serine has been researched along with Depression in 27 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
Excerpt | Relevance | Reference |
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" We revealed that CSF D-serine concentrations were correlated with depression severity and HVA concentrations and further investigation were required to reveal the effect of medication and disease heterogeneity." | 7.88 | Cerebrospinal fluid D-serine concentrations in major depressive disorder negatively correlate with depression severity. ( Hattori, K; Ishiwata, S; Kunugi, H; Matsumura, R; Miyakawa, T; Nishikawa, T; Sasayama, D; Teraishi, T; Yokota, Y, 2018) |
"We measured the serum levels of d-serine, l-serine, glycine, glutamate and glutamine in patients with depression (n=70), and age-matched healthy subjects (n=78)." | 7.83 | Increased serum levels of serine enantiomers in patients with depression. ( Enohara, M; Fujita, Y; Hasegawa, T; Hashimoto, K; Hashimoto, T; Ishikawa, M; Iyo, M; Kanahara, N; Kimura, A; Nakazato, M; Niitsu, T; Sasaki, T; Shiina, A; Watanabe, H; Yoshida, T, 2016) |
"Depression is associated with immune dysregulation and the aberrant activity of the hypothalamic-pituitary-adrenal (HPA) axis." | 5.56 | Inhibition of JNK ameliorates depressive-like behaviors and reduces the activation of pro-inflammatory cytokines and the phosphorylation of glucocorticoid receptors at serine 246 induced by neuroinflammation. ( Li, Y; Lin, W; Tang, M; Wang, X; Zhang, J; Zhang, K; Zhao, Y, 2020) |
" Furthermore, we investigated the behavioral effects of long-term administration of D-serine added to the drinking water." | 5.39 | Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior. ( Albayram, O; Alferink, J; Barcena de Arellano, ML; Bilkei-Gorzo, A; Imbeault, S; Jeung, H; Otte, DM; Zimmer, A, 2013) |
"D-serine has attracted increasing attention for its possible role in depression." | 4.12 | L-4-Fluorophenylglycine produces antidepressant-like effects and enhances resilience to stress in mice. ( Chan, MH; Chang, WT; Chen, HH; Kuo, TH; Sung, CW, 2022) |
"D-Serine concentration was decreased in depression susceptible mice in NAc." | 4.02 | D-Serine produces antidepressant-like effects in mice through suppression of BDNF signaling pathway and regulation of synaptic adaptations in the nucleus accumbens. ( Chen, Z; Huang, Z; Liu, L; Tang, Z; Wang, W; Yang, Y; Zou, K, 2021) |
" We revealed that CSF D-serine concentrations were correlated with depression severity and HVA concentrations and further investigation were required to reveal the effect of medication and disease heterogeneity." | 3.88 | Cerebrospinal fluid D-serine concentrations in major depressive disorder negatively correlate with depression severity. ( Hattori, K; Ishiwata, S; Kunugi, H; Matsumura, R; Miyakawa, T; Nishikawa, T; Sasayama, D; Teraishi, T; Yokota, Y, 2018) |
"In the present study, the effects of both single (6 mmol L-serine/10 ml/kg orally administrated) and chronic (2% L-serine solution freely given for 28 days) treatments on depression-like behavior were evaluated in Wistar rats, representing the control, and Wistar Kyoto rats, representing an animal model of depression." | 3.85 | Single and chronic L-serine treatments exert antidepressant-like effects in rats possibly by different means. ( Furuse, M; Nagasawa, M; Otsuka, T; Teramoto, S; Togo, Y; Uotsu, N; Yamanaga, M; Yasuo, S; Yoshida, J, 2017) |
"We measured the serum levels of d-serine, l-serine, glycine, glutamate and glutamine in patients with depression (n=70), and age-matched healthy subjects (n=78)." | 3.83 | Increased serum levels of serine enantiomers in patients with depression. ( Enohara, M; Fujita, Y; Hasegawa, T; Hashimoto, K; Hashimoto, T; Ishikawa, M; Iyo, M; Kanahara, N; Kimura, A; Nakazato, M; Niitsu, T; Sasaki, T; Shiina, A; Watanabe, H; Yoshida, T, 2016) |
" In 21 women and 16 men we evaluated PMBC levels of total GR (tGR), GR phosphorylated at serine 211 (pGR-S211) and serine 226 (pGR-S226) and correlated these data with personality traits and current reports of stress, anxiety and depression." | 3.79 | A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults. ( Adzic, M; Djordjevic, J; Jasovic-Gasic, M; Krstic-Demonacos, M; Maric, N; Mihaljevic, M; Mitic, M; Pavlovic, Z; Radojcic, M; Savic, D; Simic, I; Soldatovic, I, 2013) |
"Depression is associated with immune dysregulation and the aberrant activity of the hypothalamic-pituitary-adrenal (HPA) axis." | 1.56 | Inhibition of JNK ameliorates depressive-like behaviors and reduces the activation of pro-inflammatory cytokines and the phosphorylation of glucocorticoid receptors at serine 246 induced by neuroinflammation. ( Li, Y; Lin, W; Tang, M; Wang, X; Zhang, J; Zhang, K; Zhao, Y, 2020) |
" Furthermore, we investigated the behavioral effects of long-term administration of D-serine added to the drinking water." | 1.39 | Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior. ( Albayram, O; Alferink, J; Barcena de Arellano, ML; Bilkei-Gorzo, A; Imbeault, S; Jeung, H; Otte, DM; Zimmer, A, 2013) |
"Depression is usually associated with alterations in the monoaminergic system." | 1.39 | Dysfunctional astrocytic regulation of glutamate transmission in a rat model of depression. ( De Bundel, D; Gómez-Galán, M; Lindskog, M; Smolders, I; Van Eeckhaut, A, 2013) |
"Guanosine is an extracellular signaling molecule implicated in the modulation of glutamatergic transmission and neuroprotection." | 1.38 | Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide-cGMP and PI3K/mTOR pathways. ( Bettio, LE; Budni, J; Colla, AR; Cunha, MP; Oliveira, Á; Pazini, FL; Rodrigues, AL, 2012) |
" After chronic social defeat stress, chronic administration of imipramine significantly improved social interaction in the MeCP2 WT mice." | 1.38 | Phosphorylation of MeCP2 at Ser421 contributes to chronic antidepressant action. ( Cohen, S; Deng, JV; Hutchinson, AN; West, AE, 2012) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (14.81) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (3.70) | 29.6817 |
2010's | 18 (66.67) | 24.3611 |
2020's | 4 (14.81) | 2.80 |
Authors | Studies |
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Chen, Z | 1 |
Tang, Z | 1 |
Zou, K | 1 |
Huang, Z | 1 |
Liu, L | 1 |
Yang, Y | 1 |
Wang, W | 1 |
Sung, CW | 1 |
Chang, WT | 1 |
Chan, MH | 1 |
Kuo, TH | 1 |
Chen, HH | 1 |
Zhang, J | 1 |
Lin, W | 1 |
Tang, M | 1 |
Zhao, Y | 1 |
Zhang, K | 2 |
Wang, X | 1 |
Li, Y | 1 |
Zhao, S | 1 |
Chi, A | 1 |
Yan, J | 1 |
Yao, C | 1 |
Nagasawa, M | 2 |
Otsuka, T | 2 |
Togo, Y | 1 |
Yamanaga, M | 1 |
Yoshida, J | 2 |
Uotsu, N | 1 |
Teramoto, S | 1 |
Yasuo, S | 1 |
Furuse, M | 2 |
Ishiwata, S | 1 |
Hattori, K | 1 |
Sasayama, D | 1 |
Teraishi, T | 1 |
Miyakawa, T | 1 |
Yokota, Y | 1 |
Matsumura, R | 1 |
Nishikawa, T | 1 |
Kunugi, H | 1 |
Wei, IH | 1 |
Chen, KT | 1 |
Tsai, MH | 1 |
Wu, CH | 1 |
Lane, HY | 1 |
Huang, CC | 1 |
Dong, C | 1 |
Zhang, JC | 1 |
Ren, Q | 1 |
Ma, M | 1 |
Qu, Y | 1 |
Yao, W | 1 |
Ishima, T | 1 |
Mori, H | 1 |
Hashimoto, K | 2 |
Sasaki-Hamada, S | 1 |
Nakamura, Y | 1 |
Koizumi, K | 1 |
Nabeta, R | 1 |
Oka, JI | 1 |
Simic, I | 1 |
Adzic, M | 1 |
Maric, N | 1 |
Savic, D | 1 |
Djordjevic, J | 1 |
Mihaljevic, M | 1 |
Mitic, M | 1 |
Pavlovic, Z | 1 |
Soldatovic, I | 1 |
Krstic-Demonacos, M | 1 |
Jasovic-Gasic, M | 1 |
Radojcic, M | 1 |
Ben M'Barek, K | 1 |
Pla, P | 1 |
Orvoen, S | 1 |
Benstaali, C | 1 |
Godin, JD | 1 |
Gardier, AM | 1 |
Saudou, F | 1 |
David, DJ | 1 |
Humbert, S | 1 |
Otte, DM | 1 |
Barcena de Arellano, ML | 1 |
Bilkei-Gorzo, A | 1 |
Albayram, O | 1 |
Imbeault, S | 1 |
Jeung, H | 1 |
Alferink, J | 1 |
Zimmer, A | 1 |
Sun, Y | 1 |
Luo, ZM | 1 |
Zheng, MJ | 1 |
Liu, X | 2 |
Zhong, P | 1 |
Zhang, Z | 1 |
Hu, Y | 1 |
Liu, SJ | 1 |
Lezama-Ruiz, M | 1 |
Joksimovic, M | 1 |
Liu, QS | 1 |
Yoshida, T | 1 |
Ishikawa, M | 1 |
Fujita, Y | 1 |
Niitsu, T | 1 |
Nakazato, M | 1 |
Watanabe, H | 1 |
Sasaki, T | 1 |
Shiina, A | 1 |
Hashimoto, T | 1 |
Kanahara, N | 1 |
Hasegawa, T | 1 |
Enohara, M | 1 |
Kimura, A | 1 |
Iyo, M | 1 |
Wider, C | 1 |
Dachsel, JC | 1 |
Farrer, MJ | 1 |
Dickson, DW | 1 |
Tsuboi, Y | 1 |
Wszolek, ZK | 1 |
Malkesman, O | 1 |
Austin, DR | 1 |
Tragon, T | 1 |
Wang, G | 1 |
Rompala, G | 1 |
Hamidi, AB | 1 |
Cui, Z | 1 |
Young, WS | 1 |
Nakazawa, K | 1 |
Zarate, CA | 1 |
Manji, HK | 1 |
Chen, G | 1 |
Gómez-Galán, M | 1 |
De Bundel, D | 1 |
Van Eeckhaut, A | 1 |
Smolders, I | 1 |
Lindskog, M | 1 |
Ogino, Y | 1 |
Kurata, K | 1 |
Tomonaga, S | 1 |
Bettio, LE | 1 |
Cunha, MP | 1 |
Budni, J | 1 |
Pazini, FL | 1 |
Oliveira, Á | 1 |
Colla, AR | 1 |
Rodrigues, AL | 2 |
Kaster, MP | 1 |
Machado, DG | 1 |
Santos, AR | 1 |
Hutchinson, AN | 1 |
Deng, JV | 1 |
Cohen, S | 1 |
West, AE | 1 |
HEINRICH, K | 1 |
WALTHER-BUEEL, H | 1 |
SORIANO, MV | 1 |
Suzuki, Y | 1 |
Sawamura, K | 1 |
Someya, T | 1 |
Matussek, N | 1 |
Benkert, O | 1 |
Schneider, K | 1 |
Otten, H | 1 |
Pohlmeier, H | 1 |
1 trial available for serine and Depression
Article | Year |
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L-dopa plus decarboxylase inhibitor in depression.
Topics: Carboxy-Lyases; Clinical Trials as Topic; Depression; Dihydroxyphenylalanine; Humans; Hydrazines; Ph | 1970 |
26 other studies available for serine and Depression
Article | Year |
---|---|
D-Serine produces antidepressant-like effects in mice through suppression of BDNF signaling pathway and regulation of synaptic adaptations in the nucleus accumbens.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Chromatography, High Pressure Liq | 2021 |
L-4-Fluorophenylglycine produces antidepressant-like effects and enhances resilience to stress in mice.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amin | 2022 |
Inhibition of JNK ameliorates depressive-like behaviors and reduces the activation of pro-inflammatory cytokines and the phosphorylation of glucocorticoid receptors at serine 246 induced by neuroinflammation.
Topics: Amygdala; Animals; Anthracenes; Brain; Cytokines; Depression; Hippocampus; Hypothalamo-Hypophyseal S | 2020 |
Feature of Heart Rate Variability and Metabolic Mechanism in Female College Students with Depression.
Topics: Adolescent; Autonomic Nervous System; Depression; Fatigue; Female; Glycine; Heart Rate; Humans; Meta | 2020 |
Single and chronic L-serine treatments exert antidepressant-like effects in rats possibly by different means.
Topics: Administration, Oral; Animals; Antidepressive Agents; Behavior, Animal; Cystathionine; Depression; D | 2017 |
Cerebrospinal fluid D-serine concentrations in major depressive disorder negatively correlate with depression severity.
Topics: Adult; Chromatography, High Pressure Liquid; Depression; Depressive Disorder, Major; Female; Humans; | 2018 |
Acute Amino Acid d-Serine Administration, Similar to Ketamine, Produces Antidepressant-like Effects through Identical Mechanisms.
Topics: Animals; Antidepressive Agents; Apoptosis; Brain; Brain-Derived Neurotrophic Factor; Cyclic AMP-Depe | 2017 |
Deletion of serine racemase confers D-serine -dependent resilience to chronic social defeat stress.
Topics: Animals; Brain-Derived Neurotrophic Factor; Depression; Depressive Disorder; Disease Models, Animal; | 2018 |
Pharmacological evidence for the relationship between the NMDA receptor and nitric oxide pathway and the antidepressant-like effects of glucagon-like peptide-2 in the mouse forced-swim test.
Topics: Animals; Antidepressive Agents; Arginine; Cyclic GMP; Depression; Dizocilpine Maleate; Glucagon-Like | 2019 |
A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults.
Topics: Adult; Chi-Square Distribution; Depression; Female; Humans; Hydrocortisone; Leukocytes, Mononuclear; | 2013 |
Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.
Topics: Analysis of Variance; Animals; Anxiety; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Depres | 2013 |
Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior.
Topics: Animals; Anxiety Disorders; Behavior, Animal; Depression; Disease Models, Animal; Glial Fibrillary A | 2013 |
Phosphatidylethanolamine-binding protein 1 (PEBP1) as a potential target for the treatment for depression.
Topics: Animals; Depression; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Gene Expression | 2013 |
Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors.
Topics: Animals; Antipsychotic Agents; Clozapine; CREB-Binding Protein; Cyclic AMP; Cyclin-Dependent Kinase | 2014 |
Increased serum levels of serine enantiomers in patients with depression.
Topics: Adult; Biomarkers; Case-Control Studies; Depression; Female; Glutamic Acid; Glutamine; Glycine; Huma | 2016 |
Elucidating the genetics and pathology of Perry syndrome.
Topics: Adult; Age of Onset; Aged; Animals; Brain; Chlorocebus aethiops; COS Cells; Depression; DNA-Binding | 2010 |
Acute D-serine treatment produces antidepressant-like effects in rodents.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Calcium-Calmodulin-Dependent Protein Kinase Ty | 2012 |
Dysfunctional astrocytic regulation of glutamate transmission in a rat model of depression.
Topics: Animals; Astrocytes; Depression; Disease Models, Animal; Excitatory Amino Acid Agents; Excitatory Po | 2013 |
Hypothesis with abnormal amino acid metabolism in depression and stress vulnerability in Wistar Kyoto rats.
Topics: Amino Acids; Animals; Behavior, Animal; Biogenic Monoamines; Brain; Cystathionine; Depression; Hypno | 2012 |
Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide-cGMP and PI3K/mTOR pathways.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Arginine; Cyclic GMP; Depression; Disease Mode | 2012 |
Involvement of NMDA receptors in the antidepressant-like action of adenosine.
Topics: Adenosine; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Chlorides; Depression; | 2012 |
Phosphorylation of MeCP2 at Ser421 contributes to chronic antidepressant action.
Topics: Animals; Antidepressive Agents; Depression; Gene Knock-In Techniques; Male; Methyl-CpG-Binding Prote | 2012 |
[Experiences in the treatment of depressive states with 1-seryl-2-isopropylhydrazine].
Topics: Depression; Depressive Disorder; Hydrazines; Oxidoreductases; Serine | 1960 |
[First experiences with serine hydrazide (Ro 4-1038)].
Topics: Anti-Bacterial Agents; Depression; Depressive Disorder; Hydrazines; Oxidoreductases; Serine | 1960 |
[DL-Serine isopropyl hydrazide (Ro4-1038) in depressive syndromes].
Topics: Amino Acids; Anti-Bacterial Agents; Depression; Depressive Disorder; Serine | 1959 |
Polymorphisms in the 5-hydroxytryptamine 2A receptor and CytochromeP4502D6 genes synergistically predict fluvoxamine-induced side effects in japanese depressed patients.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Chi-Square Distribution; Cytochrome P-450 CYP | 2006 |