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safrole and Seizures

safrole has been researched along with Seizures in 2 studies

Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).
safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"Here, we report that seizures and epileptiform activity are reduced by inhibition of the metabolic pathway via lactate dehydrogenase (LDH), a component of the astrocyte-neuron lactate shuttle."1.42Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy. ( Inoue, T; Katsu, T; Lee, S; Otsuki, T; Sada, N, 2015)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Scharfman, HE1
Sada, N1
Lee, S1
Katsu, T1
Otsuki, T1
Inoue, T1

Other Studies

2 other studies available for safrole and Seizures

ArticleYear
Neuroscience. Metabolic control of epilepsy.
    Science (New York, N.Y.), 2015, Mar-20, Volume: 347, Issue:6228

    Topics: Animals; Anticonvulsants; Dioxolanes; Enzyme Inhibitors; L-Lactate Dehydrogenase; Safrole; Seizures

2015
Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy.
    Science (New York, N.Y.), 2015, Mar-20, Volume: 347, Issue:6228

    Topics: Animals; Anticonvulsants; Dioxolanes; Disease Models, Animal; Enzyme Inhibitors; L-Lactate Dehydroge

2015