substance p has been researched along with Ache in 773 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 189 (24.45) | 18.7374 |
| 1990's | 205 (26.52) | 18.2507 |
| 2000's | 239 (30.92) | 29.6817 |
| 2010's | 114 (14.75) | 24.3611 |
| 2020's | 26 (3.36) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, ES; Ham, HD; Lee, C; Lee, CH; Lee, S; Park, JH | 1 |
| Feng, N; Han, G; Hou, X; Li, Y; Liu, W; Wu, H; Xing, B; Zhang, J | 1 |
| D'Antoni, AV; Iwanaga, J; Loukas, M; Olewnik, Ł; Saga, T; Tubbs, RS; Yilmaz, E | 1 |
| Feng, S; Mao, M; Wang, J; Wang, X; Zhang, S; Zhou, F | 1 |
| Beaudry, F; Bédard, A; Bouet, E; Delsart, A; Frezier, M; Gaumond, I; Guillot, M; Keita-Alassane, S; Lecomte, R; Lussier, B; Marchand, S; Martel-Pelletier, J; Moreau, M; Otis, C; Pelletier, JP; Troncy, E | 1 |
| Feist, M; Tschoner, T | 1 |
| Coetzee, J; Janzen, ED; Kleinhenz, MD; Marti, S; Martin, M; Melendez, D; Pajor, EA; Schwartzkopf-Genswein, KS | 1 |
| Jain, M; Joharapurkar, A; Patel, V | 1 |
| Chen, B; Hong, ZF; Liu, H; Liu, J; Xiu, ZB; Zhang, LZ; Zhao, HJ | 1 |
| Boutopoulou, B; Bozas, E; Dionysakopoulou, C; Giannakopoulou, M; Koumpagioti, D; Lianou, L; Matziou, V; Vlachioti, E | 1 |
| Huyhn, R; Jung, T; Kim, B; McKemy, DD; Yamaki, S; Yang, C | 1 |
| Guimarães, AS; Lopes, GC; Ramacciato, J; Rocha Valadas, LA; Watinaga, GK | 1 |
| Bunnett, NW; Gmeiner, P; Hegron, A; Huebner, H; Imlach, WL; Jensen, DD; Latorre, R; Peach, CJ; Poole, DP; Rientjes, J; Schmidt, BL; Seemann, P; Teng, S; Thomsen, ARB; Tonello, R; Veldhuis, NA; Weikert, D | 1 |
| Knubben-Schweizer, G; Landinger, A; Tschoner, T; Zablotski, Y | 1 |
| Bäumer, W; Fukuyama, T; Ganchingco, JRC; Yoder, JA | 1 |
| Carlsson, A; Ernberg, M; Ghafouri, B; Hedenberg-Magnusson, B; Jasim, H | 2 |
| Achuthan, A; Anderson, GP; Cook, A; Ellson, C; Feeney, M; Fleetwood, AJ; Hamilton, JA; Jarnicki, A; Lee, KM; Modis, LK; Smith, JE | 1 |
| Ding, G; Jia, L; Jiang, F; Li, J; Ouyang, X; Sun, Y; Wang, L; Wang, Y; Yang, C; Yu, R; Zhu, Z | 1 |
| Fukushige, R; Hisaoka-Nakashima, K; Kishida, Y; Morioka, N; Nakamura, Y; Nakata, Y; Watanabe, K | 1 |
| Feist, M; Knubben-Schweizer, G; Mayer, C; Rieger, A; Zablotski, Y | 1 |
| Alkan, Ö; Kaya, Y; Keskin, S; Kömüroglu, AU | 1 |
| Chen, S; Guo, Y; Song, Y; Wang, LK; Zhang, RY; Zhao, JG; Zhao, L; Zhu, BF | 1 |
| Danielsen, N; Etemadi, L; Pettersson, LME | 1 |
| Choi, JG; Kang, DW; Kim, HW; Kim, J; Lee, JH; Park, JB | 1 |
| Deng, L; Du, D; Fu, X; Han, C; Hong, J; Huang, W; Jiang, K; Jin, T; Li, J; Liu, T; Mukherjee, R; Phillips, AR; Shi, N; Sutton, R; Wang, R; Wen, Y; Windsor, JA; Xia, Q; Yang, J | 1 |
| Gilani, SA; Hanif, A; Hassan, A; Hassan, S; Mehboob, R; Tanvir, I; Waseem, H | 1 |
| Alhilou, AM; Cairns, BE; Christidis, N; Ernberg, M; Shimada, A; Svensson, CI; Svensson, P | 1 |
| Chen, YJ; Greenhill, C; Ivanusic, JJ; Kim, DH; Nencini, S; Ringuet, M | 1 |
| Heikkilä, HM; Hielm-Björkman, AK; Innes, JF; Laitinen-Vapaavuori, OM | 1 |
| Li, Z; Wang, S; Xiao, J | 1 |
| Aguirre, M; Cruz-Almeida, Y; Dasilva Ribeiro, MC; Eckert, NR; Edwards, RR; Riley, JL; Simon, CB; Sorenson, HL; Tighe, PJ; Wallet, SM | 1 |
| Arden, NK; Cicuttini, FM; Cooper, C; Dennison, EM; Doherty, M; Hart, DJ; Jones, G; Laslett, LL; Leaverton, P; Maciewicz, RA; Muir, KR; Rampersaud, E; Soni, A; Spector, TD; Valdes, AM; Walsh, DA; Warner, SC; Zhang, W | 1 |
| Aurelio, L; Barlow, N; Bunnett, NW; Canals, M; Christie, MJ; Conner, J; Escriou, V; Geppetti, P; Graham, B; Halls, ML; Herenbrink, CK; Hicks, GA; Imlach, WL; Jensen, DD; Lieu, T; Mai, QN; Materazzi, S; McCluskey, A; Nassini, R; Poole, DP; Porter, CJH; Quach, T; Robinson, PJ; Scanlon, MJ; Simpson, JS; Veldhuis, NA | 1 |
| Bai, XG; Hao, LY; Liu, L; Zheng, XH | 1 |
| de Cassia do Carmo-Campos, E; Dias, FJ; Fazan, VPS; Giorgetto, C; Silva, GAR; Simões, ALB | 1 |
| Buscaglia, P; Carré, JL; Gouin, O; L'herondelle, K; Le Gall-Ianotto, C; Lebonvallet, N; Leschiera, R; Mignen, O; Misery, L; Philbé, JL; Saguet, T; Sakka, M | 1 |
| Gellatly, D; Janzen, ED; Marti, S; Meléndez, DM; Moya, D; Pajor, EA; Schwartzkopf-Genswein, KS | 1 |
| Hong, JW; Jang, SP; Lee, HJ; Lee, JR; Park, SH; Suh, HW | 1 |
| Amagase, K; Kato, S; Matsumoto, K; Tominaga, M; Tsukahara, T; Utsumi, D | 1 |
| Demartini, C; Deseure, K; Francesconi, O; Greco, R; Nativi, C; Tassorelli, C; Zanaboni, AM | 1 |
| Bujalska-Zadrozny, M; Hermans, E; Kleczkowska, P; Nowicka, K | 1 |
| Borbély, É; Gaszner, B; Gubányi, T; Hajna, Z; Helyes, Z; Hunyady, Á; Kemény, Á; Scheich, B | 1 |
| Ahmed, AS; Alkass, K; Berg, S; Druid, H; Hart, DA; Kosek, E; Svensson, CI | 1 |
| Navratilova, E; Porreca, F | 1 |
| Björkegren, K; Burell, G; Karlsson, B; Kristiansson, P; Nyberg, F; Svärdsudd, K | 1 |
| Freitag, K; Freitag, MSC; Izquierdo, MDC; Pipis, H; Theoharides, TC; Tsilioni, I | 1 |
| Ogawa, T; Tanaka, T; Yanai, T | 1 |
| Basbaum, AI; Eberhart, D; Meda, K; Rice, D; Solorzano, C; Urban, R; Wang, X; Yamanaka, H; Zhang, J | 1 |
| Chen, T; Li, YQ; Qu, J; Wang, W; Wang, XL; Wu, SX; Yanagawa, Y; Zhang, T | 1 |
| Allen, KA; Bello, NM; Bergamasco, L; Coetzee, JF; Dockweiler, JC; Edwards-Callaway, LN; Glynn, HD; Jones, ML; Miller, KA; Theurer, ME | 1 |
| Kang, YJ; Kim, CH; Kim, SJ; Kim, SS; Lim, SM; Park, SH; Sim, YB; Suh, HW | 1 |
| Ericson, ME; Gupta, K; Gupta, M; Luk, K; Nguyen, J; Simone, DA; Vang, D; Vincent, L | 1 |
| Ma, W; Quirion, R; Shukla, M | 1 |
| Chun, J; Khan, S; Kim, YS; Shehzad, O | 1 |
| Kouchek, M; Takasusuki, T; Terashima, T; Xu, Q; Yaksh, TL | 1 |
| Chavarría-Bolaños, D; Flores-Reyes, H; Lombana, N; Martinez-Zumaran, A; Pozos-Guillen, A | 1 |
| Arora, V; Chopra, K | 1 |
| Arizpe, HM; Clifford, JL; Fowler, M; Garza, TH; Loyd, DR; Novak, J; Petz, LN; Slater, TM | 1 |
| Baek, SH; Kang, MK; Kim, HC; Lee, W; Shon, WJ; Yoo, YJ | 1 |
| Eddinger, KA; Marino, MJ; Steinauer, JJ; Terashima, T; Xu, Q; Yaksh, TL | 1 |
| Jia, MM; Li, XJ; Li, YS; Mao, XQ; Tang, HB; Yang, YL | 1 |
| Luz, LL; Safronov, BV; Szucs, P | 1 |
| Mizoguchi, H; Sakurada, S; Sakurada, T; Sato, T; Takagi, H; Watanabe, C; Yonezawa, A | 1 |
| Cook, JL; Cormick, W; Dahlstrom, JE; Fearon, AM; Scott, A; Smith, PN; Twin, J | 1 |
| Chen, W; Marvizón, JC; McRoberts, JA | 1 |
| Ahmed, AS; Ahmed, M; Bakalkin, G; Gu, HF; Harris, HE; Li, J; Stark, A | 1 |
| Coveñas, R; Muñoz, M | 1 |
| Altier, C; Benson, JR; Lapointe, TK; Lomax, AE; Moynes, DM; Vanner, SJ; Xu, J | 1 |
| Anta, B; Arévalo, JC; Calvo, L; López-Bellido, R; López-Benito, S; Rodriguez, RE; Tessarollo, L; Vicente-García, C; Yu, T | 1 |
| Choi, YH; Jang, YC; Kwak, IS; Lee, YK | 1 |
| Ebihara, K; Funahashi, H; Ikeda, T; Ishida, Y; Koganemaru, G; Kuramashi, A; Naono-Nakayama, R; Nishimori, T | 1 |
| Beaudry, F; Bertaim, T; Del Castillo, JR; Gauvin, D; Martel-Pelletier, J; Moreau, M; Otis, C; Pelletier, JP; Rialland, P; Troncy, E | 1 |
| Balla, K; Bendele, A; Bogseth, R; Gass, J; Graham, S; Hutchcraft, A; Rabinow, B; Valaitis, P; Werling, J | 1 |
| Banuelos, J; Coetzee, JF; Drake, D; Hoar, B; Mintline, EM; Stock, ML; Tucker, CB; Varga, A; Walker, KA; Weary, DM | 1 |
| Dong, YL; Li, YQ; Lu, YC; Wang, J; Wang, W; Wei, YY; Wu, HH; Wu, SX; Yin, JB; Zhang, T; Zhang, Y | 1 |
| Ding, H; Hayashida, K; Kimura, M; Ko, MC; Mendenhall, V; Sukhtankar, DD; Suto, T | 1 |
| Liu, YJ; Song, GH; Zhang, C | 1 |
| Alfredson, H; Andersson, G; Christensen, J | 1 |
| Clark, DJ; Guo, TZ; Kingery, WS; Li, WW; Shi, X; Wei, T | 1 |
| Cho, EY; Jiang, W; Sha, O; Wu, H; Zeng, M | 1 |
| Barth, LA; Coetzee, JF; Gehring, R; Hsu, WH; Millman, ST; Parsons, RL; Stock, ML; Van Engen, NK; Wang, C | 1 |
| Jiang, Y; Li, G; Liu, J; Ma, Y; Tian, S; Tian, Y; Yan, L; Zhou, C | 1 |
| Cerda-Cristerna, B; Chavarria-Bolaños, D; Flores-Reyes, H; Lombana-Sanchez, N; Pozos-Guillen, A | 1 |
| Cho, SK; Hecht, AC; Iatridis, JC; Lai, A; Laudier, DM; Moon, A; Purmessur, D; Skovrlj, B; Winkelstein, BA | 1 |
| Rebora, A | 1 |
| Hamity, MV; Hammond, DL; Li, Y; Maduka, UP; Walder, RY; White, SR | 1 |
| Endo, Y; Nemoto, W; Shima, K; Sugawara, S; Takano-Yamamoto, T; Tan-No, K; Tsuchiya, M | 1 |
| Borbély, É; Helyes, Z; Kemény, Á; Markovics, A; McDougall, JJ; Pintér, E; Quinn, JP; Sándor, K; Szolcsányi, J | 1 |
| Douglas, SD | 2 |
| Cai, X; Cohen, J; Huang, H; Kaplan, DH; Kuzirian, MS; Ross, SE; Snyder, LM | 1 |
| de Oliveira Borges, M; Fischer, L; Lavoranti, MI; Martynhak, BJ; Miksza, AF; Parada, CA; Sardi, NF; Tambeli, CH | 1 |
| Borbély, É; Helyes, Z | 1 |
| Arisi, I; Brandi, R; Bruni, B; Calissano, P; Cattaneo, A; Ciotti, MT; D'Onofrio, M; Florenzano, F; Malerba, F; Petrella, C; Petrocchi Passeri, P; Possenti, R; Severini, C | 1 |
| Funahashi, H; Igawa, K; Ishida, Y; Matsuo, H; Miyahara, Y; Naono-Nakayama, R; Nishimori, T; Sakoda, S; Yamashita, Y | 1 |
| Apley, MD; Coetzee, JF; Gehring, R; Lubbers, BV; Thomson, DU; Toerber, SE; White, BJ | 1 |
| Jesse, CR; Nogueira, CW; Savegnago, L | 1 |
| Bartolomucci, A; Ciotti, MT; D'Amato, F; La Corte, G; Levi, A; Moles, A; Pavone, F; Possenti, R; Rizzi, R; Sacerdote, P | 1 |
| Dafre, AL; Farina, M; Jacques, AV; Mendes, BG; Meotti, FC; Nascimento, FP; Pizzolatti, MG; Ribas, CM; Rodrigues, AL; Santos, AR; Soldi, C | 1 |
| Crawley, B; Fitzsimmons, B; Hua, XY; Malkmus, S; Saito, O; Yaksh, TL | 1 |
| Christianson, CA; Hua, XY; Nazarian, A; Yaksh, TL | 1 |
| Camargo, Lde L; Costa, SK; Denadai-Souza, A; Keeble, JE; Muscará, MN; Ribela, MT | 1 |
| Ikeda, T; Matsushima, O; Nakayama, T; Naono, R; Nishimori, T | 2 |
| Dableh, LJ; Henry, JL; Yashpal, K | 1 |
| Al-Khater, KM; Polgár, E; Shehab, S; Todd, AJ; Watanabe, M | 1 |
| Birklein, F; He, L; Krämer, HH; Lu, B; Sommer, C | 1 |
| Bodfish, JW; Heeth, W; Kennedy, W; Symons, FJ; Wendelschafer-Crabb, G | 1 |
| Hubbard, RD; Martínez, JJ; Quinn, KP; Winkelstein, BA | 1 |
| Lee, KE; Winkelstein, BA | 1 |
| Bach, FW; Jensen, TS; Terkelsen, AJ | 1 |
| Kai, M; Kawashima, K; Misawa, H; Miyazawa, M; Moriwaki, Y; Okuda, T; Shinagawa, T; Waguri, S; Watanabe, Y; Yabashi, A | 1 |
| Barbe, MF; Barr, AE; Elliott, MB | 1 |
| Chen, ZF; Drobish, JK; Gereau, RW; Gracias, NG; Sun, YG; Vasko, MR | 1 |
| Antonelli, A; Barone, G; Chiaretti, A; Genovese, O; Lazzareschi, I; Maurizi, P; Paiano, S; Riccardi, R; Ruggiero, A; Sammartino, M | 1 |
| Fekete, C; Kozsurek, M; Lukácsi, E; Puskár, Z | 1 |
| Hammond, DL; Zhang, L | 1 |
| Iwata, Y; Komatsu, T; Kuwahata, H; Sakurada, C; Sakurada, S; Sakurada, T; Sanai, K; Sasaki, M; Tsuzuki, M | 1 |
| Basbaum, AI; Cao, YQ; Contet, C; Imamachi, N; Kieffer, BL; Mennicken, F; O'Donnell, D; Scherrer, G | 1 |
| Katsuyama, S; Kohno, K; Komatsu, T; Sakurada, C; Sakurada, S; Sakurada, T; Shiohira, H; Tsuzuki, M | 1 |
| Katsuyama, S; Komatsu, T; Sakurada, S; Sakurada, T; Sanai, K | 1 |
| Seybold, VS | 1 |
| Ahn, KS; Kim, KH; Kim, SH; Lee, CH; Lee, EO; Lee, HJ; Lee, JH; Lee, KS; Nam, DW | 1 |
| Higashi, M; Moriya, H; Nakagawa, K; Ogino, S; Sasho, T; Suzuki, M; Takahashi, K; Yamaguchi, S | 1 |
| Chang, YW; Saab, C; Tan, A; Waxman, S | 1 |
| Ackermann, G; Babilas, P; Karrer, S; Landthaler, M; Schreml, S; Steinbauer, J; Szeimies, RM | 1 |
| Bhatia, M | 1 |
| Bunnett, NW; Cattaruzza, F; Grady, EF; Miranda-Morales, M; Spreadbury, I; Vanner, S | 1 |
| Hamity, MV; Hammond, DL; White, SR | 1 |
| Ahn, DK; Bae, YC; Dai, Y; Kim, TH; Kim, YS; Noguchi, K; Paik, SK; Son, JY | 1 |
| Chen, W; Lao, L; Marvizón, JC; Zhang, G | 1 |
| Chan, KM; Chan, LS; Fu, SC; Lui, PP | 1 |
| Chen, ZW; Li, LK; Li, WB; Liu, LM; Lu, GS; Pan, JH; Song, B; Xiong, EQ; Yang, Z; Zhang, H; Zhang, JH; Zhou, ZS | 1 |
| Ericson, ME; Gupta, K; Gupta, P; Gupta, V; Hebbel, RP; Kehl, LJ; Khasabov, SG; Kohli, DR; Li, Y; Nguyen, J; Simone, DA | 1 |
| Arshad, M; Arshad, N; Iqbal, R; Mughal, MS | 1 |
| Ciruela, F; Fernández-Dueñas, V; Gandía, J; Planas, E; Poveda, R; Sánchez, S | 1 |
| Mizoguchi, H; Sakurada, S; Watanabe, C; Yonezawa, A | 1 |
| Ahmed, AS; Ahmed, M; Bakalkin, G; Hua, L; Li, J; Ossipov, MH; Stark, A; Yakovleva, T | 1 |
| Chaban, VV | 1 |
| Berner, J; Bilkei-Gorzo, A; Racz, I; Wickström, R; Zimmer, A; Zimmermann, J | 1 |
| Boyle, EM; Laing, IA; McIntosh, N; Smith, J; Stenson, BJ; Stephen, RI; Wong, CM | 1 |
| Baker, SJ; Bianchi, BR; Faltynek, CR; Gauvin, DM; Han, P; Honore, P; Joshi, SK; Koenig, JR; Kort, ME; Kym, PR; Lewis, GR; Mikusa, JP; Neelands, TR; Perner, RJ; Puttfarcken, PS; Reilly, RM | 1 |
| Back, W; de Grauw, JC; L'ami, JJ; van Dierendonck, M; van Loon, JP; van Weeren, PR | 1 |
| Csillik, B; Knyihár-Csillik, E; Mihály, A | 1 |
| Antal, M; Holló, K; Papp, I | 1 |
| Nakagawa, H; Yano, C | 1 |
| Dubois, D; Gendron, L | 1 |
| Appenzeller, M; Bigliardi, P; Buclin, T; Grouzmann, E; Pannatier, A | 1 |
| Held-Feindt, J; Knerlich-Lukoschus, F; Lucius, R; Mehdorn, HM; von der Ropp-Brenner, B | 1 |
| Abrahamsen, B; Kullander, K; Lagerström, MC; Lind, AL; Mendez, JA; Olund, C; Rogoz, K; Smith, C; Wallén-Mackenzie, Å; Wood, JN | 1 |
| Jung, JS; Kang, YJ; Kim, SM; Lee, JK; Park, SH; Sim, YB; Suh, HW | 1 |
| Komatsu, T; Mizoguchi, H; Sakurada, C; Sakurada, S; Sakurada, T; Sasaki, M; Tsuzuki, M | 1 |
| LeRoy, P | 1 |
| Liu, L; Pasricha, PJ; Shenoy, M | 1 |
| Anderson, MB; Hoffman, EM; Miller, KE; Schechter, R; Zhang, Z | 1 |
| Grzegorzewski, A; Jóźwiak, M; Masłoń, A; Modrzewski, T; Pawlak, M | 1 |
| Beaudry, F; Ferland, CE; Pailleux, F; Vachon, P | 1 |
| Beaudry, H; Dubois, D; Gendron, L | 1 |
| Chen, JC; Lin, YT; Ro, LS; Wang, HL | 1 |
| Ahmed, AS; Ahmed, M; Bakalkin, G; Erlandsson-Harris, H; Li, J; Stark, A | 1 |
| Akasaka, Y; Hatta, A; Inoue, H; Sakai, A; Suzuki, H; Takasu, K; Tsukahara, M | 1 |
| Aubdool, AA; Brain, SD | 1 |
| Gustafsson, L; Ingemansson, R; Lindstedt, S; Malmsjö, M | 1 |
| Jia, MM; Li, XJ; Li, YS; Liu, M; Tang, HB; Wang, JX | 1 |
| Aricò, G; Parenti, C; Ronsisvalle, G; Scoto, GM | 1 |
| Li, J; Xu, SL; Yu, LC; Zhang, JJ | 1 |
| Li, H; Li, YQ; Luo, Y; Sun, ZS; Teng, H; Zhang, J; Zhang, T; Zhao, M | 1 |
| Clark, JD; Li, WW; Li, XQ; Liang, DY; Sahbaie, P; Shi, XY; Sun, Y | 1 |
| Coetzee, JF; Gehring, R; KuKanich, B; Mosher, RA; Reinbold, JB; Robert, B; White, BJ | 1 |
| Chen, Y; Gui, Q; Peng, P; Xia, S; Xu, C; Yu, S; Zhuang, L | 1 |
| Carstens, E; Gogineni, AG; Iodi Carstens, M; Simons, CT | 1 |
| Cai, Y; Evensjö, M; Kovács, KJ; Larson, AA; McCarson, KE; Shi, Q; Velázquez, RA | 1 |
| Chen, LW; Ding, YQ; Ju, G; Lu, CR; Su, CJ; Wang, H; Zhang, YQ | 1 |
| Kyrkanides, S; Macher, DJ; Olschowka, JA; Stevens, SY; Tallents, RH | 1 |
| Geisslinger, G; Meller, ST; Tegeder, L; Zimmermann, J | 1 |
| Conrath, M; Cottone, E; Franzoni, MF; Salio, C | 1 |
| Cunningham, J; Gavazzi, I; Grist, J; Lever, IJ; Malcangio, M; Patel, J; Pezet, S | 1 |
| Biedert, RM; Sanchis-Alfonso, V | 1 |
| Boscan, P; Kasparov, S; Paton, JF | 1 |
| Dickenson, AH; Hunt, SP; Morcuende, S; Suzuki, R; Webber, M | 1 |
| Ishida, Y; Murakami, S; Shimada, S; Ueda, T; Ugawa, S | 1 |
| Dun, NJ; Hua, F; Ricketts, BA; Williams, CA | 1 |
| Huang, W; Tuckett, RP; Zhang, J | 1 |
| Feng, YP; Li, YQ; Yang, K | 1 |
| Clohisy, DR; Mantyh, PW | 1 |
| Lu, Y; Vera-Portocarrero, LP; Westlund, KN | 1 |
| Calo, G; Inoue, A; Inoue, M; Kawashima, T; Nakata, Y; Takeshima, H; Ueda, H | 1 |
| Lafforgue, P; Pham, T | 1 |
| Aman, K; Carlstedt, T; Dostrovsky, J; Hökfelt, T; Josephson, A; Landry, M; Lozano, AM; Spenger, C; Wiesenfeld-Hallin, Z | 1 |
| Boudah, A; Jasmin, L; Ohara, PT | 1 |
| Inoue, M; Kawashima, T; Kishioka, S; Maeda, T; Matsumoto, M; Rashid, MH; Ueda, H | 1 |
| Choi, SS; Han, EJ; Han, KJ; Kim, DH; Lee, HK; Lee, JK; Suh, HW | 1 |
| Iadarola, MJ; Lonser, RR; Morrison, PF; Sarntinoranont, M | 1 |
| Boscan, P; Paton, JF; Pickering, AE | 1 |
| Blisnick, T; Desor, D; Dugave, C; Hermitte, V; Messaoudi, M; Rigault, AG; Rougeon, F; Rougeot, C | 1 |
| Boncz, I; Csillik, B; Janka, Z; Kálmán, J; Knyihár, E; Mihály, A; Vécsei, L | 1 |
| Carol, A; Comer, C; Hong, HS; Lu, Y; Park, TJ; Rice, FL | 1 |
| Hwang, SJ; Valtschanoff, JG | 1 |
| Choi, SS; Han, EJ; Han, KJ; Lee, HK; Suh, HW | 2 |
| Dreyer, J; Hirlinger, D; Kuner, R; Müller-Esterl, W; Oess, S | 1 |
| GUZMAN, F; LIM, RK; POTTER, GD | 1 |
| He, ZJ; Micci, MA; Pasricha, PJ; Shenoy, M; Toma, H; Winston, JH; Xiao, SY; Zou, L | 1 |
| Balzarini, P; Baratelli, E; Bianchi, M; Broggini, M; Ferrario, P; Panerai, AE; Sacerdote, P | 1 |
| Horie, H; Imbe, H; Kadoya, T; Okamoto, K; Senba, E | 1 |
| Burnstock, G; Csermely, P; Greensmith, L; Kalmar, B; Malcangio, M; McMahon, SB | 1 |
| Lund, I; Lundeberg, T; Rosén, A; Yu, LC; Zhang, YX | 1 |
| Del Turco, D; Deller, T; Feil, R; Geisslinger, G; Hofmann, F; Ruth, P; Sausbier, M; Schmidtko, A; Tegeder, I | 1 |
| Bonney, I; Carr, DB; Marchand, JE; Sant, GR; Sukiennik, A; Wurm, H | 1 |
| Fujimoto, JM; Leitermann, RJ; Sun, HS; Thompson, J; Tseng, LF; Wu, HE | 1 |
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| Belmonte, C; Cervero, F; De Felipe, C; Doyle, CA; Herrero, JF; Hunt, SP; Laird, JM; O'Brien, JA; Palmer, JA; Smith, AJ | 1 |
| Carlton, SM; Coggeshall, RE; Zhou, S | 1 |
| Elde, R; Olson, TH; Ortiz-Gonzalez, XR; Riedl, MS; Vulchanova, L | 1 |
| Cerinic, MM; Cutolo, M; Generini, S; Konttinen, Y | 1 |
| Boden, P; Field, MJ; Hughes, J; McCleary, S; Singh, L; Suman-Chauhan, N | 1 |
| Choi, HS; Kim, SK; Nah, JJ; Nah, SY; Nam, KY; Shin, YH; Yoon, SR | 1 |
| Ishii, S; Usui, M; Yamashita, T | 1 |
| Mannion, RJ; Neumann, S; Woolf, CJ | 1 |
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| Buffington, CA; Wolfe, SA | 1 |
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| Pasternak, GW | 1 |
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| Douglas, SD; Michaels, LA; Ohene-Frempong, K; Zhao, H | 1 |
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| Fukuda, H; Gotoh, M; Hamada, K; Inoue, A; Yamakawa, H | 1 |
| Ennes, HS; Eskandari, S; Marvizón, JC; Mayer, EA | 1 |
| Asai, T; Ikeda, H; Murase, K; Saka, T; Terao, S | 1 |
| Alvarez-Vega, M; Baamonde, A; Gutiérrez, M; Hidalgo, A; Menéndez, L | 1 |
| Ackenheil, M; Bondy, B; Müller-Bardorff, H; Pongratz, DE; Schwarz, MJ; Späth, M | 1 |
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| Abbadie, C; Basbaum, AI; Mantyh, PW; Marchand, S; Trafton, JA | 1 |
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| Krause, JE; McLeod, AL; Ribeiro-Da-Silva, A | 1 |
| Ito, S; Minami, T; Mishina, M; Mori, H; Okuda-Ashitaka, E; Sakimura, K; Watanabe, M | 1 |
| Beinborn, M; Carr, DB; Foran, SE; Kopin, AS; Kream, RM; Lipkowski, AW; Marchand, JE; Maszczynska, I; Misicka, A | 1 |
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| Fried, K; Lindqvist, A; Rivero-Melian, C; Turan, I | 1 |
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| Crul, BJ; Dirksen, R; Slappendel, R; Snijdelaar, DG | 1 |
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| Li, H; Li, YQ | 1 |
| Cooper, BY; Gu, JG; Johnson, RD; Napaporn, J; Petruska, JC | 1 |
| Kaneko, T; Li, H; Li, YQ; Mizuno, N; Wang, ZM; Yang, K | 1 |
| Honoré, P; Mantyh, PW; Menning, PM; Nichols, ML; Rogers, SD | 1 |
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| Li, YQ; Shi, JW; Yang, K; Zhang, YH | 1 |
| Amadesi, S; Bunnett, NW; Chaban, VV; Coutinho, SV; Creminon, C; Ennes, HS; Geppetti, P; Grady, EF; Lanthorn, T; Marvizón, JC; Mayer, EA; McRoberts, JA; Sengupta, JN; Tognetto, M | 1 |
| Choi, SS; Chung, KM; Lee, KC; Suh, HW | 1 |
| Andrade-Gordon, P; Basbaum, AI; Brussee, V; Bunnett, NW; Cirino, G; Compton, SJ; Gerard, N; Grady, EF; Hollenberg, MD; Sharkey, KA; Vergnolle, N; Wallace, JL | 1 |
| Guo, A; Hwang, SJ; Rustioni, A; Valtschanoff, JG | 1 |
| Ackley, MA; Asghar, AU; King, AE; Worsley, MA | 1 |
| Holden, JE; Naleway, E | 1 |
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| Kaneko, T; Li, H; Li, JL; Li, YQ; Mizuno, N | 1 |
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| Kaneko, T; Li, JL; Li, YQ; Mizuno, N; Nomura, S | 1 |
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| Choi, SS; Lee, JK; Suh, HW | 1 |
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| Han, HC; Han, JS; Hong, SK; Hwang, JM; Kim, YI; Min, SS; Na, HS; Yoon, YW | 1 |
| Commons, KG; Valentino, RJ | 1 |
| Puskár, Z; Sakamoto, H; Spike, RC; Stewart, W; Todd, AJ; Watt, C | 1 |
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| Bourgoin, S; Cesselin, F; Hamon, M; Mauborgne, A; Poliénor, H | 1 |
| Hanesch, U; Nitz, C; Pawlak, M; Schmidt, RF | 1 |
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| Greenberg, S; Palmer, GC | 1 |
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| Elde, R; Hökfelt, T; Ljungdahl, A; Nilsson, G; Terenius, L | 1 |
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| Miletić, V; Randić, M | 1 |
| Getto, CJ; Krivoy, WA; Neldner, K; Reeve, EB; Stewart, JM; Zimmermann, E | 1 |
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| Aoki, T; Hitosugi, H; Kamei, J; Kasuya, Y; Kawashima, N; Ohhashi, Y | 1 |
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| Beger, HG; Bockman, E; Büchler, M; Friess, H; Malfertheiner, P; Müller, S; Nohr, D; Weihe, E | 1 |
| Kawakami, M; Tamaki, T | 1 |
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| Du, J; He, L | 1 |
| Kawamura, M; Kuraishi, Y; Satoh, M | 1 |
| Proudfit, HK; Yeomans, DC | 1 |
| Eide, PK | 1 |
| Adler, MW; Liu-Chen, LY; Tiseo, PJ | 1 |
| Inoki, R; Ohkubo, T; Shibata, M; Takahashi, H | 3 |
| Kamei, J; Kasuya, Y; Ogawa, M | 1 |
| Inoki, R | 2 |
| Skerrett, PJ | 1 |
| Bladon, CM; El-Yassir, N; Fleetwood-Walker, SM; Hope, PJ; Mitchell, R; Molony, V | 1 |
| Larson, AA; Skilling, SR; Smullin, DH | 1 |
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| Carr, DB; Lipkowski, AW | 1 |
| Feng, DM; Folkers, K; Håkanson, R; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Hayes, RL; Kellstein, DE; Mayer, DJ; Price, DD | 1 |
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| Li, H; Li, X; Ruan, H; Yuan, H | 1 |
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| Chorev, M; Devor, M; Gilon, C; Papir-Kricheli, D; Selinger, Z | 1 |
| Brody, MJ; Gebhart, GF; Lewis, SJ; Meller, ST; Ness, TJ | 1 |
| Casey, SJ; Gaumann, DM; Grabow, TS; Rodriguez, M; Yaksh, TL | 1 |
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| Eide, PK; Hole, K | 2 |
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| Li, H; Li, X; Liu, Z; Ruan, H; Zhao, B | 1 |
| Blomqvist, A; Ericson, AC; Le Grevés, P; Meyerson, BJ | 1 |
| Handwerker, HO; Heyer, G; Hornstein, OP | 1 |
| Aoki, T; Kamei, J; Kasuya, Y; Ohhashi, Y | 1 |
| Büchler, M; Friess, H; Müller, S; Nohr, D; Weihe, E; Zentel, HJ | 1 |
| Amann, R; Donnerer, J; Lembeck, F | 1 |
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| Coombs, DW; Deleo, JA | 1 |
| Fujita, H; Kawabata, S; Kuraishi, Y; Matsumoto, T; Nakamura, A; Satoh, M | 1 |
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| Liubimova, ZV; Marinova, TIu; Nikitina, AA; Subrakova, SA | 1 |
| Henry, JL; Radhakrishnan, V | 1 |
| Albe-Fessard, D; Iwayama, K; Kurihara, M; Mori, K; Niwa, M; Tasker, RR; Yamashiro, K | 1 |
| Goldstein, BD; McCarson, KE | 2 |
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| Couture, R; Escher, E; Henry, JL; Regoli, D; Yashpal, K | 1 |
| Basbaum, AI; Levine, JD; Moskowitz, MA | 1 |
| Sicuteri, F | 1 |
| Hara, A; Kisara, K; Matsumura, H; Sakurada, S; Sakurada, T | 1 |
| Almay, BG; Johansson, F; Sakurada, T; Terenius, L; von Knorring, L | 1 |
| Paulsson, I; Post, C | 1 |
| Ai, MK; Arakawa, K; Guan, XM; Naftchi, NE; Vacca-Galloway, LL | 1 |
| Schon, F | 1 |
| Fasmer, OB; Hole, K; Hunskaar, S | 1 |
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| Gillman, MA; Lichtigfeld, FJ | 1 |
| Hirota, N; Kaneko, S; Kuraishi, Y; Sato, Y; Satoh, M; Takagi, H | 1 |
| Görne, RC; Hecht, K; Hilse, H; Oehme, P | 1 |
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| Han, JS; Xie, GX; Zhou, ZF | 1 |
| Ji, CF; Li, CY; Zhu, LX | 2 |
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| Coderre, TJ; Melzack, R | 1 |
| Hwang, AS; Wilcox, GL | 1 |
| Brodin, E; Linderoth, B; Meyerson, BA | 1 |
| Blinn, JR; Dobry-Schreur, PJ; Moon, MW; Piercey, MF | 1 |
| Gamse, R; Saria, A | 1 |
| Herman, ZS | 1 |
| Goldstein, BD; Kantner, RM; Kirby, ML | 1 |
| Inoki, R; Shibutani, T; Tsai, HY; Yonehara, N | 1 |
| Abrams, GM; Recht, LD | 1 |
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| Fujii, N; Oku, R; Otaka, A; Satoh, M; Takagi, H; Yajima, H | 1 |
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96 review(s) available for substance p and Ache
| Article | Year |
|---|---|
Substance P concentrations in the blood plasma and serum of adult cattle and calves during different painful procedures and conditions - a systematic review.
Topics: Animals; Biomarkers; Cattle; Horns; Hydrocortisone; Pain; Plasma; Substance P | 2022 |
Therapeutic Potential of Diacerein in Management of Pain.
Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cytokines; Glutamates; Histamine; Humans; Matrix Metalloproteinases; Nitric Oxide; Osteoarthritis; Pain; Prostaglandins; Substance P; Transient Receptor Potential Channels | 2022 |
Neurokinin-1 receptor-based bivalent drugs in pain management: The journey to nowhere?
Topics: Analgesics; Animals; Humans; Ligands; Pain; Receptors, Neurokinin-1; Substance P | 2019 |
Involvement of substance P and the NK-1 receptor in human pathology.
Topics: Alcoholism; Animals; Bacterial Infections; Depression; Humans; Inflammation; Migraine Disorders; Neoplasms; Pain; Receptors, Neurokinin-1; Seizures; Stress, Psychological; Substance P; Virus Diseases; Vomiting | 2014 |
The Origin, Expression, Function and Future Research Focus of a G Protein-coupled Receptor, Mas-related Gene X2 (MrgX2).
Topics: Adrenomedullin; Cell Degranulation; Dextrorphan; Evolution, Molecular; Ganglia, Sensory; Gene Expression Regulation; Humans; Mast Cells; Nerve Tissue Proteins; Neuropeptides; Nociception; Pain; Protein Isoforms; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Signal Transduction; Substance P; Vasoactive Intestinal Peptide | 2015 |
Trichodynia: a review of the literature.
Topics: Alopecia; Humans; Pain; Scalp; Sex Factors; Substance P | 2016 |
Role of hemokinin-1 in health and disease.
Topics: Animals; Humans; Inflammation; Pain; Receptors, Neurokinin-1; Signal Transduction; Substance P; Tachykinins | 2017 |
Mechanism of allodynia evoked by intrathecal morphine-3-glucuronide in mice.
Topics: Animals; Astrocytes; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Injections, Spinal; Mice; Morphine Derivatives; Nitric Oxide; Pain; Spinal Cord; Substance P | 2009 |
The role of peptides in central sensitization.
Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Central Nervous System; Chronic Disease; Gene Expression Regulation; Humans; Hyperalgesia; Ligands; Neurons; Pain; Pain Threshold; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Transcription Factors | 2009 |
Hydrogen sulfide and substance P in inflammation.
Topics: Air Pollutants; Amino Acid Sequence; Animals; Humans; Hydrogen Sulfide; Inflammation; Inflammation Mediators; Molecular Sequence Data; Pain; Pancreatitis; Receptors, Neurokinin-1; Sepsis; Substance P; Syndrome; Systemic Inflammatory Response Syndrome | 2010 |
Pathophysiology and antioxidant status of patients with fibromyalgia.
Topics: Animals; Antioxidants; Fatigue Syndrome, Chronic; Fibromyalgia; Humans; Hypothalamo-Hypophyseal System; Mice; Oxidative Stress; Pain; Pituitary-Adrenal System; Reactive Nitrogen Species; Reactive Oxygen Species; Substance P | 2011 |
Neurovascular aspects of skin neurogenic inflammation.
Topics: Animals; Ankyrins; Calcitonin Gene-Related Peptide; Dermatitis; Dogs; Female; Haplorhini; Humans; Male; Mice; Neurogenic Inflammation; Pain; Peptide Hydrolases; Rats; Rosacea; Sex Factors; Skin; Substance P; TRPV Cation Channels | 2011 |
Sources of anterior knee pain.
Topics: Adipose Tissue; Cartilage, Articular; Humans; Knee Joint; Leg Bones; Nerve Endings; Nerve Fibers; Pain; Substance P; Synovial Membrane | 2002 |
[Analgesic mechanisms of noradrenaline in the spinal dorsal horn].
Topics: Analgesics; Animals; Humans; Nociceptors; Norepinephrine; Pain; Posterior Horn Cells; Spinal Cord; Substance P; Synaptic Transmission | 2001 |
Reflex sympathetic dystrophy syndrome and neuromediators.
Topics: Calcitonin Gene-Related Peptide; Humans; Neurogenic Inflammation; Neuropeptide Y; Neuropeptides; Pain; Reflex Sympathetic Dystrophy; Substance P; Sympathetic Nervous System; Syndrome | 2003 |
Potential therapeutic targets for neurokinin-1 receptor antagonists.
Topics: Analgesics; Anti-Anxiety Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Antiemetics; Antineoplastic Agents; Antitussive Agents; Anxiety; Asthma; Clinical Trials as Topic; Cough; Cystitis; Depression; Drug Design; Humans; Inflammation; Irritable Bowel Syndrome; Neoplasms; Neurokinin-1 Receptor Antagonists; Pain; Substance P; Vomiting | 2004 |
Advances in analgesic drug design and delivery: a current survey.
Topics: Analgesics; Drug Delivery Systems; Drug Design; Enkephalins; Humans; Microspheres; Narcotics; Pain; Polymers; Substance P | 2004 |
Selective and combined neurokinin receptor antagonists.
Topics: Animals; Central Nervous System Diseases; Drug Combinations; Gastrointestinal Diseases; Humans; Lung Diseases; Neurokinin A; Neurokinin B; Pain; Receptors, Tachykinin; Substance P; Urologic Diseases; Vomiting | 2005 |
[Involvement of N-type calcium channels in pain and antinociception].
Topics: Animals; Calcium Channels, N-Type; Ganglia, Spinal; Glutamic Acid; Humans; Nociceptors; Pain; Pain Threshold; Substance P | 2005 |
Mechanisms of nociception evoked by intrathecal high-dose morphine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Glutamic Acid; Humans; Injections, Spinal; Morphine; Nitric Oxide; Pain; Rats; Spinal Cord; Substance P | 2005 |
[Substance P].
Topics: Arthritis, Rheumatoid; Biomarkers; Diagnostic Techniques, Endocrine; Humans; Immunoenzyme Techniques; Mood Disorders; Pain; Reagent Kits, Diagnostic; Respiratory Tract Diseases; Shock, Septic; Specimen Handling; Substance P | 2005 |
Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P.
Topics: Afferent Pathways; Animals; Humans; Neural Inhibition; Nociceptors; Pain; Posterior Horn Cells; Presynaptic Terminals; Receptors, Neurokinin-1; Spinal Nerve Roots; Substance P; Synaptic Transmission | 2005 |
Neuropeptide and kinin antagonists.
Topics: Analgesics, Non-Narcotic; Animals; Animals, Genetically Modified; Calcitonin Gene-Related Peptide Receptor Antagonists; Humans; Kinins; Neurokinin-1 Receptor Antagonists; Neuropeptides; Pain; Receptors, Neurokinin-1; Substance P | 2007 |
TRP channels as novel players in the pathogenesis and therapy of itch.
Topics: Animals; Cannabinoids; Capsaicin; Central Nervous System; Histamine; Humans; Inflammation Mediators; Nerve Growth Factors; Neurons; Neurons, Afferent; Neuropeptides; Pain; Pruritus; Spinal Cord; Substance P; Temperature; Transient Receptor Potential Channels; TRPV Cation Channels | 2007 |
From neuroanatomy to gene therapy: searching for new ways to manipulate the supraspinal endogenous pain modulatory system.
Topics: Animals; Genetic Therapy; Humans; Medulla Oblongata; Pain; Pain Management; Receptors, Opioid; Substance P | 2007 |
Substance P and its receptors in bone metabolism.
Topics: Animals; Axons; Bone and Bones; Fractures, Bone; Humans; Male; Osteoporosis; Pain; Rats; Receptors, Neurokinin-1; Substance P | 2007 |
[Neurologic inflammation and oral disease. An aetiopathogenic hypothesis].
Topics: Animals; Disease Models, Animal; Disease Progression; Humans; Microcirculation; Mouth Diseases; Mouth Mucosa; Neurogenic Inflammation; Neuropeptides; Nociceptors; Pain; Rats; Substance P; Swine; Tongue; Vasoactive Intestinal Peptide | 2007 |
Substance P receptor-expressing dorsal horn neurons: lessons from the targeted cytotoxin, substance P-saporin.
Topics: Animals; Gene Expression Regulation; Humans; Immunotoxins; Pain; Posterior Horn Cells; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Substance P | 2008 |
Physiological and pharmacological investigations on pain control.
Topics: Afferent Pathways; Humans; Nerve Fibers; Nerve Fibers, Myelinated; Nociceptors; Pain; Receptors, Opioid; Spinothalamic Tracts; Substance P; Synapses; Synaptic Transmission | 1984 |
The involvement of trigeminal substance P neurons in cluster headache. An hypothesis.
Topics: Animals; Carotid Arteries; Cats; Cerebrovascular Circulation; Cluster Headache; Dilatation, Pathologic; Ganglia, Autonomic; Humans; Male; Neurons; Pain; Substance P; Sweating; Trigeminal Nerve; Vascular Headaches | 1984 |
Neurophysiological effects of capsaicin.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Capsaicin; Cardiovascular System; Cell Membrane; Digestive System; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Nerve Fibers; Nervous System; Nociceptors; Pain; Rats; Receptors, Opioid; Substance P | 1984 |
[Biologically active peptides: known compounds--new aspects. 2: Functions--general principles].
Topics: Animals; Body Temperature Regulation; Cholecystokinin; Digestive System Physiological Phenomena; Endorphins; Female; Growth; Lactation; Neurotensin; Pain; Peptides; Pregnancy; Reproduction; Sincalide; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1984 |
Physiological and psychological explanations for the mechanism of acupuncture as a treatment for chronic pain.
Topics: Acupuncture Therapy; Animals; Chronic Disease; Electric Stimulation Therapy; Endorphins; Humans; Hypnosis; Nervous System; Pain; Pain Management; Periaqueductal Gray; Placebos; Raphe Nuclei; Rats; Reflex; Substance P; Thalamus | 1984 |
[The fibrositis syndrome (author's transl)].
Topics: Adult; Behavior Therapy; Chlorpromazine; Edema; Endorphins; Female; Fibromyalgia; Humans; Male; Middle Aged; Neurotic Disorders; Obesity; Pain; Pain Management; Sleep Wake Disorders; Substance P; Syndrome; Tryptophan | 1980 |
An enkephalinergic gating system involved in nociception?
Topics: Animals; Endorphins; Enkephalins; Glutamates; Naloxone; Neurons; Pain; Spinal Cord; Substance P; Substantia Gelatinosa | 1980 |
Pharmacology of pain and analgesia.
Topics: Amino Acids; Analgesia; Electric Stimulation; Endorphins; Enkephalins; gamma-Aminobutyric Acid; Narcotics; Nerve Fibers; Neurons, Afferent; Norepinephrine; Pain; Serotonin; Substance P; Synaptic Transmission | 1980 |
The role of substance P in sensory transmission and pain perception.
Topics: Animals; Capsaicin; Ganglia, Spinal; Membrane Potentials; Neurons, Afferent; Neurotransmitter Agents; Pain; Substance P | 1981 |
Neuroendocrinology and brain peptides.
Topics: Adrenocorticotropic Hormone; Animals; Appetite; Brain; Brain Chemistry; Brain Mapping; Cerebrovascular Circulation; Cholecystokinin; Enkephalins; Humans; Memory; Mesencephalon; Mice; Neural Pathways; Pain; Peptides; Rats; Spinal Cord; Substance P; Vasoactive Intestinal Peptide; Vasopressins | 1980 |
Biochemical mediators in pain.
Topics: Antidepressive Agents; Bradykinin; Endorphins; Histamine; Humans; Nociceptors; Pain; Prostaglandins; Serotonin; Substance P | 1981 |
Relation of substance P to pain transmission: neurophysiological evidence.
Topics: Analgesia; Animals; Brain Stem; Denervation; Electrophysiology; Endorphins; Humans; Motor Neurons; Neurons; Neurons, Afferent; Nociceptors; Pain; Substance P; Synapses; Synaptic Transmission | 1982 |
If substance P fails to fulfil the criteria as a neurotransmitter in somatosensory afferents, what might be its function?
Topics: Action Potentials; Animals; Biological Transport; Capsaicin; Electric Stimulation; Hot Temperature; Models, Biological; Nerve Crush; Neurons, Afferent; Pain; Peripheral Nerve Injuries; Peripheral Nerves; Sensory Receptor Cells; Spinal Cord; Substance P; Synaptic Transmission | 1982 |
Neuropeptides and their role in pain and analgesia.
Topics: Analgesia; Angiotensin II; Bombesin; Bradykinin; Cholecystokinin; Endorphins; Humans; Nerve Tissue Proteins; Neurotensin; Oligopeptides; Pain; Somatostatin; Substance P; Thyrotropin-Releasing Hormone; Vasoactive Intestinal Peptide; Vasopressins | 1982 |
Capsaicin--a literature survey.
Topics: Analgesia; Animals; Blood Pressure; Body Temperature Regulation; Capsaicin; Cardiovascular System; Chemical Phenomena; Chemistry; Colon; Dose-Response Relationship, Drug; Drug Tolerance; Fatty Acids, Unsaturated; Heart Rate; Histamine; Intestine, Small; Liver; Muscle, Smooth, Vascular; Myocardial Contraction; Pain; Phagocytosis; Respiratory System; Stomach Ulcer; Substance P; Vagus Nerve | 1982 |
[Substance P - a neuropeptide transmitter].
Topics: Animals; Body Temperature Regulation; Digestive System; Drug Interactions; Guinea Pigs; Hemodynamics; Humans; Locomotion; Neurons; Neurotransmitter Agents; Pain; Pancreatic Juice; Rabbits; Rats; Salivation; Sleep; Substance P; Tissue Distribution | 1982 |
Capsaicin and sensory neurones--a review.
Topics: Animals; Axonal Transport; Axons; Capsaicin; Cholecystokinin; Edema; Fatty Acids, Unsaturated; Ganglia, Spinal; Nerve Degeneration; Nerve Fibers; Neurons, Afferent; Pain; Rats; Reflex; Sensation; Substance P | 1983 |
Implications of neuropeptides in neurological diseases.
Topics: Alzheimer Disease; Animals; Brain; Cholecystokinin; Choline O-Acetyltransferase; Endorphins; Epilepsy; Forecasting; Histocytochemistry; Humans; Huntington Disease; Migraine Disorders; Nerve Tissue Proteins; Nervous System Diseases; Pain; Parkinson Disease; Radioimmunoassay; Somatostatin; Substance P; Thyrotropin-Releasing Hormone; Tissue Distribution; Vasopressins | 1984 |
[Substance P].
Topics: Animals; Autonomic Nervous System; Brain Chemistry; Humans; Memory; Motor Activity; Neurons; Pain; Peripheral Nerves; Spinal Cord; Substance P; Substantia Nigra; Synapses | 1984 |
Pain--mechanics and management.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents; Antidepressive Agents, Tricyclic; Arachidonic Acids; Autonomic Nervous System; Chronic Disease; Humans; Neurons, Afferent; Nociceptors; Pain; Pain Management; Psychotropic Drugs; Sensory Thresholds; Substance P; Sympatholytics; Transcutaneous Electric Nerve Stimulation | 1984 |
Neonatal pain.
Topics: Crying; Facial Expression; Humans; Infant, Newborn; Pain; Pain Measurement; Substance P | 1993 |
Innervation of the synovium.
Topics: Arthritis, Rheumatoid; Endopeptidases; Humans; Joints; Neurons, Afferent; Pain; Substance P; Synovial Membrane | 1995 |
Substance P and inflammatory pain: potential of substance P antagonists as analgesics.
Topics: Animals; Electrophysiology; Humans; Inflammation; Pain; Spinal Cord; Substance P; Synapses | 1993 |
Substance P receptor (NK-1) in the central nervous system: possible functions from a morphological aspect.
Topics: Acetylcholine; Animals; Brain; Neurokinin A; Pain; Receptors, Glutamate; Receptors, Neurokinin-1; Receptors, Neurokinin-2; RNA, Messenger; Substance P | 1993 |
Participation of substance P in spinal physiological responses to peripheral aversive stimulation.
Topics: Animals; Biphenyl Compounds; Hypnotics and Sedatives; Neurokinin A; Neurons; Pain; Receptors, Neurokinin-2; Reflex; Spinal Cord; Substance P | 1993 |
Organization of substance P primary sensory neurons: ultrastructural and physiological correlates.
Topics: Animals; Cats; Evoked Potentials; Microscopy, Electron; Nerve Endings; Neurons; Neurons, Afferent; Pain; Spinal Cord; Substance P | 1993 |
Discovery of CP-96,345 and its characterization in disease models involving substance P.
Topics: Analgesics; Animals; Asthma; Binding, Competitive; Biphenyl Compounds; Disease Models, Animal; Inflammation; Pain; Receptors, Neurokinin-2; Substance P | 1993 |
[Capsaicin for arthritic pain].
Topics: Analgesics; Animals; Arthritis; Arthritis, Experimental; Capsaicin; Humans; Pain; Substance P | 1996 |
Phenotypic modification of primary sensory neurons: the role of nerve growth factor in the production of persistent pain.
Topics: Animals; Ganglia, Spinal; Humans; Hyperalgesia; Inflammation; Models, Neurological; Nerve Growth Factors; Neurons, Afferent; Pain; Peripheral Nerves; Phenotype; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Substance P | 1996 |
Alterations in neurokinin 1 receptor gene expression in models of pain and inflammation.
Topics: Animals; Arthritis, Rheumatoid; Gene Expression Regulation; Humans; Pain; Receptors, Neurokinin-1; Substance P | 1995 |
Lumbar facet pain: biomechanics, neuroanatomy and neurophysiology.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Biomechanical Phenomena; Humans; Inflammation; Lumbar Vertebrae; Male; Muscles; Nerve Fibers, Myelinated; Nervous System; Pain; Phospholipases A; Physical Stimulation; Rabbits; Substance P; Weight-Bearing | 1996 |
The possible role of substance P in eliciting and modulating deep somatic pain.
Topics: Afferent Pathways; Animals; Muscle, Skeletal; Pain; Spinal Cord; Substance P | 1996 |
[Trichodynia].
Topics: Alopecia; Female; Humans; Neuropeptides; Pain; Scalp; Skin Diseases; Stress, Psychological; Substance P | 1997 |
Neuropeptides and steroid hormones in arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Female; Gonadal Steroid Hormones; Humans; Hypothalamo-Hypophyseal System; Male; Neuropeptides; Pain; Peripheral Nerves; Pituitary-Adrenal System; Pregnancy; Steroids; Substance P | 1998 |
Null mutations lacking substance: elucidating pain mechanisms by genetic pharmacology.
Topics: Animals; Brain Chemistry; Mice; Mice, Knockout; Mutagenesis; Pain; Spinal Cord; Substance P | 1998 |
[Biochemistry of pain].
Topics: Afferent Pathways; Animals; Capsaicin; Glutamic Acid; Humans; Narcotics; Nerve Growth Factors; Neurons, Afferent; Pain; Peripheral Nerves; Prostaglandins; Spinal Cord; Substance P | 1999 |
Central mechanisms in pain.
Topics: Central Nervous System; Glutamic Acid; Humans; Pain; Spinal Cord; Substance P | 1999 |
Distinct neurochemical features of acute and persistent pain.
Topics: Acute Disease; Animals; Chronic Disease; Humans; Isoenzymes; Mice; Mice, Knockout; Neurochemistry; Neurokinin A; Pain; Protein Kinase C; Protein Precursors; Substance P; Tachykinins | 1999 |
Wind-up of spinal cord neurones and pain sensation: much ado about something?
Topics: Afferent Pathways; Analgesics; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Humans; Hyperalgesia; Inflammation; Ion Transport; Models, Neurological; Morphine; Nerve Fibers; Nerve Tissue Proteins; Neuralgia; Neuronal Plasticity; Neurons, Afferent; Neuropeptides; Nociceptors; Pain; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Reflex; Spinal Cord; Substance P; Synaptic Transmission; Viscera | 2000 |
NK1 (substance P) receptor antagonists--why are they not analgesic in humans?
Topics: Analgesia; Animals; Drug Evaluation, Preclinical; Humans; Mice; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Pain; Receptors, Neurokinin-1; Species Specificity; Substance P | 2000 |
Is fibromyalgia a distinct clinical syndrome?
Topics: Autonomic Nervous System; Chronic Disease; Demography; Fibromyalgia; Humans; Neurologic Examination; Neurosecretory Systems; Nociceptors; Pain; Pain Threshold; Spinal Cord; Substance P | 2000 |
Substance P.
Topics: Central Nervous System; Humans; Pain; Substance P | 2000 |
Activity-dependent changes in the pain matrix.
Topics: Animals; Arthritis, Experimental; Autoradiography; Carbon Radioisotopes; Deoxyglucose; Electrophysiology; Glutamic Acid; Motor Activity; Neurons; Pain; Rats; Receptors, Glutamate; Spinal Cord; Substance P; Synaptic Transmission | 2000 |
Neurochemical plasticity in persistent inflammatory pain.
Topics: Animals; Humans; Inflammation; Neuronal Plasticity; Pain; Posterior Horn Cells; Receptors, Neurokinin-1; Substance P | 2000 |
Substance P: transmitter of nociception (Minireview).
Topics: Animals; Enkephalins; Excitatory Postsynaptic Potentials; Humans; Nerve Endings; Neuropeptides; Pain; Receptors, Tachykinin; Spinal Cord; Substance P; Synaptic Transmission | 2000 |
Substance P: a new era, a new role.
Topics: Animals; Antidepressive Agents, Second-Generation; Aprepitant; Depression; Humans; Morpholines; Neuropeptides; Pain; Stress, Psychological; Substance P; Synaptic Transmission | 2001 |
Role of neurotransmitters in sensitization of pain responses.
Topics: Animals; Biphenyl Compounds; Capsaicin; Excitatory Amino Acid Agonists; Haplorhini; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Long-Term Potentiation; Mechanoreceptors; Microdialysis; Models, Animal; Models, Neurological; Neurons, Afferent; Neurotransmitter Agents; Nociceptors; Pain; Phosphorylation; Posterior Horn Cells; Protein Processing, Post-Translational; Rats; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Signal Transduction; Spinothalamic Tracts; Substance P | 2001 |
[Why are substance P(NK1)-receptor antagonists ineffective in pain treatment?].
Topics: Analgesics; Animals; Humans; Neurokinin-1 Receptor Antagonists; Pain; Substance P | 2002 |
Neurochemistry and behavior in man.
Topics: Affective Symptoms; Behavior; Biogenic Amines; Brain Chemistry; Cyclic AMP; Cyclic GMP; Deficiency Diseases; Humans; Neurochemistry; Neurons; Neurotransmitter Agents; Pain; Peptides; Prostaglandins; Proteins; Receptors, Drug; Schizophrenia; Substance P; Substance-Related Disorders; Synaptic Transmission | 1976 |
Neuropeptides and pain: neurosurgical implications.
Topics: Amino Acid Sequence; Angiotensin II; Animals; Brain Chemistry; Chemical Phenomena; Chemistry; Endorphins; Enkephalins; Mesencephalon; Neurotensin; Nociceptors; Pain; Peptides; Raphe Nuclei; Rats; Serotonin; Somatostatin; Spinal Cord; Substance P; Trigeminal Caudal Nucleus | 1979 |
Roles of peptides in central transmission: substance P, bradykinin and B-endorphin.
Topics: Animals; Anura; beta-Endorphin; Bradykinin; Cats; Central Nervous System; Endorphins; Pain; Peptides; Rats; Spinal Cord; Substance P; Synaptic Transmission; Trigeminal Nuclei | 1979 |
Central pain mechanisms.
Topics: Afferent Pathways; Animals; Brain; Brain Mapping; Cats; Electric Stimulation; Endorphins; Enkephalins; Humans; Mice; Naloxone; Neural Inhibition; Nociceptors; Pain; Pain, Intractable; Rats; Spinal Cord; Spinothalamic Tracts; Substance P; Substantia Gelatinosa | 1978 |
[Neurotransmitters and the pain transmission system].
Topics: Calcitonin Gene-Related Peptide; Humans; Neurotransmitter Agents; Pain; Substance P; Synaptic Transmission | 1992 |
[Physiological chemistry and pharmacology of pain].
Topics: Analgesics; Animals; Brain Stem; Electric Stimulation; Endorphins; Humans; Narcotics; Neuropeptides; Nociceptors; Pain; Spinal Cord; Substance P | 1990 |
Pain and neurotransmitters.
Topics: Action Potentials; Afferent Pathways; Analgesics; Animals; Animals, Newborn; Enkephalins; GABA Antagonists; gamma-Aminobutyric Acid; Mice; Neurotransmitter Agents; Nociceptors; Pain; Rats; Spinal Cord; Substance P | 1990 |
Neuropeptides and pain.
Topics: Animals; Calcitonin; Calcitonin Gene-Related Peptide; Corticotropin-Releasing Hormone; Endorphins; Humans; Neuropeptides; Neurotensin; Nociceptors; Pain; Rats; Somatostatin; Substance P | 1990 |
Unraveling the mystery of pain.
Topics: Arachidonic Acid; Arachidonic Acids; Attitude of Health Personnel; Attitude to Health; Humans; Nociceptors; Pain; Phospholipids; Prostaglandins; Spinothalamic Tracts; Substance P | 1991 |
The tachykinin neuroimmune connection in inflammatory pain.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Genes, fos; Humans; Inflammation; Models, Neurological; Nervous System; Nervous System Physiological Phenomena; Neurons, Afferent; Neuropeptides; Pain; Rats; Substance P; Tachykinins | 1991 |
Symptomatologic interdependence or interindependence as a key alternative in migraine and cluster headache mechanisms.
Topics: Cluster Headache; Humans; Migraine Disorders; Nociceptors; Pain; Substance P; Vascular Headaches | 1985 |
Postsympathectomy pain and changes in sensory neuropeptides: towards an animal model.
Topics: Animals; Calcitonin Gene-Related Peptide; Iris; Lumbosacral Region; Nerve Fibers; Nerve Growth Factors; Nerve Tissue Proteins; Pain; Parotid Gland; Substance P; Sympathectomy; Syndrome; Time Factors; Trigeminal Nerve | 1985 |
A pharmacological overview of opioid mechanisms mediating analgesia and hyperalgesia.
Topics: Adrenergic Fibers; Afferent Pathways; Analgesics; Animals; Central Nervous System; Cholinergic Fibers; Endorphins; Enkephalins; Feedback; Female; Humans; Interneurons; Macaca mulatta; Male; Mice; Models, Neurological; Neural Conduction; Neural Inhibition; Pain; Receptors, Opioid; Spinothalamic Tracts; Substance P; Substantia Gelatinosa; Synaptic Transmission; Tabes Dorsalis; Thalamus | 1985 |
Neuropeptide effects on brain development.
Topics: 5,7-Dihydroxytryptamine; Adrenocorticotropic Hormone; Animals; Animals, Newborn; Behavior, Animal; Brain; Hydroxydopamines; Learning; Melanocyte-Stimulating Hormones; Methadone; Mitosis; Narcotics; Neural Pathways; Neurotransmitter Agents; Organ Size; Oxidopamine; Pain; Peptides; Psychomotor Performance; Rats; Sensory Thresholds; Somatostatin; Substance P; Thyrotropin-Releasing Hormone; Vasoactive Intestinal Peptide | 1985 |
[Pharmacological effects of neurotensin, substance P and tuftsin].
Topics: Animals; Central Nervous System; Digestive System; Hemodynamics; Humans; Neurotensin; Pain; Phagocytosis; Receptors, Dopamine; Substance P; Synaptic Transmission; Tuftsin | 1985 |
Neuropeptides and their role in nociception and analgesia.
Topics: Animals; Bombesin; Bradykinin; Calcitonin; Central Nervous System; Cholecystokinin; Endorphins; Neurons, Afferent; Neuropeptides; Neurotensin; Pain; Somatostatin; Substance P; Vasopressins | 1986 |
Analgesia and neuropeptides.
Topics: Analgesia; Animals; Cholecystokinin; Endorphins; Humans; Neuropeptides; Neurotensin; Pain; Substance P | 1988 |
[The role of biologically active substances in the control of pain syndrome (review of the literature)].
Topics: Animals; beta-Endorphin; Brain; Endorphins; Enkephalins; Humans; Pain; Rats; Receptors, Opioid; Spinal Cord; Substance P | 1989 |
[The role of neuropeptides in neural somatic reflexes].
Topics: Animals; Cats; Dental Pulp; Electric Stimulation; Humans; Hypoglossal Nerve; Jaw; Models, Neurological; Pain; Rats; Reflex; Substance P; Trigeminal Nerve | 1989 |
[Mechanics of actions of analgesics--especially on peripheral actions].
Topics: Acetylcholine; Analgesics; Animals; Bradykinin; Catecholamines; Chemoreceptor Cells; Drug Synergism; Histamine; Humans; Morphine; Pain; Peptide Hydrolases; Peripheral Nerves; Prostaglandins; Sensory Receptor Cells; Serotonin; Substance P | 1973 |
21 trial(s) available for substance p and Ache
| Article | Year |
|---|---|
[Behavioural and physiological indicators of pain and distress in calves following tail docking].
Topics: Animal Husbandry; Animals; Behavior, Animal; Cattle; Double-Blind Method; Hydrocortisone; Male; Pain; Pilot Projects; Stress, Physiological; Substance P; Tail | 2020 |
Effects of ibuprofen and low-level laser therapy on orthodontic pain by means of the analysis of interleukin 1-beta and substance P levels in the gingival crevicular fluid.
Topics: Gingival Crevicular Fluid; Humans; Ibuprofen; Interleukin-1beta; Low-Level Light Therapy; Pain; Pain Management; Substance P | 2021 |
The effect of intra-articular botulinum toxin A on substance P, prostaglandin E
Topics: Animals; Arthralgia; Botulinum Toxins, Type A; Dinoprostone; Dog Diseases; Dogs; Double-Blind Method; Female; Injections, Intra-Articular; Male; Osteoarthritis; Pain; Pain Management; Substance P; Synovial Fluid; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Decline of substance P levels after stress management with cognitive behaviour therapy in women with the fibromyalgia syndrome.
Topics: Cognitive Behavioral Therapy; Female; Fibromyalgia; Humans; Middle Aged; Pain; Psychometrics; Substance P; Surveys and Questionnaires | 2019 |
Effect of castration method on neurohormonal and electroencephalographic stress indicators in Holstein calves of different ages.
Topics: Aging; Analgesics; Animal Welfare; Animals; Cattle; Cattle Diseases; Electroencephalography; Heart Rate; Hydrocortisone; Male; Orchiectomy; Pain; Pain Measurement; Stress, Physiological; Substance P | 2013 |
Expression of substance P, calcitonin gene-related peptide, β-endorphin and methionine-enkephalin in human dental pulp tissue after orthodontic intrusion: a pilot study.
Topics: Adolescent; beta-Endorphin; Bicuspid; Calcitonin Gene-Related Peptide; Child; Dental Pulp; Enkephalin, Methionine; Female; Humans; Male; Neurogenic Inflammation; Neurotransmitter Agents; Opioid Peptides; Pain; Pilot Projects; Substance P; Tooth Movement Techniques | 2014 |
Effect of 1440-nanometer neodymium:yttrium-aluminum-garnet laser irradiation on pain and neuropeptide reduction: a randomized prospective clinical trial.
Topics: Adult; Calcitonin Gene-Related Peptide; Cytokines; Dental Pulp Cavity; Exudates and Transudates; Female; Follow-Up Studies; Humans; Inflammation Mediators; Lasers, Solid-State; Low-Level Light Therapy; Male; Matrix Metalloproteinase 8; Middle Aged; Neuropeptides; Neurotransmitter Agents; Optical Fibers; Pain; Pain Measurement; Percussion; Periapical Periodontitis; Prospective Studies; Retreatment; Substance P; Vasodilator Agents | 2014 |
The effects of firocoxib on cautery disbudding pain and stress responses in preweaned dairy calves.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Cautery; Female; Horns; Hydrocortisone; Male; Neurotransmitter Agents; Pain; Substance P; Sulfones | 2015 |
Phototoxic reactions in healthy volunteers following photodynamic therapy with methylaminolevulinate cream or with cream containing 5-aminolevulinic acid: a phase II, randomized study.
Topics: Administration, Topical; Aminolevulinic Acid; Area Under Curve; Humans; Pain; Photochemotherapy; Photosensitizing Agents; Reference Values; Substance P | 2009 |
Intra-articular opioid analgesia is effective in reducing pain and inflammation in an equine LPS induced synovitis model.
Topics: Analgesics, Opioid; Animals; Bradykinin; Cross-Over Studies; Dinoprostone; Female; Horse Diseases; Horses; Inflammation; Injections, Intra-Articular; Lipopolysaccharides; Morphine; Pain; Proteins; Substance P; Synovial Fluid; Synovitis | 2010 |
Substance P-induced skin inflammation is not modulated by a single dose of sitagliptin in human volunteers.
Topics: Capsaicin; Carbonated Beverages; Cross-Over Studies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Eruptions; Edema; Erythema; Humans; Injections, Intradermal; Male; Pain; Pyrazines; Sitagliptin Phosphate; Skin; Substance P; Triazoles; Vasodilation | 2011 |
Pharmacokinetics and effect of intravenous meloxicam in weaned Holstein calves following scoop dehorning without local anesthesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Cattle Diseases; Heart Rate; Horns; Hydrocortisone; Meloxicam; Pain; Substance P; Thiazines; Thiazoles; Weight Gain | 2012 |
Release of algesic substances in human experimental muscle pain.
Topics: Adult; Arm; Dinoprostone; Exercise; Female; Glutamic Acid; Humans; Hypertonic Solutions; Inflammation; Lactic Acid; Leg; Male; Microdialysis; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal; Nitric Oxide; Pain; Pain Measurement; Sodium Chloride; Substance P; Time Factors | 2002 |
Effects of tramadol on synovial fluid concentrations of substance P and interleukin-6 in patients with knee osteoarthritis: comparison with paracetamol.
Topics: Acetaminophen; Administration, Oral; Aged; Double-Blind Method; Female; Humans; Interleukin-6; Male; Middle Aged; Osteoarthritis, Knee; Pain; Pain Measurement; Prospective Studies; Substance P; Synovial Fluid; Time Factors; Tramadol | 2003 |
The effect of short-term epidural local anesthetic blockade on urinary levels of substance P in interstitial cystitis.
Topics: Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Cystitis, Interstitial; Humans; Pain; Pain Measurement; Radioimmunoassay; Substance P | 2004 |
Quality of life and pain in premenopausal women with major depressive disorder: the POWER Study.
Topics: Adult; Alendronate; Bone Density; Bone Density Conservation Agents; Calcitonin Gene-Related Peptide; Case-Control Studies; Depressive Disorder, Major; Female; Humans; Longitudinal Studies; Middle Aged; Pain; Pain Measurement; Premenopause; Quality of Life; Stress, Psychological; Substance P | 2006 |
Substance P potentiates the algogenic effects of intraarterial infusion of adenosine.
Topics: Adenosine; Adult; Aged; Chest Pain; Coronary Vessels; Drug Synergism; Female; Humans; Iliac Artery; Infusions, Intra-Arterial; Male; Middle Aged; Pain; Pain Threshold; Substance P | 1994 |
[Evaluation of the efficacy of intra-articular administration of somatostatin in rheumatoid arthritis].
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Child; Child, Preschool; Drug Evaluation; Evaluation Studies as Topic; Female; Humans; Injections, Intra-Articular; Male; Middle Aged; Pain; Somatostatin; Substance P; Thermography | 1993 |
Plasma and saliva substance P levels: the effects of acute pain in pregnant and non-pregnant women.
Topics: Acute Disease; Adult; Analysis of Variance; Demography; Female; Humans; Middle Aged; Pain; Pain Measurement; Pregnancy; Pregnancy Complications; Saliva; Substance P | 1997 |
Objective evaluation of pain in various spinal diseases: neuropeptide immunoreactivity in the cerebrospinal fluid.
Topics: Activities of Daily Living; beta-Endorphin; Humans; Low Back Pain; Neuropeptides; Pain; Pain Measurement; Radioimmunoassay; Spinal Cord Diseases; Substance P | 1997 |
Reactions to intradermally injected substance P and topically applied mustard oil in atopic dermatitis patients.
Topics: Acute Disease; Administration, Topical; Adolescent; Adult; Dermatitis, Atopic; Dose-Response Relationship, Drug; Drug Eruptions; Female; Humans; Injections, Intradermal; Male; Middle Aged; Mustard Plant; Pain; Plant Extracts; Plant Oils; Single-Blind Method; Substance P | 1991 |
656 other study(ies) available for substance p and Ache
| Article | Year |
|---|---|
Analgesic effects of a 5-HT3 receptor antagonist in an animal model of complex regional pain syndrome.
Topics: Analgesics; Animals; Benzimidazoles; Brain Stem; Complex Regional Pain Syndromes; Cytokines; Disease Models, Animal; Pain; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Antagonists; Substance P; Tibial Fractures | 2021 |
Pinocembrin relieves hip fracture-induced pain by repressing spinal substance P signaling in aged rats.
Topics: Aging; Animals; Disease Models, Animal; Flavanones; Hip Fractures; Indoles; Male; Neurokinin-1 Receptor Antagonists; Nociceptive Pain; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Signal Transduction; Substance P | 2022 |
Are the nerves supplying the anterior sacroiliac joint nociceptive?
Topics: Adult; Cadaver; Humans; Nerve Tissue; Nociception; Pain; Sacroiliac Joint; Substance P | 2023 |
Participation of transient receptor potential vanilloid 1 in the analgesic effect of duloxetine for paclitaxel induced peripheral neuropathic pain.
Topics: Analgesics; Animals; Antineoplastic Agents; Calcitonin Gene-Related Peptide; Duloxetine Hydrochloride; Ganglia, Spinal; Hyperalgesia; Neuralgia; Paclitaxel; Pain; Peripheral Nervous System Diseases; Rats; Spinal Cord Dorsal Horn; Substance P; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2022 |
Estrogenic impregnation alters pain expression: analysis through functional neuropeptidomics in a surgical rat model of osteoarthritis.
Topics: Animals; Calcitonin Gene-Related Peptide; Estradiol; Female; Osteoarthritis; Pain; Prospective Studies; Rats; Rats, Sprague-Dawley; Substance P | 2022 |
Characterizing the diagnostic sensitivity and specificity of pain biomarkers in cattle using receiver operating characteristic curves.
Topics: Analgesics; Animals; Biomarkers; Cattle; Hydrocortisone; Pain; ROC Curve; Sensitivity and Specificity; Substance P | 2022 |
[Visual acupotomy intervention mitigates pain reaction by improving intervertebral disc degeneration and inhibiting apoptosis of nucleus pulposus cells in rabbits with cervical spondylosis].
Topics: Acupuncture Therapy; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Dinoprostone; Intervertebral Disc Degeneration; Male; Meloxicam; Nucleus Pulposus; Pain; Proto-Oncogene Proteins c-bcl-2; Rabbits; Serotonin; Spondylosis; Substance P | 2022 |
The Role of Substance P, Neurokinin A, Neuropeptide Y, and Cortisol in Assessing Neonatal Pain.
Topics: Humans; Hydrocortisone; Infant; Infant, Newborn; Neurokinin A; Neuropeptide Y; Pain; Prospective Studies; Substance P | 2023 |
Endogenous Inflammatory Mediators Produced by Injury Activate TRPV1 and TRPA1 Nociceptors to Induce Sexually Dimorphic Cold Pain That Is Dependent on TRPM8 and GFRα3.
Topics: Animals; Calcitonin Gene-Related Peptide; Cold Temperature; Female; Glial Cell Line-Derived Neurotrophic Factor; Hyperalgesia; Male; Mice; Neurogenic Inflammation; Nociceptors; Pain; Sensory Receptor Cells; Substance P; Toll-Like Receptor 4; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels | 2023 |
Self-ligating brackets do not reduce discomfort or pain when compared to conventional orthodontic appliances in Class I patients: a clinical study.
Topics: Dental Alloys; Humans; Orthodontic Appliance Design; Orthodontic Appliances; Orthodontic Brackets; Orthodontic Wires; Pain; Substance P | 2023 |
Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief.
Topics: Animals; Aprepitant; Endosomes; Humans; Mice; Pain; Receptors, G-Protein-Coupled; Receptors, Neurokinin-1; Substance P | 2023 |
Evaluation of Substance P concentrations in the blood plasma of jugular and tail vein of healthy German Simmental cows.
Topics: Animals; Cattle; Female; Pain; Pilot Projects; Plasma; Substance P; Tail | 2023 |
Calcium imaging of primary canine sensory neurons: Small-diameter neurons responsive to pruritogens and algogens.
Topics: Animals; Cadaver; Calcium Radioisotopes; Capsaicin; Cattle; Cells, Cultured; Chloroquine; Dogs; Ganglia, Spinal; Histamine; Humans; Laminectomy; Molecular Imaging; Neurotransmitter Agents; Pain; Peptide Fragments; Pruritus; Radiopharmaceuticals; Sensory Receptor Cells; Serotonin; Serotonin Receptor Agonists; Substance P | 2019 |
Daytime changes of salivary biomarkers involved in pain.
Topics: Biomarkers; Glutamic Acid; Humans; Pain; Saliva; Substance P; Young Adult | 2020 |
CCL17 in Inflammation and Pain.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Chemokine CCL17; Genes, Reporter; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Mice; Mice, Transgenic; Nerve Growth Factor; Pain; Pain Measurement; Peritonitis; Pneumonia; Signal Transduction; Substance P | 2020 |
Pain May Promote Tumor Progression via Substance P-Dependent Modulation of Toll-like Receptor-4.
Topics: Humans; Neoplasms; Pain; Receptors, Neurokinin-1; Substance P; Toll-Like Receptor 4 | 2020 |
Continuous infusion of substance P inhibits acute, but not subacute, inflammatory pain induced by complete Freund's adjuvant.
Topics: Acute Disease; Analgesics; Animals; Corpus Striatum; Edema; Freund's Adjuvant; Hyperalgesia; Inflammation; Infusions, Parenteral; Male; Pain; Pain Threshold; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P | 2020 |
Electroacupuncture alleviates inflammatory pain via adenosine suppression and its mediated substance P expression.
Topics: Adenosine; Animals; Electroacupuncture; Pain; Rats; Rats, Sprague-Dawley; Substance P | 2020 |
UVB irradiation induces contralateral changes in galanin, substance P and c-fos immunoreactivity in rat dorsal root ganglia, dorsal horn and lateral spinal nucleus.
Topics: Animals; Galanin; Ganglia, Spinal; Humans; Medulla Oblongata; Neurons; Neuropeptides; Pain; Proto-Oncogene Proteins c-fos; Rats; Sciatic Nerve; Spinal Cord; Spinal Cord Dorsal Horn; Substance P; Ultraviolet Rays | 2021 |
Bee venom reduces burn-induced pain via the suppression of peripheral and central substance P expression in mice.
Topics: Bee Venoms; Burns; Central Nervous System; Dose-Response Relationship, Drug; Pain; Pain Management; Peripheral Nervous System; Substance P | 2021 |
Chaiqin chengqi decoction ameliorates acute pancreatitis in mice via inhibition of neuron activation-mediated acinar cell SP/NK1R signaling pathways.
Topics: Acinar Cells; Analgesics; Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Ceruletide; Drugs, Chinese Herbal; Emodin; Flavonoids; Ganglia, Spinal; Humans; Lignans; Male; Mice, Inbred C57BL; Neurons; Pain; Pancreas; Pancreatitis; Receptors, Neurokinin-1; Signal Transduction; Spinal Cord; Substance P | 2021 |
Enhanced Neurokinin-1 Receptor Expression Is Associated with Human Dental Pulp Inflammation and Pain Severity.
Topics: Adolescent; Adult; Case-Control Studies; Dental Pulp; Female; Humans; Inflammation; Male; Pain; Pain Measurement; Receptors, Neurokinin-1; Substance P; Young Adult | 2021 |
Sex-related differences in response to masseteric injections of glutamate and nerve growth factor in healthy human participants.
Topics: Adult; Biomarkers; Connective Tissue; Female; Glutamic Acid; Healthy Volunteers; Humans; Injections; Male; Masseter Muscle; Mastication; Muscle Cells; Nerve Fibers; Nerve Growth Factor; Pain; Pain Threshold; Pressure; Receptors, N-Methyl-D-Aspartate; Sex Characteristics; Substance P; Time Factors | 2021 |
Mechanisms of nerve growth factor signaling in bone nociceptors and in an animal model of inflammatory bone pain.
Topics: Action Potentials; Animals; Antibodies; Bone and Bones; Calcitonin Gene-Related Peptide; Disease Models, Animal; Freund's Adjuvant; Male; NAV1.8 Voltage-Gated Sodium Channel; NAV1.9 Voltage-Gated Sodium Channel; Nerve Growth Factor; Nociceptors; Osteoarthritis; Pain; Rats; Rats, Sprague-Dawley; Signal Transduction; Substance P; TRPV Cation Channels; Ubiquitin Thiolesterase | 2017 |
[Role of substance P and calcitonin gene-related peptide in bone metabolism].
Topics: Bone and Bones; Calcitonin Gene-Related Peptide; Fracture Healing; Humans; Pain; Substance P | 2017 |
Age Differences in the Time Course and Magnitude of Changes in Circulating Neuropeptides After Pain Evocation in Humans.
Topics: Aged; Aging; Analysis of Variance; beta-Endorphin; Biomarkers; Cold Temperature; Female; Hot Temperature; Humans; Male; Pain; Pressure; Substance P; Time Factors; Young Adult | 2017 |
Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR1) gene.
Topics: Animals; Arthralgia; Cohort Studies; Female; Genetic Variation; Genotype; Humans; Osteoarthritis, Knee; Pain; Phenotype; Polymorphism, Single Nucleotide; Receptors, Neurokinin-1; Substance P | 2017 |
Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief.
Topics: Animals; beta-Arrestins; Cell Compartmentation; Clathrin; Dynamins; Endocytosis; Endosomes; GTP-Binding Proteins; HEK293 Cells; Humans; Lipids; Models, Biological; Molecular Targeted Therapy; Neurokinin-1 Receptor Antagonists; Neurons; Nociception; Pain; Protein Binding; Rats; Receptors, Neurokinin-1; Signal Transduction; Spinal Cord; Subcellular Fractions; Substance P | 2017 |
[Expressions of SP and NK-1R increase in the posterior horn of the L5－S2 spinal cord in rats with chronic nonbacterial prostatitis].
Topics: Animals; Interleukin-10; Interleukin-1beta; Interleukin-2; Male; Pain; Prostatitis; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P; Tumor Necrosis Factor-alpha | 2016 |
Substance P in Dorsal Root Ganglion Neurons in Young and Adult Rats, after Nociceptive Stimulation during the Neonatal Period.
Topics: Animals; Female; Ganglia, Spinal; Immunohistochemistry; Male; Neurons; Nociception; Pain; Rats; Rats, Wistar; Substance P | 2018 |
A new tool to test active ingredient using lactic acid in vitro, a help to understand cellular mechanism involved in stinging test: An example using a bacterial polysaccharide (Fucogel
Topics: Acid Sensing Ion Channels; Adult; Aged; Animals; Carrier Proteins; Coculture Techniques; Female; Humans; Hydrogen-Ion Concentration; Keratinocytes; Lactic Acid; Middle Aged; Nerve Tissue Proteins; Pain; PC12 Cells; Polysaccharides, Bacterial; Rats; Skin; Substance P; TRPV Cation Channels; Young Adult | 2018 |
Effect of timing of subcutaneous meloxicam administration on indicators of pain after knife castration of weaned calves.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Canada; Cattle; Female; Haptoglobins; Hydrocortisone; Inflammation; Injections; Male; Meloxicam; Orchiectomy; Pain; Random Allocation; Substance P; Thiazines; Thiazoles; Weaning | 2017 |
Antinociceptive profiles and mechanisms of centrally administered oxyntomodulin in various mouse pain models.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Cytokines; Disease Models, Animal; Formaldehyde; Glutamic Acid; Injections, Intraventricular; Injections, Spinal; Male; Mice, Inbred ICR; Nociception; Oxyntomodulin; Pain; Rotarod Performance Test; Spinal Cord; Substance P | 2018 |
Saliva as a medium to detect and measure biomarkers related to pain.
Topics: Adult; Biomarkers; Blotting, Western; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Related Peptide; Female; Gene Expression; Glutamic Acid; Healthy Volunteers; Humans; Luminescence; Male; Nerve Growth Factor; Pain; Plasma; Saliva; Specimen Handling; Substance P; Young Adult | 2018 |
Transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 contribute to the progression of colonic inflammation in dextran sulfate sodium-induced colitis in mice: Links to calcitonin gene-related peptide and substance P.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Colitis; Dextran Sulfate; Disease Models, Animal; Disease Progression; Male; Mice, Inbred C57BL; Nerve Fibers; Pain; Substance P; TRPA1 Cation Channel; TRPV Cation Channels; Up-Regulation | 2018 |
Antagonism of Transient Receptor Potential Ankyrin Type-1 Channels as a Potential Target for the Treatment of Trigeminal Neuropathic Pain: Study in an Animal Model.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Hyperalgesia; Immunohistochemistry; Male; Pain; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Substance P; Trigeminal Nerve Diseases; TRPA1 Cation Channel; TRPV Cation Channels | 2018 |
Hemokinin-1 is an important mediator of pain in mouse models of neuropathic and inflammatory mechanisms.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nociception; Pain; Protein Precursors; Receptors, Neurokinin-1; Sciatic Nerve; Spinal Cord Dorsal Horn; Substance P; Tachykinins | 2019 |
NF-κB-Associated Pain-Related Neuropeptide Expression in Patients with Degenerative Disc Disease.
Topics: Adult; Female; Gene Expression Regulation; Humans; Intervertebral Disc; Intervertebral Disc Degeneration; Male; Middle Aged; NF-kappa B; NF-kappa B p50 Subunit; Pain; Signal Transduction; Substance P; Transcription Factor RelA; TRPV Cation Channels | 2019 |
Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously.
Topics: Humans; Mast Cells; Nerve Tissue Proteins; Neurogenic Inflammation; Pain; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Substance P | 2019 |
Effects of an Extract of Salmon Milt on Symptoms and Serum TNF and Substance P in Patients With Fibromyalgia Syndrome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Dietary Supplements; Fatigue; Female; Fibromyalgia; Humans; Male; Middle Aged; Pain; Salmon; Semen; Substance P; Tumor Necrosis Factor-alpha; Young Adult | 2019 |
Immunohistochemical demonstration of cyclooxygenase-2 in glomus tumors.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Cyclooxygenase 2; Female; Glomus Tumor; Hand; Humans; Male; Middle Aged; Pain; S100 Proteins; Soft Tissue Neoplasms; Substance P | 2013 |
Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch.
Topics: Animals; Cell Death; Cognition Disorders; Disease Models, Animal; Glutamate Decarboxylase; Green Fluorescent Proteins; Hyperalgesia; Interneurons; Lectins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oncogene Proteins v-fos; Pain; Pain Threshold; Phosphopyruvate Hydratase; Pruritus; Reaction Time; Receptors, Steroid; Receptors, Thyroid Hormone; Spinal Nerve Roots; Substance P | 2013 |
Neurokinin-1 receptor-expressing neurons that contain serotonin and gamma-aminobutyric acid in the rat rostroventromedial medulla are involved in pain processing.
Topics: Animals; Biotin; Cell Count; Dextrans; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Green Fluorescent Proteins; Medulla Oblongata; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Pathways; Neurons; Pain; Rats; Receptors, Neurokinin-1; Serotonin; Stilbamidines; Substance P | 2013 |
Antinociceptive profiles and mechanisms of orally administered coumarin in mice.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Coumarins; Formaldehyde; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Pain; Receptors, Opioid; Substance P | 2013 |
Mast cell activation contributes to sickle cell pathobiology and pain in mice.
Topics: Anemia, Sickle Cell; Animals; Benzamides; Cells, Cultured; Cytokines; Ganglia, Spinal; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hyperalgesia; Hypoxia; Imatinib Mesylate; Leukocyte Count; Mast Cells; Mice; Mice, Knockout; Mice, Transgenic; Microscopy, Confocal; Neurogenic Inflammation; Nociceptors; Pain; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Skin; Substance P | 2013 |
Reduced expression of pain mediators and pain sensitivity in amyloid precursor protein over-expressing CRND8 transgenic mice.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Blotting, Western; Calcitonin Gene-Related Peptide; Freund's Adjuvant; Hot Temperature; Humans; Immunohistochemistry; Inflammation; Male; Mice; Mice, Transgenic; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Recovery of Function; Substance P; TRPV Cation Channels | 2013 |
Mechanism underlying anti-hyperalgesic and anti-allodynic properties of anomalin in both acute and chronic inflammatory pain models in mice through inhibition of NF-κB, MAPKs and CREB signaling cascades.
Topics: Acute Disease; Adenosine Triphosphate; Analgesics; Animals; Chronic Disease; Coumarins; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hyperalgesia; Inflammation; Liver; Male; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase Type II; Nitrites; Pain; Signal Transduction; Substance P; Time Factors; Tumor Necrosis Factor-alpha | 2013 |
Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release.
Topics: Animals; Benzamides; Disease Models, Animal; Injections, Spinal; Ligands; Male; Pain; Pain Threshold; Piperazines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid, delta; Substance P | 2013 |
Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model.
Topics: Animals; Berberine; Caspase 3; Cerebral Cortex; Depression; Disease Models, Animal; Dopamine; Hippocampus; Hyperalgesia; Interleukin-1beta; Male; NF-kappa B; Nitrites; Nociception; Norepinephrine; Oxidative Stress; Pain; Rats, Wistar; Reserpine; Serotonin; Signal Transduction; Substance P; Superoxide Dismutase | 2013 |
A rat model of full thickness thermal injury characterized by thermal hyperalgesia, mechanical allodynia, pronociceptive peptide release and tramadol analgesia.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Burns; Calcitonin Gene-Related Peptide; Disease Models, Animal; Hyperalgesia; Male; Morphine; Nociception; Nociceptive Pain; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Tramadol | 2014 |
Botulinum toxin B in the sensory afferent: transmitter release, spinal activation, and pain behavior.
Topics: Afferent Pathways; Animals; Anti-Dyskinesia Agents; Botulinum Toxins; Botulinum Toxins, Type A; Capsaicin; Functional Laterality; Gene Expression Regulation; Hindlimb Suspension; Male; Mice; Mice, Inbred C57BL; Muscle Strength; Nociceptors; Pain; Pain Threshold; Posterior Horn Cells; Receptors, Neurokinin-1; Spinal Cord; Substance P; Time Factors | 2014 |
Involvement of substance p/neurokinin-1 receptor in the analgesic and anticancer activities of minimally toxic fraction from the traditional Chinese medicine Liu-Shen-Wan in vitro.
Topics: Analgesics; Antineoplastic Agents; Apoptosis; Bradykinin; Complex Mixtures; Dose-Response Relationship, Drug; Down-Regulation; Ganglia, Spinal; Hep G2 Cells; Hepatoblastoma; Humans; Liver Neoplasms; Medicine, Chinese Traditional; Mitochondria; Neoplasms; Pain; Phytotherapy; Receptors, Neurokinin-1; Substance P | 2014 |
Peripherally driven low-threshold inhibitory inputs to lamina I local-circuit and projection neurones: a new circuit for gating pain responses.
Topics: Animals; Electric Stimulation; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Neural Inhibition; Neural Pathways; Pain; Pain Perception; Periodicity; Rats, Wistar; Reaction Time; Signal Transduction; Spinal Cord Dorsal Horn; Substance P; Synaptic Transmission; Time Factors | 2014 |
Involvement of multiple µ-opioid receptor subtypes on the presynaptic or postsynaptic inhibition of spinal pain transmission.
Topics: Analgesics; Animals; Capsaicin; Male; Mice; N-Methylaspartate; Nociception; Oligopeptides; Pain; Presynaptic Terminals; Receptors, Opioid, mu; Somatostatin; Substance P; Synaptic Transmission | 2014 |
Increased substance P expression in the trochanteric bursa of patients with greater trochanteric pain syndrome.
Topics: Biopsy; Bursa, Synovial; Female; Femur; Humans; Pain; Prospective Studies; Retrospective Studies; Substance P; Tendons | 2014 |
μ-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; Neurons; Pain; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid, mu; Sciatic Nerve; Sciatica; Spinal Cord; Substance P | 2014 |
Proteasome inhibitor MG132 modulates inflammatory pain by central mechanisms in adjuvant arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Binding Sites; DNA; Female; Ganglia, Spinal; Leupeptins; Mycobacterium; NF-kappa B; Pain; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats, Inbred Lew; Spinal Cord; Substance P | 2017 |
Sustained neurochemical plasticity in central terminals of mouse DRG neurons following colitis.
Topics: Animals; Colitis; Dextran Sulfate; Ganglia, Spinal; Inflammation; Intestines; Lumbosacral Region; Male; Mice; Neuronal Plasticity; Pain; Posterior Horn Cells; Substance P | 2014 |
In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA.
Topics: Animals; Calcitonin Gene-Related Peptide; Endosomal Sorting Complexes Required for Transport; Ganglia, Spinal; Hot Temperature; Inflammation; Mice; Mice, Transgenic; Mutation; Nedd4 Ubiquitin Protein Ligases; Nerve Growth Factor; Neurons; Pain; Protein Binding; Receptor, trkA; Substance P; Ubiquitin-Protein Ligases; Ubiquitination | 2014 |
Immunohistochemical analysis of neuropeptides (protein gene product 9.5, substance P and calcitonin gene-related peptide) in hypertrophic burn scar with pain and itching.
Topics: Adult; Burns; Calcitonin Gene-Related Peptide; Case-Control Studies; Cicatrix, Hypertrophic; Female; Humans; Immunohistochemistry; Male; Middle Aged; Pain; Pruritus; Skin; Substance P; Ubiquitin Thiolesterase | 2014 |
Hemokinin-1 mediates pruriceptive processing in the rat spinal cord.
Topics: Animals; Disease Models, Animal; Formaldehyde; Histamine; Immunohistochemistry; Male; Nociception; Pain; Proto-Oncogene Proteins c-fos; Pruritus; Rats, Sprague-Dawley; Serotonin; Spinal Cord; Substance P; Tachykinins | 2014 |
Association between sensitisation and pain-related behaviours in an experimental canine model of osteoarthritis.
Topics: Analgesics; Animals; Behavior, Animal; Diphosphonates; Dogs; Osteoarthritis; Pain; Pain Measurement; Pain Threshold; Prealbumin; Spinal Cord; Substance P | 2014 |
Intra-articular (IA) ropivacaine microparticle suspensions reduce pain, inflammation, cytokine, and substance p levels significantly more than oral or IA celecoxib in a rat model of arthritis.
Topics: Administration, Oral; Amides; Animals; Arthritis, Experimental; Celecoxib; Cytokines; Inflammation; Injections, Intra-Articular; Male; Microspheres; Pain; Rats; Ropivacaine; Substance P | 2015 |
Healing of surgical castration wounds: a description and an evaluation of flunixin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Cattle; Clonixin; Injections; Lidocaine; Male; Orchiectomy; Pain; Scrotum; Substance P; Time Factors; Treatment Outcome; Weight Gain; Wound Healing | 2014 |
Neurochemical properties of BDNF-containing neurons projecting to rostral ventromedial medulla in the ventrolateral periaqueductal gray.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Related Peptide; Disease Models, Animal; Formaldehyde; Male; Medulla Oblongata; Microglia; Neural Pathways; Neurons; Neurotensin; Nitric Oxide Synthase; Pain; Parvalbumins; Periaqueductal Gray; Rats, Sprague-Dawley; Receptor, trkB; RNA, Messenger; Serotonin; Substance P; Tyrosine Decarboxylase | 2014 |
Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non-human primates.
Topics: Animals; Behavior, Animal; Catheterization; Cisterna Magna; Female; Injections, Spinal; Lumbosacral Region; Macaca mulatta; Male; Morphine; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pain; Pruritus; Receptors, Opioid; Substance P | 2015 |
[Roles of substance P and transient receptor potential vanilloid 1 in neuralgia in rats with chronic nonbacterial prostatitis].
Topics: Animals; Lumbosacral Region; Male; Neuralgia; Pain; Prostate; Prostatitis; Rats; Rats, Wistar; Spinal Cord; Substance P; TRPV Cation Channels | 2015 |
Protease-activated receptors in the Achilles tendon-a potential explanation for the excessive pain signalling in tendinopathy.
Topics: Achilles Tendon; Adult; Aged; Female; Humans; Immunohistochemistry; Male; Middle Aged; Pain; Receptors, Proteinase-Activated; Substance P; Tendinopathy | 2015 |
Facilitated spinal neuropeptide signaling and upregulated inflammatory mediator expression contribute to postfracture nociceptive sensitization.
Topics: Animals; Body Temperature; Calcitonin Gene-Related Peptide; Disease Models, Animal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Neuropeptides; Pain; Pain Measurement; Peptide Fragments; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord; Substance P; Tibial Fractures; Up-Regulation | 2015 |
Effects on Spatial Cognition and Nociceptive Behavior Following Peripheral Nerve Injury in Rats with Lesion of the Striatal Marginal Division Induced by Kainic Acid.
Topics: Animals; Behavior, Animal; Corpus Striatum; Excitatory Amino Acid Antagonists; Inflammation Mediators; Kainic Acid; Male; Maze Learning; Nociception; Pain; Peripheral Nerve Injuries; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Space Perception; Substance P | 2015 |
Sensory Neuropeptides and Endogenous Opioids Expression in Human Dental Pulp with Asymptomatic Inflammation: In Vivo Study.
Topics: Adolescent; Analgesics, Opioid; beta-Endorphin; Calcitonin Gene-Related Peptide; Child; Dental Pulp; Enkephalins; Female; Humans; Inflammation; Male; Methionine; Molar; Neuropeptides; Orthodontics; Pain; Pilot Projects; Radioimmunoassay; Substance P | 2015 |
Annular puncture with tumor necrosis factor-alpha injection enhances painful behavior with disc degeneration in vivo.
Topics: Animals; Annulus Fibrosus; Behavior, Animal; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Injections; Intervertebral Disc; Intervertebral Disc Degeneration; Lumbar Vertebrae; Male; Nerve Growth Factor; Pain; Punctures; Random Allocation; Rats; Rats, Sprague-Dawley; Substance P; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2016 |
Changes in the disposition of substance P in the rostral ventromedial medulla after inflammatory injury in the rat.
Topics: Actin Cytoskeleton; Animals; Disease Models, Animal; Freund's Adjuvant; Functional Laterality; Gene Expression Regulation; Hyperalgesia; Inflammation; Male; Medulla Oblongata; Mitogen-Activated Protein Kinase 6; Pain; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P; Tachykinins | 2016 |
The Bisphosphonates Clodronate and Etidronate Exert Analgesic Effects by Acting on Glutamate- and/or ATP-Related Pain Transmission Pathways.
Topics: Acetic Acid; Adenosine Triphosphate; Analgesics; Animals; Bone Density Conservation Agents; Capsaicin; Clodronic Acid; Etidronic Acid; Excitatory Amino Acid Agonists; Foscarnet; Glutamic Acid; Lumbar Vertebrae; Mice; Mice, Inbred BALB C; N-Methylaspartate; Pain; Sodium-Phosphate Cotransporter Proteins; Spinal Cord; Substance P | 2016 |
Role of capsaicin-sensitive nerves and tachykinins in mast cell tryptase-induced inflammation of murine knees.
Topics: Animals; Arthritis; Calcitonin Gene-Related Peptide; Capsaicin; Cytokines; Edema; Hyperalgesia; Knee Joint; Male; Mice, Inbred C57BL; Mice, Knockout; Neurogenic Inflammation; Pain; Protein Precursors; Receptor, PAR-2; Receptors, Neurokinin-1; Substance P; Tachykinins; Touch; TRPV Cation Channels; Tryptases | 2016 |
Substance P and sickle cell disease-a marker for pain and novel therapeutic approaches.
Topics: Anemia, Sickle Cell; Biomarkers; Humans; Morpholines; Pain; Substance P | 2016 |
Generation of a NK1R-CreER knockin mouse strain to study cells involved in Neurokinin 1 Receptor signaling.
Topics: Animals; Gene Expression Regulation; Gene Knock-In Techniques; Integrases; Mice; Neurons; Pain; Receptors, Neurokinin-1; Signal Transduction; Spinal Cord; Substance P | 2016 |
TRPA1, substance P, histamine and 5-hydroxytryptamine interact in an interdependent way to induce nociception.
Topics: Acetanilides; Animals; Histamine; Histamine H1 Antagonists; Isothiocyanates; Male; Oligonucleotides, Antisense; p-Methoxy-N-methylphenethylamine; Pain; Piperazines; Purines; Pyrilamine; Quinuclidines; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, Histamine H1; Receptors, Neurokinin-1; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Antagonists; Substance P; TRPA1 Cation Channel; TRPC Cation Channels | 2017 |
Nerve growth factor derivative NGF61/100 promotes outgrowth of primary sensory neurons with reduced signs of nociceptive sensitization.
Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Calcium; Ganglia, Spinal; Gene Expression Profiling; Humans; Nerve Growth Factor; Pain; Peptide Fragments; Primary Cell Culture; Rats; Receptors, Bradykinin; Sensory Receptor Cells; Substance P; TRPV Cation Channels; Up-Regulation | 2017 |
Distribution of hemokinin-1 in the rat trigeminal ganglion and trigeminal sensory nuclear complex.
Topics: Amino Acid Sequence; Animals; Antigens, Nuclear; Brain Stem; Guinea Pigs; Immunohistochemistry; Male; Nerve Tissue Proteins; Neurons; Pain; Pruritus; Rabbits; Rats; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn; Substance P; Tachykinins; Trigeminal Caudal Nucleus; Trigeminal Ganglion | 2017 |
Plasma concentrations of substance P and cortisol in beef calves after castration or simulated castration.
Topics: Animals; Behavior, Animal; Cattle; Hydrocortisone; Male; Orchiectomy; Pain; Pain Measurement; Random Allocation; Stress, Physiological; Substance P | 2008 |
Effect of a metabotropic glutamate receptor 5 antagonist, MPEP, on the nociceptive response induced by intrathecal injection of excitatory aminoacids, substance P, bradykinin or cytokines in mice.
Topics: Animals; Bradykinin; Cytokinins; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Injections, Spinal; Interleukin-1beta; Male; Mice; Nociceptors; Pain; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Substance P; Tumor Necrosis Factor-alpha | 2008 |
The VGF-derived peptide TLQP-21: a new modulatory peptide for inflammatory pain.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Embryo, Mammalian; Ganglia, Spinal; Inflammation; Male; Mice; Nerve Growth Factors; Neurons; Neuropeptides; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Substance P | 2008 |
Antinociceptive effect of the Polygala sabulosa hydroalcoholic extract in mice: evidence for the involvement of glutamatergic receptors and cytokine pathways.
Topics: Administration, Oral; Analgesics; Animals; Capsaicin; Cytokines; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Interleukin-1beta; Male; Mice; Pain; Pain Measurement; Plant Extracts; Polygala; Receptors, Glutamate; Receptors, Neurokinin-1; Substance P; Tumor Necrosis Factor-alpha | 2008 |
Acetaminophen prevents hyperalgesia in central pain cascade.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Dinoprostone; Hyperalgesia; Injections, Spinal; Male; Neurotransmitter Agents; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2008 |
Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by alpha2A-adrenoceptors: a mechanism of action distinct from morphine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Gene Expression Regulation; Injections, Spinal; Male; Morphine; Pain; Pain Measurement; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Neurokinin-1; Substance P | 2008 |
Participation of peripheral tachykinin NK1 receptors in the carrageenan-induced inflammation of the rat temporomandibular joint.
Topics: Animals; Carrageenan; Data Interpretation, Statistical; Extravasation of Diagnostic and Therapeutic Materials; Inflammation; Interleukin-1beta; Leukocyte Count; Male; Neurokinin-1 Receptor Antagonists; Pain; Peroxidase; Piperidines; Quinuclidines; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, Neurokinin-1; Serum Albumin, Radio-Iodinated; Substance P; Temporomandibular Joint Disorders; Tumor Necrosis Factor-alpha | 2009 |
Effect of the carboxyl-terminal of endokinins on SP-induced pain-related behavior.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Hot Temperature; Hyperalgesia; Male; Pain; Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Substance P; Tachykinins | 2009 |
Physiological evidence of a postsynaptic inhibition of the tail flick reflex by a cannabinoid receptor agonist.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoid Receptor Agonists; Hot Temperature; Male; Morpholines; Naphthalenes; Neural Inhibition; Neurotransmitter Agents; Nociceptors; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Reflex; Spinal Cord; Substance P; Synaptic Potentials; Tail; Time Factors | 2009 |
Large projection neurons in lamina I of the rat spinal cord that lack the neurokinin 1 receptor are densely innervated by VGLUT2-containing axons and possess GluR4-containing AMPA receptors.
Topics: Animals; Carrier Proteins; Cell Shape; Dendrites; Glutamic Acid; Immunohistochemistry; Interneurons; Male; Membrane Proteins; Nociceptors; Pain; Physical Stimulation; Posterior Horn Cells; Presynaptic Terminals; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Neurokinin-1; Spinothalamic Tracts; Substance P; Synaptic Transmission; Vesicular Glutamate Transport Protein 2 | 2008 |
Increased pain and neurogenic inflammation in mice deficient of neutral endopeptidase.
Topics: Animals; Cold Temperature; Edema; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Hindlimb; Hot Temperature; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Neprilysin; Neurogenic Inflammation; Pain; Pain Measurement; Physical Stimulation; Sciatic Nerve; Skin; Skin Temperature; Substance P | 2009 |
Degranulated mast cells in the skin of adults with self-injurious behavior and neurodevelopmental disorders.
Topics: Adult; Analysis of Variance; Biopsy; Case-Control Studies; Cell Degranulation; Female; Humans; Intellectual Disability; Male; Mast Cells; Microscopy, Confocal; Middle Aged; Pain; Pain Measurement; Physical Stimulation; Self-Injurious Behavior; Skin; Substance P | 2009 |
The role of graded nerve root compression on axonal damage, neuropeptide changes, and pain-related behaviors.
Topics: Animals; Axons; Biomechanical Phenomena; Elasticity; Ganglia, Spinal; Models, Theoretical; Neck Injuries; Nerve Growth Factors; Neuroglia; Neuropeptides; Nociceptors; Pain; Radiculopathy; Rats; Receptors, Nerve Growth Factor; Substance P; Viscosity; Whiplash Injuries | 2008 |
Joint distraction magnitude is associated with different behavioral outcomes and substance P levels for cervical facet joint loading in the rat.
Topics: Animals; Behavior, Animal; Cervical Vertebrae; Enzyme-Linked Immunosorbent Assay; Forelimb; Ganglia, Spinal; Hyperalgesia; Male; Pain; Pain Measurement; Pain Threshold; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Shoulder; Spinal Cord; Substance P; Zygapophyseal Joint | 2009 |
Experimental forearm immobilization in humans reduces capsaicin-induced pain and flare.
Topics: Adolescent; Adult; Area Under Curve; Capsaicin; Female; Forearm; Hand; Humans; Immobilization; Male; Pain; Pain Measurement; Regional Blood Flow; Skin; Skin Physiological Phenomena; Skin Temperature; Substance P; Time Factors; Young Adult | 2009 |
Primary sensory neuronal expression of SLURP-1, an endogenous nicotinic acetylcholine receptor ligand.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antigens, Ly; Calcitonin Gene-Related Peptide; Ganglia, Spinal; Immunohistochemistry; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Nociceptors; Pain; Posterior Horn Cells; Presynaptic Terminals; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; RNA, Messenger; Sensory Receptor Cells; Substance P; Synaptic Transmission; Synaptic Vesicles; Urokinase-Type Plasminogen Activator | 2009 |
Spinal substance P and neurokinin-1 increase with high repetition reaching.
Topics: Animals; Cumulative Trauma Disorders; Female; Forelimb; Immunohistochemistry; Pain; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2009 |
The c-kit signaling pathway is involved in the development of persistent pain.
Topics: Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Constriction, Pathologic; Female; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Pain; Pain Measurement; Physical Stimulation; Point Mutation; Proto-Oncogene Proteins c-kit; Radioimmunoassay; Rhizotomy; Signal Transduction; Spinal Cord; Substance P | 2009 |
Propofol/alfentanil and propofol/ketamine procedural sedation in children with acute lymphoblastic leukaemia: safety, efficacy and their correlation with pain neuromediator expression.
Topics: Adolescent; Alfentanil; Anxiety; Child; Child, Preschool; Conscious Sedation; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Ketamine; Male; Nerve Growth Factor; Pain; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Propofol; Prospective Studies; Spinal Puncture; Substance P; Treatment Outcome | 2010 |
Nonselective innervation of lamina I projection neurons by cocaine- and amphetamine-regulated transcript peptide (CART)-immunoreactive fibres in the rat spinal dorsal horn.
Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Dendrites; Galanin; Immunohistochemistry; Male; Microscopy, Electron, Transmission; Nerve Tissue Proteins; Nociceptors; Pain; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Wistar; Spinal Nerve Roots; Substance P | 2009 |
Substance P enhances excitatory synaptic transmission on spinally projecting neurons in the rostral ventromedial medulla after inflammatory injury.
Topics: Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Indoles; Inflammation; Male; Maleimides; Medulla Oblongata; Neural Pathways; Neurons; Neurotransmitter Agents; Pain; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Serotonin; Substance P; Sulfonamides; Synaptic Transmission | 2009 |
Intrathecal substance P augments morphine-induced antinociception: possible relevance in the production of substance P N-terminal fragments.
Topics: Animals; Antibodies; Capsaicin; Dose-Response Relationship, Drug; Drug Synergism; Glycopeptides; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Neprilysin; Pain; Pain Measurement; Peptide Fragments; Protease Inhibitors; Spinal Cord; Substance P | 2009 |
Dissociation of the opioid receptor mechanisms that control mechanical and heat pain.
Topics: Analgesia; Analgesics, Opioid; Animals; Gene Knock-In Techniques; Hot Temperature; Male; Mechanoreceptors; Mice; Mice, Inbred C57BL; Morphine; Nociceptors; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Substance P; TRPV Cation Channels | 2009 |
Spinal ERK activation via NO-cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide.
Topics: Analgesics; Animals; Behavior, Animal; Butadienes; Central Nervous System Stimulants; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Injections, Spinal; Isoindoles; Male; Mice; Mice, Inbred Strains; Morphine Derivatives; Nitric Oxide; Nitriles; Nociceptors; Pain; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Receptors, Tachykinin; Specific Pathogen-Free Organisms; Spinal Cord; Stereoisomerism; Substance P | 2009 |
Substance P and beta endorphin mediate electroacupuncture induced analgesic activity in mouse cancer pain model.
Topics: Acupuncture Analgesia; Acupuncture Points; Animals; beta-Endorphin; Cell Line, Tumor; Disease Models, Animal; Electroacupuncture; Humans; Male; Mice; Mice, Inbred BALB C; Neoplasms; Pain; Pain Management; Pain Threshold; Substance P | 2009 |
Detection of pain-related molecules in the subchondral bone of osteoarthritic knees.
Topics: Aged; Arthroplasty, Replacement, Knee; Biomarkers; Cartilage, Articular; Cyclooxygenase 2; Female; Femur; Humans; Immunohistochemistry; Knee Joint; Magnetic Resonance Imaging; Male; Menisci, Tibial; Middle Aged; Osteoarthritis, Knee; Pain; Substance P; Tubulin; Tumor Necrosis Factor-alpha | 2009 |
Unilateral focal burn injury is followed by long-lasting bilateral allodynia and neuronal hyperexcitability in spinal cord dorsal horn.
Topics: Action Potentials; Analysis of Variance; Animals; Brain Injuries; Calcitonin Gene-Related Peptide; CD11b Antigen; Disease Models, Animal; Functional Laterality; Hyperesthesia; Male; Microglia; p38 Mitogen-Activated Protein Kinases; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Posterior Horn Cells; Rats; Spinal Cord; Substance P | 2010 |
Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice.
Topics: Aldehydes; Animals; Calcitonin Gene-Related Peptide; Colitis; Colon; Cysteine Proteinase Inhibitors; Efferent Pathways; Female; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Nociceptors; Pain; Plant Oils; Pregnancy; Proto-Oncogene Proteins c-fos; Receptor, PAR-2; RNA, Messenger; Spinal Cord; Substance P; Transient Receptor Potential Channels; TRPA1 Cation Channel; Visceral Afferents | 2010 |
Effects of neurokinin-1 receptor agonism and antagonism in the rostral ventromedial medulla of rats with acute or persistent inflammatory nociception.
Topics: Animals; Capsaicin; Central Nervous System Agents; Freund's Adjuvant; Hot Temperature; Male; Medulla Oblongata; Mustard Plant; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Piperidines; Plant Oils; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Time Factors | 2010 |
Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn.
Topics: Afferent Pathways; Animals; Ankyrins; Axons; Biomarkers; Brain Mapping; Calcium Channels; Dendrites; Immunohistochemistry; Microscopy, Immunoelectron; Nerve Fibers, Unmyelinated; Nociceptors; Pain; Plant Lectins; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Rhizotomy; Sensory Receptor Cells; Substance P; Synaptic Vesicles; Trigeminal Caudal Nucleus; Trigeminal Ganglion; Trigeminal Nerve; Trigeminal Nuclei; TRPA1 Cation Channel; TRPC Cation Channels | 2010 |
Cannabinoid CB1 receptor facilitation of substance P release in the rat spinal cord, measured as neurokinin 1 receptor internalization.
Topics: Animals; Capsaicin; Electric Stimulation; GABA-B Receptor Antagonists; Injections, Spinal; Male; Morpholines; Neurons; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Receptors, Neurokinin-1; Receptors, Opioid, mu; Sensory System Agents; Spinal Cord; Spinal Nerve Roots; Substance P; TRPV Cation Channels | 2010 |
Expression of sensory neuropeptides in tendon is associated with failed healing and activity-related tendon pain in collagenase-induced tendon injury.
Topics: Animals; Calcinosis; Calcitonin Gene-Related Peptide; Chondrocytes; Collagenases; Gait; Male; Pain; Patellar Ligament; Rats; Rats, Sprague-Dawley; Substance P; Tendinopathy; Wound Healing | 2010 |
[Correlation between activation of L5-S2 spinal cord astrocytes and effect of substance P in chronic prostatitis pain].
Topics: Animals; Astrocytes; Chronic Disease; Male; Nitric Oxide Synthase Type II; Pain; Prostatitis; Rats; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2009 |
Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids.
Topics: Anemia, Sickle Cell; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Agonists; Cannabinoids; Cyclohexanols; Disease Models, Animal; Female; Hemoglobin, Sickle; Humans; Hyperalgesia; Male; Mice; Mice, Knockout; Mice, Transgenic; Morphine; Neuroglia; Pain; Receptors, Opioid, mu; Recombinant Proteins; Skin; Spinal Cord; Substance P | 2010 |
Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Fentanyl; Freund's Adjuvant; Histamine Agonists; Hyperalgesia; Inflammation; Male; Methylhistamines; Mice; Naloxone; Pain; Piperidines; Receptors, Histamine H3; Skin; Substance P | 2010 |
Characterization of intrathecally administered hemokinin-1-induced nociceptive behaviors in mice.
Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Lumbar Vertebrae; Male; Mice; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Pain; Pain Measurement; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Spinal Nerves; Substance P; Synaptic Transmission; Tachykinins; Time Factors | 2010 |
Attenuation of pain and inflammation in adjuvant-induced arthritis by the proteasome inhibitor MG132.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Infectious; Biomarkers; Bone Density; Calcitonin Gene-Related Peptide; Cysteine Proteinase Inhibitors; DNA; Female; Joints; Leupeptins; Mycobacterium; Mycobacterium Infections; NF-kappa B; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Inbred Lew; Substance P | 2010 |
Peripheral sensitization of sensory neurons.
Topics: Animals; Cells, Cultured; Female; Ganglia, Spinal; Immunohistochemistry; Inflammation; Microscopy, Video; Nociceptors; Pain; Rats; Rats, Long-Evans; Receptors, Neurokinin-1; Sensory Receptor Cells; Substance P | 2010 |
Increased morphine analgesia and reduced side effects in mice lacking the tac1 gene.
Topics: Analgesics, Opioid; Animals; Behavior, Addictive; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Naloxone; Narcotic Antagonists; Neurokinin A; Pain; Pain Measurement; Respiratory Insufficiency; Substance P; Tachykinins | 2010 |
Normative values of substance P and neurokinin A in neonates.
Topics: Age Factors; Biomarkers; Female; Humans; Infant, Newborn; Neurokinin A; Pain; Pregnancy; Premature Birth; Reference Values; Substance P | 2010 |
A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model.
Topics: Analysis of Variance; Animals; Bradykinin; Calcitonin Gene-Related Peptide; Glutamic Acid; Osteoarthritis, Knee; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Tetrahydronaphthalenes; TRPV Cation Channels | 2010 |
Antinociceptive effect of vinpocetine--a comprehensive survey.
Topics: Acid Phosphatase; Analgesics; Animals; Calcitonin Gene-Related Peptide; Densitometry; Formaldehyde; Male; Nerve Growth Factor; Neuroprotective Agents; Pain; Pain Measurement; Phosphoric Monoester Hydrolases; Rats; Rats, Wistar; Spinal Cord; Substance P; Vinca Alkaloids | 2010 |
Plasticity of hyperpolarization-activated and cyclic nucleotid-gated cation channel subunit 2 expression in the spinal dorsal horn in inflammatory pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Freund's Adjuvant; Functional Laterality; Gene Expression Regulation; Hyperalgesia; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Inflammation; Ion Channels; Male; Microscopy, Confocal; Pain; Pain Measurement; Posterior Horn Cells; Potassium Channels; Presynaptic Terminals; Rats; Rats, Inbred WKY; Spinal Cord; Substance P | 2010 |
[Substance P].
Topics: Dermatitis, Atopic; Humans; Immunoenzyme Techniques; Mood Disorders; Pain; Pneumonia, Aspiration; Substance P | 2010 |
Delta opioid receptor-mediated analgesia is not altered in preprotachykinin A knockout mice.
Topics: Analgesia; Animals; Behavior, Animal; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Neurons; Oligopeptides; Pain; Pain Measurement; Protein Precursors; Receptors, Opioid, delta; Substance P; Tachykinins | 2010 |
Spatiotemporal CCR1, CCL3(MIP-1α), CXCR4, CXCL12(SDF-1α) expression patterns in a rat spinal cord injury model of posttraumatic neuropathic pain.
Topics: Animals; Biomarkers; Blotting, Western; Chemokine CCL3; Chemokine CXCL12; Disease Models, Animal; Immunohistochemistry; Male; Pain; Pain Threshold; Random Allocation; Rats; Receptors, Calcitonin Gene-Related Peptide; Receptors, CCR1; Receptors, CXCR4; Regression Analysis; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord Injuries; Substance P; TRPV Cation Channels | 2011 |
A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain.
Topics: Analysis of Variance; Animals; DNA Primers; Genotype; Hyperalgesia; Immunohistochemistry; In Situ Hybridization; Mice; Mice, Transgenic; Microscopy, Fluorescence; Models, Neurological; Pain; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Sensory Receptor Cells; Substance P; Vesicular Glutamate Transport Protein 2 | 2011 |
The analgesic effects and mechanisms of orally administered eugenol.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Brain; Disease Models, Animal; Eugenol; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Receptors, Serotonin; Substance P | 2011 |
Inhibition of ERK phosphorylation by substance P N-terminal fragment decreases capsaicin-induced nociceptive response.
Topics: Animals; Behavior, Animal; Capsaicin; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Injections, Spinal; Male; MAP Kinase Signaling System; Mice; Pain; Pain Measurement; Peptide Fragments; Phosphorylation; Protein Kinase Inhibitors; Substance P | 2011 |
Chili anyone?
Topics: Analgesics; Capsaicin; Capsicum; Food-Drug Interactions; Humans; Pain; Substance P | 2011 |
Substance P and calcitonin gene related peptide mediate pain in chronic pancreatitis and their expression is driven by nerve growth factor.
Topics: Animals; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Drug Evaluation, Preclinical; Gene Expression Regulation; Injections, Spinal; Male; Nerve Growth Factor; Nociceptive Pain; Pain; Pain Measurement; Pancreatitis, Chronic; Peptide Fragments; Rats; Rats, Sprague-Dawley; Substance P | 2011 |
Potential mechanisms for hypoalgesia induced by anti-nerve growth factor immunoglobulin are identified using autoimmune nerve growth factor deprivation.
Topics: Age Factors; Animals; Antibodies, Monoclonal, Humanized; Calcitonin Gene-Related Peptide; Cytochromes c; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Ganglia, Spinal; Glycoproteins; Immunoglobulins; Inflammation; Male; NAV1.8 Voltage-Gated Sodium Channel; Nerve Growth Factor; Nerve Tissue Proteins; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Sodium Channels; Substance P | 2011 |
Hip joint pain in spastic dislocation: aetiological aspects.
Topics: Adolescent; Cerebral Palsy; Child; Child, Preschool; Disability Evaluation; Female; Hip Dislocation; Hip Joint; Humans; Infant; Ligaments; Male; Nerve Fibers; Pain; Pain Measurement; S100 Proteins; Severity of Illness Index; Statistics, Nonparametric; Substance P | 2011 |
Determination of specific neuropeptides modulation time course in a rat model of osteoarthritis pain by liquid chromatography ion trap mass spectrometry.
Topics: Animals; Calcitonin Gene-Related Peptide; Chromatography, Liquid; Disease Models, Animal; Dynorphins; Enzyme Inhibitors; Humans; Iodoacetic Acid; Knee Joint; Male; Neuropeptides; Osteoarthritis; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Tandem Mass Spectrometry; Time Factors | 2011 |
Activation of spinal mu- and delta-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.
Topics: Animals; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Formaldehyde; Injections, Spinal; Male; Mice; Mice, Knockout; Neurons; Neurons, Afferent; Oligopeptides; Pain; Pain Measurement; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Substance P; Tachykinins | 2011 |
Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study.
Topics: Animals; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Related Peptide; Cells, Cultured; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; MAP Kinase Signaling System; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, trkB; Sensory Receptor Cells; Substance P; TRPV Cation Channels; Tumor Necrosis Factor-alpha; Up-Regulation | 2011 |
Suppression of pain and joint destruction by inhibition of the proteasome system in experimental osteoarthritis.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Cartilage, Articular; Cysteine Proteinase Inhibitors; Female; Ganglia, Spinal; Knee Joint; Leupeptins; Matrix Metalloproteinase 3; Osteoarthritis; Pain; Pain Measurement; Rats; Rats, Inbred Lew; Substance P | 2012 |
Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia.
Topics: Analgesics; Animals; Calcium; Capsaicin; CHO Cells; Cricetinae; Disease Models, Animal; Formaldehyde; Glycyrrhetinic Acid; Hot Temperature; Humans; Hyperalgesia; Inflammation; Ligation; Male; Neuralgia; Neurokinin A; Neurokinin B; Pain; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Sciatic Nerve; Substance P | 2011 |
Negative pressure wound therapy-associated tissue trauma and pain: a controlled in vivo study comparing foam and gauze dressing removal by immunohistochemistry for substance P and calcitonin gene-related peptide in the wound edge.
Topics: Animals; Bandages; Calcitonin Gene-Related Peptide; Immunohistochemistry; Negative-Pressure Wound Therapy; Pain; Substance P; Swine; Wounds and Injuries | 2011 |
Dragon's blood inhibits chronic inflammatory and neuropathic pain responses by blocking the synthesis and release of substance P in rats.
Topics: Analgesics, Non-Narcotic; Animals; Bradykinin; Capsaicin; Carrageenan; Chalcone; Cyclooxygenase 2; Drugs, Chinese Herbal; Ganglia, Spinal; Inflammation; Male; Pain; Plant Extracts; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Sciatic Nerve; Substance P; Tachykinins | 2012 |
Supraspinal injection of Substance P attenuates allodynia and hyperalgesia in a rat model of inflammatory pain.
Topics: Animals; Carrageenan; Dose-Response Relationship, Drug; Hyperalgesia; Infusions, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Naloxone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Nociception; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2012 |
Antinociceptive effects of galanin in the nucleus accumbens of rats.
Topics: Analgesics; Animals; Galanin; Hot Temperature; Injections, Intraventricular; Male; Nucleus Accumbens; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Galanin; Substance P | 2012 |
Regulation of peripheral clock to oscillation of substance P contributes to circadian inflammatory pain.
Topics: Animals; ARNTL Transcription Factors; Circadian Rhythm; CLOCK Proteins; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Pain; Receptors, Neurokinin-1; Substance P; Suprachiasmatic Nucleus | 2012 |
miR-203 regulates nociceptive sensitization after incision by controlling phospholipase A2 activating protein expression.
Topics: Animals; Conditioning, Psychological; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Pain; Protein Precursors; Proteins; Receptors, Neurokinin-1; Signal Transduction; Substance P; Tachykinins | 2012 |
A new rat model of bone cancer pain produced by rat breast cancer cells implantation of the shaft of femur at the third trochanter level.
Topics: Animals; Behavior, Animal; Bone Neoplasms; Cell Line, Tumor; Disease Models, Animal; Female; Femur; Humans; Magnetic Resonance Imaging; Neoplasm Transplantation; Pain; Rats; Substance P; TRPV Cation Channels | 2013 |
Reduced aversion to oral capsaicin following neurotoxic destruction of superficial medullary neurons expressing NK-1 receptors.
Topics: Administration, Oral; Animals; Capsaicin; Cervical Vertebrae; Injections, Intraventricular; Irritants; Male; Medulla Oblongata; Neurons; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Solutions; Spinal Cord; Substance P | 2002 |
Upregulation of neurokinin-1 receptor expression in rat spinal cord by an N-terminal metabolite of substance P.
Topics: Afferent Pathways; Animals; Capsaicin; Dose-Response Relationship, Drug; Ganglia, Spinal; Immunohistochemistry; Inflammation; Isomerism; Male; Pain; Peptide Fragments; Posterior Horn Cells; Presynaptic Terminals; Protein Precursors; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Tachykinins; Up-Regulation | 2002 |
Two major distinct subpopulations of neurokinin-3 receptor-expressing neurons in the superficial dorsal horn of the rat spinal cord.
Topics: Afferent Pathways; Animals; Cell Count; gamma-Aminobutyric Acid; Immunohistochemistry; Nitric Oxide; Nitric Oxide Synthase; Opioid Peptides; Pain; Posterior Horn Cells; Rats; Rats, Wistar; Receptors, Neurokinin-3; Receptors, Opioid, mu; Substance P; Synaptic Transmission | 2002 |
Temporomandibular joint nociception: effects of capsaicin on substance P-like immunoreactivity in the rabbit brain stem.
Topics: Analysis of Variance; Animals; Antibodies, Monoclonal; Brain Stem; Capsaicin; Cervical Plexus; Female; Image Processing, Computer-Assisted; Immunohistochemistry; Injections, Intra-Articular; Neural Pathways; Neurons, Afferent; Neurotransmitter Agents; Nociceptors; Pain; Rabbits; Statistics as Topic; Substance P; Temporomandibular Joint; Trigeminal Caudal Nucleus; Trigeminal Nuclei; Trigeminal Nucleus, Spinal | 2002 |
CB1 cannabinoid receptors in amphibian spinal cord: relationships with some nociception markers.
Topics: Animals; Cannabinoid Receptor Modulators; Cannabinoids; Female; Pain; Receptors, Cannabinoid; Receptors, Drug; Spinal Cord; Substance P; Xenopus laevis | 2002 |
BDNF modulates sensory neuron synaptic activity by a facilitation of GABA transmission in the dorsal horn.
Topics: Afferent Pathways; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; gamma-Aminobutyric Acid; Ganglia, Spinal; Injections, Spinal; Male; Narcotic Antagonists; Neural Inhibition; Pain; Pain Threshold; Posterior Horn Cells; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid; Substance P; Synaptic Transmission | 2002 |
Somatic nociception activates NK1 receptors in the nucleus tractus solitarii to attenuate the baroreceptor cardiac reflex.
Topics: Animals; Baroreflex; Bicuculline; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Microinjections; Neural Inhibition; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Pain Measurement; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Neurokinin-1; Solitary Nucleus; Substance P | 2002 |
Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways.
Topics: Animals; Brain Stem; Efferent Pathways; Hyperalgesia; Immunohistochemistry; Immunotoxins; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neural Inhibition; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Ribosome Inactivating Proteins, Type 1; Saporins; Serotonin Antagonists; Substance P; Synaptic Transmission | 2002 |
Vanilloid receptor subtype-1 (VR1) is specifically localized to taste papillae.
Topics: Animals; Axons; Calcitonin Gene-Related Peptide; Capsaicin; Immunohistochemistry; Male; Pain; Rats; Rats, Wistar; Receptors, Drug; Substance P; Taste; Taste Buds; Tongue | 2002 |
Endomorphin-2 is not released from rat spinal dorsal horn in response to intraplantar formalin.
Topics: Animals; Female; Formaldehyde; Genes, fos; Hindlimb; Male; Oligopeptides; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Substance P | 2002 |
C-fiber modulation of the rat type I slowly adapting mechanoreceptor.
Topics: Action Potentials; Adaptation, Biological; Animals; Axons; Calcitonin Gene-Related Peptide; Electric Stimulation; Evoked Potentials; Immunohistochemistry; Mechanoreceptors; Nerve Fibers, Unmyelinated; Neural Conduction; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Skin; Substance P; Synaptic Transmission; Touch | 2002 |
Bone cancer pain.
Topics: Animals; Biomarkers; Bone Neoplasms; Disease Models, Animal; Mice; Osteolysis; Pain; Sarcoma, Experimental; Spinal Cord; Substance P | 2003 |
Nociception in persistent pancreatitis in rats: effects of morphine and neuropeptide alterations.
Topics: Amylases; Analgesics, Opioid; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Immunohistochemistry; Lipase; Male; Morphine; Neuropeptides; Organotin Compounds; Pain; Pain Measurement; Pancreas; Pancreatitis; Physical Stimulation; Rats; Rats, Inbred Lew; Substance P | 2003 |
In vivo pain-inhibitory role of nociceptin/orphanin FQ in spinal cord.
Topics: Animals; Blotting, Western; Capsaicin; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hot Temperature; Immunohistochemistry; Injections, Spinal; Male; Mice; Mice, Knockout; N-Methylaspartate; Neurokinin-1 Receptor Antagonists; Nociceptin; Opioid Peptides; Pain; Pain Measurement; Pressure; Receptors, Neurokinin-1; Reflex; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Substance P; Synaptic Membranes; Synaptic Transmission | 2003 |
Galanin expression in adult human dorsal root ganglion neurons: initial observations.
Topics: Adult; Aged; Aged, 80 and over; Calcitonin Gene-Related Peptide; Cell Size; Female; Galanin; Ganglia, Spinal; Headache; Herpes Zoster; Humans; Male; Middle Aged; Neurons, Afferent; Nociceptors; Pain; Peripheral Nerve Injuries; Peripheral Nerves; Peripheral Nervous System Diseases; Postmortem Changes; RNA, Messenger; Substance P | 2003 |
Long-term effects of decreased noradrenergic central nervous system innervation on pain behavior and opioid antinociception.
Topics: Analgesics, Opioid; Animals; Antibodies, Monoclonal; Behavior, Animal; Biphenyl Compounds; Central Nervous System; Denervation; Disease Models, Animal; Disease Progression; Female; Hyperalgesia; Immunohistochemistry; Immunotoxins; Injections, Intraventricular; Injections, Spinal; Lumbosacral Region; Male; Morphine; Norepinephrine; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Cord; Substance P; Time | 2003 |
The algogenic-induced nociceptive flexion test in mice: studies on sensitivity of the test and stress on animals.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Bites and Stings; Bradykinin; Corticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Epoprostenol; Formaldehyde; Immobilization; Male; Mice; Pain; Pain Measurement; Peripheral Nervous System; Prostaglandins F; Reflex; Sensitivity and Specificity; Stress, Physiological; Substance P | 2003 |
Antinociceptive mechanisms of orally administered decursinol in the mouse.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Analgesics; Animals; Benzopyrans; Butyrates; Cyproheptadine; Dose-Response Relationship, Drug; Glutamic Acid; Histamine H2 Antagonists; Interferon-gamma; Interleukin-1; Male; Methysergide; Mice; Mice, Inbred ICR; Models, Chemical; Naloxone; Narcotic Antagonists; Pain; Piperidines; Protein Kinase C; Ranitidine; Receptors, Adrenergic; Receptors, Histamine; Receptors, Purinergic P1; Receptors, Serotonin; Serotonin Antagonists; Substance P; Theobromine; Tumor Necrosis Factor-alpha; Xanthines; Yohimbine | 2003 |
Direct interstitial infusion of NK1-targeted neurotoxin into the spinal cord: a computational model.
Topics: Chronic Disease; Extracellular Space; Humans; Models, Biological; Neurotoxins; Pain; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2003 |
Nociception attenuates parasympathetic but not sympathetic baroreflex via NK1 receptors in the rat nucleus tractus solitarii.
Topics: Animals; Baroreflex; GABA Agonists; Heart; Hindlimb; Isonicotinic Acids; Male; Microinjections; Nociceptors; Pain; Parasympathetic Nervous System; Physical Stimulation; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Solitary Nucleus; Substance P; Sympathetic Nervous System; Tachycardia; Vagus Nerve | 2003 |
Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Methionine; Formaldehyde; Glycopeptides; Kidney; Leucine; Male; Membrane Proteins; Molecular Sequence Data; Naltrexone; Neprilysin; Pain; Pain Measurement; Prostate; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Salivary Proteins and Peptides; Spinal Cord; Submandibular Gland; Substance P; Thiorphan; Wounds and Injuries | 2003 |
Molecular plasticity of primary nociceptive neurons: relations of the NGF-c-jun system to neurotomy and chronic pain.
Topics: Animals; Atrophy; Calcitonin Gene-Related Peptide; Chronic Disease; Female; Functional Laterality; Ganglia, Spinal; Male; Models, Neurological; Nerve Growth Factor; Neuronal Plasticity; Neurons; Nociceptors; Pain; Proto-Oncogene Proteins c-jun; Rats; Substance P; Vincristine | 2003 |
Somatosensory organization and behavior in naked mole-rats: II. Peripheral structures, innervation, and selective lack of neuropeptides associated with thermoregulation and pain.
Topics: Afferent Pathways; Animals; Body Temperature Regulation; Calcitonin Gene-Related Peptide; Ganglia, Spinal; Hair; Hair Follicle; Merkel Cells; Mole Rats; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Skin; Substance P; Touch; Trigeminal Ganglion; Vibrissae | 2003 |
Vanilloid receptor VR1-positive afferents are distributed differently at different levels of the rat lumbar spinal cord.
Topics: Animals; Biomarkers; Fluorescent Antibody Technique; Lumbar Vertebrae; Male; Microscopy, Confocal; Nociceptors; Pain; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Drug; Spinal Nerve Roots; Substance P; Synaptic Transmission; Visceral Afferents | 2003 |
Antinociceptive profiles of crude extract from roots of Angelica gigas NAKAI in various pain models.
Topics: Administration, Oral; Analgesics; Angelica; Animals; Capsaicin; Cytokines; Excitatory Amino Acids; Formaldehyde; Hot Temperature; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Plant Extracts; Plant Roots; Postural Balance; Reaction Time; Substance P | 2003 |
Spinal upregulation of the nitric oxide synthase-interacting protein NOSIP in a rat model of inflammatory pain.
Topics: Animals; Carrier Proteins; Disease Models, Animal; Freund's Adjuvant; Functional Laterality; Ganglia, Spinal; Hindlimb; Immunohistochemistry; Inflammation; Injections; Lectins; Male; Pain; Pain Measurement; Phosphopyruvate Hydratase; Rats; Rats, Wistar; Spinal Cord; Substance P; Time Factors; Ubiquitin-Protein Ligases; Up-Regulation | 2003 |
Visceral pain evoked by intra-arterial injection of substance P.
Topics: Central Nervous System; Humans; Injections, Intra-Arterial; Muscles; Pain; Substance P; Visceral Pain | 1962 |
Acute pancreatitis results in referred mechanical hypersensitivity and neuropeptide up-regulation that can be suppressed by the protein kinase inhibitor k252a.
Topics: Animals; Arginine; Calcitonin Gene-Related Peptide; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Ganglia, Spinal; Indole Alkaloids; Male; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Pancreatitis, Acute Necrotizing; Phosphorylation; Physical Stimulation; Protein Kinase C; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptor, trkA; RNA, Messenger; Spinal Cord; Substance P; Tachykinins; Up-Regulation | 2003 |
Galectin-1 is involved in the potentiation of neuropathic pain in the dorsal horn.
Topics: Animals; Antibodies; Axotomy; Behavior, Animal; Blotting, Western; Carrier Proteins; Cell Count; Functional Laterality; Galectin 1; Ganglia, Spinal; Humans; Immunohistochemistry; In Situ Hybridization; Ligation; Locomotion; Lumbosacral Region; Male; Membrane Proteins; Pain; Pain Threshold; Posterior Horn Cells; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, trkA; RNA, Messenger; Sciatic Nerve; Spinal Cord; Statistics, Nonparametric; Substance P; Time Factors; Up-Regulation | 2003 |
Antinociceptive effects of ginsenosides injected intracerebroventricularly or intrathecally in substance P-induced pain model.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Ginsenosides; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Panax; Phytotherapy; Plant Extracts; Substance P | 2003 |
The effect of treatment with BRX-220, a co-inducer of heat shock proteins, on sensory fibers of the rat following peripheral nerve injury.
Topics: Animals; Axotomy; Blotting, Western; Calcitonin Gene-Related Peptide; Electric Stimulation; Ganglia, Spinal; HSP70 Heat-Shock Proteins; Hydroxylamines; Lectins; Male; Neurons, Afferent; Neuroprotective Agents; Organ Culture Techniques; Pain; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; Spinal Nerves; Substance P | 2003 |
Substance P microinjected into the periaqueductal gray matter induces antinociception and is released following morphine administration.
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Dialysis; Dose-Response Relationship, Drug; Drug Interactions; Male; Microinjections; Morphine; Narcotics; Pain; Pain Measurement; Periaqueductal Gray; Potassium; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P | 2004 |
Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Formaldehyde; Hot Temperature; Hyperalgesia; Inflammation; Mice; Mice, Knockout; Neurons; Pain; Reaction Time; Substance P; Thionucleotides | 2004 |
Nonopioidergic mechanism mediating morphine-induced antianalgesia in the mouse spinal cord.
Topics: Analgesia; Animals; beta-Endorphin; Dizocilpine Maleate; Drug Interactions; Drug Tolerance; Dynorphins; Enkephalins; Male; Mice; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance P | 2004 |
Retargeted clostridial endopeptidases: inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain.
Topics: Action Potentials; Animals; Botulinum Toxins, Type A; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Embryo, Mammalian; Endopeptidases; Ganglia, Spinal; Glycine; Immunotoxins; In Vitro Techniques; Membrane Proteins; Mice; Nerve Fibers, Unmyelinated; Nerve Tissue Proteins; Neuromuscular Agents; Neurons; Neurotransmitter Agents; Pain; Pain Measurement; Reaction Time; Spinal Cord; Substance P; Synaptic Transmission; Synaptosomal-Associated Protein 25; Time Factors | 2004 |
Substance P axons and sensory threshold increase in burn-graft human skin.
Topics: Adult; Axons; Burns; Dermatologic Surgical Procedures; Humans; Middle Aged; Nerve Regeneration; Nociceptors; Pain; Pruritus; Recovery of Function; Sensory Thresholds; Skin; Skin Transplantation; Substance P; Touch; Vibration | 2004 |
Effects of a chromogranin-derived peptide (CgA 47-66) in the writhing nociceptive response induced by acetic acid in rats.
Topics: Acetic Acid; Animals; Calcitonin Gene-Related Peptide; Cardiovascular Agents; Chromogranin A; Chromogranins; Corticotropin-Releasing Hormone; Diltiazem; Dose-Response Relationship, Drug; Indomethacin; Male; Pain; Pain Management; Peptide Fragments; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Substance P | 2004 |
Sustained potentiation by substance P of NMDA-activated current in rat primary sensory neurons.
Topics: Animals; Benzylamines; Calcium Signaling; Cell Membrane; Cells, Cultured; Chelating Agents; Chronic Disease; Dose-Response Relationship, Drug; Drug Synergism; Egtazic Acid; Enzyme Inhibitors; Ganglia, Spinal; Membrane Potentials; Models, Biological; N-Methylaspartate; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Pain; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Substance P; Sulfonamides | 2004 |
Substance P release in the cat spinal cord upon afferent C-fibre stimulation is not attenuated by clonidine at analgesic doses.
Topics: Afferent Pathways; Analgesics; Animals; Cats; Clonidine; Dose-Response Relationship, Drug; Down-Regulation; Electric Stimulation; Lidocaine; Nerve Fibers, Unmyelinated; Nociceptors; Pain; Presynaptic Terminals; Spinal Cord; Substance P; Synaptic Transmission | 2004 |
Spinal neurons involved in the generation of at-level pain following spinal injury in the rat.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Grooming; Immunohistochemistry; Immunotoxins; N-Glycosyl Hydrolases; Neurotoxins; Pain; Plant Proteins; Posterior Horn Cells; Rats; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Self Mutilation; Skin; Spinal Cord; Spinal Cord Injuries; Substance P | 2004 |
Transgenic mice ectopically expressing HOXA5 in the dorsal spinal cord show structural defects of the cervical spinal cord along with sensory and motor defects of the forelimb.
Topics: Animals; Behavior, Animal; Butorphanol; Cell Count; Cloning, Molecular; Embryo, Mammalian; Forelimb; Gene Expression Regulation, Developmental; Homeodomain Proteins; Humans; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Mice; Mice, Knockout; Motor Activity; Narcotics; Neural Pathways; Neurokinin B; Pain; Pain Threshold; Phosphoproteins; Psychomotor Performance; Reaction Time; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensation Disorders; Spinal Cord; Substance P; Transcription Factors | 2004 |
Effects of tegaserod on Fos, substance P and calcitonin gene-related peptide expression induced by colon inflammation in lumbarsacral spinal cord.
Topics: Animals; Calcitonin Gene-Related Peptide; Colitis; Disease Models, Animal; Gastrointestinal Agents; Indoles; Male; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Visceral Afferents | 2004 |
Substance P and neurotensin are up-regulated in the lumbar spinal cord of animals with neuropathic pain.
Topics: Animals; Constriction; Disease Models, Animal; Electrophysiology; Hindlimb; Lumbar Vertebrae; Male; Neurotensin; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; Substance P; Up-Regulation | 2004 |
Partial sciatic nerve transection causes redistribution of pain-related peptides and lowers withdrawal threshold.
Topics: Animals; Disease Models, Animal; Female; Ganglia, Spinal; Lumbosacral Region; Neuropeptides; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Somatostatin; Substance P | 2004 |
Substance P (NK1) and somatostatin (sst2A) receptor immunoreactivity in NTS-projecting rat dorsal horn neurones activated by nociceptive afferent input.
Topics: Afferent Pathways; Animals; Cardiovascular Physiological Phenomena; Cell Size; Cholera Toxin; Fluorescent Dyes; Immunohistochemistry; Male; Nociceptors; Pain; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Somatostatin; Respiratory Physiological Phenomena; Skin; Solitary Nucleus; Somatostatin; Stilbamidines; Substance P; Visceral Afferents | 2004 |
Pro-nociceptive role of peripheral galanin in inflammatory pain.
Topics: Action Potentials; Animals; Axons; Behavior, Animal; Capsaicin; Cell Count; Dose-Response Relationship, Drug; Drug Interactions; Galanin; Immunohistochemistry; In Vitro Techniques; Inflammation; Male; Microscopy, Electron; Pain; Pain Measurement; Peptide Fragments; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Receptor, Galanin, Type 2; Receptors, Drug; Skin; Substance P | 2004 |
Antinociceptive mechanism of L-DOPA.
Topics: Animals; Behavior, Animal; Benserazide; Benzazepines; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Injections, Spinal; Levodopa; Male; Mice; Pain; Pain Measurement; Spinal Cord; Substance P; Time Factors | 2004 |
Antinociceptive effects of galanin in the rat tuberomammillary nucleus and the plasticity of galanin receptor 1 during hyperalgesia.
Topics: Analysis of Variance; Animals; Carrageenan; Dose-Response Relationship, Drug; Functional Laterality; Galanin; Hyperalgesia; Hypothalamic Area, Lateral; Immunohistochemistry; Male; Neuronal Plasticity; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Reaction Time; Receptors, Galanin; Sciatic Neuropathy; Substance P; Time Factors | 2004 |
The contribution of autophosphorylated alpha-calcium-calmodulin kinase II to injury-induced persistent pain.
Topics: Animals; Behavior, Animal; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Count; Edema; Freund's Adjuvant; Ganglia, Spinal; Glycoproteins; Immunohistochemistry; Intermediate Filament Proteins; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nerve Tissue Proteins; Nociceptors; Oncogene Proteins v-fos; Pain; Pain Measurement; Pain Threshold; Peripherins; Phosphorylation; Physical Stimulation; Protein Kinase C; Reaction Time; Substance P; Time Factors; Trigeminal Ganglion; Wounds and Injuries | 2004 |
Vanilloid receptor VR1-positive primary afferents are glutamatergic and contact spinal neurons that co-express neurokinin receptor NK1 and glutamate receptors.
Topics: Afferent Pathways; Animals; Capsaicin; Fluorescent Antibody Technique; Glutamic Acid; Immunohistochemistry; Male; Membrane Transport Proteins; Microscopy, Electron, Transmission; Nociceptors; Pain; Posterior Horn Cells; Presynaptic Terminals; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Nerve Roots; Substance P; Synaptic Transmission; Vesicular Glutamate Transport Protein 2 | 2004 |
[Effect of tianyuan ketong recipe on the pain behavior, c-fos expression and P substance contents in dorsal horn of spinal cord in formalin induced pain model rats].
Topics: Analgesics, Non-Narcotic; Animals; Drugs, Chinese Herbal; Female; Formaldehyde; Immunohistochemistry; Male; Oncogene Proteins v-fos; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2004 |
Radiation-induced alteration of pain-related signals in an animal model with bone invasion from cancer.
Topics: Animals; Bone Neoplasms; Calcitonin Gene-Related Peptide; Carcinoma, Hepatocellular; Liver Neoplasms; Mice; Pain; Signal Transduction; Spinal Cord; Substance P | 2004 |
Neurokininergic mechanism within the lateral crescent nucleus of the parabrachial complex participates in the heart-rate response to nociception.
Topics: Afferent Pathways; Animals; Brachial Plexus; Decerebrate State; Efferent Pathways; Female; GABA Agonists; GABA-A Receptor Agonists; Heart Rate; Hypertension; Isonicotinic Acids; Male; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Piperidines; Pons; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Reflex; Spinal Cord; Substance P; Sympathetic Nervous System; Tachycardia | 2005 |
Change of dorsal horn neurochemistry in a mouse model of neuropathic cancer pain.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Male; Mice; Mice, Inbred BALB C; Neoplasms; Pain; Peripheral Nervous System Diseases; Posterior Horn Cells; Substance P | 2005 |
Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization.
Topics: Animals; Down-Regulation; Hyperalgesia; Injections, Spinal; Male; Microglia; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinase 14; Oligoribonucleotides, Antisense; Pain; Pain Measurement; Posterior Horn Cells; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2005 |
Postnatal changes in the spatial distributions of substance P and neurokinin-1 receptor in the trigeminal subnucleus caudalis of mice.
Topics: Aging; Animals; Animals, Newborn; Cell Differentiation; Immunohistochemistry; Mice; Mice, Inbred C57BL; Nociceptors; Pain; Presynaptic Terminals; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Trigeminal Caudal Nucleus | 2005 |
Nociceptive transmitter release in the dorsal spinal cord by capsaicin-sensitive fibers after noxious gastric stimulation.
Topics: Amino Acid Transport System X-AG; Animals; Autonomic Denervation; Calcitonin Gene-Related Peptide; Capsaicin; Female; Ganglia, Spinal; Gastric Mucosa; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Immunohistochemistry; Ion Channels; Neurons, Afferent; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Symporters; Thoracic Vertebrae; TRPV Cation Channels; Visceral Afferents | 2005 |
Alteration of cancer pain-related signals by radiation: proteomic analysis in an animal model with cancer bone invasion.
Topics: Analgesia; Animals; Blotting, Western; Bone Neoplasms; Calcitonin Gene-Related Peptide; Electrophoresis, Gel, Two-Dimensional; Male; Mass Spectrometry; Mice; Mice, Inbred C3H; Models, Animal; Neoplasm Proteins; Pain; Pain Measurement; Proteomics; Spinal Cord; Substance P | 2005 |
Mapping of tachykinins in the cat spinal cord.
Topics: Animals; Antibody Specificity; Brain Mapping; Cats; Cell Shape; Immunohistochemistry; Male; Neurokinin A; Neurokinin B; Neurons; Nociceptors; Pain; Posterior Horn Cells; Presynaptic Terminals; Species Specificity; Spinal Cord; Substance P; Synaptic Transmission; Tachykinins | 2005 |
Effects of the novel TRPV1 receptor antagonist SB366791 in vitro and in vivo in the rat.
Topics: Analgesics; Anilides; Animals; Capsaicin; Cells, Cultured; Cinnamates; Dose-Response Relationship, Drug; Drug Interactions; Hypothermia; Ion Channels; Male; Mice; Mice, Inbred BALB C; Neurons, Afferent; Nociceptors; Pain; Peripheral Nervous System; Rats; Rats, Wistar; Sensory Receptor Cells; Substance P; Trigeminal Ganglion; TRPV Cation Channels | 2005 |
Involvement of phosphorylated extracellular signal-regulated kinase in the mouse substance P pain model.
Topics: Animals; Brain; Dentate Gyrus; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Immunohistochemistry; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase 3; Pain; Pain Measurement; Paraventricular Hypothalamic Nucleus; Phosphorylation; Posterior Horn Cells; Spinal Cord; Substance P | 2005 |
Substance P inhibits progesterone conversion to neuroactive metabolites in spinal sensory circuit: a potential component of nociception.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Male; Models, Neurological; Neurons, Afferent; Nociceptors; Pain; Progesterone; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2005 |
Substance P-driven feed-forward inhibitory activity in the mammalian spinal cord.
Topics: Animals; Behavior, Animal; Feedback, Physiological; Glutamates; Mammals; Mice; Neural Inhibition; Pain; Physical Stimulation; Rats; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2005 |
Involvement of an increased spinal TRPV1 sensitization through its up-regulation in mechanical allodynia of CCI rats.
Topics: Animals; Blotting, Western; Calcitonin Gene-Related Peptide; Capsaicin; In Vitro Techniques; Injections, Spinal; Male; Nerve Tissue Proteins; Neuropeptides; Pain; Pain Measurement; Physical Stimulation; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Substance P; TRPV Cation Channels; Up-Regulation | 2005 |
Functional role of prostacyclin receptor in rat dorsal root ganglion neurons.
Topics: Animals; Animals, Newborn; Capsaicin; Cells, Cultured; Cyclic AMP; Cystitis, Interstitial; Disease Models, Animal; Female; Ganglia, Spinal; Iloprost; Inflammation Mediators; Membrane Potentials; Neurons, Afferent; Nociceptors; Pain; Potassium Chloride; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptors, Epoprostenol; Substance P; Vasodilator Agents | 2005 |
Postnatal development of ectopic sensory fibers containing endomorphin-2 in the white matter of the spinal cord of a transgenic mouse expressing nerve growth factor in oligodendrocytes.
Topics: Animals; Animals, Newborn; Female; Immunohistochemistry; Male; Mice; Mice, Transgenic; Microscopy, Confocal; Nerve Growth Factor; Neurons, Afferent; Oligodendroglia; Oligopeptides; Pain; Receptors, Opioid, mu; Spinal Cord; Substance P | 2005 |
Morphological evidence for GABA/glycine-cocontaining terminals in synaptic contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat.
Topics: Animals; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glycine; Male; Microscopy, Electron, Transmission; Neurons, Afferent; Nociceptors; Pain; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, Neurokinin-1; Sacrum; Spinal Cord; Substance P; Synaptic Membranes; Synaptic Transmission; Visceral Afferents | 2005 |
Changes of the neuropeptides content and gene expression in spinal cord and dorsal root ganglion after noxious colorectal distension.
Topics: Animals; Calcitonin Gene-Related Peptide; Colon; Dilatation, Pathologic; Galanin; Ganglia, Spinal; Humans; Male; Neuropeptides; Pain; Protein Precursors; Rats; Rats, Sprague-Dawley; Rectum; Reflex; RNA, Messenger; Spinal Cord; Substance P; Tachykinins; Vasoactive Intestinal Peptide; Visceral Afferents | 2005 |
Molecular and behavioral changes in nociception in a novel rat model of chronic pancreatitis for the study of pain.
Topics: Amylases; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Radiation; Electric Stimulation; Enzyme-Linked Immunosorbent Assay; Ganglia, Spinal; Gene Expression Regulation; Immunohistochemistry; Male; Nerve Growth Factor; Nociceptors; Pain; Pain Measurement; Pancreatitis; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Time Factors; Trinitrobenzenesulfonic Acid | 2005 |
A neuropeptide courier for delta-opioid receptors?
Topics: Animals; Carrier Proteins; Ganglia, Spinal; Humans; Mice; Neurons, Afferent; Pain; Protein Precursors; Protein Structure, Tertiary; Protein Transport; Receptors, Opioid, delta; Secretory Vesicles; Substance P; Tachykinins | 2005 |
Interaction with vesicle luminal protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia.
Topics: Afferent Pathways; Analgesics, Opioid; Animals; Cell Membrane; Cells, Cultured; Ganglia, Spinal; Gene Deletion; Male; Mice; Mice, Knockout; Microscopy, Electron, Transmission; Neurons, Afferent; Nociceptors; Pain; PC12 Cells; Protein Precursors; Protein Structure, Tertiary; Rats; Receptor Aggregation; Receptors, Cell Surface; Receptors, Opioid, delta; Secretory Vesicles; Substance P; Synaptic Transmission; Tachykinins | 2005 |
Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin.
Topics: Action Potentials; Amines; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Cell Count; Cell Death; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Functional Laterality; Gabapentin; gamma-Aminobutyric Acid; Gene Expression Regulation; Hot Temperature; Immunohistochemistry; Male; Neurons; Ondansetron; Pain; Pain Measurement; Pain Threshold; Pokeweed Mitogens; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Serotonin; Serotonin Antagonists; Spinal Cord; Substance P; Time Factors | 2005 |
CD26 modulates nociception in mice via its dipeptidyl-peptidase IV activity.
Topics: Analysis of Variance; Androstanes; Animals; Benzimidazoles; Dipeptidyl Peptidase 4; Dose-Response Relationship, Drug; Female; Lymphocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligopeptides; Pain; Pain Measurement; Reaction Time; Substance P | 2006 |
Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Behavior, Animal; Capsaicin; Excitatory Amino Acid Antagonists; Female; Formaldehyde; Histamine; Histidine Decarboxylase; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Histamine H1; Receptors, Neurokinin-1; Substance P; Time Factors | 2005 |
Differential inhibitory effects of mu-opioids on substance P- and capsaicin-induced nociceptive behavior in mice.
Topics: Analgesics, Opioid; Animals; Capsaicin; Male; Mice; Narcotics; Pain; Pain Measurement; Receptors, Opioid, mu; Substance P | 2006 |
Effect of intrathecal administration of hemokinin-1 on the withdrawal response to noxious thermal stimulation of the rat hind paw.
Topics: Animals; Behavior, Animal; Drug Interactions; Hindlimb; Hot Temperature; Male; Pain; Pain Measurement; Peptide Fragments; Quinuclidines; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P; Tachykinins; Time Factors | 2006 |
Remodelling of spinal nociceptive mechanisms in an animal model of monoarthritis.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ankle; Arthritis; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Agonists; Freund's Adjuvant; Functional Laterality; Immunohistochemistry; Iontophoresis; Male; Microscopy, Immunoelectron; N-Methylaspartate; Neuronal Plasticity; Neurons; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P; Time Factors | 2005 |
Involvement of dorsal column nucleus neurons in nociceptive transmission in aged rats.
Topics: Action Potentials; Age Factors; Aging; Animals; Brain Mapping; Dose-Response Relationship, Radiation; Electric Stimulation; Evoked Potentials; Immunohistochemistry; Neurons; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Inbred F344; Reaction Time; Spinal Cord; Substance P; Thalamic Nuclei; Time Factors | 2005 |
Stellate ganglion block inhibits formalin-induced nociceptive responses: mechanism of action.
Topics: Analgesia; Anesthetics, Local; Animals; Autonomic Nerve Block; Behavior, Animal; Bupivacaine; Formaldehyde; Male; Norepinephrine; Pain; Pain Management; Pain Measurement; Proto-Oncogene Proteins c-fos; Rabbits; Spinal Cord; Stellate Ganglion; Substance P | 2005 |
Transient receptor potential vanilloid 1, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis.
Topics: Animals; Arginine; Calcitonin Gene-Related Peptide; Capsaicin; Male; Neurons, Afferent; Pain; Pain Measurement; Pancreas; Pancreatitis; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Spinal Cord; Spinal Nerves; Substance P; TRPV Cation Channels | 2006 |
NSAID zaltoprofen possesses novel anti-nociceptive mechanism through blockage of B2-type bradykinin receptor in nerve endings.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Bradykinin B2 Receptor Antagonists; Male; Mice; Nerve Endings; Pain; Pain Measurement; Propionates; Receptor, Bradykinin B2; Sciatic Nerve; Substance P | 2006 |
Localization of SP- and CGRP-immunopositive nerve fibers in the hip joint of patients with painful osteoarthritis and of patients with painless failed total hip arthroplasties.
Topics: Aged; Arthroplasty, Replacement, Hip; Calcitonin Gene-Related Peptide; Female; Hip Joint; Humans; Immunohistochemistry; Middle Aged; Neuropeptides; Nociceptors; Osteoarthritis, Hip; Pain; Pain, Intractable; Postoperative Complications; Sensory Receptor Cells; Substance P; Synovial Membrane; Up-Regulation | 2007 |
Genetic manipulation of intraspinal plasticity after spinal cord injury alters the severity of autonomic dysreflexia.
Topics: Adenoviridae; Afferent Pathways; Animals; Autonomic Dysreflexia; Autonomic Fibers, Preganglionic; Axons; Bradycardia; Calcitonin Gene-Related Peptide; Colon; Cordotomy; Dilatation, Pathologic; Disease Models, Animal; Female; Genetic Therapy; Genetic Vectors; Hypertension; Microinjections; Nerve Growth Factor; Neuronal Plasticity; Pain; Posterior Horn Cells; Rats; Rats, Wistar; Recombinant Fusion Proteins; Rectum; Semaphorin-3A; Spinal Cord Injuries; Substance P; Vasoconstriction | 2006 |
Potent analgesic effects of a putative sodium channel blocker M58373 on formalin-induced and neuropathic pain in rats.
Topics: Analgesics; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Formaldehyde; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Male; Mexiletine; Motor Activity; Neuralgia; Nitriles; Pain; Pain Measurement; Piperidines; Rats; Rats, Wistar; Sodium Channel Blockers; Stress, Mechanical; Substance P; Veratridine | 2006 |
Pain discomfort and crevicular fluid changes induced by orthodontic elastic separators in children.
Topics: Adolescent; Case-Control Studies; Child; Dinoprostone; Female; Gingival Crevicular Fluid; Humans; Interleukin-1; Male; Orthodontic Appliances; Pain; Pain Measurement; Substance P; Tooth Movement Techniques | 2006 |
Characterization of three different sensory fibers by use of neonatal capsaicin treatment, spinal antagonism and a novel electrical stimulation-induced paw flexion test.
Topics: Animals; Animals, Newborn; Capsaicin; Disease Models, Animal; Electric Stimulation; Foot; Hindlimb; Male; Mice; Nerve Fibers, Unmyelinated; Neurokinin-1 Receptor Antagonists; Neuronal Plasticity; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Pain Threshold; Peripheral Nerve Injuries; Peripheral Nerves; Predictive Value of Tests; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Reflex; Spinal Nerve Roots; Substance P; Synaptic Transmission | 2006 |
Substance P release evoked by capsaicin or potassium from rat cultured dorsal root ganglion neurons is conversely modulated with bradykinin.
Topics: Animals; Boron Compounds; Bradykinin; Capsaicin; Cells, Cultured; Cyclooxygenase 2; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Inositol 1,4,5-Trisphosphate; MAP Kinase Kinase 1; MAP Kinase Signaling System; Neurons; Pain; Potassium; Potassium Chloride; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Receptor, Bradykinin B2; Signal Transduction; Substance P; Type C Phospholipases | 2006 |
Neuroanatomical evidence for segregation of nerve fibers conveying light touch and pain sensation in Eimer's organ of the mole.
Topics: Afferent Pathways; Animals; Carbocyanines; Fluorescent Dyes; Immunohistochemistry; Merkel Cells; Moles; Nerve Endings; Nerve Fibers; Neurofilament Proteins; Pain; Pyridinium Compounds; Quaternary Ammonium Compounds; Substance P; Touch | 2006 |
Both Ca2+-permeable and -impermeable AMPA receptors contribute to primary synaptic drive onto rat dorsal horn neurons.
Topics: Animals; Benzodiazepines; Calcium; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fluorescent Dyes; In Vitro Techniques; Pain; Patch-Clamp Techniques; Permeability; Posterior Horn Cells; Rats; Receptors, AMPA; Rhodamines; Staining and Labeling; Substance P; Synapses; Synaptic Transmission; TRPV Cation Channels | 2006 |
Familial limb pain in childhood: unusual manifestation of migraine?
Topics: Analgesics; Calcitonin Gene-Related Peptide; Child; Child, Preschool; Extremities; Family Health; Humans; Immunoenzyme Techniques; Male; Migraine Disorders; Pain; Substance P | 2006 |
Bradykinin is a potent pruritogen in atopic dermatitis: a switch from pain to itch.
Topics: Adult; Bradykinin; Cross-Over Studies; Dermatitis, Atopic; Female; Histamine; Histamine H1 Antagonists; Humans; Iontophoresis; Male; Pain; Pruritus; Serotonin; Single-Blind Method; Substance P; Urticaria; Water | 2006 |
Alteration in sensitivity of ionotropic glutamate receptors and tachykinin receptors in spinal cord contribute to development and maintenance of nerve injury-evoked neuropathic pain.
Topics: Alanine; Analgesics; Animals; Behavior, Animal; Benzamides; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Indoles; Isoindoles; Male; N-Methylaspartate; Pain; Pain Measurement; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Tachykinin; Sciatic Nerve; Spinal Cord; Substance P; Valine | 2006 |
Local and descending circuits regulate long-term potentiation and zif268 expression in spinal neurons.
Topics: Animals; Chronic Disease; Early Growth Response Protein 1; Efferent Pathways; Hot Temperature; Hyperalgesia; Long-Term Potentiation; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Nociceptors; Oligonucleotides, Antisense; Pain; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Antagonists; Substance P; Synaptic Transmission | 2006 |
Visceral pain perception is determined by the duration of colitis and associated neuropeptide expression in the mouse.
Topics: Acute Disease; Animals; beta-Endorphin; CD4-Positive T-Lymphocytes; Chronic Disease; Colitis; Colon; Compliance; Interleukin-1beta; Male; Mice; Mice, Inbred BALB C; Neuropeptides; Pain; Pain Threshold; Physical Stimulation; Receptors, Opioid, mu; Substance P | 2007 |
[Effect of nociceptin on histamine and serotonin release in the central nervous system].
Topics: Animals; Disease Models, Animal; Hippocampus; Histamine; Histamine Release; Hypothalamus; Pain; Rats; Rats, Wistar; Serotonin; Substance P | 2006 |
Primary afferent NMDA receptors increase dorsal horn excitation and mediate opiate tolerance in neonatal rats.
Topics: Afferent Pathways; Aging; Analgesics, Opioid; Animals; Animals, Newborn; Cell Differentiation; Drug Tolerance; Excitatory Postsynaptic Potentials; Ganglia, Spinal; Microscopy, Immunoelectron; Neurons, Afferent; Nociceptors; Pain; Patch-Clamp Techniques; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Nerve Roots; Substance P; Synaptic Transmission | 2006 |
Changes in pain behavior induced by formalin, substance P, glutamate and pro-inflammatory cytokines in immobilization-induced stress mouse model.
Topics: Analgesia; Animals; Behavior, Animal; Cytokines; Disease Models, Animal; Glutamic Acid; Inflammation Mediators; Male; Mice; Mice, Inbred ICR; Nociceptors; Pain; Pain Measurement; Pain Threshold; Restraint, Physical; Stress, Psychological; Substance P | 2006 |
Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways.
Topics: Afferent Pathways; Animals; Drug Tolerance; Dynorphins; Hyperalgesia; Male; Morphine; Neurons; Ondansetron; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Cord; Substance P | 2007 |
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium Signaling; Cell Line; Cells, Cultured; Epithelial Cells; Ganglia, Spinal; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nociceptors; Pain; Peptides; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; Substance P; TRPV Cation Channels | 2007 |
S-(+)-fenfluramine-induced nociceptive behavior in mice: Involvement of interactions between spinal serotonin and substance P systems.
Topics: Animals; Fenfluramine; Male; Mice; Morphine; Pain; Serotonin; Serotonin Agents; Spinal Cord; Substance P | 2007 |
Prognostic factors in arthrocentesis of the temporomandibular joint: Comparison of bradykinin, leukotriene B4, prostaglandin E2, and substance P level in synovial fluid between successful and unsuccessful cases.
Topics: Adolescent; Adult; Aged; Bradykinin; Dinoprostone; Female; Humans; Joint Dislocations; Leukotriene B4; Male; Middle Aged; Osteoarthritis; Pain; Paracentesis; Prognosis; Statistics, Nonparametric; Substance P; Synovial Fluid; Temporomandibular Joint Disorders | 2007 |
Contribution of substance P and neurokinin A to the differential injury-induced thermal and mechanical responsiveness of lamina I and V neurons.
Topics: Animals; Female; Hot Temperature; Male; Mice; Mice, Knockout; Neurokinin A; Pain; Pain Measurement; Physical Stimulation; Posterior Horn Cells; Spinal Cord Injuries; Substance P | 2007 |
Sensory neuron and substance P involvement in symptoms of a zymosan-induced rat model of acute bowel inflammation.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Colitis; Colon; Disease Models, Animal; Enteric Nervous System; Ethanol; Inflammation Mediators; Male; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Oligonucleotides, Antisense; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Sympathetic Nervous System; Zymosan | 2007 |
Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic constriction injury and spinal nerve ligation models.
Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Constriction, Pathologic; Denervation; Disease Models, Animal; Electric Stimulation; Hyperesthesia; Ligation; Male; Medulla Oblongata; Nerve Fibers, Myelinated; Neurons, Afferent; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Sciatic Nerve; Sensory Thresholds; Spinal Cord; Spinal Cord Injuries; Spinal Nerves; Substance P; Time Factors; Up-Regulation | 2007 |
Behavioral and immunohistological assessment of painful neuropathy induced by a single oxaliplatin injection in the rat.
Topics: Analgesics, Non-Narcotic; Animals; Antineoplastic Agents; Behavior, Animal; Calcitonin Gene-Related Peptide; Carbamazepine; Hyperalgesia; Immunohistochemistry; Magnesium; Male; Neurons, Afferent; Organoplatinum Compounds; Oxaliplatin; Pain; Pain Measurement; Peripheral Nervous System Diseases; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Substance P | 2007 |
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site.
Topics: 2-Amino-5-phosphonovalerate; Agmatine; Animals; Cycloserine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Injections, Spinal; Ion Channels; Kynurenic Acid; Mice; Morphine; Neurokinin A; Nociceptors; Pain; Peptide Fragments; Piperidines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Tachykinin; Substance P | 2007 |
Antinociceptive action of myricitrin: involvement of the K+ and Ca2+ channels.
Topics: Acetic Acid; Analgesics; Animals; Calcium Channels; Calcium Radioisotopes; Calcium Signaling; Capsaicin; Female; Flavonoids; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gi-Go; Injections, Intraventricular; Injections, Spinal; Interleukin-1beta; Ion Channel Gating; Male; Mice; Pain; Pain Measurement; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Substance P; Tumor Necrosis Factor-alpha | 2007 |
Colocalization and shared distribution of endomorphins with substance P, calcitonin gene-related peptide, gamma-aminobutyric acid, and the mu opioid receptor.
Topics: Animals; Brain; Calcitonin Gene-Related Peptide; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Neurons; Oligopeptides; Opioid Peptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord; Substance P; Tissue Distribution | 2007 |
Activation of spinal cholecystokinin and neurokinin-1 receptors is associated with the attenuation of intrathecal morphine analgesia following electroacupuncture stimulation in rats.
Topics: Acupuncture Points; Analgesia; Analgesics, Opioid; Animals; Cholecystokinin; Dose-Response Relationship, Drug; Electroacupuncture; Gene Expression; Hindlimb; Injections, Spinal; Male; Morphine; Pain; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Receptors, Neurokinin-1; RNA, Messenger; Spinal Cord; Substance P | 2007 |
The intracerebroventricular kainic acid-induced damage affects animal nociceptive behavior.
Topics: Animals; Behavior, Animal; Cytokines; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Kainic Acid; Male; Mice; Neurons; Pain; Pain Measurement; Substance P | 2007 |
Spinal mechanisms of antinociceptive action caused by diphenyl diselenide.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzene Derivatives; Bradykinin; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Inhibitory Concentration 50; Interleukin-1beta; Male; Mice; Organoselenium Compounds; Pain; Pain Measurement; Spinal Cord; Substance P; Tumor Necrosis Factor-alpha | 2007 |
Leucine at the carboxyl-terminal of endokinins C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hexokinase; Hyperalgesia; Leucine; Male; Pain; Pain Measurement; Peptides; Physical Stimulation; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reaction Time; Spinal Cord; Substance P; Tachykinins | 2007 |
Intrathecal substance P (1-7) prevents morphine-evoked spontaneous pain behavior via spinal NMDA-NO cascade.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Glutamic Acid; Male; Morphine; N-Methylaspartate; Nitrates; Nitric Oxide; Nitrites; Pain; Peptide Fragments; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Time Factors | 2007 |
Synaptobrevin I mediates exocytosis of CGRP from sensory neurons and inhibition by botulinum toxins reflects their anti-nociceptive potential.
Topics: Animals; Botulinum Toxins; Bradykinin; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Exocytosis; Membrane Potentials; Mice; Neurons, Afferent; Nociceptors; Pain; Potassium; Protein Isoforms; R-SNARE Proteins; Rats; SNARE Proteins; Substance P; Synaptic Vesicles; Synaptosomal-Associated Protein 25; Syntaxin 1; Trigeminal Ganglion | 2007 |
Neurokinin receptors modulate the impact of uncontrollable stimulation on adaptive spinal plasticity.
Topics: Adaptation, Psychological; Animals; Electroshock; Female; Learning; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuronal Plasticity; Pain; Peptide Fragments; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Spinal Cord; Spinal Cord Injuries; Substance P; Vocalization, Animal | 2007 |
Interactions of galanin with endomorphin-2, vasopressin and oxytocin in nociceptive modulation of the trigemino-hypoglossal reflex in rats.
Topics: Animals; Arginine Vasopressin; Cerebral Ventricles; Dental Pulp; Electric Stimulation; Galanin; Hypoglossal Nerve; Male; Narcotic Antagonists; Oligopeptides; Oxytocin; Pain; Pain Measurement; Perfusion; Rats; Rats, Long-Evans; Reflex; Substance P; Tongue; Trigeminal Nerve | 2008 |
Decreased substance P and NK1 receptor immunoreactivity and function in the spinal cord dorsal horn of morphine-treated neonatal rats.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Down-Regulation; Drug Tolerance; Ganglia, Spinal; Immunohistochemistry; Morphine; Nociceptors; Organ Culture Techniques; Pain; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Messenger; Substance P | 2008 |
Dorsal horn NK1-expressing neurons control windup of downstream trigeminal nociceptive neurons.
Topics: Afferent Pathways; Animals; Male; Nerve Fibers, Unmyelinated; Neural Pathways; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Nociceptors; Pain; Piperidines; Posterior Horn Cells; Presynaptic Terminals; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Trigeminal Caudal Nucleus; Trigeminal Nerve; Trigeminal Nuclei | 2008 |
The role of hypoxia and substance P in the painful crisis of homozygous sickle cell disease.
Topics: Anemia, Sickle Cell; Hematocrit; Homozygote; Humans; Hypoxia; Models, Biological; Models, Theoretical; Oxygen; Pain; Substance P | 2008 |
The differential effects of emotional or physical stress on pain behaviors or on c-Fos immunoreactivity in paraventricular nucleus or arcuate nucleus.
Topics: Analysis of Variance; Animals; Arcuate Nucleus of Hypothalamus; Chronic Disease; Disease Models, Animal; Glutamic Acid; Immunohistochemistry; Injections, Spinal; Interferon-gamma; Interleukin-1beta; Male; Mice; Mice, Inbred ICR; Pain; Pain Threshold; Paraventricular Hypothalamic Nucleus; Proto-Oncogene Proteins c-fos; Statistics, Nonparametric; Stress, Psychological; Substance P; Tumor Necrosis Factor-alpha | 2008 |
Role of calcitonin gene-related peptide and substance P in different models of pain.
Topics: Animals; Calcitonin Gene-Related Peptide; Central Nervous System; Formaldehyde; Hyperalgesia; Immunohistochemistry; Injections, Intraperitoneal; Injections, Subcutaneous; Lumbosacral Region; Male; Nitroglycerin; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Substance P; Trigeminal Caudal Nucleus | 2008 |
Spinal N-methyl-D-aspartate receptors and nociception-evoked release of primary afferent substance P.
Topics: Animals; Calcitonin Gene-Related Peptide; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Image Processing, Computer-Assisted; Male; Microscopy, Confocal; N-Methylaspartate; Neurons, Afferent; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Substance P | 2008 |
Elevated plasma substance P in sickle cell disease and vaso-occlusive crisis.
Topics: Anemia, Sickle Cell; Antiemetics; Aprepitant; Clinical Trials, Phase I as Topic; Humans; Models, Immunological; Morpholines; Neurokinin-1 Receptor Antagonists; Pain; Substance P | 2008 |
The differential effect of morphine and beta-endorphin administered intracerebroventricularly on pERK and pCaMK-II expression induced by various nociceptive stimuli in mice brains.
Topics: Analgesics, Opioid; Animals; beta-Endorphin; Blotting, Western; Brain Chemistry; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Extracellular Signal-Regulated MAP Kinases; Formaldehyde; Immunohistochemistry; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Pain; Paraventricular Hypothalamic Nucleus; Substance P | 2008 |
Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons.
Topics: Aging; Animals; Animals, Newborn; Cholecystokinin; Embryo, Mammalian; Gene Expression Regulation; Homeodomain Proteins; Mice; Mice, Transgenic; Mutation; Neurokinin B; Neurons; Neuropeptides; Pain; PAX2 Transcription Factor; Somatostatin; Spinal Cord; Substance P; Transcription Factor Brn-3A; Transcription, Genetic | 2008 |
Differential activation of spinal cord glial cells in murine models of neuropathic and cancer pain.
Topics: Animals; Behavior, Animal; Bone Neoplasms; Cell Line; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Mice; Mice, Inbred C3H; Neoplasms; Neuroglia; Pain; Pain Measurement; Peripheral Nervous System Diseases; Peripheral Nervous System Neoplasms; Physical Stimulation; Spinal Cord; Substance P; Tomography, X-Ray Computed | 2009 |
Substance p analogue blocks sp-induced facilitation of a spinal nociceptive reflex.
Topics: Animals; Injections, Spinal; Male; Pain; Rats; Rats, Inbred Strains; Reflex; Spinal Cord; Substance P | 1984 |
The postnatal physiological and neurochemical development of peripheral sensory C fibres.
Topics: Acid Phosphatase; Animals; Animals, Newborn; Female; Male; Nerve Fibers; Neural Conduction; Nociceptors; Pain; Peripheral Nerves; Rats; Reflex; Substance P | 1984 |
Experimental pain and neuropeptides.
Topics: Animals; Enkephalin, Methionine; Male; Morphine; Pain; Rabbits; Rats; Rats, Inbred Strains; Reticular Formation; Spinal Cord; Substance P | 1984 |
GABAergic mechanisms in antinociception.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Analgesics; Animals; Baclofen; Bicuculline; Central Nervous System; gamma-Aminobutyric Acid; Isoxazoles; Mice; Muscimol; Pain; Rats; Stereoisomerism; Substance P; Synaptic Transmission; Vigabatrin | 1984 |
The mechanisms of pain and opioid-induced analgesia.
Topics: Afferent Pathways; Analgesics, Opioid; Animals; Brain; Endorphins; Humans; Nociceptors; Pain; Receptors, Opioid; Serotonin; Spinal Cord; Substance P; Synaptic Transmission | 1984 |
Effect of neuroactive peptides on labeled 5-hydroxytryptamine release from rat spinal cord.
Topics: Animals; Baclofen; beta-Endorphin; Endorphins; Enkephalin, Methionine; Male; Naloxone; Neuropeptides; Neurotensin; Pain; Rats; Rats, Inbred Strains; Secretory Rate; Serotonin; Somatostatin; Spinal Cord; Substance P | 1984 |
Pain.
Topics: Animals; Brain; Endorphins; Enkephalins; Humans; Pain; Substance P | 1980 |
Substance P: does it produce analgesia or hyperalgesia?
Topics: Acetates; Animals; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Hyperesthesia; Mice; Nociceptors; Pain; Perception; Receptors, Drug; Substance P | 1980 |
[Pain mechanisms--historical background and current topics (author's transl)].
Topics: Analgesia; Animals; Brain; Brain Chemistry; Cats; Efferent Pathways; Endorphins; Ganglia, Spinal; Haplorhini; History, 17th Century; History, 19th Century; History, 20th Century; Humans; Morphine; Neurophysiology; Nociceptors; Pain; Peripheral Nerves; Rats; Somatostatin; Spinal Cord; Spinothalamic Tracts; Substance P; Thalamic Nuclei | 1980 |
Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo.
Topics: Afferent Pathways; Animals; Capsaicin; Cats; Injections, Spinal; Morphine; Nociceptors; Pain; Potassium; Rats; Spinal Cord; Substance P | 1980 |
Substance P, morphine and methionine-enkephalin: effects on spontaneous and evoked neuronal firing in the nucleus reticularis gigantocellularis of the rat.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Medulla Oblongata; Morphine; Neurotransmitter Agents; Pain; Pressure; Rats; Substance P | 1980 |
[A pharmacological study on the algesiogenic and analgesic activity of substance P].
Topics: Analgesics; Animals; Brain; Brain Chemistry; Endorphins; Humans; Mice; Nervous System; Pain; Rabbits; Rats; Substance P | 1980 |
Substance P suppresses stress-induced eating.
Topics: Animals; Eating; Pain; Rats; Starvation; Stress, Physiological; Substance P | 1980 |
[Substance P and pain: possible pathogenic role in chronic primary headache].
Topics: Chronic Disease; Headache; Humans; Pain; Substance P | 1980 |
Brain peptides (second of two parts).
Topics: Acupuncture Therapy; Animals; Body Temperature Regulation; Brain; Brain Diseases; Cerebrospinal Fluid; Cholecystokinin; Endorphins; Enkephalins; Epilepsy; Feeding Behavior; Humans; Learning; Memory; Nervous System Diseases; Neurotransmitter Agents; Pain; Peptides; Pituitary Hormones; Substance P; Synaptic Transmission | 1981 |
[Implication of endorphins and substance P in pain modulation (author's transl)].
Topics: Animals; Endorphins; Humans; Pain; Substance P | 1980 |
Neuropeptides and monoaminergic neurotransmitters: their relation to pain.
Topics: Analgesia; Angiotensin II; beta-Endorphin; Cholecystokinin; Endorphins; Enkephalins; Humans; Neurotensin; Neurotransmitter Agents; Pain; Peptides; Somatostatin; Substance P | 1980 |
[Substance P].
Topics: Animals; Autonomic Nervous System; Central Nervous System; Humans; Narcotics; Neural Pathways; Pain; Rats; Substance P | 1981 |
A re-evaluation of the neurochemical and antinociceptive effects of intrathecal capsaicin in the rat.
Topics: Animals; Capsaicin; Fatty Acids, Unsaturated; Glutamate Decarboxylase; Male; Pain; Rats; Somatostatin; Spinal Cord; Substance P | 1981 |
Vascular and sensory responses of human skin to mild injury after topical treatment with capsaicin.
Topics: Administration, Topical; Axons; Capsaicin; Differential Threshold; Fatty Acids, Unsaturated; Humans; Pain; Reflex; Sensation; Skin; Substance P; Vasodilation | 1981 |
Characterization in guinea pigs of the sensory effects of the putative substance P neurotoxin capsaicin.
Topics: Animals; Capsaicin; Fatty Acids, Unsaturated; Guinea Pigs; Male; Morphine; Pain; Sensory Receptor Cells; Somatostatin; Substance P | 1981 |
Intrathecal substance P depresses the tail-flick response - antagonism by naloxone.
Topics: Animals; Dose-Response Relationship, Drug; Female; Injections, Spinal; Naloxone; Pain; Rats; Rats, Inbred Strains; Reaction Time; Spinal Cord; Substance P | 1981 |
Algesiogenic and analgesic activities of synthetic substance P.
Topics: Analgesics; Animals; Bradykinin; Brain Chemistry; Dose-Response Relationship, Drug; Endorphins; Female; Histamine Release; Humans; Male; Mice; Pain; Rabbits; Rats; Rats, Inbred Strains; Substance P | 1981 |
Sensory and motor functions of spinal cord substance P.
Topics: Animals; Capsaicin; Mice; Motor Activity; Pain; Receptors, Cell Surface; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Skin; Spinal Cord; Substance P | 1981 |
Depletion of substance P-containing axons in substantia gelatinosa of patients with diminished pain sensitivity.
Topics: Antibodies, Monoclonal; Axons; Dysautonomia, Familial; Humans; Pain; Spinal Cord; Substance P; Substantia Gelatinosa; Substantia Nigra | 1982 |
[Effect of substance P and substance P fragments on the pain threshold in mice].
Topics: Animals; Mice; Morphine; Pain; Sensory Thresholds; Substance P | 1982 |
Transmitters involved in central processing of nociceptive information.
Topics: Animals; Enkephalins; gamma-Aminobutyric Acid; Glycine; Humans; Neural Inhibition; Neurons, Afferent; Neurotransmitter Agents; Norepinephrine; Pain; Serotonin; Spinal Cord; Spinal Nerve Roots; Substance P; Synaptic Transmission | 1982 |
Elevated cerebrospinal fluid substance P in arachnoiditis is reduced by systemic administration of morphine.
Topics: Arachnoiditis; Diabetic Neuropathies; Humans; Morphine; Pain; Substance P | 1982 |
Differential effects of D-Ala2 analogues of enkephalins on substance P-induced analgesia in rodents.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Pain; Rats; Rats, Inbred Strains; Substance P | 1982 |
Neurotransmitters and CNS disease. Pain.
Topics: Central Nervous System; Endorphins; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Neurons, Afferent; Neurotransmitter Agents; Nociceptors; Pain; Receptors, Cell Surface; Substance P | 1982 |
Capsaicin and nociception in the rat and mouse. Possible role of substance P.
Topics: Animals; Behavior, Animal; Capsaicin; Eye; Fatty Acids, Unsaturated; Female; Hindlimb; Injections, Spinal; Male; Mice; Nociceptors; Pain; Rats; Rats, Inbred Strains; Species Specificity; Substance P; Thermoreceptors | 1982 |
Substance P reduces tail-flick latency: implications for chronic pain syndromes.
Topics: Analgesia; Animals; Capsaicin; Dose-Response Relationship, Drug; Hot Temperature; Male; Pain; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Cell Surface; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1982 |
Correlation between substance P content of primary sensory neurones and pain sensitivity in rats exposed to antibodies to nerve growth factor.
Topics: Animals; Autoantibodies; Female; Ganglia, Spinal; Nerve Growth Factors; Neurons, Afferent; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Spinal Cord; Substance P | 1982 |
[Depressive effects of substance P on visceral pain in rats].
Topics: Analgesics; Animals; Male; Pain; Periaqueductal Gray; Rats; Receptors, Opioid; Sensory Thresholds; Substance P | 1982 |
Some rat sensory neurons in culture express characteristics of differentiated pain sensory cells.
Topics: Animals; Animals, Newborn; Bradykinin; Capsaicin; Cell Differentiation; Cells, Cultured; Dinoprostone; Ganglia, Spinal; Neurons; Pain; Prostaglandins E; Rats; Substance P; Trigeminal Nerve | 1983 |
Pharmacological studies on the application, disposition, and release of neurotensin in the spinal cord.
Topics: Animals; Capsaicin; Cats; Histocytochemistry; Kainic Acid; Neurotensin; Nociceptors; Pain; Radioimmunoassay; Reaction Time; Spinal Cord; Spinal Nerve Roots; Substance P; Tissue Distribution | 1982 |
The effects of centrally administered antisera to neurotensin and related peptides upon nociception and related behaviors.
Topics: Animals; Body Temperature Regulation; Electroshock; Hot Temperature; Immune Sera; Kinetics; Male; Motor Activity; Neurotensin; Nociceptors; Pain; Rats; Rats, Inbred Strains; Reaction Time; Substance P | 1982 |
Intrathecal serotonin in mice: analgesia and inhibition of a spinal action of substance P.
Topics: Analgesia; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Hot Temperature; Male; Mice; Nociceptors; Pain; Serotonin; Serotonin Antagonists; Substance P | 1983 |
Distribution of substance P-responsive and nociceptive neurones in relation to substance P-immunoreactivity within the caudal trigeminal nucleus of the rat.
Topics: Animals; Brain Mapping; Male; Neurotransmitter Agents; Nociceptors; Pain; Rats; Rats, Inbred Strains; Skin; Substance P; Trigeminal Caudal Nucleus; Trigeminal Nucleus, Spinal | 1983 |
Substance P and endogenous opioids: how and where they could play a role in cluster headache.
Topics: Adult; Cluster Headache; Endorphins; Humans; Male; Pain; Substance P; Time Factors; Vascular Headaches | 1983 |
Dental pain. 2. Neuropharmacology and biochemistry.
Topics: Endorphins; Enkephalins; Humans; Neurotransmitter Agents; Pain; Prostaglandins; Receptors, Opioid; Substance P; Toothache | 1983 |
Effects of morphine on noxious stimuli-induced release of substance P from rabbit dorsal horn in vivo.
Topics: Animals; Male; Methysergide; Morphine; Naloxone; Pain; Prazosin; Rabbits; Spinal Cord; Substance P | 1983 |
Pain perception and alleviation in animals.
Topics: Afferent Pathways; Analgesia; Analgesics; Animals; Animals, Laboratory; Behavior, Animal; Biological Evolution; Brain; Cats; Dogs; Electric Stimulation; Electrophysiology; Endorphins; Horses; Neurons; Nociceptors; Pain; Peptides; Perception; Spinal Cord; Stress, Physiological; Substance P; Surgical Procedures, Operative; Synapses | 1984 |
Current status and developments in substance P research (selected topics).
Topics: Animals; Catecholamines; Pain; Rats; Research; Sensory Thresholds; Stress, Physiological; Substance P | 1984 |
Respiratory effects of intrathecal capsaicin in arthritic and non-arthritic rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Body Weight; Capsaicin; Injections, Spinal; Male; Pain; Rats; Rats, Inbred Strains; Respiration; Substance P | 1984 |
Hyperalgesia produced by intrathecal substance P and related peptides: desensitization and cross desensitization.
Topics: Animals; Drug Tolerance; Eledoisin; Injections, Spinal; Male; Nociceptors; Pain; Peptides; Physalaemin; Rats; Rats, Inbred Strains; Reaction Time; Substance P; Time Factors | 1984 |
Spinal substance P transmits bradykinin but not osmotic stimuli from hepatic portal vein to hypothalamus in rat.
Topics: Animals; Bradykinin; Female; Hypothalamo-Hypophyseal System; Nociceptors; Pain; Portal Vein; Rats; Receptors, Cell Surface; Spinal Cord; Substance P; Synaptic Transmission; Water-Electrolyte Balance | 1984 |
Innervation of human bone periosteum by peptidergic nerves.
Topics: Fluorescence; Histocytochemistry; Humans; Immunologic Techniques; Nerve Fibers; Neurons; Pain; Periosteum; Substance P | 1984 |
Action of intrathecal capsaicin and its structural analogues on the content and release of spinal substance P: selectivity of action and relationship to analgesia.
Topics: Animals; Capsaicin; Cholecystokinin; Homovanillic Acid; Injections, Spinal; Male; Pain; Phenylacetates; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Tachyphylaxis; Vasoactive Intestinal Peptide | 1984 |
Peptides and nociception.
Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; Bombesin; Bradykinin; Cholecystokinin; Dynorphins; Endorphins; Enkephalins; Melanocyte-Stimulating Hormones; Mice; Nervous System; Neurotensin; Pain; Peptide Fragments; Peptides; Rats; Somatostatin; Substance P; Thyrotropin-Releasing Hormone; Vasopressins | 1984 |
[Pathophysiology of pain].
Topics: Bradykinin; Delta Sleep-Inducing Peptide; Dopamine; Endorphins; Humans; Models, Theoretical; Nociceptors; Oligopeptides; Pain; Prostaglandins; Serotonin; Stress, Psychological; Substance P | 1984 |
[Physiology and physiopathology of substance P].
Topics: Eye; Ganglia, Sympathetic; Humans; Neurons, Afferent; Neurotransmitter Agents; Pain; Respiratory System; Skin; Substance P; Synaptic Transmission; Synaptic Vesicles | 1984 |
Effects of cysteamine on pain behaviour and on somatostatin- and substance P-like immunoreactivity in the substantia gelatinosa of the rat.
Topics: Animals; Capsaicin; Cysteamine; Histocytochemistry; Hot Temperature; Male; Pain; Rats; Rats, Inbred Strains; Somatostatin; Spinal Cord; Substance P; Substantia Gelatinosa | 1984 |
Biphasic time-course of capsaicin-induced substance P depletion: failure to correlate with thermal analgesia in the rat.
Topics: Animals; Capsaicin; Hot Temperature; Male; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Spinal Cord; Substance P | 1984 |
Substance P in the trigeminal system at postmortem: evidence for a role in pain pathways in man.
Topics: Blood Vessels; Brain Stem; Humans; Meninges; Muscles; Pain; Skin; Substance P; Synaptic Transmission; Trigeminal Ganglion; Trigeminal Nerve | 1983 |
Innervation of recurrent aphthous ulcers.
Topics: Adult; Calcitonin Gene-Related Peptide; Chronic Disease; Female; Humans; Male; Middle Aged; Mouth Mucosa; Pain; Recurrence; Stomatitis, Aphthous; Substance P | 1994 |
[Met-enkephalin and substance P. Comparison of CSF levels in patients with chronic pain based on a sampling procedure].
Topics: Adult; Aged; Chronic Disease; Enkephalin, Methionine; Female; Humans; Male; Middle Aged; Pain; Sampling Studies; Spinal Puncture; Substance P; Ventriculoperitoneal Shunt | 1993 |
Time-dependent changes in Bolton-Hunter-labeled 125I-substance P binding in rat spinal cord following unilateral adjuvant-induced peripheral inflammation.
Topics: Animals; Arthritis, Experimental; Autoradiography; Edema; Inflammation; Iodine Radioisotopes; Kinetics; Male; Neurons, Afferent; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Succinimides; Synapses; Synaptic Transmission | 1993 |
Spinal co-administration of peptide substance P antagonist increases antinociceptive effect of the opioid peptide biphalin.
Topics: Analgesics; Animals; Drug Synergism; Enkephalins; Injections, Spinal; Male; Naltrexone; Pain; Pain Measurement; Rats; Rats, Wistar; Substance P | 1994 |
Changes of spinal substance P, calcitonin gene-related peptide, somatostatin, Met-enkephalin and neurotensin in rats in response to formalin-induced pain.
Topics: Animals; Calcitonin Gene-Related Peptide; Enkephalin, Methionine; Female; Formaldehyde; Image Processing, Computer-Assisted; Male; Microscopy, Electron; Neuropeptides; Neurotensin; Pain; Rats; Rats, Sprague-Dawley; Somatostatin; Spinal Cord; Substance P | 1994 |
Activity at phencyclidine and mu opioid sites mediates the hyperalgesic and antinociceptive properties of the N-terminus of substance P in a model of visceral pain.
Topics: Animals; Biological Assay; Disease Models, Animal; Dizocilpine Maleate; Hyperalgesia; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peptide Fragments; Phencyclidine; Receptors, Opioid, mu; Spinal Cord; Substance P | 1994 |
Evidence for localized release of substance P within rat spinal cord evoked by physiological and electrical stimuli.
Topics: Anesthesia, General; Animals; Electric Stimulation; Female; Functional Laterality; Hindlimb; Hot Temperature; Male; Pain; Physical Stimulation; Rats; Reference Values; Spinal Cord; Substance P | 1994 |
Substance P N-terminus inhibits C-fiber-dependent facilitation of the rat flexor reflex.
Topics: Animals; Female; Nerve Fibers; Pain; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reflex; Substance P | 1994 |
Experimental lumbar radiculopathy. Immunohistochemical and quantitative demonstrations of pain induced by lumbar nerve root irritation of the rat.
Topics: Animals; Calcitonin Gene-Related Peptide; Ganglia, Spinal; Genes, fos; Hot Temperature; Male; Nerve Compression Syndromes; Pain; Pain Threshold; Paralysis; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerve Roots; Substance P; Sutures; Vasoactive Intestinal Peptide | 1994 |
Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arginine; Dexamethasone; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Spinal; Isoquinolines; Male; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Pain Measurement; Pain Threshold; Piperazines; Protein Kinase C; Rats; Reflex; Substance P | 1994 |
The calcitonin gene-related peptide antagonist CGRP8-37 increases the latency to withdrawal responses in rats.
Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Foot; Hot Temperature; Injections, Spinal; Male; Pain; Peptide Fragments; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P | 1994 |
Prevaccination with diluted Freund adjuvant prevents the development of chronic pain and transient release of cerebrospinal fluid substance P in adjuvant-induced arthritis in rats.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Body Weight; Chronic Disease; Freund's Adjuvant; Hindlimb; Motor Activity; Pain; Pain Measurement; Rats; Substance P; Vaccination; Vocalization, Animal | 1994 |
Spinal antinociception by morphine in rats is antagonised by galanin receptor antagonists.
Topics: Animals; Binding Sites; Bradykinin; Galanin; Injections, Spinal; Male; Morphine; Pain; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Galanin; Receptors, Gastrointestinal Hormone; Spinal Cord; Substance P; Synaptic Membranes | 1994 |
Inhibitory effects of salmon calcitonin on the tail-biting and scratching behavior induced by substance P and three excitatory amino acids.
Topics: Afferent Pathways; Animals; Calcitonin; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Injections, Intraventricular; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Pain; Pain Measurement; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurokinin-1; Spinal Cord; Substance P; Tail | 1994 |
Noxious stimulation decreases substance P binding in rat spinal dorsal horn: competition by endogenous ligand?
Topics: Animals; Binding, Competitive; Hot Temperature; Ligands; Male; Pain; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Stimulation, Chemical; Substance P | 1994 |
The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration.
Topics: Animals; Formaldehyde; Ganglia, Spinal; Gene Expression Regulation; Male; Morphine; Naltrexone; Neurokinin B; Pain; Premedication; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-3; RNA, Messenger; Spinal Cord; Substance P; Time Factors | 1995 |
The non-peptide neurokinin-1 antagonist, RPR 100893, decreases c-fos expression in trigeminal nucleus caudalis following noxious chemical meningeal stimulation.
Topics: Animals; Blood Proteins; Capsaicin; Guinea Pigs; Indoles; Isoindoles; Male; Meninges; Neurokinin-1 Receptor Antagonists; Pain; Proto-Oncogene Proteins c-fos; Substance P; Trigeminal Nuclei | 1995 |
Scratching behavior induced by pruritogenic but not algesiogenic agents in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Formaldehyde; Histamine; Male; Mice; p-Methoxy-N-methylphenethylamine; Pain; Pruritus; Substance P | 1995 |
Noxious peripheral stimulation produces antinociception mediated via substance P and opioid mechanisms in the rat tail-flick test.
Topics: Animals; Capsaicin; Endorphins; Hindlimb; Hot Temperature; Immersion; Male; Naloxone; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Substance P | 1995 |
The neurokinin-1 receptor antagonist, sendide, exhibits antinociceptive activity in the formalin test.
Topics: Animals; Behavior, Animal; Formaldehyde; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Substance P | 1995 |
Spinal projections to the parabrachial nucleus are substance P-immunoreactive.
Topics: Afferent Pathways; Animals; Cats; Immunohistochemistry; Male; Nerve Endings; Pain; Pons; Spinal Cord; Substance P | 1995 |
Tiapride attenuates pain transmission through an indirect activation of central serotonergic mechanism.
Topics: Animals; Central Nervous System; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dopamine Antagonists; Female; Fenclonine; Indoles; Injections, Spinal; Ketanserin; Male; Mice; Nociceptors; Pain; Pain Measurement; Pindolol; Serotonin; Serotonin Antagonists; Somatostatin; Substance P; Synaptic Transmission; Tiapamil Hydrochloride; Tropisetron | 1995 |
Central versus peripheral site of action of the tachykinin NK1-antagonist RP 67580 in inhibiting chemonociception.
Topics: Analgesics; Animals; Blood Pressure; Blood-Brain Barrier; Capsaicin; Female; Hydrochloric Acid; Indoles; Injections, Intraperitoneal; Injections, Intravenous; Injections, Spinal; Injections, Subcutaneous; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Stereoisomerism; Substance P | 1995 |
Nociceptive responses to intrathecally administered substance P and somatostatin in diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain; Pain Measurement; Pain Threshold; Somatostatin; Substance P | 1993 |
Lack of potent antinociceptive activity by substance P antagonist CP-96,345 in the rat spinal cord.
Topics: Analgesics; Analysis of Variance; Animals; Binding, Competitive; Biphenyl Compounds; In Vitro Techniques; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Spinal Cord; Substance P | 1993 |
Substance P receptor desensitization in the dorsal horn: possible involvement of receptor-G protein complexes.
Topics: Animals; Binding, Competitive; Cell Membrane; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Hot Temperature; Kinetics; Male; Pain; Physical Stimulation; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Spinal Cord; Substance P; Time Factors | 1993 |
Theophylline-induced nociceptive behavioral response in mice: possible indirect interaction with spinal N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Male; Mice; Pain; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic; Spinal Cord; Substance P; Theophylline | 1993 |
CP-96,345, but not its stereoisomer, CP-96,344, blocks the nociceptive responses to intrathecally administered substance P and to noxious thermal and chemical stimuli in the rat.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Formaldehyde; Heart Rate; Hot Temperature; Injections, Spinal; Male; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Spinal Cord; Stereoisomerism; Substance P | 1993 |
Cerebrospinal fluid levels of substance P and calcitonin-gene-related peptide: correlation with sural nerve levels and neuropathic signs in sensory diabetic polyneuropathy.
Topics: Calcitonin Gene-Related Peptide; Diabetic Neuropathies; Female; Humans; Male; Middle Aged; Pain; Substance P; Sural Nerve | 1993 |
Cold water swim stress inhibits the nociceptive responses to intrathecally administered somatostatin, but not substance P.
Topics: Animals; Cold Temperature; Male; Mice; Mice, Inbred ICR; Naloxone; Pain; Receptors, Opioid, delta; Somatostatin; Stress, Physiological; Substance P; Swimming | 1993 |
Differential roles of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Buspirone; Male; Mice; Morphine; N-Methylaspartate; Pain; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Substance P; Synaptic Transmission | 1993 |
Substance P markedly potentiates the antinociceptive effects of morphine sulfate administered at the spinal level.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Synergism; Hyperalgesia; Injections, Spinal; Male; Morphine; Neurons; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Time Factors | 1993 |
Quantitative analysis of substance P and calcitonin gene-related peptide immunohistochemical staining in the dorsal horn of neuropathic MK-801-treated rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Dizocilpine Maleate; Immunohistochemistry; Male; Pain; Perfusion; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 1993 |
Antinociception induced by CP 96,345, a non-peptide NK-1 receptor antagonist, in the mouse formalin and capsaicin tests.
Topics: Analgesics; Animals; Biphenyl Compounds; Capsaicin; Dose-Response Relationship, Drug; Formaldehyde; Hypnotics and Sedatives; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Naloxone; Pain; Pain Measurement; Postural Balance; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
Effects of mexiletine on formalin-induced nociceptive responses in mice.
Topics: Animals; Diabetes Mellitus, Experimental; Formaldehyde; Injections, Intraperitoneal; Injections, Spinal; Male; Mexiletine; Mice; Mice, Inbred ICR; Nociceptors; Pain; Somatostatin; Streptozocin; Substance P | 1993 |
Substance P-like immunoreactivity and analgesic effects of vibratory stimulation on patients suffering from chronic pain.
Topics: Adult; Aged; Analgesia; Chronic Disease; Female; Humans; Male; Middle Aged; Pain; Pain Management; Pain Measurement; Physical Stimulation; Radioimmunoassay; Substance P; Vibration | 1993 |
The ganglioside GM1 decreases autotomy but not substance P depletion in a peripheral mononeuropathy rat model.
Topics: Animals; Behavior, Animal; Disease Models, Animal; G(M1) Ganglioside; Male; Pain; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Self Mutilation; Spinal Cord; Substance P | 1993 |
Pain in dreams.
Topics: Adult; Brain; Brain Stem; Dreams; Female; Humans; Leg; Limbic System; Male; Pain; Pilot Projects; Sleep, REM; Substance P; Wakefulness | 1993 |
International Symposium on Substance P and Related Peptides: Pain, Inflammation, Visceral and CNS Functions. Proceedings. Shizuoka, Japan, November 3-6, 1992.
Topics: Animals; Central Nervous System; Humans; Inflammation; Pain; Substance P; Viscera | 1993 |
Spantide-induced antinociception in the opioid mechanism.
Topics: Analgesics; Analysis of Variance; Animals; Brain; Cell Membrane; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Naloxone; Pain; Receptors, Opioid; Spinal Cord; Substance P | 1993 |
Participation of spinal cord substance P in hyperalgesia induced by repeated cold stress.
Topics: Animals; Cold Temperature; Hyperalgesia; Male; Pain; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Spinal Cord; Stress, Physiological; Substance P; Synapses; Synaptic Transmission | 1993 |
Desensitizing mechanism of capsaicin and nonanoyl vanillylamide on the vascular nociceptive response in the guinea pig.
Topics: Acetylcholine; Animals; Bradykinin; Capsaicin; Ganglia, Spinal; Guinea Pigs; Injections, Intra-Arterial; Injections, Spinal; Injections, Subcutaneous; Male; Pain; Spinal Cord; Substance P; Vanillic Acid; Vocalization, Animal | 1993 |
The amino-terminus of substance P mimics and MK-801 attenuates the effects of capsaicin on nociception and kainic acid-induced behavior in the mouse.
Topics: Analysis of Variance; Animals; Capsaicin; Dizocilpine Maleate; Haloperidol; Kainic Acid; Male; Mice; Pain; Peptide Fragments; Piperazines; Receptors, N-Methyl-D-Aspartate; Substance P | 1993 |
Further evidence that substance P is a mediator of both neurogenic inflammation and pain: two phenomena inhibited either by postsynaptic blockade of NK1 receptors or by presynaptic action of opioid receptor agonists.
Topics: Analgesics; Animals; Anticonvulsants; Electric Stimulation; Formaldehyde; Indoles; Inflammation; Isoindoles; Male; Mice; Mice, Inbred Strains; Morphine; Pain; Peripheral Nerves; Pyrroles; Rats; Rats, Sprague-Dawley; Substance P; Thiophenes | 1993 |
Receptor characterization of the spinal action of neurokinins on nociception: a three receptor hypothesis.
Topics: Animals; Benzamides; Biphenyl Compounds; Models, Neurological; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oligopeptides; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Neurotransmitter; Spinal Cord; Substance P | 1993 |
Non-specific activity of (+/-)CP-96,345 in models of pain and inflammation.
Topics: Animals; Biphenyl Compounds; Carrageenan; Dose-Response Relationship, Drug; Edema; Hyperalgesia; Hypnotics and Sedatives; Inflammation; Neurokinin-1 Receptor Antagonists; Pain; Rats; Stereoisomerism; Substance P; Time Factors; Verapamil | 1993 |
Effect of CP-96,345 a non-peptide substance P antagonist, capsaicin, resiniferatoxin and ruthenium red on nociception.
Topics: Action Potentials; Analgesics; Animals; Biphenyl Compounds; Capsaicin; Diterpenes; Hot Temperature; Injections, Spinal; Pain; Peripheral Nerves; Rats; Ruthenium Red; Spinal Cord; Spinal Nerve Roots; Stereoisomerism; Substance P | 1993 |
Antinociceptive effects in the formalin and capsaicin tests after intrathecal administration of substance P analogues in mice.
Topics: Analgesics; Animals; Capsaicin; Drug Interactions; Formaldehyde; Injections, Spinal; Male; Mice; Naloxone; Pain; Substance P | 1993 |
The analgesia induced by intrathecal injection of ruthenium red.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Formaldehyde; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Nociceptors; Pain; Pain Measurement; Ruthenium Red; Substance P | 1993 |
Morphometric model of normal rabbit dorsal root ganglia.
Topics: Animals; Ganglia, Spinal; Low Back Pain; Microscopy, Electron; Models, Neurological; Neurons; Pain; Rabbits; Substance P; Vasoactive Intestinal Peptide; Vibration | 1993 |
Immunohistochemical determination of rat spinal cord substance P, and antinociceptive effect during development of thiamine deficiency.
Topics: Animals; Behavior, Animal; Diet; Fluorescent Antibody Technique, Direct; Growth; Hot Temperature; Immunohistochemistry; Male; Pain; Pain Threshold; Rats; Rats, Wistar; Spinal Cord; Substance P; Thiamine Deficiency | 1995 |
The role of spinal neurokinin-2 receptors in the processing of nociceptive information from the joint and in the generation and maintenance of inflammation-evoked hyperexcitability of dorsal horn neurons in the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arthritis; Benzamides; Carrageenan; Hyperalgesia; Iontophoresis; Kaolin; Knee Joint; Male; Neurokinin A; Nociceptors; Pain; Piperidines; Pressure; Rats; Rats, Wistar; Receptors, Neurokinin-2; Spinal Cord; Substance P | 1996 |
Kappa-opioid receptor modulation of the release of substance P in the dorsal horn.
Topics: Animals; Basal Metabolism; Dynorphins; Hindlimb; Hot Temperature; Intercellular Signaling Peptides and Proteins; Male; Pain; Peptide Fragments; Peptides; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Opioid, kappa; Spinal Cord; Substance P | 1996 |
Central origins of substance P-like immunoreactive fibers and terminals in the spinal trigeminal caudal subnucleus in the rat.
Topics: Animals; Brain Mapping; Fluorescent Antibody Technique; Fluorescent Dyes; Histocytochemistry; Immunohistochemistry; Male; Nerve Endings; Nerve Fibers; Pain; Periaqueductal Gray; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Stilbamidines; Substance P; Trigeminal Caudal Nucleus | 1996 |
Chromic gut suture reduces calcitonin-gene-related peptide and substance P levels in the spinal cord following chronic constriction injury in the rat.
Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Chromium Compounds; Chronic Disease; Constriction, Pathologic; Male; Nerve Tissue Proteins; Pain; Peripheral Nerve Injuries; Peripheral Nerves; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; Substance P; Sutures | 1996 |
Altered sensory behaviors in mice following manipulation of endogenous spinal adenosine neurotransmission.
Topics: Adenosine; Animals; Deoxyadenosines; Grooming; Male; Mice; Neurotransmitter Agents; Pain; Spinal Cord; Substance P; Theophylline | 1996 |
The spinal contribution of substance P to the generation and maintenance of inflammatory hyperalgesia in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Biphenyl Compounds; Carrageenan; Dose-Response Relationship, Drug; Foot; Formaldehyde; Hot Temperature; Hyperalgesia; Inflammation; Male; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 1996 |
Delta-Opioid receptor modulation of the release of substance P-like immunoreactivity in the dorsal horn of the rat following mechanical or thermal noxious stimulation.
Topics: Animals; Decerebrate State; Enkephalin, Methionine; Functional Laterality; Hindlimb; Hot Temperature; Male; Naltrexone; Narcotic Antagonists; Pain; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid, delta; Spinal Cord; Substance P; Time Factors | 1996 |
Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons.
Topics: Action Potentials; Animals; Ganglia, Spinal; Inflammation; Male; Nerve Fibers, Myelinated; Nerve Growth Factors; Neurons, Afferent; Pain; Phenotype; Photomicrography; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 1996 |
Neuropeptides in the arthritic TMJ and symptoms and signs from the stomatognathic system with special consideration to rheumatoid arthritis.
Topics: Adult; Arthritis; Arthritis, Rheumatoid; Calcitonin Gene-Related Peptide; Female; Humans; Inflammation Mediators; Male; Middle Aged; Neuroimmunomodulation; Neurokinin A; Neuropeptide Y; Neuropeptides; Pain; Pain Measurement; Range of Motion, Articular; Statistics, Nonparametric; Substance P; Synovial Fluid; Temporomandibular Joint Disorders | 1995 |
LY303870, a centrally active neurokinin-1 antagonist with a long duration of action.
Topics: Animals; Drug Synergism; Electroshock; Formaldehyde; Guinea Pigs; Humans; Indoles; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Motor Activity; Neurokinin-1 Receptor Antagonists; Pain; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Reflex, Startle; Species Specificity; Spinal Cord; Substance P | 1997 |
Central modulation of Brewer's yeast-induced peripheral inflammation by neuropeptides bradykinin and substance P.
Topics: Analgesics; Animals; Bradykinin; Edema; Inflammation; Male; Pain; Rats; Rats, Sprague-Dawley; Saccharomyces cerevisiae; Substance P | 1996 |
Distributional changes in substance P nociceptive fiber patterns in naturally osteoarthritic articulations.
Topics: Animals; Cartilage, Articular; Horses; Immunohistochemistry; Metacarpophalangeal Joint; Nociceptors; Osteoarthritis; Pain; Radiography; Substance P | 1997 |
Substance P and enkephalin immunoreactivities in axonal boutons presynaptic to physiologically identified dorsal horn neurons. An ultrastructural multiple-labelling study in the cat.
Topics: Animals; Axons; Cats; Dendrites; Enkephalins; Female; Male; Microscopy, Immunoelectron; Models, Neurological; Neurons; Pain; Presynaptic Terminals; Spinal Cord; Substance P | 1997 |
Innervation of the lumbar facet joints. Origins and functions.
Topics: Animals; Antibody Specificity; Calcitonin Gene-Related Peptide; Cell Count; Cholera Toxin; Dopamine beta-Hydroxylase; Ganglia, Spinal; Ganglia, Sympathetic; Immunohistochemistry; Lumbar Vertebrae; Male; Nerve Fibers; Neurons, Afferent; Neuropeptide Y; Pain; Rats; Rats, Sprague-Dawley; Substance P; Vasoactive Intestinal Peptide | 1997 |
Sensitisation of articular afferents in normal and inflamed knee joints by substance P in the rat.
Topics: Animals; Arthritis; Knee Joint; Male; Neurons, Afferent; Pain; Rats; Rats, Wistar; Reference Values; Rotation; Substance P | 1997 |
Low but not high rate noxious radiant skin heating evokes a capsaicin-sensitive increase in spinal cord dorsal horn release of substance P.
Topics: Animals; Behavior, Animal; Capsaicin; Decerebrate State; Hot Temperature; Male; Nociceptors; Pain; Radioimmunoassay; Rats; Rats, Wistar; Skin; Spinal Cord; Substance P | 1997 |
NMDA-receptor regulation of substance P release from primary afferent nociceptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Injections, Spinal; N-Methylaspartate; Neurons, Afferent; Nociceptors; Pain; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Presynaptic; Spinal Cord; Substance P | 1997 |
Dynorphin-(1-8) inhibits the release of substance P-like immunoreactivity in the spinal cord of rats following a noxious mechanical stimulus.
Topics: Animals; Decerebrate State; Dynorphins; Hindlimb; Male; Naltrexone; Pain; Peptide Fragments; Physical Stimulation; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Opioid, kappa; Spinal Cord; Substance P | 1997 |
[Neurophysiology of pain. Current aspects].
Topics: Enkephalins; gamma-Aminobutyric Acid; Humans; Neural Inhibition; Neurons, Afferent; Nociceptors; Pain; Spinal Cord; Spinal Nerves; Substance P; Synaptic Transmission | 1980 |
Increased cerebrospinal fluid concentration of aspartate but decreased concentration of nitric oxide breakdown products in women experiencing visceral pain during active labour.
Topics: Adult; Aged; Analgesia; Aspartic Acid; Cesarean Section; Delivery, Obstetric; Enkephalin, Methionine; Female; Humans; Labor, Obstetric; Metalloendopeptidases; Middle Aged; Nitric Oxide; Pain; Postmenopause; Pregnancy; Reference Values; Substance P | 1997 |
Peptides and neuromas: calcitonin gene-related peptide, substance P, and mast cells in a mechanosensitive human sural neuroma.
Topics: Antibody Specificity; Biopsy; Calcitonin Gene-Related Peptide; Double-Blind Method; Humans; Male; Mast Cells; Mechanoreceptors; Middle Aged; Multicenter Studies as Topic; Myelin Sheath; Neuroma; Neurons; Pain; Peripheral Nervous System Neoplasms; Randomized Controlled Trials as Topic; Substance P; Sural Nerve; Tyrosine 3-Monooxygenase | 1997 |
Inhibition of substance P release from spinal cord tissue after pretreatment with capsaicin does not mediate the antinociceptive effect of capsaicin in adult mice.
Topics: Animals; Capsaicin; Drug Evaluation, Preclinical; Injections, Spinal; Male; Mice; Pain; Perfusion; Spinal Cord; Substance P | 1997 |
Antinociception induced by civamide, an orally active capsaicin analogue.
Topics: Administration, Oral; Analgesics; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Hot Temperature; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Stereoisomerism; Substance P | 1997 |
Plasma extravasation and neuropeptide release in human skin as measured by intradermal microdialysis.
Topics: Adult; Axons; Calcitonin Gene-Related Peptide; Capsaicin; Forearm; Histamine; Humans; Inflammation; Iontophoresis; Microdialysis; Pain; Skin; Substance P; Time Factors | 1997 |
Evidence for nicotinic receptors potentially modulating nociceptive transmission at the level of the primary sensory neuron: studies with F11 cells.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cytosine; Dimethylphenylpiperazinium Iodide; Ganglia, Spinal; Hybrid Cells; Isoxazoles; Mice; Neuroblastoma; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pyridines; Pyrrolidines; Rats; Receptors, Nicotinic; Rubidium; Substance P; Synaptic Transmission | 1997 |
Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor.
Topics: Animals; Capsaicin; Cell Membrane; Cells, Cultured; Fluorescent Antibody Technique; Hyperalgesia; Immunotoxins; Injections, Spinal; N-Glycosyl Hydrolases; Neurons; Pain; Pain Management; Pain Measurement; Plant Proteins; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Signal Transduction; Spinal Cord; Substance P | 1997 |
Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma.
Topics: Animals; Ganglia, Spinal; Gene Deletion; Hyperalgesia; Inflammation; Interneurons; Isoenzymes; Ligation; Mice; Mice, Knockout; Neuropeptide Y; Pain; Pain Management; Pain Threshold; Protein Kinase C; Receptors, Neurokinin-1; Sciatic Nerve; Signal Transduction; Spinal Cord; Substance P | 1997 |
Nerve growth factor- and neurotrophin-3-induced changes in nociceptive threshold and the release of substance P from the rat isolated spinal cord.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Evoked Potentials; GABA Antagonists; GABA-B Receptor Antagonists; Hot Temperature; Hyperalgesia; Hypesthesia; Injections, Subcutaneous; Male; Naloxone; Narcotic Antagonists; Nerve Growth Factors; Neurotrophin 3; Organophosphorus Compounds; Pain; Pain Threshold; Perfusion; Pressure; Rats; Rats, Wistar; Secretory Rate; Single-Blind Method; Spinal Cord; Substance P | 1997 |
Good pain, bad pain.
Topics: Animals; Gene Expression Regulation; Humans; Hyperalgesia; Immunotoxins; Isoenzymes; Mice; Mutation; N-Glycosyl Hydrolases; Neuronal Plasticity; Neurons; Pain; Pain Management; Plant Proteins; Protein Kinase C; Rats; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Signal Transduction; Spinal Cord; Substance P | 1997 |
Antinociceptive properties of the hydroalcoholic extract and preliminary study of a xanthone isolated from Polygala cyparissias (Polygalaceae).
Topics: Abdominal Pain; Acetic Acid; Analgesia; Analgesics; Animals; Aspirin; Bradykinin; Capsaicin; Ethanol; Hot Temperature; Male; Pain; Pain Measurement; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Substance P; Water; Xanthenes; Xanthones | 1997 |
Spinal calmodulin inhibitors reduce N-methyl-D-aspartate- and septide-induced nociceptive behavior.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Enzyme Inhibitors; Imidazoles; Injections, Intraventricular; Male; N-Methylaspartate; Neurokinin A; Pain; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Spinal Cord; Substance P; Sulfonamides | 1997 |
Substance P is not involved in vascular nociception in humans.
Topics: Adult; Humans; Male; Pain; Pain Measurement; Skin; Substance P; Veins | 1997 |
Temporal changes in spinal cord expression of mRNA for substance P, dynorphin and enkephalin in a model of chronic pain.
Topics: Animals; Behavior, Animal; Chronic Disease; Disease Models, Animal; Dynorphins; Enkephalins; Gene Expression; Male; Neuropeptides; Pain; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Substance P; Time Factors | 1997 |
Elevated cerebrospinal fluid substance P-like immunoreactivity in patients with painful osteoarthritis, but not in patients with rhizopatic pain from a herniated lumbar disc.
Topics: Chromatography, Gel; Female; Hip Joint; Humans; Intervertebral Disc Displacement; Knee Joint; Lumbar Vertebrae; Nociceptors; Osteoarthritis, Hip; Pain; Pain Measurement; Radiculopathy; Radioimmunoassay; Substance P | 1997 |
Spinal neurokinin NK1 receptor down-regulation and antinociception: effects of spinal NK1 receptor antisense oligonucleotides and NK1 receptor occupancy.
Topics: Animals; Down-Regulation; Formaldehyde; Indoles; Injections, Spinal; Isoindoles; Male; N-Methylaspartate; Oligonucleotides, Antisense; Pain; Pain Threshold; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1998 |
An antagonist of substance P N-terminal fragments, D-substance P(1-7), reveals that both nociceptive and antinociceptive effects are induced by substance P N-terminal activity during noxious chemical stimulation.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Male; Mice; Pain; Pain Measurement; Peptide Fragments; Stimulation, Chemical; Substance P | 1998 |
Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene.
Topics: Acetic Acid; Alleles; Animals; Biomarkers; Calcitonin Gene-Related Peptide; Formaldehyde; Ganglia, Spinal; Gene Deletion; In Situ Hybridization; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin A; Neurons; Pain; Spinal Cord; Substance P | 1998 |
The nonpeptide NK-1 receptor antagonists LY303870 and LY306740 block the responses of spinal dorsal horn neurons to substance P and to peripheral noxious stimuli.
Topics: Acetamides; Animals; Cats; Electric Stimulation; Indoles; Iontophoresis; Neurokinin-1 Receptor Antagonists; Neurons; Pain; Piperidines; Receptors, Neurokinin-1; Spinal Cord; Stereoisomerism; Substance P | 1998 |
Substance P equals pain substance?
Topics: Analgesics; Animals; Mice; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Pain; Protein Precursors; Receptors, Neurokinin-1; Substance P; Tachykinins | 1998 |
Primary afferent tachykinins are required to experience moderate to intense pain.
Topics: Animals; Cloning, Molecular; Female; Gene Targeting; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Neuritis; Neurokinin A; Nociceptors; Pain; Protein Precursors; Receptors, Neurokinin-1; Sensory Thresholds; Sequence Deletion; Stimulation, Chemical; Substance P; Tachykinins | 1998 |
Altered nociception, analgesia and aggression in mice lacking the receptor for substance P.
Topics: Aggression; Analgesia; Analgesics, Opioid; Animals; Electric Stimulation; Electromyography; Female; Formaldehyde; Gene Targeting; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Mutagenesis; Neuritis; Pain; Pain Threshold; Physical Stimulation; Receptors, Neurokinin-1; Stress, Physiological; Substance P | 1998 |
Evidence for the interaction of glutamate and NK1 receptors in the periphery.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Axons; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Hot Temperature; Hyperalgesia; Male; Microscopy, Immunoelectron; Neurons, Afferent; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Skin; Substance P; Tail | 1998 |
An acid sensing ion channel (ASIC) localizes to small primary afferent neurons in rats.
Topics: Acids; Amino Acid Sequence; Animals; Brain; Calcitonin Gene-Related Peptide; Female; Guinea Pigs; Ion Channels; Male; Molecular Sequence Data; Neurons, Afferent; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 1998 |
Involvement of the central tachykinin NK1 receptor during maintenance of mechanical hypersensitivity induced by diabetes in the rat.
Topics: Animals; Benzofurans; Carbamates; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Electrophysiology; Gerbillinae; Glycine; Guinea Pigs; Humans; Male; Neurokinin-1 Receptor Antagonists; Pain; Pressure; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 1998 |
Ginsenosides induce differential antinociception and inhibit substance P induced-nociceptive response in mice.
Topics: Analgesia; Animals; Central Nervous System Agents; Female; Formaldehyde; Ginsenosides; Mice; Nociceptors; Pain; Panax; Plants, Medicinal; Saponins; Substance P | 1998 |
Pain relief after nerve resection for post-traumatic neuralgia.
Topics: Adult; Female; Follow-Up Studies; Humans; Male; Median Nerve; Middle Aged; Nerve Degeneration; Neuralgia; Nociceptors; Pain; Paresthesia; Patient Satisfaction; Peripheral Nerve Injuries; Peripheral Nerves; Radial Nerve; Recurrence; Sensation Disorders; Substance P; Synaptic Transmission; Treatment Outcome; Ulnar Nerve | 1998 |
[The proximal sesamoid bone of the horse; vascular and neurologic characteristics].
Topics: Animals; Arteries; Calcitonin Gene-Related Peptide; Horse Diseases; Horses; Lameness, Animal; Ligaments; Osteitis; Pain; Sesamoid Bones; Substance P | 1998 |
Pain treatment of fibromyalgia by acupuncture.
Topics: Acupuncture Therapy; Biomarkers; Blood Platelets; Chronic Disease; Female; Fibromyalgia; Humans; Male; Middle Aged; Pain; Pain Management; Pain Measurement; Platelet Count; Serotonin; Substance P; Treatment Outcome | 1998 |
Neurokinin receptors in feline interstitial cystitis.
Topics: Animals; Cat Diseases; Cats; Cystitis, Interstitial; Disease Models, Animal; Iodine Radioisotopes; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Pain; Radiopharmaceuticals; Receptors, Neurokinin-1; Substance P; Tritium | 1998 |
High affinity binding sites for [3H]substance P in urinary bladders of cats with interstitial cystitis.
Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Blood Vessels; Brain; Cats; Cystitis, Interstitial; Female; Iodine Radioisotopes; Male; Neurokinin A; Neurokinin B; Pain; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Substrate Specificity; Tritium; Up-Regulation; Urinary Bladder | 1998 |
Enhancing effect of dimethyl sulfoxide on nociceptive transmission in isolated spinal cord of newborn rat.
Topics: Animals; Animals, Newborn; Capsaicin; Cholinesterases; Dimethyl Sulfoxide; Electric Stimulation; Excitatory Postsynaptic Potentials; Humans; Infant, Newborn; Nerve Fibers; Neurons, Afferent; Nociceptors; Osmotic Pressure; Pain; Potassium Channel Blockers; Rats; Rats, Wistar; Reflex; Spinal Cord; Spinal Nerve Roots; Substance P | 1998 |
Substance P blockade with the potent and centrally acting antagonist GR205171 does not effect central trigeminal activity with superior sagittal sinus stimulation.
Topics: Afferent Pathways; Animals; Brain Mapping; Cats; Cranial Sinuses; Electric Stimulation; Neurokinin-1 Receptor Antagonists; Neurons; Nociceptors; Pain; Piperidines; Proto-Oncogene Proteins c-fos; Spinal Cord; Substance P; Synaptic Transmission; Tetrazoles; Trigeminal Nuclei | 1998 |
The central questions in pain perception may be peripheral.
Topics: Amino Acid Sequence; Animals; Molecular Sequence Data; Pain; Rats; Sensory Thresholds; Substance P | 1998 |
[Chemical anatomy of the nociceptive transmission and modulation in the spinal dorsal horn].
Topics: Animals; Capsaicin; Cats; Glutamates; Nerve Fibers; Neurons, Afferent; Nociceptors; Pain; Rats; Rats, Wistar; Spinal Cord; Substance P | 1996 |
Serum levels of substance P are elevated in patients with sickle cell disease and increase further during vaso-occlusive crisis.
Topics: Acute Disease; Adolescent; Anemia, Sickle Cell; Child; Child, Preschool; Female; Humans; Interleukin-8; Ischemia; Male; Pain; Substance P; Tumor Necrosis Factor-alpha | 1998 |
Swimming capacity of mice is increased by oral administration of a nonpungent capsaicin analog, stearoyl vanillylamide.
Topics: Animals; Blood Glucose; Capsaicin; Epinephrine; Fatty Acids, Nonesterified; Injections, Intravenous; Male; Mice; Pain; Physical Exertion; Substance P; Swimming | 1998 |
Increased substance P in subacromial bursa and shoulder pain in rotator cuff diseases.
Topics: Adult; Aged; Antibodies; Bursa, Synovial; Bursitis; Humans; Middle Aged; Pain; Pain Measurement; Rotator Cuff; Rotator Cuff Injuries; Shoulder Joint; Substance P | 1998 |
Substance P induces brief, localized increase in [Ca2+]i in dorsal horn neurons.
Topics: Animals; Calcium; Cells, Cultured; Dendrites; Fluorescent Dyes; Fura-2; Glutamic Acid; Microscopy, Fluorescence; Neurons; Pain; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1998 |
Slow intrinsic optical signals in the rat spinal dorsal horn in slice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Analgesics; Analgesics, Opioid; Animals; Coloring Agents; Diuretics; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Furosemide; Ganglia, Spinal; Neurons, Afferent; Pain; Rats; Substance P; Substantia Gelatinosa | 1998 |
Comparison of the effects of calmidazolium, morphine and bupivacaine on N-methyl-D-aspartate- and septide-induced nociceptive behaviour.
Topics: Analgesics; Animals; Bupivacaine; Imidazoles; Male; Morphine; N-Methylaspartate; Pain; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Spinal Cord; Substance P | 1998 |
Relationship of substance P, 5-hydroxyindole acetic acid and tryptophan in serum of fibromyalgia patients.
Topics: Adult; Biomarkers; Female; Fibromyalgia; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Pain; Sleep; Substance P; Tryptophan | 1999 |
Calcitonin gene-related peptide and prostaglandin E2 but not substance P release induced by antidromic nerve stimulation from rat skin in vitro.
Topics: Acetamides; Analgesics, Opioid; Animals; Calcitonin Gene-Related Peptide; Dinoprostone; Electric Stimulation; Female; In Vitro Techniques; Male; Membrane Potentials; Nerve Fibers; Neurogenic Inflammation; Nociceptors; Pain; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Skin; Stimulation, Chemical; Substance P; Vasodilation | 1999 |
Actions of intrathecal diphtheria toxin-substance P fusion protein on models of persistent pain.
Topics: Acute Disease; Animals; Carrageenan; Chronic Disease; Constriction, Pathologic; Diphtheria Toxin; Hyperalgesia; Immunohistochemistry; Inflammation; Injections, Spinal; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Sciatic Nerve; Substance P | 1999 |
The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia.
Topics: Amitriptyline; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidepressive Agents, Tricyclic; Clonazepam; Dinoprostone; Disease Models, Animal; Hyperalgesia; Indomethacin; Male; Neuralgia; Pain; Pain Threshold; Peripheral Nerve Injuries; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Saccharomyces cerevisiae; Sciatic Nerve; Seminal Vesicles; Sheep; Substance P | 1999 |
Neurokinin 3 receptors in the gut: a new target for the treatment of visceral pain?
Topics: Analgesics; Animals; Indoles; Isoindoles; Mice; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Pain; Rats; Receptors, Neurokinin-3; Substance P; Visceral Afferents | 1999 |
A role for spinal lamina I neurokinin-1-positive neurons in cold thermoreception in the rat.
Topics: Animals; Body Temperature Regulation; Cold Temperature; Gene Expression Regulation; Genes, fos; Hindlimb; Male; Nociceptors; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Skin; Spinal Cord; Substance P | 1999 |
Low dose of kyotorphin (tyrosine-arginine) induces nociceptive responses through a substance P release from nociceptor endings.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Endorphins; Male; Mice; Mice, Inbred Strains; Nerve Endings; Neurokinin-1 Receptor Antagonists; Pain; Substance P | 1999 |
Chronic pain is associated with increased TrkA immunoreactivity in spinoreticular neurons.
Topics: Afferent Pathways; Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Cell Count; Cell Size; Chronic Disease; Immunohistochemistry; Lumbosacral Region; Male; Nerve Growth Factors; Neuronal Plasticity; Neurons; Pain; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Spinal Cord; Substance P | 1999 |
Evaluation of the efficacy of a bioerodible bupivacaine polymer system on antinociception and inflammatory mediator release.
Topics: Anesthetics, Local; Animals; Biocompatible Materials; Biodegradation, Environmental; Bradykinin; Bupivacaine; Drug Implants; Immunohistochemistry; Inflammation Mediators; Lactic Acid; Male; Microdialysis; Pain; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; Substance P | 1999 |
Tumour necrosis factor-alpha mediates carrageenin-induced knee-joint incapacitation and also triggers overt nociception in previously inflamed rat knee-joints.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Bradykinin; Bradykinin Receptor Antagonists; Carrageenan; Dinoprostone; Inflammation Mediators; Injections, Intra-Articular; Knee Joint; Male; Pain; Rats; Rats, Wistar; Stimulation, Chemical; Substance P; Tumor Necrosis Factor-alpha | 1999 |
Substance P (SP) in innervated and non-innervated blood vessels in the skin of patients with symptomatic scalp.
Topics: Adult; Alopecia; Blood Vessels; Female; Humans; Nervous System Physiological Phenomena; Pain; Scalp; Scalp Dermatoses; Substance P | 1999 |
Lysophosphatidic acid-induced, pertussis toxin-sensitive nociception through a substance P release from peripheral nerve endings in mice.
Topics: Animals; Hindlimb; Lysophospholipids; Male; Mice; Mice, Inbred Strains; Nerve Endings; Neurokinin-1 Receptor Antagonists; Pain; Peripheral Nerves; Pertussis Toxin; Piperidines; Stereoisomerism; Substance P; Time Factors; Virulence Factors, Bordetella | 1999 |
Intrathecal co-administration of NMDA antagonist and NK-1 antagonist reduces MAC of isoflurane in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Anesthetics, Inhalation; Animals; Biphenyl Compounds; Catheters, Indwelling; Drug Combinations; Excitatory Amino Acid Antagonists; Injections, Spinal; Isoflurane; Locomotion; Male; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Substance P; Synaptic Transmission; Valine | 1999 |
Spinal opioid analgesia: how critical is the regulation of substance P signaling?
Topics: Analgesia, Epidural; Analgesics, Opioid; Animals; Cells, Cultured; Embryo, Mammalian; Male; Morphine; Neurokinin-1 Receptor Antagonists; Pain; Piperidines; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Signal Transduction; Spinal Cord; Substance P; Tetrazoles | 1999 |
Transmission of chronic nociception by spinal neurons expressing the substance P receptor.
Topics: Animals; Dose-Response Relationship, Drug; Ganglia, Spinal; Immunotoxins; Inflammation; Ligation; N-Glycosyl Hydrolases; Neuralgia; Pain; Plant Proteins; Posterior Horn Cells; Rats; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Nerves; Substance P; Time Factors | 1999 |
Moxonidine, a selective imidazoline/alpha(2) adrenergic receptor agonist, synergizes with morphine and deltorphin II to inhibit substance P-induced behavior in mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Aggression; Animals; Antihypertensive Agents; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Imidazoles; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Oligopeptides; Pain; Spinal Cord; Substance P | 2000 |
Intrathecally injected neurotrophins and the release of substance P from the rat isolated spinal cord.
Topics: Afferent Pathways; Animals; Electric Stimulation; Glial Cell Line-Derived Neurotrophic Factor; Hot Temperature; In Vitro Techniques; Injections, Spinal; Nerve Growth Factors; Nerve Tissue Proteins; Neurotrophin 3; Pain; Rats; Spinal Cord; Spinal Nerve Roots; Substance P | 2000 |
NK3 receptor blockade prevents hyperalgesia and the associated spinal cord substance P release in monoarthritic rats.
Topics: Afferent Pathways; Animals; Arthritis, Experimental; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Pain; Peptide Fragments; Quinolines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-3; Spinal Cord; Substance P | 2000 |
Elevated substance-P-like immunoreactivity levels in spinal dialysates during the formalin test in normal and diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Formaldehyde; Hindlimb; Hot Temperature; Pain; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Reference Values; Spinal Cord; Substance P | 2000 |
Cytoarchitectonic and immunohistochemical characterization of a specific pain and temperature relay, the posterior portion of the ventral medial nucleus, in the human thalamus.
Topics: Afferent Pathways; Aged; Aged, 80 and over; Calcitonin Gene-Related Peptide; Cell Size; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Neurons; Pain; Spinothalamic Tracts; Substance P; Ventral Thalamic Nuclei | 2000 |
Enhanced nociception by exogenous and endogenous substance P given into the spinal cord in mice lacking NR(2)A/epsilon(1), an NMDA receptor subunit.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Bradykinin; Capsaicin; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Injections, Spinal; Male; Mice; Mice, Knockout; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Pain; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Substance P | 2000 |
Neurokinin 1 receptor expression by neurons in laminae I, III and IV of the rat spinal dorsal horn that project to the brainstem.
Topics: Afferent Pathways; Animals; Axonal Transport; Brain Stem; Cholera Toxin; Hyperalgesia; Male; Microscopy, Confocal; Neurons, Afferent; Pain; Periaqueductal Gray; Posterior Horn Cells; Rats; Receptors, Neurokinin-1; Spinal Cord; Stereotaxic Techniques; Substance P | 2000 |
Upregulation of an opioid-mediated antinociceptive mechanism in transgenic mice over-expressing substance P in the spinal cord.
Topics: Analgesics, Opioid; Animals; Drug Interactions; Female; Gene Expression Regulation; Male; Mice; Mice, Transgenic; Morphine; Naloxone; Narcotic Antagonists; Neurons; Nociceptors; Opioid Peptides; Pain; Pain Measurement; Reaction Time; Spinal Cord; Substance P; Up-Regulation | 2000 |
Immunocytochemical localization of neurokinin B in the rat spinal dorsal horn and its association with substance P and GABA: an electron microscopic study.
Topics: Animals; Axons; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Microscopy, Electron; Neurokinin B; Nociceptors; Pain; Posterior Horn Cells; Rats; Rats, Wistar; Substance P | 2000 |
Characterization of nociceptin/orphanin FQ-induced pain responses in conscious mice: neonatal capsaicin treatment and N-methyl-D-aspartate receptor GluRepsilon subunit knockout mice.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Capsaicin; Consciousness; Immunohistochemistry; Injections, Spinal; Male; Mice; Mice, Knockout; Morphine; Nerve Fibers; Nociceptin; Nociceptors; Opioid Peptides; Pain; Posterior Horn Cells; Receptors, N-Methyl-D-Aspartate; Substance P; Time Factors; Vasodilator Agents | 2000 |
A substance P-opioid chimeric peptide as a unique nontolerance-forming analgesic.
Topics: Analgesics; Animals; Drug Design; Male; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Substance P | 2000 |
Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene.
Topics: Acetic Acid; Animals; Behavior, Animal; Capsaicin; Colon; Cyclophosphamide; Cystitis; Female; Hyperalgesia; Inflammation; Male; Mice; Mice, Knockout; Mustard Plant; Nociceptors; Pain; Physical Stimulation; Plant Extracts; Plant Oils; Receptors, Neurokinin-1; Substance P; Urinary Bladder; Visceral Afferents | 2000 |
Isoprostanes, novel eicosanoids that produce nociception and sensitize rat sensory neurons.
Topics: Action Potentials; Animals; Calcitonin Gene-Related Peptide; Cells, Cultured; Cyclic AMP; Dinoprost; Dinoprostone; F2-Isoprostanes; Female; Isoprostanes; Male; Nerve Fibers; Neurons, Afferent; Pain; Prostaglandins; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P | 2000 |
Inflammation-induced changes in primary afferent-evoked release of substance P within trigeminal ganglia in vivo.
Topics: Animals; Calcium; Capsaicin; Cell Communication; Electric Stimulation; Guinea Pigs; Inflammation; Male; Membrane Potentials; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Substance P; Trigeminal Ganglion | 2000 |
Neuropeptide- and tyrosine hydroxylase-immunoreactive nerve fibers in painful Morton's neuromas.
Topics: Adult; Aged; Antibodies; Calcitonin Gene-Related Peptide; Cell Communication; Female; Foot Diseases; Humans; Male; Middle Aged; Nerve Fibers; Neuroma; Neurons, Afferent; Neuropeptide Y; Neuropeptides; Pain; Substance P; Sympathetic Nervous System; Thiolester Hydrolases; Tyrosine 3-Monooxygenase; Ubiquitin Thiolesterase | 2000 |
Pain control: breaking the circuit.
Topics: Animals; Humans; Immunotoxins; N-Glycosyl Hydrolases; Pain; Plant Proteins; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Cord; Substance P | 2000 |
Collateral projection of substance P receptor expressing neurons in the medullary dorsal horn to bilateral parabrachial nuclei of the rat.
Topics: Animals; Cell Count; Fluorescent Dyes; Male; Medulla Oblongata; Neural Pathways; Neurons; Nociceptors; Pain; Pons; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Trigeminal Caudal Nucleus | 2000 |
Subclassified acutely dissociated cells of rat DRG: histochemistry and patterns of capsaicin-, proton-, and ATP-activated currents.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cluster Analysis; Ganglia, Spinal; Lectins; Male; Neurons, Afferent; Nociceptors; Pain; Patch-Clamp Techniques; Protons; Rats; Rats, Sprague-Dawley; Substance P | 2000 |
Intracellular labeling study of neurons in the superficial part of the magnocellular layer of the medullary dorsal horn of the rat.
Topics: Animals; Axons; Cell Size; Dendrites; Male; Membrane Potentials; Neural Pathways; Neurons; Pain; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Trigeminal Caudal Nucleus | 2000 |
The NK1 receptor is essential for the full expression of noxious inhibitory controls in the mouse.
Topics: Animals; Brain; Brain Stem; Cell Count; Conditioning, Psychological; Crosses, Genetic; Forelimb; Hindlimb; Hot Temperature; Immunohistochemistry; Lumbosacral Region; Mice; Mice, Inbred Strains; Mice, Knockout; Neck; Neural Inhibition; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Proto-Oncogene Proteins c-fos; Receptors, Neurokinin-1; Spinal Cord; Stress, Physiological; Substance P | 2001 |
Decrease in spinal CGRP and substance P is not related to neuropathic pain in a rat model.
Topics: Animals; Calcitonin Gene-Related Peptide; Cold Temperature; Hot Temperature; Male; Pain; Peptide Fragments; Peripheral Nervous System Diseases; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Nerves; Substance P | 2001 |
Reduced antinociception and plasma extravasation in mice lacking a neuropeptide Y receptor.
Topics: Animals; Capsaicin; Gene Targeting; Inflammation; Male; Mice; Mice, Inbred BALB C; Mutagenesis; Pain; Pain Threshold; Plasma; Receptors, Neuropeptide Y; Substance P | 2001 |
The novel analgesic, cizolirtine, inhibits the spinal release of substance P and CGRP in rats.
Topics: Acetic Acid; Analgesics; Anesthesia; Anesthetics, Inhalation; Animals; Aspirin; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Halothane; In Vitro Techniques; Injections, Intraperitoneal; Injections, Spinal; Male; Pain; Potassium; Pyrazoles; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2001 |
Effects of the calcium release inhibitor dantrolene and the Ca2+-ATPase inhibitor thapsigargin on spinal nociception in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Behavior, Animal; Calcium; Calcium-Transporting ATPases; Dantrolene; Enzyme Inhibitors; Male; Muscle Relaxants, Central; N-Methylaspartate; Pain; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Spinal Cord; Substance P; Thapsigargin | 2001 |
Studies on the changes of c-fos protein in spinal cord and neurotransmitter in dorsal root ganglion of the rat with an experimental peripheral neuropathy.
Topics: Animals; Calcitonin Gene-Related Peptide; Ganglia, Spinal; Immunohistochemistry; Neurotransmitter Agents; Pain; Peripheral Nervous System Diseases; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2001 |
Influence of serotonin receptor antagonists on substance P and serotonin release evoked by tooth pulp stimulation with electro-acupuncture in the trigeminal nucleus cudalis of the rabbit.
Topics: Afferent Pathways; Animals; Dental Pulp Cavity; Electric Stimulation; Electroacupuncture; Indoles; Ketanserin; Male; Neurons; Nociceptors; Pain; Pain Management; Piperazines; Rabbits; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Substance P; Trigeminal Caudal Nucleus; Tropisetron | 2001 |
Depletion of substance P, neurokinin A and calcitonin gene-related peptide from the contralateral and ipsilateral caudal trigeminal nucleus following unilateral electrical stimulation of the trigeminal ganglion; a possible neurophysiological and neuroanat
Topics: Animals; Calcitonin Gene-Related Peptide; Electric Stimulation; Female; Functional Laterality; Headache; Male; Neurokinin A; Pain; Rats; Rats, Wistar; Substance P; Trigeminal Ganglion; Trigeminal Nucleus, Spinal | 2001 |
[Peripheral substance P receptor mediating c-fos gene expression in the spinal dorsal horn induced by peripheral noxious stimulation].
Topics: Animals; Ganglia, Spinal; Gene Expression; Genes, fos; Nociceptors; Pain; Proto-Oncogene Proteins c-fos; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1998 |
Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats.
Topics: Amino Acid Sequence; Animals; Calcitonin Gene-Related Peptide; Calcium; Colon; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Immunohistochemistry; Male; Molecular Sequence Data; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance P | 2001 |
Differential roles of spinal cholera toxin- and pertussis toxin-sensitive G proteins in nociceptive responses caused by formalin, capsaicin, and substance P in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Cholera Toxin; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; GTP-Binding Proteins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Neurons; Nociceptors; Pain; Pain Measurement; Pain Threshold; Pertussis Toxin; Spinal Cord; Substance P; Synaptic Transmission; Virulence Factors, Bordetella | 2001 |
Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway.
Topics: Animals; Gene Expression Regulation; Genes, fos; Hyperalgesia; Inflammation; Male; Mice; Mice, Knockout; Pain; Prostaglandins; Rats; Rats, Wistar; Receptor, PAR-2; Receptors, Neurokinin-1; Receptors, Thrombin; Spinal Cord; Substance P | 2001 |
Vanilloid receptor VR1 is both presynaptic and postsynaptic in the superficial laminae of the rat dorsal horn.
Topics: Afferent Pathways; Animals; Ganglia, Spinal; Immunohistochemistry; Male; Microscopy, Electron; Nerve Fibers; Nerve Fibers, Myelinated; Nociceptors; Pain; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Drug; Spinal Nerve Roots; Substance P; Synaptic Membranes; Synaptophysin | 2001 |
Peripheral inflammation reduces the response of spinal dorsal horn neurons to an NK3 receptor agonist.
Topics: Action Potentials; Animals; Carrageenan; Hyperalgesia; Inflammation; Lysine; Neurokinin B; Nociceptors; Pain; Peptide Fragments; Posterior Horn Cells; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P | 2001 |
Microinjection of carbachol in the lateral hypothalamus produces opposing actions on nociception mediated by alpha(1)- and alpha(2)-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Analgesia; Animals; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Efferent Pathways; Female; Hypothalamic Area, Lateral; Injections, Spinal; Nociceptors; Norepinephrine; Pain; Pain Measurement; Pons; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Substance P | 2001 |
Substance P and neurokinin A mediate sensory synaptic transmission in young rat dorsal horn neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Age Factors; Analgesics, Opioid; Animals; Calcium Channel Blockers; Calcium Channels, P-Type; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Guanosine Diphosphate; In Vitro Techniques; Neurokinin A; omega-Conotoxin GVIA; Pain; Patch-Clamp Techniques; Phosphinic Acids; Posterior Horn Cells; Propanolamines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Synaptic Transmission; Thionucleotides | 2001 |
Protein kinase C gamma-like immunoreactivity of trigeminothalamic neurons in the medullary dorsal horn of the rat.
Topics: Animals; Cell Count; Immunohistochemistry; Intralaminar Thalamic Nuclei; Isoenzymes; Male; Midline Thalamic Nuclei; Neural Pathways; Neurons; Pain; Posterior Thalamic Nuclei; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Signal Transduction; Substance P; Substantia Gelatinosa; Synaptic Transmission; Thalamus; Trigeminal Caudal Nucleus; Ventral Thalamic Nuclei | 2001 |
Neuronal nitric oxide synthase (nNOS) mRNA is down-regulated, and constitutive NOS enzymatic activity decreased, in thoracic dorsal root ganglia and spinal cord of the rat by a substance P N-terminal metabolite.
Topics: Animals; Arginine; Capsaicin; Ganglia, Spinal; Lumbar Vertebrae; Male; Nerve Degeneration; Nerve Fibers; Neurons, Afferent; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Pain; Peptide Fragments; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Substance P; Thoracic Vertebrae | 2001 |
Protein kinase C gamma-like immunoreactivity in the substantia gelatinosa of the medullary dorsal horn of the rat.
Topics: Afferent Pathways; Animals; Cell Compartmentation; Cell Size; Dendrites; Immunohistochemistry; Isoenzymes; Lectins; Male; Microscopy, Electron; Nociceptors; Pain; Presynaptic Terminals; Protein Kinase C; Rats; Rats, Wistar; Spinal Nerve Roots; Substance P; Substantia Gelatinosa; Synaptic Transmission; Trigeminal Caudal Nucleus | 2001 |
Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors.
Topics: Acid Sensing Ion Channels; Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; COS Cells; Cyclooxygenase Inhibitors; Ganglia, Spinal; Gene Expression; Hyperalgesia; Inflammation; Lectins; Male; Membrane Proteins; Nerve Tissue Proteins; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Patch-Clamp Techniques; Rats; Rats, Wistar; RNA, Messenger; Sodium Channel Blockers; Sodium Channels; Substance P; Transfection | 2001 |
C-FOS expression in the rat brain in response to substance P and neurokinin B.
Topics: Analgesics; Animals; Autonomic Nervous System; Behavior, Animal; Brain; Cardiovascular Physiological Phenomena; Dose-Response Relationship, Drug; Immunohistochemistry; Indoles; Isoindoles; Male; Neurokinin B; Neurokinin-1 Receptor Antagonists; Neurons; Neurosecretory Systems; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Receptors, Tachykinin; Stress, Physiological; Substance P | 2001 |
Presynaptic localization of the carboxy-terminus epitopes of the mu opioid receptor splice variants MOR-1C and MOR-1D in the superficial laminae of the rat spinal cord.
Topics: Afferent Pathways; Alternative Splicing; Animals; Calcitonin Gene-Related Peptide; Epitopes; Immunohistochemistry; Male; Microscopy, Electron; Nerve Fibers; Nociceptors; Pain; Posterior Horn Cells; Presynaptic Terminals; Protein Isoforms; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Substance P; Synaptic Transmission | 2001 |
Chronic morphine exposure increases the phosphorylation of MAP kinases and the transcription factor CREB in dorsal root ganglion neurons: an in vitro and in vivo study.
Topics: Animals; Calcitonin Gene-Related Peptide; Cell Count; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Drug Administration Schedule; Drug Tolerance; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique; Ganglia, Spinal; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morphine; Narcotic Antagonists; Neurons, Afferent; p38 Mitogen-Activated Protein Kinases; Pain; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Substance P | 2001 |
Antinociceptive profiles of aspirin and acetaminophen in formalin, substance P and glutamate pain models.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aspirin; Behavior, Animal; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Foot; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Nociceptors; Pain; Pain Measurement; Receptors, Glutamate; Receptors, Neurokinin-1; Spinal Cord; Substance P; Synaptic Transmission | 2001 |
Involvement of spinal N-methyl-D-aspartate receptors in capsaicin-induced in vivo release of substance P in the rat dorsal horn.
Topics: 2-Amino-5-phosphonovalerate; Animals; Capsaicin; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microdialysis; Nerve Fibers; Nociceptors; Pain; Posterior Horn Cells; Quinoxalines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Substance P; Synapses; Synaptic Transmission | 2001 |
ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity.
Topics: Animals; Butadienes; Disease Models, Animal; Enkephalins; Enzyme Activation; Enzyme Inhibitors; Freund's Adjuvant; Hindlimb; Hyperalgesia; Inflammation; Injections, Spinal; Male; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Pain; Posterior Horn Cells; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Substance P; Up-Regulation | 2002 |
Tooth extraction-induced internalization of the substance P receptor in trigeminal nucleus and spinal cord neurons: imaging the neurochemistry of dental pain.
Topics: Animals; Male; Neurons; Pain; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P; Tooth Extraction; Trigeminal Nucleus, Spinal | 2002 |
Spinal substance P immunoreactivity is enhanced by acute chemical stimulation of the rat prostate.
Topics: Adrenergic alpha-Antagonists; Animals; Fixatives; Formaldehyde; Lumbar Vertebrae; Male; Pain; Prostate; Prostatic Diseases; Rats; Rats, Sprague-Dawley; Sacrococcygeal Region; Spinal Cord; Stimulation, Chemical; Substance P; Sulfonamides; Tamsulosin; Up-Regulation | 2002 |
Substance P, opioid, and catecholamine systems in the mouse central nervous system (CNS).
Topics: Animals; Catecholamines; Central Nervous System; Dopamine beta-Hydroxylase; Humans; Mice; Mice, Knockout; Nociceptors; Opioid Peptides; Pain; Receptors, Neurokinin-1; Substance P | 2002 |
No influence of low-energy extracorporeal shock wave therapy (ESWT) on spinal nociceptive systems.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Female; Immunohistochemistry; Lithotripsy; Lumbar Vertebrae; Male; Pain; Pain Management; Rats; Rats, Wistar; Reference Values; Sensitivity and Specificity; Spinal Cord; Substance P | 2002 |
Sciatic nerve transection decrease substance P immunoreactivity in the lumbosacral spinal cord of the frog (Rana catesbeiana).
Topics: Animals; Densitometry; Immunohistochemistry; Pain; Ranidae; Sciatic Nerve; Spinal Cord; Substance P; Time Factors | 2002 |
Local neurokinin-1 receptor in the knee joint contributes to the induction, but not maintenance, of arthritic pain in the rat.
Topics: Animals; Arthritis; Carrageenan; Dose-Response Relationship, Drug; Knee Joint; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Nociceptors; Pain; Peripheral Nerves; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Weight-Bearing | 2002 |
Cellular basis for the effects of substance P in the periaqueductal gray and dorsal raphe nucleus.
Topics: Animals; Anxiety; Dendrites; Enkephalins; Glutamic Acid; Immunohistochemistry; Male; Microscopy, Electron; Neurons; Pain; Periaqueductal Gray; Presynaptic Terminals; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Serotonin; Substance P; Synaptic Transmission; Tryptophan Hydroxylase | 2002 |
MOR-1-immunoreactive neurons in the dorsal horn of the rat spinal cord: evidence for nonsynaptic innervation by substance P-containing primary afferents and for selective activation by noxious thermal stimuli.
Topics: Afferent Pathways; Animals; Cell Communication; Female; Hot Temperature; Hyperalgesia; Male; Nerve Fibers; Nociceptors; Oligopeptides; Pain; Posterior Horn Cells; Presynaptic Terminals; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Opioid, mu; Substance P; Synaptic Transmission | 2002 |
Adenosine receptor-mediated control of in vitro release of pain-related neuropeptides from the rat spinal cord.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcitonin Gene-Related Peptide; Cholecystokinin; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Neuropeptides; Pain; Phenethylamines; Potassium; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Spinal Cord; Substance P; Xanthines | 2002 |
The neurokinin-2 receptor is not involved in the sensitization of primary afferents of the rat knee joint.
Topics: Animals; Knee Joint; Male; Mechanoreceptors; Nerve Fibers; Neurokinin A; Neurons, Afferent; Pain; Peptide Fragments; Physical Stimulation; Rats; Rats, Wistar; Receptors, Neurokinin-2; Rotation; Substance P | 2002 |
Time-course of the internalization and recycling of neurokinin 1 receptors in rat dorsal horn neurons.
Topics: Animals; Cell Culture Techniques; Cell Membrane; Dendrites; Endocytosis; Immunohistochemistry; Microscopy, Confocal; Nociceptors; Pain; Posterior Horn Cells; Protease Inhibitors; Protein Transport; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Temperature; Time Factors; Transport Vesicles | 2002 |
Biochemical basis of analgesia: metabolism, storage, regulation, and action.
Topics: Analgesia; Bradykinin; Dopamine; Enkephalins; Glutamates; Histamine; Neurotransmitter Agents; Norepinephrine; Opium; Pain; Prostaglandins; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Serotonin; Substance P | 1978 |
Localization of substance P-like immunoreactivity in nerves in the tooth pulp.
Topics: Alveolar Process; Animals; Cats; Cervical Plexus; Denervation; Dental Pulp; Nerve Fibers; Nerve Fibers, Myelinated; Neurons, Afferent; Neurotransmitter Agents; Odontoblasts; Pain; Substance P | 1977 |
Brain peptides: is substance P a transmitter of pain signals?
Topics: Animals; Brain; Endorphins; Ganglia, Spinal; History, 20th Century; Humans; Nerve Endings; Neurotransmitter Agents; Nociceptors; Pain; Spinal Cord; Substance P | 1979 |
Chemical mechanisms in pain modulation.
Topics: Endorphins; Humans; Pain; Substance P; Synaptic Transmission | 1978 |
Neural mechanisms of opiate analgesia.
Topics: Animals; Brain; Brain Chemistry; Brain Stem; Endorphins; Enkephalins; Humans; Morphine; Narcotics; Pain; Rats; Receptors, Opioid; Substance P | 1979 |
Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia.
Topics: Animals; Capsaicin; Fatty Acids, Unsaturated; Hot Temperature; Injections, Spinal; Movement; Nociceptors; Pain; Rats; Spinal Cord; Substance P; Synaptic Transmission | 1979 |
Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P.
Topics: Analgesia; Animals; Axons; Brain; Cerebral Aqueduct; Colchicine; Enkephalins; Fluorescent Antibody Technique; Ganglia, Spinal; Male; Medulla Oblongata; Nerve Endings; Oligopeptides; Pain; Rats; Spinal Cord; Substance P; Substantia Gelatinosa | 1977 |
The origin, distribution and synaptic relationships of substance P axons in rat spinal cord.
Topics: Afferent Pathways; Animals; Astrocytes; Axons; Cats; Dendrites; Immunoenzyme Techniques; Intercellular Junctions; Microscopy, Electron; Pain; Spinal Cord; Substance P; Synapses | 1979 |
Endogenous opioid peptides and the control of pain.
Topics: Analgesia; Animals; Cats; Central Nervous System; Endorphins; Humans; Naloxone; Naltrexone; Pain; Spinal Cord; Substance P; Swine | 1979 |
Neuronal responses to bradykinin.
Topics: Action Potentials; Animals; Bradykinin; Central Nervous System; Interneurons; Neurons; Pain; Rats; Spinal Cord; Substance P; Substantia Nigra | 1978 |
Effect of substance P in cat dorsal horn neurones activated by noxious stimuli.
Topics: Animals; Cats; Evoked Potentials; Neural Inhibition; Neurons; Pain; Spinal Cord; Substance P | 1977 |
Substance P and analgesia.
Topics: Analgesia; Animals; Blister; Drug Tolerance; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Morphine; Pain; Receptors, Drug; Substance P | 1976 |
Release of prostaglandins by bradykinin as an intrinsic mechanism of its algesic effect.
Topics: Acetylcholine; Animals; Bradykinin; Denervation; Ear; Indomethacin; Pain; Prostaglandins; Prostaglandins E; Rabbits; Substance P | 1976 |
Decreased cerebrospinal fluid neuropeptide-converting enzyme activity in monoarthritic rats.
Topics: Animals; Arthritis, Experimental; Cerebrospinal Fluid; Cysteine Endopeptidases; Enkephalin, Leucine; Male; Metalloendopeptidases; Pain; Peptide Fragments; Rats; Rats, Sprague-Dawley; Substance P | 1992 |
Antinociceptive effect of mexiletine in diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Male; Mexiletine; Mice; Mice, Inbred ICR; Nociceptors; Pain; Potassium; Reaction Time; Substance P | 1992 |
Intrathecal co-administration of substance P and NMDA augments nociceptive responses in the formalin test.
Topics: Animals; Formaldehyde; Injections, Spinal; Male; Mice; N-Methylaspartate; Nociceptors; Pain; Pain Measurement; Substance P | 1992 |
Neonatal capsaicin treatment prevents the development of the thermal hyperalgesia produced in a model of neuropathic pain in the rat.
Topics: Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Hot Temperature; Male; Nervous System Diseases; Pain; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 1992 |
Intrathecal oxymetazoline does not produce neurotoxicity in the spinal cord of the rat.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Gait; Immunohistochemistry; Injections, Spinal; Male; Motor Activity; Neurotoxins; Oxymetazoline; Pain; Posture; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 1992 |
[Pain and stress: biological protection].
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Nervous System Physiological Phenomena; Neurotransmitter Agents; Pain; Stress, Physiological; Substance P; Synaptic Transmission; Vasodilation | 1992 |
Changes in peptidergic innervation in chronic pancreatitis.
Topics: Adult; Calcitonin Gene-Related Peptide; Chronic Disease; Female; Humans; Male; Nerve Fibers; Neuropeptide Y; Neuropeptides; Pain; Pancreas; Pancreatitis; Peptide PHI; Substance P; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide | 1992 |
Morphologic and quantitative changes in neurotransmitters in the lumbar spinal cord after acute or chronic mechanical compression of the cauda equina.
Topics: Animals; Cauda Equina; Immunoenzyme Techniques; Nerve Compression Syndromes; Nerve Endings; Neurotransmitter Agents; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Synaptic Transmission | 1992 |
Spinal neurons exhibiting a specific nociceptive response receive abundant substance P-containing synaptic contacts.
Topics: Action Potentials; Animals; Cats; Dendrites; Pain; Spinal Nerves; Substance P; Synapses; Synaptic Transmission | 1992 |
Alterations of spinal dorsal horn substance P following electroacupuncture analgesia--a study of the formalin test with immunohistochemistry and densitometry.
Topics: Animals; Densitometry; Electroacupuncture; Evaluation Studies as Topic; Ganglia, Spinal; Immunohistochemistry; Male; Pain; Pain Management; Rats; Rats, Inbred Strains; Substance P | 1992 |
Effects of intrathecal antibodies to substance P, calcitonin gene-related peptide and galanin on repeated cold stress-induced hyperalgesia: comparison with carrageenan-induced hyperalgesia.
Topics: Animals; Antibodies; Calcitonin Gene-Related Peptide; Carrageenan; Cold Temperature; Galanin; Hyperalgesia; Injections, Spinal; Male; Neuropeptides; Nociceptors; Pain; Peptides; Rats; Rats, Inbred Strains; Sensory Thresholds; Spinal Cord; Stress, Physiological; Substance P | 1992 |
Antinociception induced by microinjection of substance P into the A7 catecholamine cell group in the rat.
Topics: Afferent Pathways; Analgesics; Animals; Blood Pressure; Catecholamines; Dioxanes; Female; Hot Temperature; Idazoxan; Injections, Spinal; Microinjections; Models, Neurological; Neurons; Norepinephrine; Pain; Pons; Rats; Rats, Inbred Strains; Reflex; Serotonin; Skin Temperature; Stereotaxic Techniques; Substance P; Tyrosine 3-Monooxygenase; Yohimbine | 1992 |
Stimulation of 5-HT1 receptors in the spinal cord changes substance P-induced behaviour.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Analgesia; Animals; Indoles; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Nerve Endings; Neurons; Pain; Piperazines; Quipazine; Receptors, Serotonin; Reference Values; Serotonin; Serotonin Antagonists; Spinal Cord; Stereotyped Behavior; Substance P | 1992 |
International symposium on substance P and related peptides. Pain, inflammation, visceral and CNS functions. November 3-6, 1992, Shizuoka, Japan. Abstracts.
Topics: Animals; Central Nervous System; Digestive System Physiological Phenomena; Humans; Inflammation; Pain; Substance P | 1992 |
Differential release of substance P and somatostatin in the rat spinal cord in response to noxious cold and heat; effect of dynorphin A(1-17).
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cold Temperature; Dynorphins; Hot Temperature; Male; Naloxone; Pain; Pyrrolidines; Rats; Rats, Inbred Strains; Somatostatin; Spinal Cord; Substance P | 1990 |
Roles of substance P and somatostatin on transmission of nociceptive information induced by formalin in spinal cord.
Topics: Animals; Capsaicin; Cysteamine; Drug Interactions; Formaldehyde; Mice; Pain; Pain Measurement; Somatostatin; Spinal Cord; Substance P; Synaptic Transmission | 1990 |
Development of supersensitivity to substance P in the spinal cord of the streptozotocin-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Male; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Spinal Cord; Substance P | 1990 |
Substance P causes pain--but also heals.
Topics: Animals; Humans; Inflammation; Pain; Substance P; Wound Healing | 1990 |
The involvement of neurokinin receptor subtypes in somatosensory processing in the superficial dorsal horn of the cat.
Topics: Animals; Axons; Bombesin; Cats; Evoked Potentials, Somatosensory; Glutamates; Glutamic Acid; Hot Temperature; Kinetics; Neurokinin A; Neurons; Pain; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Spinal Cord; Substance P | 1990 |
Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord.
Topics: Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Drug Interactions; Glutamates; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Pain; Pain Measurement; Quisqualic Acid; Rats; Rats, Inbred Strains; Reaction Time; Self Mutilation; Spinal Cord; Substance P; Taurine | 1990 |
The specific antagonistic effect of intrathecal spantide II on substance P- and C-fiber conditioning stimulation-induced facilitation of the nociceptive flexor reflex in rat.
Topics: Amino Acid Sequence; Analgesics; Animals; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Female; Injections, Spinal; Male; Molecular Sequence Data; Nerve Fibers; Neuropeptides; Pain; Rats; Rats, Inbred Strains; Substance P | 1990 |
Evidence that substance P selectively modulates C-fiber-evoked discharges of dorsal horn nociceptive neurons.
Topics: Action Potentials; Animals; Evoked Potentials; In Vitro Techniques; Male; Morphine; Nerve Fibers; Neurons; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1990 |
Innervation of the human knee joint by substance-P fibers.
Topics: Humans; Immunoenzyme Techniques; Knee Joint; Nerve Fibers; Nociceptors; Pain; Patella; Substance P | 1990 |
Effect of intrathecal injection of pertussis toxin on substance P, norepinephrine and serotonin contents in various neural structures of arthritic rats.
Topics: Animals; Arthritis, Experimental; Brain; Freund's Adjuvant; Hydroxyindoleacetic Acid; Injections, Spinal; Male; Nociceptors; Norepinephrine; Pain; Pertussis Toxin; Pons; Rats; Rats, Inbred Strains; Serotonin; Spinal Cord; Substance P; Thalamus; Virulence Factors, Bordetella | 1990 |
[The role of substance P in electroacupuncture analgesia and its relation to enkephalins in the rat brain].
Topics: Acupuncture Analgesia; Animals; Brain; Electroacupuncture; Enkephalin, Leucine; Male; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Substance P | 1990 |
[The influence of P-chlorophenylalanine on the analgesia of electro-acupuncture and the level of SP in CNS of rats].
Topics: Acupuncture Analgesia; Animals; Central Nervous System; Electroacupuncture; Fenclonine; Nociceptors; Pain; Rats; Sensory Thresholds; Substance P | 1990 |
[Relation of capsaicin-sensitive neurones to the effect of electro-acupuncture analgesia].
Topics: Acupuncture Analgesia; Animals; Capsaicin; Electroacupuncture; Male; Nerve Fibers; Neurons; Nociceptors; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Substance P | 1990 |
[Effect of monoamine neurotransmitters, enkephalin and morphine on substance P contents of several brain regions and pain threshold in rats].
Topics: Animals; Biogenic Monoamines; Brain; Corpus Striatum; Enkephalins; Hippocampus; Hypothalamus; Morphine; Neurotransmitter Agents; Pain; Pain Measurement; Rats; Rats, Inbred Strains; Sensory Thresholds; Substance P | 1990 |
The influence of electroacupuncture analgesia on substance P level in the central nervous system of rats.
Topics: Acupuncture Analgesia; Animals; Central Nervous System; Electroacupuncture; Hypothalamus; Male; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Spinal Cord; Substance P | 1990 |
The influence of 5,7-dihydroxytryptamine on the electroacupuncture analgesia and the substance P level in the central nervous system of rats.
Topics: 5,7-Dihydroxytryptamine; Acupuncture Analgesia; Animals; Brain Stem; Electroacupuncture; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Spinal Cord; Substance P | 1990 |
The utility of 2-hydroxypropyl-beta-cyclodextrin as a vehicle for the intracerebral and intrathecal administration of drugs.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; alpha-Cyclodextrins; Analgesia; Animals; beta-Cyclodextrins; Calcitonin Gene-Related Peptide; Capsaicin; Cerebral Ventricles; Cyclodextrins; Dimethyl Sulfoxide; Electroencephalography; Enkephalin, Leucine-2-Alanine; gamma-Cyclodextrins; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Motor Activity; Naloxone; Narcotics; Pain; Pharmaceutical Vehicles; Rats; Rats, Inbred Strains; Solubility; Substance P; Time Factors | 1991 |
Eicosanoid synthesis by spinal cord astrocytes is evoked by substance P; possible implications for nociception and pain.
Topics: Animals; Astrocytes; Eicosanoids; Pain; Spinal Cord; Substance P | 1991 |
Neurochemical mediators of the behavioural effects of receptor-selective substance P agonists administered intrathecally in the rat.
Topics: Animals; Injections, Spinal; Male; Methysergide; Morphine; Muscles; Naloxone; Pain; Peptide Fragments; Phentolamine; Phenylephrine; Posture; Rats; Rats, Inbred Strains; Serotonin; Spinal Cord; Stereotyped Behavior; Substance P | 1990 |
Neonatal capsaicin treatment abolishes the nociceptive responses to intravenous 5-HT in the rat.
Topics: Animals; Animals, Newborn; Behavior, Animal; Calcitonin Gene-Related Peptide; Capsaicin; Hot Temperature; Injections, Intravenous; Male; Nociceptors; Pain; Rats; Rats, Inbred Strains; Reaction Time; Serotonin; Skin Physiological Phenomena; Spinal Cord; Substance P | 1991 |
Intrathecal somatostatin, somatostatin analogs, substance P analog and dynorphin A cause comparable neurotoxicity in rats.
Topics: Animals; Dynorphins; Injections, Spinal; Male; Motor Activity; Neurotoxins; Octreotide; Pain; Peptide Fragments; Rats; Rats, Inbred Strains; Reference Values; Seizures; Somatostatin; Spinal Cord; Stereotyped Behavior; Substance P; Time Factors | 1990 |
Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Naloxone; Nociceptors; Pain; Peptide Fragments; Reaction Time; Substance P; Urethane | 1991 |
Interactions between serotonin and substance P in the spinal regulation of nociception.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics; Animals; Indoles; Injections, Spinal; Male; Metergoline; Mice; Mice, Inbred Strains; Neurons; Pain; Serotonin; Serotonin Antagonists; Skin Temperature; Spinal Cord; Substance P; Tetrahydronaphthalenes | 1991 |
[Effect of intracerebral injection of substance P on serotonin contents of several brain regions and its relation with pain threshold, electroacupuncture analgesia in rats].
Topics: Acupuncture Analgesia; Animals; Brain; Electroacupuncture; Female; Injections, Intraventricular; Male; Microinjections; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Serotonin; Substance P | 1991 |
Neonatal exposure to substance P alters behavioral and substance P levels in the central nervous system of the adult rat.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain Chemistry; Calcitonin Gene-Related Peptide; Central Nervous System; Eye; Female; Fluorescent Antibody Technique; Male; Microchemistry; Pain; Peptide Fragments; Radioimmunoassay; Rats; Rats, Inbred Strains; Sensory Thresholds; Sexual Behavior, Animal; Spectrometry, Fluorescence; Spinal Cord; Substance P; Vagina | 1991 |
Streptozotocin-induced diabetes in mice reduces the nociceptive threshold, as recognized after application of noxious mechanical stimuli but not of thermal stimuli.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Hot Temperature; Male; Mice; Mice, Inbred ICR; Neurons; Pain; Physical Stimulation; Reaction Time; Sensory Thresholds; Somatostatin; Spinal Cord; Substance P; Synaptic Transmission | 1991 |
Activation of primary afferents in the rabbit ear by noxious heat.
Topics: Afferent Pathways; Animals; Bradykinin; Capsaicin; Ear; Hot Temperature; Pain; Potassium; Rabbits; Substance P | 1991 |
Pain, tenderness, wheal and flare induced by substance-P, bradykinin and 5-hydroxytryptamine in humans.
Topics: Adult; Bradykinin; Female; Forearm; Humans; Male; Muscles; Pain; Serotonin; Skin; Skin Tests; Substance P | 1991 |
Autotomy and decreased spinal substance P following peripheral cryogenic nerve lesion.
Topics: Animals; Behavior, Animal; Cryosurgery; Immunohistochemistry; Male; Nerve Degeneration; Pain; Rats; Rats, Inbred Strains; Sciatic Nerve; Spinal Cord; Substance P | 1991 |
Involvement of substance P in hyperalgesia induced by intrathecal galanin.
Topics: Animals; Antibodies, Monoclonal; Behavior, Animal; Capsaicin; Carrageenan; Galanin; Guinea Pigs; Ileum; In Vitro Techniques; Inflammation; Injections, Spinal; Male; Muscle, Smooth; Neurokinin A; Nociceptors; Pain; Peptides; Rats; Rats, Inbred Strains; Substance P | 1991 |
Substance P-mediated slow excitatory postsynaptic potential elicited in dorsal horn neurons in vivo by noxious stimulation.
Topics: Animals; Biphenyl Compounds; Cats; Evoked Potentials; Ganglia, Spinal; Neurons; Nociceptors; Pain; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Spinal Cord; Substance P; Synapses; Time Factors; Touch | 1991 |
[Role of pain component in the organization of chemosensory taste reaction].
Topics: Animals; Capsicum; Chemoreceptor Cells; Fluorescence; Histamine; Histamine Release; Histocytochemistry; Male; Pain; Pain Measurement; Plants, Medicinal; Rats; Substance P; Taste; Taste Buds; Tongue | 1991 |
Novel substance P antagonist, CP-96,345, blocks responses of cat spinal dorsal horn neurons to noxious cutaneous stimulation and to substance P.
Topics: Animals; Biphenyl Compounds; Cats; Evoked Potentials; Hot Temperature; Neurons; Pain; Skin; Spinal Cord; Substance P | 1991 |
Neurones with epileptiform discharge in the central nervous system and chronic pain. Experimental and clinical investigations.
Topics: Animals; Chronic Disease; Cortical Spreading Depression; Electroencephalography; Epilepsy; Evoked Potentials; Humans; Locus Coeruleus; Neurons; Pain; Raphe Nuclei; Rats; Somatosensory Cortex; Substance P; Thalamic Nuclei | 1991 |
Release of substance P into the superficial dorsal horn following nociceptive activation of the hindpaw of the rat.
Topics: Animals; Formaldehyde; Hindlimb; Kinetics; Pain; Rats; Spinal Cord; Substance P; Time Factors | 1991 |
Substance P in chronic pain.
Topics: Adrenocorticotropic Hormone; Back Pain; beta-Endorphin; Chronic Disease; Electric Stimulation Therapy; Electrodes, Implanted; Humans; Pain; Spinal Cord; Substance P; Time Factors | 1991 |
Substance P and the sensory innervation of intracranial and extracranial feline cephalic arteries. Implications for vascular pain mechanisms in man.
Topics: Animals; Arteries; Cats; Cerebral Arteries; Chromatography, High Pressure Liquid; Cranial Nerves; Guinea Pigs; Head; Humans; Neurons, Afferent; Pain; Sensation; Skull; Substance P; Trigeminal Nuclei | 1985 |
Characterization of spinal actions of four substance P analogues.
Topics: Animals; Male; Motor Activity; Pain; Physalaemin; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Spinal Cord; Substance P | 1985 |
The contribution of neurogenic inflammation in experimental arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Arthritis, Rheumatoid; Brain Stem; Humans; Inflammation; Nociceptors; Pain; Rats; Spinal Cord; Substance P; Sympathetic Nervous System | 1985 |
Characterization of the hyperalgesic effect induced by intrathecal injection of substance P.
Topics: Animals; Injections, Spinal; Male; Morphine; Naloxone; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1985 |
Long-term high frequency transcutaneous electrical nerve stimulation (hi-TNS) in chronic pain. Clinical response and effects on CSF-endorphins, monoamine metabolites, substance P-like immunoreactivity (SPLI) and pain measures.
Topics: Adult; Aged; Chronic Disease; Electric Stimulation Therapy; Endorphins; Female; Follow-Up Studies; Glycols; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Middle Aged; Pain; Pain Management; Phenylacetates; Radioimmunoassay; Substance P; Transcutaneous Electric Nerve Stimulation | 1985 |
Antinociceptive and neurotoxic actions of substance P analogues in the rat's spinal cord after intrathecal administration.
Topics: Analgesics; Animals; Injections, Spinal; Male; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Spinal Cord Diseases; Substance P | 1985 |
Alterations of immunoreactive substance P and enkephalins in rat spinal cord after electroacupuncture.
Topics: Acupuncture Therapy; Animals; Electric Stimulation; Enkephalins; Functional Laterality; Male; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Spinal Cord; Substance P | 1985 |
Acetylsalicylic acid, paracetamol and morphine inhibit behavioral responses to intrathecally administered substance P or capsaicin.
Topics: Acetaminophen; Animals; Aspirin; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Morphine; Pain; Substance P | 1985 |
Non-opiate analgesia following stressful acoustic stimulation.
Topics: Acoustic Stimulation; Analgesia; Animals; Diltiazem; Endorphins; Male; Morphine; Naloxone; Pain; Rats; Rats, Inbred Strains; Sincalide; Stress, Physiological; Substance P | 1985 |
Noradrenergic inhibition of the release of substance P from the primary afferents in the rabbit spinal dorsal horn.
Topics: Adrenergic Fibers; Animals; Decerebrate State; Male; Neural Inhibition; Neurons, Afferent; Norepinephrine; Pain; Rabbits; Receptors, Adrenergic, alpha; Spinal Cord; Substance P | 1985 |
Influence of substance P on nociception and stress.
Topics: Analgesics; Animals; Injections, Intraperitoneal; Mice; Nociceptors; Pain; Sensory Thresholds; Stress, Physiological; Structure-Activity Relationship; Substance P | 1985 |
Desensitization to substance P following intrathecal injection. A technique for investigating the role of substance P in nociception.
Topics: Animals; Baclofen; Injections, Spinal; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Substance P; Time Factors | 1985 |
Capsaicin in adult frogs: effects on nociceptive responses to cutaneous stimuli and on nervous tissue concentrations of immunoreactive substance P, somatostatin and cholecystokinin.
Topics: Animals; Brain Chemistry; Capsaicin; Cholecystokinin; Chromatography, Gel; Electric Stimulation; Hot Temperature; Nerve Tissue; Pain; Radioimmunoassay; Rana esculenta; Sensory Thresholds; Somatostatin; Spinal Cord; Stimulation, Chemical; Substance P; Time Factors | 1985 |
[Substance P displays opposite effects on electroacupuncture analgesia in the periaqueductal gray matter and spinal cord of the rabbit].
Topics: Acupuncture Therapy; Animals; Electric Stimulation Therapy; Male; Pain; Periaqueductal Gray; Rabbits; Sensory Thresholds; Spinal Cord; Substance P; Transcutaneous Electric Nerve Stimulation | 1985 |
[The effect of acupuncture "Zusanli" on the substance P-evoked nociceptive responses of the dorsal horn neurons in the rat].
Topics: Acupuncture Therapy; Animals; Electric Stimulation; Male; Pain; Rats; Spinal Cord; Substance P | 1985 |
Substance P and somatostatin modulate spinal cord excitability via physiologically different sensory pathways.
Topics: Action Potentials; Afferent Pathways; Animals; Electric Stimulation; Hot Temperature; Neurons, Afferent; Pain; Rats; Reflex; Somatostatin; Spinal Cord; Substance P | 1986 |
Procedures which increase acute pain sensitivity also increase autotomy.
Topics: Animals; Burns; Denervation; Foot Injuries; Male; Norepinephrine; Pain; Pargyline; Peripheral Nerves; Rats; Rats, Inbred Strains; Self Mutilation; Sensation; Substance P | 1986 |
Intradermal hypertonic saline-induced behavior as a nociceptive test in mice.
Topics: Animals; Anti-Inflammatory Agents; Baclofen; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Intradermal; Injections, Spinal; Male; Mice; Morphine; Nalorphine; Pain; Pentazocine; Saline Solution, Hypertonic; Sodium Chloride; Spinal Cord; Substance P | 1986 |
Possible neurohumoral mechanisms in CNS stimulation for pain suppression.
Topics: Brain; Chronic Disease; Electric Stimulation Therapy; Electrodes, Implanted; Ganglia, Spinal; Humans; Neurotransmitter Agents; Pain; Pain Management; Periaqueductal Gray; Spinal Cord; Substance P | 1985 |
Interaction of bradykinin with substance P on vascular permeability and pain response.
Topics: Animals; Bradykinin; Capillary Permeability; Drug Synergism; Foot; Inflammation; Male; Mice; Pain; Substance P | 1986 |
Analgesic activities of spinal cord substance P antagonists implicate substance P as a neurotransmitter of pain sensation.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Injections, Spinal; Iodine Radioisotopes; Mice; Pain; Piperazines; Somatostatin; Substance P | 1986 |
Nociceptive behavior after intrathecal injections of substance P, neurokinin A and calcitonin gene-related peptide in mice.
Topics: Animals; Calcitonin Gene-Related Peptide; Female; Injections, Spinal; Mice; Neurokinin A; Neuropeptides; Pain; Peripheral Nerves; Spinal Cord; Substance P; Thermosensing | 1986 |
Regulatory mechanisms for substance P in the dorsal horn during a nociceptive stimulus: axoplasmic transport vs electrical activity.
Topics: Animals; Axonal Transport; Colchicine; Electrophysiology; Female; Formaldehyde; Nociceptors; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Tetrodotoxin | 1986 |
Effects of opioids and opioid peptide on the release of substance P-like material induced by tooth pulp stimulation in the trigeminal nucleus caudalis of the rabbit.
Topics: Animals; Dental Pulp; Electric Stimulation; Enkephalin, Methionine; Male; Morphine; Naloxone; Pain; Rabbits; Substance P; Trigeminal Nuclei | 1986 |
Evidence that substance P may be a modulator rather than a transmitter of noxious mechanical stimulation.
Topics: Animals; Injections, Spinal; Male; Nociceptors; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Spinal Cord; Substance P; Synaptic Transmission | 1986 |
Noxious heating of the skin releases immunoreactive substance P in the substantia gelatinosa of the cat: a study with antibody microprobes.
Topics: Action Potentials; Animals; Antibodies; Cats; Hot Temperature; Nociceptors; Pain; Pain Measurement; Skin; Spinal Cord; Substance P | 1987 |
Calcitonin gene-related peptide promotes mechanical nociception by potentiating release of substance P from the spinal dorsal horn in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Neuropeptides; Nociceptors; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1987 |
Substance P-induced long-term blockade of spinal adrenergic analgesia: reversal by morphine and naloxone.
Topics: Analgesia; Animals; Clonidine; Kinetics; Male; Morphine; Naloxone; Norepinephrine; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Time Factors; Yohimbine | 1987 |
Increased sensitivity to intrathecal substance P following chronic administration of zimelidine.
Topics: Animals; Behavior, Animal; Drug Interactions; Injections, Spinal; Mice; Pain; Pain Measurement; Substance P; Zimeldine | 1987 |
Release of substance P from the spinal dorsal horn is enhanced in polyarthritic rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Decerebrate State; Male; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Synaptic Transmission | 1987 |
Effects of substance P analogues in the rat tail-flick test.
Topics: Animals; Male; Pain; Paralysis; Physalaemin; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds; Substance P | 1987 |
Changes in nociception after acute and chronic administration of zimelidine: different effects in the formalin test and the substance P behavioural assay.
Topics: Animals; Behavior, Animal; Formaldehyde; Male; Mice; Pain; Substance P; Zimeldine | 1987 |
Behavioural assessment as substance P antagonists in mice.
Topics: Analgesia; Analgesics; Animals; Behavior, Animal; Male; Mice; Mice, Inbred Strains; Pain; Structure-Activity Relationship; Substance P | 1987 |
Effect of capsaicin upon afferent and efferent mechanisms of nociception and temperature regulation in birds.
Topics: Afferent Pathways; Animals; Birds; Body Temperature Regulation; Capsaicin; Chickens; Columbidae; Ducks; Efferent Pathways; Nociceptors; Pain; Rats; Sciatic Nerve; Spinal Cord; Substance P | 1987 |
The role of substance P and other neuropeptides in transmission of pain.
Topics: Animals; Neurons, Afferent; Neuropeptides; Pain; Substance P | 1987 |
Evolution of substance P immunofluorescent nerves in callus tissue during fracture healing.
Topics: Animals; Bony Callus; Female; Fluorescent Antibody Technique; Male; Pain; Rats; Rats, Inbred Strains; Substance P; Tibial Fractures; Wound Healing | 1987 |
Intrathecal administration of substance P in the rat: spinal transection or morphine blocks the behavioural responses but not the facilitation of the tail flick reflex.
Topics: Animals; Behavior, Animal; Denervation; Injections, Spinal; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Reaction Time; Reflex; Spinal Cord; Substance P; Tail | 1988 |
Behavioural effects of intrathecally injected tachykinins in rats with peripheral nerve transection.
Topics: Animals; Autacoids; Behavior, Animal; Denervation; Eledoisin; Injections, Spinal; Male; Neuropeptides; Pain; Peripheral Nerves; Physalaemin; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Tachykinins | 1987 |
Dual action of substance P in nociception and pain modulation at spinal level.
Topics: Animals; Bicuculline; Efferent Pathways; Naloxone; Neurons; Nociceptors; Pain; Rats; Spinal Cord; Substance P | 1987 |
Enkephalins interact with substance P-induced aversive behaviour in mice.
Topics: Animals; beta-Endorphin; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Methionine; Injections, Spinal; Mice; Nociceptors; Pain; Reaction Time; Substance P | 1988 |
Desensitization to intrathecal substance P in mice: possible involvement of opioids.
Topics: Animals; Behavior, Animal; Drug Resistance; Endorphins; Female; Injections, Spinal; Male; Mice; Nociceptors; Pain; Substance P | 1988 |
Spinal cord neuropeptides in a case of chronic pain.
Topics: Calcitonin Gene-Related Peptide; Chronic Disease; Humans; Immunohistochemistry; Male; Middle Aged; Neuropeptides; Pain; Spinal Cord; Substance P | 1988 |
Substance P in CSF of patients with chronic pain syndromes.
Topics: Adult; Aged; Chronic Disease; Depression; Female; Humans; Male; Middle Aged; Nervous System Diseases; Pain; Pain, Intractable; Personality Inventory; Substance P; Syndrome | 1988 |
[Effects of substance P and its fragments in physiological and pathological pain].
Topics: Animals; Male; Pain; Pain Measurement; Peptide Fragments; Raphe Nuclei; Rats; Rats, Inbred Strains; Substance P | 1988 |
N- and C-terminal fragments of substance P: spinal effects in the rat tail flick test.
Topics: Animals; Male; Pain; Peptide Fragments; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1988 |
Is substance P a primary afferent neurotransmitter for nociceptive input? II. Spinalization does not reduce and intrathecal morphine potentiates behavioral responses to substance P.
Topics: Animals; Decerebrate State; Drug Interactions; Glutamates; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Morphine; Nociceptors; Pain; Picrotoxin; Rats; Rats, Inbred Strains; Spinal Cord; Strychnine; Substance P | 1988 |
Is substance P a primary afferent neurotransmitter for nociceptive input? I. Analysis of pain-related behaviors resulting from intrathecal administration of substance P and 6 excitatory compounds.
Topics: Afferent Pathways; Animals; Capsaicin; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Morphine; Nociceptors; Pain; Picrotoxin; Rats; Rats, Inbred Strains; Spinal Cord; Strychnine; Substance P | 1988 |
Is substance P a primary afferent neurotransmitter for nociceptive input? III. Valproic acid and chlordiazepoxide decrease behaviors elicited by intrathecal injection of substance P and excitatory compounds.
Topics: Animals; Anticonvulsants; Chlordiazepoxide; Injections, Spinal; Kainic Acid; Male; Morphine; Nociceptors; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Strychnine; Substance P; Valproic Acid | 1988 |
Is substance P a primary afferent neurotransmitter for nociceptive input? IV. 2-Amino-5-phosphonovalerate (APV) and [D-Pro2,D-Trp7,9]-substance P exert different effects on behaviors induced by intrathecal substance P, strychnine and kainic acid.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Drug Interactions; Injections, Spinal; Kainic Acid; Male; Morphine; Nociceptors; Pain; Peptide Fragments; Rats; Rats, Inbred Strains; Spinal Cord; Strychnine; Substance P; Valine | 1988 |
Behavior induced by putative nociceptive neurotransmitters is inhibited by adenosine or adenosine analogs coadministered intrathecally.
Topics: Adenosine; Animals; Aspartic Acid; Behavior, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Spinal; Male; Mice; N-Methylaspartate; Neurotransmitter Agents; Pain; Substance P | 1988 |
Intrathecal substance P modulates the depressant effect of 5-methoxy-N,N-dimethyltryptamine on a reflex response to radiant heat in mice.
Topics: Animals; Hot Temperature; Injections, Spinal; Male; Methoxydimethyltryptamines; Mice; Pain; Receptors, Serotonin; Reflex; Serotonin; Substance P; Tail | 1988 |
An adrenal-mediated, naloxone-reversible increase in reaction time in the tail-flick test following intrathecal administration of substance P at the lower thoracic spinal level in the rat.
Topics: Adrenal Medulla; Animals; Endorphins; Injections, Spinal; Male; Naloxone; Oxytocin; Pain; Rats; Rats, Inbred Strains; Reaction Time; Substance P; Thyrotropin-Releasing Hormone | 1988 |
A study of beta-endorphin and substance P level in cerebrospinal fluid on lumbar lesion.
Topics: Adult; Aged; Endorphins; Female; Humans; Intervertebral Disc Displacement; Male; Middle Aged; Pain; Spinal Stenosis; Substance P | 1987 |
Facilitation of the tail-flick reflex by noxious cutaneous stimulation in the rat: antagonism by a substance P analogue.
Topics: Animals; Hot Temperature; Injections, Spinal; Male; Pain; Rats; Rats, Inbred Strains; Reaction Time; Spinal Cord; Substance P | 1988 |
Some ultrastructure and immunocytochemical findings taken as morphological basis for the gate control theory of pain mechanism.
Topics: Animals; Enkephalins; Immunohistochemistry; Nociceptors; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Synapses | 1988 |
[Roles of substance P and somatostatin on transmission of nociceptive information in the spinal cord].
Topics: Animals; Nociceptors; Pain; Somatostatin; Spinal Cord; Substance P; Synaptic Transmission | 1987 |
The role of neurotransmitters in processing painful stimuli.
Topics: Humans; Neurons, Afferent; Neurotransmitter Agents; Pain; Spinal Cord; Substance P; Synaptic Transmission | 1989 |
The pain of discography.
Topics: Animals; Coloring Agents; Dogs; Ganglia, Spinal; Injections, Spinal; Intervertebral Disc; Osmolar Concentration; Pain; Radiography; Substance P; Vasoactive Intestinal Peptide | 1988 |
[Implication of serotoninergic and peptidergic systems in the mechanisms of pain].
Topics: Animals; Enkephalins; Neuropeptides; Pain; Rats; Serotonin; Substance P | 1988 |
Increased reactivity to chemical but not to heat noxious stimuli in mice producing anti-idiotypic antibodies for substance P.
Topics: Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Formaldehyde; Hot Temperature; Immunoglobulin Idiotypes; Male; Mice; Mice, Inbred BALB C; Pain; Substance P | 1988 |
Excitatory transmitters, ventral root potentials and [K+]o in the isolated frog leg-spinal cord preparation.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; In Vitro Techniques; Kynurenic Acid; Pain; Physical Stimulation; Potassium; Rana pipiens; Spinal Nerve Roots; Substance P; Valine | 1988 |
Enhancement of preprotachykinin A gene expression by adjuvant-induced inflammation in the rat spinal cord: possible involvement of substance P-containing spinal neurons in nociception.
Topics: Animals; Gene Expression Regulation; Inflammation; Male; Pain; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Sensory Thresholds; Spinal Cord Diseases; Substance P; Tachykinins; Time Factors | 1989 |
Long-lasting neurochemical and functional changes in rats induced by neonatal administration of substance P antiserum.
Topics: Animals; Animals, Newborn; Antibodies; Blood Pressure; Enkephalin, Methionine; Hydroxyindoleacetic Acid; Male; Pain; Periaqueductal Gray; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1989 |
Further evidence for possible analgesic mechanism of electroacupuncture: effects on neuropeptides and serotonergic neurons in rat spinal cord.
Topics: Acupuncture Therapy; Analgesia, Epidural; Animals; Baclofen; Electric Stimulation; Enkephalin, Methionine; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Serotonin; Spinal Cord; Substance P | 1989 |
Subsensitivity to substance P in SART-stressed mice.
Topics: Animals; Behavior, Animal; Cold Temperature; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Pain; Sensory Thresholds; Statistics as Topic; Stress, Physiological; Substance P | 1989 |
Somatostatin: evidence for a role in thermal nociception.
Topics: Animals; Cats; Hot Temperature; Pain; Somatostatin; Spinal Cord; Substance P | 1989 |
Stimulus specificity of peripherally evoked substance P release from the rabbit dorsal horn in situ.
Topics: Animals; Formaldehyde; Hot Temperature; Male; Pain; Physical Stimulation; Rabbits; Spinal Cord; Substance P | 1989 |
Electrical stimulation of primary afferent A fibres does not reduce substance P release in the dorsal horn of the cat.
Topics: Animals; Cats; Electric Stimulation; Hot Temperature; Neurons, Afferent; Pain; Physical Stimulation; Spinal Cord; Substance P | 1989 |
Effects of lysergic acid diethylamide (LSD) and adjuvant-induced inflammation on desensitization to and metabolism of substance P in the mouse spinal cord.
Topics: Adjuvants, Immunologic; Animals; Drug Tolerance; Female; Inflammation; Lysergic Acid Diethylamide; Male; Mice; Pain; Peptide Fragments; Spinal Cord; Substance P | 1989 |
[Pain and chemical transmitters].
Topics: Animals; Enkephalins; gamma-Aminobutyric Acid; Ganglia, Spinal; Neurotransmitter Agents; Nociceptors; Pain; Rats; Substance P | 1988 |
Relation between the therapeutic effect of moxibustion in treating arthralgia and SP and enkephalin in nervous tissues.
Topics: Animals; Arthritis; Arthritis, Experimental; Enkephalin, Leucine; Male; Moxibustion; Pain; Rats; Rats, Inbred Strains; Sciatic Nerve; Sensory Thresholds; Spinal Cord; Substance P | 1989 |
[Hyperalgetic effect of low doses of myelopeptides].
Topics: Animals; Bone Marrow; Mice; Mice, Inbred Strains; Oligopeptides; Pain; Peptides; Sensory Thresholds; Substance P | 1989 |
Substance P and peripheral inflammatory hyperalgesia.
Topics: Animals; Dose-Response Relationship, Drug; Hyperalgesia; Hyperesthesia; Inflammation; Male; Pain; Rats; Rats, Inbred Strains; Substance P | 1989 |
Naloxone blocks the formalin-induced increase of substance P in the dorsal horn.
Topics: Animals; Female; Formaldehyde; Immunoenzyme Techniques; Morphine; Naloxone; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1989 |
Modified formalin test: characteristic biphasic pain response.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Bromelains; Capsaicin; Dexamethasone; Dose-Response Relationship, Drug; Formaldehyde; Indomethacin; Male; Mice; Morphine; Nerve Fibers; p-Methoxy-N-methylphenethylamine; Pain; Pain Measurement; Sciatic Nerve; Substance P; Time Factors | 1989 |
Analgesic mechanism of neurotropin: relation to the serotonergic system and influence of spinal cord transection.
Topics: Analgesics; Animals; Behavior, Animal; Cisterna Magna; Cyproheptadine; Decerebrate State; Fenclonine; Injections; Male; Mice; Mice, Inbred Strains; Pain; Polysaccharides; Reaction Time; Receptors, Serotonin; Spinal Cord; Substance P | 1989 |
Modulation of pain in fibromyalgia (fibrositis syndrome): cerebrospinal fluid (CSF) investigation of pain related neuropeptides with special reference to calcitonin gene related peptide (CGRP).
Topics: Calcitonin Gene-Related Peptide; Female; Fibromyalgia; Humans; Neuropeptides; Pain; Palliative Care; Peptide Fragments; Radioimmunoassay; Substance P | 1989 |
Blockage of substance P-induced scratching behavior in rats by the intrathecal administration of inhibitory amino acid agonists.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Glycine; Injections, Spinal; Muscimol; Pain; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, GABA-A; Substance P; Taurine | 1989 |
[The effect of substance P on the neuronal activity of the antinociceptive system].
Topics: Animals; Hot Temperature; Male; Microelectrodes; Neurons; Pain; Raphe Nuclei; Rats; Rats, Inbred Strains; Reaction Time; Substance P | 1989 |
[The change of the concentration of substance P in the rats "channel" "point" skin and plasma in the acupuncture analgesia].
Topics: Acupuncture Analgesia; Acupuncture Points; Animals; Electroacupuncture; Female; Male; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Skin; Substance P | 1989 |
Sympathetic neurons modulate plasma extravasation in the rat through a non-adrenergic mechanism.
Topics: Alprostadil; Animals; Blister; Hydroxydopamines; Inflammation; Male; Neurons; Neurons, Afferent; Neurons, Efferent; Nociceptors; Norepinephrine; Oxidopamine; Pain; Plasma; Prostaglandins; Rats; Rats, Inbred Strains; Substance P; Sympathectomy, Chemical; Sympathetic Nervous System | 1989 |
Evidence that substance P and somatostatin transmit separate information related to pain in the spinal dorsal horn.
Topics: Animals; Hot Temperature; Male; Nociceptors; Pain; Physical Stimulation; Rabbits; Somatostatin; Spinal Cord; Substance P; Synaptic Transmission; Thermoreceptors | 1985 |
[Lars Terenius about neuropeptides and pain: Endorphines alleviate stress--a curative effect? A new spinal-active analgesic insight. Interview by Birgit Lindell].
Topics: Analgesics; Dynorphins; Endorphins; Humans; Pain; Receptors, Opioid; Receptors, Opioid, kappa; Substance P | 1985 |
[Antipyretics, analgesics and plasmakinins].
Topics: Analgesics; Angiotensin II; Bradykinin; Humans; Kallidin; Kinins; Pain; Peptides; Substance P | 1970 |
Action of peptides and other algesic agents on paravascular pain receptors of the isolated perfused rabbit ear.
Topics: Acetylcholine; Action Potentials; Adenosine; Adenosine Triphosphate; Angiotensin II; Animals; Blood Pressure; Drug Synergism; Ear; Eledoisin; Epinephrine; Female; Histamine; In Vitro Techniques; Male; Oxytocin; Pain; Peptides; Potassium Chloride; Prostaglandins; Rabbits; Respiration; Sensory Receptor Cells; Serotonin; Substance P; Time Factors; Vasoconstrictor Agents; Vasodilator Agents; Vasopressins; Venous Pressure | 1974 |