Acute Kidney Injury; Area Under Curve; Blood Platelets; C-Reactive Protein; Humans; Procalcitonin; S | 2023 |
[Analysis of prognosis risk factors of critically ill patients after cardiac surgery: a consecutive 5-year retrospective study].
Topics: Critical Illness; Humans; Intensive Care Units; Prognosis; Retrospective Studies; Risk Factors; ROC | 2019 |
High-Density Lipoprotein, Mean Platelet Volume, and Uric Acid as Biomarkers for Outcomes in Patients With Sepsis: An Observational Study.
Topics: Acute Kidney Injury; Adult; Aged; APACHE; Biomarkers; Critical Care; Critical Care Outcomes; Female; | 2020 |
The Association Between Serum Uric Acid Level and Prognosis in Critically Ill Patients, Uric Acid as a Prognosis Predictor.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Blood Chemical Analysis; Critical Illness; Female; Healt | 2018 |
The reliability of clinical dynamic monitoring of redox status using a new redox potential (ORP) determination method.
Topics: Abbreviated Injury Scale; Adult; Ascorbic Acid; Blood Chemical Analysis; Burns; Electrochemistry; El | 2013 |
Mean platelet volume and uric acid levels in neonatal sepsis.
Topics: Blood Platelets; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Mean Platelet Vol | 2014 |
Mean platelet volume and uric acid levels in neonatal sepsis: correspondence I.
Topics: Humans; Infant, Newborn, Diseases; Mean Platelet Volume; Platelet Count; Sepsis; Uric Acid | 2015 |
Mean platelet volume and uric acid levels in neonatal sepsis: correspondence II.
Topics: Humans; Infant, Newborn, Diseases; Mean Platelet Volume; Platelet Count; Sepsis; Uric Acid | 2015 |
Mean platelet volume and uric acid levels in neonatal sepsis: authors' reply.
Topics: Humans; Infant, Newborn, Diseases; Mean Platelet Volume; Sepsis; Uric Acid | 2015 |
Miliarial gout: a rare presentation of extensive cutaneous tophi.
Topics: Fatal Outcome; Gout; Humans; Hyperuricemia; Male; Middle Aged; Sepsis; Skin Diseases; Uric Acid | 2016 |
Heart-type fatty acid-binding protein is a useful marker for organ dysfunction and leptin alleviates sepsis-induced organ injuries by restraining its tissue levels.
Topics: Adult; Alanine Transaminase; Animals; Biomarkers; C-Reactive Protein; Fatty Acid Binding Protein 3; | 2009 |
[Effects of ethyl pyruvate on injuries of sepsis in mice].
Topics: Alkaline Phosphatase; Animals; Disease Models, Animal; Intestines; Lactic Acid; Lung; Male; Mice; Py | 2009 |
The value of blood uric acid levels in toxaemia of pregnancy.
Topics: Bacterial Infections; Blood; Female; Humans; Pre-Eclampsia; Pregnancy; Sepsis; Toxemia; Uric Acid | 1956 |
Further studies on the metabolism of N 15-labeled uric acid in normal and toxemic pregnant women.
Topics: Female; Humans; Pre-Eclampsia; Pregnancy; Sepsis; Uric Acid | 1958 |
[DISEASES OF THE INTRACELLULAR SYSTEM IN THE COURSE OF ACUTE METABOLIC DISTURBANCES].
Topics: Blood Chemical Analysis; Cell Biology; Hypernatremia; Hypokalemia; Metabolic Diseases; Nitrogen; Sep | 1964 |
THE PROGNOSIS OF THE FOETUS IN RELATION TO THE SERUM URIC ACID IN TOXAEMIA OF PREGNANCY.
Topics: Bacterial Infections; Blood; Female; Fetus; Humans; Pre-Eclampsia; Pregnancy; Prognosis; Sepsis; Uri | 1965 |
Lipid peroxidation and antioxidants in neonatal septicemia.
Topics: Antioxidants; Case-Control Studies; Catalase; Glutathione Peroxidase; Humans; India; Infant, Newborn | 2006 |
Serum uric acid, creatinine, and the assessment of antioxidant capacity in critical illness.
Topics: Antioxidants; Creatinine; Critical Illness; Humans; Sepsis; Uric Acid | 2006 |
[Leptin protects sepsis-induced renal injury and research for its mechanism].
Topics: Animals; Disease Models, Animal; Kidney; Leptin; Male; Mice; Peroxidase; Random Allocation; Sepsis; | 2006 |
Peroxynitrite mediates the failure of neutrophil migration in severe polymicrobial sepsis in mice.
Topics: Animals; Antioxidants; Cecum; Cell Adhesion; Cell Movement; Cytokines; Disease Models, Animal; Ligat | 2007 |
Leptin protects vital organ functions after sepsis through recovering tissue myeloperoxidase activity: an anti-inflammatory role resonating with indomethacin.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Kidney; Leptin | 2007 |
Plasma antioxidant status in septic critically ill patients: a decrease over time.
Topics: Adult; Aged; Analysis of Variance; Antioxidants; Ascorbic Acid; Bilirubin; Biomarkers; Chromatograph | 2008 |
Endotoxin depletes ascorbate in the guinea pig heart. Protective effects of vitamins C and E against oxidative stress.
Topics: Analysis of Variance; Animals; Antioxidants; Ascorbic Acid; Catalase; Endotoxins; Escherichia coli; | 1996 |
Growth requirements and nitrogen metabolism of Malassezia furfur.
Topics: Allantoin; Amino Acids; Ammonium Chloride; Ammonium Sulfate; Cell Division; Creatine; Creatinine; Cu | 1998 |
Ascorbate prevents microvascular dysfunction in the skeletal muscle of the septic rat.
Topics: Animals; Ascorbic Acid; Capillaries; Carbon Dioxide; Cecum; Endothelium, Vascular; Hemoglobins; Hydr | 2001 |
Pseudomonas sepsis simulating acute promyelocytic leukemia.
Topics: Bone Marrow Examination; Hemoglobins; Hepatomegaly; Humans; Infant; Leukemia, Myeloid, Acute; Leukoc | 1988 |
[Urinary tract infection, hyperuricemia, septicemia, transitory abdominal pain, cerebral accident].
Topics: Aged; Ascites; Cerebrovascular Disorders; Cystitis; Hemiplegia; Humans; Liver Cirrhosis; Male; Prost | 1970 |
Monilial septicaemia in acute leukaemia. Successful treatment in a case complicated by acute uric acid nephropathy.
Topics: Acetazolamide; Adolescent; Amphotericin B; Candidiasis; Humans; Infectious Mononucleosis; Kidney Dis | 1966 |
[Uric acid diathesis and urosepsis].
Topics: Adult; Aged; Cystoscopy; Diabetes Complications; Escherichia coli; Female; Humans; Kidney; Klebsiell | 1972 |
Hypertension, hyperuricemia and iatrogenic disease.
Topics: Aged; Allopurinol; Aortic Diseases; Arteriosclerosis; Brain; Catheterization; Chlorothiazide; Diagno | 1970 |