Page last updated: 2024-11-04

sevoflurane and Ache

sevoflurane has been researched along with Ache in 58 studies

Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.

Research Excerpts

ExcerptRelevanceReference
"Since the introduction of propofol, several drugs and methods have been used to alleviate the pain on its injection."9.15Sevoflurane to alleviate pain on propofol injection. ( Ali, MS; DeSousa, K, 2011)
"Omission of fentanyl did not reduce the overall incidence of postoperative nausea and vomiting, but did reduce the incidence of vomiting and/or moderate to severe nausea prior to discharge from 20% and 17% with fentanyl and fentanyl-dexamethasone, respectively, to 5% (P = 0."9.13Omitting fentanyl reduces nausea and vomiting, without increasing pain, after sevoflurane for day surgery. ( Bridgman, S; Smith, I; Walley, G, 2008)
"We investigated the early recovery characteristics and pain relief of adult patients during combined anesthesia with (epidural and general), either with propofol or sevoflurane for maintenance in major abdominal surgery."9.11Propofol and sevoflurane during epidural/general anesthesia: comparison of early recovery characteristics and pain relief. ( Duru, S; Elar, Z; Hepağuşlar, H; Ozkardeşler, S; Ozzeybek, D; Taşdöğen, A, 2004)
"The general anesthetic sevoflurane is being repurposed as a topical analgesic for painful chronic wounds."8.02Cost-effectiveness analysis of domiciliary topical sevoflurane for painful leg ulcers. ( Cortiñas-Sáenz, M; Fernández-Ginés, FD; Gerónimo-Pardo, M; Selva-Sevilla, C, 2021)
"To investigate the correlation between the pain rating index (PRi), which is an index derived from processed electroencephalography signals, and the end-tidal sevoflurane concentration (ETsevo)."8.02Correlation between pain rating index and end-tidal sevoflurane concentration during sevoflurane anesthesia. ( Lv, ZG; Wang, BG; Wang, Z; Zhang, JW; Zhang, WW, 2021)
"Recently, it has been reported that topical irrigations of liquid sevoflurane on the bed of painful wounds produce a rapid, intense, and lasting analgesic effect."7.96Pain reduction of topical sevoflurane vs intravenous opioids in pressure ulcers. ( Agudo-Ponce, D; Cortiñas-Sáenz, M; Fernández-Ginés, FD; Fernández-Sánchez, C; Mateo-Carrasco, H; Morales-Molina, JA; Navajas-Gómez de Aranda, A; Sierra-García, F, 2020)
"The aim of this study is to evaluate the use and safety of a sedation protocol with sevoflurane for short painful procedures in newborns."7.91Sevoflurane for Short Painful Procedures in the Neonatal Intensive Care Unit. ( Cabrera, M; Elorza, MD; Gomez, F; Lopez-Ortego, P; Sanabria, P; Sanchez, L, 2019)
"Topical application of sevoflurane to painful wounds produced a rapid, robust, and long-lasting analgesic effect, which allowed for a high degree of wound debridement."7.91Analgesic effectiveness of topical sevoflurane to perform sharp debridement of painful wounds. ( Gerónimo-Pardo, M; Martínez-Monsalve, A; Selva-Sevilla, C, 2019)
" Finally, intrathecal L-arginine alone did not affect the basal pain threshold, but it significantly decreased the antinociceptive response of emulsified sevoflurane against formalin injection and the suppressive effects of sevoflurane on formalin-induced Fos protein expression (P<0."7.81Intrathecal L-arginine reduces the antinociception of sevoflurane in formalin-induced pain in rats. ( Chen, JQ; Dai, TJ; Tang, QF; Zeng, YM, 2015)
"Preoperative anxiety and pain sensitivity are independent predictors of propofol and sevoflurane requirements in general anaesthesia."7.78Preoperative anxiety and pain sensitivity are independent predictors of propofol and sevoflurane requirements in general anaesthesia. ( Chung, WY; Hong, JY; Kil, HK; Kim, GH; Kim, WO; Seo, H, 2012)
"These findings show that sevoflurane administration after ischemia does not provide neuroprotection in rats subjected to incomplete cerebral ischemia."7.76Sevoflurane-induced post-conditioning has no beneficial effects on neuroprotection after incomplete cerebral ischemia in rats. ( Choi, JH; DO, HS; Jee, DL; Kim, YW; Lee, DH; Lee, HM; Lee, SR; Park, SJ, 2010)
"The aim of the present study was to examine the level of unconsciousness measured with bispectral index (BIS) at different minimal alveolar concentration (MAC) levels of sevoflurane, and to study the hemodynamic and BIS reactions during noxious stimulation with transcutaneous electrical nerve stimulation (TENS) and an ice water pain test (IWP)."7.74Effects of pain stimulation on bispectral index, heart rate and blood pressure at different minimal alveolar concentration values of sevoflurane. ( Axelsson, K; Dahlqvist, A; Sandin, M; Thörn, SE; Wattwil, L; Wattwil, M, 2008)
"The authors previously reported changes in electroencephalographic bicoherence during isoflurane anesthesia combined with epidural anesthesia."7.72Electroencephalographic bicoherence is sensitive to noxious stimuli during isoflurane or sevoflurane anesthesia. ( Hagihira, S; Mashimo, T; Mori, T; Takashina, M; Ueyama, H, 2004)
"Pain caused an increase in prehypoxic baseline ventilation before and during sevoflurane inhalation: C = 13."7.69Acute pain and central nervous system arousal do not restore impaired hypoxic ventilatory response during sevoflurane sedation. ( Berkenbosch, A; Dahan, A; Olofsen, E; Sarton, E; Teppema, L; van den Elsen, M; van Kleef, J, 1996)
"Sevoflurane consumption was lower in PRi group than in SBP group (15."7.01Comparison of blood pressure and pain rating index used for depth regulation of sevoflurane anaesthesia. ( Bai, L; Lv, Z; Wang, B; Zhang, J, 2021)
" However, no significant intergroup differences were observed in the pain score, parental satisfaction, the incidence of propofol rescue and NPOBCs."5.69Sucking lollipop after awakening from sevoflurane anesthesia reduces the degree of emergence agitation in children undergoing ambulatory surgery: A prospective randomized controlled trial. ( Huang, F; Mo, X; Wu, X; Zeng, J; Zhang, K, 2023)
"Since the introduction of propofol, several drugs and methods have been used to alleviate the pain on its injection."5.15Sevoflurane to alleviate pain on propofol injection. ( Ali, MS; DeSousa, K, 2011)
"To compare the efficacy and safety of sevoflurane deep sedation with glucose and nonnutritive sucking (GNNS) in reducing the duration of the procedure and in preventing pain-related effects during peripherally inserted central catheter (PICC) placement."5.14Sevoflurane for central catheter placement in neonatal intensive care: a randomized trial. ( DI Marco, JN; Garbi, A; Hassid, S; Lagier, P; Martin, C; Michel, F; Nicaise, C; Thomachot, L; Vialet, R, 2010)
"Omission of fentanyl did not reduce the overall incidence of postoperative nausea and vomiting, but did reduce the incidence of vomiting and/or moderate to severe nausea prior to discharge from 20% and 17% with fentanyl and fentanyl-dexamethasone, respectively, to 5% (P = 0."5.13Omitting fentanyl reduces nausea and vomiting, without increasing pain, after sevoflurane for day surgery. ( Bridgman, S; Smith, I; Walley, G, 2008)
"We investigated the early recovery characteristics and pain relief of adult patients during combined anesthesia with (epidural and general), either with propofol or sevoflurane for maintenance in major abdominal surgery."5.11Propofol and sevoflurane during epidural/general anesthesia: comparison of early recovery characteristics and pain relief. ( Duru, S; Elar, Z; Hepağuşlar, H; Ozkardeşler, S; Ozzeybek, D; Taşdöğen, A, 2004)
"To investigate the correlation between the pain rating index (PRi), which is an index derived from processed electroencephalography signals, and the end-tidal sevoflurane concentration (ETsevo)."4.02Correlation between pain rating index and end-tidal sevoflurane concentration during sevoflurane anesthesia. ( Lv, ZG; Wang, BG; Wang, Z; Zhang, JW; Zhang, WW, 2021)
"The general anesthetic sevoflurane is being repurposed as a topical analgesic for painful chronic wounds."4.02Cost-effectiveness analysis of domiciliary topical sevoflurane for painful leg ulcers. ( Cortiñas-Sáenz, M; Fernández-Ginés, FD; Gerónimo-Pardo, M; Selva-Sevilla, C, 2021)
"Recently, it has been reported that topical irrigations of liquid sevoflurane on the bed of painful wounds produce a rapid, intense, and lasting analgesic effect."3.96Pain reduction of topical sevoflurane vs intravenous opioids in pressure ulcers. ( Agudo-Ponce, D; Cortiñas-Sáenz, M; Fernández-Ginés, FD; Fernández-Sánchez, C; Mateo-Carrasco, H; Morales-Molina, JA; Navajas-Gómez de Aranda, A; Sierra-García, F, 2020)
"The aim of this study is to evaluate the use and safety of a sedation protocol with sevoflurane for short painful procedures in newborns."3.91Sevoflurane for Short Painful Procedures in the Neonatal Intensive Care Unit. ( Cabrera, M; Elorza, MD; Gomez, F; Lopez-Ortego, P; Sanabria, P; Sanchez, L, 2019)
"Topical application of sevoflurane to painful wounds produced a rapid, robust, and long-lasting analgesic effect, which allowed for a high degree of wound debridement."3.91Analgesic effectiveness of topical sevoflurane to perform sharp debridement of painful wounds. ( Gerónimo-Pardo, M; Martínez-Monsalve, A; Selva-Sevilla, C, 2019)
"Analgesic mouse models were established by intraperitoneal injection of emulsified sevoflurane, and the influence of p-MPPF (a specific antagonist of 5-HT1A Rs) intrathecal injection on the changes in tail-flick latency in tail-withdrawal test, pain threshold in hot-plate test (HPPT), and writhing times in acetic acid-induced writhing test were recorded."3.855-HT1A Receptors Mediate Analgesia Induced by Emulsified Sevoflurane in Thermal Nociception but Have Little Effect on Chemical Nociception. ( Gao, C; Hong, T; Shen, J; Ti-Jun, D; Xin, L; Yan, C; Zhi-Xiu, M, 2017)
"This study suggests that sevoflurane, but not intravenous anesthetics, inhibits pain-related anxiety, along with ERK activation in the ACC, probably through inhibition of spinal nociceptive transmission."3.81Differential effects of general anesthetics on anxiety-like behavior in formalin-induced pain: involvement of ERK activation in the anterior cingulate cortex. ( Dai, RP; Li, CQ; Luo, C; Luo, W; Xu, JM; Zhang, YL; Zhou, FH, 2015)
" Finally, intrathecal L-arginine alone did not affect the basal pain threshold, but it significantly decreased the antinociceptive response of emulsified sevoflurane against formalin injection and the suppressive effects of sevoflurane on formalin-induced Fos protein expression (P<0."3.81Intrathecal L-arginine reduces the antinociception of sevoflurane in formalin-induced pain in rats. ( Chen, JQ; Dai, TJ; Tang, QF; Zeng, YM, 2015)
"Preoperative anxiety and pain sensitivity are independent predictors of propofol and sevoflurane requirements in general anaesthesia."3.78Preoperative anxiety and pain sensitivity are independent predictors of propofol and sevoflurane requirements in general anaesthesia. ( Chung, WY; Hong, JY; Kil, HK; Kim, GH; Kim, WO; Seo, H, 2012)
" Baseline brain activity was altered by inducing anesthesia (sevoflurane end-tidal concentration 1%) in human volunteers and fc-fMRI maps between the pre-anesthetized and anesthetized conditions were compared across different brain networks."3.76Functional connectivity and alterations in baseline brain state in humans. ( Constable, RT; Martuzzi, R; Qiu, M; Rajeevan, N; Ramani, R, 2010)
"These findings show that sevoflurane administration after ischemia does not provide neuroprotection in rats subjected to incomplete cerebral ischemia."3.76Sevoflurane-induced post-conditioning has no beneficial effects on neuroprotection after incomplete cerebral ischemia in rats. ( Choi, JH; DO, HS; Jee, DL; Kim, YW; Lee, DH; Lee, HM; Lee, SR; Park, SJ, 2010)
" After having established the mice model of hypnosis and analgesia by intraperitoneal injections of appropriate doses of enflurane, isoflurane or sevoflurane, we intracerebroventricularly or intrathecally injected different doses of nicotine and then observed the effects on the sleeping time using awaken test and the pain threshold in hot-plate test (HPPT) using hot-plate test."3.75Nicotinic acetylcholine receptors mediate the hypnotic and analgesic effects of emulsified inhalation anesthetics. ( Dai, TJ; Yan, S; Zeng, YM, 2009)
" After having established the mouse model of analgesia by intraperitoneal or subcutaneous injections of appropriate doses of emulsified enflurane, isoflurane or sevoflurane, we injected different doses of AMPA intrathecally and observed effects on the pain threshold using the hot-plate and acetic acid-induced writhing tests."3.74Spinal alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors may mediate the analgesic effects of emulsified halogenated anaesthetics. ( Dai, TJ; Hang, LH; Shao, DH; Yang, YH; Zeng, YM, 2007)
"The aim of the present study was to examine the level of unconsciousness measured with bispectral index (BIS) at different minimal alveolar concentration (MAC) levels of sevoflurane, and to study the hemodynamic and BIS reactions during noxious stimulation with transcutaneous electrical nerve stimulation (TENS) and an ice water pain test (IWP)."3.74Effects of pain stimulation on bispectral index, heart rate and blood pressure at different minimal alveolar concentration values of sevoflurane. ( Axelsson, K; Dahlqvist, A; Sandin, M; Thörn, SE; Wattwil, L; Wattwil, M, 2008)
"The authors previously reported changes in electroencephalographic bicoherence during isoflurane anesthesia combined with epidural anesthesia."3.72Electroencephalographic bicoherence is sensitive to noxious stimuli during isoflurane or sevoflurane anesthesia. ( Hagihira, S; Mashimo, T; Mori, T; Takashina, M; Ueyama, H, 2004)
"Pain caused an increase in prehypoxic baseline ventilation before and during sevoflurane inhalation: C = 13."3.69Acute pain and central nervous system arousal do not restore impaired hypoxic ventilatory response during sevoflurane sedation. ( Berkenbosch, A; Dahan, A; Olofsen, E; Sarton, E; Teppema, L; van den Elsen, M; van Kleef, J, 1996)
"Sevoflurane consumption was lower in PRi group than in SBP group (15."3.01Comparison of blood pressure and pain rating index used for depth regulation of sevoflurane anaesthesia. ( Bai, L; Lv, Z; Wang, B; Zhang, J, 2021)
"Rocuronium 0."2.76A short period of inhalation induction with sevoflurane prevents rocuronium-induced withdrawal in children. ( Goo, EK; Hwang, JW; Kim, CS; Kim, JH; Min, SW; Nahm, FS; Oh, AY; Park, SH; Shin, NR, 2011)
"Times to early emergence and tracheal extubation were significantly shorter with LFGF SS than TCI (5."2.73Low fresh gas flow balanced anesthesia versus target controlled intravenous infusion anesthesia in laparoscopic cholecystectomy: a cost-minimization analysis. ( Dobrasinovic, J; Miljkovic, B; Perunovic, R; Petrova, G; Scepanovic, R; Stevanovic, PD; Stojanovic, D, 2008)
"Sevoflurane is a volatile liquid from the family of ether-derived alogenated hydrocarbons that is approved for the induction and  maintenance of inhalational general anesthesia in the hospital setting."2.72Topical sevofluran: a galenic experience. ( Cortiñas-Sáenz, M; Fernández-Ginés, FD; Gerónimo-Pardo, M, 2021)
"Increasingly more aged people with Alzheimer's disease (AD) must undergo surgery with general anesthesia for various reasons."1.40Smaller sized inhaled anesthetics have more potency on senescence-accelerated prone-8 mice compared with senescence-resistant-1 mice. ( Deng, Y; He, Z; Lu, B; Qi, B; Su, D; Tian, J; Wang, X; Xu, H; Zheng, B, 2014)
"Sevoflurane MAC was not significantly reduced by N2O and its antinociceptive action was almost completely abolished in KOP-knockout (KO) mice."1.40κ-Opioid receptor mediates the antinociceptive effect of nitrous oxide in mice. ( Fukagawa, H; Fukuda, K; Koyama, T, 2014)
"Lidocaine was injected percutaneously at the sciatic nerve in volumes of 0."1.32The critical role of concentration for lidocaine block of peripheral nerve in vivo: studies of function and drug uptake in the rat. ( Birknes, J; Nakamura, T; Popitz-Bergez, F; Strichartz, GR, 2003)

Research

Studies (58)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (12.07)18.2507
2000's18 (31.03)29.6817
2010's23 (39.66)24.3611
2020's10 (17.24)2.80

Authors

AuthorsStudies
Selva-Sevilla, C2
Fernández-Ginés, FD3
Cortiñas-Sáenz, M4
Gerónimo-Pardo, M3
Liang, X1
Chen, P1
Chen, C1
Che, W1
Yang, Y1
Tan, Z1
Li, H1
Zhou, Y1
Yin, S1
To, MK1
Niu, Q1
Estephan, LE2
Sussman, S1
Stewart, M1
Zhan, T1
Thaler, A1
Boon, M1
Hunt, P1
Huntley, C1
Sagalow, ES1
Kumar, AT1
Hwang, M1
Krein, H1
Heffelfinger, R1
Zhou, F1
Cui, Y1
Cao, L1
Mo, X1
Zeng, J1
Wu, X1
Huang, F1
Zhang, K1
Agudo-Ponce, D1
Navajas-Gómez de Aranda, A1
Morales-Molina, JA2
Fernández-Sánchez, C2
Sierra-García, F2
Mateo-Carrasco, H2
Zhang, JW1
Lv, ZG1
Zhang, WW1
Wang, Z1
Wang, BG1
Zhang, J1
Lv, Z1
Bai, L1
Wang, B1
Yan, C1
Ti-Jun, D1
Xin, L1
Gao, C1
Shen, J1
Hong, T1
Zhi-Xiu, M1
Dámaso Fernández-Ginés, F1
de Aranda, AN1
Navarro-Muñoz, E1
Rodríguez-Carmona, R1
Imbernon-Moya, A2
Ortiz-de Frutos, FJ1
Sanjuan-Alvarez, M2
Portero-Sanchez, I2
Merinero-Palomares, R1
Alcazar, V1
Ryu, K1
Song, K1
Kim, J1
Kim, E1
Kim, SH1
Frutos, JO1
Gomez, F1
Cabrera, M1
Sanabria, P1
Sanchez, L1
Lopez-Ortego, P1
Elorza, MD1
Martínez-Monsalve, A1
Passariello, M1
Almenrader, N1
Casado, R1
Lumbreras, J1
de Inocencio, J1
Remesal, A1
Merino, R1
García-Consuegra, J1
Xu, H1
Lu, B1
Zheng, B1
Tian, J1
Qi, B1
Deng, Y1
He, Z1
Su, D1
Wang, X1
Fukagawa, H1
Koyama, T1
Fukuda, K1
Wang, LW1
Zhou, MY1
Jian, HW1
Dai, TJ5
Chen, JQ1
Zeng, YM4
Tang, QF1
Luo, C1
Zhang, YL1
Luo, W1
Zhou, FH1
Li, CQ1
Xu, JM1
Dai, RP1
Kim, HC1
Hong, WP1
Lim, YJ1
Park, HP1
Smith, I1
Walley, G1
Bridgman, S1
Stevanovic, PD1
Petrova, G1
Miljkovic, B1
Scepanovic, R1
Perunovic, R1
Stojanovic, D1
Dobrasinovic, J1
Yan, S1
Martuzzi, R1
Ramani, R1
Qiu, M1
Rajeevan, N1
Constable, RT1
Lee, HM2
Lee, DH1
Choi, JH1
Lee, SR1
Kim, YW1
Jee, DL1
DO, HS1
Park, SJ1
Michel, F1
Vialet, R1
Hassid, S1
Nicaise, C1
Garbi, A1
Thomachot, L1
DI Marco, JN1
Lagier, P1
Martin, C1
Park, SH1
Oh, AY1
Goo, EK1
Nahm, FS1
Min, SW1
Hwang, JW1
Kim, CS1
Shin, NR1
Kim, JH1
DeSousa, K1
Ali, MS1
Kil, HK1
Kim, WO1
Chung, WY1
Kim, GH1
Seo, H1
Hong, JY1
Constant, I1
Sabourdin, N1
Untergehrer, G1
Jordan, D1
Eyl, S1
Schneider, G1
Kohase, H1
Miyamoto, T1
Umino, M1
Sumikura, H1
Arendt-Nielsen, L1
Nakamura, T1
Popitz-Bergez, F1
Birknes, J1
Strichartz, GR1
Hagihira, S1
Takashina, M1
Mori, T1
Ueyama, H1
Mashimo, T2
Stekiel, TA1
J Contney, S1
Bosnjak, ZJ1
Kampine, JP1
Roman, RJ1
Stekiel, WJ1
Hepağuşlar, H1
Ozzeybek, D1
Ozkardeşler, S1
Taşdöğen, A1
Duru, S1
Elar, Z1
Garcia-Fernandez, J1
Parodi, E1
Garcia, P1
Matute, E1
A-Gomez-de-Segura, I1
Cediel, R1
Gilsanz, F1
Zeidan, A1
Grover, S1
Wilkinson, DJ1
Chen, Y1
Hang, LH1
Shao, DH1
Yang, YH1
Ihmsen, H1
Schywalsky, M1
Plettke, R1
Priller, M1
Walz, F1
Schwilden, H1
Sandin, M1
Thörn, SE1
Dahlqvist, A1
Wattwil, L1
Axelsson, K1
Wattwil, M1
Eipe, N1
Kay, J1
Tomi, K1
Tashiro, C1
Yagi, M1
Pak, M1
Nishimura, S1
Nishimura, M1
Yoshiya, I1
Sarton, E1
Dahan, A2
Teppema, L2
van den Elsen, M1
Olofsen, E1
Berkenbosch, A1
van Kleef, J1
Hao, S1
Ogawa, H1
Brown, K1
Aun, C1
Stocks, J1
Jackson, E1
Mackersie, A1
Hatch, D1
Shimoda, O1
Ikuta, Y1
Nishi, M1
Uneda, C1
Ma, D1
Chakrabarti, MK1
Whitwam, JG1
Masaki, E1
Ebisawa, T1
Kondo, I1
Hayashida, K1
Matsumoto, Y1
Kawamura, M1

Clinical Trials (9)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Subanesthetic Sevoflurane for Treatment-Resistant Depression: A Proof-of-Concept Trial[NCT05008939]15 participants (Anticipated)Interventional2021-08-31Not yet recruiting
Comparison of the Effects of Sevoflurane and Desflurane on Prevention of Catheter-related Bladder Discomfort[NCT02096224]108 participants (Actual)Interventional2014-05-31Completed
Interest of Using the Sevoflurane in the Prevention of Newborns Pain[NCT00420693]Phase 2/Phase 360 participants (Anticipated)Interventional2006-08-31Completed
The Effect of Preoperative Anxiolysis With Intravenous Midazolam on Intraoperative Sevoflurane Gas Consumption: A Prospective Randomized Controlled Study[NCT05371600]Phase 480 participants (Anticipated)Interventional2022-12-02Recruiting
A Randomized Prospective Placebo-Controlled Study of the Effects of Lavender Aromatherapy on Preoperative Anxiety in Breast Surgery Patients[NCT01837966]93 participants (Actual)Interventional2013-01-31Completed
EEG-based Depth of Anesthesia-monitoring During General Anesthesia - Effects on Time to Wake-up and Post-operative Cognition[NCT04529304]100 participants (Anticipated)Interventional2021-01-08Recruiting
Efficacy of S(+)-Ketamine Administered as a Continuous Infusion for the Control of Postoperative Pain: a Randomized Controlled Trial[NCT02421913]Phase 442 participants (Actual)Interventional2012-06-30Completed
Topical Analgesia Before Inhalational Anaesthesia: A Retrospective Observational Study[NCT04959409]500 participants (Actual)Observational2020-08-01Completed
Efficacy and Safety of Methoxyflurane Vaporized (PENTHROX®) in the Treatment of Acute Trauma Pain in Pre-hospital Setting and in the Emergency Department in Italy: a Multicentre, Randomized, Controlled, Open-label Study[NCT03585374]Phase 3272 participants (Actual)Interventional2018-02-08Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Anxiety Reduction

We hoped to show that lavender aroma therapy reduces preoperative anxiety in patients undergoing breast. The Trait subscale (STAI-TRAID) of the Spielberger State-Trait Anxiety Inventory was administered before and after 10 minutes of aromatherapy treatment pre-surgery. The TRAIT subscale contains 20 questions scored on a Likert scale from 1-4; item scores are summed for a total score ranging from 20 to 80, with higher scores indicating higher anxiety. Change in anxiety was calculated as the score pre-aromatherapy minus the score post-aromatherapy. Higher positive change scores indicate greater reductions in anxiety. (NCT01837966)
Timeframe: 20 minutes before surgery (pre aromatherapy) and 10 minutes before surgery (post aromatherapy)

Interventionunits on a scale (Mean)
Lavender Oil0.89
Placebo.74

Reviews

2 reviews available for sevoflurane and Ache

ArticleYear
Topical sevofluran: a galenic experience.
    Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria, 2021, 07-21, Volume: 45, Issue:5

    Topics: Administration, Topical; Analgesics; Humans; Pain; Quality of Life; Sevoflurane

2021
The EEG signal: a window on the cortical brain activity.
    Paediatric anaesthesia, 2012, Volume: 22, Issue:6

    Topics: Adult; Aging; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Cerebral Cortex; Child;

2012

Trials

13 trials available for sevoflurane and Ache

ArticleYear
Total Intravenous Anesthesia Versus Inhaled Sevoflurane in Obstructive Sleep Apnea Surgery: A Randomized Controlled Trial.
    The Laryngoscope, 2023, Volume: 133, Issue:4

    Topics: Adult; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intraveno

2023
The effect of opioid-free anaesthesia on the quality of recovery after endoscopic sinus surgery: A multicentre randomised controlled trial.
    European journal of anaesthesiology, 2023, 08-01, Volume: 40, Issue:8

    Topics: Analgesics, Opioid; Anesthesia; Humans; Pain; Pain, Postoperative; Postoperative Nausea and Vomiting

2023
Sucking lollipop after awakening from sevoflurane anesthesia reduces the degree of emergence agitation in children undergoing ambulatory surgery: A prospective randomized controlled trial.
    Medicine, 2023, Nov-03, Volume: 102, Issue:44

    Topics: Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhala

2023
Comparison of blood pressure and pain rating index used for depth regulation of sevoflurane anaesthesia.
    JPMA. The Journal of the Pakistan Medical Association, 2021, Volume: 71, Issue:2(B)

    Topics: Anesthesia Recovery Period; Anesthetics, Inhalation; Blood Pressure; Humans; Methyl Ethers; Pain; Se

2021
Comparison of the Analgesic Properties of Sevoflurane and Desflurane Using Surgical Pleth Index at Equi-Minimum Alveolar Concentration.
    International journal of medical sciences, 2017, Volume: 14, Issue:10

    Topics: Adult; Anesthesia, Inhalation; Anesthetics, Inhalation; Arthroscopy; Brachial Plexus Block; Desflura

2017
The effect of sevoflurane versus desflurane on postoperative catheter-related bladder discomfort in patients undergoing transurethral excision of a bladder tumour: a randomized controlled trial.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2016, Volume: 63, Issue:5

    Topics: Aged; Anesthesia, General; Anesthetics, Inhalation; Desflurane; Female; Humans; Incidence; Isofluran

2016
Omitting fentanyl reduces nausea and vomiting, without increasing pain, after sevoflurane for day surgery.
    European journal of anaesthesiology, 2008, Volume: 25, Issue:10

    Topics: Adult; Ambulatory Surgical Procedures; Female; Fentanyl; Humans; Male; Methyl Ethers; Nausea; Pain;

2008
Low fresh gas flow balanced anesthesia versus target controlled intravenous infusion anesthesia in laparoscopic cholecystectomy: a cost-minimization analysis.
    Clinical therapeutics, 2008, Volume: 30, Issue:9

    Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Chol

2008
Sevoflurane for central catheter placement in neonatal intensive care: a randomized trial.
    Paediatric anaesthesia, 2010, Volume: 20, Issue:8

    Topics: Anesthetics, Inhalation; Blood Glucose; Catheterization, Central Venous; Feasibility Studies; Female

2010
A short period of inhalation induction with sevoflurane prevents rocuronium-induced withdrawal in children.
    Acta anaesthesiologica Scandinavica, 2011, Volume: 55, Issue:1

    Topics: Androstanols; Anesthesia, Inhalation; Anesthetics, Inhalation; Blinking; Child; Child, Preschool; Fe

2011
Sevoflurane to alleviate pain on propofol injection.
    Journal of anesthesia, 2011, Volume: 25, Issue:6

    Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Female; Fentanyl; Humans; Injections, Intr

2011
Propofol and sevoflurane during epidural/general anesthesia: comparison of early recovery characteristics and pain relief.
    Middle East journal of anaesthesiology, 2004, Volume: 17, Issue:5

    Topics: Abdomen; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia Recovery Period;

2004
A comparison of the respiratory effects of sevoflurane and halothane in infants and young children.
    Anesthesiology, 1998, Volume: 89, Issue:1

    Topics: Anesthetics, Inhalation; Child, Preschool; Extremities; Halothane; Humans; Infant; Infant, Newborn;

1998

Other Studies

43 other studies available for sevoflurane and Ache

ArticleYear
Cost-effectiveness analysis of domiciliary topical sevoflurane for painful leg ulcers.
    PloS one, 2021, Volume: 16, Issue:9

    Topics: Administration, Topical; Aged; Aged, 80 and over; Analgesics; Bayes Theorem; Cost-Benefit Analysis;

2021
Comprehensive risk assessments and anesthetic management for children with osteogenesis imperfecta: A retrospective review of 252 orthopedic procedures over 5 years.
    Paediatric anaesthesia, 2022, Volume: 32, Issue:7

    Topics: Anesthesia, Conduction; Anesthetics; Child; Hemorrhage; Humans; Orthopedic Procedures; Osteogenesis

2022
Recovery Benefit With Total Intravenous Anesthesia in Patients Receiving Rhinoplasty.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2023, Volume: 169, Issue:3

    Topics: Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; Hum

2023
Pain reduction of topical sevoflurane vs intravenous opioids in pressure ulcers.
    International wound journal, 2020, Volume: 17, Issue:1

    Topics: Administration, Intravenous; Administration, Topical; Adult; Aged; Aged, 80 and over; Analgesics, Op

2020
Correlation between pain rating index and end-tidal sevoflurane concentration during sevoflurane anesthesia.
    The Journal of international medical research, 2021, Volume: 49, Issue:2

    Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Humans; Methyl Ethers; Pain; Partial Pressure;

2021
5-HT1A Receptors Mediate Analgesia Induced by Emulsified Sevoflurane in Thermal Nociception but Have Little Effect on Chemical Nociception.
    Pharmacology, 2017, Volume: 100, Issue:1-2

    Topics: Aminopyridines; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Femal

2017
Efficacy and safety of topical sevoflurane in the treatment of chronic skin ulcers.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2017, May-01, Volume: 74, Issue:9

    Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Anesthetics, Inhalation; Chronic Disease; Female

2017
Healing of chronic venous ulcer with topical sevoflurane.
    International wound journal, 2017, Volume: 14, Issue:6

    Topics: Administration, Topical; Aged; Aged, 80 and over; Chronic Disease; Female; Humans; Male; Methyl Ethe

2017
Application of Topical Sevoflurane Before Cleaning Painful Skin Ulcers.
    Actas dermo-sifiliograficas, 2018, Volume: 109, Issue:5

    Topics: Administration, Topical; Humans; Pain; Sevoflurane; Skin Ulcer

2018
Sevoflurane for Short Painful Procedures in the Neonatal Intensive Care Unit.
    American journal of perinatology, 2019, Volume: 36, Issue:4

    Topics: Anesthetics, Inhalation; Biopsy; Catheterization, Central Venous; Gestational Age; Humans; Infant; I

2019
Analgesic effectiveness of topical sevoflurane to perform sharp debridement of painful wounds.
    Journal of vascular surgery, 2019, Volume: 69, Issue:5

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Analgesics; Debridement; Female; Humans; Ma

2019
Anesthesia for a child with Camurati-Engelmann disease.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:5

    Topics: Anesthesia, General; Anesthetics, Inhalation; Camurati-Engelmann Syndrome; Child; Colonoscopy; Human

2013
Sedation for intra-articular corticosteroid injections in juvenile idiopathic arthritis: the views of patients and their parents.
    European journal of pediatrics, 2013, Volume: 172, Issue:10

    Topics: Adolescent; Anesthetics, Inhalation; Arthritis, Juvenile; Child; Conscious Sedation; Data Collection

2013
Smaller sized inhaled anesthetics have more potency on senescence-accelerated prone-8 mice compared with senescence-resistant-1 mice.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 39, Issue:1

    Topics: Aging; Alzheimer Disease; Analysis of Variance; Anesthetics, Inhalation; Animals; Desflurane; Diseas

2014
κ-Opioid receptor mediates the antinociceptive effect of nitrous oxide in mice.
    British journal of anaesthesia, 2014, Volume: 113, Issue:6

    Topics: Analgesics, Non-Narcotic; Anesthetics, Inhalation; Animals; Isoflurane; Lumbar Vertebrae; Methyl Eth

2014
Relationship between gamma-hydroxybutyric acid receptors and the hypnotic and analgesic effects of emulsified inhalation anesthetics.
    European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:16

    Topics: Analgesics; Anesthetics, Inhalation; Animals; Benzocycloheptenes; Enflurane; Female; Hot Temperature

2014
Intrathecal L-arginine reduces the antinociception of sevoflurane in formalin-induced pain in rats.
    Neuroscience letters, 2015, Mar-17, Volume: 590

    Topics: Anesthetics, Inhalation; Animals; Arginine; Injections, Spinal; Methyl Ethers; Neurons; Nitric Oxide

2015
Differential effects of general anesthetics on anxiety-like behavior in formalin-induced pain: involvement of ERK activation in the anterior cingulate cortex.
    Psychopharmacology, 2015, Volume: 232, Issue:24

    Topics: Anesthetics, Inhalation; Animals; Anxiety; Behavior, Animal; Extracellular Signal-Regulated MAP Kina

2015
Nicotinic acetylcholine receptors mediate the hypnotic and analgesic effects of emulsified inhalation anesthetics.
    Fundamental & clinical pharmacology, 2009, Volume: 23, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Dose-Response Relationship, Drug; Emulsions; Enflurane; Female; In

2009
Functional connectivity and alterations in baseline brain state in humans.
    NeuroImage, 2010, Jan-01, Volume: 49, Issue:1

    Topics: Adult; Anesthesia; Anesthetics, Inhalation; Brain; Brain Mapping; Female; Humans; Image Processing,

2010
Sevoflurane-induced post-conditioning has no beneficial effects on neuroprotection after incomplete cerebral ischemia in rats.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:3

    Topics: Anesthetics, Inhalation; Animals; Behavior, Animal; Brain Ischemia; Cerebral Cortex; Coloring Agents

2010
Preoperative anxiety and pain sensitivity are independent predictors of propofol and sevoflurane requirements in general anaesthesia.
    British journal of anaesthesia, 2012, Volume: 108, Issue:1

    Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Anxiety; Consciousness Monitors; Cross-Section

2012
Preoperative anxiety and pain sensitivity are independent predictors of propofol and sevoflurane requirements in general anaesthesia.
    British journal of anaesthesia, 2012, Volume: 108, Issue:1

    Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Anxiety; Consciousness Monitors; Cross-Section

2012
Preoperative anxiety and pain sensitivity are independent predictors of propofol and sevoflurane requirements in general anaesthesia.
    British journal of anaesthesia, 2012, Volume: 108, Issue:1

    Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Anxiety; Consciousness Monitors; Cross-Section

2012
Preoperative anxiety and pain sensitivity are independent predictors of propofol and sevoflurane requirements in general anaesthesia.
    British journal of anaesthesia, 2012, Volume: 108, Issue:1

    Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Anxiety; Consciousness Monitors; Cross-Section

2012
Effects of propofol, sevoflurane, remifentanil, and (S)-ketamine in subanesthetic concentrations on visceral and somatosensory pain-evoked potentials.
    Anesthesiology, 2013, Volume: 118, Issue:2

    Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthetics, Intraven

2013
A new method of continuous maxillary nerve block with an indwelling catheter.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2002, Volume: 94, Issue:2

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Lo

2002
MAC reduction after intrathecal coadministration of GABA(A) agonist and glutamate antagonist in rats.
    Journal of anesthesia, 2003, Volume: 17, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Inhalation; Animals; Drug Synergism; Excitatory Amino Acid

2003
The critical role of concentration for lidocaine block of peripheral nerve in vivo: studies of function and drug uptake in the rat.
    Anesthesiology, 2003, Volume: 99, Issue:5

    Topics: Anesthetics, Inhalation; Anesthetics, Local; Animals; Behavior, Animal; Dose-Response Relationship,

2003
Electroencephalographic bicoherence is sensitive to noxious stimuli during isoflurane or sevoflurane anesthesia.
    Anesthesiology, 2004, Volume: 100, Issue:4

    Topics: Adult; Aged; Anesthesia; Anesthetics, Inhalation; Electroencephalography; Female; Fentanyl; Humans;

2004
Reversal of minimum alveolar concentrations of volatile anesthetics by chromosomal substitution.
    Anesthesiology, 2004, Volume: 101, Issue:3

    Topics: Anesthesia, General; Anesthetics, Inhalation; Animals; Chromosomes; Gene Transfer Techniques; Haloth

2004
Clinical actions of subarachnoid sevoflurane administration in vivo: a study in dogs.
    British journal of anaesthesia, 2005, Volume: 95, Issue:4

    Topics: Anesthesia, Spinal; Anesthetics, Inhalation; Animals; Conscious Sedation; Consciousness; Dogs; Dose-

2005
Profound pain due to propofol injection triggered severe bronchospasm in a smoker--A case report.
    Middle East journal of anaesthesiology, 2006, Volume: 18, Issue:5

    Topics: Albuterol; Aminophylline; Anesthetics, Inhalation; Anesthetics, Intravenous; Anti-Inflammatory Agent

2006
Sevoflurane and analgesia.
    British journal of anaesthesia, 2007, Volume: 98, Issue:5

    Topics: Analgesia, Obstetrical; Anesthetics, Inhalation; Female; Humans; Methyl Ethers; Pain; Pregnancy; Sev

2007
Strychnine-sensitive glycine receptors mediate the analgesic but not hypnotic effects of emulsified volatile anesthetics.
    Pharmacology, 2007, Volume: 80, Issue:2-3

    Topics: Analgesia; Anesthetics, Inhalation; Animals; Dose-Response Relationship, Drug; Emulsions; Enflurane;

2007
Spinal alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors may mediate the analgesic effects of emulsified halogenated anaesthetics.
    Clinical and experimental pharmacology & physiology, 2007, Volume: 34, Issue:11

    Topics: Acetic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Anesthetics, Inha

2007
Concentration-effect relations, prediction probabilities (Pk), and signal-to-noise ratios of different electroencephalographic parameters during administration of desflurane, isoflurane, and sevoflurane in rats.
    Anesthesiology, 2008, Volume: 108, Issue:2

    Topics: Animals; Brain; Cross-Over Studies; Desflurane; Electric Stimulation; Electroencephalography; Isoflu

2008
Effects of pain stimulation on bispectral index, heart rate and blood pressure at different minimal alveolar concentration values of sevoflurane.
    Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:3

    Topics: Adult; Anesthesia; Anesthetics, Inhalation; Blood Pressure; Dose-Response Relationship, Drug; Electr

2008
Spontaneously breathing technique for opioid tolerance.
    Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:4

    Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Inhalation; Anti-Inflammatory

2008
Alterations in pain threshold and psychomotor response associated with subanaesthetic concentrations of inhalation anaesthetics in humans.
    British journal of anaesthesia, 1993, Volume: 70, Issue:6

    Topics: Adult; Anesthesia, Inhalation; Anesthetics; Enflurane; Ethers; Halothane; Humans; Isoflurane; Male;

1993
Acute pain and central nervous system arousal do not restore impaired hypoxic ventilatory response during sevoflurane sedation.
    Anesthesiology, 1996, Volume: 85, Issue:2

    Topics: Acute Disease; Administration, Inhalation; Adult; Anesthetics, Inhalation; Arousal; Carbon Dioxide;

1996
Sevoflurane suppresses behavioral response in the rat formalin test: combination with intrathecal lidocaine produced profound suppression of the response.
    Neuroscience letters, 1998, May-29, Volume: 248, Issue:2

    Topics: Anesthetics, Inhalation; Anesthetics, Local; Animals; Behavior, Animal; Drug Synergism; Formaldehyde

1998
Magnitude of skin vasomotor reflex represents the intensity of nociception under general anesthesia.
    Journal of the autonomic nervous system, 1998, Jul-15, Volume: 71, Issue:2-3

    Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Electric Stimulation; Humans; Laser-Doppler Flo

1998
The combined effects of sevoflurane and remifentanil on central respiratory activity and nociceptive cardiovascular responses in anesthetized rabbits.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:2

    Topics: Action Potentials; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Blood Pre

1999
Influence of low-dose anaesthetic agents on ventilatory control: where do we stand?
    British journal of anaesthesia, 1999, Volume: 83, Issue:2

    Topics: Anesthetics, Inhalation; Arousal; Depression, Chemical; Humans; Isoflurane; Methyl Ethers; Pain; Res

1999
P2-purinergic receptor antagonists reduce the minimum alveolar concentration of inhaled volatile anesthetics.
    Brain research, 2000, May-02, Volume: 864, Issue:1

    Topics: Adenosine Triphosphate; Anesthesia; Anesthetics, Inhalation; Animals; Antineoplastic Agents; Brain;

2000