urea has been researched along with Cancer of Liver in 125 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study is validated the prophylactic efficacy of urea-based creams on sorafenib-induced hand-foot skin reaction in patients with advanced hepatocellular carcinoma." | 9.51 | Validation of the prophylactic efficacy of urea-based creams on sorafenib-induced hand-foot skin reaction in patients with advanced hepatocellular carcinoma: A randomised experiment study. ( Hu, SH; Lien, RY; Lu, LC; Lu, SF; Tung, HH; Wu, SL, 2022) |
| "Hand-foot skin reaction (HFSR) is the most common adverse event during sorafenib treatment in patients with hepatocellular carcinoma (HCC)." | 9.34 | Effect of urea cream on sorafenib-associated hand-foot skin reaction in patients with hepatocellular carcinoma: A multicenter, randomised, double-blind controlled study. ( Cho, SB; Hong, YM; Hwang, SY; Jang, BK; Jang, ES; Jang, JY; Jung, YK; Kim, DY; Kim, HJ; Kim, JH; Kim, MY; Lee, HW; Lee, JH; Lee, YS; Seo, YS; Yim, HJ; Yoon, KT, 2020) |
| "To assess whether urea-based cream (UBC) has prophylactic benefits on sorafenib-induced hand-foot skin reaction (HFSR) in patients with advanced hepatocellular carcinoma (HCC)." | 9.20 | Randomized controlled trial of the prophylactic effect of urea-based cream on sorafenib-associated hand-foot skin reactions in patients with advanced hepatocellular carcinoma. ( Bai, Y; Guo, X; Kang, H; Lu, L; Lu, M; Qu, Z; Ren, Z; Shi, L; Song, T; Wang, H; Wang, X; Yang, W; Yang, Y; Ye, SL; Zhou, W; Zhu, K, 2015) |
| " RESULTS In the mouse model of NAFLD, RKI-1447 reduced insulin resistance and the levels of alanine aminotransferase (ALT), aspartate transaminase (AST), total cholesterol, triglyceride, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), malondialdehyde (MDA), and superoxide dismutase (SOD)." | 7.96 | The Effects of RKI-1447 in a Mouse Model of Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet and in HepG2 Human Hepatocellular Carcinoma Cells Treated with Oleic Acid. ( Jiang, W; Wang, J, 2020) |
| "In our effort to develop potent and effective agents with anti-proliferative activity towards HepG2 hepatocellular carcinoma cells with potential inhibitory activity against VEGFR-2, a novel series of 1-(4-((2-oxoindolin-3-ylidene)amino)phenyl)-3-arylureas was designed and synthesized." | 7.81 | Indoline ureas as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro biological evaluation and molecular docking. ( Abdel-Aziz, HA; Abou El Ella, DA; Abou-Seri, SM; Ali, MM; Aly, MH; Eldehna, WM; Fares, M; Ibrahim, HS; Zada, S, 2015) |
| "The aim of this study is validated the prophylactic efficacy of urea-based creams on sorafenib-induced hand-foot skin reaction in patients with advanced hepatocellular carcinoma." | 5.51 | Validation of the prophylactic efficacy of urea-based creams on sorafenib-induced hand-foot skin reaction in patients with advanced hepatocellular carcinoma: A randomised experiment study. ( Hu, SH; Lien, RY; Lu, LC; Lu, SF; Tung, HH; Wu, SL, 2022) |
| "In this report, we show that human hepatocellular carcinoma (HCC) cells do not express CPS1, whereas cultured human primary hepatocytes express abundant levels." | 5.37 | DNA methylation suppresses expression of the urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) in human hepatocellular carcinoma. ( Dong, H; Liu, C; Liu, H; Robertson, K, 2011) |
| "Hand-foot skin reaction (HFSR) is the most common adverse event during sorafenib treatment in patients with hepatocellular carcinoma (HCC)." | 5.34 | Effect of urea cream on sorafenib-associated hand-foot skin reaction in patients with hepatocellular carcinoma: A multicenter, randomised, double-blind controlled study. ( Cho, SB; Hong, YM; Hwang, SY; Jang, BK; Jang, ES; Jang, JY; Jung, YK; Kim, DY; Kim, HJ; Kim, JH; Kim, MY; Lee, HW; Lee, JH; Lee, YS; Seo, YS; Yim, HJ; Yoon, KT, 2020) |
| "To assess whether urea-based cream (UBC) has prophylactic benefits on sorafenib-induced hand-foot skin reaction (HFSR) in patients with advanced hepatocellular carcinoma (HCC)." | 5.20 | Randomized controlled trial of the prophylactic effect of urea-based cream on sorafenib-associated hand-foot skin reactions in patients with advanced hepatocellular carcinoma. ( Bai, Y; Guo, X; Kang, H; Lu, L; Lu, M; Qu, Z; Ren, Z; Shi, L; Song, T; Wang, H; Wang, X; Yang, W; Yang, Y; Ye, SL; Zhou, W; Zhu, K, 2015) |
| "Irinotecan (Campto, Rhône-Poulenc Rorer) is probably the most studied drug used as second-line treatment for colorectal cancer." | 5.09 | Colorectal cancer: dilemmas regarding patient selection and toxicity prediction. ( Jelic, S; Nikolic-Tomasevic, Z; Popov, I; Radosavljevic, D, 2000) |
| " AQP3 is involved in the diarrhea and inflammatory bowel disease; AQP5 is relevant to gastric carcinoma cell proliferation and migration; AQP9 plays considerable role in glycerol metabolism , urea transport and hepatocellular carcinoma." | 4.95 | Aquaporins in Digestive System. ( Mei, Z; Ran, J; Yang, B; Zhu, S, 2017) |
| "We aimed to determine the association between blood urea level and incident cirrhosis, hepatic decompensation, and hepatocellular carcinoma in chronic liver disease (CLD) patients." | 4.12 | U-shaped relationship between urea level and hepatic decompensation in chronic liver diseases. ( Chan, HL; Hui, VW; Lai, JC; Lin, H; Liu, K; Tse, YK; Wong, GL; Wong, VW; Yip, TC; Zhang, X, 2022) |
| " RESULTS In the mouse model of NAFLD, RKI-1447 reduced insulin resistance and the levels of alanine aminotransferase (ALT), aspartate transaminase (AST), total cholesterol, triglyceride, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), malondialdehyde (MDA), and superoxide dismutase (SOD)." | 3.96 | The Effects of RKI-1447 in a Mouse Model of Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet and in HepG2 Human Hepatocellular Carcinoma Cells Treated with Oleic Acid. ( Jiang, W; Wang, J, 2020) |
| " Among these analogues, 3y exhibited a better cytotoxic effect on human hepatocellular carcinoma (HCC) Hep 3B cells and displayed less cytotoxicity on normal human umbilical vein endothelial cells, compared with Sorafenib, a targeted therapy for advanced HCC." | 3.85 | Using gene expression database to uncover biology functions of 1,4-disubstituted 1,2,3-triazole analogues synthesized via a copper (I)-catalyzed reaction. ( Huang, CF; Liu, HS; Ramesh, C; Su, CL; Tseng, CL; Yao, CF, 2017) |
| "In our effort to develop potent and effective agents with anti-proliferative activity towards HepG2 hepatocellular carcinoma cells with potential inhibitory activity against VEGFR-2, a novel series of 1-(4-((2-oxoindolin-3-ylidene)amino)phenyl)-3-arylureas was designed and synthesized." | 3.81 | Indoline ureas as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro biological evaluation and molecular docking. ( Abdel-Aziz, HA; Abou El Ella, DA; Abou-Seri, SM; Ali, MM; Aly, MH; Eldehna, WM; Fares, M; Ibrahim, HS; Zada, S, 2015) |
| " Here, we report the effect of an APN inhibitor 4cc in enhancing sensitivity of hepatocellular carcinoma (HCC) cell lines and xenograft model in response to 5-fluorouracil (5-FU) in vivo and in vitro." | 3.81 | Aminopeptidase N inhibitor 4cc synergizes antitumor effects of 5-fluorouracil on human liver cancer cells through ROS-dependent CD13 inhibition. ( Dai, G; Duan, Y; Shi, LH; Sun, ZP; Wang, XJ; Xu, WF; Zhang, J; Zhang, XR, 2015) |
| "The rates of urea synthesis in rat liver and in a series of rat liver neoplasms with widely different growth rates and degree of differentiation were investigated using tissue slices incubated in a Krebs-Ringer bicarbonate buffer." | 3.65 | Urea synthesis in Novikoff and Morris hepatomas. ( Lawson, D; Morris, HP; Paik, WK; Weinhouse, S, 1977) |
| " Although some evidence of damage to the gastrinsecreting cells was obtained, the fasting plasma gastrin was not significantly altered and the patient died from a perforated duodenal ulcer." | 3.65 | Further studies on streptozotocin therapy for a multiple-hormone-producing islet cell carcinoma. ( Cassar, J; Coulson, R; Edwards, JC; Ganguli, PC; Murray-Lyon, IM; Taylor, KW; Williams, R, 1971) |
| "The purpose of this Functional Imaging Liver Cancer (FLIC) trial is to assess the ability of 18F-DCFPyL-PET/CT to detect sites of HCC." | 3.11 | Functional Imaging of Liver Cancer (FLIC): Study protocol of a phase 2 trial of 18F-DCFPyL PET/CT imaging for patients with hepatocellular carcinoma. ( Choyke, PL; Chung, JY; Escorcia, FE; Hernandez, J; Jakhete, N; Jones, J; Kassin, M; Lindenberg, L; Maass-Moreno, R; Mena, E; Molitoris, JK; Monge, C; Rabiee, A; Saboury, B; Salerno, KE; Shih, J; Turkbey, B; Unger, KR; Wood, B, 2022) |
| " The results of cytotoxicity and flow cytometry data showed that the compounds had a moderate to strong effect against MCF-7 and HepG2 cells and were less toxic to HEK293 cells." | 1.42 | Novel all trans-retinoic Acid derivatives: cytotoxicity, inhibition of cell cycle progression and induction of apoptosis in human cancer cell lines. ( Al-Khedhairy, AA; Al-Oqail, MM; Al-Sheddi, ES; Farshori, NN; Musarrat, J; Saquib, Q; Siddiqui, MA, 2015) |
| "HepG2 is a human hepatoma that is most commonly used in drug metabolism and hepatotoxicity studies." | 1.42 | Culture and Functional Characterization of Human Hepatoma HepG2 Cells. ( Donato, MT; Gómez-Lechón, MJ; Tolosa, L, 2015) |
| "In this report, we show that human hepatocellular carcinoma (HCC) cells do not express CPS1, whereas cultured human primary hepatocytes express abundant levels." | 1.37 | DNA methylation suppresses expression of the urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) in human hepatocellular carcinoma. ( Dong, H; Liu, C; Liu, H; Robertson, K, 2011) |
| "Percutaneous microwave ablation of primary and metastatic liver tumor is no adverse influence on renal function for patients with renal dysfunction in this preliminary series, which can be a minimally invasive alternative therapy." | 1.37 | Is percutaneous microwave ablation of liver tumor safe for patients with renal dysfunction. ( Dong, B; Liang, P; Liu, C; Ren, H; Wang, Y; Yu, X; Zhou, P, 2011) |
| "01), at least compatible to the inhibition by vincristine (43% inhibition), indicating good bioavailability of the compound in the circulation." | 1.32 | Inhibition of microtubule polymerization by 3-bromopropionylamino benzoylurea (JIMB01), a new cancericidal tubulin ligand. ( Bekesi, G; Holland, JF; Hu, QY; Jiang, JD; Li, JN; Lin, YH; Song, DQ; Yin, L, 2003) |
| "In horses with hepatic necrosis, lipidosis, neoplasia and cirrhosis, progression of the disease was studied by serial measurements of total serum bile acid concentrations and of plasma glutamate dehydrogenase (GD) and gamma glutamyl transferase (gamma GT) and by liver biopsy." | 1.29 | Clinical and pathological studies in horses with hepatic disease. ( West, HJ, 1996) |
| "Orotic acid feeding was also associated with the tendency for development of larger mammary tumors induced by chemical carcinogens in rats and with development of urinary bladder calculi containing high concentrations of orotic acid in mice." | 1.28 | Nitrogen-stimulated orotic acid synthesis and nucleotide imbalance. ( Visek, WJ, 1992) |
| "In fact, the hepatomas showed the greatest changes in response to diet." | 1.26 | Regulation of urea cycle enzymes in transplantable hepatomas and in the livers of tumor-bearing rats and humans. ( Balinsky, JB; Brebnor, LD; Grimm, J, 1981) |
| "Urea therapy is a simple, cheap, and safe method of treating advanced stages of cancer, where very little can be done by the accepted lines of treatment such as surgery or radiotherapy." | 1.26 | Urea in the management of advanced malignancies (preliminary report). ( Anasuya, SR; Gandhi, GM; Kawathekar, P; Krishnamurthy, KR, 1977) |
| "Faster growing hepatomas also have greater quantities of sulfhydryls and disulfides." | 1.25 | Sulfhydryl group quantitation of hepatoma and liver microsomal fractions. ( Hochberg, AA; Morris, HP; Stratman, FW; Zahlten, RN, 1975) |
| "Ferritin purified from hepatoma tissue migrated slightly faster than normal human liver ferritin in polyacrylamide gel electrophoresis." | 1.25 | Characterization and subunit analysis of ferritin isolated from normal and malignant human liver. ( Alpert, E, 1975) |
| "Acceptable cases of parathyroid carcinoma are rare, but carcinoma is an important cause of recurrent hyperparathyroidism even months or years after removal of an ;adenoma'." | 1.25 | Recurrent hyperparathyroidism due to parathyroid carcinoma. ( Ellis, HA; Floyd, M; Herbert, FK, 1971) |
| "In the hepatomas, evidence was obtained for the preexistence of considerable amounts of the smaller, RNase-containing subunits in the cell." | 1.24 | Studies on the function of intracellular ribonucleases. V. Ribonuclease activity in ribosomes and polysomes prepared from rat liver and hepatomas. ( Roth, JS; Utsunomiya, T, 1966) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 68 (54.40) | 18.7374 |
| 1990's | 6 (4.80) | 18.2507 |
| 2000's | 13 (10.40) | 29.6817 |
| 2010's | 22 (17.60) | 24.3611 |
| 2020's | 16 (12.80) | 2.80 |
| Authors | Studies |
|---|---|
| Meng, Y | 2 |
| Li, LL | 1 |
| Wang, H | 5 |
| Zhao, X | 1 |
| Lin, H | 1 |
| Wong, GL | 1 |
| Zhang, X | 5 |
| Yip, TC | 1 |
| Liu, K | 1 |
| Tse, YK | 1 |
| Hui, VW | 1 |
| Lai, JC | 1 |
| Chan, HL | 1 |
| Wong, VW | 1 |
| Li, J | 9 |
| Shi, C | 1 |
| Shi, J | 1 |
| Song, J | 4 |
| Wang, N | 1 |
| Lien, RY | 1 |
| Tung, HH | 1 |
| Wu, SL | 1 |
| Hu, SH | 1 |
| Lu, LC | 1 |
| Lu, SF | 1 |
| Sugiura, S | 1 |
| Satoh, T | 1 |
| Shin, K | 1 |
| Onuki-Nagasaki, R | 1 |
| Kanamori, T | 1 |
| Dai, W | 1 |
| Shen, J | 4 |
| Yan, J | 1 |
| Bott, AJ | 1 |
| Maimouni, S | 1 |
| Daguplo, HQ | 1 |
| Wang, Y | 5 |
| Khayati, K | 1 |
| Guo, JY | 1 |
| Zhang, L | 3 |
| Valvezan, A | 1 |
| Ding, WX | 1 |
| Chen, X | 3 |
| Su, X | 2 |
| Gao, S | 1 |
| Zong, WX | 1 |
| Mena, E | 1 |
| Shih, J | 1 |
| Chung, JY | 1 |
| Jones, J | 1 |
| Rabiee, A | 1 |
| Monge, C | 1 |
| Turkbey, B | 1 |
| Lindenberg, L | 1 |
| Salerno, KE | 1 |
| Kassin, M | 1 |
| Wood, B | 1 |
| Hernandez, J | 1 |
| Maass-Moreno, R | 1 |
| Saboury, B | 1 |
| Jakhete, N | 1 |
| Molitoris, JK | 1 |
| Unger, KR | 1 |
| Choyke, PL | 1 |
| Escorcia, FE | 1 |
| Zhang, S | 6 |
| Hu, Y | 3 |
| Wu, Z | 3 |
| Zhou, X | 5 |
| Wu, T | 4 |
| Li, P | 4 |
| Lian, Q | 3 |
| Xu, S | 3 |
| Gu, J | 3 |
| Chen, L | 6 |
| Wu, G | 4 |
| Zhang, T | 5 |
| Tang, J | 3 |
| Xue, J | 3 |
| Ivanova, ON | 1 |
| Krasnov, GS | 1 |
| Snezhkina, AV | 1 |
| Kudryavtseva, AV | 1 |
| Fedorov, VS | 1 |
| Zakirova, NF | 1 |
| Golikov, MV | 1 |
| Kochetkov, SN | 1 |
| Bartosch, B | 1 |
| Valuev-Elliston, VT | 1 |
| Ivanov, AV | 1 |
| Wang, J | 5 |
| Jiang, W | 1 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 5 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
| Chavan, S | 1 |
| Shi, X | 1 |
| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
| Veziroglu, E | 1 |
| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
| Kache, S | 1 |
| Mainwaring, RD | 1 |
| Ma, M | 1 |
| Maeda, K | 1 |
| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
| Iwasa, Y | 3 |
| Ling, J | 2 |
| Voccio, JP | 2 |
| Kim, Y | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
| Palomeque, E | 1 |
| Saud, N | 1 |
| Hoplock, LB | 1 |
| Lobchuk, MM | 1 |
| Lemoine, J | 1 |
| Li, X | 10 |
| Henson, MA | 1 |
| Unsihuay, D | 1 |
| Qiu, J | 1 |
| Swaroop, S | 1 |
| Nagornov, KO | 1 |
| Kozhinov, AN | 1 |
| Tsybin, YO | 1 |
| Kuang, S | 1 |
| Laskin, J | 1 |
| Zin, NNINM | 1 |
| Mohamad, MN | 1 |
| Roslan, K | 1 |
| Abdul Wafi, S | 1 |
| Abdul Moin, NI | 1 |
| Alias, A | 1 |
| Zakaria, Y | 1 |
| Abu-Bakar, N | 1 |
| Naveed, A | 1 |
| Jilani, K | 1 |
| Siddique, AB | 1 |
| Akbar, M | 1 |
| Riaz, M | 1 |
| Mushtaq, Z | 1 |
| Sikandar, M | 1 |
| Ilyas, S | 1 |
| Bibi, I | 1 |
| Asghar, A | 1 |
| Rasool, G | 1 |
| Irfan, M | 1 |
| Li, XY | 1 |
| Zhao, S | 1 |
| Fan, XH | 1 |
| Chen, KP | 1 |
| Hua, W | 1 |
| Liu, ZM | 1 |
| Xue, XD | 1 |
| Zhou, B | 1 |
| Xing, YL | 1 |
| Chen, MA | 1 |
| Sun, Y | 1 |
| Neradilek, MB | 1 |
| Wu, XT | 1 |
| Zhang, D | 2 |
| Huang, W | 1 |
| Cui, Y | 1 |
| Yang, QQ | 1 |
| Li, HW | 1 |
| Zhao, XQ | 1 |
| Hossein Rashidi, B | 1 |
| Tarafdari, A | 1 |
| Ghazimirsaeed, ST | 1 |
| Shahrokh Tehraninezhad, E | 1 |
| Keikha, F | 1 |
| Eslami, B | 1 |
| Ghazimirsaeed, SM | 1 |
| Jafarabadi, M | 1 |
| Silvani, Y | 1 |
| Lovita, AND | 1 |
| Maharani, A | 1 |
| Wiyasa, IWA | 1 |
| Sujuti, H | 1 |
| Ratnawati, R | 1 |
| Raras, TYM | 1 |
| Lemin, AS | 1 |
| Rahman, MM | 1 |
| Pangarah, CA | 1 |
| Kiyu, A | 1 |
| Zeng, C | 2 |
| Du, H | 1 |
| Lin, D | 1 |
| Jalan, D | 1 |
| Rubagumya, F | 1 |
| Hopman, WM | 1 |
| Vanderpuye, V | 1 |
| Lopes, G | 1 |
| Seruga, B | 1 |
| Booth, CM | 1 |
| Berry, S | 1 |
| Hammad, N | 1 |
| Sajo, EA | 1 |
| Okunade, KS | 1 |
| Olorunfemi, G | 1 |
| Rabiu, KA | 1 |
| Anorlu, RI | 1 |
| Xu, C | 2 |
| Xiang, Y | 1 |
| Xu, X | 1 |
| Zhou, L | 3 |
| Dong, X | 1 |
| Tang, S | 1 |
| Gao, XC | 1 |
| Wei, CH | 1 |
| Zhang, RG | 1 |
| Cai, Q | 1 |
| He, Y | 1 |
| Tong, F | 1 |
| Dong, JH | 1 |
| Dong, XR | 1 |
| Tang, X | 1 |
| Tao, F | 1 |
| Xiang, W | 1 |
| Zhao, Y | 2 |
| Jin, L | 1 |
| Tao, H | 1 |
| Lei, Y | 1 |
| Gan, H | 1 |
| Huang, Y | 1 |
| Chen, Y | 3 |
| Shan, A | 1 |
| Zhao, H | 2 |
| Wu, M | 2 |
| Ma, Q | 1 |
| Zhang, E | 1 |
| Zhang, J | 5 |
| Li, Y | 5 |
| Xue, F | 1 |
| Deng, L | 1 |
| Liu, L | 2 |
| Yan, Z | 2 |
| Meng, J | 1 |
| Chen, G | 3 |
| Anastassiadou, M | 1 |
| Bernasconi, G | 1 |
| Brancato, A | 1 |
| Carrasco Cabrera, L | 1 |
| Greco, L | 1 |
| Jarrah, S | 1 |
| Kazocina, A | 1 |
| Leuschner, R | 1 |
| Magrans, JO | 1 |
| Miron, I | 1 |
| Nave, S | 1 |
| Pedersen, R | 1 |
| Reich, H | 1 |
| Rojas, A | 1 |
| Sacchi, A | 1 |
| Santos, M | 1 |
| Theobald, A | 1 |
| Vagenende, B | 1 |
| Verani, A | 1 |
| Du, L | 1 |
| Liu, X | 1 |
| Ren, Y | 1 |
| Jiao, Q | 1 |
| Meng, P | 1 |
| Wang, F | 2 |
| Wang, YS | 1 |
| Wang, C | 3 |
| Wang, W | 1 |
| Wang, S | 2 |
| Hou, J | 1 |
| Zhang, A | 2 |
| Lv, B | 1 |
| Gao, C | 1 |
| Pang, D | 1 |
| Lu, K | 1 |
| Ahmad, NH | 1 |
| Wang, L | 1 |
| Zhu, J | 2 |
| Zhuang, T | 1 |
| Tu, J | 1 |
| Zhao, Z | 1 |
| Qu, Y | 1 |
| Yao, H | 1 |
| Wang, X | 6 |
| Lee, DF | 1 |
| Wen, L | 1 |
| Huang, G | 2 |
| Xie, X | 1 |
| Zhao, Q | 1 |
| Hu, W | 2 |
| Zhang, Y | 4 |
| Wu, X | 1 |
| Lu, J | 2 |
| Li, M | 2 |
| Li, W | 2 |
| Wu, W | 1 |
| Du, F | 1 |
| Ji, H | 1 |
| Yang, X | 2 |
| Xu, Z | 1 |
| Wan, L | 1 |
| Wen, Q | 1 |
| Cho, CH | 1 |
| Zou, C | 1 |
| Xiao, Z | 1 |
| Liao, J | 1 |
| Bi, Z | 1 |
| Su, Q | 1 |
| Huang, H | 1 |
| Wei, Y | 2 |
| Gao, Y | 2 |
| Na, KJ | 1 |
| Choi, H | 1 |
| Oh, HR | 1 |
| Kim, YH | 1 |
| Lee, SB | 1 |
| Jung, YJ | 1 |
| Koh, J | 1 |
| Park, S | 1 |
| Lee, HJ | 1 |
| Jeon, YK | 1 |
| Chung, DH | 1 |
| Paeng, JC | 1 |
| Park, IK | 1 |
| Kang, CH | 1 |
| Cheon, GJ | 1 |
| Kang, KW | 1 |
| Lee, DS | 1 |
| Kim, YT | 1 |
| Pajuelo-Lozano, N | 1 |
| Alcalá, S | 1 |
| Sainz, B | 1 |
| Perona, R | 1 |
| Sanchez-Perez, I | 1 |
| Logotheti, S | 1 |
| Marquardt, S | 1 |
| Gupta, SK | 1 |
| Richter, C | 1 |
| Edelhäuser, BAH | 1 |
| Engelmann, D | 1 |
| Brenmoehl, J | 1 |
| Söhnchen, C | 1 |
| Murr, N | 1 |
| Alpers, M | 1 |
| Singh, KP | 1 |
| Wolkenhauer, O | 1 |
| Heckl, D | 1 |
| Spitschak, A | 1 |
| Pützer, BM | 1 |
| Liao, Y | 1 |
| Cheng, J | 1 |
| Kong, X | 1 |
| Li, S | 1 |
| Zhang, M | 4 |
| Zhang, H | 1 |
| Yang, T | 2 |
| Dong, Y | 1 |
| Xu, Y | 1 |
| Yuan, Z | 1 |
| Cao, J | 1 |
| Zheng, Y | 1 |
| Luo, Z | 1 |
| Mei, Z | 2 |
| Yao, Y | 1 |
| Liu, Z | 2 |
| Liang, C | 1 |
| Yang, H | 2 |
| Song, Y | 1 |
| Yu, K | 1 |
| Zhu, C | 1 |
| Huang, Z | 1 |
| Qian, J | 1 |
| Ge, J | 1 |
| Hu, J | 2 |
| Liu, Y | 4 |
| Mi, Y | 1 |
| Kong, H | 1 |
| Xi, D | 1 |
| Yan, W | 1 |
| Luo, X | 1 |
| Ning, Q | 1 |
| Chang, X | 2 |
| Wang, Q | 2 |
| Rathore, MG | 1 |
| Reddy, K | 1 |
| Chen, H | 2 |
| Shin, SH | 1 |
| Ma, WY | 1 |
| Bode, AM | 1 |
| Dong, Z | 1 |
| Mu, W | 1 |
| Liu, C | 5 |
| Gao, F | 1 |
| Qi, Y | 1 |
| Lu, H | 1 |
| Cai, X | 1 |
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| Lee, JH | 2 |
| Lee, HW | 1 |
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| Jang, JY | 1 |
| Hwang, SY | 1 |
| Lee, YB | 1 |
| Cho, EJ | 1 |
| Yu, SJ | 1 |
| Kim, YJ | 1 |
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| Negri, FV | 1 |
| Porta, C | 1 |
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| Gómez-Lechón, MJ | 2 |
| Zhang, B | 1 |
| Dong, S | 1 |
| Cen, X | 1 |
| Sun, ZP | 1 |
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| Zhang, XR | 1 |
| Duan, Y | 1 |
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| Dai, G | 1 |
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| Zhu, S | 1 |
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| Yang, B | 1 |
| Reilly, LM | 1 |
| Gerami, P | 1 |
| Guitart, J | 1 |
| Tsai, WB | 1 |
| Lin, JH | 1 |
| London, R | 1 |
| Schulz, FM | 1 |
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| Delriviere, L | 1 |
| Chandraratana, H | 1 |
| Hardy, K | 1 |
| Zheng, S | 1 |
| Olynyk, JK | 1 |
| Yeoh, G | 1 |
| Harm, S | 1 |
| Stroble, K | 1 |
| Hartmann, J | 1 |
| Falkenhagen, D | 1 |
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| d'Agostino, R | 1 |
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| Dong, H | 1 |
| Robertson, K | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Re-validating Prophylactic Efficacy of Urea-based Cream on Sorafenib-induced Hand-foot Skin Reaction in Patients With Advanced Hepatocellular Carcinoma[NCT04568330] | 129 participants (Actual) | Interventional | 2014-03-21 | Completed | |||
| 18F-DCFPyL PET/CT in Hepatocellular Carcinoma[NCT05009979] | Phase 2 | 50 participants (Anticipated) | Interventional | 2023-01-18 | Recruiting | ||
| The Effect of Urea Cream on Sorafenib-associated Hand-Foot Skin Reaction in Patients With Korean Hepatocellular Carcinoma Patients: Multicenter, Prospective Randomized Double-Blind Controlled Study[NCT03212625] | Phase 4 | 288 participants (Actual) | Interventional | 2016-01-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for urea and Cancer of Liver
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Aquaporins in Digestive System.
Topics: Animals; Aquaporin 1; Biological Transport; Carcinoma, Hepatocellular; Cell Movement; Cell Prolifera | 2017 |
Use of newborn and infant animals in carcinogenicity testing.
Topics: Age Factors; Animals; Animals, Newborn; Anthracenes; Carcinogens; Carcinoma, Hepatocellular; Hydroca | 1968 |
[Abnormality in ontogeney and phylogeney in cancer cells with special reference to nitrogen metabolism].
Topics: Animals; Biological Evolution; Carcinoma, Hepatocellular; DNA, Neoplasm; Glutaminase; Isoenzymes; Ki | 1971 |
Two carbamyl phosphate synthetases of mammals: specific roles in control of pyrimidine and urea biosynthesis.
Topics: Adenosine Triphosphate; Animals; Arginine; Aspartic Acid; Carbamates; Carbon Isotopes; Carcinoma, He | 1972 |
[Enzymological study of amino acid nutrition. Physiological roles of serine dehydratase and cystathionine synthetase].
Topics: Amino Acids; Animals; Blood Glucose; Carbon Isotopes; Diabetes Mellitus, Experimental; Diet; Electro | 1971 |
7 trials available for urea and Cancer of Liver
| Article | Year |
|---|---|
Validation of the prophylactic efficacy of urea-based creams on sorafenib-induced hand-foot skin reaction in patients with advanced hepatocellular carcinoma: A randomised experiment study.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Hand-Foot Syndrome; Humans; Liver Neoplasms; Niaci | 2022 |
Functional Imaging of Liver Cancer (FLIC): Study protocol of a phase 2 trial of 18F-DCFPyL PET/CT imaging for patients with hepatocellular carcinoma.
Topics: Carcinoma, Hepatocellular; Clinical Trials, Phase II as Topic; Fluorodeoxyglucose F18; Humans; Liver | 2022 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Effect of urea cream on sorafenib-associated hand-foot skin reaction in patients with hepatocellular carcinoma: A multicenter, randomised, double-blind controlled study.
Topics: Aged; Antineoplastic Agents; Carcinoma, Hepatocellular; Double-Blind Method; Female; Hand-Foot Syndr | 2020 |
Randomized controlled trial of the prophylactic effect of urea-based cream on sorafenib-associated hand-foot skin reactions in patients with advanced hepatocellular carcinoma.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Hepatocel | 2015 |
Randomized controlled trial of the prophylactic effect of urea-based cream on sorafenib-associated hand-foot skin reactions in patients with advanced hepatocellular carcinoma.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Hepatocel | 2015 |
Randomized controlled trial of the prophylactic effect of urea-based cream on sorafenib-associated hand-foot skin reactions in patients with advanced hepatocellular carcinoma.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Hepatocel | 2015 |
Randomized controlled trial of the prophylactic effect of urea-based cream on sorafenib-associated hand-foot skin reactions in patients with advanced hepatocellular carcinoma.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Hepatocel | 2015 |
Urea--treatment of liver metastases.
Topics: Adult; Aged; Female; Humans; Liver Neoplasms; Male; Middle Aged; Urea | 1981 |
Colorectal cancer: dilemmas regarding patient selection and toxicity prediction.
Topics: Adult; Antineoplastic Agents, Phytogenic; Blood Proteins; Camptothecin; Colorectal Neoplasms; Creati | 2000 |
113 other studies available for urea and Cancer of Liver
| Article | Year |
|---|---|
[Ripretinib in the treatment of advanced gastrointestinal stromal tumor with metastases in liver, lung and bone: a case report].
Topics: Antineoplastic Agents; Gastrointestinal Stromal Tumors; Humans; Liver; Liver Neoplasms; Lung; Naphth | 2021 |
U-shaped relationship between urea level and hepatic decompensation in chronic liver diseases.
Topics: Carcinoma, Hepatocellular; Elasticity Imaging Techniques; Humans; Liver Cirrhosis; Liver Failure; Li | 2022 |
Determination of risk factors for fever after transarterial chemoembolization with drug-eluting beads for hepatocellular carcinoma.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; China | 2021 |
Perfusion culture of multi-layered HepG2 hepatocellular carcinoma cells in a pressure-driven microphysiological system.
Topics: Albumins; Carcinoma, Hepatocellular; Cell Culture Techniques; Hep G2 Cells; Hepatocytes; Humans; Liv | 2022 |
Glutamine synthetase limits β-catenin-mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1.
Topics: Ammonia; Animals; beta Catenin; Glutamate-Ammonia Ligase; Glutamine; Homeostasis; Liver; Liver Neopl | 2022 |
Deficiency of Carbamoyl Phosphate Synthetase 1 Engenders Radioresistance in Hepatocellular Carcinoma via Deubiquitinating c-Myc.
Topics: Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase I Deficiency Disease; Carbamyl | 2023 |
Deficiency of Carbamoyl Phosphate Synthetase 1 Engenders Radioresistance in Hepatocellular Carcinoma via Deubiquitinating c-Myc.
Topics: Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase I Deficiency Disease; Carbamyl | 2023 |
Deficiency of Carbamoyl Phosphate Synthetase 1 Engenders Radioresistance in Hepatocellular Carcinoma via Deubiquitinating c-Myc.
Topics: Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase I Deficiency Disease; Carbamyl | 2023 |
Deficiency of Carbamoyl Phosphate Synthetase 1 Engenders Radioresistance in Hepatocellular Carcinoma via Deubiquitinating c-Myc.
Topics: Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase I Deficiency Disease; Carbamyl | 2023 |
Deficiency of Carbamoyl Phosphate Synthetase 1 Engenders Radioresistance in Hepatocellular Carcinoma via Deubiquitinating c-Myc.
Topics: Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase I Deficiency Disease; Carbamyl | 2023 |
Deficiency of Carbamoyl Phosphate Synthetase 1 Engenders Radioresistance in Hepatocellular Carcinoma via Deubiquitinating c-Myc.
Topics: Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase I Deficiency Disease; Carbamyl | 2023 |
Deficiency of Carbamoyl Phosphate Synthetase 1 Engenders Radioresistance in Hepatocellular Carcinoma via Deubiquitinating c-Myc.
Topics: Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase I Deficiency Disease; Carbamyl | 2023 |
Deficiency of Carbamoyl Phosphate Synthetase 1 Engenders Radioresistance in Hepatocellular Carcinoma via Deubiquitinating c-Myc.
Topics: Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase I Deficiency Disease; Carbamyl | 2023 |
Deficiency of Carbamoyl Phosphate Synthetase 1 Engenders Radioresistance in Hepatocellular Carcinoma via Deubiquitinating c-Myc.
Topics: Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase I Deficiency Disease; Carbamyl | 2023 |
Transcriptome Analysis of Redox Systems and Polyamine Metabolic Pathway in Hepatoma and Non-Tumor Hepatocyte-like Cells.
Topics: Carcinoma, Hepatocellular; Gene Expression Profiling; Hepatocytes; Humans; Liver Neoplasms; Metaboli | 2023 |
The Effects of RKI-1447 in a Mouse Model of Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet and in HepG2 Human Hepatocellular Carcinoma Cells Treated with Oleic Acid.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Cholesterol; | 2020 |
CKD-5, a novel pan-histone deacetylase inhibitor, synergistically enhances the efficacy of sorafenib for hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line, Tumor; C | 2020 |
Screening of anticancer, hepatoprotective and nephroprotective effects of ethanol extract of Elephantopus scaber L.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alanine Transaminase; Animals; Anticarcinogenic Agents; Aspartate | 2020 |
Feasibility of Phosphoproteomics on Leftover Samples After RNA Extraction With Guanidinium Thiocyanate.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Chloroform; DNA Damage; Feasibility Studies; Guanidin | 2021 |
Induction of Divergent Cell Death Pathways by Urea and Carbohydrazide Derivatives.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Endoplasmic Reticulum | 2022 |
Using gene expression database to uncover biology functions of 1,4-disubstituted 1,2,3-triazole analogues synthesized via a copper (I)-catalyzed reaction.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Copper; Cu | 2017 |
Tributyl phosphate impairs the urea cycle and alters liver pathology and metabolism in mice after short-term exposure based on a metabonomics study.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinoma, Hepatocellular; Constitutive Androstane Receptor; | 2017 |
Interaction of hepatic stellate cells with neutrophils and macrophages in the liver following oncogenic kras activation in transgenic zebrafish.
Topics: Animals; Animals, Genetically Modified; Hepatic Stellate Cells; Hepatocytes; Indoles; Liver; Liver N | 2018 |
Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion.
Topics: Adult; Aged; Arginine; Blood Vessels; Carcinoma, Hepatocellular; Cholesterol; Fatty Acids; Female; G | 2019 |
Simultaneous recovery of dual pathways for ammonia metabolism do not improve further detoxification of ammonia in HepG2 cells.
Topics: Ammonia; Arginase; Biotransformation; Cell Cycle; Cell Proliferation; Gene Expression Regulation, En | 2013 |
Manipulating hepatocellular carcinoma cell fate in orthogonally cross-linked hydrogels.
Topics: Carcinoma, Hepatocellular; Cell Dedifferentiation; Cell Line, Tumor; Cell Survival; Cells, Immobiliz | 2014 |
Novel all trans-retinoic Acid derivatives: cytotoxicity, inhibition of cell cycle progression and induction of apoptosis in human cancer cell lines.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line; Cell Line, Tu | 2015 |
Indoline ureas as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro biological evaluation and molecular docking.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Dose-Response Relationship, Dr | 2015 |
Reply to F.V. Negri et al.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Emulsions; Female; Hand-Foot Syndrome; Humans; Liv | 2015 |
Urea-Based Cream to Prevent Sorafenib-Induced Hand-and-Foot Skin Reaction: Which Evidence?
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Emulsions; Female; Hand-Foot Syndrome; Humans; Liv | 2015 |
Brewers' Rice: A By-Product from Rice Processing Provides Natural Hepatorenal Protection in Azoxymethane-Induced Oxidative Stress in Rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Azoxymethane; Carc | 2015 |
Culture and Functional Characterization of Human Hepatoma HepG2 Cells.
Topics: Carcinoma, Hepatocellular; Cell Culture Techniques; Cytochrome P-450 Enzyme System; Glutathione Tran | 2015 |
Targeting protein arginine methyltransferase 5 inhibits human hepatocellular carcinoma growth via the downregulation of beta-catenin.
Topics: Animals; Apoptosis; beta Catenin; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Move | 2015 |
Aminopeptidase N inhibitor 4cc synergizes antitumor effects of 5-fluorouracil on human liver cancer cells through ROS-dependent CD13 inhibition.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; CD13 | 2015 |
Hand foot skin reaction in cancer patients treated with the multikinase inhibitors sorafenib and sunitinib.
Topics: Administration, Topical; Aged; Aged, 80 and over; Antineoplastic Agents; Benzenesulfonates; Carcinom | 2008 |
Modulation of morphology and functions of human hepatoblastoma cells by nano-grooved substrata.
Topics: Albumins; Cell Line, Tumor; Cell Shape; Cytoskeleton; Fluorescent Antibody Technique; Hepatoblastoma | 2009 |
Human liver progenitor cell lines are readily established from non-tumorous tissue adjacent to hepatocellular carcinoma.
Topics: AC133 Antigen; Adult Stem Cells; Animals; Antigens, CD; Antigens, Differentiation; Antigens, Neoplas | 2010 |
Alginate-encapsulated human hepatoma C3A cells for use in a bioartificial liver device - the hybrid-MDS.
Topics: Albumins; Alginates; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chromatography | 2009 |
The study of specific and nonspecific hepatoma cells behavior by means of plasma-treated substrates.
Topics: Biocompatible Materials; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Differentiation; C | 2010 |
DNA methylation suppresses expression of the urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) in human hepatocellular carcinoma.
Topics: Carbamoyl-Phosphate Synthase (Ammonia); Carcinoma, Hepatocellular; Cell Line, Tumor; CpG Islands; DN | 2011 |
Is percutaneous microwave ablation of liver tumor safe for patients with renal dysfunction.
Topics: Adult; Aged; Catheter Ablation; Creatinine; Female; Humans; Kidney; Kidney Function Tests; Liver Neo | 2011 |
A translational study "case report" on the small molecule "energy blocker" 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside.
Topics: Adolescent; Ammonia; Antineoplastic Agents, Alkylating; Carcinoma, Hepatocellular; Energy Metabolism | 2012 |
t-AUCB, an improved sEH inhibitor, suppresses human glioblastoma cell growth by activating NF-κB-p65.
Topics: Apoptosis; Benzoates; Blotting, Western; Brain Neoplasms; Carcinoma, Hepatocellular; Cell Cycle; Cel | 2012 |
Synthesis and biological activity of carbocyclic lexitropsins with a bioreductive fragment.
Topics: Antineoplastic Agents; Benzamides; Carcinoma, Hepatocellular; Cell Survival; Humans; Liver Neoplasms | 2002 |
Inhibition of microtubule polymerization by 3-bromopropionylamino benzoylurea (JIMB01), a new cancericidal tubulin ligand.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cyclin B; Cyclin B | 2003 |
Histamine formation and tumor growth.
Topics: Animals; Carcinoma, Hepatocellular; Dihydroxyphenylalanine; Histamine; Liver Neoplasms; Liver Neopla | 1962 |
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: MISCELLANEOUS TUMORS.
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Carcinom | 1964 |
Improvement of C3A cell metabolism for usage in bioartificial liver support systems.
Topics: Albumins; Animals; Cell Line, Tumor; Cells, Cultured; Culture Media; Galactose; Gluconeogenesis; Hep | 2004 |
Ornithine transcarbamylase and arginase I deficiency are responsible for diminished urea cycle function in the human hepatoblastoma cell line HepG2.
Topics: Arginase; Base Sequence; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Primers; Gene Expression; | 2007 |
Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells.
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Carcinoma, Hepatocellular; Cell Line, Tu | 2007 |
Effect of major liver resection on hepatic ureagenesis in humans.
Topics: Adult; Aged; Amino Acids; Ammonia; Blood Flow Velocity; Hepatectomy; Humans; Indocyanine Green; Live | 2007 |
Arginase release by primary hepatocytes and liver slices results in rapid conversion of arginine to urea in cell culture media.
Topics: Animals; Arginase; Arginine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Cells, Cult | 2008 |
Protein complexes of intermediate-sized filaments: melting of cytokeratin complexes in urea reveals different polypeptide separation characteristics.
Topics: Animals; Breast Neoplasms; Carcinoma, Hepatocellular; Cattle; Cell Line; Cytoskeleton; Electrophores | 1983 |
Regulation of urea cycle enzymes in transplantable hepatomas and in the livers of tumor-bearing rats and humans.
Topics: Animals; Betamethasone; Bucladesine; Carcinoma, Hepatocellular; Cell Line; Dietary Proteins; Enzyme | 1981 |
Eleven years experience of oral urea treatment in liver malignancies.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Carcinoma, Hepatocellular; Drug Administration Sc | 1981 |
Oral urea in the treatment of colo-rectal liver metastases.
Topics: Administration, Oral; Colonic Neoplasms; Drug Evaluation; Humans; Liver Neoplasms; Rectal Neoplasms; | 1984 |
Tumor induction by a single subcutaneous injection of 1-butyl-1-nitrosourea or 1-butylurea in newborn mice.
Topics: Adenocarcinoma; Adenoma; Animals; Animals, Newborn; Carcinogens; Female; Injections, Subcutaneous; L | 1983 |
Urea--treatment of liver metastases.
Topics: Female; Humans; Liver Neoplasms; Male; Urea | 1981 |
[A new liver support system composed of functional human cells and a radial-flow bioreactor].
Topics: Albumins; alpha-Fetoproteins; Ammonia; Artificial Organs; Carcinoma, Hepatocellular; Cells, Cultured | 1994 |
Clinical and pathological studies in horses with hepatic disease.
Topics: Ammonia; Animals; Bile Acids and Salts; Bilirubin; Biopsy; Blood Glucose; Disease Progression; Femal | 1996 |
Effects of dexamethasone and interleukin-6 on urea production by human hepatocytes in vitro.
Topics: Carcinoma, Hepatocellular; Cell Survival; Cells, Cultured; Dexamethasone; Humans; Interleukin-6; Kin | 1997 |
Metabolic capacities in cultured human hepatocytes obtained by a new isolating procedure from non-wedge small liver biopsies.
Topics: Adult; Aged; Aged, 80 and over; Albumins; Biopsy; Blotting, Western; Carcinoma, Hepatocellular; Cell | 1998 |
Immobilization of ligand-modified polyamidoamine dendrimer for cultivation of hepatoma cells.
Topics: Animals; Azirines; Benzoates; Cell Adhesion; Cell Division; Cell Membrane; Cell Survival; Cells, Imm | 2000 |
Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2.
Topics: Albumins; Ammonia; Biotransformation; Cell Count; Cell Differentiation; Cell Division; Cell Size; Cy | 2001 |
Heterogeneity of human alpha-fetoprotein as revealed by isoelectric focusing in urea-containing gels.
Topics: alpha-Fetoproteins; Carcinoma, Hepatocellular; Electrophoresis, Polyacrylamide Gel; Genetic Variatio | 1978 |
Dissociation and reconstitution of chromatin without appreciable degradation of the proteins.
Topics: Animals; Carcinoma, Hepatocellular; Chromatin; DNA-Directed RNA Polymerases; Electrophoresis, Polyac | 1975 |
Sulfhydryl group quantitation of hepatoma and liver microsomal fractions.
Topics: Age Factors; Animals; Carcinoma, Hepatocellular; Cell Fractionation; Disulfides; Edetic Acid; Endopl | 1975 |
Tumor-specific alkaline phosphatase in hepatoma.
Topics: Adult; Alkaline Phosphatase; Carcinoma, Hepatocellular; Edetic Acid; Female; Fetus; Humans; Imidazol | 1975 |
The results of urea-treatment in liver maligancies.
Topics: Administration, Oral; Adult; Aged; Carcinoma, Hepatocellular; Female; Humans; Liver Neoplasms; Male; | 1975 |
Urea synthesis in Novikoff and Morris hepatomas.
Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Carcinoma, Hepatocellular; Fasting; Liver; Liver Ne | 1977 |
Increased de novo pyrimidine nucleotide synthesis in liver induced by ammonium ions in amounts surpassing the urea cycle capacity.
Topics: Animals; Azauridine; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase (Glutamine | 1977 |
Characterization and subunit analysis of ferritin isolated from normal and malignant human liver.
Topics: Carcinoma, Hepatocellular; Chemical Phenomena; Chemistry; Chromatography, Gel; Electrophoresis, Poly | 1975 |
Nuclear protein changes in rat hepatomas correlating with growth rate.
Topics: Acetates; Animals; Carcinoma, Hepatocellular; Chick Embryo; Densitometry; Electrophoresis, Polyacryl | 1975 |
Urea in the management of advanced malignancies (preliminary report).
Topics: Adenocarcinoma; Bone Neoplasms; Carcinoma, Squamous Cell; Female; Fever; Humans; Liver Neoplasms; Ma | 1977 |
Nitrogen-stimulated orotic acid synthesis and nucleotide imbalance.
Topics: Ammonia; Animals; Carbamyl Phosphate; Cattle; Humans; Liver Neoplasms; Milk; Orotic Acid; Pyrimidine | 1992 |
Kinetic modeling of in vivo--nuclear magnetic resonance spectroscopy data: 5-fluorouracil in liver and liver tumors.
Topics: Adult; Aged; beta-Alanine; Female; Fluorine; Fluorouracil; Humans; Least-Squares Analysis; Liver; Li | 1991 |
Tumor promoting activities of ethylphenylacetylurea and diethylacetylurea, the ring hydrolysis products of barbiturate tumor promoters phenobarbital and barbital, in rat liver and kidney initiated by N-nitrosodiethylamine.
Topics: Animals; Barbital; Body Weight; Carcinogens; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enz | 1989 |
Oral urea in the treatment of secondary tumours in the liver.
Topics: Administration, Oral; Aged; Drug Evaluation; Female; Humans; Liver Neoplasms; Male; Middle Aged; Ure | 1988 |
Oral urea in treatment of liver metastases from colorectal adenocarcinoma.
Topics: Adenocarcinoma; Administration, Oral; Aged; Colonic Neoplasms; Drug Evaluation; Female; Humans; Live | 1987 |
Nitrogen metabolism and lipid peroxidation during hyperthermic perfusion of human livers with cancer.
Topics: Amino Acids; Calcium; Creatinine; Humans; Hyperthermia, Induced; Lipid Peroxides; Liver Neoplasms; L | 1986 |
Recurrent hyperparathyroidism due to parathyroid carcinoma.
Topics: Adenoma; Adult; Autopsy; Calcium; Female; Humans; Hypercalcemia; Hyperparathyroidism; Hyperplasia; H | 1971 |
A comparative study of the protein components of ribonucleoprotein particles isolated from rat liver and hepatoma nuclei.
Topics: Animals; Carcinoma, Hepatocellular; Cell Nucleus; Electrophoresis, Polyacrylamide Gel; Liver; Liver | 1973 |
Letter: Regression of liver cancer with oral urea.
Topics: Administration, Oral; Aged; Carcinoma, Hepatocellular; Female; Humans; Liver Neoplasms; Male; Middle | 1974 |
Treatment of ascites by continuous ultrafiltration and reinfusion of protein concentrate.
Topics: Adolescent; Adult; Aged; Albumins; Alcoholism; Ascites; Ascitic Fluid; Automation; Chlorides; Female | 1974 |
Establishment of a clonal strain of hepatoma cells which maintain in culture the five enzymes of the urea cycle.
Topics: Ammonia; Animals; Arginase; Arginine; Bucladesine; Carbamates; Carcinoma, Hepatocellular; Chromosome | 1974 |
Combination chemotherapy in gastrointestinal cancer.
Topics: Adenocarcinoma; Adult; Alopecia; Appendiceal Neoplasms; Diarrhea; Drug Eruptions; Fluorouracil; Gall | 1970 |
[Intensity of glycolysis and activity of enzymes regulating it in hepatic hyaloplasm in the rat in administration of hepatocarcinogens and the herbicide Monuron].
Topics: Amides; Animals; Carcinogens; Chemical and Drug Induced Liver Injury; Glycolysis; Herbicides; Hexoki | 1970 |
Effect of azo-dye carcinogenesis on enzymes concerned with urea synthesis in rat liver.
Topics: Animals; Arginase; Carcinogens; Carcinoma, Hepatocellular; Glucosephosphate Dehydrogenase; Ligases; | 1964 |
Studies on the function of intracellular ribonucleases. V. Ribonuclease activity in ribosomes and polysomes prepared from rat liver and hepatomas.
Topics: Animals; Carcinoma, Hepatocellular; Centrifugation, Density Gradient; Edetic Acid; Hydrogen-Ion Conc | 1966 |
Subtotal hepatectomy for primary hepatic carcinoma.
Topics: Adolescent; Bilirubin; Carcinoma, Hepatocellular; Cholestasis; Female; Hepatectomy; Humans; Liver Ab | 1967 |
Stability of nucleolar 45-S RNA.
Topics: Animals; Carcinoma, Hepatocellular; Cell Nucleolus; Centrifugation, Density Gradient; Hydrogen-Ion C | 1967 |
Investigation of albumin metabolism in man.
Topics: Amino Acids; Carbon Isotopes; Carcinoma, Hepatocellular; Celiac Disease; Humans; Hypertension; Liver | 1967 |
Azathioprine (Imuran) administration and the development of malignant lymphomas in NZB mice.
Topics: Albuminuria; Anemia, Hemolytic, Autoimmune; Animals; Azathioprine; Coombs Test; Glomerulonephritis; | 1968 |
(Mg2+ Na+ K+)-ATPase activity of liver from tumor bearing rats.
Topics: Adenosine Triphosphatases; Animals; Binding Sites; Carcinoma, Hepatocellular; Enzyme Activation; Hyd | 1969 |
Toxicity, tissue changes, and tumor induction in inbred Swiss mice by methylnitrosamine and -amide compounds.
Topics: Adenoma; Animals; Animals, Newborn; Blood Cell Count; Bone Marrow; Bone Marrow Cells; Carcinoma, Hep | 1970 |
Carcinogenicity of a single administration of N-nitrosomethylurea: a comparison between newborn and 5-week-old mice and rats.
Topics: Adenoma; Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Female; Gastrointestinal | 1970 |
[The cancer-risk in man from synthetic sweetening agents].
Topics: Animals; Carcinoma, Hepatocellular; Cyclamates; Female; Liver Neoplasms; Lung Neoplasms; Lymphoma, N | 1971 |
A circular dichroism study on the conformation of DNA in rat liver chromatin.
Topics: Animals; Ascitic Fluid; Carcinoma, Hepatocellular; Cell Line; Chemical Phenomena; Chemistry; Chromos | 1971 |
Some aspects of the mechanism of action of 1-propyl-1-nitrosourea.
Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular | 1970 |
Further studies on streptozotocin therapy for a multiple-hormone-producing islet cell carcinoma.
Topics: Acetoacetates; Adenoma, Islet Cell; Antibiotics, Antineoplastic; Autopsy; Blood Glucose; Diabetes In | 1971 |
Notes on streptozotocin in metastatic insulinoma.
Topics: Adenoma, Islet Cell; Adult; Antibiotics, Antineoplastic; Autopsy; Blood Glucose; Bone Marrow; Brain; | 1971 |
A study of various electrophoretic and inhibition techniques for separating serum alkaline phosphatase isoenzymes.
Topics: Acrylamides; Alkaline Phosphatase; Bile; Bone and Bones; Buffers; Carcinoma, Hepatocellular; Clinica | 1972 |
Histone phosphorylation and DNA synthesis are linked in synchronous cultures of HTC cells.
Topics: Benzocycloheptenes; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; DNA; Electrophoresis; His | 1972 |
Lysine-rich histone phosphorylation. A positive correlation with cell replication.
Topics: Alkaline Phosphatase; Animals; Carcinoma, Hepatocellular; Cell Division; Cell Line; Densitometry; El | 1972 |
Effect of neuraminic acid removal on the properties of a variant alkaline phosphatase in hepatoma.
Topics: Alkaline Phosphatase; Aminocaproates; Carcinoma, Hepatocellular; Edetic Acid; Enzyme Activation; Gen | 1972 |
Studies on a variant alkaline phosphatase in sera of patients with hepatocellular carcinoma.
Topics: Acrylamides; Alkaline Phosphatase; Amino Acids; Animals; Antibody Specificity; Carcinoma, Hepatocell | 1972 |
Turnover of deoxyribonucleic acid, histones, and lysine-rich histone phosphate in hepatoma tissue culture cells.
Topics: Carcinoma, Hepatocellular; Cell Line; DNA, Neoplasm; Electrophoresis, Polyacrylamide Gel; Half-Life; | 1972 |
Molecular nature of F 1 histone phosphorylation in cultured hepatoma cells.
Topics: Carcinoma, Hepatocellular; Cell Line; Electrophoresis, Polyacrylamide Gel; Histones; Isotope Labelin | 1972 |
[Ornithine-carbamoyl-transferase and its clinical valve].
Topics: Ammonia; Carbon Dioxide; Carcinoma, Hepatocellular; Clinical Enzyme Tests; Hepatitis A; Jaundice; Li | 1972 |
Protein turnover in microsomal subfractions of liver and Morris hepatomas 7800 and 9618A.
Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Centrifugation, Density Gradient; Cholesterol; | 1973 |
Inhibition of urea on the hepatocarcinogensis induced by N, N-dimethyl-4-aminoazobenzene in rats.
Topics: Animals; Carcinoma, Hepatocellular; Female; Liver Neoplasms; p-Dimethylaminoazobenzene; Rats; Urea | 1973 |
Further investigation of a variant of the placental alkaline phosphatase in human hepatic carcinoma.
Topics: Alkaline Phosphatase; Animals; Carcinoma, Hepatocellular; Chromatography, Gel; Cross Reactions; Edet | 1974 |
Nuclear protein changes during the nitrosamine-induced carcinogenesis of rat liver.
Topics: Animals; Binding Sites; Carbon Radioisotopes; Carcinogens; Carcinoma, Hepatocellular; Cell Nucleus; | 1974 |
Multiple carcinogenic effects of the ethylnitrosourea precursors ethylurea and sodium nitrite in hamsters.
Topics: Age Factors; Animals; Carcinogens; Carcinoma, Squamous Cell; Cricetinae; Female; Liver Neoplasms; Ma | 1974 |
[Two simple methods for lactate dehydrogenase isoenzyme determination in liver diseases].
Topics: Cholestasis; Clinical Enzyme Tests; Hepatitis A; Humans; Hydroxybutyrate Dehydrogenase; Isoenzymes; | 1973 |
Effect of 1, 3-diallylurea and related compounds on growth of transplanted animal tumors.
Topics: Animals; Antineoplastic Agents; Carcinoma; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Female; | 1967 |
Combination chemotherapy in malignant melanoma.
Topics: Adult; Bone Marrow Examination; Bone Neoplasms; Brain Neoplasms; Female; Hemoglobins; Humans; Inject | 1970 |
Inhibition of lactate dehydrogenase isoenzymes activity by potassium oxalate and urea in some liver diseases.
Topics: Adult; Aged; Atrophy; Cholelithiasis; Clinical Enzyme Tests; Diagnosis, Differential; Female; Hepati | 1968 |
Use of urea denaturation in the identification of human alkaline phosphatases.
Topics: Alkaline Phosphatase; Automation; Bone and Bones; Bone Diseases; Cholestasis; Clinical Enzyme Tests; | 1968 |
Impaired ammonia metabolism in severe hepatic disease.
Topics: Ammonia; Glycine; Humans; Injections, Intravenous; Liver Cirrhosis; Liver Neoplasms; Time Factors; U | 1969 |
On the DNA and histone content of N-nitrosomethylurea induced rat tumours.
Topics: Adenoma; Aneuploidy; Animals; Brain Neoplasms; Bronchial Neoplasms; Carcinoma; DNA; DNA, Neoplasm; F | 1969 |