serine has been researched along with Heart Failure in 30 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This Controversies in Research article discusses the hypothesis that protein kinase A (PKA)-mediated phosphorylation of the Ryanodine Receptor (RyR) at a single serine (RyRS2808) is essential for normal sympathetic regulation of cardiac myocyte contractility and is responsible for the disturbed Ca(2+) regulation that underlies depressed contractility in heart failure." | 8.90 | Role of RyR2 phosphorylation in heart failure and arrhythmias: protein kinase A-mediated hyperphosphorylation of the ryanodine receptor at serine 2808 does not alter cardiac contractility or cause heart failure and arrhythmias. ( Houser, SR, 2014) |
| "Hyperphosphorylation of the cardiac Ca2+ release channel (ryanodine receptor, RyR2) by protein kinase A (PKA) at serine-2808 has been proposed to be a key mechanism responsible for cardiac dysfunction in heart failure (HF)." | 7.73 | Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure. ( Chen, SR; Cheng, H; Jiang, MT; Lai, FA; Sutherland, C; Walsh, MP; Warltier, DC; Xiao, B; Yang, D; Zhao, M, 2005) |
| "The role of phosphorylation of the ryanodine receptor at serine-2808 (RyRS2808) in congestive heart failure (CHF) is controversial, and effects of RyRS2808 phosphorylation on contraction are unclear." | 7.73 | Spontaneous diastolic contractions and phosphorylation of the cardiac ryanodine receptor at serine-2808 in congestive heart failure in rat. ( Chen, SR; Davidoff, AW; Mei, J; Obayashi, M; Stuyvers, BD; ter Keurs, HE; Xiao, B, 2006) |
| "This Controversies in Research article discusses the hypothesis that protein kinase A (PKA)-mediated phosphorylation of the Ryanodine Receptor (RyR) at a single serine (RyRS2808) is essential for normal sympathetic regulation of cardiac myocyte contractility and is responsible for the disturbed Ca(2+) regulation that underlies depressed contractility in heart failure." | 4.90 | Role of RyR2 phosphorylation in heart failure and arrhythmias: protein kinase A-mediated hyperphosphorylation of the ryanodine receptor at serine 2808 does not alter cardiac contractility or cause heart failure and arrhythmias. ( Houser, SR, 2014) |
| "In human heart failure, Ser199 (equivalent to Ser200 in mouse) of cTnI (cardiac troponin I) is significantly hyperphosphorylated, and in vitro studies suggest that it enhances myofilament calcium sensitivity and alters calpain-mediated cTnI proteolysis." | 3.85 | Heart Failure-Related Hyperphosphorylation in the Cardiac Troponin I C Terminus Has Divergent Effects on Cardiac Function In Vivo. ( Heravi, A; Kass, DA; Keceli, G; Li, Y; Murphy, AM; Okumus, N; Paolocci, N; Ramirez-Correa, G; Takahashi, C; Zhang, P; Zhu, G, 2017) |
| "Phosphorylation of the cardiac ryanodine receptor (RyR2) is thought to be important not only for normal cardiac excitation-contraction coupling but also in exacerbating abnormalities in Ca²+ homeostasis in heart failure." | 3.77 | Ca²+-dependent phosphorylation of RyR2 can uncouple channel gating from direct cytosolic Ca²+ regulation. ( Carter, S; Colyer, J; Pitt, SJ; Sitsapesan, R, 2011) |
| "Phosphorylation and translocation of serine 722 and serine 910 of phosphorylated FAK play an important role in the de-compensatory cardiac hypertrophy." | 3.74 | [Phosphorylation and nuclear translocation of serine 722 and serine 910 of focal adhesion kinase in hypertrophic cardiac myocytes of left ventricle of spontaneously hypertensive rats]. ( Faqian, L; Li, ZY; Yi, XP; Zhong, L, 2008) |
| "Hyperphosphorylation of the cardiac Ca2+ release channel (ryanodine receptor, RyR2) by protein kinase A (PKA) at serine-2808 has been proposed to be a key mechanism responsible for cardiac dysfunction in heart failure (HF)." | 3.73 | Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure. ( Chen, SR; Cheng, H; Jiang, MT; Lai, FA; Sutherland, C; Walsh, MP; Warltier, DC; Xiao, B; Yang, D; Zhao, M, 2005) |
| "The role of phosphorylation of the ryanodine receptor at serine-2808 (RyRS2808) in congestive heart failure (CHF) is controversial, and effects of RyRS2808 phosphorylation on contraction are unclear." | 3.73 | Spontaneous diastolic contractions and phosphorylation of the cardiac ryanodine receptor at serine-2808 in congestive heart failure in rat. ( Chen, SR; Davidoff, AW; Mei, J; Obayashi, M; Stuyvers, BD; ter Keurs, HE; Xiao, B, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (40.00) | 29.6817 |
| 2010's | 15 (50.00) | 24.3611 |
| 2020's | 2 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, T | 1 |
| Wang, R | 1 |
| Zhang, H | 2 |
| Zhao, F | 1 |
| Nougué, H | 1 |
| Michel, T | 1 |
| Picard, F | 1 |
| Lassus, J | 1 |
| Sadoune, M | 1 |
| Laribi, S | 1 |
| Cohen-Solal, A | 1 |
| Logeart, D | 1 |
| Launay, JM | 1 |
| Vodovar, N | 1 |
| Li, Y | 2 |
| Zhu, G | 1 |
| Paolocci, N | 1 |
| Zhang, P | 2 |
| Takahashi, C | 1 |
| Okumus, N | 1 |
| Heravi, A | 1 |
| Keceli, G | 1 |
| Ramirez-Correa, G | 1 |
| Kass, DA | 1 |
| Murphy, AM | 2 |
| Sato, PY | 1 |
| Chuprun, JK | 1 |
| Grisanti, LA | 1 |
| Woodall, MC | 1 |
| Brown, BR | 1 |
| Roy, R | 1 |
| Traynham, CJ | 1 |
| Ibetti, J | 1 |
| Lucchese, AM | 1 |
| Yuan, A | 1 |
| Drosatos, K | 1 |
| Tilley, DG | 1 |
| Gao, E | 2 |
| Koch, WJ | 2 |
| Han, YS | 1 |
| Arroyo, J | 1 |
| Ogut, O | 1 |
| Houser, SR | 2 |
| Wijnker, PJ | 1 |
| Sequeira, V | 1 |
| Witjas-Paalberends, ER | 1 |
| Foster, DB | 1 |
| dos Remedios, CG | 1 |
| Stienen, GJ | 1 |
| van der Velden, J | 1 |
| Herren, AW | 1 |
| Weber, DM | 1 |
| Rigor, RR | 1 |
| Margulies, KB | 1 |
| Phinney, BS | 1 |
| Bers, DM | 1 |
| Hafver, TL | 1 |
| Hodne, K | 1 |
| Wanichawan, P | 1 |
| Aronsen, JM | 1 |
| Dalhus, B | 1 |
| Lunde, PK | 1 |
| Lunde, M | 1 |
| Martinsen, M | 1 |
| Enger, UH | 1 |
| Fuller, W | 1 |
| Sjaastad, I | 1 |
| Louch, WE | 1 |
| Sejersted, OM | 1 |
| Carlson, CR | 1 |
| Zhong, L | 1 |
| Yi, XP | 3 |
| Li, ZY | 1 |
| Faqian, L | 1 |
| Currie, S | 1 |
| Qian, J | 1 |
| Ren, X | 1 |
| Wang, X | 3 |
| Jones, WK | 1 |
| Molkentin, JD | 1 |
| Fan, GC | 1 |
| Kranias, EG | 1 |
| Eschenhagen, T | 1 |
| Huynh, QK | 1 |
| Carter, S | 1 |
| Pitt, SJ | 1 |
| Colyer, J | 1 |
| Sitsapesan, R | 1 |
| Kurtz, B | 1 |
| Thibault, HB | 1 |
| Raher, MJ | 1 |
| Popovich, JR | 1 |
| Cawley, S | 1 |
| Atochin, DN | 1 |
| Hayton, S | 1 |
| Shakartzi, HR | 1 |
| Huang, PL | 1 |
| Bloch, KD | 1 |
| Buys, E | 1 |
| Scherrer-Crosbie, M | 1 |
| Chu, M | 1 |
| Iyengar, R | 1 |
| Koshman, YE | 1 |
| Kim, T | 1 |
| Russell, B | 1 |
| Martin, JL | 1 |
| Heroux, AL | 1 |
| Robia, SL | 1 |
| Samarel, AM | 1 |
| Makarewich, CA | 1 |
| Kubo, H | 1 |
| Wang, W | 1 |
| Duran, JM | 1 |
| Berretta, RM | 1 |
| Chen, X | 1 |
| Valdivia, HH | 1 |
| Respress, JL | 1 |
| van Oort, RJ | 1 |
| Li, N | 1 |
| Rolim, N | 1 |
| Dixit, SS | 1 |
| deAlmeida, A | 1 |
| Voigt, N | 1 |
| Lawrence, WS | 1 |
| Skapura, DG | 1 |
| Skårdal, K | 1 |
| Wisløff, U | 1 |
| Wieland, T | 1 |
| Ai, X | 1 |
| Pogwizd, SM | 1 |
| Dobrev, D | 1 |
| Wehrens, XH | 2 |
| Joiner, ML | 1 |
| Koval, OM | 1 |
| Li, J | 1 |
| He, BJ | 1 |
| Allamargot, C | 1 |
| Gao, Z | 1 |
| Luczak, ED | 1 |
| Hall, DD | 1 |
| Fink, BD | 1 |
| Chen, B | 1 |
| Yang, J | 1 |
| Moore, SA | 1 |
| Scholz, TD | 1 |
| Strack, S | 1 |
| Mohler, PJ | 1 |
| Sivitz, WI | 1 |
| Song, LS | 1 |
| Anderson, ME | 1 |
| Gerdes, AM | 2 |
| Li, F | 2 |
| Stange, M | 1 |
| Xu, L | 1 |
| Balshaw, D | 1 |
| Yamaguchi, N | 1 |
| Meissner, G | 1 |
| Cheong, HI | 1 |
| Lee, JW | 1 |
| Zheng, SH | 1 |
| Lee, JH | 1 |
| Kang, JH | 1 |
| Kang, HG | 1 |
| Ha, IS | 1 |
| Lee, SJ | 1 |
| Choi, Y | 1 |
| Xiao, B | 2 |
| Jiang, MT | 1 |
| Zhao, M | 1 |
| Yang, D | 1 |
| Sutherland, C | 1 |
| Lai, FA | 1 |
| Walsh, MP | 1 |
| Warltier, DC | 1 |
| Cheng, H | 1 |
| Chen, SR | 2 |
| Obayashi, M | 1 |
| Stuyvers, BD | 1 |
| Davidoff, AW | 1 |
| Mei, J | 1 |
| ter Keurs, HE | 1 |
| Zhou, J | 1 |
| Huber, L | 1 |
| Qu, J | 1 |
| Messer, AE | 1 |
| Jacques, AM | 1 |
| Marston, SB | 1 |
| Chen-Izu, Y | 1 |
| Ward, CW | 1 |
| Stark, W | 1 |
| Banyasz, T | 1 |
| Sumandea, MP | 1 |
| Balke, CW | 1 |
| Izu, LT | 1 |
| Bridge, JH | 1 |
| Savio-Galimberti, E | 1 |
| Mestyán, J | 1 |
| Fekete, M | 1 |
| Soltész, G | 1 |
| Járai, I | 1 |
| Gáti, I | 1 |
| Preisz, J | 1 |
| Doszpod, J | 1 |
2 reviews available for serine and Heart Failure
| Article | Year |
|---|---|
Role of RyR2 phosphorylation in heart failure and arrhythmias: protein kinase A-mediated hyperphosphorylation of the ryanodine receptor at serine 2808 does not alter cardiac contractility or cause heart failure and arrhythmias.
Topics: Animals; Arrhythmias, Cardiac; Calcium; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal | 2014 |
Cardiac ryanodine receptor phosphorylation by CaM Kinase II: keeping the balance right.
Topics: Amino Acid Sequence; Animals; Arrhythmias, Cardiac; Binding Sites; Calcium-Binding Proteins; Calcium | 2009 |
28 other studies available for serine and Heart Failure
| Article | Year |
|---|---|
Network pharmacology combined with metabolomics reveals the mechanism of Fuzi decoction against chronic heart failure in rats.
Topics: Animals; beta-Alanine; Chronic Disease; Coenzyme A; Diterpenes; Drugs, Chinese Herbal; Glycine; Glyo | 2022 |
Deconvolution of BNP and NT-proBNP Immunoreactivities by Mass Spectrometry in Heart Failure and Sacubitril/Valsartan Treatment.
Topics: Aminobutyrates; Biomarkers; Dyspnea; Heart Failure; Humans; Mass Spectrometry; Natriuretic Peptide, | 2023 |
Heart Failure-Related Hyperphosphorylation in the Cardiac Troponin I C Terminus Has Divergent Effects on Cardiac Function In Vivo.
Topics: Adrenergic beta-Agonists; Animals; Calpain; Disease Models, Animal; Genetic Predisposition to Diseas | 2017 |
Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation.
Topics: Alanine; Animals; Apoptosis; G-Protein-Coupled Receptor Kinase 2; Glucose; Heart Failure; Ischemia; | 2018 |
Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Catalytic Domain; Cyclic AMP; Cyclic AMP-Dependent Protein | 2013 |
Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes.
Topics: Adenosine Triphosphatases; Amino Acid Substitution; Calcium; Cardiomyopathy, Dilated; Cyclic AMP-Dep | 2014 |
CaMKII Phosphorylation of Na(V)1.5: Novel in Vitro Sites Identified by Mass Spectrometry and Reduced S516 Phosphorylation in Human Heart Failure.
Topics: Action Potentials; Amino Acid Sequence; Arrhythmias, Cardiac; Calcium-Calmodulin-Dependent Protein K | 2015 |
Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman.
Topics: Animals; Animals, Newborn; Cells, Cultured; Computational Biology; Disease Models, Animal; Heart Fai | 2016 |
[Phosphorylation and nuclear translocation of serine 722 and serine 910 of focal adhesion kinase in hypertrophic cardiac myocytes of left ventricle of spontaneously hypertensive rats].
Topics: Animals; Cardiomegaly; Cell Nucleus; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinase | 2008 |
Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death.
Topics: Alanine; Animals; Apoptosis; Autophagy; Base Sequence; Disease Models, Animal; Heart Failure; HSP20 | 2009 |
Is ryanodine receptor phosphorylation key to the fight or flight response and heart failure?
Topics: Animals; Calcium; Excitation Contraction Coupling; Heart Failure; Humans; Mice; Mice, Mutant Strains | 2010 |
Evidence for the phosphorylation of serine259 of histone deacetylase 5 by protein kinase Cδ.
Topics: Active Transport, Cell Nucleus; Amino Acid Sequence; Heart Failure; Histone Deacetylases; Humans; In | 2011 |
Ca²+-dependent phosphorylation of RyR2 can uncouple channel gating from direct cytosolic Ca²+ regulation.
Topics: Animals; Calcium; Calcium Channels; Cyclic AMP-Dependent Protein Kinases; Cytosol; Heart Failure; Ho | 2011 |
Nitric oxide synthase 3 deficiency limits adverse ventricular remodeling after pressure overload in insulin resistance.
Topics: Adenosine Triphosphate; Animals; Dietary Fats; Disease Models, Animal; Energy Metabolism; Enzyme Inh | 2011 |
Serine-910 phosphorylation of focal adhesion kinase is critical for sarcomere reorganization in cardiomyocyte hypertrophy.
Topics: Angiotensin II; Animals; Animals, Newborn; Blotting, Western; Cardiomyopathy, Dilated; Cells, Cultur | 2011 |
Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction.
Topics: Animals; Arrhythmias, Cardiac; Calcium; Calcium Channels, L-Type; Cyclic AMP-Dependent Protein Kinas | 2012 |
Role of RyR2 phosphorylation at S2814 during heart failure progression.
Topics: Adult; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomegaly; Cardiomyopathy, Di | 2012 |
CaMKII determines mitochondrial stress responses in heart.
Topics: Animals; Apoptosis; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclosporine; Femal | 2012 |
Subcellular redistribution of focal adhesion kinase and its related nonkinase in hypertrophic myocardium.
Topics: Active Transport, Cell Nucleus; Animals; Cell Membrane; Cell Nucleus; Cytoskeleton; Female; Focal Ad | 2003 |
Characterization of recombinant skeletal muscle (Ser-2843) and cardiac muscle (Ser-2809) ryanodine receptor phosphorylation mutants.
Topics: Amino Acid Substitution; Animals; Cell Line; Electrophysiology; Heart Failure; Humans; Muscle, Skele | 2003 |
Phenotype and genotype of Dent's disease in three Korean boys.
Topics: Arginine; Asian People; Child; Child, Preschool; Chloride Channels; Codon, Nonsense; Diuretics; Furo | 2005 |
Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent P | 2005 |
Spontaneous diastolic contractions and phosphorylation of the cardiac ryanodine receptor at serine-2808 in congestive heart failure in rat.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Diastole; Echocardiography; Heart Fa | 2006 |
Nuclear compartmentalization of FAK and FRNK in cardiac myocytes.
Topics: Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Cell Nucleus; Cell Separation; Chr | 2006 |
Troponin phosphorylation and regulatory function in human heart muscle: dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure.
Topics: Adult; Calcium; Female; Heart Failure; Humans; In Vitro Techniques; Male; Middle Aged; Myocardial Co | 2007 |
Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure.
Topics: Animals; Blotting, Western; Calcium; Cardiomegaly; Computer Simulation; Cyclic AMP-Dependent Protein | 2007 |
What are the consequences of phosphorylation and hyperphosphorylation of ryanodine receptors in normal and failing heart?
Topics: Adrenergic beta-Agonists; Animals; Calcium; Calcium Signaling; Cyclic AMP-Dependent Protein Kinases; | 2008 |
The postnatal changes in the circulating free amino acid pool in the newborn infant. 3. The plasma amino acid ratio in infants born after pregnancies complicated by toxaemia, placental infarction, impaired umbilical circulation and chronic maternal diseas
Topics: Amino Acids; Chronic Disease; Female; Glutamine; Glycine; Heart Defects, Congenital; Heart Failure; | 1971 |