Page last updated: 2024-11-08

serine and Depression

serine has been researched along with Depression in 27 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
" We revealed that CSF D-serine concentrations were correlated with depression severity and HVA concentrations and further investigation were required to reveal the effect of medication and disease heterogeneity."7.88Cerebrospinal fluid D-serine concentrations in major depressive disorder negatively correlate with depression severity. ( Hattori, K; Ishiwata, S; Kunugi, H; Matsumura, R; Miyakawa, T; Nishikawa, T; Sasayama, D; Teraishi, T; Yokota, Y, 2018)
"We measured the serum levels of d-serine, l-serine, glycine, glutamate and glutamine in patients with depression (n=70), and age-matched healthy subjects (n=78)."7.83Increased serum levels of serine enantiomers in patients with depression. ( Enohara, M; Fujita, Y; Hasegawa, T; Hashimoto, K; Hashimoto, T; Ishikawa, M; Iyo, M; Kanahara, N; Kimura, A; Nakazato, M; Niitsu, T; Sasaki, T; Shiina, A; Watanabe, H; Yoshida, T, 2016)
"Depression is associated with immune dysregulation and the aberrant activity of the hypothalamic-pituitary-adrenal (HPA) axis."5.56Inhibition of JNK ameliorates depressive-like behaviors and reduces the activation of pro-inflammatory cytokines and the phosphorylation of glucocorticoid receptors at serine 246 induced by neuroinflammation. ( Li, Y; Lin, W; Tang, M; Wang, X; Zhang, J; Zhang, K; Zhao, Y, 2020)
" Furthermore, we investigated the behavioral effects of long-term administration of D-serine added to the drinking water."5.39Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior. ( Albayram, O; Alferink, J; Barcena de Arellano, ML; Bilkei-Gorzo, A; Imbeault, S; Jeung, H; Otte, DM; Zimmer, A, 2013)
"D-serine has attracted increasing attention for its possible role in depression."4.12L-4-Fluorophenylglycine produces antidepressant-like effects and enhances resilience to stress in mice. ( Chan, MH; Chang, WT; Chen, HH; Kuo, TH; Sung, CW, 2022)
"D-Serine concentration was decreased in depression susceptible mice in NAc."4.02D-Serine produces antidepressant-like effects in mice through suppression of BDNF signaling pathway and regulation of synaptic adaptations in the nucleus accumbens. ( Chen, Z; Huang, Z; Liu, L; Tang, Z; Wang, W; Yang, Y; Zou, K, 2021)
" We revealed that CSF D-serine concentrations were correlated with depression severity and HVA concentrations and further investigation were required to reveal the effect of medication and disease heterogeneity."3.88Cerebrospinal fluid D-serine concentrations in major depressive disorder negatively correlate with depression severity. ( Hattori, K; Ishiwata, S; Kunugi, H; Matsumura, R; Miyakawa, T; Nishikawa, T; Sasayama, D; Teraishi, T; Yokota, Y, 2018)
"In the present study, the effects of both single (6 mmol L-serine/10 ml/kg orally administrated) and chronic (2% L-serine solution freely given for 28 days) treatments on depression-like behavior were evaluated in Wistar rats, representing the control, and Wistar Kyoto rats, representing an animal model of depression."3.85Single and chronic L-serine treatments exert antidepressant-like effects in rats possibly by different means. ( Furuse, M; Nagasawa, M; Otsuka, T; Teramoto, S; Togo, Y; Uotsu, N; Yamanaga, M; Yasuo, S; Yoshida, J, 2017)
"We measured the serum levels of d-serine, l-serine, glycine, glutamate and glutamine in patients with depression (n=70), and age-matched healthy subjects (n=78)."3.83Increased serum levels of serine enantiomers in patients with depression. ( Enohara, M; Fujita, Y; Hasegawa, T; Hashimoto, K; Hashimoto, T; Ishikawa, M; Iyo, M; Kanahara, N; Kimura, A; Nakazato, M; Niitsu, T; Sasaki, T; Shiina, A; Watanabe, H; Yoshida, T, 2016)
" In 21 women and 16 men we evaluated PMBC levels of total GR (tGR), GR phosphorylated at serine 211 (pGR-S211) and serine 226 (pGR-S226) and correlated these data with personality traits and current reports of stress, anxiety and depression."3.79A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults. ( Adzic, M; Djordjevic, J; Jasovic-Gasic, M; Krstic-Demonacos, M; Maric, N; Mihaljevic, M; Mitic, M; Pavlovic, Z; Radojcic, M; Savic, D; Simic, I; Soldatovic, I, 2013)
"Depression is associated with immune dysregulation and the aberrant activity of the hypothalamic-pituitary-adrenal (HPA) axis."1.56Inhibition of JNK ameliorates depressive-like behaviors and reduces the activation of pro-inflammatory cytokines and the phosphorylation of glucocorticoid receptors at serine 246 induced by neuroinflammation. ( Li, Y; Lin, W; Tang, M; Wang, X; Zhang, J; Zhang, K; Zhao, Y, 2020)
" Furthermore, we investigated the behavioral effects of long-term administration of D-serine added to the drinking water."1.39Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior. ( Albayram, O; Alferink, J; Barcena de Arellano, ML; Bilkei-Gorzo, A; Imbeault, S; Jeung, H; Otte, DM; Zimmer, A, 2013)
"Depression is usually associated with alterations in the monoaminergic system."1.39Dysfunctional astrocytic regulation of glutamate transmission in a rat model of depression. ( De Bundel, D; Gómez-Galán, M; Lindskog, M; Smolders, I; Van Eeckhaut, A, 2013)
"Guanosine is an extracellular signaling molecule implicated in the modulation of glutamatergic transmission and neuroprotection."1.38Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide-cGMP and PI3K/mTOR pathways. ( Bettio, LE; Budni, J; Colla, AR; Cunha, MP; Oliveira, Á; Pazini, FL; Rodrigues, AL, 2012)
" After chronic social defeat stress, chronic administration of imipramine significantly improved social interaction in the MeCP2 WT mice."1.38Phosphorylation of MeCP2 at Ser421 contributes to chronic antidepressant action. ( Cohen, S; Deng, JV; Hutchinson, AN; West, AE, 2012)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19904 (14.81)18.7374
1990's0 (0.00)18.2507
2000's1 (3.70)29.6817
2010's18 (66.67)24.3611
2020's4 (14.81)2.80

Authors

AuthorsStudies
Chen, Z1
Tang, Z1
Zou, K1
Huang, Z1
Liu, L1
Yang, Y1
Wang, W1
Sung, CW1
Chang, WT1
Chan, MH1
Kuo, TH1
Chen, HH1
Zhang, J1
Lin, W1
Tang, M1
Zhao, Y1
Zhang, K2
Wang, X1
Li, Y1
Zhao, S1
Chi, A1
Yan, J1
Yao, C1
Nagasawa, M2
Otsuka, T2
Togo, Y1
Yamanaga, M1
Yoshida, J2
Uotsu, N1
Teramoto, S1
Yasuo, S1
Furuse, M2
Ishiwata, S1
Hattori, K1
Sasayama, D1
Teraishi, T1
Miyakawa, T1
Yokota, Y1
Matsumura, R1
Nishikawa, T1
Kunugi, H1
Wei, IH1
Chen, KT1
Tsai, MH1
Wu, CH1
Lane, HY1
Huang, CC1
Dong, C1
Zhang, JC1
Ren, Q1
Ma, M1
Qu, Y1
Yao, W1
Ishima, T1
Mori, H1
Hashimoto, K2
Sasaki-Hamada, S1
Nakamura, Y1
Koizumi, K1
Nabeta, R1
Oka, JI1
Simic, I1
Adzic, M1
Maric, N1
Savic, D1
Djordjevic, J1
Mihaljevic, M1
Mitic, M1
Pavlovic, Z1
Soldatovic, I1
Krstic-Demonacos, M1
Jasovic-Gasic, M1
Radojcic, M1
Ben M'Barek, K1
Pla, P1
Orvoen, S1
Benstaali, C1
Godin, JD1
Gardier, AM1
Saudou, F1
David, DJ1
Humbert, S1
Otte, DM1
Barcena de Arellano, ML1
Bilkei-Gorzo, A1
Albayram, O1
Imbeault, S1
Jeung, H1
Alferink, J1
Zimmer, A1
Sun, Y1
Luo, ZM1
Zheng, MJ1
Liu, X2
Zhong, P1
Zhang, Z1
Hu, Y1
Liu, SJ1
Lezama-Ruiz, M1
Joksimovic, M1
Liu, QS1
Yoshida, T1
Ishikawa, M1
Fujita, Y1
Niitsu, T1
Nakazato, M1
Watanabe, H1
Sasaki, T1
Shiina, A1
Hashimoto, T1
Kanahara, N1
Hasegawa, T1
Enohara, M1
Kimura, A1
Iyo, M1
Wider, C1
Dachsel, JC1
Farrer, MJ1
Dickson, DW1
Tsuboi, Y1
Wszolek, ZK1
Malkesman, O1
Austin, DR1
Tragon, T1
Wang, G1
Rompala, G1
Hamidi, AB1
Cui, Z1
Young, WS1
Nakazawa, K1
Zarate, CA1
Manji, HK1
Chen, G1
Gómez-Galán, M1
De Bundel, D1
Van Eeckhaut, A1
Smolders, I1
Lindskog, M1
Ogino, Y1
Kurata, K1
Tomonaga, S1
Bettio, LE1
Cunha, MP1
Budni, J1
Pazini, FL1
Oliveira, Á1
Colla, AR1
Rodrigues, AL2
Kaster, MP1
Machado, DG1
Santos, AR1
Hutchinson, AN1
Deng, JV1
Cohen, S1
West, AE1
HEINRICH, K1
WALTHER-BUEEL, H1
SORIANO, MV1
Suzuki, Y1
Sawamura, K1
Someya, T1
Matussek, N1
Benkert, O1
Schneider, K1
Otten, H1
Pohlmeier, H1

Trials

1 trial available for serine and Depression

ArticleYear
L-dopa plus decarboxylase inhibitor in depression.
    Lancet (London, England), 1970, Sep-26, Volume: 2, Issue:7674

    Topics: Carboxy-Lyases; Clinical Trials as Topic; Depression; Dihydroxyphenylalanine; Humans; Hydrazines; Ph

1970

Other Studies

26 other studies available for serine and Depression

ArticleYear
D-Serine produces antidepressant-like effects in mice through suppression of BDNF signaling pathway and regulation of synaptic adaptations in the nucleus accumbens.
    Molecular medicine (Cambridge, Mass.), 2021, 10-15, Volume: 27, Issue:1

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Chromatography, High Pressure Liq

2021
L-4-Fluorophenylglycine produces antidepressant-like effects and enhances resilience to stress in mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 155

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amin

2022
Inhibition of JNK ameliorates depressive-like behaviors and reduces the activation of pro-inflammatory cytokines and the phosphorylation of glucocorticoid receptors at serine 246 induced by neuroinflammation.
    Psychoneuroendocrinology, 2020, Volume: 113

    Topics: Amygdala; Animals; Anthracenes; Brain; Cytokines; Depression; Hippocampus; Hypothalamo-Hypophyseal S

2020
Feature of Heart Rate Variability and Metabolic Mechanism in Female College Students with Depression.
    BioMed research international, 2020, Volume: 2020

    Topics: Adolescent; Autonomic Nervous System; Depression; Fatigue; Female; Glycine; Heart Rate; Humans; Meta

2020
Single and chronic L-serine treatments exert antidepressant-like effects in rats possibly by different means.
    Amino acids, 2017, Volume: 49, Issue:9

    Topics: Administration, Oral; Animals; Antidepressive Agents; Behavior, Animal; Cystathionine; Depression; D

2017
Cerebrospinal fluid D-serine concentrations in major depressive disorder negatively correlate with depression severity.
    Journal of affective disorders, 2018, 01-15, Volume: 226

    Topics: Adult; Chromatography, High Pressure Liquid; Depression; Depressive Disorder, Major; Female; Humans;

2018
Acute Amino Acid d-Serine Administration, Similar to Ketamine, Produces Antidepressant-like Effects through Identical Mechanisms.
    Journal of agricultural and food chemistry, 2017, Dec-13, Volume: 65, Issue:49

    Topics: Animals; Antidepressive Agents; Apoptosis; Brain; Brain-Derived Neurotrophic Factor; Cyclic AMP-Depe

2017
Deletion of serine racemase confers D-serine -dependent resilience to chronic social defeat stress.
    Neurochemistry international, 2018, Volume: 116

    Topics: Animals; Brain-Derived Neurotrophic Factor; Depression; Depressive Disorder; Disease Models, Animal;

2018
Pharmacological evidence for the relationship between the NMDA receptor and nitric oxide pathway and the antidepressant-like effects of glucagon-like peptide-2 in the mouse forced-swim test.
    Behavioural brain research, 2019, 05-17, Volume: 364

    Topics: Animals; Antidepressive Agents; Arginine; Cyclic GMP; Depression; Dizocilpine Maleate; Glucagon-Like

2019
A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults.
    Psychiatry research, 2013, Oct-30, Volume: 209, Issue:3

    Topics: Adult; Chi-Square Distribution; Depression; Female; Humans; Hydrocortisone; Leukocytes, Mononuclear;

2013
Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, May-15, Volume: 33, Issue:20

    Topics: Analysis of Variance; Animals; Anxiety; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Depres

2013
Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Animals; Anxiety Disorders; Behavior, Animal; Depression; Disease Models, Animal; Glial Fibrillary A

2013
Phosphatidylethanolamine-binding protein 1 (PEBP1) as a potential target for the treatment for depression.
    CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:12

    Topics: Animals; Depression; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Gene Expression

2013
Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014, Apr-30, Volume: 34, Issue:18

    Topics: Animals; Antipsychotic Agents; Clozapine; CREB-Binding Protein; Cyclic AMP; Cyclin-Dependent Kinase

2014
Increased serum levels of serine enantiomers in patients with depression.
    Acta neuropsychiatrica, 2016, Volume: 28, Issue:3

    Topics: Adult; Biomarkers; Case-Control Studies; Depression; Female; Glutamic Acid; Glutamine; Glycine; Huma

2016
Elucidating the genetics and pathology of Perry syndrome.
    Journal of the neurological sciences, 2010, Feb-15, Volume: 289, Issue:1-2

    Topics: Adult; Age of Onset; Aged; Animals; Brain; Chlorocebus aethiops; COS Cells; Depression; DNA-Binding

2010
Acute D-serine treatment produces antidepressant-like effects in rodents.
    The international journal of neuropsychopharmacology, 2012, Volume: 15, Issue:8

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Calcium-Calmodulin-Dependent Protein Kinase Ty

2012
Dysfunctional astrocytic regulation of glutamate transmission in a rat model of depression.
    Molecular psychiatry, 2013, Volume: 18, Issue:5

    Topics: Animals; Astrocytes; Depression; Disease Models, Animal; Excitatory Amino Acid Agents; Excitatory Po

2013
Hypothesis with abnormal amino acid metabolism in depression and stress vulnerability in Wistar Kyoto rats.
    Amino acids, 2012, Volume: 43, Issue:5

    Topics: Amino Acids; Animals; Behavior, Animal; Biogenic Monoamines; Brain; Cystathionine; Depression; Hypno

2012
Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide-cGMP and PI3K/mTOR pathways.
    Behavioural brain research, 2012, Oct-01, Volume: 234, Issue:2

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Arginine; Cyclic GMP; Depression; Disease Mode

2012
Involvement of NMDA receptors in the antidepressant-like action of adenosine.
    Pharmacological reports : PR, 2012, Volume: 64, Issue:3

    Topics: Adenosine; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Chlorides; Depression;

2012
Phosphorylation of MeCP2 at Ser421 contributes to chronic antidepressant action.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Oct-10, Volume: 32, Issue:41

    Topics: Animals; Antidepressive Agents; Depression; Gene Knock-In Techniques; Male; Methyl-CpG-Binding Prote

2012
[Experiences in the treatment of depressive states with 1-seryl-2-isopropylhydrazine].
    Psychiatria et neurologia, 1960, Volume: 140

    Topics: Depression; Depressive Disorder; Hydrazines; Oxidoreductases; Serine

1960
[First experiences with serine hydrazide (Ro 4-1038)].
    Psychiatria et neurologia, 1960, Volume: 140

    Topics: Anti-Bacterial Agents; Depression; Depressive Disorder; Hydrazines; Oxidoreductases; Serine

1960
[DL-Serine isopropyl hydrazide (Ro4-1038) in depressive syndromes].
    Revue neurologique, 1959, Volume: 100

    Topics: Amino Acids; Anti-Bacterial Agents; Depression; Depressive Disorder; Serine

1959
Polymorphisms in the 5-hydroxytryptamine 2A receptor and CytochromeP4502D6 genes synergistically predict fluvoxamine-induced side effects in japanese depressed patients.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:4

    Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Chi-Square Distribution; Cytochrome P-450 CYP

2006