tetracycline and Edema

Topics: Anti-Inflammatory Agents; Bromelains; Clinical Trials as Topic; Drug Combinations; Edema; Female; Genital Diseases, Female; Hematoma; Humans; Intestinal Mucosa; Male; Phlebitis; Surgical Wound Infection; Tetracycline; Wounds and Injuries

Topics: Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Edema; Female; Humans; Inflammation; Male; Middle Aged; Pyrazoles; Surgery, Oral; Tetracycline

A series of novel fluorine-containing lupane triterpenoid acid derivatives with fluoroaromatic amide moieties at the C-28 position (1-8) or with 2-(fluoroacyl)cyclopentane-1,3-dione fragments at the C-3 position (9-18) of lupane skeleton was synthesized. A simple synthesis of novel lupane triterpenoid hybrids with 2-(fluoroacyl)-2-cyclopenten-1-one moieties was developed. An interaction of 2-acyl-3-chlorocyclopent-2-en-1-ones, obtained from corresponding cyclic β-triketones, with methyl 3-amino-3-deoxybetulinate gave 3β-isomers (9-13) and 3α-isomers (14-18) of target hybrids, which were isolated as individual compounds. Anti-inflammatory properties of selected synthesized compounds were studied in vivo using the histamine-, concanavalin A- and sheep erythrocytes immunization-induced mouse paw edema models. The antioxidant activity was investigated in vivo on the model of tetracycline-induced hepatitis. Majority of synthesized fluorine-containing lupane triterpenoid acid derivatives exhibited significant anti-inflammatory and antioxidant effects. Among studied compounds, 3β-hybrid 11 with 2-perfluorobutanoyl-2-cyclopenten-1-one moiety was the most potent bioactive compound.

Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Betulinic Acid; Concanavalin A; Disease Models, Animal; Drug Design; Edema; Female; Fluorine; Hepatitis; Histamine; Male; Mice; Mice, Inbred C57BL; Molecular Conformation; Pentacyclic Triterpenes; Tetracycline; Triterpenes

In the present study, an efficient synthesis of some new substituted pyrazoline derivatives linked to a substituted pyrazole scaffold was performed by a multistep reaction sequences and compounds were screened for their anti-inflammatory, analgesic and antibacterial activities. The preliminary results revealed that the N-acylated (5e, 5h) and nitro substituted N-phenyl (6f) pyrazolyl-pyrazolines derivatives exhibited a very promising anti-inflammatory activity whereas 5h, 6f were interesting analgesic agents. The compounds with halo substituted phenyl group at C-3 of the pyrazoline ring (4a, 5g, 5h, 6a and 6b) were found to be active against clinical bacterial pathogens with MIC in the range of 0.2-0.4 mg/mL. Compound containing N-propionyl pyrazolyl-pyrazoline (5h) could be identified as the most active member within this study with a dual anti-inflammatory and antibacterial profile. Taken together, this study has led to the development of promising compounds.

Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacteria; Carrageenan; Dose-Response Relationship, Drug; Drug Design; Edema; Male; Mice; Microbial Sensitivity Tests; Molecular Structure; Pyrazoles; Rats; Rats, Wistar; Structure-Activity Relationship

Cardiovascular toxicity is a major challenge for the pharmaceutical industry and predictive screening models to identify and eliminate pharmaceuticals with the potential to cause cardiovascular toxicity in humans are urgently needed. In this study, taking advantage of the transparency of larval zebrafish, Danio rerio, we assessed cardiovascular toxicity of seven known human cardiotoxic drugs (aspirin, clomipramine hydrochloride, cyclophosphamide, nimodipine, quinidine, terfenadine and verapamil hydrochloride) and two non-cardiovascular toxicity drugs (gentamicin sulphate and tetracycline hydrochloride) in zebrafish using six specific phenotypic endpoints: heart rate, heart rhythm, pericardial edema, circulation, hemorrhage and thrombosis. All the tested drugs were delivered into zebrafish by direct soaking and yolk sac microinjection, respectively, and cardiovascular toxicity was quantitatively or qualitatively assessed at 4 and 24 h post drug treatment. The results showed that aspirin accelerated the zebrafish heart rate (tachycardia), whereas clomipramine hydrochloride, cyclophosphamide, nimodipine, quinidine, terfenadine and verapamil hydrochloride induced bradycardia. Quinidine and terfenadine also caused atrioventricular (AV) block. Nimodipine treatment resulted in atrial arrest with much slower but regular ventricular heart beating. All the tested human cardiotoxic drugs also induced pericardial edema and circulatory disturbance in zebrafish. There was no sign of cardiovascular toxicity in zebrafish treated with non-cardiotoxic drugs gentamicin sulphate and tetracycline hydrochloride. The overall prediction success rate for cardiotoxic drugs and non-cardiotoxic drugs in zebrafish were 100% (9/9) as compared with human results, suggesting that zebrafish is an excellent animal model for rapid in vivo cardiovascular toxicity screening. The procedures we developed in this report for assessing cardiovascular toxicity in zebrafish were suitable for drugs delivered by either soaking or microinjection.

Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cardiotoxins; Clomipramine; Cyclophosphamide; Disease Models, Animal; Edema; Gentamicins; Heart Diseases; Heart Rate; Heart Ventricles; Larva; Microinjections; Nimodipine; Pericardium; Quinidine; Terfenadine; Tetracycline; Toxicity Tests; Verapamil; Yolk Sac; Zebrafish

We report a symptomatic girl with reversible circumscribed cytotoxic oedema in the splenium of the corpus callosum (CC) that occurred, to our knowledge, for the first time in relation to tetracycline treatment. After stopping tetracycline therapy the girl recovered completely and the CC lesion, clearly visible on diffusion-weighted MR imaging (DWI), disappeared. Reversible circumscribed cytotoxic oedema (CCO) of the splenium of the CC is a well-defined entity that is found to be associated with administration of antiepileptic drugs, alterations in therapy using arginin-vasopressin and metronidazole or infections with influenza and rotavirus. CCO of splenium of the CC is clearly visible on DWI, shows no enhancement after administration of contrast medium and is completely reversible in most cases.

Topics: Adolescent; Corpus Callosum; Edema; Female; Folliculitis; Humans; Magnetic Resonance Imaging; Tetracycline

This report describes two cases of palpebral localisation of Tunga penetrans.. Two Congolese patients (a 17-year-old black man and a 12-year-old black girl) presented with a history of itching and oedema of the left upper eyelid.. On inspection and slit lamp examination, the patients manifested the characteristic lesion of a white translucent papule with a central black pit. Scraping of the lesion revealed a gravid adult female flea, allowing the diagnosis of infection with the flea T. penetrans. After removal of the parasite, a complete local recovery occurred over a 1-week period with local application of tetracycline.. With the increase in international travelling, it is useful to know that eyelid localisation of T. penetrans is possible.

Topics: Adolescent; Animals; Child; Ectoparasitic Infestations; Edema; Eyelid Diseases; Eyelids; Female; Humans; Male; Ophthalmologic Surgical Procedures; Pruritus; Siphonaptera; Tetracycline

We present an unusual case of recurrent swelling after removal of the submandibular and sublingual salivary glands which was found to be the result of a collection of plasma. This was successfully treated by an injection of tetracycline to induce sclerosis.

Topics: Adult; Blood; Edema; Female; Humans; Mouth Floor; Oral Surgical Procedures; Postoperative Hemorrhage; Sclerosing Solutions; Sublingual Gland; Submandibular Gland; Tetracycline

Mucosal changes have been well described in chronic sinusitis, yet little is known about the underlying bone, despite clinical and experimental evidence suggesting that bone may be involved in chronic sinusitis. Techniques of undecalcified bone analysis were used for detailed histologic examination of ethmoid bone in chronic sinusitis compared with controls. Bone synthesis, resorption, and inflammatory cell presence were specifically assessed. Additionally, histomorphometry techniques were used to determine ethmoid bone physiology in individuals undergoing surgery for chronic sinusitis. Overall, individuals undergoing surgery for chronic sinusitis were found to have evidence of marked acceleration in bone physiology with histologic changes including new bone formation, fibrosis, and presence of inflammatory cells. These findings are compared with osteomyelitis in long bone and the jaw. The suggestion that underlying bone may serve as a catalyst for chronic sinusitis is supported and implications for therapy are discussed.

Topics: Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Bone Remodeling; Bone Resorption; Chronic Disease; Coloring Agents; Demeclocycline; Edema; Endoscopy; Ethmoid Bone; Ethmoid Sinusitis; Female; Fibrosis; Humans; Male; Mandibular Diseases; Mucous Membrane; Osteitis; Osteogenesis; Osteomyelitis; Prospective Studies; Rhinitis; Single-Blind Method; Tetracycline; Turbinates

The common preventive therapy in our department for newborns' eyes is tetracycline ophthalmic ointment. Due to temporary shortage of tetracycline ophthalmic ointment for one week in December 1991, the preventive therapy given to seventy-one newborns was gentamicin sulfate ophthalmic ointment. Five babies (7 percent of all newborns) experienced marked edema of the eyelids, foci of erythema, and serous exudate within the first days of life. The lesions regressed gradually and disappeared entirely within two to three weeks without any complications. These lesions represent the first description of orbital irritant contact dermatitis in newborns, most probably caused by topical gentamicin preparation. However, one cannot exclude sensitivity to paraben, which is the preservative used in gentamicin ointment, or a synergistic action of both agent and preservative.

Topics: Anti-Bacterial Agents; Dermatitis, Irritant; Drug Eruptions; Edema; Erythema; Exudates and Transudates; Eyelid Diseases; Follow-Up Studies; Gentamicins; Humans; Infant, Newborn; Ointments; Ophthalmic Solutions; Orbital Diseases; Parabens; Preservatives, Pharmaceutical; Tetracycline

Five patients who developed seromas following mastectomy with lymph node dissection were treated with aspiration of the seromas and instillation of a sclerosant solution containing tetracycline. All seromas resolved promptly without infection, flap necrosis, or recurrence. The technique is recommended for treatment of this postoperative complication.

Topics: Adenocarcinoma; Aged; Breast Neoplasms; Edema; Female; Humans; Mastectomy; Middle Aged; Postoperative Complications; Sclerosing Solutions; Surgical Wound Infection; Tetracycline

Tetracycline pharmacokinetics were studied in a group of normal subjects and in patients with nutritional oedema. Though both groups of subjects received similar dose per kilogram body weight, plasma concentrations and area under the curve (AUC) were significantly higher in nutritional oedema patients. The total body clearance of the drug was reduced due to significant reductions in renal and non-renal clearance of drug. The volume of distribution (VB) was low, with significant increase in rate of transfer of drug from peripheral to central compartment (K21), indicating poor tissue sequestration of the drug in nutritional-oedema patients. In some respects, these alterations in kinetics of tetracycline in nutritional-oedema patients are different from our earlier observations made in undernourished subjects who had mild and moderate forms of malnutrition. These results suggest that changes in disposition of drugs are also influenced by the severity of malnutrition, and demand suitable alterations in dosage regimen.

Topics: Edema; Half-Life; Humans; Kinetics; Metabolic Clearance Rate; Protein-Energy Malnutrition; Tetracycline

In the study on regional difference in susceptibility to damage of vestibulo-semicircular canals upon causing labyrinthine lesion by four different procedures, namely, by intracranial approach, through the middle ear, through the facial nerve and by means of experimental endolymphatic hydrops, the following results were obtained. 1. The crista of posterior semicircular canal among the semicircular canals and the macula of the saccule within the vestibule were most susceptible to impairment. In other words, the most susceptible region was the so-called pars inferior. In regard to the impairment of the cupulas, the posterior semicircular canal was the most susceptible region. 2. Recovery from markedly reduced caloric nystagmus within a short period so as to see provocation of caloric nystagmus may result from the reconstruction of the cupulas and the normalization of vacuole-like findings of the sensory epithelium.

Topics: Animals; Ear, Middle; Edema; Endolymphatic Sac; Eye Movements; Facial Nerve; Guinea Pigs; Herpesviridae Infections; Immune Sera; Labyrinth Diseases; Rabbits; Sodium Hydroxide; Staphylococcal Infections; Subarachnoid Space; Tetracycline; Vestibulocochlear Nerve Injuries

Out of 8 patients with Whipple's disease, 7 had roentgenographic findings consisting of slight dilatation of the small bowel, with thickening of the mucosal folds. The eighth patient had no abnormality on roentgenographic study. This series represents the first in which the roentgenographic changes have been quantitatively assessed. Confirmation of the diagnosis by biopsy is important because antibiotic treatment results in marked improvement both clinically and roentgenographically.

Topics: Adult; Aged; Amenorrhea; Biopsy; Body Weight; Diagnosis, Differential; Diarrhea; Duodenum; Edema; Female; Fever; Follow-Up Studies; Humans; Intestinal Mucosa; Intestine, Small; Jejunum; Joint Diseases; Lymphadenitis; Male; Middle Aged; Pain; Pigmentation Disorders; Purpura; Radiography; Tetracycline; Whipple Disease

Local footpad infection in mouse was investigated with 55 clinically isolated strains of Staphylococcus aureus. When 10(7) viable cells were inoculated into the footpad, local swelling and bacterial growth resulted after 24 hr. With a dose of 10(6) cells, moderate swelling was observed after a few hours but the reaction had almost disappeared after 24 hr. About 75% of the staphylococcal strains tested caused footpad edema in mice at doses of 10(7) cells. A statistical comparison of the virulence of the organisms on intravenous and intraperitoneal injection with that in inducing footpad swelling is also reported.

Topics: Ampicillin; Animals; Bacteriophage Typing; Chloramphenicol; Edema; Erythromycin; Female; Foot; Injections, Intraperitoneal; Injections, Intravenous; Kanamycin; Mice; Penicillin G; Sepsis; Staphylococcal Infections; Staphylococcus; Streptomycin; Tetracycline; Time Factors; Virulence

Topics: Acetaminophen; Adult; Brompheniramine; Dental Caries; Edema; Female; Humans; Iatrogenic Disease; Oral Hemorrhage; Periapical Tissue; Periodontal Diseases; Pulpectomy; Root Canal Obturation; Root Canal Therapy; Sodium Hypochlorite; Tetracycline; Therapeutic Irrigation

Topics: Adult; Child, Preschool; Darier Disease; Edema; Fever; gamma-Globulins; Hematocrit; Humans; Leukocyte Count; Middle Aged; Smallpox Vaccine; Staphylococcus; Tetracycline; Thiosemicarbazones; Vaccination; Vaccinia; Vaccinia virus

Topics: Animals; Candida albicans; Candidiasis; Candidiasis, Oral; Edema; Epithelium; Female; Inflammation; Leukoplakia, Oral; Male; Mouth; Rats; Tetracycline; Time Factors; Tongue

Topics: Adrenal Glands; Animals; Anti-Inflammatory Agents; Carrageenan; Complement System Proteins; Corticosterone; Edema; Inflammation; Male; p-Methoxy-N-methylphenethylamine; Pleurisy; Rats; Tetracycline; Turpentine

Topics: Adult; Albumins; Alkalosis; Amino Acids; Anorexia Nervosa; Arteries; Bicarbonates; Blood Proteins; Edema; Feces; Folic Acid; Haptoglobins; Hemoglobins; Humans; Hydrogen-Ion Concentration; Hypokalemia; Iron; Kidney; Lipid Metabolism; Lipoproteins; Male; Muscles; Muscular Atrophy; Nitrogen; Nutrition Disorders; Potassium; Protein Binding; Psychotherapy; Serum Albumin; Serum Globulins; Spleen; Tetracycline; Thinness; Time Factors; Urine; Veins; Vomiting

Topics: Edema; Eye Diseases; Female; Humans; Middle Aged; Sinusitis; Tetracycline

Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agents; Aspirin; Azaguanine; Azathioprine; Bacteria; Benzimidazoles; Depression, Chemical; Edema; Enterococcus faecalis; Flufenamic Acid; Fungi; Indomethacin; Lactobacillus; Mefenamic Acid; Mercaptopurine; Oxyphenbutazone; Phenylbutazone; Purines; Pyrimethamine; Rats; Riboflavin; Salicylates; Staphylococcus; Tetracycline; Thioguanine

Topics: Animals; Benzene; Cyclophosphamide; Dermatitis, Contact; Dinitrophenols; Edema; Erythema; Guinea Pigs; Immunodiffusion; Leukopenia; Lymphocytes; Promethazine; Proteins; Skin; Tetracycline; Tissue Extracts

Topics: Adrenal Cortex Hormones; Edema; Postoperative Complications; Surgery, Oral; Tetracycline

Topics: Anti-Bacterial Agents; Cyanosis; Drug Eruptions; Drug Hypersensitivity; Edema; Episiotomy; Erythromycin Ethylsuccinate; Female; Fever; Hearing Disorders; Humans; Hysterectomy; Neomycin; Nystatin; Penicillins; Postoperative Care; Pregnancy; Pregnancy, Ectopic; Streptomycin; Tetracycline

Topics: Drug Synergism; Edema; Female; Genital Diseases, Female; Humans; Peptide Hydrolases; Tetracycline

Topics: Aerosols; Animals; Cats; Chloramphenicol; Chlortetracycline; Dogs; Edema; Guinea Pigs; Mice; Mucous Membrane; Penicillins; Rabbits; Rats; Respiratory System; Streptomycin; Tetracycline

Topics: Biomedical Research; Blood Gas Analysis; Bronchitis; Bronchitis, Chronic; Congenital Abnormalities; Drainage; Edema; Humans; Obesity; Penicillin G; Physical Therapy Modalities; Posture; Pulmonary Heart Disease; Respiratory Function Tests; Respiratory Insufficiency; Tetracycline; Therapeutics; Tracheotomy