serine and Depression
serine has been researched along with Depression in 27 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " We revealed that CSF D-serine concentrations were correlated with depression severity and HVA concentrations and further investigation were required to reveal the effect of medication and disease heterogeneity." | 7.88 | Cerebrospinal fluid D-serine concentrations in major depressive disorder negatively correlate with depression severity. ( Hattori, K; Ishiwata, S; Kunugi, H; Matsumura, R; Miyakawa, T; Nishikawa, T; Sasayama, D; Teraishi, T; Yokota, Y, 2018) |
| "We measured the serum levels of d-serine, l-serine, glycine, glutamate and glutamine in patients with depression (n=70), and age-matched healthy subjects (n=78)." | 7.83 | Increased serum levels of serine enantiomers in patients with depression. ( Enohara, M; Fujita, Y; Hasegawa, T; Hashimoto, K; Hashimoto, T; Ishikawa, M; Iyo, M; Kanahara, N; Kimura, A; Nakazato, M; Niitsu, T; Sasaki, T; Shiina, A; Watanabe, H; Yoshida, T, 2016) |
| "Depression is associated with immune dysregulation and the aberrant activity of the hypothalamic-pituitary-adrenal (HPA) axis." | 5.56 | Inhibition of JNK ameliorates depressive-like behaviors and reduces the activation of pro-inflammatory cytokines and the phosphorylation of glucocorticoid receptors at serine 246 induced by neuroinflammation. ( Li, Y; Lin, W; Tang, M; Wang, X; Zhang, J; Zhang, K; Zhao, Y, 2020) |
| " Furthermore, we investigated the behavioral effects of long-term administration of D-serine added to the drinking water." | 5.39 | Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior. ( Albayram, O; Alferink, J; Barcena de Arellano, ML; Bilkei-Gorzo, A; Imbeault, S; Jeung, H; Otte, DM; Zimmer, A, 2013) |
| "D-serine has attracted increasing attention for its possible role in depression." | 4.12 | L-4-Fluorophenylglycine produces antidepressant-like effects and enhances resilience to stress in mice. ( Chan, MH; Chang, WT; Chen, HH; Kuo, TH; Sung, CW, 2022) |
| "D-Serine concentration was decreased in depression susceptible mice in NAc." | 4.02 | D-Serine produces antidepressant-like effects in mice through suppression of BDNF signaling pathway and regulation of synaptic adaptations in the nucleus accumbens. ( Chen, Z; Huang, Z; Liu, L; Tang, Z; Wang, W; Yang, Y; Zou, K, 2021) |
| " We revealed that CSF D-serine concentrations were correlated with depression severity and HVA concentrations and further investigation were required to reveal the effect of medication and disease heterogeneity." | 3.88 | Cerebrospinal fluid D-serine concentrations in major depressive disorder negatively correlate with depression severity. ( Hattori, K; Ishiwata, S; Kunugi, H; Matsumura, R; Miyakawa, T; Nishikawa, T; Sasayama, D; Teraishi, T; Yokota, Y, 2018) |
| "In the present study, the effects of both single (6 mmol L-serine/10 ml/kg orally administrated) and chronic (2% L-serine solution freely given for 28 days) treatments on depression-like behavior were evaluated in Wistar rats, representing the control, and Wistar Kyoto rats, representing an animal model of depression." | 3.85 | Single and chronic L-serine treatments exert antidepressant-like effects in rats possibly by different means. ( Furuse, M; Nagasawa, M; Otsuka, T; Teramoto, S; Togo, Y; Uotsu, N; Yamanaga, M; Yasuo, S; Yoshida, J, 2017) |
| "We measured the serum levels of d-serine, l-serine, glycine, glutamate and glutamine in patients with depression (n=70), and age-matched healthy subjects (n=78)." | 3.83 | Increased serum levels of serine enantiomers in patients with depression. ( Enohara, M; Fujita, Y; Hasegawa, T; Hashimoto, K; Hashimoto, T; Ishikawa, M; Iyo, M; Kanahara, N; Kimura, A; Nakazato, M; Niitsu, T; Sasaki, T; Shiina, A; Watanabe, H; Yoshida, T, 2016) |
| " In 21 women and 16 men we evaluated PMBC levels of total GR (tGR), GR phosphorylated at serine 211 (pGR-S211) and serine 226 (pGR-S226) and correlated these data with personality traits and current reports of stress, anxiety and depression." | 3.79 | A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults. ( Adzic, M; Djordjevic, J; Jasovic-Gasic, M; Krstic-Demonacos, M; Maric, N; Mihaljevic, M; Mitic, M; Pavlovic, Z; Radojcic, M; Savic, D; Simic, I; Soldatovic, I, 2013) |
| "Depression is associated with immune dysregulation and the aberrant activity of the hypothalamic-pituitary-adrenal (HPA) axis." | 1.56 | Inhibition of JNK ameliorates depressive-like behaviors and reduces the activation of pro-inflammatory cytokines and the phosphorylation of glucocorticoid receptors at serine 246 induced by neuroinflammation. ( Li, Y; Lin, W; Tang, M; Wang, X; Zhang, J; Zhang, K; Zhao, Y, 2020) |
| " Furthermore, we investigated the behavioral effects of long-term administration of D-serine added to the drinking water." | 1.39 | Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior. ( Albayram, O; Alferink, J; Barcena de Arellano, ML; Bilkei-Gorzo, A; Imbeault, S; Jeung, H; Otte, DM; Zimmer, A, 2013) |
| "Depression is usually associated with alterations in the monoaminergic system." | 1.39 | Dysfunctional astrocytic regulation of glutamate transmission in a rat model of depression. ( De Bundel, D; Gómez-Galán, M; Lindskog, M; Smolders, I; Van Eeckhaut, A, 2013) |
| "Guanosine is an extracellular signaling molecule implicated in the modulation of glutamatergic transmission and neuroprotection." | 1.38 | Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide-cGMP and PI3K/mTOR pathways. ( Bettio, LE; Budni, J; Colla, AR; Cunha, MP; Oliveira, Á; Pazini, FL; Rodrigues, AL, 2012) |
| " After chronic social defeat stress, chronic administration of imipramine significantly improved social interaction in the MeCP2 WT mice." | 1.38 | Phosphorylation of MeCP2 at Ser421 contributes to chronic antidepressant action. ( Cohen, S; Deng, JV; Hutchinson, AN; West, AE, 2012) |
Research
Studies (27)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (14.81) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.70) | 29.6817 |
| 2010's | 18 (66.67) | 24.3611 |
| 2020's | 4 (14.81) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Chen, Z | 1 |
| Tang, Z | 1 |
| Zou, K | 1 |
| Huang, Z | 1 |
| Liu, L | 1 |
| Yang, Y | 1 |
| Wang, W | 1 |
| Sung, CW | 1 |
| Chang, WT | 1 |
| Chan, MH | 1 |
| Kuo, TH | 1 |
| Chen, HH | 1 |
| Zhang, J | 1 |
| Lin, W | 1 |
| Tang, M | 1 |
| Zhao, Y | 1 |
| Zhang, K | 2 |
| Wang, X | 1 |
| Li, Y | 1 |
| Zhao, S | 1 |
| Chi, A | 1 |
| Yan, J | 1 |
| Yao, C | 1 |
| Nagasawa, M | 2 |
| Otsuka, T | 2 |
| Togo, Y | 1 |
| Yamanaga, M | 1 |
| Yoshida, J | 2 |
| Uotsu, N | 1 |
| Teramoto, S | 1 |
| Yasuo, S | 1 |
| Furuse, M | 2 |
| Ishiwata, S | 1 |
| Hattori, K | 1 |
| Sasayama, D | 1 |
| Teraishi, T | 1 |
| Miyakawa, T | 1 |
| Yokota, Y | 1 |
| Matsumura, R | 1 |
| Nishikawa, T | 1 |
| Kunugi, H | 1 |
| Wei, IH | 1 |
| Chen, KT | 1 |
| Tsai, MH | 1 |
| Wu, CH | 1 |
| Lane, HY | 1 |
| Huang, CC | 1 |
| Dong, C | 1 |
| Zhang, JC | 1 |
| Ren, Q | 1 |
| Ma, M | 1 |
| Qu, Y | 1 |
| Yao, W | 1 |
| Ishima, T | 1 |
| Mori, H | 1 |
| Hashimoto, K | 2 |
| Sasaki-Hamada, S | 1 |
| Nakamura, Y | 1 |
| Koizumi, K | 1 |
| Nabeta, R | 1 |
| Oka, JI | 1 |
| Simic, I | 1 |
| Adzic, M | 1 |
| Maric, N | 1 |
| Savic, D | 1 |
| Djordjevic, J | 1 |
| Mihaljevic, M | 1 |
| Mitic, M | 1 |
| Pavlovic, Z | 1 |
| Soldatovic, I | 1 |
| Krstic-Demonacos, M | 1 |
| Jasovic-Gasic, M | 1 |
| Radojcic, M | 1 |
| Ben M'Barek, K | 1 |
| Pla, P | 1 |
| Orvoen, S | 1 |
| Benstaali, C | 1 |
| Godin, JD | 1 |
| Gardier, AM | 1 |
| Saudou, F | 1 |
| David, DJ | 1 |
| Humbert, S | 1 |
| Otte, DM | 1 |
| Barcena de Arellano, ML | 1 |
| Bilkei-Gorzo, A | 1 |
| Albayram, O | 1 |
| Imbeault, S | 1 |
| Jeung, H | 1 |
| Alferink, J | 1 |
| Zimmer, A | 1 |
| Sun, Y | 1 |
| Luo, ZM | 1 |
| Zheng, MJ | 1 |
| Liu, X | 2 |
| Zhong, P | 1 |
| Zhang, Z | 1 |
| Hu, Y | 1 |
| Liu, SJ | 1 |
| Lezama-Ruiz, M | 1 |
| Joksimovic, M | 1 |
| Liu, QS | 1 |
| Yoshida, T | 1 |
| Ishikawa, M | 1 |
| Fujita, Y | 1 |
| Niitsu, T | 1 |
| Nakazato, M | 1 |
| Watanabe, H | 1 |
| Sasaki, T | 1 |
| Shiina, A | 1 |
| Hashimoto, T | 1 |
| Kanahara, N | 1 |
| Hasegawa, T | 1 |
| Enohara, M | 1 |
| Kimura, A | 1 |
| Iyo, M | 1 |
| Wider, C | 1 |
| Dachsel, JC | 1 |
| Farrer, MJ | 1 |
| Dickson, DW | 1 |
| Tsuboi, Y | 1 |
| Wszolek, ZK | 1 |
| Malkesman, O | 1 |
| Austin, DR | 1 |
| Tragon, T | 1 |
| Wang, G | 1 |
| Rompala, G | 1 |
| Hamidi, AB | 1 |
| Cui, Z | 1 |
| Young, WS | 1 |
| Nakazawa, K | 1 |
| Zarate, CA | 1 |
| Manji, HK | 1 |
| Chen, G | 1 |
| Gómez-Galán, M | 1 |
| De Bundel, D | 1 |
| Van Eeckhaut, A | 1 |
| Smolders, I | 1 |
| Lindskog, M | 1 |
| Ogino, Y | 1 |
| Kurata, K | 1 |
| Tomonaga, S | 1 |
| Bettio, LE | 1 |
| Cunha, MP | 1 |
| Budni, J | 1 |
| Pazini, FL | 1 |
| Oliveira, Á | 1 |
| Colla, AR | 1 |
| Rodrigues, AL | 2 |
| Kaster, MP | 1 |
| Machado, DG | 1 |
| Santos, AR | 1 |
| Hutchinson, AN | 1 |
| Deng, JV | 1 |
| Cohen, S | 1 |
| West, AE | 1 |
| HEINRICH, K | 1 |
| WALTHER-BUEEL, H | 1 |
| SORIANO, MV | 1 |
| Suzuki, Y | 1 |
| Sawamura, K | 1 |
| Someya, T | 1 |
| Matussek, N | 1 |
| Benkert, O | 1 |
| Schneider, K | 1 |
| Otten, H | 1 |
| Pohlmeier, H | 1 |
Trials
1 trial available for serine and Depression
| Article | Year |
|---|---|
L-dopa plus decarboxylase inhibitor in depression.
Topics: Carboxy-Lyases; Clinical Trials as Topic; Depression; Dihydroxyphenylalanine; Humans; Hydrazines; Ph | 1970 |
Other Studies
26 other studies available for serine and Depression
| Article | Year |
|---|---|
D-Serine produces antidepressant-like effects in mice through suppression of BDNF signaling pathway and regulation of synaptic adaptations in the nucleus accumbens.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Chromatography, High Pressure Liq | 2021 |
L-4-Fluorophenylglycine produces antidepressant-like effects and enhances resilience to stress in mice.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amin | 2022 |
Inhibition of JNK ameliorates depressive-like behaviors and reduces the activation of pro-inflammatory cytokines and the phosphorylation of glucocorticoid receptors at serine 246 induced by neuroinflammation.
Topics: Amygdala; Animals; Anthracenes; Brain; Cytokines; Depression; Hippocampus; Hypothalamo-Hypophyseal S | 2020 |
Feature of Heart Rate Variability and Metabolic Mechanism in Female College Students with Depression.
Topics: Adolescent; Autonomic Nervous System; Depression; Fatigue; Female; Glycine; Heart Rate; Humans; Meta | 2020 |
Single and chronic L-serine treatments exert antidepressant-like effects in rats possibly by different means.
Topics: Administration, Oral; Animals; Antidepressive Agents; Behavior, Animal; Cystathionine; Depression; D | 2017 |
Cerebrospinal fluid D-serine concentrations in major depressive disorder negatively correlate with depression severity.
Topics: Adult; Chromatography, High Pressure Liquid; Depression; Depressive Disorder, Major; Female; Humans; | 2018 |
Acute Amino Acid d-Serine Administration, Similar to Ketamine, Produces Antidepressant-like Effects through Identical Mechanisms.
Topics: Animals; Antidepressive Agents; Apoptosis; Brain; Brain-Derived Neurotrophic Factor; Cyclic AMP-Depe | 2017 |
Deletion of serine racemase confers D-serine -dependent resilience to chronic social defeat stress.
Topics: Animals; Brain-Derived Neurotrophic Factor; Depression; Depressive Disorder; Disease Models, Animal; | 2018 |
Pharmacological evidence for the relationship between the NMDA receptor and nitric oxide pathway and the antidepressant-like effects of glucagon-like peptide-2 in the mouse forced-swim test.
Topics: Animals; Antidepressive Agents; Arginine; Cyclic GMP; Depression; Dizocilpine Maleate; Glucagon-Like | 2019 |
A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults.
Topics: Adult; Chi-Square Distribution; Depression; Female; Humans; Hydrocortisone; Leukocytes, Mononuclear; | 2013 |
Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.
Topics: Analysis of Variance; Animals; Anxiety; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Depres | 2013 |
Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior.
Topics: Animals; Anxiety Disorders; Behavior, Animal; Depression; Disease Models, Animal; Glial Fibrillary A | 2013 |
Phosphatidylethanolamine-binding protein 1 (PEBP1) as a potential target for the treatment for depression.
Topics: Animals; Depression; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Gene Expression | 2013 |
Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors.
Topics: Animals; Antipsychotic Agents; Clozapine; CREB-Binding Protein; Cyclic AMP; Cyclin-Dependent Kinase | 2014 |
Increased serum levels of serine enantiomers in patients with depression.
Topics: Adult; Biomarkers; Case-Control Studies; Depression; Female; Glutamic Acid; Glutamine; Glycine; Huma | 2016 |
Elucidating the genetics and pathology of Perry syndrome.
Topics: Adult; Age of Onset; Aged; Animals; Brain; Chlorocebus aethiops; COS Cells; Depression; DNA-Binding | 2010 |
Acute D-serine treatment produces antidepressant-like effects in rodents.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Calcium-Calmodulin-Dependent Protein Kinase Ty | 2012 |
Dysfunctional astrocytic regulation of glutamate transmission in a rat model of depression.
Topics: Animals; Astrocytes; Depression; Disease Models, Animal; Excitatory Amino Acid Agents; Excitatory Po | 2013 |
Hypothesis with abnormal amino acid metabolism in depression and stress vulnerability in Wistar Kyoto rats.
Topics: Amino Acids; Animals; Behavior, Animal; Biogenic Monoamines; Brain; Cystathionine; Depression; Hypno | 2012 |
Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide-cGMP and PI3K/mTOR pathways.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Arginine; Cyclic GMP; Depression; Disease Mode | 2012 |
Involvement of NMDA receptors in the antidepressant-like action of adenosine.
Topics: Adenosine; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Chlorides; Depression; | 2012 |
Phosphorylation of MeCP2 at Ser421 contributes to chronic antidepressant action.
Topics: Animals; Antidepressive Agents; Depression; Gene Knock-In Techniques; Male; Methyl-CpG-Binding Prote | 2012 |
[Experiences in the treatment of depressive states with 1-seryl-2-isopropylhydrazine].
Topics: Depression; Depressive Disorder; Hydrazines; Oxidoreductases; Serine | 1960 |
[First experiences with serine hydrazide (Ro 4-1038)].
Topics: Anti-Bacterial Agents; Depression; Depressive Disorder; Hydrazines; Oxidoreductases; Serine | 1960 |
[DL-Serine isopropyl hydrazide (Ro4-1038) in depressive syndromes].
Topics: Amino Acids; Anti-Bacterial Agents; Depression; Depressive Disorder; Serine | 1959 |
Polymorphisms in the 5-hydroxytryptamine 2A receptor and CytochromeP4502D6 genes synergistically predict fluvoxamine-induced side effects in japanese depressed patients.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Chi-Square Distribution; Cytochrome P-450 CYP | 2006 |