Page last updated: 2024-11-04

suramin and Fever

suramin has been researched along with Fever in 10 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.

Research Excerpts

ExcerptRelevanceReference
" He presented with an inoculation chancre and was treated with suramin within four days of fever onset."3.78Human African trypanosomiasis in a Belgian traveller returning from the Masai Mara area, Kenya, February 2012. ( Asselman, V; Clerinx, J; Lejon, V; Maes, MB; Van de Casteele, S; Vlieghe, E, 2012)
"In January 2012, a case of Human African Trypanosomiasis (HAT) has been identified in Germany in a traveller returning from the Masai Mara area in Kenya."1.38Trypanosoma brucei rhodesiense infection in a German traveller returning from the Masai Mara area, Kenya, January 2012. ( Brodt, HR; Gottig, S; Just-Nuebling, G; Kleine, C; Wichelhaus, T; Wolf, T, 2012)
"Human African trypanosomiasis (sleeping sickness) is a parasitic infection transmitted by day-biting tsetse flies."1.33African trypanosomiasis in a British soldier. ( Croft, AM; Friend, HM; Jackson, CJ; Minton, EJ, 2006)
"Fever was initiated more rapidly in rats treated with suramin (7 nmol) or PPADS (70 nmol), however its late phase was unaffected."1.31Involvement of purinergic signalling in central mechanisms of body temperature regulation in rats. ( Gourine, AV; Gourine, VN; Melenchuk, EV; Poputnikov, DM; Spyer, KM, 2002)
"Suramin sodium is an aromatic polysulfonated compound that was originally introduced as an antiparasitic agent in the 1920s."1.28A pilot study of suramin in the treatment of metastatic renal cell carcinoma. ( Cooper, MR; Danesi, R; La Rocca, RV; Myers, CE; Stein, CA; Uhrich, M, 1991)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's5 (50.00)29.6817
2010's4 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Huits, R1
De Ganck, G1
Clerinx, J2
Büscher, P1
Bottieau, E1
Wolf, T1
Wichelhaus, T1
Gottig, S1
Kleine, C1
Brodt, HR1
Just-Nuebling, G1
Vlieghe, E1
Asselman, V1
Van de Casteele, S1
Maes, MB1
Lejon, V1
Richter, J1
Göbels, S1
Göbel, T1
Westenfeld, R1
Müller-Stöver, I1
Häussinger, D1
Gourine, AV2
Poputnikov, DM2
Zhernosek, N1
Melenchuk, EV2
Gerstberger, R1
Spyer, KM2
Gourine, VN2
Uslan, DZ1
Jacobson, KM1
Kumar, N1
Berbari, EF1
Orenstein, R1
Croft, AM1
Jackson, CJ1
Friend, HM1
Minton, EJ1
Moore, AC1
Ryan, ET1
Waldron, MA1
La Rocca, RV1
Stein, CA1
Danesi, R1
Cooper, MR1
Uhrich, M1
Myers, CE1

Other Studies

10 other studies available for suramin and Fever

ArticleYear
A veterinarian with fever, rash and chancre after holidays in Uganda.
    Journal of travel medicine, 2018, 01-01, Volume: 25, Issue:1

    Topics: Belgium; Female; Fever; Humans; Insect Bites and Stings; Middle Aged; Suramin; Travel; Trypanocidal

2018
Trypanosoma brucei rhodesiense infection in a German traveller returning from the Masai Mara area, Kenya, January 2012.
    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2012, Mar-08, Volume: 17, Issue:10

    Topics: Animals; Chancre; Diagnosis, Differential; Fever; Fluorescent Antibody Technique; Germany; Headache;

2012
Human African trypanosomiasis in a Belgian traveller returning from the Masai Mara area, Kenya, February 2012.
    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2012, Mar-08, Volume: 17, Issue:10

    Topics: Belgium; Chancre; Fever; Headache; Humans; Kenya; Male; Polymerase Chain Reaction; Suramin; Travel;

2012
A returning traveller with fever, facial swelling, and skin lesions.
    BMJ (Clinical research ed.), 2012, Mar-22, Volume: 344

    Topics: Adrenal Cortex Hormones; Animals; Diagnosis, Differential; Disease Progression; Face; Fever; Humans;

2012
P2 receptor blockade attenuates fever and cytokine responses induced by lipopolysaccharide in rats.
    British journal of pharmacology, 2005, Volume: 146, Issue:1

    Topics: Animals; Body Temperature; Fever; Interleukin-1; Interleukin-6; Lipopolysaccharides; Male; Purinergi

2005
A woman with fever and rash after African safari.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2006, Sep-01, Volume: 43, Issue:5

    Topics: Africa; Exanthema; Female; Fever; Humans; Melarsoprol; Middle Aged; Pentamidine; Suramin; Travel; Tr

2006
African trypanosomiasis in a British soldier.
    Journal of the Royal Army Medical Corps, 2006, Volume: 152, Issue:3

    Topics: Adult; Antinematodal Agents; Chancre; Erythema; Fever; Humans; Injections; Male; Military Personnel;

2006
Involvement of purinergic signalling in central mechanisms of body temperature regulation in rats.
    British journal of pharmacology, 2002, Volume: 135, Issue:8

    Topics: Adenosine Triphosphate; Animals; Body Temperature Regulation; Brain; Fever; Hypothalamus; Injections

2002
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 20-2002. A 37-year-old man with fever, hepatosplenomegaly, and a cutaneous foot lesion after a trip to Africa.
    The New England journal of medicine, 2002, Jun-27, Volume: 346, Issue:26

    Topics: Adult; Africa; Animals; Anthrax; Blood; Cerebrospinal Fluid; Diagnosis, Differential; Erythema; Feve

2002
A pilot study of suramin in the treatment of metastatic renal cell carcinoma.
    Cancer, 1991, Mar-15, Volume: 67, Issue:6

    Topics: Adult; Aged; Carcinoma, Renal Cell; Female; Fever; Gastrointestinal Diseases; Hematologic Diseases;

1991