silicon and Anemia

Serum, erythrocyte and renal tissue silicon levels in normal Wister rats and in rats with chronic renal failure were examined. The relationship between serum, erythrocyte and renal tissue Si levels, and markers of renal function (BUN, serum creatinine), markers of anemia (RBC, Hb, Hct) and markers of bone formation (serum calcium, phosphate) were studied. Serum and erythrocyte Si levels were directly correlated with the markers of renal function and with serum Pi and serum Ca x P, and inversely with the markers of anemia. Renal tissue silicon levels, on the other hand, correlated only with the markers of anemia.

Topics: Anemia; Animals; Blood Urea Nitrogen; Calcium; Creatinine; Erythrocyte Count; Hematocrit; Kidney Failure, Chronic; Leukocyte Count; Male; Nephrectomy; Phosphates; Rats; Rats, Wistar; Silicon

We examined the relationship between recombinant human erythropoietin (rHuEPO) therapy and serum levels of the trace elements aluminum, silicon, zinc, nickel, and manganese in 55 patients undergoing chronic hemodialysis (HD) in whom rHuEPO (for 12 weeks) was effective in reducing anemia, and in 55 patients undergoing HD without rHuEPO treatment. In the rHuEPO group, serum Al level was significantly decreased and Si level showed a tendency to decrease. Zn, Ni, and Mn levels, however, were significantly increased.

Topics: Adult; Aged; Aluminum; Anemia; Combined Modality Therapy; Erythropoietin; Female; Humans; Kidney Failure, Chronic; Male; Manganese; Middle Aged; Nickel; Renal Dialysis; Silicon; Trace Elements; Zinc

Topics: Aluminum; Anemia; Erythropoietin; Female; Humans; Immunologic Factors; Male; Middle Aged; Renal Dialysis; Silicon; Trace Elements

Abnormalities of trace elements such as aluminum, silicon, zinc, manganese and nickel were found in chronic hemodialysis (HD) patients. The relationship between serum concentration of trace elements and complications such as anemia bone disease, neurological disorder and nutritional disorder in 100 chronic HD patients was examined. Serum Al and Si levels were very high in these patients, and were negatively correlated with indicators of anemia such as RBC, hemoglobin and hematocrit values. Serum Al and Si levels in the HD patients with peripheral neurological disorder (excluding encephalopathy) and with bone disease were significantly high. The levels of serum Zn, Mn and Ni were low, and were correlated with total serum protein levels. In summary, in order to prevent some complications in chronic HD patients, it is very important to regulate levels of trace elements.

Topics: Aluminum; Anemia; Deferoxamine; Female; Hematocrit; Hemoglobins; Humans; Kidney Failure, Chronic; Male; Manganese; Middle Aged; Nickel; Reference Values; Renal Dialysis; Silicon; Spectrophotometry, Atomic; Trace Elements; Zinc