succinic acid has been researched along with Coma in 4 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Under modeling of thiopental coma influence of sodium succinate and (or) external warming for the support of normal body temperature (isothermal regimen) on the gas exchange, blood gas content, acid-base status and survival rate was studied in rats." | 7.73 | Succinate and artificial maintenance of normal body temperature synergistically correct lethal disorders in thiopental coma rat. ( Ivnitsky, JJ; Malakhovsky, VN; Rejniuk, VL; Schäfer, TV, 2006) |
| "Under modeling of thiopental coma influence of sodium succinate and (or) external warming for the support of normal body temperature (isothermal regimen) on the gas exchange, blood gas content, acid-base status and survival rate was studied in rats." | 3.73 | Succinate and artificial maintenance of normal body temperature synergistically correct lethal disorders in thiopental coma rat. ( Ivnitsky, JJ; Malakhovsky, VN; Rejniuk, VL; Schäfer, TV, 2006) |
| "Injection of sodium succinate in doses of 5 or 10 mmol/kg (but not 1 mmol/kg) intensified oxygen consumption in rats with sodium thiopental-induced coma." | 3.72 | Effect of sodium succinate on gas exchange in rats with barbiturate-induced coma. ( Ivnitskii, YY; Malakhovskii, VN; Shefer, TV, 2003) |
| " A condition for antidote effect of the Krebs intermediate was sufficiently high dosage (5 mmol/kg), further dose increase made no odds." | 1.32 | Intermediates of Krebs cycle correct the depression of the whole body oxygen consumption and lethal cooling in barbiturate poisoning in rat. ( Ivnitsky, JJ; Malakhovsky, VN; Rejniuk, VL; Schäfer, TV, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shefer, TV | 1 |
| Ivnitskii, YY | 1 |
| Malakhovskii, VN | 1 |
| TRAUTNER, EM | 1 |
| TRETHEWIE, ER | 1 |
| Ivnitsky, JJ | 2 |
| Schäfer, TV | 2 |
| Malakhovsky, VN | 2 |
| Rejniuk, VL | 2 |
4 other studies available for succinic acid and Coma
| Article | Year |
|---|---|
Effect of sodium succinate on gas exchange in rats with barbiturate-induced coma.
Topics: Animals; Coma; Female; Hypnotics and Sedatives; Malonates; Oxygen Consumption; Rats; Respiration; Su | 2003 |
The analeptic effect of succinate in coma and in confusional states.
Topics: Blood Pressure; Blood Pressure Determination; Central Nervous System Stimulants; Coma; Confusion; Co | 1953 |
Intermediates of Krebs cycle correct the depression of the whole body oxygen consumption and lethal cooling in barbiturate poisoning in rat.
Topics: Amobarbital; Animals; Antidotes; Body Temperature; Citric Acid Cycle; Coma; Female; Hypnotics and Se | 2004 |
Succinate and artificial maintenance of normal body temperature synergistically correct lethal disorders in thiopental coma rat.
Topics: Anesthetics, Intravenous; Animals; Blood Gas Analysis; Body Temperature; Carbon Dioxide; Coma; Femal | 2006 |