suramin has been researched along with Heart Failure in 3 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Blanco-Rivero, J | 1 |
| Couto, GK | 1 |
| Paula, SM | 1 |
| Fontes, MT | 1 |
| Rossoni, LV | 1 |
| Wu, Y | 1 |
| Sun, X | 1 |
| Ishida, J | 1 |
| Springer, J | 1 |
3 other studies available for suramin and Heart Failure
| Article | Year |
|---|---|
Enhanced sympathetic neurotransduction in the superior mesenteric artery in a rat model of heart failure: role of noradrenaline and ATP.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Desipra | 2021 |
Suramin against myostatin signaling may be considered to intervene in female patients with advanced heart failure.
Topics: Female; Heart Failure; Humans; Myostatin; Signal Transduction; Suramin | 2017 |
Reply to letter to the editor "suramin against myostatin signaling may be considered to intervene in female patients with advanced heart failure".
Topics: Female; Heart Failure; Humans; Myocardium; Myostatin; Signal Transduction; Suramin | 2017 |