Page last updated: 2024-10-21

urea and HbS Disease

urea has been researched along with HbS Disease in 114 studies

pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.

Research Excerpts

ExcerptRelevanceReference
"Uric acid level was significantly increased in children with Hb-SS compared to corresponding values in control group (4."1.40Renal function in children suffering from sickle cell disease: challenge of early detection in highly resource-scarce settings. ( Aloni, MN; Ekila, MB; Gini-Ehungu, JL; Lepira, FB; Ngiyulu, RM; Nseka, NM; Nsibu, CN, 2014)
"Haemolysis has features which suggest that it is linked to activation of the pathway termed Psickle."1.39A non-electrolyte haemolysis assay for diagnosis and prognosis of sickle cell disease. ( Browning, JA; Ellory, JC; Gibson, JS; Hannemann, A; Milligan, C; Osei, A; Rees, DC, 2013)
" Hydroxyurea, at the dosage of 500-1000 mg/day, was being administered to 28."1.38Evaluation of renal function in sickle cell disease patients in Brazil. ( Bem, AX; Costa, CM; Costa, R; Daher, EF; Figueiredo Filho, AC; Guedes, AL; Libório, AB; Lopes Filho, AS; Silva Junior, GB; Souza, JH; Vieira, AP, 2012)
"Pain is the leading cause of emergency department visits, hospitalizations, and daily suffering in individuals with sickle cell disease (SCD)."1.37Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease. ( Barabas, ME; Brandow, AM; Hillery, CA; Kerstein, PC; Retherford, D; Stucky, CL; Vilceanu, D; Wandersee, NJ, 2011)
"Urea kinetics were measured on two separate occasions in five adults with normal haemoglobin genotype (HbAA) and in four who were homozygous for sickle cell disease (HbSS)."1.28Urea kinetics: comparison of oral and intravenous dose regimens. ( Forrester, T; Hibbert, JM; Jackson, AA, 1992)
"Uric acid excretion was higher in the sicklers, and so was the mean urine acid to creatinine ratio (0."1.27Effect of dietary nitrogen on urinary excretion of non-protein nitrogen in adolescent sickle cell patients. ( Addae, SK; Apatu, RS; Odonkor, PO; Yamamoto, S, 1984)
"Proteinuria was more common in these patients, and haemoglobin concentrations were much lower than in the 19 patients without renal insufficiency (mean 5."1.26Renal function in patients over 40 with homozygous sickle-cell disease. ( Morgan, AG; Serjeant, GR, 1981)

Research

Studies (114)

TimeframeStudies, this research(%)All Research%
pre-1990100 (87.72)18.7374
1990's5 (4.39)18.2507
2000's2 (1.75)29.6817
2010's6 (5.26)24.3611
2020's1 (0.88)2.80

Authors

AuthorsStudies
Olawale, OO1
Adekanmbi, AF1
Sonuga, AA1
Sonuga, OO1
Akodu, SO1
Ogundeyi, MM1
De Simone, E1
Di Micco, L1
La Manna, G1
Di Iorio, B1
Aloni, MN1
Ngiyulu, RM1
Gini-Ehungu, JL1
Nsibu, CN1
Ekila, MB1
Lepira, FB1
Nseka, NM1
Ozgunes, N1
Oztas, Y1
Unal, S1
Yaman, H1
Hillery, CA1
Kerstein, PC1
Vilceanu, D1
Barabas, ME1
Retherford, D1
Brandow, AM1
Wandersee, NJ1
Stucky, CL1
Silva Junior, GB1
Libório, AB1
Vieira, AP1
Bem, AX1
Lopes Filho, AS1
Figueiredo Filho, AC1
Guedes, AL1
Souza, JH1
Costa, CM1
Costa, R1
Daher, EF1
Milligan, C1
Rees, DC1
Ellory, JC4
Osei, A1
Browning, JA1
Hannemann, A1
Gibson, JS4
Bize, I1
Taher, S1
Brugnara, C1
JOVIN, T1
CHRAMBACH, A1
NAUGHTON, MA1
Joiner, CH1
Rettig, RK1
Jiang, M1
Risinger, M1
Franco, RS1
Bunn, HF2
Alavi, JB1
Chang, H2
Ewert, SM1
Bookchin, RM1
Nagel, RL2
Aluoch, JR1
Odonkor, PO1
Addae, SK2
Yamamoto, S1
Apatu, RS1
Morgan, AG1
Serjeant, GR2
Gail, M1
Beach, J1
Dark, A1
Lewis, R1
Morrow, H1
de Jong, PE1
de Jong-Van Den Berg, TW1
Sewrajsingh, GS1
Schouten, H1
Donker, AJ1
Statius van Eps, LW1
al-Ali, AK1
Ahmed, MA1
Qaw, FS1
al-Fadel Saleh, M1
al-Bashir, A1
Culliford, SJ1
Speake, PF2
Stewart, GW1
Trubowitz, S1
Brewer, GJ2
Dean, J1
Schechter, AN1
Vener, KJ1
Kang, SS1
Benjamin, G1
Wagner, SM1
Bishop, J1
Flanigan, PW1
Bromberg, PA1
Balcerzak, SP1
May, A1
Huehns, ER1
Wong, SC1
Huisman, TH2
Bemis, EL1
Spooner, TR1
Dark, AW1
Hibbert, JM1
Forrester, T1
Jackson, AA3
Badaloo, A1
Jahoor, F1
Landman, JP1
Stevens, MC1
Nalbandian, RM21
Opio, E2
Barnes, PM2
Bessis, M1
Weed, RI1
Paniker, NV1
Ben-Bassat, I1
Beutler, E1
Henry, RL7
Photiades, DP1
Khalil, SA1
Osamo, NO1
Obi, JO1
Coplans, M1
Huntsman, RG1
Lehmann, H1
McCurdy, PR5
Waterman, MR1
Yamaoka, K1
Dahm, L1
Taylor, J1
Cottam, GL1
Amma, EL1
Sproul, GD1
Wong, S1
Pariser, S1
Cerami, A3
Schwartz, E1
Freedman, ML2
Guy, RB1
Rothenberg, SP1
Murayama, M1
Barnhart, MI3
Camp, FR5
Bensinger, TA3
Mahmood, L3
Conrad, ME3
Karayalcin, G1
Imran, M1
Rosner, F1
Lubin, BH1
Oski, FA1
Glader, BE1
Schorr, KA1
Tischer, RG1
Ratner, BD1
Miller, IF1
Scrimgeour, A1
Pearson, HA2
Salomon, MI1
Lerner, R1
Reindorf, C1
Wethers, D1
Tchertkoff, V1
Diamond, LK1
Lipp, EC1
Rudders, RA1
Pisciotta, AV1
Segel, GB1
Feig, SA1
Mentzer, WC1
McCaffrey, RP1
Wells, R1
Shohet, SB1
Nathan, DG1
Muranda, M1
Etcheverry, R1
Becker, P1
Duran, N1
Saavedra, L1
Pemjean, I1
Nichols, BM4
Stehouwer, EJ1
Brody, JI1
Ranney, HM1
Manning, JM2
Gillette, PN1
De Furia, FG1
Miller, DR1
Lusher, JM5
Eyre, JT1
Ashcom, RC1
Black, AV1
Desforges, JF2
Smith, R1
Sugerman, H1
Lubin, B1
Oski, F1
Scott, RB1
Maisels, MJ1
Conte, NF2
Wolf, PL3
Shultz, G1
Anderson, JW2
Agustsson, A1
Diggs, LW1
Lever, AF1
Azizi, E1
Dror, Y1
Wallis, K1
Evans, TN1
Harris, A1
Whitten, CF1
Cheatham, ML1
Brackett, CE1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Abciximab (ReoPro) as a Therapeutic Intervention for Sickle Cell Vaso-Occlusive Pain Crisis[NCT01932554]Phase 20 participants (Actual)Interventional2013-11-30Withdrawn (stopped due to Insufficient recruitment)
Effects of β-hydroxy-β-methyl Butyrate Supplementation and Resistance Exercise on Body Composition, Muscle Strength and Protein Oxidation in Sickle Cell Anaemia.[NCT04001907]24 participants (Anticipated)Interventional2013-04-30Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

18 reviews available for urea and HbS Disease

ArticleYear
[Protein carbamylation: what it is and why it concerns nephrologists].
    Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 2018, Volume: 35, Issue:3

    Topics: Alzheimer Disease; Amino Acids; Amyloidosis; Anemia, Sickle Cell; Animals; Cardiovascular Diseases;

2018
Sickle cell anemia. Pathophysiology and treatment.
    The Medical clinics of North America, 1984, Volume: 68, Issue:3

    Topics: Anemia, Sickle Cell; Antisickling Agents; Azacitidine; Azepines; Blood Transfusion; Cerebrovascular

1984
Comparative evaluation of fifteen anti-sickling agents.
    Blood, 1983, Volume: 61, Issue:4

    Topics: Anemia, Sickle Cell; Antisickling Agents; Aspirin; Azepines; Carbamyl Phosphate; Cyanates; Cystamine

1983
The treatment of sickle cell disease. A historical and chronological literature review of the therapies applied since 1910.
    Tropical and geographical medicine, 1984, Volume: 36, Issue:4

    Topics: Anemia, Sickle Cell; Antisickling Agents; Azepines; Clinical Trials as Topic; Cyanates; Deamino Argi

1984
Pathophysiology of abnormal cell volume in human red cells.
    Contributions to nephrology, 1998, Volume: 123

    Topics: Anemia, Hemolytic, Congenital; Anemia, Sickle Cell; Bicarbonates; Carrier Proteins; Cell Membrane Pe

1998
The management of sickle cell anemia.
    The Medical clinics of North America, 1976, Volume: 60, Issue:5

    Topics: Analgesics, Opioid; Anemia, Sickle Cell; Bacterial Infections; Blood Transfusion; Cholelithiasis; Cy

1976
A view of the current status of antisickling therapy.
    American journal of hematology, 1976, Volume: 1, Issue:1

    Topics: Alkalies; Anemia, Sickle Cell; Antisickling Agents; Calcium; Cyanates; Dose-Response Relationship, D

1976
The structure of normal and pathologic erythrocytes.
    Advances in biological and medical physics, 1973, Volume: 14

    Topics: Agglutination; Anemia, Sickle Cell; Citrates; Computers; Erythrocytes; Erythrocytes, Abnormal; Freez

1973
The treatment of sickle-cell disease.
    Lancet (London, England), 1972, Mar-25, Volume: 1, Issue:7752

    Topics: Anemia, Sickle Cell; Cyanates; Diphosphoglyceric Acids; Erythrocytes; Hemoglobin, Sickle; Hemoglobin

1972
Cyanate as an inhibitor of red-cell sickling.
    The New England journal of medicine, 1972, Oct-19, Volume: 287, Issue:16

    Topics: Anemia, Sickle Cell; Animals; Body Weight; Carbamates; Carbon Isotopes; Cyanates; Dogs; Erythrocytes

1972
Hemoglobinopathies of clinical importance.
    Pediatric clinics of North America, 1972, Volume: 19, Issue:4

    Topics: Anemia, Hemolytic; Anemia, Sickle Cell; Blood Transfusion; Cyanates; Cyanosis; Hemoglobin C; Hemoglo

1972
New drugs in the treatment of sickle cell anemia.
    The American journal of the medical sciences, 1973, Volume: 265, Issue:5

    Topics: Anemia, Sickle Cell; Carbamates; Cyanates; Hemoglobins, Abnormal; Humans; Megestrol; Molecular Confo

1973
Sickle cell crisis.
    The Medical clinics of North America, 1973, Volume: 57, Issue:6

    Topics: Abdomen, Acute; Abortion, Therapeutic; Acidosis; Anemia, Sickle Cell; Bicarbonates; Citrates; Dehydr

1973
Sickle cell hemoglobin: molecular basis of sickling phenomenon theory and therapy.
    CRC critical reviews in biochemistry, 1973, Volume: 1, Issue:4

    Topics: Anemia, Sickle Cell; Cell Membrane; Erythrocytes; Freeze Etching; Haptens; Hemoglobin, Sickle; Hemog

1973
Sickle cell disease: clinical advances by the Murayama molecular hypothesis.
    Military medicine, 1972, Volume: 137, Issue:6

    Topics: Administration, Oral; Adult; Anemia, Sickle Cell; Anesthesia; Automation; Diagnosis, Differential; H

1972
Why can't sickle cell patients concentrate urine?
    Medical times, 1971, Volume: 99, Issue:8

    Topics: Adolescent; Adult; Age Factors; Anemia, Sickle Cell; Child; Child, Preschool; Female; Hemoglobinomet

1971
The critically ill child: sickle cell disease crises and their management.
    Pediatrics, 1971, Volume: 48, Issue:4

    Topics: Abdomen; Acidosis; Anemia, Sickle Cell; Bilirubin; Blood Cell Count; Blood Transfusion; Child; Chole

1971
Treatment of crises in sickle cell anemia.
    The American journal of the medical sciences, 1971, Volume: 261, Issue:6

    Topics: Acid-Base Equilibrium; Anemia, Sickle Cell; Blood Transfusion; Carrier State; Erythrocytes, Abnormal

1971

Trials

6 trials available for urea and HbS Disease

ArticleYear
The treatment of sickle cell disease. A historical and chronological literature review of the therapies applied since 1910.
    Tropical and geographical medicine, 1984, Volume: 36, Issue:4

    Topics: Anemia, Sickle Cell; Antisickling Agents; Azepines; Clinical Trials as Topic; Cyanates; Deamino Argi

1984
A double-blind randomized trial of low-dose oral urea to prevent sickle cell crises.
    Journal of chronic diseases, 1982, Volume: 35, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Anemia, Sickle Cell; Child; Child, Preschool; Clinical Tria

1982
Intravenous urea in treatment of bone-pain crises of sickle-cell disease. A double-blind trial.
    Lancet (London, England), 1972, Jul-22, Volume: 2, Issue:7769

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Blood Urea Nitrogen; Bone Diseases; Child; Clinical Trials a

1972
Editorial: Treatment of sickle-cell crises.
    Lancet (London, England), 1974, Sep-28, Volume: 2, Issue:7883

    Topics: Anemia, Sickle Cell; Bicarbonates; Clinical Trials as Topic; Drug Evaluation; Hexoses; Humans; Infus

1974
Clinical trials of therapy for sickle cell vaso-occlusive crises. Cooperative urea trials group.
    JAMA, 1974, May-27, Volume: 228, Issue:9

    Topics: Alkalies; Anemia, Sickle Cell; Arterial Occlusive Diseases; Bicarbonates; Blood Urea Nitrogen; Evalu

1974
Treatment of sickle cell crisis with urea in invert sugar. A controlled trial. Cooperative urea trials group.
    JAMA, 1974, May-27, Volume: 228, Issue:9

    Topics: Adult; Age Factors; Anemia, Sickle Cell; Blood Urea Nitrogen; Body Weight; Child; Clinical Trials as

1974

Other Studies

91 other studies available for urea and HbS Disease

ArticleYear
Assessment of Renal Function Status in Steady-State Sickle Cell Anaemic Children Using Urine Human Neutrophil Gelatinase-Associated Lipocalin and Albumin:Creatinine Ratio.
    Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2021, Volume: 30, Issue:6

    Topics: Adolescent; Albumins; Albuminuria; Anemia, Sickle Cell; Biomarkers; Case-Control Studies; Child; Chi

2021
Renal function in children suffering from sickle cell disease: challenge of early detection in highly resource-scarce settings.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: Anemia, Sickle Cell; Blood Pressure; Child; Counseling; Creatinine; Democratic Republic of the Congo

2014
Structural modification of plasma albumin in sickle cell anemia.
    Acta haematologica, 2015, Volume: 133, Issue:1

    Topics: Anemia, Sickle Cell; Case-Control Studies; Child; Humans; Protein Conformation; Protein Denaturation

2015
Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease.
    Blood, 2011, Sep-22, Volume: 118, Issue:12

    Topics: Action Potentials; Anemia, Sickle Cell; Animals; Capsaicin; Disease Models, Animal; Female; Humans;

2011
Evaluation of renal function in sickle cell disease patients in Brazil.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2012, Volume: 45, Issue:7

    Topics: Adult; Aged; Anemia, Sickle Cell; Biomarkers; Cohort Studies; Creatinine; Female; Glomerular Filtrat

2012
A non-electrolyte haemolysis assay for diagnosis and prognosis of sickle cell disease.
    The Journal of physiology, 2013, Mar-15, Volume: 591, Issue:6

    Topics: Aldehydes; Anemia, Sickle Cell; Cell Membrane; Cytochalasin B; Erythrocytes, Abnormal; Hematologic T

2013
Regulation of K-Cl cotransport during reticulocyte maturation and erythrocyte aging in normal and sickle erythrocytes.
    American journal of physiology. Cell physiology, 2003, Volume: 285, Issue:1

    Topics: Adult; Anemia, Sickle Cell; Animals; Biological Transport; Cell Count; Cellular Senescence; Erythroc

2003
AN APPARATUS FOR PREPARATIVE TEMPERATURE-REGULATED POLYACRYLAMIDE GEL ELECTROPHORESIS.
    Analytical biochemistry, 1964, Volume: 9

    Topics: Anemia; Anemia, Sickle Cell; Buffers; Electrophoresis; Electrophoresis, Polyacrylamide Gel; Equipmen

1964
Urea stimulation of KCl cotransport induces abnormal volume reduction in sickle reticulocytes.
    Blood, 2007, Feb-15, Volume: 109, Issue:4

    Topics: Anemia, Sickle Cell; Biological Transport; Cell Size; Disulfides; Dithiothreitol; Hemoglobins; Human

2007
Sickle cell disease: advances in the 1970s and challenge in the 1980s.
    The American journal of pediatric hematology/oncology, 1982,Summer, Volume: 4, Issue:2

    Topics: Anemia, Sickle Cell; Cyanates; Diet, Sodium-Restricted; Erythrocytes, Abnormal; Fetal Hemoglobin; Fo

1982
Effect of dietary nitrogen on urinary excretion of non-protein nitrogen in adolescent sickle cell patients.
    Human nutrition. Clinical nutrition, 1984, Volume: 38, Issue:1

    Topics: Adolescent; Ammonia; Anemia, Sickle Cell; Creatinine; Diet; Humans; Male; Nitrogen; Urea; Uric Acid

1984
Renal function in patients over 40 with homozygous sickle-cell disease.
    British medical journal (Clinical research ed.), 1981, Apr-11, Volume: 282, Issue:6271

    Topics: Adult; Anemia, Sickle Cell; Creatinine; Female; Hemoglobins; Humans; Kidney; Kidney Function Tests;

1981
The influence of indomethacin on renal haemodynamics in sickle cell anaemia.
    Clinical science (London, England : 1979), 1980, Volume: 59, Issue:4

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Female; Glomerular Filtration Rate; Humans; Indomethacin; Ki

1980
Uric acid, creatinine and urea in normal, glucose-6-phosphate dehydrogenase-deficient and Hb SS Saudi subjects.
    Acta haematologica, 1995, Volume: 94, Issue:2

    Topics: Anemia, Sickle Cell; Creatinine; Glucosephosphate Dehydrogenase Deficiency; Humans; Saudi Arabia; Si

1995
Effects of urea and oxygen tension on K flux in sickle cells.
    Pflugers Archiv : European journal of physiology, 1998, Volume: 435, Issue:5

    Topics: Anemia, Sickle Cell; Chlorides; Erythrocytes; Hemoglobin, Sickle; Humans; In Vitro Techniques; Ion T

1998
Differential oxygen sensitivity of the K+-Cl- cotransporter in normal and sickle human red blood cells.
    The Journal of physiology, 1998, Aug-15, Volume: 511 ( Pt 1)

    Topics: Anemia, Sickle Cell; Bumetanide; Carboxylic Acids; Carrier Proteins; Chlorides; Egtazic Acid; Enzyme

1998
Detours on the road to successful treatment of sickle cell anemia.
    Perspectives in biology and medicine, 1979,Winter, Volume: 22, Issue:2 Pt 1

    Topics: Anemia, Sickle Cell; Cyanates; Diphosphoglyceric Acids; Erythrocyte Membrane; Hemoglobin, Sickle; Hi

1979
Sickle-cell anemia: molecular and cellular bases of therapeutic approaches (second of three parts).
    The New England journal of medicine, 1978, Oct-12, Volume: 299, Issue:15

    Topics: Anemia, Sickle Cell; Animals; Cyanates; Drug Evaluation; Erythrocyte Membrane; Erythrocytes; Erythro

1978
Measurement of sickling by controlled temperature increase.
    Blood, 1978, Volume: 52, Issue:6

    Topics: Anemia, Sickle Cell; Cyanates; Dithionite; Heterozygote; Homozygote; Humans; Temperature; Urea

1978
Urea and sickle cell anemia.
    Journal of theoretical biology, 1977, Jun-07, Volume: 66, Issue:3

    Topics: Anemia, Sickle Cell; Blood Urea Nitrogen; Diuresis; Hemoglobin, Sickle; Humans; Kidney; Urea; Vasopr

1977
Homoserine inhibition of in vitro sickling of erythrocytes.
    Experimental and molecular pathology, 1975, Volume: 22, Issue:2

    Topics: Anemia, Sickle Cell; Cyanates; Erythrocytes; Gels; Hemoglobin, Sickle; Homoserine; Humans; Macromole

1975
Enhancement of filterability of sickle cells by cyanate: an effect independent of oxygen saturation.
    The Journal of laboratory and clinical medicine, 1975, Volume: 85, Issue:3

    Topics: Adenosine Triphosphate; Anemia, Sickle Cell; Cyanates; Diphosphoglyceric Acids; Erythrocytes; Filtra

1975
The effect of urea on sickling.
    British journal of haematology, 1975, Volume: 30, Issue:1

    Topics: Anemia, Sickle Cell; Erythrocytes; Erythrocytes, Abnormal; Hemoglobin, Sickle; Hemoglobins; Humans;

1975
Viscosity and gelation studies in deer hunting hemoglobins.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1975, Volume: 150, Issue:3

    Topics: Anemia, Sickle Cell; Animals; Blood Viscosity; Cyanates; Deer; Disease Models, Animal; Gels; Hemoglo

1975
Editorial: Optimal vs optional testing for sickle cell disease.
    JAMA, 1975, Nov-24, Volume: 234, Issue:8

    Topics: Anemia, Sickle Cell; Cyanates; Electrophoresis; Genetic Counseling; Humans; Mass Screening; United S

1975
The management of sickle cell patients undergoing surgery.
    The Laryngoscope, 1976, Volume: 86, Issue:4

    Topics: Acidosis, Respiratory; Adenoidectomy; Anemia, Sickle Cell; Blood Protein Electrophoresis; Dehydratio

1976
Urea kinetics: comparison of oral and intravenous dose regimens.
    European journal of clinical nutrition, 1992, Volume: 46, Issue:6

    Topics: Absorption; Administration, Oral; Adolescent; Adult; Anemia, Sickle Cell; Evaluation Studies as Topi

1992
Whole body protein turnover and resting metabolic rate in homozygous sickle cell disease.
    Clinical science (London, England : 1979), 1989, Volume: 77, Issue:1

    Topics: Adult; Ammonia; Anemia, Sickle Cell; Energy Metabolism; Hemoglobin SC Disease; Hemoglobins; Humans;

1989
Urea kinetics in adults with homozygous sickle cell disease.
    European journal of clinical nutrition, 1988, Volume: 42, Issue:6

    Topics: Adult; Anemia, Sickle Cell; Diet; Homozygote; Humans; Hydrolysis; Nitrogen; Sickle Cell Trait; Urea

1988
Treatment and prevention of sickle-cell crisis.
    Lancet (London, England), 1971, Nov-13, Volume: 2, Issue:7733

    Topics: Anemia, Sickle Cell; Blood Urea Nitrogen; Hemoglobins; Humans; Urea

1971
Treatment and prevention of sickle-cell crisis.
    Lancet (London, England), 1972, Apr-22, Volume: 1, Issue:7756

    Topics: Anemia, Sickle Cell; Humans; Structure-Activity Relationship; Urea

1972
Intravenous urea in management of sickle-cell crisis.
    Lancet (London, England), 1972, Oct-07, Volume: 2, Issue:7780

    Topics: Anemia, Sickle Cell; Humans; Injections, Intravenous; Urea

1972
Intravenous urea in management of sickle-cell crisis.
    Lancet (London, England), 1972, Oct-14, Volume: 2, Issue:7781

    Topics: Anemia, Sickle Cell; Child; Humans; Injections, Intravenous; Urea

1972
Treatment and prevention of sickle-cell crisis.
    Lancet (London, England), 1971, Dec-04, Volume: 2, Issue:7736

    Topics: Administration, Oral; Anemia, Sickle Cell; Humans; Urea

1971
Evaluation of sickle hemoglobin and desickling agents by falling ball viscometry.
    The Journal of laboratory and clinical medicine, 1972, Volume: 80, Issue:2

    Topics: 6-Phytase; Anemia, Sickle Cell; Aspirin; Blood Viscosity; Carbamates; Cyanates; Drug Storage; Fructo

1972
Letter: Urea and the sickle cell crisis.
    JAMA, 1974, Sep-02, Volume: 229, Issue:10

    Topics: Acute Disease; Anemia, Sickle Cell; Humans; Injections, Intravenous; Urea

1974
The in-vitro inhibition of erythrocyte sickling by Biuret.
    Blut, 1974, Volume: 29, Issue:3

    Topics: Amides; Anemia, Sickle Cell; Erythrocytes; Humans; Urea

1974
Sickle cell problems - anaesthetics.
    Proceedings of the Royal Society of Medicine, 1974, Volume: 67, Issue:10

    Topics: Anemia, Sickle Cell; Anesthesia, General; Blood Transfusion; Blood Viscosity; Dextrans; Electrophore

1974
Treatment of sickle-cell disease.
    British journal of haematology, 1974, Volume: 28, Issue:4

    Topics: Anemia, Sickle Cell; Anesthesia; Anticoagulants; Aspirin; Bicarbonates; Blood; Blood Flow Velocity;

1974
Letter: Sickle cell crisis and urea.
    JAMA, 1974, Dec-04, Volume: 230, Issue:10

    Topics: Anemia, Sickle Cell; Humans; Methods; Urea

1974
Noncovalent modification of deoxyhemoglobin S solubility and erythrocyte sickling.
    Proceedings of the National Academy of Sciences of the United States of America, 1974, Volume: 71, Issue:6

    Topics: Ammonium Sulfate; Anemia, Sickle Cell; Buffers; Dimethyl Sulfoxide; Dimethylformamide; Dioxins; Etha

1974
Mechanism of sickling in deer erythrocytes.
    Annals of the New York Academy of Sciences, 1974, Nov-29, Volume: 241, Issue:0

    Topics: Amino Acid Sequence; Amino Acids; Anemia, Sickle Cell; Animals; Cyanates; Deer; Diphosphoglyceric Ac

1974
Oral urea treatment of hematuria in sickle-cell trait.
    New York state journal of medicine, 1974, Volume: 74, Issue:12

    Topics: Administration, Oral; Adult; Anemia, Sickle Cell; Female; Hematuria; Humans; Sickle Cell Trait; Urea

1974
Urea therapy of sickle cell anemia.
    Clinical chemistry, 1972, Volume: 18, Issue:12

    Topics: Anemia, Sickle Cell; Blood Urea Nitrogen; Injections, Intravenous; Urea

1972
Oral urea in sickle-cell disease.
    Annals of internal medicine, 1972, Volume: 77, Issue:4

    Topics: Administration, Oral; Anemia, Sickle Cell; Humans; Urea

1972
The effect of oral urea administration on red cell survival in sickle cell disease.
    The American journal of the medical sciences, 1972, Volume: 264, Issue:4

    Topics: Administration, Oral; Adult; Anemia, Sickle Cell; Blood Urea Nitrogen; Blood Volume; Chromium Isotop

1972
Priapism in sickle cell disease: report of five cases.
    The American journal of the medical sciences, 1972, Volume: 264, Issue:4

    Topics: Adult; Anemia, Sickle Cell; Blood Transfusion; Chlorpromazine; Codeine; Diethylstilbestrol; Drainage

1972
More on urea and sickling.
    The New England journal of medicine, 1972, Nov-16, Volume: 287, Issue:20

    Topics: Administration, Oral; Anemia, Sickle Cell; Blood Transfusion; Humans; Urea

1972
Urea therapy in sickle-cell disease.
    Annals of internal medicine, 1973, Volume: 78, Issue:2

    Topics: Anemia, Sickle Cell; Humans; Urea

1973
Oral urea therapy in children with sickle cell anemia.
    The Journal of pediatrics, 1973, Volume: 82, Issue:2

    Topics: Administration, Oral; Adolescent; Anemia, Sickle Cell; Child; Child, Preschool; Erythrocyte Count; E

1973
Intravascular hemolysis associated with intravenous urea infusions in normal individuals.
    Blood, 1973, Volume: 41, Issue:3

    Topics: Adult; Anemia, Sickle Cell; Carbon Monoxide; Cell Membrane; Erythrocytes; Erythrocytes, Abnormal; He

1973
New treatments for sickle cell disease.
    The Medical letter on drugs and therapeutics, 1973, Feb-16, Volume: 15, Issue:4

    Topics: Alkalies; Anemia, Sickle Cell; Blood Transfusion; Cyanates; Humans; Urea

1973
Evaluation of several methods used in the detection of sickle cell disease.
    The American journal of medical technology, 1973, Volume: 39, Issue:3

    Topics: Anemia, Sickle Cell; Autoanalysis; Electrophoresis, Paper; Electrophoresis, Starch Gel; Evaluation S

1973
Urea and sickling.
    The New England journal of medicine, 1973, Oct-11, Volume: 289, Issue:15

    Topics: Anemia, Sickle Cell; Chemical Phenomena; Chemistry; Hemoglobin, Sickle; Humans; Urea

1973
Mechanism of urea activity in sickling.
    JAMA, 1973, Jul-16, Volume: 225, Issue:3

    Topics: Anemia, Sickle Cell; Erythrocytes; Hemoglobins; Humans; Urea

1973
Urea therapy in sickle cell disease: a report of 38 treated cases.
    East African medical journal, 1973, Volume: 50, Issue:12

    Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Anemia, Sickle Cell; Blood Cell Count; Blood

1973
Letter: Mechanism of urea activity in sickling.
    JAMA, 1973, Oct-29, Volume: 226, Issue:5

    Topics: Anemia, Sickle Cell; Humans; Urea

1973
The kidney in sickle cell disease V: Clinical manifestations.
    Ghana medical journal, 1973, Volume: 12, Issue:4

    Topics: Anemia, Sickle Cell; Bacteriuria; Enuresis; Erythrocyte Count; Glomerulonephritis; Hematuria; Humans

1973
Editorial: Sickle cell disease.
    The Yale journal of biology and medicine, 1974, Volume: 47, Issue:1

    Topics: Anemia, Sickle Cell; Cyanates; Humans; Urea

1974
Sickling, urea and cyanate.
    The New England journal of medicine, 1972, Feb-17, Volume: 286, Issue:7

    Topics: Adult; Anemia, Sickle Cell; Blood Urea Nitrogen; Child; Child, Preschool; Cyanates; Humans; Urea

1972
Oral urea therapy in sickle-cell anemia. A preliminary report.
    Annals of internal medicine, 1972, Volume: 76, Issue:5

    Topics: Administration, Oral; Anemia, Sickle Cell; Bilirubin; Blood Urea Nitrogen; Creatinine; Erythrocyte C

1972
Urea therapy in sickle cell disease.
    American family physician, 1972, Volume: 5, Issue:4

    Topics: Anemia, Sickle Cell; Cell Survival; Erythrocytes, Abnormal; Humans; Urea

1972
Effects of urea and cyanate on sickling in vitro.
    The New England journal of medicine, 1972, Jul-13, Volume: 287, Issue:2

    Topics: Anemia, Sickle Cell; Blood Urea Nitrogen; Blood Viscosity; Carbon Monoxide; Cyanates; Erythrocytes;

1972
[Therapeutic evaluation of oral urea in a case of sickle cell anemia].
    Revista medica de Chile, 1972, Volume: 100, Issue:4

    Topics: Administration, Oral; Adult; Anemia, Sickle Cell; Evaluation Studies as Topic; Female; Humans; Urea

1972
Urea, urease, cyanate, and the sickling of hemoglobin S.
    Clinical chemistry, 1972, Volume: 18, Issue:9

    Topics: Anaerobiosis; Anemia, Sickle Cell; Cyanates; Erythrocytes, Abnormal; Hemoglobins, Abnormal; Humans;

1972
Treatment of sickle-cell crises.
    The New England journal of medicine, 1972, Sep-21, Volume: 287, Issue:12

    Topics: Anemia, Sickle Cell; Diuresis; Humans; Injections, Intravenous; Urea

1972
Use of urea in sickle cell anemia.
    Postgraduate medicine, 1972, Volume: 52, Issue:3

    Topics: Anemia, Sickle Cell; Humans; Urea

1972
Sickle cell disease.
    Blood, 1972, Volume: 39, Issue:3

    Topics: Anemia, Sickle Cell; Carbamates; Cyanates; Epidemiologic Methods; Erythrocytes; Hemoglobins, Abnorma

1972
Sickle cell anemia. Conquest of a molecular disease.
    Journal of the National Medical Association, 1972, Volume: 64, Issue:1

    Topics: Anemia, Sickle Cell; Humans; Urea

1972
Chemical and biological aspects of the inhibition of red blood cell sickling by cyanate.
    Advances in experimental medicine and biology, 1972, Volume: 28

    Topics: Anemia, Sickle Cell; Carbamates; Cyanates; Erythrocytes, Abnormal; Hemoglobins, Abnormal; Humans; Ox

1972
Evaluation of oral urea in the management of sickle cell anemia.
    Advances in experimental medicine and biology, 1972, Volume: 28

    Topics: Administration, Oral; Anemia, Sickle Cell; Blood Platelets; Blood Urea Nitrogen; Erythrocytes; Hemat

1972
Urea and sickling.
    The New England journal of medicine, 1971, Jul-29, Volume: 285, Issue:5

    Topics: Administration, Oral; Adult; Anemia, Sickle Cell; Blood Urea Nitrogen; Child; Child, Preschool; Fema

1971
Urea therapy in sickle-cell anemia.
    The New England journal of medicine, 1971, Oct-28, Volume: 285, Issue:18

    Topics: Anemia, Sickle Cell; Cyanates; Heme; Hemolysis; Humans; Pain; Urea

1971
Intravenous urea treatment of the painful crisis of sickle-cell disease. A preliminary report.
    The New England journal of medicine, 1971, Oct-28, Volume: 285, Issue:18

    Topics: Adult; Anemia, Sickle Cell; Blood Urea Nitrogen; Diuresis; Hemoglobinopathies; Humans; Injections, I

1971
Effect of intravenous urea in invert sugar on heme catabolism in sickle-cell anemia.
    The New England journal of medicine, 1971, Oct-28, Volume: 285, Issue:18

    Topics: Anemia, Sickle Cell; Bilirubin; Blood Urea Nitrogen; Carbon Monoxide; Erythrocyte Count; Female; Fru

1971
Automated dithionite test for rapid, inexpensive detection of hemoglobin S and non-S sickling hemoglobinopathies.
    Clinical chemistry, 1971, Volume: 17, Issue:10

    Topics: Adult; Anemia, Sickle Cell; Autoanalysis; Chemical Phenomena; Chemistry; Child; Colorimetry; Crystal

1971
Dithionite tube test--a rapid, inexpensive technique for the detection of hemoglobin S and non-S sickling hemoglobin.
    Clinical chemistry, 1971, Volume: 17, Issue:10

    Topics: Adult; Anemia, Sickle Cell; Blood Preservation; Chemical Phenomena; Chemistry; Child; Crystallizatio

1971
Sickling reversed and blocked by urea in invert sugar.
    The American journal of pathology, 1971, Volume: 64, Issue:2

    Topics: Anemia, Sickle Cell; Erythrocyte Count; Erythrocytes, Abnormal; Fructose; Glucose; Hemoglobins, Abno

1971
Sickle cell crisis terminated by intravenous urea in sugar solutions--a preliminary report.
    The American journal of the medical sciences, 1971, Volume: 261, Issue:6

    Topics: Abdomen, Acute; Adolescent; Adult; Anemia, Sickle Cell; Blood Urea Nitrogen; Diuresis; Female; Gluco

1971
Oral urea and the prophylactic treatment of sickle cell disease--a preliminary report.
    The American journal of the medical sciences, 1971, Volume: 261, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Anemia, Sickle Cell; Blood Urea Nitrogen; Child; Female; Hu

1971
New strategy for sickle cell disease.
    JAMA, 1971, Dec-13, Volume: 218, Issue:11

    Topics: Adult; Anemia, Sickle Cell; Catheterization; Child; Humans; Infant; Injections, Intravenous; Urea

1971
The vasa recta and countercurrent multiplication.
    Acta medica Scandinavica. Supplementum, 1965, Volume: 434

    Topics: Anemia, Sickle Cell; Animals; Blood Flow Velocity; Blood Pressure; Humans; Kidney; Kidney Tubules; U

1965
Potassium cyanate as an inhibitor of the sickling of erythrocytes in vitro.
    Proceedings of the National Academy of Sciences of the United States of America, 1971, Volume: 68, Issue:6

    Topics: Anemia, Sickle Cell; Autoradiography; Carbamates; Carbon Isotopes; Cyanates; Erythrocytes; Erythrocy

1971
Arginase activity in erythrocytes of healthy and ill children.
    Clinica chimica acta; international journal of clinical chemistry, 1970, Volume: 28, Issue:3

    Topics: Adult; Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Sickle Cell; Arginase; Child; Child, Prescho

1970
Treatment of sickle crisis.
    The New England journal of medicine, 1971, 04-22, Volume: 284, Issue:15

    Topics: Anemia, Sickle Cell; Child; Humans; Injections, Intravenous; Urea

1971
Sickle cell disease: a molecular approach to pathogenesis, diagnosis and treatment.
    Michigan medicine, 1971, Volume: 70, Issue:10

    Topics: Administration, Oral; Anemia, Sickle Cell; Female; Humans; Pregnancy; Urea

1971
Urea treatment of sickle-cell crisis.
    The New England journal of medicine, 1971, Aug-12, Volume: 285, Issue:7

    Topics: Administration, Oral; Anemia, Sickle Cell; Humans; Injections, Intravenous; Urea

1971
Urea, cyanate and sickling.
    The New England journal of medicine, 1971, 09-16, Volume: 285, Issue:12

    Topics: Anemia, Sickle Cell; Cyanates; Hemoglobins, Abnormal; Humans; Urea

1971
Urea for sickle-cell crises.
    The New England journal of medicine, 1971, Jun-17, Volume: 284, Issue:24

    Topics: Anemia, Sickle Cell; Blood Urea Nitrogen; Humans; Urea

1971
Effect of dietary protein on the renal concentrating process. In sickle cell anemia.
    American journal of diseases of children (1960), 1968, Volume: 115, Issue:2

    Topics: Adolescent; Anemia, Sickle Cell; Child; Creatine; Dietary Proteins; Female; Humans; Kidney; Kidney F

1968
Problems in management of subarachnoid hemorrhage in sickle cell anemia.
    Journal of neurosurgery, 1965, Volume: 23, Issue:5

    Topics: Adult; Anemia, Sickle Cell; Black or African American; Cerebral Angiography; Contrast Media; Erythro

1965