thiophenes has been researched along with Ache in 184 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (8.70) | 18.7374 |
| 1990's | 8 (4.35) | 18.2507 |
| 2000's | 77 (41.85) | 29.6817 |
| 2010's | 75 (40.76) | 24.3611 |
| 2020's | 8 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, F; Li, B; Li, T; Wang, D; Wang, L; Wang, T; Zhang, L | 1 |
| Chai, XQ; Gao, W; Hu, SS; Long, DD; Pan, TT; Shen, L; Wang, D | 1 |
| Baroncini, A; Bell, A; Colarossi, G; Eschweiler, J; Maffulli, N; Migliorini, F | 1 |
| Bruno, V; Farcy, N; Karnik, V; Zamorano, C | 1 |
| Huang, T; Li, J; Zhao, Z | 1 |
| Calo, G; Lambert, D | 1 |
| Banks, ML; Blough, BE; Bohn, LM; Cornelissen, JC; Negus, SS | 1 |
| Abreu, SC; Alves, SM; Bezerra, MM; Chaves, HV; Cristino-Filho, G; de Castro Brito, GA; de Paulo Teixeira Pinto, V; do Val, DR; Freitas, RS; Gomes, FIF; Lemos, JC; Pereira, KMA | 1 |
| Wadman, M | 1 |
| Burt, DA; Farrell, C; Fossler, MJ; Pitsiu, M; Sadler, BM; Skobieranda, F; Soergel, DG | 2 |
| Abbruzzese, G; Antonini, A; Berardelli, A; Chaudhuri, KR; Defazio, G; Ferreira, J; Martinez-Martin, P; Rascol, O; Tinazzi, M; Trenkwalder, C | 1 |
| Austin Zamarripa, C; Blough, BE; Edwards, SR; Freeman, KB; Qureshi, HN; Yi, JN | 1 |
| Charipova, K; Gress, K; Kaye, AD; Ngo, A; Orhurhu, V; Urits, I; Viswanath, O | 1 |
| Ataga, KI; Frelinger, AL; Heath, LE; Jakubowski, JA; Knupp, CL; Krishnamurti, L; Kutlar, A; McMahon, LE; Novelli, EM; Nwachuku, CE; Riesmeyer, JS; Soulieres, D; Strouse, JJ; Winters, KJ; Wun, T; Zhou, C | 1 |
| Balbaba, M; Çelebi, S; Ulaş, F | 1 |
| D'Souza, DN; Frakes, EP; Gaynor, PJ; Hochberg, MC; Risser, RC | 1 |
| Alba-Alcántara, L; Bermejo, PE; Ruiz-Huete, C; Zea, MA | 1 |
| Durakoğlugil, ME; Kaplan, C; Kaya, E; Kocaman, SA; Senol, MG | 1 |
| Ahl, J; Micca, JL; Ruff, D; Wohlreich, MM | 1 |
| Ahl, J; Frakes, E; Risser, RC; Wohlreich, M | 1 |
| Bouhassira, D; Cruccu, G; Freynhagen, R; Lledo, A; Schacht, A; Skljarevski, V; Tesfaye, S; Tölle, T; Wilhelm, S | 1 |
| Finnerup, NB | 1 |
| Gaynor, PJ; Lipsius, S; Marangell, LB; Namiki, C; Ohara, F; Robinson, MJ; Sheehan, D; Tanaka, Y | 1 |
| DU, XN; Huang, F; Huang, ZF; Li, Y; Zhang, SL; Zhu, J | 1 |
| Boulton, AJ; Dickenson, AH; Tesfaye, S | 1 |
| Cui, JH; Ju, J; Yoon, MH | 1 |
| Malcolm, SK; Risser, RC; Robinson, MJ; Vollmer, TL | 1 |
| Scheinfeld, N | 1 |
| Liu, P; Nelson, JC; Oakes, TM; Raskin, J; Robinson, M; Shoemaker, S | 1 |
| Benoliel, R; Haviv, Y; Sharav, Y; Zadik, Y | 1 |
| Authier, N; Balayssac, D; Eschalier, A; Ferrier, J; Ling, B; Pereira, B | 1 |
| Boroojerdi, B; Chaudhuri, KR; Ghys, L; Kassubek, J; Moran, K; Surmann, E; Trenkwalder, C; Zesiewicz, T | 1 |
| Aarons, L; Gueorguieva, I; Yuen, E | 1 |
| Ishikawa, G; Nagakura, Y; Shimizu, Y; Takeshita, N | 1 |
| Burnham, N; James, IE; Lark, MW; Sadler, BM; Skobieranda, F; Soergel, DG; Subach, RA; Violin, JD; Webster, LR | 1 |
| Berggren, L; Gilaberte, I; Lenox-Smith, A; Pérez, V; Quail, D; Romera, I | 1 |
| Abraham, S; Hayes, ES; Pugsley, MK; Saint, DA; Walker, MJ | 1 |
| Ding, C; Hunter, DJ; Wang, K; Xu, J | 1 |
| Aryal, DK; Bernat, V; Corder, G; Dengler, D; Giguère, PM; Gmeiner, P; Huang, XP; Hübner, H; Kling, RC; Kobilka, BK; Levit, A; Lin, H; Löber, S; Manglik, A; McCorvy, JD; Roth, BL; Sassano, MF; Scherrer, G; Shoichet, BK | 1 |
| Bauer, L; Fröhlich, H; Kassubek, J; Lauterbach, T; Oehlwein, C; Ransmayr, G; Schroeder, H; Timmermann, L; Will, E | 1 |
| Asiedu, MN; Dib-Hajj, SD; Dussor, G; Han, C; Price, TJ; Waxman, SG | 1 |
| Brecht, S; Chen, A; Fava, M; Perahia, D; Walker, D; Wiltse, C | 1 |
| Mallinckrodt, CH; Meyers, AL; Prakash, A; Robinson, MJ; Russell, JM; Sheehan, DV; Swindle, RW | 1 |
| Forde, G; Stanos, S | 1 |
| Derry, S; Gaskell, H; Moore, RA; Sultan, A | 1 |
| Griffith, JM; Hasley, JP; Severn, DG | 1 |
| Desaiah, D; Montejo, AL; Perahia, DG; Quail, D; Schatzberg, AF | 1 |
| Diaz, JL; Holenz, J; Oberdorf, C; Schepmann, D; Vela, JM; Wünsch, B | 1 |
| Eisenach, JC; Hayashida, K | 1 |
| Chappell, AS; Detke, MJ; Fishbain, DA; Kajdasz, DK; Wernicke, J | 1 |
| Bentley, S; Fan, MY; Gardner, G; Sullivan, MD | 1 |
| de Tommaso, M; Ranieri, M; Sardaro, M; Serpino, C; Stasi, M; Vecchio, E | 1 |
| Voznesenskaia, TG | 1 |
| Chappell, AS; Detke, MJ; Kajdasz, DK; Mease, PJ; Russell, IJ; Walker, DJ; Wiltse, CG; Wohlreich, MM | 1 |
| Chancellor, J; Garcia-Cebrian, A; Le, TK; Löthgren, M; Monz, B; Quilici, S; Said, G; Simon, D | 1 |
| Ememlin, AIu; Kashin, AV; Odinak, MM | 1 |
| Alda, M; Andrés, E; del Hoyo, YL; García-Campayo, J; Luciano, JV; Magallón, R; Rodero, B; Serrano-Blanco, A | 1 |
| Chappell, AS; D'Souza, DN; Kajdasz, DK; Littlejohn, G; Moldofsky, H; Scheinberg, M | 1 |
| Apostolaki, S; Arvaniti, C; Chatzimichael, K; Kitsiou, MC; Kostopanagiotou, G; Matsota, P | 1 |
| Bennett, RM; Chappell, AS; Collins, H; Iyengar, S; Li, LC; Liu-Seifert, H; Ossanna, MJ; Skljarevski, V | 1 |
| Ball, S; Beesdo, K; Hartford, J; Russell, J; Spann, M; Wittchen, HU | 1 |
| Cummons, TA; Harrison, JE; Leventhal, L; Lu, P; Piesla, MJ; Strassle, BW; Whiteside, GT | 1 |
| Baker, SJ; Boyce-Rustay, JM; Decker, MW; Honore, P; Kohnken, R; Simler, GH; Wensink, EJ; Zhong, C | 1 |
| Ahl, J; Arnold, LM; Bradley, LA; Choy, EH; Hudson, JI; Mease, PJ; Wang, F; Wohlreich, MM | 1 |
| Aliaga, M; Bardin, L; Depoortère, R; Gregoire, S; Ladure, P; Malfetes, N; Newman-Tancredi, A; Vitton, O | 1 |
| Chou, YH; Li, CT; Su, TP | 1 |
| Staud, R | 1 |
| Ameri, AA | 2 |
| Blouin, M; Burch, J; Clark, P; Denis, D; Ducharme, Y; Farand, J; Friesen, R; Gaudreault, M; Han, Y; Lévesque, JF; Mathieu, MC; Mellon, C; O'Neill, G; Rowland, S; Stocco, R; Therien, A; Vigneault, E; Wrona, M; Xu, D | 1 |
| Bitter, I; Karamustafalioglu, O; Koponen, H; Mohr, P; Sartorius, N; Seifritz, E; Svestka, J | 1 |
| Dyhr, H; Grunnet, M; Munro, G | 1 |
| Bradley, L; Choy, E; Clauw, DJ; Marangell, LB; Mease, P; Shoemaker, S; Wang, F; Wohlreich, MM | 1 |
| Hettinger, K; Lindsay, TJ; Rodgers, BC; Savath, V | 1 |
| Cardoner, N; Contreras-Rodríguez, O; Deus, J; Harrison, BJ; Hernández-Ribas, R; López-Solà, M; Menchón, JM; Ortiz, H; Pujol, J; Soriano-Mas, C; Vallejo, J | 1 |
| Jones, KD; Mist, SD; Ross, RL; Wright, CL | 1 |
| Cao, Z; Fowler, R; Harnett, J; Mardekian, J; Margolis, J; Sanchez, RJ; Silverman, SL | 1 |
| Spingler, A | 1 |
| Spielmans, GI | 2 |
| Bär, KJ; Berger, S; Boettger, MK; Boettger, S; Terhaar, J; Weiss, T | 1 |
| Arnold, LM; Bradley, LA; Chappell, AS; Clauw, DJ; Kajdasz, DK; Mease, PJ; Russell, IJ; Spaeth, M; Walker, DJ | 1 |
| Duenas, H; Gaynor, P; McCarberg, B; Shoemaker, S; Zheng, W | 1 |
| Marcus, DA | 1 |
| Liu, X; Mullins, CD; Wang, J | 1 |
| Boulanger, L; Chen, S; Fraser, K; Wu, N; Zhao, Y; Zhao, Z | 1 |
| Chokka, PR; Granger, RE; Raskin, J; Sagman, D; Sheehan, DV; Walton, RJ | 1 |
| Banerjee, M; Griggs, JJ; Hayes, DF; Henry, NL; Schott, AF; Smerage, JB; Van Poznak, C; Wicha, M | 1 |
| Arnold, LM; Gaynor, PJ; Heinloth, AN; Ruberg, SJ; Wang, F | 1 |
| Gaynor, PJ; Gopal, M; Hann, D; Marangell, LB; Martinez, JM; Robinson, MJ; Zheng, W | 1 |
| Gaynor, PJ; Gopal, M; Marangell, LB; Martinez, JM; Robinson, MJ; Zheng, W | 1 |
| Bernauer, MJ; Boulanger, L; Chen, SY; Fraser, K; Nagar, S; Wu, N; Zhao, Y; Zhao, Z | 1 |
| Andrews, JS; Annedi, SC; Bunton, D; Christie, L; Lee, DK; Maddaford, SP; Mladenova, G; Porreca, F; Rakhit, S; Ramnauth, J; Zhang, D | 1 |
| Hegerl, U; Hundemer, HP; Linden, M; Quail, D; Schneider, E; Wagner, T; Weigmann, H | 1 |
| Emel'ianov, VV; Galkin, VV; Nesterova, MV | 1 |
| Ball, TD; Frakes, EP; Hochberg, MC; Risser, RC; Wohlreich, MM | 1 |
| Brecht, S; Croenlein, J; Demyttenaere, K; Desaiah, D; Petit, C | 1 |
| Dyhr, H; Erichsen, HK; Hansen, MK; Marcher, L; Munro, G; Sheykhzade, M; Storm, A | 1 |
| Boess, FG; Hegerl, U; Linden, M; Mergl, R; Schacht, A; Schneider, E; Wilhelm, S | 1 |
| Abbar, M; Gilaberte, I; Menchón, JM; Neuhauser, D; Papen, R; Pérez, V; Picard, H; Romera, I; Schacht, A | 1 |
| Boyle, J; Coppini, DV; Eriksson, ME; Gouni, R; Gribble, L; Johnsen, S; Kerr, D | 1 |
| Ahl, J; Fijal, BA; Houston, JP; Kohler, J; Ostbye, K | 1 |
| Fishbain, DA | 2 |
| Briley, M | 2 |
| Leech, JN; Stewart, JA; Stewart, WC | 1 |
| Stewart, DE | 1 |
| Schatzberg, AF | 1 |
| Leo, RJ | 1 |
| Bailey, KP | 1 |
| Day, DG; Holmes, KT; Jenkins, JN; Stewart, JA; Stewart, WC | 1 |
| Bantel, C; Childers, SR; Conklin, D; Eisenach, JC; Li, X | 1 |
| Detke, MJ; Fava, M; Mallinckrodt, CH; Watkin, JG; Wohlreich, MM | 1 |
| Hemrick-Luecke, SK; Iyengar, S; Simmons, RM; Webster, AA; Xu, JY | 1 |
| Gonzales, JS; Watkin, JG; Wohlreich, MM | 1 |
| Delgado, PL | 1 |
| Jones, CK; Peters, SC; Shannon, HE | 2 |
| Brannan, SK; Brown, EB; Mallinckrodt, CH; Schatzberg, AF; Watkin, JG; Wohlreich, MM | 1 |
| Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD | 1 |
| Detke, MJ; Kennedy, JS; Mallinckrodt, CH; Nelson, JC; Watkin, JG; Wohlreich, MM | 1 |
| Araldi, D; Goncales, CE; Nogueira, CW; Panatieri, RB; Rocha, JB; Zeni, G | 1 |
| Konarski, JZ; McIntyre, RS | 1 |
| Bauer, M; Möller, HJ; Schneider, E | 1 |
| Das, A; Desarkar, P; Sinha, VK | 1 |
| Russell, JW | 1 |
| Desaiah, D; Perahia, DG; Pritchett, YL; Raskin, J | 1 |
| D'Souza, DN; Iyengar, S; Pritchett, YL; Raskin, J; Tran, P; Waninger, A; Wernicke, JF | 1 |
| O'Connor, AB | 1 |
| Hajak, G | 1 |
| Ziegler, D | 1 |
| Meighen, KG | 1 |
| Ari, S; Caça, I; Keklikçi, U; Simsek, H; Unlü, K | 1 |
| Terneus, W | 1 |
| Colman, SA; Harrison, GA; Hong, JP; Lee, MS; Lee, P; Liu, CY; Raskin, J; Ruschel, S; Shu, L; Wang, CY; Xu, X | 1 |
| Wallace, JM | 1 |
| Dinkel, JJ; Mohs, RC; Raskin, J; Rotz, BT; Sheikh, J; Siegal, A; Wiltse, CG; Xu, J | 1 |
| Leventhal, L; Piesla, M; Wantuch, C | 1 |
| D'Souza, DN; Erickson, JS; Fava, M; Hartford, JT; Russell, JM; Weisberg, R | 1 |
| Iosifescu, DV; Raskin, J; Sheridan, M; Wiltse, CG; Wise, TN; Xu, JY | 1 |
| Cohen, LS; Joffe, H; Koch, JK; Petrillo, LF; Soares, CN; Somley, BL; Viguera, AC | 1 |
| Ansell, L; Baxter, JA; Beckett, SR; Chapman, V; Finn, DP; Fone, KC; Marsden, CA | 1 |
| Cole, BE | 1 |
| Armstrong, DG; Wrobel, JS; Wu, SC | 1 |
| Robinson-Papp, J; Simpson, DM | 1 |
| Brecht, S; Courtecuisse, C; Croenlein, J; Debieuvre, C; Demyttenaere, K; Desaiah, D; Petit, C; Raskin, J | 1 |
| Abdel-Salam, OM; Elmegeed, GA; Wardakhan, WW | 1 |
| Möller, HJ; Müller, N; Riedel, M; Schennach, R | 1 |
| Abd el-Salam, OM; el-Batran, S; el-Shenawy, SM; Fakhr, IM; Radwan, MA | 1 |
| Fishbain, DA; Gonzales, J; Hall, J; Mallinckrodt, C; Meyers, AL | 1 |
| Donald, JF; Molla, AL | 1 |
| Cutting, CJ; Thornton, EJ | 1 |
| Kamiya, K; Katsumura, T; Mishima, Y; Sakaguchi, S; Sakuma, A; Tanabe, T | 1 |
| Carruette, A; Garret, C; Moussaoui, S | 1 |
| Diop, L; Junien, JL; Langlois, A; Pascaud, X; Rivière, PJ | 1 |
| Angel, F; Chevalier, E; Dahl, SG; Friese, N; Junien, JL; Pascaud, X; Riviere, PJ | 1 |
| Burnstein, Y; Higginbotham, EJ; Shelton, K | 1 |
| Clarke, S; Cunningham, D; Facchini, T; González Barón, M; James, R; Maroun, J; Maughan, TS; Schulz, J; Vincent, M; Zalcberg, J | 1 |
| Fruhstorfer, H; Nolte, H; Sommer, S | 1 |
| Cowan, A; Wheeler-Aceto, H | 2 |
| Binder, D; Enzenhofer, R; Rovenszky, F; Schnait, H; Stroissnig, H | 1 |
| Huber, R; Lühmann, R; Prügner, W | 1 |
| Cowan, A; Ianone, M; Porreca, F; Wheeler, H | 1 |
| Ghose, K | 1 |
| Hill, RG; Hughes, J; Johnson, MA; Leighton, GE; Meecham, KG | 1 |
| Daffalla, AA; Dixon, HG; el Igail, AB; el Tayeb, M; Fenwick, A; Kardaman, MW | 1 |
| Eberl, R | 1 |
| Fjalland, B; Lassen, N; Nielsen, IM; Pedersen, V; Petersen, PV | 1 |
| Beersaerts, J; Charlier, R; Colot, M; Dirks, M; Van Damme, M | 1 |
| Ekbom, K | 1 |
| Hoshino, H; Imamura, H; Maruyama, Y; Nakanishi, M | 1 |
| Imamura, H; Maruyama, Y; Nakanishi, M | 2 |
36 review(s) available for thiophenes and Ache
| Article | Year |
|---|---|
Duloxetine for fibromyalgia syndrome: a systematic review and meta-analysis.
Topics: Adult; Duloxetine Hydrochloride; Female; Fibromyalgia; Humans; Male; Middle Aged; Pain; Randomized Controlled Trials as Topic; Thiophenes; Treatment Outcome | 2023 |
Current Status of Pain Management in Parkinson's Disease.
Topics: Acetylcholine Release Inhibitors; Alanine; Analgesics; Antiparkinson Agents; Apomorphine; Benzylamines; Botulinum Toxins, Type A; Deep Brain Stimulation; Dopamine Agonists; Drug Combinations; Duloxetine Hydrochloride; Humans; Levodopa; Naloxone; Oxycodone; Pain; Pain Management; Pain Measurement; Pain Threshold; Parkinson Disease; Tetrahydronaphthalenes; Thiophenes | 2020 |
Pain in Parkinson's disease: facts and uncertainties.
Topics: Analgesics; Consensus; Humans; Pain; Parkinson Disease; Tetrahydronaphthalenes; Thiophenes; Treatment Outcome | 2018 |
The Utilization of Mu-Opioid Receptor Biased Agonists: Oliceridine, an Opioid Analgesic with Reduced Adverse Effects.
Topics: Analgesics; Analgesics, Opioid; Animals; Drug-Related Side Effects and Adverse Reactions; Humans; Pain; Receptors, Opioid, mu; Spiro Compounds; Thiophenes | 2019 |
Mechanisms and management of diabetic painful distal symmetrical polyneuropathy.
Topics: Diabetic Neuropathies; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Humans; Pain; Peripheral Nervous System Diseases; Pregabalin; Thiophenes | 2013 |
Treatment of hidradenitis supprurativa associated pain with nonsteroidal anti-inflammatory drugs, acetaminophen, celecoxib, gabapentin, pegabalin, duloxetine, and venlafaxine.
Topics: Acetaminophen; Amines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclohexanecarboxylic Acids; Cyclohexanols; Drug Therapy, Combination; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Hidradenitis Suppurativa; Humans; Pain; Pain Management; Pregabalin; Pyrazoles; Selective Serotonin Reuptake Inhibitors; Sulfonamides; Thiophenes; Venlafaxine Hydrochloride | 2013 |
Investigational drugs for the treatment of osteoarthritis.
Topics: Animals; Bone Density Conservation Agents; Disease Progression; Drug Design; Drugs, Investigational; Humans; Osteoarthritis; Pain; Thiophenes | 2015 |
Practical management strategies for the chronic pain patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Antidepressive Agents, Tricyclic; Carbamazepine; Chronic Disease; Clinical Protocols; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Drug Monitoring; Drug Tolerance; Duloxetine Hydrochloride; Family Practice; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Lidocaine; Middle Aged; Pain; Practice Guidelines as Topic; Pregabalin; Randomized Controlled Trials as Topic; Substance-Related Disorders; Thiophenes; Treatment Outcome | 2007 |
Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials.
Topics: Adrenergic Uptake Inhibitors; Diabetic Neuropathies; Duloxetine Hydrochloride; Fibromyalgia; Humans; Pain; Randomized Controlled Trials as Topic; Thiophenes; Treatment Outcome | 2008 |
The relationship between antidepressant and analgesic responses: findings from six placebo-controlled trials assessing the efficacy of duloxetine in patients with major depressive disorder.
Topics: Adult; Analgesia; Analgesics; Antidepressive Agents; Clinical Trials, Phase III as Topic; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Male; Pain; Placebos; Randomized Controlled Trials as Topic; Thiophenes; Treatment Outcome | 2008 |
Central sensitisation phenomena in primary headaches: overview of a preventive therapeutic approach.
Topics: Animals; Duloxetine Hydrochloride; Fibromyalgia; Headache; Humans; Migraine Disorders; Pain; Pain Management; Sleep Deprivation; Thiophenes | 2008 |
Meta-analysis of duloxetine vs. pregabalin and gabapentin in the treatment of diabetic peripheral neuropathic pain.
Topics: Amines; Analgesics; Analysis of Variance; Bayes Theorem; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Duloxetine Hydrochloride; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pain; Pain Measurement; Peripheral Nervous System; Pregabalin; Randomized Controlled Trials as Topic; Thiophenes; Treatment Outcome | 2009 |
Comparative pain and mood effects in patients with comorbid fibromyalgia and major depressive disorder: secondary analyses of four pooled randomized controlled trials of duloxetine.
Topics: Adult; Affect; Antidepressive Agents; Comorbidity; Depressive Disorder, Major; Double-Blind Method; Duloxetine Hydrochloride; Female; Fibromyalgia; Humans; Male; Middle Aged; Pain; Pain Measurement; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Severity of Illness Index; Thiophenes | 2011 |
Treating diabetic peripheral neuropathic pain.
Topics: Analgesics, Opioid; Anticonvulsants; Antidepressive Agents; Complementary Therapies; Diabetic Neuropathies; Drug Interactions; Drug Therapy, Combination; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Humans; Pain; Pain Measurement; Pregabalin; Recovery of Function; Thiophenes | 2010 |
Duloxetine for the treatment of fibromyalgia.
Topics: Clinical Trials as Topic; Duloxetine Hydrochloride; Fibromyalgia; Humans; Pain; Pain Measurement; Thiophenes | 2010 |
Weight change with long-term duloxetine use in chronic painful conditions: an analysis of 16 clinical studies.
Topics: Aged; Analgesics; Arthralgia; Chronic Disease; Controlled Clinical Trials as Topic; Diabetic Neuropathies; Duloxetine Hydrochloride; Female; Fibromyalgia; Humans; Knee Joint; Low Back Pain; Male; Middle Aged; Osteoarthritis, Knee; Pain; Thiophenes; Weight Gain; Weight Loss | 2011 |
New hope in the treatment of painful symptoms in depression.
Topics: Animals; Antidepressive Agents; Clinical Trials as Topic; Cyclohexanols; Cyclopropanes; Depressive Disorder; Duloxetine Hydrochloride; Humans; Milnacipran; Pain; Thiophenes; Venlafaxine Hydrochloride | 2003 |
Physical symptoms of depression: unmet needs in special populations.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Age Factors; Antidepressive Agents; Child; Comorbidity; Cyclohexanols; Delivery of Health Care; Depressive Disorder; Diagnosis, Differential; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Pain; Poverty; Selective Serotonin Reuptake Inhibitors; Sex Factors; Thiophenes; Venlafaxine Hydrochloride | 2003 |
Efficacy and tolerability of duloxetine, a novel dual reuptake inhibitor, in the treatment of major depressive disorder.
Topics: Adrenergic Uptake Inhibitors; Clinical Trials as Topic; Depressive Disorder; Duloxetine Hydrochloride; Humans; Multicenter Studies as Topic; Norepinephrine; Pain; Selective Serotonin Reuptake Inhibitors; Serotonin; Somatoform Disorders; Thiophenes; Treatment Outcome | 2003 |
Physical symptoms comorbid with depression and the new antidepressant duloxetine.
Topics: Adrenergic Uptake Inhibitors; Antidepressive Agents; Anxiety Disorders; Comorbidity; Depressive Disorder; Duloxetine Hydrochloride; Gastrointestinal Diseases; Humans; Mood Disorders; Norepinephrine; Pain; Psychophysiologic Disorders; Selective Serotonin Reuptake Inhibitors; Serotonin; Sleep Wake Disorders; Thiophenes; Treatment Outcome | 2003 |
The effect of duloxetine on painful physical symptoms in depressed patients: do improvements in these symptoms result in higher remission rates?
Topics: Adult; Antidepressive Agents; Comorbidity; Depressive Disorder; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Male; Multicenter Studies as Topic; Pain; Pain Measurement; Placebos; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Severity of Illness Index; Thiophenes; Treatment Outcome | 2004 |
Common pathways of depression and pain.
Topics: Adrenergic Uptake Inhibitors; Antidepressive Agents; Brain; Chronic Disease; Cyclohexanols; Depressive Disorder; Diabetic Neuropathies; Duloxetine Hydrochloride; Humans; Neurodegenerative Diseases; Neuronal Plasticity; Neurons; Norepinephrine; Pain; Recurrence; Selective Serotonin Reuptake Inhibitors; Serotonin; Thiophenes; Venlafaxine Hydrochloride | 2004 |
Clinical experience with dual action antidepressants in different chronic pain syndromes.
Topics: Antidepressive Agents; Chronic Disease; Cyclohexanols; Cyclopropanes; Duloxetine Hydrochloride; Humans; Milnacipran; Pain; Thiophenes; Venlafaxine Hydrochloride | 2004 |
Duloxetine: pharmacoeconomic implications of an antidepressant that alleviates painful physical symptoms.
Topics: Antidepressive Agents; Depressive Disorder, Major; Duloxetine Hydrochloride; Economics, Pharmaceutical; Humans; Pain; Pain Measurement; Thiophenes | 2005 |
Duloxetine: a new selective and dual-acting antidepressant.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Depression; Drug Evaluation, Preclinical; Duloxetine Hydrochloride; Humans; Pain; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Thiophenes; Treatment Outcome | 2006 |
Efficacy of duloxetine in painful symptoms: an analgesic or antidepressant effect?
Topics: Analgesics; Antidepressive Agents; Chronic Disease; Depressive Disorder; Diabetic Neuropathies; Duloxetine Hydrochloride; Fibromyalgia; Humans; Pain; Thiophenes; Treatment Outcome | 2006 |
[Dual acting reuptake inhibitors in the treatment of depression and pain].
Topics: Adrenergic Uptake Inhibitors; Antidepressive Agents; Chronic Disease; Depression; Diabetes Complications; Diabetes Mellitus, Type 2; Duloxetine Hydrochloride; Humans; Norepinephrine; Pain; Selective Serotonin Reuptake Inhibitors; Serotonin; Thiophenes; Treatment Outcome | 2006 |
[Duloxetine, a new therapeutic option for diabetic peripheral neuropathic pain].
Topics: Adrenergic Uptake Inhibitors; Diabetic Neuropathies; Duloxetine Hydrochloride; Humans; Pain; Quality of Life; Risk Factors; Selective Serotonin Reuptake Inhibitors; Thiophenes; Treatment Outcome | 2006 |
Update on pharmacotherapy guidelines for treatment of neuropathic pain.
Topics: Analgesics; Animals; Cannabidiol; Chronic Disease; Dronabinol; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Guidelines as Topic; Humans; Pain; Peripheral Nervous System Diseases; Pregabalin; Thiophenes | 2007 |
Efficacy of duloxetine in the treatment of generalized anxiety disorder in patients with clinically significant pain symptoms.
Topics: Adult; Antidepressive Agents; Anxiety Disorders; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Pain; Pain Measurement; Personality Inventory; Randomized Controlled Trials as Topic; Thiophenes; Treatment Outcome | 2008 |
Diabetic peripheral neuropathic pain: recognition and management.
Topics: Antidepressive Agents; Diabetic Foot; Diabetic Neuropathies; Duloxetine Hydrochloride; Humans; Pain; Thiophenes | 2007 |
Assessing the impact of pharmacologic intervention on the quality of life in diabetic peripheral neuropathic pain and fibromyalgia.
Topics: Antidepressive Agents; Diabetic Neuropathies; Duloxetine Hydrochloride; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Pain; Pregabalin; Quality of Life; Randomized Controlled Trials as Topic; Thiophenes | 2007 |
Safety profile of treatment in diabetic peripheral neuropathic pain.
Topics: Administration, Topical; Analgesics; Anesthetics, Local; Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Capsaicin; Cyclohexanols; Diabetic Neuropathies; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Humans; Pain; Pregabalin; Thiophenes; Venlafaxine Hydrochloride | 2007 |
Duloxetine does not relieve painful physical symptoms in depression: a meta-analysis.
Topics: Adult; Analgesics; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Duloxetine Hydrochloride; Humans; Pain; Pain Measurement; Paroxetine; Psychophysiologic Disorders; Randomized Controlled Trials as Topic; Somatoform Disorders; Thiophenes; Treatment Outcome | 2008 |
Duloxetine in the treatment of major psychiatric and neuropathic disorders.
Topics: Antidepressive Agents; Anxiety; Clinical Trials as Topic; Depressive Disorder, Major; Duloxetine Hydrochloride; Humans; Pain; Peripheral Nervous System Diseases; Practice Patterns, Physicians'; Thiophenes; Treatment Outcome; Urinary Incontinence, Stress | 2008 |
Efficacy, tolerability and management of raltitrexed (Tomudex) monotherapy in patients with advanced colorectal cancer. a review of phase II/III trials.
Topics: Adult; Aged; Aged, 80 and over; Anemia; Antimetabolites, Antineoplastic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Diarrhea; Female; Humans; Leukopenia; Male; Middle Aged; Nausea; Neutropenia; Pain; Quinazolines; Randomized Controlled Trials as Topic; Survival Analysis; Thiophenes; Vomiting | 2002 |
52 trial(s) available for thiophenes and Ache
| Article | Year |
|---|---|
Oliceridine (TRV130), a Novel G Protein-Biased Ligand at the μ-Opioid Receptor, Demonstrates a Predictable Relationship Between Plasma Concentrations and Pain Relief. I: Development of a Pharmacokinetic/Pharmacodynamic Model.
Topics: Adult; Aged; Cytochrome P-450 CYP2D6; Double-Blind Method; Female; Hallux Valgus; Humans; Male; Middle Aged; Models, Biological; Pain; Pain Measurement; Pain, Postoperative; Spiro Compounds; Thiophenes; Treatment Outcome; Young Adult | 2018 |
A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Biomarkers, Tumor; Cell Adhesion Molecules; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Microfilament Proteins; Middle Aged; Pain; Phosphoproteins; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prognosis; Purinergic P2Y Receptor Antagonists; Thiophenes; Young Adult | 2013 |
Effect of prophylactic intraocular pressure-lowering medication on pain during cataract surgery.
Topics: Acetazolamide; Adult; Aged; Aged, 80 and over; Amides; Antihypertensive Agents; Bimatoprost; Brimonidine Tartrate; Cataract; Cloprostenol; Combined Modality Therapy; Drug Combinations; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Pain; Phacoemulsification; Postoperative Period; Prospective Studies; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiophenes; Timolol; Travoprost | 2013 |
Responsiveness of the Intermittent and Constant Osteoarthritis Pain (ICOAP) scale in a trial of duloxetine for treatment of osteoarthritis knee pain.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Therapy, Combination; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Osteoarthritis, Knee; Pain; Pain Measurement; Thiophenes; Treatment Outcome | 2013 |
Safety and efficacy of duloxetine treatment in older and younger patients with osteoarthritis knee pain: a post hoc, subgroup analysis of two randomized, placebo-controlled trials.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Analgesics; Dizziness; Dose-Response Relationship, Drug; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Osteoarthritis, Knee; Pain; Pain Measurement; Thiophenes; Treatment Outcome | 2013 |
Duloxetine and pregabalin: high-dose monotherapy or their combination? The "COMBO-DN study"--a multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain.
Topics: Aged; Analgesics; Diabetic Neuropathies; Double-Blind Method; Drug Therapy, Combination; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Humans; Internationality; Male; Middle Aged; Pain; Pregabalin; Thiophenes; Treatment Outcome | 2013 |
Relationship between major depressive disorder and associated painful physical symptoms: analysis of data from two pooled placebo-controlled, randomized studies of duloxetine.
Topics: Adult; Analgesics; Antidepressive Agents; Depressive Disorder, Major; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Pain; Statistics as Topic; Thiophenes | 2013 |
[Impact of duloxetine on depression and anxiety in patients with ankylosing spondylitis: a case-control study].
Topics: Adult; Analgesics; Antidepressive Agents; Anxiety; Depression; Duloxetine Hydrochloride; Female; Humans; Male; Pain; Spondylitis, Ankylosing; Thiophenes; Young Adult | 2013 |
A randomized, double-blind, placebo-controlled trial of duloxetine for the treatment of pain in patients with multiple sclerosis.
Topics: Adolescent; Adult; Analgesics; Depressive Disorder, Major; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Pain; Thiophenes; Treatment Outcome | 2014 |
Acute and long-term treatment of late-life major depressive disorder: duloxetine versus placebo.
Topics: Age of Onset; Aged; Aged, 80 and over; Antidepressive Agents; Depressive Disorder, Major; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Male; Pain; Psychiatric Status Rating Scales; Thiophenes | 2014 |
Rotigotine transdermal system and evaluation of pain in patients with Parkinson's disease: a post hoc analysis of the RECOVER study.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Dopamine Agonists; Female; Humans; Male; Middle Aged; Pain; Pain Measurement; Parkinson Disease; Prospective Studies; Tetrahydronaphthalenes; Thiophenes | 2014 |
Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers.
Topics: Adolescent; Adult; Analgesia; Analgesics, Opioid; Cross-Over Studies; Dizziness; Dose-Response Relationship, Drug; Double-Blind Method; Headache; Healthy Volunteers; Humans; Male; Middle Aged; Morphine; Pain; Spiro Compounds; Thiophenes; Vomiting; Young Adult | 2014 |
Patients' perception of Parkinson's disease-associated pain following initiation of rotigotine: a multicenter non-interventional study.
Topics: Activities of Daily Living; Administration, Cutaneous; Aged; Aged, 80 and over; Austria; Dopamine Agonists; Female; Follow-Up Studies; Germany; Humans; Male; Middle Aged; Pain; Parkinson Disease; Surveys and Questionnaires; Tetrahydronaphthalenes; Thiophenes | 2017 |
Predictors of relapse in a study of duloxetine treatment in patients with major depressive disorder.
Topics: Acute Disease; Adult; Antidepressive Agents; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Double-Blind Method; Drug Administration Schedule; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Pain; Pain Measurement; Predictive Value of Tests; Prevalence; Prospective Studies; Recurrence; Severity of Illness Index; Thiophenes | 2009 |
The relationship between functional outcomes and the treatment of anxious and painful somatic symptoms in patients with generalized anxiety disorder.
Topics: Adult; Antidepressive Agents; Anxiety Disorders; Dose-Response Relationship, Drug; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Pain; Pain Measurement; Placebos; Psychophysiologic Disorders; Thiophenes; Treatment Outcome | 2008 |
Switching to duloxetine in selective serotonin reuptake inhibitor non- and partial-responders: effects on painful physical symptoms of depression.
Topics: Activities of Daily Living; Antidepressive Agents; Depressive Disorder, Major; Duloxetine Hydrochloride; Europe; Female; Health Surveys; Humans; Male; Middle Aged; Pain; Pain Measurement; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index; Surveys and Questionnaires; Thiophenes; Time Factors; Treatment Outcome | 2009 |
A single-blind, placebo run-in study of duloxetine for activity-limiting osteoarthritis pain.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antidepressive Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Osteoarthritis; Pain; Pain Measurement; Single-Blind Method; Thiophenes; Time Factors; Treatment Outcome | 2009 |
Long-term safety, tolerability, and efficacy of duloxetine in the treatment of fibromyalgia.
Topics: Antidepressive Agents; Depression; Disability Evaluation; Double-Blind Method; Duloxetine Hydrochloride; Female; Fibromyalgia; Health Status; Humans; Male; Middle Aged; Pain; Pain Measurement; Thiophenes; Treatment Outcome | 2010 |
[Cymbalta in the treatment of chronic pain syndromes].
Topics: Adult; Antidepressive Agents; Chronic Disease; Depression; Duloxetine Hydrochloride; Follow-Up Studies; Humans; Middle Aged; Pain; Pain Measurement; Syndrome; Thiophenes; Treatment Outcome | 2009 |
Effectiveness of the psychological and pharmacological treatment of catastrophization in patients with fibromyalgia: a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Analgesics; Antidepressive Agents; Cognitive Behavioral Therapy; Combined Modality Therapy; Depression; Duloxetine Hydrochloride; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Middle Aged; Pain; Pain Management; Pain Measurement; Pregabalin; Psychiatric Status Rating Scales; Research Design; Spain; Thiophenes; Time Factors; Treatment Outcome; Young Adult | 2009 |
A 1-year safety and efficacy study of duloxetine in patients with fibromyalgia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Comorbidity; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Duloxetine Hydrochloride; Female; Fibromyalgia; Humans; Internationality; Male; Middle Aged; Pain; Pain Measurement; Thiophenes; Treatment Outcome; Young Adult | 2009 |
Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: a 13-week, randomized, placebo-controlled trial.
Topics: Aged; Analgesics; Antidepressive Agents; Depression; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Knee; Male; Middle Aged; Osteoarthritis; Pain; Pain Measurement; Psychiatric Status Rating Scales; Thiophenes; Treatment Outcome | 2009 |
Pseudohypoalgesia on the skin: a novel view on the paradox of pain perception in depression.
Topics: Adult; Depressive Disorder, Major; Duloxetine Hydrochloride; Female; Hot Temperature; Humans; Male; Middle Aged; Pain; Pain Measurement; Pain Perception; Pain Threshold; Skin Physiological Phenomena; Thiophenes | 2011 |
Estimation of minimum clinically important difference for pain in fibromyalgia.
Topics: Adult; Double-Blind Method; Duloxetine Hydrochloride; Female; Fibromyalgia; Humans; Male; Middle Aged; Pain; Pain Measurement; Severity of Illness Index; Thiophenes | 2011 |
Clinical and functional outcomes in patients with major depressive disorder and painful physical symptoms switched to treatment with duloxetine.
Topics: Adult; Depressive Disorder, Major; Drug Substitution; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Pain; Pain Measurement; Selective Serotonin Reuptake Inhibitors; Thiophenes; Treatment Outcome | 2011 |
Pilot study of duloxetine for treatment of aromatase inhibitor-associated musculoskeletal symptoms.
Topics: Adult; Aged; Aromatase Inhibitors; Chronic Pain; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Musculoskeletal Diseases; Pain; Pilot Projects; Postmenopause; Selective Serotonin Reuptake Inhibitors; Thiophenes | 2011 |
Early improvement in pain predicts pain response at endpoint in patients with fibromyalgia.
Topics: Adult; Dopamine Uptake Inhibitors; Double-Blind Method; Duloxetine Hydrochloride; Female; Fibromyalgia; Humans; Male; Middle Aged; Pain; Pain Measurement; Predictive Value of Tests; Regression Analysis; Thiophenes; Time Factors | 2011 |
Duloxetine versus placebo in the treatment of major depressive disorder and associated painful physical symptoms: a replication study.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Depressive Disorder, Major; Double-Blind Method; Duloxetine Hydrochloride; Humans; Male; Middle Aged; Pain; Puerto Rico; Remission Induction; Thiophenes; Time Factors; United States | 2011 |
A randomized placebo-controlled trial of duloxetine in patients with major depressive disorder and associated painful physical symptoms.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents; Depressive Disorder, Major; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Pain; Remission Induction; Thiophenes; Time Factors | 2011 |
Early reduction in painful physical symptoms is associated with improvements in long-term depression outcomes in patients treated with duloxetine.
Topics: Antidepressive Agents; Depression; Duloxetine Hydrochloride; Female; Humans; International Classification of Diseases; Male; Middle Aged; Outpatients; Pain; Pain Measurement; Prospective Studies; Severity of Illness Index; Thiophenes | 2011 |
[Biological age and the pain syndrome at diabetic polyneuropathy].
Topics: Adult; Aging; Amines; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Duloxetine Hydrochloride; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pain; Selective Serotonin Reuptake Inhibitors; Syndrome; Thiophenes; Treatment Outcome | 2011 |
Duloxetine added to oral nonsteroidal anti-inflammatory drugs for treatment of knee pain due to osteoarthritis: results of a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Oral; Adrenergic Uptake Inhibitors; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Therapy, Combination; Duloxetine Hydrochloride; Female; Humans; Knee; Male; Middle Aged; Osteoarthritis, Knee; Pain; Pain Management; Thiophenes; Time Factors | 2011 |
Early vs. conventional switching of antidepressants in patients with MDD and moderate to severe pain: a double-blind randomized study.
Topics: Activities of Daily Living; Adult; Aged; Antidepressive Agents; Citalopram; Depressive Disorder, Major; Double-Blind Method; Drug Substitution; Duloxetine Hydrochloride; Female; Humans; Induction Chemotherapy; Male; Middle Aged; Pain; Pain Measurement; Thiophenes; Treatment Outcome; Young Adult | 2012 |
Randomized, placebo-controlled comparison of amitriptyline, duloxetine, and pregabalin in patients with chronic diabetic peripheral neuropathic pain: impact on pain, polysomnographic sleep, daytime functioning, and quality of life.
Topics: Aged; Amitriptyline; Diabetic Neuropathies; Double-Blind Method; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pain; Pregabalin; Quality of Life; Sleep; Thiophenes; Treatment Outcome | 2012 |
Acute and chronic ocular symptoms of dorzolamide 2% compared with placebo.
Topics: Acute Disease; Adult; Carbonic Anhydrase Inhibitors; Chronic Disease; Double-Blind Method; Eye Diseases; Female; Humans; Male; Ophthalmic Solutions; Pain; Pain Measurement; Sulfonamides; Thiophenes; Time Factors | 2003 |
Short-term ocular tolerability of dorzolamide 2% and brinzolamide 1% vs placebo in primary open-angle glaucoma and ocular hypertension subjects.
Topics: Adult; Aged; Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; Glaucoma, Open-Angle; Humans; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Pain; Pain Measurement; Prospective Studies; Severity of Illness Index; Sulfonamides; Thiazines; Thiophenes | 2004 |
The effect of duloxetine on painful physical symptoms in depressed patients: do improvements in these symptoms result in higher remission rates?
Topics: Adult; Antidepressive Agents; Comorbidity; Depressive Disorder; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Male; Multicenter Studies as Topic; Pain; Pain Measurement; Placebos; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Severity of Illness Index; Thiophenes; Treatment Outcome | 2004 |
Duloxetine 60 mg once-daily in the treatment of painful physical symptoms in patients with major depressive disorder.
Topics: Administration, Oral; Adult; Antidepressive Agents; Depressive Disorder, Major; Double-Blind Method; Drug Administration Schedule; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Pain; Placebos; Severity of Illness Index; Thiophenes; Treatment Outcome | 2005 |
A randomized controlled trial of duloxetine in diabetic peripheral neuropathic pain.
Topics: Acetaminophen; Adrenergic Uptake Inhibitors; Aged; Analgesics, Non-Narcotic; Diabetic Neuropathies; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Neuralgia; Norepinephrine; Pain; Palliative Care; Peripheral Nervous System Diseases; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index; Thiophenes; Treatment Outcome | 2006 |
A comparison of latanoprost monotherapy with a combination therapy of timolol/dorzolamide in patients with primary open-angle glaucoma.
Topics: Adult; Aged; Aged, 80 and over; Drug Therapy, Combination; Eye Color; Eyelashes; Female; Glaucoma, Open-Angle; Humans; Hyperemia; Intraocular Pressure; Latanoprost; Male; Middle Aged; Pain; Prostaglandins F, Synthetic; Pruritus; Sulfonamides; Thiophenes; Timolol | 2006 |
Once-daily duloxetine 60 mg in the treatment of major depressive disorder: multicenter, double-blind, randomized, paroxetine-controlled, non-inferiority trial in China, Korea, Taiwan and Brazil.
Topics: Activities of Daily Living; Adult; Antidepressive Agents; Antidepressive Agents, Second-Generation; Blood Pressure; Brazil; China; Depressive Disorder, Major; Double-Blind Method; Duloxetine Hydrochloride; Female; Heart Rate; Humans; Korea; Male; Middle Aged; Pain; Pain Measurement; Paroxetine; Psychiatric Status Rating Scales; Taiwan; Thiophenes; Weight Gain | 2007 |
Efficacy of duloxetine on cognition, depression, and pain in elderly patients with major depressive disorder: an 8-week, double-blind, placebo-controlled trial.
Topics: Age Factors; Aged; Antidepressive Agents; Back Pain; Cognition Disorders; Comorbidity; Depressive Disorder, Major; Double-Blind Method; Duloxetine Hydrochloride; Female; Geriatric Assessment; Humans; Male; Neuropsychological Tests; Pain; Pain Measurement; Placebos; Psychiatric Status Rating Scales; Secondary Prevention; Thiophenes; Treatment Outcome | 2007 |
The safety and tolerability of duloxetine in depressed elderly patients with and without medical comorbidity.
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Arthritis; Cardiovascular Diseases; Depressive Disorder, Major; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Male; Pain; Pain Measurement; Severity of Illness Index; Thiophenes; Treatment Outcome | 2007 |
Treatment of depression and menopause-related symptoms with the serotonin-norepinephrine reuptake inhibitor duloxetine.
Topics: Adult; Anxiety; Depressive Disorder, Major; Duloxetine Hydrochloride; Female; Hot Flashes; Humans; Middle Aged; Pain; Postmenopause; Selective Serotonin Reuptake Inhibitors; Single-Blind Method; Sleep Wake Disorders; Thiophenes; Treatment Outcome | 2007 |
Efficacy and safety of duloxetine 60 mg once daily in the treatment of pain in patients with major depressive disorder and at least moderate pain of unknown etiology: a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Pain; Pain Measurement; Severity of Illness Index; Thiophenes | 2007 |
A comparative double-blind study of tiaprofenic acid and aspirin in the treatment of muscular rheumatism, fibrositis, sprains and soft tissue injuries in general practice.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Double-Blind Method; Female; Fibromyalgia; Humans; Male; Middle Aged; Pain; Propionates; Sprains and Strains; Thiophenes; Wounds and Injuries | 1980 |
A comparative trial of tiaprofenic acid ('Surgam') versus aspirin in the control of pain following injury.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Pain; Propionates; Thiophenes; Wounds and Injuries | 1981 |
Therapeutic effect of ticlopidine, a new inhibitor of platelet aggregation, on chronic arterial occlusive diseases, a double-blind study versus placebo.
Topics: Arterial Occlusive Diseases; Arteriosclerosis; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Elbow; Female; Foot; Humans; Ischemia; Knee; Male; Middle Aged; Pain; Placebos; Platelet Aggregation; Skin Ulcer; Thiophenes; Thromboangiitis Obliterans; Ticlopidine | 1982 |
[Comparative studies of the local anaesthetic action of carticaine 1% and mepivacaine 1% (author's transl)].
Topics: Adult; Anesthetics, Local; Cold Temperature; Double-Blind Method; Drug Evaluation; Hot Temperature; Humans; Mepivacaine; Pain; Thiophenes; Ulnar Nerve | 1978 |
Eltenac, a new anti-inflammatory and analgesic drug for horses: clinical aspects.
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Edema; Female; Horse Diseases; Horses; Inflammation; Lameness, Animal; Male; Orchiectomy; Pain; Postoperative Complications; Thiophenes | 1991 |
Dose-finding trial using Oltipraz to treat schoolchildren infected with Schistosoma mansoni in Gezira, Sudan.
Topics: Abdomen; Administration, Oral; Child; Clinical Trials as Topic; Feces; Fingers; Follow-Up Studies; Humans; Pain; Parasite Egg Count; Pyrazines; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Thiones; Thiophenes; Vision Disorders | 1985 |
[Carticaine in the therapie of pain (author's transl)].
Topics: Adult; Aged; Analgesia; Anesthesia, Conduction; Anesthetics, Local; Blood Pressure; Female; Humans; Joint Diseases; Male; Mepivacaine; Middle Aged; Neuralgia; Pain; Propylamines; Pulse; Thiophenes | 1974 |
97 other study(ies) available for thiophenes and Ache
| Article | Year |
|---|---|
Rotigotine-loaded microspheres exerts the antinociceptive effect via central dopaminergic system.
Topics: Analgesics; Animals; Carrageenan; Corpus Striatum; Disease Models, Animal; Domperidone; Dopamine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Inflammation; Injections; Male; Microspheres; Naloxone; Narcotic Antagonists; Pain; Periaqueductal Gray; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Stress, Mechanical; Temperature; Tetrahydronaphthalenes; Thiophenes | 2021 |
Angiotensin II type 2 receptor pharmacological agonist, C21, reduces the inflammation and pain hypersensitivity in mice with joint inflammatory pain.
Topics: Animals; Arthritis; Hyperalgesia; Imidazoles; Inflammation; Mice; Microglia; Pain; Receptor, Angiotensin, Type 2; Spinal Cord; Sulfonamides; Thiophenes | 2022 |
Molecular Dynamics Simulations to Investigate How PZM21 Affects the Conformational State of the μ-Opioid Receptor Upon Activation.
Topics: Analgesia; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; GTP-Binding Proteins; Humans; Ligands; Molecular Dynamics Simulation; Morphine; Pain; Receptors, Opioid, mu; Spiro Compounds; Thiophenes; Urea | 2020 |
Approval of oliceridine (TRV130) for intravenous use in moderate to severe pain in adults.
Topics: Drug Approval; Humans; Injections, Intravenous; Pain; Spiro Compounds; Thiophenes | 2020 |
Oliceridine (Olinvyk) - a new opioid for severe pain.
Topics: Analgesics, Opioid; Drug Interactions; Humans; Opioid-Related Disorders; Pain; Randomized Controlled Trials as Topic; Spiro Compounds; Thiophenes | 2021 |
Some effects of putative G-protein biased mu-opioid receptor agonists in male rhesus monkeys.
Topics: Analgesics; Animals; Behavior, Animal; Drug Evaluation; GTP-Binding Proteins; Macaca mulatta; Male; Opioid-Related Disorders; Oximetry; Pain; Receptors, Opioid, mu; Respiration; Spiro Compounds; Thiophenes | 2021 |
Anti-inflammatory and anti-nociceptive effects of strontium ranelate on the zymosan-induced temporomandibular joint inflammatory hypernociception in rats depend on TNF-α inhibition.
Topics: Animals; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Inflammation; Interleukin-1beta; Male; Pain; Protoporphyrins; Rats; Rats, Wistar; Temporomandibular Joint Disorders; Thiophenes; Tumor Necrosis Factor-alpha; Zymosan | 2017 |
'Biased' opioids could yield safer pain relief.
Topics: Analgesics, Opioid; Clinical Trials as Topic; Drug Approval; Drug Overdose; Humans; Pain; Pain Management; Receptors, Opioid, mu; Respiration; Respiratory Insufficiency; Spiro Compounds; Thiophenes; United States; United States Food and Drug Administration | 2017 |
Oliceridine, a Novel G Protein-Biased Ligand at the μ-Opioid Receptor, Demonstrates a Predictable Relationship Between Plasma Concentrations and Pain Relief. II: Simulation of Potential Phase 3 Study Designs Using a Pharmacokinetic/Pharmacodynamic Model.
Topics: Analgesics; Clinical Protocols; Clinical Trials as Topic; Computer Simulation; Cytochrome P-450 CYP2D6; Humans; Ligands; Models, Biological; Pain; Pain Measurement; Pain, Postoperative; Spiro Compounds; Thiophenes | 2018 |
The G-protein biased mu-opioid agonist, TRV130, produces reinforcing and antinociceptive effects that are comparable to oxycodone in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; GTP-Binding Proteins; Male; Morphine; Oxycodone; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reinforcement, Psychology; Spiro Compounds; Thiophenes; Treatment Outcome | 2018 |
[Local effects of transdermal treatment with rotigotine].
Topics: Aged; Antiparkinson Agents; Dopamine Agonists; Drug Evaluation; Drug Therapy, Combination; Equipment Failure; Erythema; Female; Humans; Male; Middle Aged; Pain; Patient Acceptance of Health Care; Retrospective Studies; Tetrahydronaphthalenes; Thiophenes; Transdermal Patch | 2013 |
Duloxetine reduces chemotherapy induced peripheral neuropathy.
Topics: Antidepressive Agents; Antineoplastic Agents; Duloxetine Hydrochloride; Humans; Pain; Peripheral Nervous System Diseases; Thiophenes | 2013 |
Cardiac syncope due to pain: report of a case responsive to duloxetine treatment.
Topics: Adult; Analgesics; Duloxetine Hydrochloride; Female; Humans; Pain; Syncope; Thiophenes; Treatment Outcome | 2013 |
Duloxetine dose escalation in patients with osteoarthritis knee pain, who were taking optimized NSAIDs.
Topics: Adrenergic Uptake Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Male; Osteoarthritis, Knee; Pain; Thiophenes | 2013 |
Add-on therapy: when two are not better than one.
Topics: Diabetic Neuropathies; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Humans; Male; Pain; Pregabalin; Thiophenes | 2013 |
Pharmacology of cannabinoid receptor agonists and a cyclooxygenase-2 inhibitor in rat bone tumor pain.
Topics: Animals; Arachidonic Acids; Bone Neoplasms; Cannabinoid Receptor Agonists; Cannabinoids; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Female; Hyperalgesia; Pain; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Spinal Cord; Thiophenes; Tibia | 2013 |
Painful traumatic trigeminal neuropathy: an open study on the pharmacotherapeutic response to stepped treatment.
Topics: Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Baclofen; Carbamazepine; Clinical Protocols; Cohort Studies; Cyclohexanecarboxylic Acids; Drug Combinations; Duloxetine Hydrochloride; Female; Follow-Up Studies; GABA-B Receptor Agonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Medical Records; Middle Aged; Nortriptyline; Pain; Pain Measurement; Pregabalin; Prognosis; Prospective Studies; Thiophenes; Treatment Outcome; Trigeminal Nerve Injuries; Trigeminal Neuralgia | 2014 |
Assessment of thermal sensitivity in rats using the thermal place preference test: description and application in the study of oxaliplatin-induced acute thermal hypersensitivity and inflammatory pain models.
Topics: Analgesics; Analgesics, Opioid; Animals; Carrageenan; Cold Temperature; Conditioning, Psychological; Disease Models, Animal; Duloxetine Hydrochloride; Hot Temperature; Hyperalgesia; Male; Morphine; Organoplatinum Compounds; Oxaliplatin; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Space Perception; Temperature; Thiophenes | 2014 |
Handling missing data in a duloxetine population pharmacokinetic/pharmacodynamic model - imputation methods and selection models.
Topics: Analgesics; Computer Simulation; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Humans; Models, Biological; Nonlinear Dynamics; Pain; Pain Measurement; Patient Dropouts; Probability; Randomized Controlled Trials as Topic; Thiophenes | 2014 |
Efficacy of drugs with different mechanisms of action in relieving spontaneous pain at rest and during movement in a rat model of osteoarthritis.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Duloxetine Hydrochloride; Gait; Iodoacetic Acid; Male; Morphine; Movement; Osteoarthritis; Pain; Rats; Rest; Thiophenes; Tramadol; Weight-Bearing | 2014 |
Individual residual symptoms and functional impairment in patients with depression.
Topics: Adult; Antidepressive Agents; Anxiety; Depression; Depressive Disorder, Major; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Pain; Sleep Wake Disorders; Thiophenes | 2014 |
An examination of the cardiac actions of PD117,302, a κ-opioid receptor agonist.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Binding, Competitive; Cardiac Pacing, Artificial; Cerebellum; Coronary Occlusion; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Guinea Pigs; Heart Conduction System; Heart Rate; Heart Ventricles; Isolated Heart Preparation; Ligands; Male; Mice, Inbred BALB C; Myocardial Contraction; Pain; Pain Threshold; Potassium Channel Blockers; Potassium Channels; Protein Binding; Pyrroles; Radioligand Assay; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sodium Channel Blockers; Sodium Channels; Thiophenes; Ventricular Function, Left; Ventricular Pressure | 2015 |
Structure-based discovery of opioid analgesics with reduced side effects.
Topics: Analgesia; Analgesics, Opioid; Animals; Drug Discovery; GTP-Binding Protein alpha Subunits, Gi-Go; HEK293 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Docking Simulation; Pain; Receptors, Opioid, mu; Spiro Compounds; Structure-Activity Relationship; Thiophenes; Urea | 2016 |
The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development.
Topics: AMP-Activated Protein Kinases; Analgesics; Anesthetics, Local; Animals; Binding Sites; Biphenyl Compounds; Drug Evaluation, Preclinical; HEK293 Cells; Hot Temperature; Humans; Male; meta-Aminobenzoates; Metformin; NAV1.7 Voltage-Gated Sodium Channel; Neural Conduction; Pain; Patch-Clamp Techniques; Pyrones; Rats; Rats, Sprague-Dawley; Reaction Time; Recombinant Fusion Proteins; Resveratrol; Sensory Receptor Cells; Sodium Channel Blockers; Stilbenes; Thiazoles; Thiophenes; Trigeminal Ganglion | 2017 |
Measurement of pain and medication effect in a study of duloxetine.
Topics: Antidepressive Agents; Depressive Disorder, Major; Duloxetine Hydrochloride; Humans; Pain; Pain Measurement; Prevalence; Severity of Illness Index; Thiophenes | 2008 |
Thiophene bioisosteres of spirocyclic sigma receptor ligands. 1. N-substituted spiro[piperidine-4,4'-thieno[3,2-c]pyrans].
Topics: Alkylation; Animals; Cyclization; Ligands; Mice; Models, Molecular; Molecular Structure; Oxidation-Reduction; Pain; Piperidines; Protein Binding; Pyrans; Rats; Receptors, sigma; Spiro Compounds; Structure-Activity Relationship; Thiophenes | 2008 |
Multiplicative interactions to enhance gabapentin to treat neuropathic pain.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Indans; Injections, Spinal; Ligation; Male; Neurotransmitter Uptake Inhibitors; Nootropic Agents; Pain; Pain Measurement; Peripheral Nervous System Diseases; Physical Stimulation; Piperidines; Postural Balance; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Spinal Nerves; Thiophenes | 2008 |
[Chronic pain and depression].
Topics: Adrenergic Uptake Inhibitors; Antidepressive Agents; Chronic Disease; Depressive Disorder, Major; Duloxetine Hydrochloride; Humans; Pain; Prevalence; Thiophenes | 2008 |
Successful pain relief of cutaneous leiomyomata due to reed syndrome with the combination treatment of pregabalin and duloxetine.
Topics: Adult; Analgesics, Non-Narcotic; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Humans; Leiomyoma; Pain; Pregabalin; Selective Serotonin Reuptake Inhibitors; Skin Neoplasms; Thiophenes | 2009 |
The short- and long-term effect of duloxetine on painful physical symptoms in patients with generalized anxiety disorder: results from three clinical trials.
Topics: Adult; Antidepressive Agents; Anxiety Disorders; Double-Blind Method; Duloxetine Hydrochloride; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pain; Pain Measurement; Randomized Controlled Trials as Topic; Secondary Prevention; Somatoform Disorders; Thiophenes; Treatment Outcome | 2009 |
Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models.
Topics: Amines; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Axotomy; Carrageenan; Cyclohexanecarboxylic Acids; Duloxetine Hydrochloride; Edema; Freund's Adjuvant; Gabapentin; Gait; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Indomethacin; Inflammation; Male; Morphine; Neuralgia; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Thiophenes | 2009 |
Comparison of mechanical allodynia and the affective component of inflammatory pain in rats.
Topics: Analgesics, Non-Narcotic; Animals; Behavior, Animal; Celecoxib; Central Nervous System Agents; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Escape Reaction; Fluoxetine; Inflammation; Male; Motor Activity; Neuropsychological Tests; Pain; Pain Measurement; Physical Stimulation; Pyrazoles; Rats; Rats, Sprague-Dawley; Scopolamine; Sulfonamides; Thiophenes; Treatment Outcome | 2010 |
What makes patients with fibromyalgia feel better? Correlations between Patient Global Impression of Improvement and changes in clinical symptoms and function: a pooled analysis of 4 randomized placebo-controlled trials of duloxetine.
Topics: Antidepressive Agents; Duloxetine Hydrochloride; Fibromyalgia; Humans; Pain; Pain Measurement; Randomized Controlled Trials as Topic; Surveys and Questionnaires; Thiophenes | 2009 |
Comparison of milnacipran, duloxetine and pregabalin in the formalin pain test and in a model of stress-induced ultrasonic vocalizations in rats.
Topics: Adrenergic Uptake Inhibitors; Analgesics; Analysis of Variance; Animals; Cyclopropanes; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Electroshock; Formaldehyde; gamma-Aminobutyric Acid; Male; Milnacipran; Pain; Pain Measurement; Pregabalin; Rats; Rats, Sprague-Dawley; Stress, Physiological; Thiophenes; Vocalization, Animal | 2010 |
Duloxetine in treating medically unexplained pain and Raynaud's phenomenon.
Topics: Antidepressive Agents; Duloxetine Hydrochloride; Female; Humans; Middle Aged; Off-Label Use; Pain; Raynaud Disease; Thiophenes; Treatment Outcome | 2009 |
Pharmacological treatment of fibromyalgia syndrome: new developments.
Topics: Age Factors; Analgesics, Opioid; Calcium Channel Blockers; Clinical Trials as Topic; Cognitive Behavioral Therapy; Combined Modality Therapy; Dopamine Agonists; Duloxetine Hydrochloride; Exercise; Exercise Therapy; Fatigue; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Pain; Pain Measurement; Pain Threshold; Pregabalin; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Research Design; Self Care; Thiophenes; Treatment Outcome | 2010 |
[Expel the fear of pain. Breaking of chronicity by re-learning].
Topics: Analgesics; Clinical Trials as Topic; Diabetic Neuropathies; Duloxetine Hydrochloride; Fear; Humans; Pain; Selective Serotonin Reuptake Inhibitors; Thiophenes; Time Factors; Treatment Outcome | 2009 |
The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist.
Topics: Analgesics; Animals; Benzoates; Cyclopropanes; Half-Life; Humans; Magnetic Resonance Spectroscopy; Male; Pain; Prostaglandin Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Structure-Activity Relationship; Thiophenes | 2010 |
Management of depression in the presence of pain symptoms.
Topics: Antidepressive Agents; Brain; Chronic Disease; Clinical Trials as Topic; Combined Modality Therapy; Comorbidity; Cyclohexanols; Cyclopropanes; Depressive Disorder, Major; Drug Therapy, Combination; Duloxetine Hydrochloride; Fibromyalgia; Humans; Milnacipran; Mind-Body Relations, Metaphysical; Norepinephrine; Pain; Psychotherapy; Serotonin; Thiophenes; Treatment Outcome; Venlafaxine Hydrochloride | 2010 |
[Focus on treatment success of depressed patients. Early and significant pain reduction improves chances for remission].
Topics: Antidepressive Agents; Depressive Disorder; Duloxetine Hydrochloride; Humans; Long-Term Care; Pain; Thiophenes | 2010 |
Selective potentiation of gabapentin-mediated antinociception in the rat formalin test by the nicotinic acetylcholine receptor agonist ABT-594.
Topics: Amines; Analgesics; Animals; Azetidines; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Duloxetine Hydrochloride; Exploratory Behavior; Gabapentin; gamma-Aminobutyric Acid; Male; Mecamylamine; Morphine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Thiophenes | 2010 |
Effects of duloxetine treatment on brain response to painful stimulation in major depressive disorder.
Topics: Adult; Brain; Depressive Disorder, Major; Duloxetine Hydrochloride; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Pain; Pain Measurement; Thiophenes; Treatment Outcome | 2010 |
Evaluation of healthcare resource utilization and costs in employees with pain associated with diabetic peripheral neuropathy treated with pregabalin or duloxetine.
Topics: Adolescent; Adult; Age Factors; Analgesics; Comorbidity; Diabetic Neuropathies; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Health Services; Humans; Insurance Claim Review; Male; Middle Aged; Pain; Pregabalin; Sex Factors; Socioeconomic Factors; Thiophenes; Young Adult | 2010 |
[Effective treatment of depression. Early reduction of painful concomitant symptoms increases the probability of remission].
Topics: Antidepressive Agents; Depressive Disorder, Major; Duloxetine Hydrochloride; Early Diagnosis; General Practice; Humans; Pain; Quality of Life; Somatoform Disorders; Thiophenes | 2010 |
[Interview with Dr. Armin Spingler. Management of depression in family practice].
Topics: Antidepressive Agents; Depressive Disorder, Major; Duloxetine Hydrochloride; General Practice; Humans; Medication Adherence; Pain; Somatoform Disorders; Thiophenes | 2010 |
False conclusions regarding duloxetine's purported efficacy in pain among depressed patients.
Topics: Depressive Disorder, Major; Duloxetine Hydrochloride; Humans; Pain; Selective Serotonin Reuptake Inhibitors; Thiophenes; Treatment Outcome | 2010 |
Duloxetine use in painful conditions.
Topics: Analgesia; Analgesics; Animals; Antidepressive Agents; Chronic Disease; Disease Models, Animal; Duloxetine Hydrochloride; Humans; Low Back Pain; Osteoarthritis; Pain; Retrospective Studies; Thiophenes; Treatment Outcome | 2011 |
Treatment adherence and persistence with duloxetine, venlafaxine XR, and escitalopram among patients with major depressive disorder and chronic pain-related diseases.
Topics: Adolescent; Adult; Algorithms; Antidepressive Agents; Chronic Disease; Citalopram; Cyclohexanols; Depressive Disorder, Major; Dosage Forms; Duloxetine Hydrochloride; Female; Humans; Male; Medication Adherence; Middle Aged; Pain; Retrospective Studies; Somatoform Disorders; Thiophenes; Venlafaxine Hydrochloride; Young Adult | 2011 |
Factors associated with pain medication selection among patients diagnosed with diabetic peripheral neuropathic pain: a retrospective study.
Topics: Analgesics; Comorbidity; Costs and Cost Analysis; Diabetic Neuropathies; Duloxetine Hydrochloride; Female; Health Services; Humans; Insurance Claim Review; Male; Middle Aged; Pain; Retrospective Studies; Selective Serotonin Reuptake Inhibitors; Socioeconomic Factors; Thiophenes; United States | 2011 |
Predictors of pain medication selection among patients diagnosed with fibromyalgia.
Topics: Adult; Analgesics; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Cohort Studies; Duloxetine Hydrochloride; Female; Fibromyalgia; Humans; Male; Middle Aged; Pain; Predictive Value of Tests; Retrospective Studies; Selective Serotonin Reuptake Inhibitors; Thiophenes | 2012 |
Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.
Topics: Analgesics; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Hot Temperature; Humans; Hyperalgesia; Indoles; Ligation; Neuralgia; Nitric Oxide Synthase Type I; Pain; Pyridines; Spinal Nerves; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Vascular Resistance; Vasoconstriction | 2011 |
[Because depression also hurts: duloxetine can help patients return to vitality].
Topics: Antidepressive Agents; Depressive Disorder; Duloxetine Hydrochloride; Humans; Pain; Pain Measurement; Quality of Life; Somatoform Disorders; Thiophenes | 2011 |
Time course of improvement of different symptom clusters in patients with major depression and pain treated with duloxetine or placebo.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Male; Multicenter Studies as Topic; Pain; Pain Measurement; Placebos; Randomized Controlled Trials as Topic; Retrospective Studies; Severity of Illness Index; Thiophenes; Time Factors; Treatment Outcome | 2012 |
The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function.
Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxetine Hydrochloride; Exploratory Behavior; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Locomotion; Male; Morphine; Neuralgia; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes | 2012 |
Tolerability aspects in duloxetine-treated patients with depression: Should one use a lower starting dose in clinical practice?
Topics: Adult; Aged; Analgesics; Antidepressive Agents; Depression; Depressive Disorder, Major; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Drug Tolerance; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Pain; Precision Medicine; Prospective Studies; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index; Thiophenes | 2012 |
Association of candidate gene polymorphisms with diastolic blood pressure change in patients treated with duloxetine.
Topics: Adrenergic Uptake Inhibitors; Blood Pressure; Catechol O-Methyltransferase; Depressive Disorder, Major; Diastole; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Norepinephrine Plasma Membrane Transport Proteins; Pain; Polymorphism, Single Nucleotide; Receptors, Adrenergic, beta-2; Receptors, Dopamine; Receptors, Serotonin; Thiophenes | 2013 |
Analgesic effects of antidepressants.
Topics: Analgesics; Antidepressive Agents; Chronic Disease; Depressive Disorder; Duloxetine Hydrochloride; Evidence-Based Medicine; Humans; Pain; Review Literature as Topic; Thiophenes | 2003 |
A word of caution about the implied role for duloxetine in pain management.
Topics: Antidepressive Agents; Comorbidity; Depressive Disorder, Major; Duloxetine Hydrochloride; Humans; Pain; Pain Measurement; Somatoform Disorders; Thiophenes; Treatment Outcome | 2003 |
Repeated dosing with oral allosteric modulator of adenosine A1 receptor produces tolerance in rats with neuropathic pain.
Topics: Adenosine; Administration, Oral; Allosteric Regulation; Animals; Drug Tolerance; Male; Pain; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Spinal Nerves; Thiophenes; Xanthines | 2004 |
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats.
Topics: Acute Disease; Amines; Amitriptyline; Animals; Conscious Sedation; Cyclohexanecarboxylic Acids; Cyclohexanols; Cyclopropanes; Disease Models, Animal; Drug Therapy, Combination; Duloxetine Hydrochloride; Fluoxetine; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Male; Methyltyrosines; Milnacipran; Neuromuscular Junction; Norepinephrine; p-Chloroamphetamine; Pain; Paroxetine; Rats; Rats, Sprague-Dawley; Serotonin; Thiophenes; Venlafaxine Hydrochloride | 2004 |
Duloxetine's role in the treatment of depression and associated painful physical symptoms.
Topics: Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Diabetic Neuropathies; Duloxetine Hydrochloride; Humans; Pain; Pain Measurement; Thiophenes; Treatment Outcome | 2004 |
Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents.
Topics: Adrenergic Uptake Inhibitors; Amines; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Carrageenan; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Ibuprofen; Inflammation; Male; Mice; Morphine; Norepinephrine; Pain; Pain Measurement; Postural Balance; Rats; Rats, Sprague-Dawley; Reaction Time; Selective Serotonin Reuptake Inhibitors; Thiophenes | 2005 |
[Duloxetine reduces pain and depression].
Topics: Adrenergic Uptake Inhibitors; Analgesics; Antidepressive Agents; Depressive Disorder; Drug Approval; Duloxetine Hydrochloride; Germany; Humans; Pain; Selective Serotonin Reuptake Inhibitors; Thiophenes; Treatment Outcome; Urinary Incontinence, Stress | 2004 |
Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain.
Topics: Acute Disease; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Chronic Disease; Citalopram; Disease Models, Animal; Duloxetine Hydrochloride; Male; Mianserin; Mirtazapine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes | 2005 |
Duloxetine for the treatment of major depressive disorder in older patients.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Depressive Disorder, Major; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Pain; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Thiophenes; Treatment Outcome | 2005 |
Antinociceptive properties of acetylenic thiophene and furan derivatives: evidence for the mechanism of action.
Topics: Acetic Acid; Acetylene; Analgesics; Animals; Capsaicin; Dopamine Agents; Exploratory Behavior; Furans; Hot Temperature; Immersion; Male; Mice; Motor Activity; Muscarinic Antagonists; Muscle Contraction; Narcotic Antagonists; Pain; Pain Measurement; Pharmaceutical Solutions; Reaction Time; Receptors, Muscarinic; Thiophenes | 2005 |
Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents.
Topics: Acetic Acid; Adrenergic Uptake Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Drug Synergism; Duloxetine Hydrochloride; Hyperalgesia; Ibuprofen; Inflammation; Male; Mice; Mice, Inbred Strains; Norepinephrine; Pain; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Thiophenes | 2007 |
Duloxetine for childhood depression with pain and dissociative symptoms.
Topics: Antidepressive Agents; Benzodiazepines; Child; Depressive Disorder, Major; Dissociative Disorders; Duloxetine Hydrochloride; Female; Humans; Olanzapine; Pain; Thiophenes | 2006 |
[Physical complaints can overlap mental symptoms. Diffuse pain? Think about depression!].
Topics: Adrenergic Uptake Inhibitors; Antidepressive Agents; Depression; Diagnosis, Differential; Duloxetine Hydrochloride; Female; Humans; Male; Pain; Recurrence; Remission Induction; Selective Serotonin Reuptake Inhibitors; Thiophenes; Time Factors | 2006 |
[Duloxetin effective in depression and pain: high remission rates obtained].
Topics: Adrenergic Uptake Inhibitors; Antidepressive Agents; Clinical Trials as Topic; Depression; Dopamine Uptake Inhibitors; Duloxetine Hydrochloride; Humans; Pain; Pain Measurement; Placebos; Psychiatric Status Rating Scales; Remission Induction; Selective Serotonin Reuptake Inhibitors; Thiophenes; Time Factors | 2006 |
Does duloxetine safely and effectively reduce the severity of diabetic peripheral neuropathic pain?
Topics: Antidepressive Agents; Diabetic Neuropathies; Double-Blind Method; Duloxetine Hydrochloride; Humans; Multicenter Studies as Topic; Pain; Pain Measurement; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Thiophenes; Treatment Outcome | 2006 |
Cost-effectiveness of duloxetine versus routine treatment for U.S. patients with diabetic peripheral neuropathic pain.
Topics: Antidepressive Agents; Cost-Benefit Analysis; Diabetic Neuropathies; Drug Costs; Duloxetine Hydrochloride; Humans; Pain; Thiophenes | 2006 |
Duloxetine treatment of pediatric chronic pain and co-morbid major depressive disorder.
Topics: Abdominal Pain; Adolescent; Antidepressive Agents; Chronic Disease; Comorbidity; Crohn Disease; Depressive Disorder, Major; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Female; Humans; Low Back Pain; Pain; Sick Role; Thiophenes | 2007 |
Pregabalin and duloxetine for the treatment of neuropathic pain disorders.
Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Humans; Neuralgia; Pain; Pregabalin; Randomized Controlled Trials as Topic; Thiophenes | 2007 |
Pharmacological validation of a model of cystitis pain in the mouse.
Topics: Analgesics; Animals; Behavior, Animal; Cyclophosphamide; Cystitis; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Ketorolac; Male; Mice; Morphine; Pain; Pain Measurement; Thiophenes | 2007 |
The effects of pharmacological blockade of the 5-HT(6) receptor on formalin-evoked nociceptive behaviour, locomotor activity and hypothalamo-pituitary-adrenal axis activity in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Corticosterone; Defecation; Dose-Response Relationship, Drug; Formaldehyde; Grooming; Hypothalamo-Hypophyseal System; Injections, Intraperitoneal; Male; Motor Activity; Pain; Pain Measurement; Pituitary-Adrenal System; Radioimmunoassay; Rats; Receptors, Serotonin; Serotonin Antagonists; Stress, Physiological; Sulfonamides; Thiophenes; Time Factors | 2007 |
Duloxetine status.
Topics: Antidepressive Agents; Clinical Trials as Topic; Duloxetine Hydrochloride; Fibromyalgia; Humans; Pain; Thiophenes | 2007 |
Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives.
Topics: Analgesics; Animals; Antidepressive Agents; Depression; Drug Design; Drug Evaluation, Preclinical; Female; Hypnotics and Sedatives; Male; Mice; Molecular Structure; Motor Activity; Pain; Structure-Activity Relationship; Thiophenes | 2008 |
Synthesis and pharmacological evaluation of 2-substituted benzo[b]thiophenes as anti-inflammatory and analgesic agents.
Topics: Acetic Acid; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Carrageenan; Edema; Liver; Mice; Pain; Pain Threshold; Piroxicam; Rats; Stomach Ulcer; Structure-Activity Relationship; Thiophenes | 2009 |
Does pain mediate the pain interference with sleep problem in chronic pain? Findings from studies for management of diabetic peripheral neuropathic pain with duloxetine.
Topics: Antidepressive Agents; Chronic Disease; Comorbidity; Diabetic Neuropathies; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Incidence; Male; Middle Aged; Pain; Randomized Controlled Trials as Topic; Sleep Initiation and Maintenance Disorders; Thiophenes; Treatment Outcome; United States | 2008 |
Further evidence that substance P is a mediator of both neurogenic inflammation and pain: two phenomena inhibited either by postsynaptic blockade of NK1 receptors or by presynaptic action of opioid receptor agonists.
Topics: Analgesics; Animals; Anticonvulsants; Electric Stimulation; Formaldehyde; Indoles; Inflammation; Isoindoles; Male; Mice; Mice, Inbred Strains; Morphine; Pain; Peripheral Nerves; Pyrroles; Rats; Rats, Sprague-Dawley; Substance P; Thiophenes | 1993 |
Effect of fedotozine on the cardiovascular pain reflex induced by distension of the irritated colon in the anesthetized rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetates; Acetic Acid; Amino Acid Sequence; Anesthesia; Animals; Benzyl Compounds; Blood Pressure; Colon; Dose-Response Relationship, Drug; Male; Molecular Sequence Data; Pain; Propylamines; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reflex; Thiophenes | 1994 |
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Benzofurans; Benzomorphans; Cyclazocine; Fentanyl; Gastric Emptying; Intestinal Pseudo-Obstruction; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peritoneum; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1997 |
Glaucomatocyclitic crisis in a child.
Topics: Adolescent; Clonidine; Corneal Edema; Diagnosis, Differential; Drug Therapy, Combination; Glaucoma; Humans; Intraocular Pressure; Male; Pain; Prednisolone; Sulfonamides; Syndrome; Thiophenes; Timolol; Uveitis, Intermediate; Vision Disorders; Visual Acuity | 1998 |
Involvement of a peripheral component in the antinociceptive effects of opioids in a model of tonic pain.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Male; Morphine; Narcotics; Pain; Peripheral Nerves; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1990 |
[Thiophene as a structural element of physiologically active compounds. 19. The synthesis of substituted (6H-thieno[2,3-b]pyrrol-4-yl)phenylmethanones].
Topics: Analgesics; Animals; Indoles; Mice; Morphine; Morpholines; Pain; Rats; Thiophenes | 1991 |
Standardization of the rat paw formalin test for the evaluation of analgesics.
Topics: Analgesics; Animals; Aspirin; Behavior, Animal; Decerebrate State; Foot; Formaldehyde; Male; Morphine; Pain; Pyrroles; Rats; Rats, Inbred Strains; Reference Standards; Thiophenes | 1991 |
Comparison of PD 117302, a kappa agonist, and morphine on colonic transit and formalin-induced pain in rats.
Topics: Animals; Colon; Dose-Response Relationship, Drug; Formaldehyde; Gastrointestinal Transit; Male; Morphine; Pain; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes | 1989 |
Pizotifen in deafferentation pain.
Topics: Afferent Pathways; Aged; Aged, 80 and over; Female; Hemiplegia; Humans; Intracranial Embolism and Thrombosis; Male; Movement Disorders; Pain; Pizotyline; Syndrome; Thalamic Diseases; Thiophenes | 1989 |
Pharmacological profile of PD 117302, a selective kappa-opioid agonist.
Topics: Analgesics; Animals; Depression, Chemical; Diuretics; Gastrointestinal Motility; Injections, Intravenous; Male; Mice; Pain; Pyrroles; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Respiration; Substance-Related Disorders; Thiophenes | 1987 |
Anti-nociceptive activity of some thiophthalanes with morphine-like properties.
Topics: Analgesia; Analgesics; Animals; Bridged-Ring Compounds; Depression, Chemical; Dextropropoxyphene; Dimethylamines; Electric Stimulation; Ketones; Male; Meperidine; Methadone; Mice; Morphine; Pain; Piperidines; Thiophenes | 1973 |
[Anti-inflammatory and anti-arthritic properties of (5-chloro-3-methylbenzo (b) thien-2-yl)acetic acid].
Topics: Acetates; Adrenal Glands; Adrenalectomy; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Bradykinin; Carrageenan; Edema; Electroshock; Erythema; Fever; Freund's Adjuvant; Guinea Pigs; Hot Temperature; Mice; Mice, Inbred Strains; Pain; Pleural Effusion; Rats; Silver Nitrate; Thiophenes; Ultraviolet Rays; Wounds and Injuries | 1974 |
Nitrolglycerin as a provocative agent in cluster headache.
Topics: Adult; Blood Pressure; Headache; Humans; Male; Middle Aged; Nitroglycerin; Pain; Parasympatholytics; Pulse; Thiophenes; Time Factors | 1968 |
Seminar on headache.
Topics: Benzocycloheptenes; Diagnosis, Differential; Ergotamine; Headache; Humans; Methysergide; Migraine Disorders; Pain; Piperidines; Thiophenes | 1971 |
[Studies on anti-inflammatory agents. I. Some biological activities of thienopyridine derivatives].
Topics: Administration, Oral; Aminopyrine; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Male; Mice; Pain; Phenylbutazone; Pyridines; Rats; Salicylates; Sulfhydryl Compounds; Thiophenes | 1970 |
[Studies on anti-inflammatory agents. IV. On the appearance of physical dependence and analgesic activity of 2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6-7-tetrahydrothieno(2,3-c)pyridine (Y-3642) by repeated administration].
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Body Weight; Diet; Drug Tolerance; Humans; Injections, Intraperitoneal; Injections, Subcutaneous; Levallorphan; Male; Morphine; Pain; Pyridines; Rats; Substance-Related Disorders; Sulfhydryl Compounds; Thiophenes; Water | 1970 |
[Studies on anti-inflammatory agents. II. Analgesic and anti-edematous activities of 2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6, 7-tetrahydrothieno (2,3-c)pyridine (Y-3642)].
Topics: Aminopyrine; Amphetamine; Analgesics; Animals; Anti-Inflammatory Agents; Edema; Imipramine; Male; Mice; Morphine; Pain; Papaverine; Phenylbutazone; Pyridines; Rats; Salicylates; Thiophenes | 1970 |