tetracycline and Ulcer

An unusual case is described of extragenital Mycoplasma hominis infection presenting as a septic arthritis of the hip joint in a young paraplegic girl. The few reported cases of M. hominis septic arthritis are summarized. Based on the current case and these reported cases, the etiology, presentation, diagnosis, and treatment of this infection are discussed.

Topics: Arthritis, Infectious; Child; Diagnosis, Differential; Female; Groin; Hip Joint; Humans; Mycoplasma Infections; Paraplegia; Tetracycline; Ulcer

Topics: Adolescent; Adult; Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Cross-Sectional Studies; Drug Resistance, Microbial; Duodenal Ulcer; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Metronidazole; Microbial Sensitivity Tests; Middle Aged; Peptic Ulcer; Tetracycline; Ulcer

To report the presence of an asymptomatic cilium in the subconjunctival area and an adjacent sterile scleral ulcer, together as a complication of subtenon injection of steroids, and the resolution of the ulcer despite the in situ cilium.. Medical management of a 51-year-old man, who was a known case of ankylosing spondylitis, with a 3-mm scleral ulcer located in the inferior palpebral area with one adjacent fully embedded cilium at the probable site of subtenon injection given for suspected acute iridocyclitis.. On altering the medication, the ulcer resolved completely. This occurred despite the in situ cilium, which did not act as a nidus for infection or inflammation.. The presence of cilia did not adversely affect the outcome of treatment of the adjacent ulcer. Therefore, if there is no exposure of the entrapped cilium through the conjunctiva, as was in this case, conservative management of the ulcer and not trying to remove the cilium seems to be a good alternative as opposed to reports in literature, which warrant its removal in most cases.

Topics: Anti-Bacterial Agents; Ascorbic Acid; Carboxymethylcellulose Sodium; Chloramphenicol; Cilia; Conjunctival Diseases; Drug Therapy, Combination; Eye Foreign Bodies; Humans; Iatrogenic Disease; Injections, Intraocular; Iridocyclitis; Male; Middle Aged; Scleral Diseases; Spondylitis, Ankylosing; Steroids; Tetracycline; Ulcer; Vitamins

Topics: Anti-Bacterial Agents; Chlamydia trachomatis; Doxycycline; Erythromycin; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Lymphogranuloma Venereum; Male; Pregnancy; Pregnancy Complications, Infectious; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination; Ulcer

Topics: Adult; Humans; Male; Mouth Diseases; Mouth Mucosa; Tetracycline; Ulcer

Acne fulminans is an ulcerative form of acne with an acute onset and systemic symptoms. It most commonly affects adolescent boys.. Clinical and laboratory findings and treatment results of patients with acne fulminans were reviewed to obtain a better understanding of the clinical course and outcome of the disease.. Data of patients with severe acne were collected from the Dermatology Departments of Finnish hospitals during the years 1970 to 1991.. Twenty-four patients with acne fulminans are described. All patients had ulcerative acne with acute onset. In 22 patients acne was associated with high fever for at least 1 week. All patients had musculoskeletal pain. Increased uptake in bone scan or radiographic findings compatible with an infectious origin were detected in 17 patients. Eight patients were treated with antibiotics alone, but the response was poor; three patients had a relapse of musculoskeletal symptoms. Ten patients were given systemic steroids in addition to antibiotics. In this group the response was rapid, but acne and musculoskeletal symptoms tended to relapse when the steroid dosage was reduced. Four patients were treated with a combination of antibiotics, systemic steroids, and isotretinoin; all responded well, but one of these patients also had a relapse.. Musculoskeletal symptoms are common in patients with acne fulminans. Systemic steroid treatment rapidly controls the skin lesions and systemic symptoms. The duration of steroid treatment should be 2 to 4 months to avoid relapses. Therapy with isotretinoin, antibiotics, or both was often combined with steroids, but the role of these agents is still uncertain.

Topics: Acne Vulgaris; Adolescent; Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Blood Sedimentation; Dermatitis, Atopic; Female; Fever; Glucocorticoids; Humans; Isotretinoin; Joints; Leukocytosis; Male; Muscles; Osteolysis; Pain; Retrospective Studies; Tetracycline; Ulcer

We describe nine cases of esophageal injury associated with the ingestion of prescribed medications. Antibiotics were the most commonly implicated drugs. Odynophagia, retrosternal chest pain and dysphagia were the usual presenting symptoms. The typical endoscopic finding was that of discrete ulcers in the mid-esophagus. All patients recovered uneventfully with discontinuation of the offending drug and symptomatic treatment. Drug induced esophageal injury should be considered in patients presenting acutely with the above mentioned symptoms and having discrete esophageal ulcers on endoscopy.

Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Chest Pain; Deglutition Disorders; Drug Prescriptions; Esophageal Diseases; Female; Humans; Male; Middle Aged; Tablets; Tetracycline; Ulcer

To determine the clinical characteristics, possible etiologic agents, and response to oral antibiotic therapy in patients with phlyctenular keratoconjunctivitis.. The authors reviewed the medical records of the 17 patients with phlyctenular keratoconjunctivitis who were seen and treated at the Bascom Palmer Eye Institute between 1981 and 1991.. All 17 patients were younger than 18 years of age at the onset of their disease. Girls (n = 14) outnumbered boys (n = 3) 4:1. Significant incapacitating symptoms and ocular morbidity occurred frequently, including three perforated corneas. Five of ten patients who were tested for Chlamydia infection had positive test results and five patients possibly had early rosacea dermatitis. All patients experienced long-term remission of their ocular disease after a course of oral tetracycline or erythromycin. Two patients demonstrated unique linear (fascicular) corneal phlyctenules.. Oral tetracycline or erythromycin treatment produces long-lasting remission of phlyctenular keratoconjunctivitis in affected children.

Topics: Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Chlamydia Infections; Erythromycin; Female; Follow-Up Studies; Humans; Keratoconjunctivitis; Male; Rosacea; Tetracycline; Treatment Outcome; Ulcer

Ulcerative esophagitis may be caused by corrosive agents and by commonly prescribed medications. We report severe esophagitis in five adolescents after ingestion of tetracycline preparations with minimal water immediately before going to bed.

Topics: Adolescent; Adult; Doxycycline; Esophagitis; Female; Humans; Male; Tetracycline; Ulcer

Topics: Acantholysis; Adolescent; Adult; Betamethasone; Colitis, Ulcerative; Female; Ferrous Compounds; Humans; Male; Stomatitis; Sulfasalazine; Tetracycline; Ulcer

Topics: Doxycycline; Esophageal Diseases; Humans; Tetracycline; Ulcer

Clinical, radiographic, and endoscopic features of medication-induced esophagitis (MIE) in 4 patients are described. When the clinical history and symptoms raise a high index of suspicion for MIE, a double-contrast esophagram or endoscopic examination should be performed. The proximal esophagus, particularly the aortic segment, and occasionally the distal esophagus are the sites most commonly affected by MIE. Superficial mucosal erosions, shallow ulcers, and subtle mucosal alterations can be demonstrated by double-contrast esophagrams if careful attention is paid during performance and interpretation of these studies in an appropriate clinical setting.

Topics: Adult; Doxycycline; Esophagitis; Esophagus; Female; Humans; Ibuprofen; Male; Middle Aged; Radiography; Tetracycline; Ulcer

Topics: Adult; Capsules; Esophageal Diseases; Humans; Male; Tetracycline; Ulcer

Patients with esophageal symptoms following drug ingestion underwent double-contrast upper gastrointestinal studies, and radiographic findings are described. Superficial esophageal ulceration and subtle mucosal abnormalities, which have not been seen on single-contrast radiographs, were confirmed on double-contrast radiographs. Erosions or ulcers usually occur in the region of the aortic arch and occasionally lower in the esophagus. Repeat esophagrams after withdrawal of the medication indicate resolution of the symptoms.

Topics: Adult; Barium Sulfate; Doxycycline; Esophagitis; Esophagus; Female; Humans; Male; Middle Aged; Quinidine; Radiography; Tetracycline; Ulcer

Topics: Adult; Capsules; Esophageal Diseases; Humans; Male; Tetracycline; Ulcer

Topics: Adult; Esophageal Diseases; Humans; Male; Tablets; Tetracycline; Ulcer

Of 97 patients with genital ulcers attending a special treatment clinic in Nairobi, Kenya, 60 harboured Haemophilus ducreyi, four herpes simplex virus, and five Neisseria gonorrhoeae. Eleven patients had serological evidence of syphilis; of these one case was confirmed by darkfield microscopy. In the remaining cases no aetiological agent was identified. An enriched chocolate agar with vancomycin and serum was a useful medium for primary isolation of H ducreyi. Tetracycline was generally ineffective in the treatment of ulcers, but sulfadimidine was successful in almost 80% of cases.

Topics: Adult; Chancroid; Female; Genital Diseases, Male; Haemophilus ducreyi; Humans; Kenya; Male; Neisseria gonorrhoeae; Sulfamethazine; Tetracycline; Ulcer

Topics: Doxycycline; Esophageal Diseases; Humans; Tetracycline; Ulcer

Two cases of tetracycline ulcers of the oesophagus are reported and compared with thirteen other cases from the literature. In most cases, the patients had taken their capsules with little or no fluid just before going to bed. Some hours later they developed retrosternal pain that was intensified by swallowing. Endoscopy showed sharply demarcated greyish-white areas of mucosal damage which represented layers of stratified squamous cells, separated by oedema, and a dense neutrophilic infiltration of the lamina propria and the muscularis mucosa. Roentgenology was unsuitable to detect the lesions. They healed without complications within one to six weeks. Prolonged retention of the capsules in the oesophagus is thought to cause the mucosal damage. Patients on oral tetracycline or doxycyline treatment should therefore be instructed to take their capsules with a meal or with copious water and not just before going to bed.

Topics: Aged; Esophageal Diseases; Esophagoscopy; Female; Humans; Middle Aged; Tetracycline; Ulcer

Delayed passage of irritant drugs like tetracycline hydrochloride can cause esophageal ulceration, especially when the medication is taken with only a sip of water before sleeping or by a patient with stricture or motor abnormality of the esophagus. Certain precautions should be taken when prescribing irritant drugs. Patients should be advised to take sufficient quantities of water with the medication and to avoid taking the capsules at bedtime. These drugs should not be given to patients with esophageal obstruction or motility disorders.

Topics: Acne Vulgaris; Adolescent; Adult; Esophageal Diseases; Female; Humans; Male; Skin Diseases; Tetracycline; Ulcer

Topics: Adolescent; Esophagitis; Humans; Tetracycline; Ulcer

Two cases of acute vulvar ulcer of Lipschuetz are reported. The present state of knowledge as to the etiology, signs and symptoms, clinical course and treatment of this rare and frequently misdiagnosed entity are discussed.

Topics: Acute Disease; Adolescent; Ampicillin; Female; Humans; Tetracycline; Ulcer; Vulvar Diseases

Topics: Adult; Endoscopy; Esophageal Diseases; Humans; Male; Tetracycline; Ulcer

Topics: Adult; Aminopyrine; Dipyrone; Esophageal Diseases; Female; Humans; Male; Middle Aged; Oxytetracycline; Penicillin V; Tetracycline; Ulcer

Topics: Adult; Capsules; Esophagus; Humans; Tetracycline; Ulcer

Topics: Adult; Esophageal Diseases; Female; Humans; Tetracycline; Ulcer

Topics: Acids; Doxycycline; Esophageal Diseases; Humans; Tetracycline; Ulcer

Esophageal ulceration has rarely been reported secondary to medicinal agents. we have treated three patients with esophageal ulceration associated with the ingestion of tetracycline or its derivative doxycycline. In light of the strong temporal relationship between taking the capsules and the onset of the esophageal ulceration, we believe that the capsules were the cause of the ulcers. We therefore recommend an alternative agent to tetracycline or doxycycline, if possible, for patients with any esophageal obstructive element. We also recommend that patients be cautioned not to take these drugs within one hour of going to bed.

Topics: Acne Vulgaris; Adult; Antacids; Doxycycline; Esophageal Diseases; Female; Humans; Tetracycline; Ulcer; Urinary Tract Infections

Topics: Esophageal Diseases; Humans; Hydrogen-Ion Concentration; Solutions; Tetracycline; Ulcer

Topics: Administration, Topical; Adolescent; Anti-Inflammatory Agents; Barium Sulfate; Biopsy; Crohn Disease; Epithelium; Humans; Hydrocortisone; Male; Mouth Diseases; Mouth Mucosa; Mouthwashes; Nystatin; Oral Manifestations; Physical Examination; Prednisone; Radiography; Sulfasalazine; Tetracycline; Ulcer

Topics: Bacteriological Techniques; Endocarditis, Bacterial; Female; Humans; Middle Aged; Penicillin G; Salmonella; Salmonella Infections; Sepsis; Species Specificity; Tetracycline; Ulcer

Topics: Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Chloramphenicol; Chlortetracycline; Dyspepsia; Endometritis; Erythromycin; Erythromycin Ethylsuccinate; Female; Glucose Oxidase; Humans; Microbial Sensitivity Tests; Neomycin; Oleandomycin; Oxytetracycline; Parametritis; Penicillin Resistance; Penicillins; Plants, Medicinal; Proteus; Proteus mirabilis; Proteus vulgaris; Streptomycin; Tetracycline; Ulcer; Wound Infection

Topics: Adult; Aged; Animals; Bites and Stings; Child; Child, Preschool; Chloramphenicol; Disease Reservoirs; Erythromycin; Female; Humans; Lung Diseases; Male; Middle Aged; Osteomyelitis; Pasteurella Infections; Penicillin G; Penicillin V; Penicillins; Tetracycline; Ulcer; Wound Infection; Zoonoses

Topics: Adolescent; Adult; Female; Herpes Labialis; Herpesviridae Infections; Humans; Male; Stomatitis, Aphthous; Tetracycline; Tongue Diseases; Ulcer

Topics: Avitaminosis; Carcinoma, Squamous Cell; Denture, Complete; Gingival Diseases; Hematologic Diseases; Humans; Male; Middle Aged; Mouth Neoplasms; Poisoning; Stomatitis, Aphthous; Tetracycline; Ulcer

Topics: Child; Colon; Enteritis; Humans; Ileitis; Ileum; Intestinal Mucosa; Intestinal Perforation; Intussusception; Male; Postoperative Complications; Tetracycline; Ulcer

Topics: Anti-Bacterial Agents; Chloramphenicol; Colistin; Cornea; Corneal Transplantation; Debridement; Diathermy; Eye Burns; Eye Injuries; Geriatrics; Humans; Injections, Intra-Arterial; Iontophoresis; Lidocaine; Ophthalmology; Polymyxins; Pseudomonas Infections; Staphylococcal Infections; Streptomycin; Tetracycline; Therapeutic Irrigation; Ulcer

Topics: Anti-Bacterial Agents; Cortisone; Endoscopy; Gastrostomy; Humans; Otolaryngology; Penicillins; Pharynx; Prednisolone; Stomach; Surgical Procedures, Operative; Tetracycline; Ulcer

Topics: Anti-Bacterial Agents; Biomedical Research; Diagnosis, Differential; Fluorescence; Humans; Stomach Neoplasms; Stomach Ulcer; Tetracycline; Ulcer

Topics: Anti-Bacterial Agents; Fractures, Bone; Gangrene; Hospitals, General; Injections, Intravenous; Orthopedics; Osteomyelitis; Rolitetracycline; Tetracycline; Toxicology; Ulcer; Wounds and Injuries

Topics: Anti-Bacterial Agents; Fluorescence; Humans; Neoplasms; Protein Synthesis Inhibitors; Tetracycline; Ulcer

Topics: Anti-Bacterial Agents; Fluorescence; Protein Synthesis Inhibitors; Tetracycline; Ulcer; Wound Healing; Wounds and Injuries

Topics: Animals; Anti-Bacterial Agents; Chondroitin; Dogs; Stomach; Stomach Diseases; Sulfates; Tetracycline; Ulcer