thalidomide has been researched along with Coma in 3 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Childhood tuberculous meningitis is associated with serious long-term sequelae, including mental retardation, behavior disturbances, and motor handicap." | 2.71 | Adjunctive thalidomide therapy for childhood tuberculous meningitis: results of a randomized study. ( Hanekom, WA; Haslett, PA; Kaplan, G; Schoeman, JF; Springer, P; Swanevelder, S; van Rensburg, AJ, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tannemaat, MR | 1 |
| Vries, EP | 1 |
| Molendijk, WJ | 1 |
| Haan, J | 1 |
| do Prado, AD | 1 |
| Schmoeller, D | 1 |
| Bisi, MC | 1 |
| Piovesan, DM | 1 |
| Dias, FS | 1 |
| Staub, HL | 1 |
| Schoeman, JF | 1 |
| Springer, P | 1 |
| van Rensburg, AJ | 1 |
| Swanevelder, S | 1 |
| Hanekom, WA | 1 |
| Haslett, PA | 1 |
| Kaplan, G | 1 |
1 trial available for thalidomide and Coma
| Article | Year |
|---|---|
Adjunctive thalidomide therapy for childhood tuberculous meningitis: results of a randomized study.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antitubercular Agents; Chemotherapy, Adjuvant; Ch | 2004 |
2 other studies available for thalidomide and Coma
| Article | Year |
|---|---|
Fatal ischemic stroke in a patient receiving lenalidomide for multiple myeloma.
Topics: Anticoagulants; Antineoplastic Agents; Coma; Fatal Outcome; Female; Heparin, Low-Molecular-Weight; H | 2011 |
Scleromyxedema with monoclonal gammopathy and neurological involvement: recovery from coma after plasmapheresis?
Topics: Brain Diseases; Coma; Humans; Immunosuppressive Agents; Male; Melphalan; Middle Aged; Myeloablative | 2012 |