Page last updated: 2024-10-20

taurine and Diarrhea

taurine has been researched along with Diarrhea in 21 studies

Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.

Research Excerpts

ExcerptRelevanceReference
"The effects of dietary taurine on the experimental colitis induced by dextran sulfate sodium (DSS) in mice were evaluated."7.74Attenuation by dietary taurine of dextran sulfate sodium-induced colitis in mice and of THP-1-induced damage to intestinal Caco-2 cell monolayers. ( Fujisawa, M; Hori, M; Ishimoto, Y; Kakuta, S; Nambu, A; Ozaki, H; Satsu, H; Shimizu, M; Totsuka, M; Zhao, Z, 2008)
"Acamprosate has a different mechanism of action than other drugs used for maintenance of abstinence from alcohol and is generally well tolerated."5.33Acamprosate campral for alcoholism. ( , 2005)
"Relevant information was identified through searches of MEDLINE (1966 to March 2005), International Pharmaceutical Abstracts (1970-2005), Current Contents (1996-2005), and Cumulative Index to Nursing and Allied Health Literature (1982-Week 2, 2004) using the key words acamprosate, alcohol dependence, and alcoholism (MeSH)."4.82Acamprosate for the treatment of alcohol dependence. ( Boothby, LA; Doering, PL, 2005)
"The effects of dietary taurine on the experimental colitis induced by dextran sulfate sodium (DSS) in mice were evaluated."3.74Attenuation by dietary taurine of dextran sulfate sodium-induced colitis in mice and of THP-1-induced damage to intestinal Caco-2 cell monolayers. ( Fujisawa, M; Hori, M; Ishimoto, Y; Kakuta, S; Nambu, A; Ozaki, H; Satsu, H; Shimizu, M; Totsuka, M; Zhao, Z, 2008)
"Acamprosate is a newly registered drug that appears to reduce alcohol-drinking in both animal models and clinical conditions."2.68Efficacy and safety of acamprosate in the treatment of detoxified alcohol-dependent patients. A 90-day placebo-controlled dose-finding study. ( Gavrilovic, M; Le Bon, O; Lehert, P; Lion, K; Pelc, I; Verbanck, P, 1997)
"Acamprosate appears to be an effective and safe treatment strategy for supporting continuous abstinence after detoxification in alcohol dependent patients."2.46Acamprosate for alcohol dependence. ( Hackl-Herrwerth, A; Lehert, P; Leucht, S; Rösner, S; Soyka, M; Vecchi, S, 2010)
"Acamprosate has a different mechanism of action than other drugs used for maintenance of abstinence from alcohol and is generally well tolerated."1.33Acamprosate campral for alcoholism. ( , 2005)
"The glycine/taurine-ratio was increased in 8 of 17 patients with Crohn's disease, but in only one of the 20 control patients."1.26Bile acid metabolism and plasma protein turnover in Crohn's disease. ( Jarnum, S; Jensen, KB; Lenz, K, 1976)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-199014 (66.67)18.7374
1990's1 (4.76)18.2507
2000's4 (19.05)29.6817
2010's2 (9.52)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mason, BJ1
Heyser, CJ1
Rösner, S1
Hackl-Herrwerth, A1
Leucht, S1
Lehert, P2
Vecchi, S1
Soyka, M1
Boothby, LA1
Doering, PL1
Aisen, PS1
Saumier, D1
Briand, R1
Laurin, J1
Gervais, F1
Tremblay, P1
Garceau, D1
Zhao, Z1
Satsu, H1
Fujisawa, M1
Hori, M1
Ishimoto, Y1
Totsuka, M1
Nambu, A1
Kakuta, S1
Ozaki, H1
Shimizu, M1
Pelc, I1
Verbanck, P1
Le Bon, O1
Gavrilovic, M1
Lion, K1
Ghisolfi, J1
Charlet, P1
Ser, N1
Salvayre, R1
Thouvenot, JP1
Duole, C1
Watkins, JB1
Perman, JA1
Lenz, K2
Jensen, KB1
Jarnum, S1
Gaze, H1
Murphy, GM1
Nelson, R1
Corkery, JJ1
Anderson, CM1
Ferraris, R1
Jazrawi, R1
Bridges, C1
Northfield, TC1
Schneider, RE1
Viteri, FE1
Papp, JP1
Danö, P1
Dekker, W1
Sanders, GT1
van den Ende, A1
Samson, G1
Tijtgat, GN1
O'Leary, JP1
Thomas, WC1
Woodward, ER1
Konturek, S1
Garbutt, JT1
Kenney, TJ1
Cassells, JS1
Banwell, JG1
Gorbach, SL1
Mitra, R1
Mazumder, DN1
Bruusgaard, A1
Thaysen, EH1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776]Phase 254 participants (Actual)Interventional2017-08-07Completed
Campral (Acamprosate) Treatment of Alcohol Dependence in a Family Medicine Setting: A Randomized, Double-Blind Placebo-Controlled Study[NCT00381043]Phase 4100 participants (Actual)Interventional2006-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Prefrontal GABA+ Concentrations

Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition

Interventionmmol/kg (Mean)
N-Acetylcysteine3.90
Gabapentin3.93
Placebo Oral Tablet3.73

Prefrontal Glx Concentrations

Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition

Interventionmmol/kg (Mean)
N-Acetylcysteine21.59
Gabapentin21.69
Placebo Oral Tablet22.25

% Compliant With Medication

% of individuals with evidence for 80% compliance with medication based on returned blister packs and weekly diaries. (NCT00381043)
Timeframe: 12 weeks

Interventionpercentage of participants (Number)
1- Acamprosate93.3
2 - Sugar Pill - Placebo91.6

% Dropout

Percentage of participants who dropped out of study by drug condition (NCT00381043)
Timeframe: 12 weeks

Interventionpercentage of participants (Number)
1- Acamprosate21.5
2 - Sugar Pill - Placebo16.3

% Heavy Drinking Days During Trial

% of Heavy drinking days (5 or more drinks/d for a man or 4 or more drinks/d for a woman) over the 12 weeks of the trial. (NCT00381043)
Timeframe: 12 weeks

Interventionpercentage of heavy drinking days (Mean)
1- Acamprosate15.8
2 - Sugar Pill - Placebo18.4

Clinical Global Impression Scale

Range of overall severity of illness: 1, normal, not at all ill; 2, borderline ill; 3, mildly ill; 4, moderately ill; 5, markedly ill; 6, severely ill; or 7, extremely ill (NCT00381043)
Timeframe: 12 weeks

Interventionunits on a scale (Mean)
1- Acamprosate2.3
2 - Sugar Pill - Placebo2.4

Percent Days Abstinent

%Days without any alcohol consumption over the treatment period (NCT00381043)
Timeframe: 12 weeks

Interventionpercentage of days (Mean)
1- Acamprosate40.7
2 - Sugar Pill - Placebo41.6

Percent With Complete Abstinence

% of subjects with no drinking during the 12 week treatment trial (NCT00381043)
Timeframe: 12 weeks

Interventionpercentage of participants (Number)
1- Acamprosate5.9
2 - Sugar Pill - Placebo19.1

Retention

Number of individuals retained in the trial by acamprosate vs placebo group (NCT00381043)
Timeframe: 12 weeks

Interventionparticipants (Number)
1- Acamprosate39
2 - Sugar Pill - Placebo41

Reviews

6 reviews available for taurine and Diarrhea

ArticleYear
The neurobiology, clinical efficacy and safety of acamprosate in the treatment of alcohol dependence.
    Expert opinion on drug safety, 2010, Volume: 9, Issue:1

    Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Animals; Cognition; Diarrhea; Disease Models, Animal; D

2010
Acamprosate for alcohol dependence.
    The Cochrane database of systematic reviews, 2010, Sep-08, Issue:9

    Topics: Acamprosate; Adult; Alcohol Deterrents; Alcohol-Related Disorders; Diarrhea; Humans; Placebo Effect;

2010
Acamprosate for the treatment of alcohol dependence.
    Clinical therapeutics, 2005, Volume: 27, Issue:6

    Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Diarrhea; Humans; Meta-Analysis as Topic; Molecular Str

2005
Bile acid metabolism in infants and children.
    Clinics in gastroenterology, 1977, Volume: 6, Issue:1

    Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Cholestasis; Cystic Fibrosis; Diarrhea; Digestive Syste

1977
Bile salts in health and disease.
    Michigan medicine, 1972, Volume: 71, Issue:30

    Topics: Bile Acids and Salts; Biliary Tract Diseases; Blind Loop Syndrome; Celiac Disease; Chenodeoxycholic

1972
[Clinical aspects of intestino-hepatic circulation of bile acids].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1971, Nov-22, Volume: 26, Issue:47

    Topics: Bile Acids and Salts; Biological Transport, Active; Cholesterol; Diarrhea; Feedback; Glycine; Humans

1971

Trials

2 trials available for taurine and Diarrhea

ArticleYear
A Phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease.
    Neurology, 2006, Nov-28, Volume: 67, Issue:10

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Brain; Diarrhea; Dose-Response Re

2006
Efficacy and safety of acamprosate in the treatment of detoxified alcohol-dependent patients. A 90-day placebo-controlled dose-finding study.
    The British journal of psychiatry : the journal of mental science, 1997, Volume: 171

    Topics: Acamprosate; Adolescent; Adult; Aged; Alcohol Deterrents; Alcoholism; Diarrhea; Dose-Response Relati

1997

Other Studies

13 other studies available for taurine and Diarrhea

ArticleYear
Acamprosate campral for alcoholism.
    The Medical letter on drugs and therapeutics, 2005, Jan-03, Volume: 47, Issue:1199

    Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Diarrhea; Disulfiram; Drug Therapy, Combination; Humans

2005
Attenuation by dietary taurine of dextran sulfate sodium-induced colitis in mice and of THP-1-induced damage to intestinal Caco-2 cell monolayers.
    Amino acids, 2008, Volume: 35, Issue:1

    Topics: Animals; Caco-2 Cells; Colitis; Colon; Cytokines; Dextran Sulfate; Diarrhea; Dietary Supplements; Di

2008
Plasma free amino acids in normal children and in patients with proteinocaloric malnutrition: fasting and infection.
    Pediatric research, 1978, Volume: 12, Issue:9

    Topics: Amino Acids; Child, Preschool; Diarrhea; Fasting; Humans; Infant; Infant, Newborn; Infections; Lysin

1978
Bile acid metabolism and plasma protein turnover in Crohn's disease.
    Scandinavian journal of gastroenterology, 1976, Volume: 11, Issue:7

    Topics: Adolescent; Adult; Bile Acids and Salts; Blood Proteins; Child; Crohn Disease; Diarrhea; Duodenum; F

1976
Bile acid excretion after pull-through operation for Hirschsprung's disease.
    Archives of disease in childhood, 1975, Volume: 50, Issue:3

    Topics: Adolescent; Bile Acids and Salts; Chenodeoxycholic Acid; Child; Child, Preschool; Cholic Acids; Deox

1975
Use of a gamma-labeled bile acid (75SeHCAT) as a test of ileal function. Methods of improving accuracy.
    Gastroenterology, 1986, Volume: 90, Issue:5 Pt 1

    Topics: Adult; Aged; Bile Acids and Salts; Chlorides; Chromium; Chromium Compounds; Chromium Radioisotopes;

1986
Luminal events of lipid absorption in protein-calorie malnourished children; relationship with nutritional recovery and diarrhea. II. Alterations in bile acid content of duodenal aspirates.
    The American journal of clinical nutrition, 1974, Volume: 27, Issue:8

    Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Child Nutritional Physiological Phenomena; Child, Presc

1974
Change of bile acid metabolism and absorption of vitamin B 12 after intestinal shunt operation in obesity. A comparison of three types of operation.
    Scandinavian journal of gastroenterology, 1974, Volume: 9, Issue:2

    Topics: Adolescent; Adult; Bacteroides; Bile Acids and Salts; Breath Tests; Carbon Dioxide; Carbon Radioisot

1974
[Cholereic diarrhea and oxalate nephrolithiasis].
    Nederlands tijdschrift voor geneeskunde, 1973, Dec-22, Volume: 117, Issue:51

    Topics: Adult; Bile Acids and Salts; Cholestyramine Resin; Diarrhea; Feces; Humans; Kidney Calculi; Male; Ox

1973
Urinary tract stone after small bowel bypass for morbid obesity.
    American journal of surgery, 1974, Volume: 127, Issue:2

    Topics: Adult; Calcium; Cholestyramine Resin; Diarrhea; Diet; Diet Therapy; Diet, Reducing; Female; Humans;

1974
Effect of cholestyramine on bile acid metabolism in normal man.
    The Journal of clinical investigation, 1972, Volume: 51, Issue:11

    Topics: Adult; Bile Acids and Salts; Carbon Isotopes; Cholestyramine Resin; Chromatography, Gas; Chromatogra

1972
Tropical sprue and malnutrition in West Bengal. IV. Bile salt deconjugation in tropical sprue.
    The American journal of clinical nutrition, 1970, Volume: 23, Issue:12

    Topics: Adult; Bile Acids and Salts; Celiac Disease; Diarrhea; Female; Humans; Ileum; Jejunum; Male; Middle

1970
Increased ratio of glycine-taurine conjugated bile acids in the early diagnosis of terminal ileopathy. Preliminary report.
    Acta medica Scandinavica, 1970, Volume: 188, Issue:6

    Topics: Adult; Bile Acids and Salts; Celiac Disease; Crohn Disease; Diarrhea; Duodenum; Female; Glycine; Hum

1970