taurine and Diarrhea
taurine has been researched along with Diarrhea in 21 studies
Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of dietary taurine on the experimental colitis induced by dextran sulfate sodium (DSS) in mice were evaluated." | 7.74 | Attenuation by dietary taurine of dextran sulfate sodium-induced colitis in mice and of THP-1-induced damage to intestinal Caco-2 cell monolayers. ( Fujisawa, M; Hori, M; Ishimoto, Y; Kakuta, S; Nambu, A; Ozaki, H; Satsu, H; Shimizu, M; Totsuka, M; Zhao, Z, 2008) |
| "Acamprosate has a different mechanism of action than other drugs used for maintenance of abstinence from alcohol and is generally well tolerated." | 5.33 | Acamprosate campral for alcoholism. ( , 2005) |
| "Relevant information was identified through searches of MEDLINE (1966 to March 2005), International Pharmaceutical Abstracts (1970-2005), Current Contents (1996-2005), and Cumulative Index to Nursing and Allied Health Literature (1982-Week 2, 2004) using the key words acamprosate, alcohol dependence, and alcoholism (MeSH)." | 4.82 | Acamprosate for the treatment of alcohol dependence. ( Boothby, LA; Doering, PL, 2005) |
| "The effects of dietary taurine on the experimental colitis induced by dextran sulfate sodium (DSS) in mice were evaluated." | 3.74 | Attenuation by dietary taurine of dextran sulfate sodium-induced colitis in mice and of THP-1-induced damage to intestinal Caco-2 cell monolayers. ( Fujisawa, M; Hori, M; Ishimoto, Y; Kakuta, S; Nambu, A; Ozaki, H; Satsu, H; Shimizu, M; Totsuka, M; Zhao, Z, 2008) |
| "Acamprosate is a newly registered drug that appears to reduce alcohol-drinking in both animal models and clinical conditions." | 2.68 | Efficacy and safety of acamprosate in the treatment of detoxified alcohol-dependent patients. A 90-day placebo-controlled dose-finding study. ( Gavrilovic, M; Le Bon, O; Lehert, P; Lion, K; Pelc, I; Verbanck, P, 1997) |
| "Acamprosate appears to be an effective and safe treatment strategy for supporting continuous abstinence after detoxification in alcohol dependent patients." | 2.46 | Acamprosate for alcohol dependence. ( Hackl-Herrwerth, A; Lehert, P; Leucht, S; Rösner, S; Soyka, M; Vecchi, S, 2010) |
| "Acamprosate has a different mechanism of action than other drugs used for maintenance of abstinence from alcohol and is generally well tolerated." | 1.33 | Acamprosate campral for alcoholism. ( , 2005) |
| "The glycine/taurine-ratio was increased in 8 of 17 patients with Crohn's disease, but in only one of the 20 control patients." | 1.26 | Bile acid metabolism and plasma protein turnover in Crohn's disease. ( Jarnum, S; Jensen, KB; Lenz, K, 1976) |
Research
Studies (21)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (66.67) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 4 (19.05) | 29.6817 |
| 2010's | 2 (9.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Mason, BJ | 1 |
| Heyser, CJ | 1 |
| Rösner, S | 1 |
| Hackl-Herrwerth, A | 1 |
| Leucht, S | 1 |
| Lehert, P | 2 |
| Vecchi, S | 1 |
| Soyka, M | 1 |
| Boothby, LA | 1 |
| Doering, PL | 1 |
| Aisen, PS | 1 |
| Saumier, D | 1 |
| Briand, R | 1 |
| Laurin, J | 1 |
| Gervais, F | 1 |
| Tremblay, P | 1 |
| Garceau, D | 1 |
| Zhao, Z | 1 |
| Satsu, H | 1 |
| Fujisawa, M | 1 |
| Hori, M | 1 |
| Ishimoto, Y | 1 |
| Totsuka, M | 1 |
| Nambu, A | 1 |
| Kakuta, S | 1 |
| Ozaki, H | 1 |
| Shimizu, M | 1 |
| Pelc, I | 1 |
| Verbanck, P | 1 |
| Le Bon, O | 1 |
| Gavrilovic, M | 1 |
| Lion, K | 1 |
| Ghisolfi, J | 1 |
| Charlet, P | 1 |
| Ser, N | 1 |
| Salvayre, R | 1 |
| Thouvenot, JP | 1 |
| Duole, C | 1 |
| Watkins, JB | 1 |
| Perman, JA | 1 |
| Lenz, K | 2 |
| Jensen, KB | 1 |
| Jarnum, S | 1 |
| Gaze, H | 1 |
| Murphy, GM | 1 |
| Nelson, R | 1 |
| Corkery, JJ | 1 |
| Anderson, CM | 1 |
| Ferraris, R | 1 |
| Jazrawi, R | 1 |
| Bridges, C | 1 |
| Northfield, TC | 1 |
| Schneider, RE | 1 |
| Viteri, FE | 1 |
| Papp, JP | 1 |
| Danö, P | 1 |
| Dekker, W | 1 |
| Sanders, GT | 1 |
| van den Ende, A | 1 |
| Samson, G | 1 |
| Tijtgat, GN | 1 |
| O'Leary, JP | 1 |
| Thomas, WC | 1 |
| Woodward, ER | 1 |
| Konturek, S | 1 |
| Garbutt, JT | 1 |
| Kenney, TJ | 1 |
| Cassells, JS | 1 |
| Banwell, JG | 1 |
| Gorbach, SL | 1 |
| Mitra, R | 1 |
| Mazumder, DN | 1 |
| Bruusgaard, A | 1 |
| Thaysen, EH | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
| Campral (Acamprosate) Treatment of Alcohol Dependence in a Family Medicine Setting: A Randomized, Double-Blind Placebo-Controlled Study[NCT00381043] | Phase 4 | 100 participants (Actual) | Interventional | 2006-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Prefrontal GABA+ Concentrations
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 3.90 |
| Gabapentin | 3.93 |
| Placebo Oral Tablet | 3.73 |
Prefrontal Glx Concentrations
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 21.59 |
| Gabapentin | 21.69 |
| Placebo Oral Tablet | 22.25 |
% Compliant With Medication
% of individuals with evidence for 80% compliance with medication based on returned blister packs and weekly diaries. (NCT00381043)
Timeframe: 12 weeks
| Intervention | percentage of participants (Number) |
|---|---|
| 1- Acamprosate | 93.3 |
| 2 - Sugar Pill - Placebo | 91.6 |
% Dropout
Percentage of participants who dropped out of study by drug condition (NCT00381043)
Timeframe: 12 weeks
| Intervention | percentage of participants (Number) |
|---|---|
| 1- Acamprosate | 21.5 |
| 2 - Sugar Pill - Placebo | 16.3 |
% Heavy Drinking Days During Trial
% of Heavy drinking days (5 or more drinks/d for a man or 4 or more drinks/d for a woman) over the 12 weeks of the trial. (NCT00381043)
Timeframe: 12 weeks
| Intervention | percentage of heavy drinking days (Mean) |
|---|---|
| 1- Acamprosate | 15.8 |
| 2 - Sugar Pill - Placebo | 18.4 |
Clinical Global Impression Scale
Range of overall severity of illness: 1, normal, not at all ill; 2, borderline ill; 3, mildly ill; 4, moderately ill; 5, markedly ill; 6, severely ill; or 7, extremely ill (NCT00381043)
Timeframe: 12 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| 1- Acamprosate | 2.3 |
| 2 - Sugar Pill - Placebo | 2.4 |
Percent Days Abstinent
%Days without any alcohol consumption over the treatment period (NCT00381043)
Timeframe: 12 weeks
| Intervention | percentage of days (Mean) |
|---|---|
| 1- Acamprosate | 40.7 |
| 2 - Sugar Pill - Placebo | 41.6 |
Percent With Complete Abstinence
% of subjects with no drinking during the 12 week treatment trial (NCT00381043)
Timeframe: 12 weeks
| Intervention | percentage of participants (Number) |
|---|---|
| 1- Acamprosate | 5.9 |
| 2 - Sugar Pill - Placebo | 19.1 |
Retention
Number of individuals retained in the trial by acamprosate vs placebo group (NCT00381043)
Timeframe: 12 weeks
| Intervention | participants (Number) |
|---|---|
| 1- Acamprosate | 39 |
| 2 - Sugar Pill - Placebo | 41 |
Reviews
6 reviews available for taurine and Diarrhea
| Article | Year |
|---|---|
The neurobiology, clinical efficacy and safety of acamprosate in the treatment of alcohol dependence.
Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Animals; Cognition; Diarrhea; Disease Models, Animal; D | 2010 |
Acamprosate for alcohol dependence.
Topics: Acamprosate; Adult; Alcohol Deterrents; Alcohol-Related Disorders; Diarrhea; Humans; Placebo Effect; | 2010 |
Acamprosate for the treatment of alcohol dependence.
Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Diarrhea; Humans; Meta-Analysis as Topic; Molecular Str | 2005 |
Bile acid metabolism in infants and children.
Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Cholestasis; Cystic Fibrosis; Diarrhea; Digestive Syste | 1977 |
Bile salts in health and disease.
Topics: Bile Acids and Salts; Biliary Tract Diseases; Blind Loop Syndrome; Celiac Disease; Chenodeoxycholic | 1972 |
[Clinical aspects of intestino-hepatic circulation of bile acids].
Topics: Bile Acids and Salts; Biological Transport, Active; Cholesterol; Diarrhea; Feedback; Glycine; Humans | 1971 |
Trials
2 trials available for taurine and Diarrhea
| Article | Year |
|---|---|
A Phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Brain; Diarrhea; Dose-Response Re | 2006 |
Efficacy and safety of acamprosate in the treatment of detoxified alcohol-dependent patients. A 90-day placebo-controlled dose-finding study.
Topics: Acamprosate; Adolescent; Adult; Aged; Alcohol Deterrents; Alcoholism; Diarrhea; Dose-Response Relati | 1997 |
Other Studies
13 other studies available for taurine and Diarrhea
| Article | Year |
|---|---|
Acamprosate campral for alcoholism.
Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Diarrhea; Disulfiram; Drug Therapy, Combination; Humans | 2005 |
Attenuation by dietary taurine of dextran sulfate sodium-induced colitis in mice and of THP-1-induced damage to intestinal Caco-2 cell monolayers.
Topics: Animals; Caco-2 Cells; Colitis; Colon; Cytokines; Dextran Sulfate; Diarrhea; Dietary Supplements; Di | 2008 |
Plasma free amino acids in normal children and in patients with proteinocaloric malnutrition: fasting and infection.
Topics: Amino Acids; Child, Preschool; Diarrhea; Fasting; Humans; Infant; Infant, Newborn; Infections; Lysin | 1978 |
Bile acid metabolism and plasma protein turnover in Crohn's disease.
Topics: Adolescent; Adult; Bile Acids and Salts; Blood Proteins; Child; Crohn Disease; Diarrhea; Duodenum; F | 1976 |
Bile acid excretion after pull-through operation for Hirschsprung's disease.
Topics: Adolescent; Bile Acids and Salts; Chenodeoxycholic Acid; Child; Child, Preschool; Cholic Acids; Deox | 1975 |
Use of a gamma-labeled bile acid (75SeHCAT) as a test of ileal function. Methods of improving accuracy.
Topics: Adult; Aged; Bile Acids and Salts; Chlorides; Chromium; Chromium Compounds; Chromium Radioisotopes; | 1986 |
Luminal events of lipid absorption in protein-calorie malnourished children; relationship with nutritional recovery and diarrhea. II. Alterations in bile acid content of duodenal aspirates.
Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Child Nutritional Physiological Phenomena; Child, Presc | 1974 |
Change of bile acid metabolism and absorption of vitamin B 12 after intestinal shunt operation in obesity. A comparison of three types of operation.
Topics: Adolescent; Adult; Bacteroides; Bile Acids and Salts; Breath Tests; Carbon Dioxide; Carbon Radioisot | 1974 |
[Cholereic diarrhea and oxalate nephrolithiasis].
Topics: Adult; Bile Acids and Salts; Cholestyramine Resin; Diarrhea; Feces; Humans; Kidney Calculi; Male; Ox | 1973 |
Urinary tract stone after small bowel bypass for morbid obesity.
Topics: Adult; Calcium; Cholestyramine Resin; Diarrhea; Diet; Diet Therapy; Diet, Reducing; Female; Humans; | 1974 |
Effect of cholestyramine on bile acid metabolism in normal man.
Topics: Adult; Bile Acids and Salts; Carbon Isotopes; Cholestyramine Resin; Chromatography, Gas; Chromatogra | 1972 |
Tropical sprue and malnutrition in West Bengal. IV. Bile salt deconjugation in tropical sprue.
Topics: Adult; Bile Acids and Salts; Celiac Disease; Diarrhea; Female; Humans; Ileum; Jejunum; Male; Middle | 1970 |
Increased ratio of glycine-taurine conjugated bile acids in the early diagnosis of terminal ileopathy. Preliminary report.
Topics: Adult; Bile Acids and Salts; Celiac Disease; Crohn Disease; Diarrhea; Duodenum; Female; Glycine; Hum | 1970 |