thymosin and Precancerous-Conditions
thymosin has been researched along with Precancerous-Conditions* in 3 studies
Reviews
1 review(s) available for thymosin and Precancerous-Conditions
Article | Year |
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[Thymosin and tumors].
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Humans; Immunologic Factors; Precancerous Conditions; Stomach Neoplasms; Thymosin | 2001 |
Other Studies
2 other study(ies) available for thymosin and Precancerous-Conditions
Article | Year |
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Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice.
The emergence of oxyntic atrophy and metaplastic cell lineages in response to chronic Helicobacter pylori infection predisposes to gastric neoplasia. We have described a trefoil factor family 2 (TFF2; spasmolytic polypeptide) expressing metaplasia (SPEM) associated with gastric neoplasia in both rodent and human fundus. To examine the relationship of SPEM to the neoplastic process in the H. felis -infected C57BL/6 mouse, we have now studied the association of SPEM-related transcripts with preneoplasia.. SPEM-related transcripts were identified by microarray analysis of amplified cRNA from SPEM, and surface mucous cells were isolated by laser capture microdissection from the same gastric sections from male C57BL/6 mice infected with H. felis for 6 months. Expression of SPEM-related transcripts was assessed by in situ hybridization and quantitative RT-PCR, as well as immunohistochemistry for prothymosin alpha.. Eleven SPEM-related transcripts were identified as detectable only in SPEM. The expression of the SPEM-related transcripts was validated by in situ hybridization and quantitative PCR. One transcript, the noncoding RNA Xist, was only identified in SPEM cells from the infected male mice. Ten of the 11 transcripts as well as TFF2 were also expressed in regions of gastritis cystica profunda. Immunocytochemistry for one of the identified proteins, prothymosin alpha, demonstrated prominent nuclear staining in SPEM and gastritis cystica profunda.. The expression of SPEM-related transcripts in regions of gastritis cystica profunda suggests that SPEM represents a precursor lineage for the development of dysplasia in this animal model of gastric carcinogenesis. Topics: Animals; Helicobacter felis; Helicobacter Infections; Immunohistochemistry; In Situ Hybridization; Intercellular Signaling Peptides and Proteins; Male; Metaplasia; Mice; Mice, Inbred C57BL; Mucins; Muscle Proteins; Neuropeptides; Oligonucleotide Array Sequence Analysis; Peptides; Polymerase Chain Reaction; Precancerous Conditions; Protein Precursors; RNA, Messenger; Stomach Neoplasms; Thymosin; Trefoil Factor-2; Trefoil Factor-3 | 2004 |
Reduction in responsiveness of thymocytes to phytohemagglutinin during bladder tumor induction and restorative effects of thymosin fraction 5 in rats.
Urinary bladder tumors were induced in female Wistar rats by oral administration of N-butyl-N-(4-hydroxybutyl) nitrosamine [(BBN) CAS: 3817-11-6]. Hypertrophy or vascular formation was observed in the bladder membrane 8 weeks after BBN administration, and tumors became visible at the 15th week. At the 20th week, approximately 95% of these rats had bladder tumors. The response of thymus lymphocytes to phytohemagglutinin (PHA) in these BBN-treated rats began to decrease from the 10th week and decreased significantly from the 18th week as compared with that in untreated rats. This reduced response to PHA was slower in comparison with the reduced response to concanavalin A. When thymus lymphocytes were preincubated with thymosin fraction 5 in vitro, the response to PHA improved between the 8th week and the 20th week. Furthermore, when the thymus small lymphocyte population was separated into 3 subpopulations by discontinuous density gradient centrifugation and adhesion column, the restorative effect of the thymus hormonal product was greater in the intermediate and heavier subpopulations. Topics: Animals; Butylhydroxybutylnitrosamine; Female; Lymphocyte Activation; Phytohemagglutinins; Precancerous Conditions; Rats; Rats, Inbred Strains; T-Lymphocytes; Thymosin; Thymus Gland; Time Factors; Urinary Bladder Neoplasms | 1987 |