suramin and Fever
suramin has been researched along with Fever in 10 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " He presented with an inoculation chancre and was treated with suramin within four days of fever onset." | 3.78 | Human African trypanosomiasis in a Belgian traveller returning from the Masai Mara area, Kenya, February 2012. ( Asselman, V; Clerinx, J; Lejon, V; Maes, MB; Van de Casteele, S; Vlieghe, E, 2012) |
| "In January 2012, a case of Human African Trypanosomiasis (HAT) has been identified in Germany in a traveller returning from the Masai Mara area in Kenya." | 1.38 | Trypanosoma brucei rhodesiense infection in a German traveller returning from the Masai Mara area, Kenya, January 2012. ( Brodt, HR; Gottig, S; Just-Nuebling, G; Kleine, C; Wichelhaus, T; Wolf, T, 2012) |
| "Human African trypanosomiasis (sleeping sickness) is a parasitic infection transmitted by day-biting tsetse flies." | 1.33 | African trypanosomiasis in a British soldier. ( Croft, AM; Friend, HM; Jackson, CJ; Minton, EJ, 2006) |
| "Fever was initiated more rapidly in rats treated with suramin (7 nmol) or PPADS (70 nmol), however its late phase was unaffected." | 1.31 | Involvement of purinergic signalling in central mechanisms of body temperature regulation in rats. ( Gourine, AV; Gourine, VN; Melenchuk, EV; Poputnikov, DM; Spyer, KM, 2002) |
| "Suramin sodium is an aromatic polysulfonated compound that was originally introduced as an antiparasitic agent in the 1920s." | 1.28 | A pilot study of suramin in the treatment of metastatic renal cell carcinoma. ( Cooper, MR; Danesi, R; La Rocca, RV; Myers, CE; Stein, CA; Uhrich, M, 1991) |
Research
Studies (10)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Huits, R | 1 |
| De Ganck, G | 1 |
| Clerinx, J | 2 |
| Büscher, P | 1 |
| Bottieau, E | 1 |
| Wolf, T | 1 |
| Wichelhaus, T | 1 |
| Gottig, S | 1 |
| Kleine, C | 1 |
| Brodt, HR | 1 |
| Just-Nuebling, G | 1 |
| Vlieghe, E | 1 |
| Asselman, V | 1 |
| Van de Casteele, S | 1 |
| Maes, MB | 1 |
| Lejon, V | 1 |
| Richter, J | 1 |
| Göbels, S | 1 |
| Göbel, T | 1 |
| Westenfeld, R | 1 |
| Müller-Stöver, I | 1 |
| Häussinger, D | 1 |
| Gourine, AV | 2 |
| Poputnikov, DM | 2 |
| Zhernosek, N | 1 |
| Melenchuk, EV | 2 |
| Gerstberger, R | 1 |
| Spyer, KM | 2 |
| Gourine, VN | 2 |
| Uslan, DZ | 1 |
| Jacobson, KM | 1 |
| Kumar, N | 1 |
| Berbari, EF | 1 |
| Orenstein, R | 1 |
| Croft, AM | 1 |
| Jackson, CJ | 1 |
| Friend, HM | 1 |
| Minton, EJ | 1 |
| Moore, AC | 1 |
| Ryan, ET | 1 |
| Waldron, MA | 1 |
| La Rocca, RV | 1 |
| Stein, CA | 1 |
| Danesi, R | 1 |
| Cooper, MR | 1 |
| Uhrich, M | 1 |
| Myers, CE | 1 |
Other Studies
10 other studies available for suramin and Fever
| Article | Year |
|---|---|
A veterinarian with fever, rash and chancre after holidays in Uganda.
Topics: Belgium; Female; Fever; Humans; Insect Bites and Stings; Middle Aged; Suramin; Travel; Trypanocidal | 2018 |
Trypanosoma brucei rhodesiense infection in a German traveller returning from the Masai Mara area, Kenya, January 2012.
Topics: Animals; Chancre; Diagnosis, Differential; Fever; Fluorescent Antibody Technique; Germany; Headache; | 2012 |
Human African trypanosomiasis in a Belgian traveller returning from the Masai Mara area, Kenya, February 2012.
Topics: Belgium; Chancre; Fever; Headache; Humans; Kenya; Male; Polymerase Chain Reaction; Suramin; Travel; | 2012 |
A returning traveller with fever, facial swelling, and skin lesions.
Topics: Adrenal Cortex Hormones; Animals; Diagnosis, Differential; Disease Progression; Face; Fever; Humans; | 2012 |
P2 receptor blockade attenuates fever and cytokine responses induced by lipopolysaccharide in rats.
Topics: Animals; Body Temperature; Fever; Interleukin-1; Interleukin-6; Lipopolysaccharides; Male; Purinergi | 2005 |
A woman with fever and rash after African safari.
Topics: Africa; Exanthema; Female; Fever; Humans; Melarsoprol; Middle Aged; Pentamidine; Suramin; Travel; Tr | 2006 |
African trypanosomiasis in a British soldier.
Topics: Adult; Antinematodal Agents; Chancre; Erythema; Fever; Humans; Injections; Male; Military Personnel; | 2006 |
Involvement of purinergic signalling in central mechanisms of body temperature regulation in rats.
Topics: Adenosine Triphosphate; Animals; Body Temperature Regulation; Brain; Fever; Hypothalamus; Injections | 2002 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 20-2002. A 37-year-old man with fever, hepatosplenomegaly, and a cutaneous foot lesion after a trip to Africa.
Topics: Adult; Africa; Animals; Anthrax; Blood; Cerebrospinal Fluid; Diagnosis, Differential; Erythema; Feve | 2002 |
A pilot study of suramin in the treatment of metastatic renal cell carcinoma.
Topics: Adult; Aged; Carcinoma, Renal Cell; Female; Fever; Gastrointestinal Diseases; Hematologic Diseases; | 1991 |