Page last updated: 2024-11-05

thalidomide and HIV

thalidomide has been researched along with HIV in 4 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.

Research Excerpts

ExcerptRelevanceReference
"Thalidomide (400 mg) was orally administered to 6 men, and their blood was stimulated ex vivo with LPS, staphylococcal or mycobacterial antigens, or antibody to CD3 or CD28 cells."1.31Thalidomide suppresses Up-regulation of human immunodeficiency virus coreceptors CXCR4 and CCR5 on CD4+ T cells in humans. ( Juffermans, NP; Olszyna, DP; Speelman, P; van Der Poll, T; van Deventer, SJ; Verbon, A, 2000)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Liu, P1
Pei, N1
Liu, X1
Huang, W1
Lu, S1
Agrawal, S1
Deshpande, A1
Wolday, D1
Akuffo, H1
Demissie, A1
Britton, S1
Juffermans, NP1
Verbon, A1
Olszyna, DP1
van Deventer, SJ1
Speelman, P1
van Der Poll, T1

Other Studies

4 other studies available for thalidomide and HIV

ArticleYear
Thalidomide in the treatment of human immunodeficiency virus-negative tuberculous meningitis: A case report.
    Medicine, 2020, Oct-02, Volume: 99, Issue:40

    Topics: Adrenal Cortex Hormones; Adult; Antitubercular Agents; Asian People; Brain; Drug Therapy, Combinatio

2020
A unique presentation of multiple myeloma in an HIV patient.
    The Indian journal of medical research, 2013, Volume: 137, Issue:4

    Topics: Aged; HIV; HIV Infections; HIV Seropositivity; Humans; Male; Multiple Myeloma; Radiography; Thalidom

2013
Role of Leishmania donovani and its lipophosphoglycan in CD4+ T-cell activation-induced human immunodeficiency virus replication.
    Infection and immunity, 1999, Volume: 67, Issue:10

    Topics: Adult; Animals; Antigens, Protozoan; Apoptosis; CD4-Positive T-Lymphocytes; Cytokines; Glycosphingol

1999
Thalidomide suppresses Up-regulation of human immunodeficiency virus coreceptors CXCR4 and CCR5 on CD4+ T cells in humans.
    The Journal of infectious diseases, 2000, Volume: 181, Issue:5

    Topics: Adult; CD4-Positive T-Lymphocytes; Cells, Cultured; HIV; Humans; Kinetics; Lipopolysaccharides; Male

2000