Page last updated: 2024-11-08

serine and Sepsis

serine has been researched along with Sepsis in 9 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

Research Excerpts

ExcerptRelevanceReference
"To investigate the effects of insulin receptor substrate (IRS)-1 and its serine (Ser)(307) phosphorylation and tyrosine (Tyr) phosphorylation on insulin resistance in skeletal muscle cells in the state of sepsis."7.73[Effects of insulin receptor substrate-1 and its serine phosphorylation and tyrosine phosphorylation on insulin resistance in skeletal muscle cells in the state of sepsis: experiment with rats]. ( Li, JS; Li, N; Li, WQ; Wang, XD; Yan, XW, 2006)
" Intraperitoneal injection of D-serine obviously limited the lipopolysaccharide-induced changes, including the impairment of learning and memory, the loss of NMDA receptor subunits, robust neuroinflammation, the levels of ROS stress and the decrease of p-CREB in the hippocampus of mice."3.85Sepsis-induced selective loss of NMDA receptors modulates hippocampal neuropathology in surviving septic mice. ( Ai, S; Le, Y; Ouyang, W; Tong, J; Wang, X; Zhang, S, 2017)
"To investigate the effects of insulin receptor substrate (IRS)-1 and its serine (Ser)(307) phosphorylation and tyrosine (Tyr) phosphorylation on insulin resistance in skeletal muscle cells in the state of sepsis."3.73[Effects of insulin receptor substrate-1 and its serine phosphorylation and tyrosine phosphorylation on insulin resistance in skeletal muscle cells in the state of sepsis: experiment with rats]. ( Li, JS; Li, N; Li, WQ; Wang, XD; Yan, XW, 2006)
" In this study, we demonstrate that sepsis induces insulin resistance and that pretreatment with aspirin inhibits sepsis-induced insulin resistance."3.72Aspirin inhibits serine phosphorylation of IRS-1 in muscle and adipose tissue of septic rats. ( Barreiro, GC; Caliseo, CT; Carvalheira, JB; Fugiwara, FY; Prada, PO; Prattali, RR; Saad, MJ; Ueno, M; Velloso, LA, 2004)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19901 (11.11)18.7374
1990's0 (0.00)18.2507
2000's3 (33.33)29.6817
2010's5 (55.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhang, S1
Wang, X1
Ai, S1
Ouyang, W1
Le, Y1
Tong, J1
Rodriguez, AE1
Ducker, GS1
Billingham, LK1
Martinez, CA1
Mainolfi, N1
Suri, V1
Friedman, A1
Manfredi, MG1
Weinberg, SE1
Rabinowitz, JD1
Chandel, NS1
Kwok, W1
Clemens, MG1
Wang, GQ1
Tang, T1
Wang, ZS1
Liu, YY1
Wang, L1
Luo, PF1
Xia, ZF1
Gao, JP1
Huang, M1
Li, N2
Wang, PF1
Chen, HL1
Xu, QP1
Barreiro, GC1
Prattali, RR1
Caliseo, CT1
Fugiwara, FY1
Ueno, M1
Prada, PO1
Velloso, LA1
Saad, MJ1
Carvalheira, JB1
Finigan, JH1
Dudek, SM1
Singleton, PA1
Chiang, ET1
Jacobson, JR1
Camp, SM1
Ye, SQ1
Garcia, JG1
Yan, XW1
Li, WQ1
Wang, XD1
Li, JS1
Aumont, P1
Enard, C1
Expert, D1
Pieddeloup, C1
Tancrède, C1
Andremont, A1

Other Studies

9 other studies available for serine and Sepsis

ArticleYear
Sepsis-induced selective loss of NMDA receptors modulates hippocampal neuropathology in surviving septic mice.
    PloS one, 2017, Volume: 12, Issue:11

    Topics: Animals; Cyclic AMP Response Element-Binding Protein; Hippocampus; Inflammation; Lipopolysaccharides

2017
Serine Metabolism Supports Macrophage IL-1β Production.
    Cell metabolism, 2019, 04-02, Volume: 29, Issue:4

    Topics: Animals; Cells, Cultured; Disease Models, Animal; Female; Interleukin-1beta; Lipopolysaccharides; Ma

2019
Rho-kinase activation contributes to Lps-induced impairment of endothelial nitric oxide synthase activation by endothelin-1 in cultured hepatic sinusoidal endothelial cells.
    Shock (Augusta, Ga.), 2014, Volume: 42, Issue:6

    Topics: Actins; Amides; Animals; Caveolin 1; Cells, Cultured; Cofilin 1; Endothelial Cells; Endothelin-1; En

2014
Overexpression of Hypo-Phosphorylated IκBβ at Ser313 Protects the Heart against Sepsis.
    PloS one, 2016, Volume: 11, Issue:8

    Topics: Animals; Apoptosis; Autophagy; Cathepsin L; Cytokines; Gene Expression; Heart; I-kappa B Proteins; M

2016
Efficacy of a novel endotoxin adsorber polyvinylidene fluoride fiber immobilized with (L)-serine ligand on septic pigs.
    Journal of Zhejiang University. Science. B, 2011, Volume: 12, Issue:4

    Topics: Adsorption; Animals; Endotoxins; Hemoperfusion; Interleukin-6; Ligands; Lipopolysaccharides; Male; O

2011
Aspirin inhibits serine phosphorylation of IRS-1 in muscle and adipose tissue of septic rats.
    Biochemical and biophysical research communications, 2004, Jul-30, Volume: 320, Issue:3

    Topics: Adipose Tissue; Animals; Aspirin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mus

2004
Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation.
    The Journal of biological chemistry, 2005, Apr-29, Volume: 280, Issue:17

    Topics: Actins; Blood Coagulation Factors; Cells, Cultured; Cytoskeleton; Dose-Response Relationship, Drug;

2005
[Effects of insulin receptor substrate-1 and its serine phosphorylation and tyrosine phosphorylation on insulin resistance in skeletal muscle cells in the state of sepsis: experiment with rats].
    Zhonghua yi xue za zhi, 2006, Nov-07, Volume: 86, Issue:41

    Topics: Adaptor Proteins, Signal Transducing; Animals; Blood Glucose; Insulin Receptor Substrate Proteins; I

2006
Production of haemolysin, aerobactin and enterobactin by strains of Escherichia coli causing bacteraemia in cancer patients, and their resistance to human serum.
    Research in microbiology, 1989, Volume: 140, Issue:1

    Topics: Antibodies, Bacterial; Enterobactin; Escherichia coli; Hemolysin Proteins; Hydroxamic Acids; Neoplas

1989