tetracycline and Cough

Topics: Aerosols; Aged; Antifungal Agents; Bronchiectasis; Bronchitis; Cough; Dyspnea; Female; Humans; Male; Middle Aged; Sputum; Tetracycline

European guidelines for treating acute cough/lower respiratory tract infection (LRTI) aim to reduce nonevidence-based variation in prescribing, and better target and increase the use of first-line antibiotics. However, their application in primary care is unknown. We explored congruence of both antibiotic prescribing and antibiotic choice with European Respiratory Society (ERS)/European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines for managing LRTI. The present study was an analysis of prospective observational data from patients presenting to primary care with acute cough/LRTI. Clinicians recorded symptoms on presentation, and their examination and management. Patients were followed up with self-complete diaries. 1,776 (52.7%) patients were prescribed antibiotics. Given patients' clinical presentation, clinicians could have justified an antibiotic prescription for 1,915 (71.2%) patients according to the ERS/ESCMID guidelines. 761 (42.8%) of those who were prescribed antibiotics received a first-choice antibiotic (i.e. tetracycline or amoxicillin). Ciprofloxacin was prescribed for 37 (2.1%) and cephalosporins for 117 (6.6%). A lack of specificity in definitions in the ERS/ESCMID guidelines could have enabled clinicians to justify a higher rate of antibiotic prescription. More studies are needed to produce specific clinical definitions and indications for treatment. First-choice antibiotics were prescribed to the minority of patients who received an antibiotic prescription.

Topics: Acute Disease; Adult; Amoxicillin; Anti-Bacterial Agents; Cephalosporins; Ciprofloxacin; Cough; Drug Resistance, Bacterial; Europe; Female; Guideline Adherence; Humans; Male; Middle Aged; Primary Health Care; Prospective Studies; Respiratory Tract Infections; Tetracycline

Between August 1974 and October 1975 78 patients with mycoplasma-pneumonia-infection were admitted to the 3 pediatric clinics of Hannover. Their clinical and radiological findings were studied. 20 patients with serological diagnosis of additional viral infection were not included in this study. The clinical diagnosis was confirmed by complement fixation test. The commonest symptoms were fever, coughing and abnormal auscultatory findings over the lungs. Chest roentgenograms showed three different patterns of infiltration: 1. Disseminated, non homogenous bronchial lines and mottled shadows often with swollen hilar lymphnodes in 46% of all patients.--2. Homogenous, extensive, opaque infiltrates in 29% of all patients.--3. Perivascular and peribronchial infiltrates at the hilus with or without swollen lymphnodes in 21% of all patients.--This means that in half of the patients abnormal signs in chestroentgenogram (type 2 and 3) were present, which formerly were described as "atypical pneumonia."--4. There were no radiological symptoms in 4% of the patients.--Those who were treated with tetracyclin or erythromycin became afebrile within 1--3 days, in those who didn't get antibiotics at all or were treated with other antibiotics fever lasted longer.

Topics: Adolescent; Auscultation; Child; Child, Preschool; Complement Fixation Tests; Cough; Erythromycin; Female; Humans; Infant; Male; Mycoplasma Infections; Pneumonia; Radiography; Tetracycline

Topics: Adult; Aminosalicylic Acids; Blister; Carcinoma; Chronic Disease; Cough; Diagnosis, Differential; Humans; Isoniazid; Lung; Lung Diseases; Lung Neoplasms; Male; Radiography; Smoking; Spirometry; Sputum; Streptomycin; Syncope; Tetracycline; Tomography

Topics: Adolescent; Adult; Aged; Animals; Birds; Complement Fixation Tests; Cough; England; Female; Humans; Male; Middle Aged; Psittacosis; Radiography; Seasons; Sex Factors; Tetracycline; Zoonoses

Topics: Animals; Asthenia; Chlamydia; Columbidae; Communicable Diseases; Complement Fixation Tests; Cough; France; Humans; Lung Diseases; Lymph Nodes; Pneumonia, Viral; Psittacosis; Radiography, Thoracic; Tetracycline; Tomography