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thalidomide and Asthma

thalidomide has been researched along with Asthma in 6 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

ExcerptRelevanceReference
"This study is designed to determine the effect and the potential mechanism of thalidomide in the pathogenesis of asthmatic airways using animal model of allergic asthma."7.81Thalidomide inhibits alternative activation of macrophages in vivo and in vitro: a potential mechanism of anti-asthmatic effect of thalidomide. ( Chang, YS; Cho, SH; Kang, HR; Kim, HR; Kim, HY; Kwon, HS; Lee, HS; Min, KU; Park, DE; Woo, YD, 2015)
"When thalidomide was administered to OVA-challenged mice, the number of eosinophils in bronchoalveolar lavage fluid (BALF) was significantly decreased."5.36Thalidomide attenuates airway hyperresponsiveness and eosinophilic inflammation in a murine model of allergic asthma. ( Asano, T; Hasegawa, Y; Ito, S; Kume, H; Taki, F, 2010)
" The efficacy and safety evaluations of several PDE4 inhibitors are currently carried on in clinical trials, for example GSK256066 in asthma, roflumilast and GSK256066 in chronic obstructive pulmonary disease, tetomilast in inflammatory bowel disease, and apremilast in dermatitis and arthritis etc."4.90[Progress in PDE4 targeted therapy for inflammatory diseases]. ( Song, SD; Tang, HF, 2014)
"This study is designed to determine the effect and the potential mechanism of thalidomide in the pathogenesis of asthmatic airways using animal model of allergic asthma."3.81Thalidomide inhibits alternative activation of macrophages in vivo and in vitro: a potential mechanism of anti-asthmatic effect of thalidomide. ( Chang, YS; Cho, SH; Kang, HR; Kim, HR; Kim, HY; Kwon, HS; Lee, HS; Min, KU; Park, DE; Woo, YD, 2015)
"When thalidomide was administered to OVA-challenged mice, the number of eosinophils in bronchoalveolar lavage fluid (BALF) was significantly decreased."1.36Thalidomide attenuates airway hyperresponsiveness and eosinophilic inflammation in a murine model of allergic asthma. ( Asano, T; Hasegawa, Y; Ito, S; Kume, H; Taki, F, 2010)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kodimuthali, A1
Jabaris, SS1
Pal, M1
Ghaderi, M1
Oryan, S1
Yousofvand, N1
Eidi, A1
Song, SD1
Tang, HF1
Lee, HS1
Kwon, HS1
Park, DE1
Woo, YD1
Kim, HY1
Kim, HR1
Cho, SH1
Min, KU1
Kang, HR1
Chang, YS1
Asano, T1
Kume, H1
Taki, F1
Ito, S1
Hasegawa, Y1
Braddock, M1
Murray, C1

Reviews

2 reviews available for thalidomide and Asthma

ArticleYear
Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.
    Journal of medicinal chemistry, 2008, Sep-25, Volume: 51, Issue:18

    Topics: Asthma; Humans; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Disease, Chr

2008
[Progress in PDE4 targeted therapy for inflammatory diseases].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2014, Volume: 43, Issue:3

    Topics: Aminopyridines; Aminoquinolines; Arthritis; Asthma; Benzamides; Cyclopropanes; Dermatitis; Humans; I

2014

Other Studies

4 other studies available for thalidomide and Asthma

ArticleYear
Inhibition of Airway Contraction and Inflammation by Pomalidomide in a Male Wistar Rat Model of Ovalbumin-induced Asthma.
    Iranian journal of allergy, asthma, and immunology, 2019, Apr-01, Volume: 18, Issue:2

    Topics: Airway Obstruction; Allergens; Animals; Anti-Inflammatory Agents; Asthma; Disease Models, Animal; Hu

2019
Thalidomide inhibits alternative activation of macrophages in vivo and in vitro: a potential mechanism of anti-asthmatic effect of thalidomide.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Allergens; Alum Compounds; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchi

2015
Thalidomide attenuates airway hyperresponsiveness and eosinophilic inflammation in a murine model of allergic asthma.
    Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid;

2010
10th anniversary Inflammation and Immune Diseases Drug Discovery and Development Summit. 20-21 March 2006, New Brunswick, USA.
    Expert opinion on investigational drugs, 2006, Volume: 15, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Clinical Trials as Topic; Drug Delivery Systems; Drug Des

2006