rolipram and Sepsis
rolipram has been researched along with Sepsis in 7 studies
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| ", acutely restored capillary perfusion in a bell-shaped dose-response effect with 1 mg/kg being the lowest most efficacious dose." | 5.39 | Rolipram improves renal perfusion and function during sepsis in the mouse. ( Gokden, N; Holthoff, JH; Mayeux, PR; Patil, NK; Wang, Z, 2013) |
| "We induced polymicrobial sepsis using the colon ascendens stent peritonitis (CASP) model in which we performed macrohemodynamic and microhemodynamic monitoring with and without systemic intravenous application of different doses of PD-4-I rolipram in Sprague-Dawley rats over 26 h." | 3.80 | Phosphodiesterase 4 inhibition dose dependently stabilizes microvascular barrier functions and microcirculation in a rodent model of polymicrobial sepsis. ( Baar, W; Flemming, S; Germer, CT; Meir, M; Roewer, N; Schick, MA; Schlegel, N; Wollborn, J; Wunder, C, 2014) |
| "Bacteremia-induced sepsis is a leading cause of mortality in intensive care units." | 1.62 | Multifunctional lipid-based nanocarriers with antibacterial and anti-inflammatory activities for treating MRSA bacteremia in mice. ( Alalaiwe, A; Dai, YS; Fang, JY; Liao, CC; Liu, FC; Yang, SC; Yu, HP, 2021) |
| ", acutely restored capillary perfusion in a bell-shaped dose-response effect with 1 mg/kg being the lowest most efficacious dose." | 1.39 | Rolipram improves renal perfusion and function during sepsis in the mouse. ( Gokden, N; Holthoff, JH; Mayeux, PR; Patil, NK; Wang, Z, 2013) |
Research
Studies (7)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Song, G | 1 |
| Zhu, X | 1 |
| Li, J | 1 |
| Hu, D | 1 |
| Zhao, D | 1 |
| Liao, Y | 1 |
| Lin, J | 1 |
| Zhang, LH | 2 |
| Cui, ZN | 2 |
| Hu, DK | 1 |
| Zhao, DS | 1 |
| He, M | 1 |
| Jin, HW | 1 |
| Tang, YM | 1 |
| Song, GP | 1 |
| Liao, CC | 1 |
| Yu, HP | 1 |
| Yang, SC | 1 |
| Alalaiwe, A | 1 |
| Dai, YS | 1 |
| Liu, FC | 1 |
| Fang, JY | 1 |
| Yang, JX | 1 |
| Hsieh, KC | 1 |
| Chen, YL | 1 |
| Lee, CK | 1 |
| Conti, M | 1 |
| Chuang, TH | 1 |
| Wu, CP | 1 |
| Jin, SC | 1 |
| Holthoff, JH | 1 |
| Wang, Z | 1 |
| Patil, NK | 1 |
| Gokden, N | 1 |
| Mayeux, PR | 1 |
| Flemming, S | 1 |
| Schlegel, N | 1 |
| Wunder, C | 1 |
| Meir, M | 1 |
| Baar, W | 1 |
| Wollborn, J | 1 |
| Roewer, N | 1 |
| Germer, CT | 1 |
| Schick, MA | 1 |
| Monneret, G | 1 |
| Arpin, M | 1 |
| Venet, F | 1 |
| Maghni, K | 1 |
| Debard, AL | 1 |
| Pachot, A | 1 |
| Lepape, A | 1 |
| Bienvenu, J | 1 |
Other Studies
7 other studies available for rolipram and Sepsis
| Article | Year |
|---|---|
Rational design of conformationally constrained oxazolidinone-fused 1,2,3,4-tetrahydroisoquinoline derivatives as potential PDE4 inhibitors.
Topics: Animals; Asthma; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Drug Design; | 2017 |
Synthesis and bioactivity of 3,5-dimethylpyrazole derivatives as potential PDE4 inhibitors.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Inhibitory Concentration 50; Mice; Phosphodiesterase | 2018 |
Multifunctional lipid-based nanocarriers with antibacterial and anti-inflammatory activities for treating MRSA bacteremia in mice.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Bacteremia; Ciprofloxacin; Disease Models, | 2021 |
Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages.
Topics: Animals; Cell Survival; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependen | 2017 |
Rolipram improves renal perfusion and function during sepsis in the mouse.
Topics: Acute Kidney Injury; Animals; Blood Flow Velocity; Disease Models, Animal; Glomerular Filtration Rat | 2013 |
Phosphodiesterase 4 inhibition dose dependently stabilizes microvascular barrier functions and microcirculation in a rodent model of polymicrobial sepsis.
Topics: Animals; Coinfection; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium; Hemodyn | 2014 |
Calcitonin gene related peptide and N-procalcitonin modulate CD11b upregulation in lipopolysaccharide activated monocytes and neutrophils.
Topics: Biomarkers; Calcitonin; Calcitonin Gene-Related Peptide; CD11b Antigen; Cells, Cultured; Chemotaxis, | 2003 |