urea has been researched along with Ache in 92 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A double-blind cross-over study using a double placebo technique was employed to compare the effectiveness of daily alclofenac 3 g and phenylbutazone 300 mg in rheumatoid arthritis." | 9.04 | A double blind trial to assess the value of alclofenac compared with phenylbutazone in the management of rheumatoid arthritis. ( Chamberlain, MA; Wright, V, 1975) |
| " In this study, to investigate the antinociceptive effects and the analgesic profile of landiolol, we examined the effects of intrathecal landiolol administration on nociceptive pain behavior and c-fos mRNA expression (a neural marker of pain) in the spinal cord using a rat formalin model." | 7.78 | Antinociceptive effects of intrathecal landiolol injection in a rat formalin pain model. ( Itano, Y; Kaku, R; Kanzaki, H; Matsuoka, Y; Mizobuchi, S; Morita, K; Nishie, H; Obata, N; Ouchida, M; Taniguchi, A; Tomotsuka, N, 2012) |
| " This novel sEH inhibitor showed a 1000-fold increase in potency when compared to morphine by reducing hyperalgesia as measured by mechanical withdrawal threshold using the in vivo carrageenan induced inflammatory pain model." | 7.76 | 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. ( Hammock, BD; Inceoglu, B; Jones, PD; Liu, JY; Morisseau, C; Rose, TE; Sanborn, JR, 2010) |
| "Severe stress results in a catabolic state with nitrogen (N) loss via hepatic urea synthesis, and in most situations a sensation of pain." | 7.70 | Acute non-traumatic pain increases the hepatic amino- to urea-N conversion in normal man. ( Greisen, J; Grøfte, T; Hansen, PO; Jensen, TS; Vilstrup, H, 1999) |
| " Almost half of the patients taking aspirin were unable to tolerate the drug in adequate dosage for six months." | 6.64 | Treatment of rheumatoid arthritis with fenoprofen: comparison with aspirin. ( Balme, HW; Berry, H; Hart, FD; Huskisson, EC; Scott, J; Wojtulewski, JA, 1974) |
| " Alkylated compounds showed weaker in vitro potencies in blocking capsaicin activation of TRPV1 receptor, but possessed improved pharmacokinetic properties." | 5.34 | Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model. ( Bayburt, EK; Didomenico, S; Drizin, I; Faltynek, CR; Gomtsyan, A; Honore, P; Jinkerson, TK; Keddy, R; Koenig, JR; Lee, CH; Marsh, KC; McDonald, HA; Mikusa, J; Perner, RJ; Surowy, CS; Turner, SC; Wetter, JM, 2007) |
| " Furthermore, A-425619 maintained efficacy in the postoperative pain model after twice daily dosing p." | 5.33 | A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats. ( El Kouhen, R; Faltynek, CR; Gauvin, DM; Gomtsyan, A; Honore, P; Jarvis, MF; Lee, CH; Marsh, K; Mikusa, J; Sullivan, JP; Wismer, CT; Zhong, C; Zhu, CZ, 2005) |
| " The 5-isoquinoline-containing compound 14a (hTRPV1 IC50 = 4 nM) exhibited 46% oral bioavailability and in vivo activity in animal models of visceral and inflammatory pain." | 5.33 | Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties. ( Bayburt, EK; Didomenico, S; Drizin, I; Faltynek, CR; Gomtsyan, A; Hannick, SM; Honore, P; Jarvis, MF; Jinkerson, T; Koenig, JR; Lee, CH; Macri, BS; Marsh, KC; McDonald, HA; Oie, T; Perner, RJ; Schmidt, RG; Stewart, KD; Surowy, CS; Turner, S; Wetter, J; Wismer, CT; Zheng, GZ, 2005) |
| "A double-blind cross-over study using a double placebo technique was employed to compare the effectiveness of daily alclofenac 3 g and phenylbutazone 300 mg in rheumatoid arthritis." | 5.04 | A double blind trial to assess the value of alclofenac compared with phenylbutazone in the management of rheumatoid arthritis. ( Chamberlain, MA; Wright, V, 1975) |
| " Previously, we demonstrated that DAGLβ inactivation using the triazole urea inhibitor KT109 blocked macrophage inflammatory signaling and reversed allodynic responses of mice in inflammatory and neuropathic pain models." | 3.88 | Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo. ( Donvito, G; Fox, TE; Hsu, KL; Kester, M; Lichtman, AH; Schurman, LD; Shin, M; Snyder, HW, 2018) |
| "Carbachol attenuated formalin-induced biphasic pain responses and SB-334867 or TCS OX2 29 administration dose-dependently antagonized the LH-induced analgesia during both phases." | 3.83 | Differential contribution of orexin receptors within the ventral tegmental area to modulation of persistent inflammatory pain. ( Babapour, V; Ezzatpanah, S; Haghparast, A, 2016) |
| "Chemical stimulation of the lateral hypothalamus (LH) with carbachol induces antinociception which is antagonized by blockade of orexin receptors in some pain modulatory sites in the tail-flick test." | 3.83 | Functional interaction between orexin-1 and CB1 receptors in the periaqueductal gray matter during antinociception induced by chemical stimulation of the lateral hypothalamus in rats. ( Esmaeili, MH; Ezzatpanah, S; Haghparast, A; Reisi, Z, 2016) |
| "A series of piperazine ureas were designed, synthesized, and evaluated for their potential as novel orally efficacious fatty acid amide hydrolase (FAAH) inhibitors for the treatment of neuropathic and inflammatory pain." | 3.80 | Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors. ( Fujimoto, S; Imaeda, T; Kawamura, T; Kono, M; Kori, M; Kosugi, Y; Matsui, H; Matsumoto, T; Odani, T; Shimizu, Y; Shimojo, M, 2014) |
| "A series of piperazine ureas was designed, synthesized, and evaluated for their potential as novel orally available fatty acid amide hydrolase (FAAH) inhibitors that are therapeutically effective against pain." | 3.79 | Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors. ( Behnke, CA; Igaki, S; Kawamura, T; Kiyota, Y; Kono, M; Kori, M; Matsumoto, T; Miyazaki, J; Nishimura, A; Oki, H; Shimojo, M, 2013) |
| " In this study, to investigate the antinociceptive effects and the analgesic profile of landiolol, we examined the effects of intrathecal landiolol administration on nociceptive pain behavior and c-fos mRNA expression (a neural marker of pain) in the spinal cord using a rat formalin model." | 3.78 | Antinociceptive effects of intrathecal landiolol injection in a rat formalin pain model. ( Itano, Y; Kaku, R; Kanzaki, H; Matsuoka, Y; Mizobuchi, S; Morita, K; Nishie, H; Obata, N; Ouchida, M; Taniguchi, A; Tomotsuka, N, 2012) |
| " In all models, URB937 was as effective or more effective than standard analgesic and anti-inflammatory drugs (indomethacin, gabapentin, dexamethasone) and reversed pain-related responses (mechanical hyperalgesia, thermal hyperalgesia, and mechanical allodynia) in a dose-dependent manner." | 3.78 | Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. ( Armirotti, A; Bandiera, T; Bertorelli, R; Colombano, G; Moreno-Sanz, G; Piomelli, D; Reggiani, A; Sasso, O; Scarpelli, R, 2012) |
| " This novel sEH inhibitor showed a 1000-fold increase in potency when compared to morphine by reducing hyperalgesia as measured by mechanical withdrawal threshold using the in vivo carrageenan induced inflammatory pain model." | 3.76 | 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. ( Hammock, BD; Inceoglu, B; Jones, PD; Liu, JY; Morisseau, C; Rose, TE; Sanborn, JR, 2010) |
| " A number of VPA analogues and their amide, N-methylamide and urea derivatives, were synthesized and evaluated in animal models of neuropathic pain and epilepsy." | 3.75 | Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues. ( Bialer, M; Devor, M; Kaufmann, D; Shimshoni, JA; Yagen, B, 2009) |
| "Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH." | 3.73 | TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists. ( Bayburt, EK; Bianchi, B; Brown, B; Chandran, P; Cui, M; Decker, MW; Faltynek, CR; Gauvin, D; Gomtsyan, A; Hernandez, G; Honore, P; Lee, CH; Marsh, K; McDonald, H; Mikusa, J; Moreland, RB; Neelands, TR; Niforatos, W; Sullivan, JP; Zhong, C, 2006) |
| "Severe stress results in a catabolic state with nitrogen (N) loss via hepatic urea synthesis, and in most situations a sensation of pain." | 3.70 | Acute non-traumatic pain increases the hepatic amino- to urea-N conversion in normal man. ( Greisen, J; Grøfte, T; Hansen, PO; Jensen, TS; Vilstrup, H, 1999) |
| "Non-oliguric renal failure developed in six elderly women who had been prescribed 1--2 g of mefenamic acid daily for 2--6 weeks for the relief of musculoskeletal pain." | 3.66 | Mefenamic acid nephropathy. ( Dlugolecka, M; Ford, MJ; Prescott, LF; Robertson, CE; Van Someren, V, 1980) |
| "Incidences of arrhythmia, muscular cramps and headache were significantly less frequent during HF." | 2.68 | On-line predilution hemofiltration versus ultrapure high-flux hemodialysis: a multicenter prospective study in 23 patients. Sardinian Collaborative Study Group of On-Line Hemofiltration. ( Altieri, P; Asproni, E; Bolasco, F; Bolasco, PG; Bostrom, M; Cabiddu, GF; Cadinu, F; Casu, D; Cossu, M; Ferrara, R; Ganadu, M; Passaghe, M; Pinna, M; Sorba, GB, 1997) |
| " Almost half of the patients taking aspirin were unable to tolerate the drug in adequate dosage for six months." | 2.64 | Treatment of rheumatoid arthritis with fenoprofen: comparison with aspirin. ( Balme, HW; Berry, H; Hart, FD; Huskisson, EC; Scott, J; Wojtulewski, JA, 1974) |
| "Pain was induced by formalin (2%) injection into the hind paw." | 1.42 | Microinjection of orexin-A into the rat locus coeruleus nucleus induces analgesia via cannabinoid type-1 receptors. ( Ali Reza, M; Azizi, H; Mirnajafi-Zadeh, J; Mohammad-Pour Kargar, H; Semnanian, S, 2015) |
| "Pain is the leading cause of emergency department visits, hospitalizations, and daily suffering in individuals with sickle cell disease (SCD)." | 1.37 | Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease. ( Barabas, ME; Brandow, AM; Hillery, CA; Kerstein, PC; Retherford, D; Stucky, CL; Vilceanu, D; Wandersee, NJ, 2011) |
| "Assessment of RTX hyperalgesia by measurement of the paw withdrawal latency with a plantar test apparatus yielded 30 mg/kg minimum effective dose for each antagonist." | 1.36 | Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath. ( Bölcskei, K; Dézsi, L; Horváth, C; Kis-Varga, A; Petho, G; Szentirmay, E; Szolcsányi, J; Tékus, V; Visegrády, A, 2010) |
| " Although a single dose of ABT-102 produced a self-limiting increase in core body temperature that remained in the normal range, the hyperthermic effects of ABT-102 effectively tolerated following twice-daily dosing for 2 days." | 1.35 | Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia. ( Banfor, PN; Bayburt, E; Chandran, P; Daanen, JF; Faltynek, CR; Fryer, RM; Gauvin, DM; Ghilardi, JR; Gomtsyan, A; Hernandez, G; Honore, P; Jarvis, MF; Joshi, SK; Kort, ME; Kym, PR; Lee, CH; Mantyh, PW; Marsh, K; Mikusa, JP; Neelands, T; Reilly, RM; Segreti, JA; Sevcik, MA; Sullivan, JP; Surowy, CS; Zhong, C, 2009) |
| " However, their long-term use has been associated with considerable morbidity, limiting their application." | 1.35 | Effect of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles on chronic inflammatory pain model in rats. ( Beck, P; Bonacorso, HG; Duarte, MM; Ferreira, J; Machado, P; Martins, MA; Mello, CF; Rubin, MA; Sant'Anna, Gda S; Sauzem, PD; Zanatta, N, 2009) |
| "This sensitisation reached a maximum in 60-90 min, at which time responses had risen to approximately twice that of control levels seen before the application of inflammatory soup." | 1.35 | The effects of the TRPV1 receptor antagonist SB-705498 on trigeminovascular sensitisation and neurotransmission. ( Appleby, JM; Chizh, BA; Davis, JB; Hoskin, KL; Lambert, GA; Zagami, AS, 2009) |
| " Alkylated compounds showed weaker in vitro potencies in blocking capsaicin activation of TRPV1 receptor, but possessed improved pharmacokinetic properties." | 1.34 | Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model. ( Bayburt, EK; Didomenico, S; Drizin, I; Faltynek, CR; Gomtsyan, A; Honore, P; Jinkerson, TK; Keddy, R; Koenig, JR; Lee, CH; Marsh, KC; McDonald, HA; Mikusa, J; Perner, RJ; Surowy, CS; Turner, SC; Wetter, JM, 2007) |
| " Furthermore, A-425619 maintained efficacy in the postoperative pain model after twice daily dosing p." | 1.33 | A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats. ( El Kouhen, R; Faltynek, CR; Gauvin, DM; Gomtsyan, A; Honore, P; Jarvis, MF; Lee, CH; Marsh, K; Mikusa, J; Sullivan, JP; Wismer, CT; Zhong, C; Zhu, CZ, 2005) |
| " The resulting aminoquinazoline 70 represents a novel VR1 antagonist with improved in vitro potency and oral bioavailability vs the analogous compounds from the lead series." | 1.33 | From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist. ( Bakthavatchalam, R; Blum, CA; Blurton, P; Brian Jones, A; Brielmann, H; Burkamp, F; Chandrasekhar, J; Clarkson, R; Cortright, D; Crandall, M; De Lombaert, S; Hodgetts, KJ; Hutchison, A; Zheng, X, 2006) |
| " The 5-isoquinoline-containing compound 14a (hTRPV1 IC50 = 4 nM) exhibited 46% oral bioavailability and in vivo activity in animal models of visceral and inflammatory pain." | 1.33 | Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties. ( Bayburt, EK; Didomenico, S; Drizin, I; Faltynek, CR; Gomtsyan, A; Hannick, SM; Honore, P; Jarvis, MF; Jinkerson, T; Koenig, JR; Lee, CH; Macri, BS; Marsh, KC; McDonald, HA; Oie, T; Perner, RJ; Schmidt, RG; Stewart, KD; Surowy, CS; Turner, S; Wetter, J; Wismer, CT; Zheng, GZ, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (25.00) | 18.7374 |
| 1990's | 3 (3.26) | 18.2507 |
| 2000's | 28 (30.43) | 29.6817 |
| 2010's | 27 (29.35) | 24.3611 |
| 2020's | 11 (11.96) | 2.80 |
| Authors | Studies |
|---|---|
| Zareie, F | 1 |
| Ghalebandi, S | 1 |
| Askari, K | 1 |
| Mousavi, Z | 1 |
| Haghparast, A | 4 |
| Tian, Y | 2 |
| Li, S | 2 |
| Yang, P | 1 |
| Su, X | 2 |
| Liu, J | 2 |
| Lv, X | 2 |
| Dong, K | 2 |
| Yang, T | 2 |
| Duan, M | 2 |
| Hu, G | 2 |
| Yue, H | 2 |
| Sun, Y | 4 |
| Zhang, H | 2 |
| Du, Z | 2 |
| Miao, Z | 2 |
| Tong, M | 2 |
| Hou, Y | 2 |
| Gao, Z | 2 |
| Zhao, Y | 2 |
| Fu, S | 1 |
| Han, Y | 1 |
| Liu, Y | 1 |
| Qin, M | 1 |
| Gong, P | 1 |
| Butler, JR | 1 |
| Rescourio, G | 1 |
| Milgram, BC | 1 |
| Foti, RS | 1 |
| Kornecook, T | 1 |
| Ligutti, J | 1 |
| Moyer, BD | 1 |
| Taborn, K | 1 |
| Youngblood, BD | 1 |
| Yu, V | 1 |
| Shimanovich, R | 1 |
| Boezio, A | 1 |
| Weiss, M | 1 |
| Shang, Y | 1 |
| Wang, M | 1 |
| Hao, Q | 1 |
| Meng, T | 1 |
| Li, L | 1 |
| Shi, J | 1 |
| Yang, G | 1 |
| Zhang, Z | 1 |
| Yang, K | 1 |
| Wang, J | 2 |
| Cuttica, DJ | 1 |
| Neufeld, SK | 1 |
| Baird, M | 1 |
| Levy, JA | 1 |
| Spigariolo, CB | 1 |
| Ferrucci, SM | 1 |
| Zhao, Z | 1 |
| Huang, T | 1 |
| Li, J | 1 |
| Spiteri, M | 1 |
| Giele, H | 1 |
| Cagli, A | 1 |
| Senol, SP | 1 |
| Temiz-Resitoglu, M | 1 |
| Guden, DS | 1 |
| Sari, AN | 1 |
| Sahan-Firat, S | 1 |
| Tunctan, B | 1 |
| Hu, J | 1 |
| Gao, M | 1 |
| Zhang, Y | 3 |
| Wang, Y | 2 |
| Qiao, Z | 1 |
| Zhang, W | 1 |
| Wang, Q | 1 |
| Yan, L | 1 |
| Qian, H | 2 |
| Nonaka, T | 1 |
| Yamada, T | 1 |
| Ishimura, T | 1 |
| Zuo, D | 1 |
| Moffett, JR | 1 |
| Neale, JH | 4 |
| Yamamoto, T | 3 |
| Shin, M | 1 |
| Snyder, HW | 1 |
| Donvito, G | 1 |
| Schurman, LD | 1 |
| Fox, TE | 1 |
| Lichtman, AH | 1 |
| Kester, M | 1 |
| Hsu, KL | 1 |
| Rodrigues de Carvalho, AM | 1 |
| Vasconcelos, LF | 1 |
| Moura Rocha, NF | 1 |
| Vasconcelos Rios, ER | 1 |
| Dias, ML | 1 |
| Maria de França Fonteles, M | 1 |
| Gaspar, DM | 1 |
| Barbosa Filho, JM | 1 |
| Chavez Gutierrez, SJ | 1 |
| Florenço de Sousa, FC | 1 |
| Rezaee, L | 1 |
| Karimi-Haghighi, S | 1 |
| Fazli-Tabaei, S | 1 |
| Kono, M | 2 |
| Matsumoto, T | 2 |
| Imaeda, T | 1 |
| Kawamura, T | 2 |
| Fujimoto, S | 1 |
| Kosugi, Y | 1 |
| Odani, T | 1 |
| Shimizu, Y | 1 |
| Matsui, H | 1 |
| Shimojo, M | 2 |
| Kori, M | 2 |
| Haseena banu, B | 1 |
| Prasad, KV | 1 |
| Bharathi, K | 1 |
| Abdelkader, H | 1 |
| Abdallah, OY | 1 |
| Salem, H | 1 |
| Alani, AW | 1 |
| Alany, RG | 1 |
| Qiu, Q | 1 |
| Deng, X | 1 |
| Lin, H | 2 |
| Huang, W | 2 |
| Mohammad-Pour Kargar, H | 1 |
| Azizi, H | 1 |
| Mirnajafi-Zadeh, J | 1 |
| Ali Reza, M | 1 |
| Semnanian, S | 1 |
| Ezzatpanah, S | 2 |
| Babapour, V | 1 |
| Esmaeili, MH | 1 |
| Reisi, Z | 1 |
| Sabow, AB | 1 |
| Goh, YM | 1 |
| Zulkifli, I | 1 |
| Sazili, AQ | 1 |
| Kaka, U | 1 |
| Kadi, MZAA | 1 |
| Ebrahimi, M | 1 |
| Nakyinsige, K | 1 |
| Adeyemi, KD | 1 |
| Manglik, A | 1 |
| Aryal, DK | 1 |
| McCorvy, JD | 1 |
| Dengler, D | 1 |
| Corder, G | 1 |
| Levit, A | 1 |
| Kling, RC | 1 |
| Bernat, V | 1 |
| Hübner, H | 1 |
| Huang, XP | 1 |
| Sassano, MF | 1 |
| Giguère, PM | 1 |
| Löber, S | 1 |
| Scherrer, G | 1 |
| Kobilka, BK | 1 |
| Gmeiner, P | 1 |
| Roth, BL | 1 |
| Shoichet, BK | 1 |
| Kozikowski, A | 2 |
| Zhou, J | 2 |
| Yan, JA | 1 |
| Ge, L | 1 |
| Song, B | 1 |
| Chen, XW | 1 |
| Yu, ZP | 1 |
| Joshi, SK | 2 |
| Honore, P | 7 |
| Hernandez, G | 3 |
| Schmidt, R | 1 |
| Gomtsyan, A | 7 |
| Scanio, M | 1 |
| Kort, M | 1 |
| Jarvis, MF | 5 |
| Chandran, P | 2 |
| Gauvin, DM | 2 |
| Mikusa, JP | 1 |
| Zhong, C | 3 |
| Ghilardi, JR | 1 |
| Sevcik, MA | 1 |
| Fryer, RM | 1 |
| Segreti, JA | 1 |
| Banfor, PN | 1 |
| Marsh, K | 3 |
| Neelands, T | 1 |
| Bayburt, E | 1 |
| Daanen, JF | 1 |
| Lee, CH | 6 |
| Kort, ME | 1 |
| Reilly, RM | 1 |
| Surowy, CS | 4 |
| Kym, PR | 1 |
| Mantyh, PW | 1 |
| Sullivan, JP | 4 |
| Faltynek, CR | 7 |
| Lambert, DG | 1 |
| Ahn, K | 2 |
| Johnson, DS | 2 |
| Mileni, M | 1 |
| Beidler, D | 2 |
| Long, JZ | 1 |
| McKinney, MK | 1 |
| Weerapana, E | 2 |
| Sadagopan, N | 2 |
| Liimatta, M | 1 |
| Smith, SE | 2 |
| Lazerwith, S | 1 |
| Stiff, C | 2 |
| Kamtekar, S | 1 |
| Bhattacharya, K | 1 |
| Swaney, S | 2 |
| Van Becelaere, K | 2 |
| Stevens, RC | 1 |
| Cravatt, BF | 2 |
| Jeong, Y | 1 |
| Holden, JE | 1 |
| Ozcan, M | 1 |
| Ayar, A | 1 |
| Serhatlioglu, I | 1 |
| Alcin, E | 1 |
| Sahin, Z | 1 |
| Kelestimur, H | 1 |
| Sauzem, PD | 1 |
| Sant'Anna, Gda S | 1 |
| Machado, P | 1 |
| Duarte, MM | 1 |
| Ferreira, J | 1 |
| Mello, CF | 1 |
| Beck, P | 1 |
| Bonacorso, HG | 1 |
| Zanatta, N | 1 |
| Martins, MA | 1 |
| Rubin, MA | 1 |
| Xu, X | 1 |
| Zuo, X | 1 |
| Wang, X | 1 |
| Han, S | 1 |
| Lambert, GA | 1 |
| Davis, JB | 1 |
| Appleby, JM | 1 |
| Chizh, BA | 1 |
| Hoskin, KL | 1 |
| Zagami, AS | 1 |
| Kaufmann, D | 1 |
| Bialer, M | 1 |
| Shimshoni, JA | 1 |
| Devor, M | 1 |
| Yagen, B | 1 |
| Watson, SL | 1 |
| Watson, CJ | 1 |
| Baghdoyan, HA | 1 |
| Lydic, R | 1 |
| Tékus, V | 1 |
| Bölcskei, K | 1 |
| Kis-Varga, A | 1 |
| Dézsi, L | 1 |
| Szentirmay, E | 1 |
| Visegrády, A | 1 |
| Horváth, C | 1 |
| Szolcsányi, J | 1 |
| Petho, G | 1 |
| Ursu, D | 1 |
| Knopp, K | 1 |
| Beattie, RE | 1 |
| Liu, B | 1 |
| Sher, E | 1 |
| Rose, TE | 1 |
| Morisseau, C | 1 |
| Liu, JY | 1 |
| Inceoglu, B | 2 |
| Jones, PD | 1 |
| Sanborn, JR | 1 |
| Hammock, BD | 2 |
| Adedoyin, MO | 1 |
| Vicini, S | 1 |
| Rowbotham, MC | 1 |
| Nothaft, W | 2 |
| Duan, RW | 1 |
| Faltynek, C | 1 |
| McGaraughty, S | 1 |
| Chu, KL | 1 |
| Svensson, P | 1 |
| Liimatta, MB | 1 |
| Dudley, DT | 1 |
| Young, T | 1 |
| Wren, P | 1 |
| Blankman, JL | 1 |
| Nomura, DK | 1 |
| Bhattachar, SN | 1 |
| Nomanbhoy, TK | 1 |
| Hillery, CA | 1 |
| Kerstein, PC | 1 |
| Vilceanu, D | 1 |
| Barabas, ME | 1 |
| Retherford, D | 1 |
| Brandow, AM | 1 |
| Wandersee, NJ | 1 |
| Stucky, CL | 1 |
| Ho, YC | 1 |
| Lee, HJ | 1 |
| Tung, LW | 1 |
| Liao, YY | 1 |
| Fu, SY | 1 |
| Teng, SF | 1 |
| Liao, HT | 1 |
| Mackie, K | 1 |
| Chiou, LC | 1 |
| Sasso, O | 1 |
| Bertorelli, R | 1 |
| Bandiera, T | 1 |
| Scarpelli, R | 1 |
| Colombano, G | 1 |
| Armirotti, A | 1 |
| Moreno-Sanz, G | 1 |
| Reggiani, A | 1 |
| Piomelli, D | 1 |
| Mizobuchi, S | 1 |
| Matsuoka, Y | 1 |
| Obata, N | 1 |
| Kaku, R | 1 |
| Itano, Y | 1 |
| Tomotsuka, N | 1 |
| Taniguchi, A | 1 |
| Nishie, H | 1 |
| Kanzaki, H | 1 |
| Ouchida, M | 1 |
| Morita, K | 1 |
| Schaffler, K | 1 |
| Reeh, P | 1 |
| Duan, WR | 1 |
| Best, AE | 1 |
| Othman, AA | 1 |
| Locke, C | 1 |
| Nishimura, A | 1 |
| Kiyota, Y | 1 |
| Oki, H | 1 |
| Miyazaki, J | 1 |
| Igaki, S | 1 |
| Behnke, CA | 1 |
| WOOD, TJ | 1 |
| Hirasawa, S | 1 |
| Wroblewska, B | 1 |
| Grajkowska, E | 1 |
| Wroblewski, J | 1 |
| FORSTER, FM | 1 |
| FRANKEL, K | 1 |
| FAHRNI, R | 1 |
| Baraniuk, JN | 1 |
| Petrie, KN | 1 |
| Le, U | 1 |
| Tai, CF | 1 |
| Park, YJ | 1 |
| Yuta, A | 1 |
| Ali, M | 1 |
| Vandenbussche, CJ | 1 |
| Nelson, B | 1 |
| Högler, W | 1 |
| Yap, F | 1 |
| Little, D | 1 |
| Ambler, G | 1 |
| McQuade, M | 1 |
| Cowell, CT | 1 |
| Bayburt, EK | 4 |
| Schmidt, RG | 2 |
| Zheng, GZ | 1 |
| Perner, RJ | 2 |
| Didomenico, S | 2 |
| Koenig, JR | 2 |
| Turner, S | 1 |
| Jinkerson, T | 1 |
| Drizin, I | 2 |
| Hannick, SM | 2 |
| Macri, BS | 1 |
| McDonald, HA | 3 |
| Wismer, CT | 2 |
| Marsh, KC | 3 |
| Wetter, J | 1 |
| Stewart, KD | 1 |
| Oie, T | 1 |
| Ratnasooriya, WD | 1 |
| Deraniyagala, SA | 1 |
| Bathige, SD | 1 |
| Goonasekara, CL | 1 |
| Jayakody, JR | 1 |
| Mikusa, J | 3 |
| Zhu, CZ | 1 |
| El Kouhen, R | 1 |
| Aharon, I | 1 |
| Becerra, L | 1 |
| Becerraa, L | 1 |
| Chabris, CF | 1 |
| Borsook, D | 1 |
| Borsooka, D | 1 |
| Zheng, X | 1 |
| Hodgetts, KJ | 1 |
| Brielmann, H | 1 |
| Hutchison, A | 1 |
| Burkamp, F | 1 |
| Brian Jones, A | 1 |
| Blurton, P | 1 |
| Clarkson, R | 1 |
| Chandrasekhar, J | 1 |
| Bakthavatchalam, R | 1 |
| De Lombaert, S | 1 |
| Crandall, M | 1 |
| Cortright, D | 1 |
| Blum, CA | 1 |
| Schmelzer, KR | 1 |
| Kubala, L | 1 |
| Kim, IH | 1 |
| Jinks, SL | 1 |
| Eiserich, JP | 1 |
| Cui, M | 1 |
| Gauvin, D | 1 |
| Brown, B | 1 |
| Bianchi, B | 1 |
| McDonald, H | 1 |
| Niforatos, W | 1 |
| Neelands, TR | 1 |
| Moreland, RB | 1 |
| Decker, MW | 1 |
| Zhao, H | 1 |
| Sugawara, T | 1 |
| Miura, S | 1 |
| Iijima, T | 1 |
| Kashimoto, S | 1 |
| Ziebolz, D | 1 |
| Helms, K | 1 |
| Hannig, C | 1 |
| Attin, T | 1 |
| Keddy, R | 1 |
| Turner, SC | 1 |
| Jinkerson, TK | 1 |
| Wetter, JM | 2 |
| Grzegorzewska, AE | 1 |
| Młot-Michalska, M | 1 |
| Robertson, CE | 1 |
| Ford, MJ | 1 |
| Van Someren, V | 1 |
| Dlugolecka, M | 1 |
| Prescott, LF | 1 |
| Altieri, P | 1 |
| Sorba, GB | 1 |
| Bolasco, PG | 1 |
| Bostrom, M | 1 |
| Asproni, E | 1 |
| Ferrara, R | 1 |
| Bolasco, F | 1 |
| Cossu, M | 1 |
| Cadinu, F | 1 |
| Cabiddu, GF | 1 |
| Casu, D | 1 |
| Ganadu, M | 1 |
| Passaghe, M | 1 |
| Pinna, M | 1 |
| Greisen, J | 1 |
| Grøfte, T | 1 |
| Hansen, PO | 1 |
| Jensen, TS | 1 |
| Vilstrup, H | 1 |
| Urban, L | 1 |
| Campbell, EA | 1 |
| Panesar, M | 1 |
| Patel, S | 1 |
| Chaudhry, N | 1 |
| Kane, S | 1 |
| Buchheit, KH | 1 |
| Sandells, B | 1 |
| James, IF | 1 |
| Sakakibara, T | 1 |
| Hata, M | 1 |
| Numano, K | 1 |
| Kawase, Y | 1 |
| Yamanishi, T | 1 |
| Kawana, S | 1 |
| Tsuboi, N | 1 |
| Chamberlain, MA | 1 |
| Wright, V | 1 |
| Donnelly, AE | 2 |
| Maughan, RJ | 2 |
| Whiting, PH | 2 |
| McCormick, K | 1 |
| Clarkson, PM | 1 |
| Opio, E | 1 |
| Barnes, PM | 1 |
| Schwetlick, W | 1 |
| Mundorf, D | 1 |
| Horiuchi, H | 1 |
| Matthews, B | 1 |
| Huskisson, EC | 1 |
| Wojtulewski, JA | 1 |
| Berry, H | 1 |
| Scott, J | 1 |
| Hart, FD | 1 |
| Balme, HW | 1 |
| Guy, RB | 1 |
| Rothenberg, SP | 1 |
| Friedmann, I | 1 |
| Bauer, F | 1 |
| Scott, R | 1 |
| Barrie, W | 1 |
| Simpson, RW | 1 |
| Bell, D | 1 |
| Cummings, JH | 1 |
| Sladen, GE | 1 |
| James, OF | 1 |
| Sarner, M | 1 |
| Misiewicz, JJ | 1 |
| Brocks, BE | 1 |
| Pearson, HA | 1 |
| Diamond, LK | 1 |
| Lusher, JM | 1 |
| Barnhart, MI | 1 |
| Scott, RB | 1 |
| McCurdy, PR | 1 |
| Mahmood, L | 1 |
| Wickham, JE | 1 |
| Mathur, VK | 1 |
| Paalzow, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Study of the Safety, Tolerability and Pharmacokinetics of ABT-102 in Healthy Subjects[NCT00854659] | Phase 1 | 36 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| Comparison of the Effects of Instrumental Assisted Soft Tissue Mobilization and Foam Roller on Delayed Muscle Pain.[NCT05328830] | 42 participants (Actual) | Interventional | 2022-01-04 | Completed | |||
| Effect of a Cold Water Immersion (CWI) on Pain in People With Gouty Arthritis: A Community Based Randomized Controlled Trial[NCT04587544] | 76 participants (Actual) | Interventional | 2019-07-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for urea and Ache
| Article | Year |
|---|---|
Systematic Review of Thumb Carpometacarpal Joint Hemiresection Interposition Arthroplasty Materials.
Topics: Arthroplasty; Carpometacarpal Joints; Humans; Osteoarthritis; Pain; Polyurethanes; Thumb; Urea | 2022 |
Sickle cell crisis.
Topics: Abdomen, Acute; Abortion, Therapeutic; Acidosis; Anemia, Sickle Cell; Bicarbonates; Citrates; Dehydr | 1973 |
The critically ill child: sickle cell disease crises and their management.
Topics: Abdomen; Acidosis; Anemia, Sickle Cell; Bilirubin; Blood Cell Count; Blood Transfusion; Child; Chole | 1971 |
12 trials available for urea and Ache
| Article | Year |
|---|---|
Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial.
Topics: Abdomen; Administration, Cutaneous; Administration, Oral; Adolescent; Adult; Dose-Response Relations | 2011 |
An oral TRPV1 antagonist attenuates laser radiant-heat-evoked potentials and pain ratings from UV(B)-inflamed and normal skin.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Do | 2013 |
Efficacy and oral side effects of two highly concentrated tray-based bleaching systems.
Topics: Carbamide Peroxide; Colorimetry; Dentin Sensitivity; Drug Combinations; Gingivitis; Humans; Hydrogen | 2007 |
On-line predilution hemofiltration versus ultrapure high-flux hemodialysis: a multicenter prospective study in 23 patients. Sardinian Collaborative Study Group of On-Line Hemofiltration.
Topics: Aged; Arrhythmias, Cardiac; beta 2-Microglobulin; Bicarbonates; Body Weight; Electrolytes; Fatigue; | 1997 |
A double blind trial to assess the value of alclofenac compared with phenylbutazone in the management of rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Eruptions; Female; Ga | 1975 |
Effects of ibuprofen on exercise-induced muscle soreness and indices of muscle damage.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Creatine Kinase; Creatinine; Humans; Ibuprofen; L-La | 1990 |
Effects of a non-steroidal anti-inflammatory drug on delayed onset muscle soreness and indices of damage.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Creatine Kinase; Creatinine; Diclofenac; Double-Blin | 1988 |
Intravenous urea in treatment of bone-pain crises of sickle-cell disease. A double-blind trial.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Blood Urea Nitrogen; Bone Diseases; Child; Clinical Trials a | 1972 |
Clinical trials of therapy for sickle cell vaso-occlusive crises. Cooperative urea trials group.
Topics: Alkalies; Anemia, Sickle Cell; Arterial Occlusive Diseases; Bicarbonates; Blood Urea Nitrogen; Evalu | 1974 |
Treatment of rheumatoid arthritis with fenoprofen: comparison with aspirin.
Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Body Temperature; Clinical Trials as Topic; Deafness; | 1974 |
Treatment of sickle cell crisis with urea in invert sugar. A controlled trial. Cooperative urea trials group.
Topics: Adult; Age Factors; Anemia, Sickle Cell; Blood Urea Nitrogen; Body Weight; Child; Clinical Trials as | 1974 |
A comparison of flufenamic acid and phenylbutazone in osteoarthritis of the hip.
Topics: Aged; Anti-Inflammatory Agents; Aspirin; Blood Sedimentation; Body Weight; Clinical Trials as Topic; | 1966 |
77 other studies available for urea and Ache
| Article | Year |
|---|---|
Orexin receptors in the CA1 region of hippocampus modulate the stress-induced antinociceptive responses in an animal model of persistent inflammatory pain.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzoxazoles; CA1 Region, Hippocampal; Cycl | 2022 |
Synthesis and biological evaluation of new series of benzamide derivatives containing urea moiety as sEH inhibitors.
Topics: Animals; Benzamides; Enzyme Inhibitors; Epoxide Hydrolases; Pain; Rats; Structure-Activity Relations | 2022 |
Discovery of benzamide derivatives containing urea moiety as soluble epoxide hydrolase inhibitors.
Topics: Animals; Benzamides; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Molecular Docking Simulation; Pa | 2022 |
Discovery of pyridyl urea sulfonamide inhibitors of Na
Topics: Humans; NAV1.7 Voltage-Gated Sodium Channel; Pain; Quinolones; Structure-Activity Relationship; Sulf | 2022 |
Development of indole-2-carbonyl piperazine urea derivatives as selective FAAH inhibitors for efficient treatment of depression and pain.
Topics: Amidohydrolases; Animals; Depression; Endocannabinoids; Enzyme Inhibitors; Heterocyclic Compounds; H | 2022 |
Treatment of Insertional Achilles Tendinosis With Polyurethane Urea-Based Matrix Augmentation.
Topics: Achilles Tendon; Humans; Middle Aged; Pain; Polyurethanes; Retrospective Studies; Tendinopathy; Trea | 2023 |
Efficacy and tolerability of a repairing moisturizing cream containing amino-inositole and urea 10% in adults with chronic eczematous dermatitis of the hands.
Topics: Adult; Eczema; Emollients; Humans; Immunoglobulin A; Pain; Pruritus; Treatment Outcome; Urea | 2023 |
Molecular Dynamics Simulations to Investigate How PZM21 Affects the Conformational State of the μ-Opioid Receptor Upon Activation.
Topics: Analgesia; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; GTP-Binding Proteins; Huma | 2020 |
Soluble epoxide hydrolase inhibitor trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)urea prevents hyperalgesia through regulating NLRC4 inflammasome-related pro-inflammatory and anti-inflammatory signaling pathways in the lipopolysaccharide-induced pa
Topics: Animals; Anti-Inflammatory Agents; Epoxide Hydrolases; Hyperalgesia; Inflammasomes; Intercellular Si | 2021 |
Novel piperazine urea derivatives as highly potent transient receptor potential vanilloid 1 (TRPV1) antagonists.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Humans; Male; Molecular Structure; | 2021 |
A role for the locus coeruleus in the analgesic efficacy of N-acetylaspartylglutamate peptidase (GCPII) inhibitors ZJ43 and 2-PMPA.
Topics: Analgesics; Animals; Disease Models, Animal; Dopamine beta-Hydroxylase; Excitatory Amino Acid Agents | 2017 |
Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo.
Topics: Animals; Anti-Inflammatory Agents; Behavior, Animal; Disease Models, Animal; Enzyme Inhibitors; Huma | 2018 |
Antinociceptive activity of Riparin II from Aniba riparia: Further elucidation of the possible mechanisms.
Topics: Acid Sensing Ion Channels; Alanine Transaminase; Analgesics; Animals; Aspartate Aminotransferases; B | 2018 |
Effects of intrathecal administration of orexin-1 receptor antagonist on antinociceptive responses induced by chemical stimulation of lateral hypothalamus in an animal model of tonic nociception.
Topics: Analgesics; Animals; Benzoxazoles; Hypothalamic Area, Lateral; Injections, Spinal; Male; Naphthyridi | 2018 |
Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors.
Topics: Administration, Oral; Amidohydrolases; Analgesics; Animals; Brain; Disease Models, Animal; Drug Desi | 2014 |
Synthesis and biological evaluation of N-dehydrodipeptidyl-N,N'-dicyclohexylurea analogs.
Topics: Acetic Acid; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; An | 2014 |
Eutectic, monotectic and immiscibility systems of nimesulide with water-soluble carriers: phase equilibria, solid-state characterisation and in-vivo/pharmacodynamic evaluation.
Topics: Acetic Acid; Animals; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Cyclooxygenase | 2014 |
Synthesis of carbamide derivatives bearing tetrahydroisoquinoline moieties and biological evaluation as analgesia drugs in mice.
Topics: Analgesics; Animals; Behavior, Animal; Cells, Cultured; Disease Models, Animal; Dose-Response Relati | 2015 |
Microinjection of orexin-A into the rat locus coeruleus nucleus induces analgesia via cannabinoid type-1 receptors.
Topics: Analgesics; Analysis of Variance; Animals; Benzoxazoles; Carrier Proteins; Dose-Response Relationshi | 2015 |
Differential contribution of orexin receptors within the ventral tegmental area to modulation of persistent inflammatory pain.
Topics: Animals; Benzoxazoles; Carbachol; Hypothalamic Area, Lateral; Isoquinolines; Male; Naphthyridines; N | 2016 |
Functional interaction between orexin-1 and CB1 receptors in the periaqueductal gray matter during antinociception induced by chemical stimulation of the lateral hypothalamus in rats.
Topics: Animals; Benzoxazoles; Carbachol; Disease Models, Animal; Hypothalamic Area, Lateral; Male; Microinj | 2016 |
Blood parameters and electroencephalographic responses of goats to slaughter without stunning.
Topics: Abattoirs; Anesthesia; Animal Welfare; Animals; Blood Glucose; Calcium; Catecholamines; Consciousnes | 2016 |
Structure-based discovery of opioid analgesics with reduced side effects.
Topics: Analgesia; Analgesics, Opioid; Animals; Drug Discovery; GTP-Binding Protein alpha Subunits, Gi-Go; H | 2016 |
Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain.
Topics: Analgesics; Animals; Dipeptides; Glutamate Carboxypeptidase II; Inflammation Mediators; Injections, | 2008 |
Orexin affects dorsal root ganglion neurons: a mechanism for regulating the spinal nociceptive processing.
Topics: Action Potentials; Animals; Benzoxazoles; Calcium Signaling; Ganglia, Spinal; Intracellular Signalin | 2008 |
Additive antinociceptive effects of the selective Nav1.8 blocker A-803467 and selective TRPV1 antagonists in rat inflammatory and neuropathic pain models.
Topics: Analgesics; Aniline Compounds; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fr | 2009 |
Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia.
Topics: Analgesics; Animals; Body Temperature; Bone Neoplasms; Calcium; Disease Models, Animal; Drug Interac | 2009 |
Capsaicin receptor antagonists: a promising new addition to the pain clinic.
Topics: Analgesics; Anilides; Cinnamates; Humans; Pain; Pain Clinics; Pyrrolidines; TRPV Cation Channels; Ur | 2009 |
Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Brain; Crystallography, X-Ray; Endocannabinoids; Enzyme | 2009 |
The role of spinal orexin-1 receptors in posterior hypothalamic modulation of neuropathic pain.
Topics: Analgesics; Animals; Benzoxazoles; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug | 2009 |
Orexins activates protein kinase C-mediated Ca(2+) signaling in isolated rat primary sensory neurons.
Topics: Animals; Benzoxazoles; Calcium Signaling; Cells, Cultured; Ganglia, Spinal; Intracellular Signaling | 2010 |
Effect of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles on chronic inflammatory pain model in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Body Weight; Chronic Disease | 2009 |
Do you feel my pain? Racial group membership modulates empathic neural responses.
Topics: Adult; Analysis of Variance; Brain Mapping; Carbamide Peroxide; Cerebral Cortex; Drug Combinations; | 2009 |
The effects of the TRPV1 receptor antagonist SB-705498 on trigeminovascular sensitisation and neurotransmission.
Topics: Analgesics; Animals; Blood Pressure; Cats; Cerebrovascular Circulation; Disease Models, Animal; Dura | 2009 |
Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues.
Topics: Amides; Animals; Anticonvulsants; Electroshock; Isomerism; Male; Mice; Pain; Pentylenetetrazole; Rat | 2009 |
Thermal nociception is decreased by hypocretin-1 and an adenosine A1 receptor agonist microinjected into the pontine reticular formation of Sprague Dawley rat.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Aging; Animals; Benzoxazoles; Hot Temperature; Intracellu | 2010 |
Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath.
Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cold Temperature; Disease Models, Ani | 2010 |
Pungency of TRPV1 agonists is directly correlated with kinetics of receptor activation and lipophilicity.
Topics: Action Potentials; Alkaloids; Animals; Benzodioxoles; Capsaicin; Diterpenes; Ganglia, Spinal; Kineti | 2010 |
1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain.
Topics: Adamantane; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Epoxi | 2010 |
Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model.
Topics: Amygdala; Animals; Behavior, Animal; Dipeptides; Disease Models, Animal; Excitatory Postsynaptic Pot | 2010 |
Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.
Topics: Amidohydrolases; Animals; Enzyme Inhibitors; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; P | 2011 |
Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease.
Topics: Action Potentials; Anemia, Sickle Cell; Animals; Capsaicin; Disease Models, Animal; Female; Humans; | 2011 |
Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition.
Topics: Analysis of Variance; Animals; Animals, Newborn; Arachidonic Acids; Benzoxazines; Benzoxazoles; Biph | 2011 |
Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.
Topics: Amidohydrolases; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experiment | 2012 |
Antinociceptive effects of intrathecal landiolol injection in a rat formalin pain model.
Topics: Analgesics; Animals; Disease Models, Animal; Formaldehyde; Injections, Spinal; Male; Morpholines; Pa | 2012 |
Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.
Topics: Amidohydrolases; Analgesics; Animals; Humans; Mice; Molecular Docking Simulation; Pain; Piperazine; | 2013 |
EXPERIENCES WITH PERITONEAL DIALYSIS.
Topics: Bicarbonates; Dialysis; Drainage; Equipment and Supplies; Fluid Therapy; Hemoperitoneum; Humans; Kid | 1965 |
Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model.
Topics: Amino Acids; Analgesics; Animals; Behavior, Animal; Cell Line; Disease Models, Animal; Dose-Response | 2004 |
Insensitivity to pain as a complication of phenurone therapy in epilepsy.
Topics: Benzeneacetamides; Epilepsy; Pain; Urea | 1950 |
[Toxic psychoses due to sedormid, saridon and contra-pain].
Topics: Analgesics; Antipyrine; Caffeine; Drug Combinations; Humans; Hypnotics and Sedatives; Pain; Phenacet | 1950 |
Neuropathology in rhinosinusitis.
Topics: Acute Disease; Administration, Intranasal; Adult; Albumins; Dose-Response Relationship, Drug; Fatigu | 2005 |
Short-term safety assessment in the use of intravenous zoledronic acid in children.
Topics: Adolescent; Bone Resorption; Calcium; Child; Child, Preschool; Creatinine; Diphosphonates; Female; F | 2004 |
Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.
Topics: Abdominal Pain; Administration, Oral; Analgesics; Animals; Biological Availability; Calcium; Cells, | 2005 |
Antinociceptive action of aqueous extract of the leaves of Ixora coccinea.
Topics: Alanine Transaminase; Analgesics; Animals; Antioxidants; Aspartate Aminotransferases; Cell Membrane; | 2005 |
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats.
Topics: Acute Disease; Analgesics; Animals; Capsaicin; Carrageenan; Chronic Disease; Dose-Response Relations | 2005 |
Noxious heat induces fMRI activation in two anatomically distinct clusters within the nucleus accumbens.
Topics: Adult; Brain Mapping; Carbamide Peroxide; Cluster Analysis; Drug Combinations; Functional Laterality | 2006 |
From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist.
Topics: Administration, Oral; Amides; Analgesics, Non-Narcotic; Animals; Biological Availability; Humans; Mo | 2006 |
Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors.
Topics: Adamantane; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Di | 2006 |
TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists.
Topics: Administration, Oral; Analgesics; Animals; Arthralgia; Calcium; Capsaicin; Cell Line; Cells, Culture | 2006 |
Intrathecal landiolol inhibits nociception and spinal c-Fos expression in the mouse formalin test.
Topics: Adrenergic beta-Antagonists; Anesthesia, Spinal; Animals; Formaldehyde; Injections, Spinal; Male; Mi | 2007 |
Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model.
Topics: Analgesics; Animals; Inflammation; Methylation; Models, Biological; Pain; Rats; TRPV Cation Channels | 2007 |
Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management.
Topics: Administration, Oral; Analgesics; Animals; Biological Availability; Dogs; Haplorhini; Humans; In Vit | 2008 |
Bone pain in dialysis patients is not associated with bone mineral density but with serum concentration of small uremic toxins.
Topics: Adult; Aged; Bone and Bones; Bone Density; Female; Humans; Kidney Diseases; Male; Middle Aged; Multi | 2007 |
Mefenamic acid nephropathy.
Topics: Aged; Creatinine; Female; Humans; Kidney Concentrating Ability; Kidney Failure, Chronic; Mefenamic A | 1980 |
Acute non-traumatic pain increases the hepatic amino- to urea-N conversion in normal man.
Topics: Acute Disease; Adult; Amino Acids; Anesthetics, Local; Cross-Over Studies; Electric Stimulation; Epi | 1999 |
In vivo pharmacology of SDZ 249-665, a novel, non-pungent capsaicin analogue.
Topics: Analgesics; Animals; Behavior, Animal; Blinking; Blood Pressure; Bronchoconstriction; Capsaicin; Car | 2000 |
Fixed-drug eruption caused by allylisopropylacetylurea.
Topics: Adult; Diagnosis, Differential; Drug Eruptions; Female; Herpes Genitalis; Humans; Hypnotics and Seda | 2001 |
[On pain and fever treatment in pediatric orthopedics].
Topics: Analgesics; Butyrates; Child; Child, Preschool; Dosage Forms; Drug Synergism; Female; Fever; Humans; | 1967 |
In-vitro observations on fluid flow through human dentine caused by pain-producing stimuli.
Topics: Ammonium Chloride; Calcium Chloride; Dental Pulp; Dentin; Dentin Sensitivity; Electrophysiology; Hot | 1973 |
Wegener's granulomatosis causing deafness.
Topics: Adult; Blood Transfusion; Conjunctivitis; Deafness; Diarrhea; Dyspnea; Ear; Edema; Eosinophils; Face | 1973 |
The use of pentazocine as a strong analgesic in urological practice.
Topics: Adult; Analgesics; Body Weight; Female; Humans; Injections, Intramuscular; Male; Meperidine; Middle | 1973 |
Laxative-induced diarrhoea: a continuing clinical problem.
Topics: Abdomen; Adult; Aged; Bicarbonates; Body Weight; Cathartics; Colon; Diarrhea; Feces; Female; Humans; | 1974 |
Evaluation of oral urea in the management of sickle cell anemia.
Topics: Administration, Oral; Anemia, Sickle Cell; Blood Platelets; Blood Urea Nitrogen; Erythrocytes; Hemat | 1972 |
Urea therapy in sickle-cell anemia.
Topics: Anemia, Sickle Cell; Cyanates; Heme; Hemolysis; Humans; Pain; Urea | 1971 |
Intravenous urea treatment of the painful crisis of sickle-cell disease. A preliminary report.
Topics: Adult; Anemia, Sickle Cell; Blood Urea Nitrogen; Diuresis; Hemoglobinopathies; Humans; Injections, I | 1971 |
Hypothermia in the conservative surgery of renal disease.
Topics: Blood Transfusion; Child; Child, Preschool; Female; Humans; Hypothermia, Induced; Kidney Calculi; Ki | 1971 |
Studies of analgesic and anticonvulsant activity in mice by high-frequency electrical stimulation.
Topics: Age Factors; Analgesics; Animals; Anticonvulsants; Aspirin; Body Weight; Electric Stimulation; Elect | 1969 |