pyrroles has been researched along with Hypoxia in 149 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (2.01) | 18.7374 |
1990's | 36 (24.16) | 18.2507 |
2000's | 18 (12.08) | 29.6817 |
2010's | 70 (46.98) | 24.3611 |
2020's | 22 (14.77) | 2.80 |
Authors | Studies |
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Chapman, RW; Chun, D; Cipolla, D; Corboz, MR; Gauani, H; Li, Z; Malinin, V; Perkins, WR; Plaunt, AJ | 1 |
Bigby, TD; Breen, EC; Cannon, DT; Gilmore, NK; Gutierrez-Gonzalez, AK; Nogueira, L | 1 |
Hidaka, H; Maruyama, J; Maruyama, K; Naito, A; Sakao, S; Sanada, TJ; Shoji, H; Sumi, K; Tatsumi, K; Yoshida, Y; Zhang, E | 1 |
Anderson, SA; Chen, LY; Danner, RL; Dougherty, EJ; Elinoff, JM; Gairhe, S; Johnston, KA; Lu, M; Mazer, AJ; Nelson, JNH; Noguchi, A; Siddique, MAH; Solomon, MA; Solomon, SB; Sun, J; Vanderpool, RR; Wang, H; Wang, S; Yu, ZX; Zou, Y | 1 |
Chen, Z; He, Q; Lin, N; Xie, Q; Yan, F; Yang, B; Ye, S; Yuan, T; Zhang, B; Zhu, H | 1 |
Cheng, Y; Gui, Y; Wu, K; Zhang, Y; Zou, T | 1 |
Cai, Z; Cui, S; Dai, S; Dong, Y; Lin, N; Liu, P; Shi, J; Tong, B; Wu, X | 1 |
Fellinger, TP; Guilherme Buzanich, A; Menga, D; Wagner, F | 1 |
Ghofrani, HA; Grimminger, F; Hadzic, S; Kojonazarov, B; Schermuly, RT; Seeger, W; Weissmann, N | 2 |
Bogaard, HJ; Chaudhary, KR; Hansmann, G; Legchenko, E; Stewart, DJ; Sun, XQ | 1 |
Acoba, MG; Bigham, Z; Claypool, SM; Damarla, M; Huetsch, JC; Jiang, H; Kirsch, BJ; Kliment, C; Le, A; Servinsky, L; Shimoda, LA; Suresh, K; Zaldumbide, J | 1 |
Aliotta, JM; Borgovan, T; Brodsky, AS; Del Tatto, M; Dooner, MS; Goldberg, LR; Klinger, JR; Liang, OD; Pereira, M; Quesenberry, PJ; Ventetuolo, CE; Wen, S; Wu, KQ | 1 |
Ackermann, M; Bogaard, HJ; Chaudhary, KR; Hansmann, G; Jonigk, DD; Kühnel, MP; Legchenko, E; Stewart, DJ; Sun, X | 1 |
Abman, SH; Le Cras, TD | 1 |
Ding, Y; Huang, W; Kong, H; Liu, P; Peng, L; Tan, Q; Wang, H; Wang, J; Wang, Y; Xie, W; Yang, M; Yu, M; Zhou, H | 1 |
Jin, R; Jin, Z; Paudel, O; Sham, JSK; Xia, L; Xia, Y | 1 |
Bogaard, HJ; de Raaf, MA; Schalij, I | 1 |
Fuchikami, C; Honda, Y; Kosugi, K; Kuramoto, K; Kuwano, K; Numakura, Y | 1 |
Adão, R; Bialesova, L; Brás-Silva, C; Kinsella, BT; Mendes-Ferreira, P; Mulvaney, EP; Reid, HM | 1 |
Kikuchi, N; Kurosawa, R; Miyata, S; Nakata, T; Nogi, M; Omura, J; Satoh, K; Satoh, T; Shimokawa, H; Shindo, T; Siddique, MAH; Sunamura, S; Takeuchi, Y | 1 |
Higuchi, T; Inagaki, T; Masaki, T; Nakaoka, Y; Pearson, JT; Saito, S; Schwenke, DO; Shirai, M; Tsuchimochi, H; Umetani, K | 1 |
Kawakami, E; Miwa, H; Naito, A; Sakao, S; Sanada, TJ; Shoji, H; Suda, R; Tanabe, N; Tatsumi, K | 1 |
Banerjee, S; Clark, VR; Fishbein, G; Hong, J; Park, JF; Razee, A; Saddic, L; Umar, S; Williams, T | 1 |
Hata, A; Kato, F; Kobayashi, T; Miwa, H; Nishimura, R; Sakao, S; Sanada, TJ; Shiina, Y; Suzuki, H; Tanabe, N; Tatsumi, K; Voelkel, N; Yoshino, I | 1 |
Awada, C; Bonnet, S; Boucherat, O; Bourgeois, A; Breuils-Bonnet, S; Grobs, Y; Lemay, SE; Nadeau, V; Orcholski, M; Paulin, R; Provencher, S; Romanet, C; Shimauchi, K; Toro, V; Tremblay, E | 1 |
Fujiwara, Y; Hayashi, T; Ijiri, Y; Imano, H; Izumi, Y; Kato, R; Katsumata, T; Okada, Y; Woo, E; Yamaguchi, T; Yoshiyama, M | 1 |
Cha, TL; Chang, SY; Huang, SM; Lai, XM; Liu, SY; Sun, GH; Tsai, YT | 1 |
Kato, F; Nishimura, R; Sakao, S; Suzuki, T; Takeuchi, T; Tanabe, N; Tatsumi, K; Yasuda, T | 1 |
Broccatelli, F; Chen, J; Dragovich, PS; Fan, P; Le, H; Mao, W; Pillow, TH; Polson, AG; Wai, J; Xu, Z; Yao, H; Zhang, D | 1 |
Bigham, Z; Damarla, M; Huetsch, J; Jiang, H; Kliment, C; Servinsky, L; Shimoda, LA; Suresh, K; Yun, X | 1 |
Bansal, A; Bhardwaj, V; Chattopadhyay, P; Nehra, S; Saraswat, D | 1 |
D'Alessandro, A; Dixon, K; Graham, BB; Harral, J; Hernandez-Saavedra, D; Irwin, D; Kassa, B; Koyanagi, D; Kumar, R; Loomis, Z; Mickael, C; Nemkov, T; Perez, M; Sanders, L; Stenmark, KR; Tuder, RM; Valencia, C; Zhang, L | 1 |
Andersen, LMK; Gaustad, JV; Hauge, A; Rofstad, EK; Simonsen, TG; Wegner, CS | 1 |
Chen, D; Chen, G; Gao, P; Jia, D; Jing, ZC; Liu, G; Liu, J; Liu, Q; Lu, A; Qin, Z; Ruan, C; Shen, Y; Tang, J; Wang, XJ; Wang, Y; Ye, J; Yu, Y; Yuan, P; Zhang, J; Zhang, P; Zhou, Y; Zhu, Q; Zuo, C; Zuo, S | 1 |
Bueno-Beti, C; Hadri, L; Hajjar, RJ; Sassi, Y | 1 |
Chaudhary, KR; Deng, Y; Mei, SHJ; Petersen, TH; Stewart, DJ; Suen, CM; Taha, M | 1 |
Vitali, SH | 1 |
Fanburg, BL; Hill, NS; Penumatsa, KC; Warburton, RR | 1 |
Bai, P; Fu, J; He, Y; Jia, D; Lyu, A; Lyu, L; Wan, N; Wan, Q; Yu, T; Zuo, C | 1 |
Chesler, NC; Hacker, TA; Schmuck, EG; Schreier, DA; Wang, Z | 1 |
Carman, BL; Machado, R; Predescu, DN; Predescu, SA | 1 |
Bonini, MG; Castellon, M; Chen, J; Comhair, S; Erzurum, S; Machado, RF; Mao, M; Minshall, RD; Oliveira, SDS; Raj, JU; Silva, CLM | 1 |
Bai, P; Chen, Y; Fu, J; Li, F; Yu, T | 1 |
Al-Mamun, ME; Aoki, J; Doi, T; Kano, K; Kikuchi, H; Kikuchi, N; Kurosawa, R; Matsumoto, Y; Miyata, S; Nogi, M; Numano, K; Omura, J; Oshima, Y; Saigusa, D; Satoh, K; Satoh, T; Shimokawa, H; Siddique, MAH; Sunamura, S; Uruno, A; Yamamoto, M | 1 |
Damarla, M; Damico, RL; Hassoun, PM; Johnston, L; Kolb, TM; Peloquin, GL | 1 |
Baldazza, M; Cachot, S; Faury, G; Fhayli, W; Joyeux-Faure, M; Korichneva, I; Lévy, P; Pépin, JL; Ribuot, C; Totoson, P | 1 |
Albert, FK; Baumgarten, P; Brokinkel, B; Ebel, H; Harter, PN; Hasselblatt, M; Mittelbronn, M; Plate, KH; Stummer, W; Zachskorn, C; Zinke, J | 1 |
Abid, S; Adnot, S; Amsellem, V; Boczkowski, J; Boyer, L; Derumeaux, G; Dubois-Rande, JL; Gary-Bobo, G; Houssaini, A; Marcos, E; Mouraret, N; Saker, M | 1 |
Barrier, M; Biardel, S; Bisserier, M; Bonnet, P; Bonnet, S; Breuils-Bonnet, S; Carter, S; Courchesne, A; Courture, C; Deshaies, Y; Lauzon-Joset, JF; Majka, SM; Meloche, J; Paulin, R; Picard, F; Provencher, S; Racine, C; Tremblay, É | 1 |
Abe, K; Alzoubi, A; Fagan, KA; McMurtry, IF; O'Neill, KD; Oka, M; Rocic, P; Toba, M | 1 |
Cai, S; Fu, Z; Hu, J; Huang, C; Liedtke, W; Paudel, O; Sham, JS; Xia, Y | 1 |
Abraham, D; Baliga, R; Denton, CP; Derrett-Smith, EC; Dooley, A; Gilbane, AJ; Hobbs, AJ; Holmes, AM; Khan, K; Trinder, SL | 1 |
Hoffman, MS; Mitchell, GS | 1 |
Ciuclan, L; Dong, L; Dubois, G; Duggan, N; Edwards, M; England, K; Hussey, M; Jarai, G; Morrell, NW; Sheppard, K; Simmons, J; Sutton, D; Thomas, M; Van Heeke, G | 1 |
Chesler, NC; Eickhoff, JC; Golob, M; Lakes, RS; Wang, Z | 1 |
Abe, K; Alzoubi, A; Gairhe, S; Matsumoto, Y; McMurtry, IF; O'Neill, KD; Oka, M; Oshima, K; Toba, M | 1 |
Chen, P; Dai, L; Wu, S; Zhang, Y; Zhao, S | 1 |
Deng, Y; Guo, X; Liu, H; Shang, J; Yuan, X; Zhu, D | 1 |
Liu, W; Liu, XC; Liu, ZC; Tang, SB; Yu, EH; Zhu, BH | 1 |
Alhussaini, AA; Cool, CD; Farkas, D; Farkas, L; Kraskauskas, D; Kraskauskiene, V; Natarajan, R; Nicolls, MR | 1 |
Bálint, Z; Crnkovic, S; Egemnazarov, B; Gattinger, N; Ghanim, B; Jain, P; Klepetko, W; Kovacs, G; Kwapiszewska, G; Marsh, LM; Olschewski, A; Schermuly, RT; Seay, U; Weissmann, N | 1 |
Bogaard, HJ; de Man, FS; de Raaf, MA; Gomez-Arroyo, J; Happé, C; Rol, N; Schalij, I; Voelkel, NF; Vonk-Noordegraaf, A; Westerhof, N | 1 |
Chesler, NC; Eickhoff, JC; Hacker, TA; Liu, A; Schreier, D; Tian, L; Wang, Z | 1 |
Asmis, R; Barabutis, N; Barman, SA; Black, SM; Catravas, JD; Chen, F; Dimitropoulou, C; Fulton, DJ; Giannis, A; Han, W; Jonigk, D; Keri, G; Orfi, L; Rafikov, R; Rafikova, O; Ramesh, G; Stepp, DW; Su, Y; Szabadkai, I; Szantai-Kis, C; Wang, Y | 1 |
Chi, J; Dong, X; Gu, Q; Ji, R; Jia, X; Leng, X; Li, J; Liu, F; Ma, Y; Sun, B; Sun, R; Zhang, C; Zhang, D; Zhao, X | 1 |
Abbate, A; Bogaard, HJ; Byron, PR; Farkas, L; Gomez-Arroyo, J; Kraskauskas, D; Mizuno, S; Sakagami, M; Syed, AA; Van Tassell, B; Voelkel, NF | 1 |
Chen, J; Chen, XQ; Du, JZ; Evans, AM; Gao, YQ; Hao, K; Kong, FP; Lightman, SL; Tang, JW | 1 |
Chun, HJ; Comhair, SA; Erzurum, SC; Hu, X; Hwangbo, C; Ju, H; Kang, Y; Kim, J; McLean, DL; Mehrotra, D; Papangeli, I; Park, H | 1 |
Abe, K; Fewell, JG; Gerthoffer, WT; Joshi, SR; Matar, M; McLendon, JM; McMurtry, IF; Oka, M; Sparks, J | 1 |
Aitchison, M; Berney, D; Bex, A; Eory, L; Harrison, DJ; Laird, A; Lubbock, AL; Mackay, A; McNeill, SA; Mullen, P; Nanda, J; O'Donnell, M; O'Mahony, FC; Overton, IM; Powles, T; Riddick, AC; Stewart, GD | 1 |
Bijli, KM; Carthan, KA; Green, DE; Hart, CM; Kang, BY; Kleinhenz, JM; Murphy, TC; Park, KK; Searles, CD; Sutliff, RL; Yeligar, SM | 1 |
Gebreab, L; Graham, BB; Huber, KM; Kumar, R; Mickael, C; Perez, M; Sanders, L; Serkova, NJ; Smith-Jones, P; Tuder, RM | 1 |
Chaudhary, KR; Courtman, DW; Deng, Y; Jiang, B; Stewart, DJ; Suen, C; Taha, M | 1 |
Dohi, K; Goto, I; Ito, M; Mitani, Y; Ogihara, Y; Okamoto, R; Yamada, N | 1 |
Huang, QY; Wang, D; Yang, F; Yang, LL; Yuan, GR; Zhou, L | 1 |
Fu, X; Jiang, C; Li, H; Meng, Y; Tang, Y; Yan, F; Yu, L; Zhang, M | 1 |
Chen, G; He, Y; Jia, D; Liu, H; Lu, A; Zhu, Q; Zuo, C | 1 |
Brown, MB; Goodwill, AG; Kline, JA; McCarthy, BP; Neto-Neves, EM; Persohn, SA; Rezania, S; Territo, PR; Zaretskaia, MV | 1 |
Cao, R; Cao, Y; Hauptmann, G; Jensen, LD; Söll, I | 1 |
Angelillo-Scherrer, A; Hirt, L; Price, M; Thevenet, J | 1 |
Abrams, J; Al-Bashir, AK; Haacke, EM; Hillman, GG; Katkuri, Y; Li, M; Patel, AD; Singh-Gupta, V; Yunker, CK; Zhang, H | 1 |
Chang, YC; Huang, CC; Lee, HT; Tu, YF | 1 |
Cascone, T; Heymach, JV; Nilsson, MB; Saigal, B; Wu, HK; Xu, L; Zage, PE; Zeng, L; Zweidler-McKay, PA | 1 |
Campiani, G; Forde, JC; Hollywood, D; Lawler, M; Lynch, TH; Maginn, EN; Marignol, L; Martin, LM; McElligott, AM; McNamara, G; Williams, DC; Zisterer, D | 1 |
Dai, L; Wu, S | 1 |
Ambalavanan, N; Järvinen, TA; Komatsu, M; Mann, D; McMurtry, I; Oka, M; Ruoslahti, E; Sawada, J; Toba, M; Urakami, T | 1 |
Casserly, B; Choudhary, G; Harrington, EO; Klinger, JR; Mazer, JM; Rounds, S; Vang, A | 1 |
Bonneau, O; Ciuclan, L; Duggan, N; Good, R; Holmes, AM; Hussey, M; Jarai, G; Jones, P; Morrell, NW; Stringer, R; Thomas, M; Walker, C; Westwick, J | 1 |
Chiu, CZ; Shyu, KG; Wang, BW | 1 |
Al Hussaini, AA; Allegood, JC; Bogaard, HJ; Fadel, E; Farkas, D; Farkas, L; Guignabert, C; Humbert, M; Kraskauskas, D; Mizuno, S; Ruiter, G; Spiegel, S; Voelkel, NF; Vonk Noordegraaf, A | 1 |
Ghofrani, HA; Grimminger, F; Kalymbetov, A; Kojonazarov, B; Kretschmer, A; Lang, M; Schermuly, RT; Seeger, W; Stasch, JP; Tian, X; Weissmann, N | 1 |
Dahan, D; Ducret, T; Estève, E; Marthan, R; Quignard, JF; Savineau, JP | 1 |
Beach, S; Bonneau, O; Burton, V; Ciuclan, L; Clay, I; Duggan, N; Fox, R; Good, R; Hussey, MJ; Jarai, G; Jones, P; Konstantinova, I; MacLean, MR; Pearce, A; Rowlands, DJ; Thomas, M; Westwick, J | 1 |
Chen, XQ; Du, JZ; Fan, JM; Hao, K; Wang, X; Yuan, Y | 1 |
Abman, SH; Le Cras, TD; Markham, NE; Tuder, RM; Voelkel, NF | 1 |
Gozal, D; Kheirandish, L; Liu, R; Row, BW; Xu, W | 1 |
EDMAN, KA; MONGAR, JL; SCHILD, HO | 1 |
Erber, R; Groth, G; Hammes, HP; Katsen, AD; Kerger, H; Menger, MD; Thurnher, A; Ullrich, A; Vajkoczy, P | 1 |
Fidler, IJ; Yokoi, K | 1 |
Chen, XQ; Du, JZ; Xu, JF | 1 |
Berezin, VA; Bock, E; Dmitrieva, O; Klementiev, B; Lushnikova, IV; Novikova, T; Skibo, GG; Vaudano, E; Voronin, KY | 1 |
Balla, J; Dorosz, J; Dulak, J; Jazwa, A; Jozkowicz, A; Loboda, A; Molema, G | 1 |
Harten, SK; Haskard, DO; Johns, M; Kinderlerer, AR; Lidington, EA; Mason, JC; Maxwell, PH; Steinberg, R | 1 |
Gourgoulianis, KI; Kollia, P; Kostikas, K; Papaioannou, AI | 1 |
Burns, N; Homma, N; Kraskauskas, D; McMurtry, IF; Morris, KG; Oka, M; Taraseviciene-Stewart, L; Voelkel, NF | 1 |
Chen, XQ; Dong, J; Du, JZ; Fan, JM; Niu, CY | 1 |
Earm, YE; Han, J; Jung, ID; Kang, SH; Kim, N; Ko, JH; Park, WS; Park, YM; Son, YK; Warda, M | 1 |
Frøbert, O; Holmager, P; Jensen, KM; Schmidt, EB; Simonsen, U | 1 |
Chen, XQ; Du, JZ; He, JJ; Wang, L; Xu, JF | 1 |
Horwitz, LD; Kuriyama, T; Latham, LP; Sawada, A; Sugita, T; Wagner, WW; Watanabe, S | 1 |
Banta, MR; Dowless, MS; Flavahan, NA; Sylvester, JT; Wiener, CM | 1 |
Ashcroft, FM; Davies, AG; Paterson, DJ; Reid, JM | 1 |
Mellemkjaer, S; Nielsen-Kudsk, JE | 2 |
Gonzalez de la Fuente, P; Marthan, R; Savineau, JP | 1 |
Cyrys, S; Daut, J | 1 |
Guba, K; Nosztray, K; Sz-Körmöczy, P; Szabó, JZ; Szentmiklósi, AJ; Ujfalusi, A; Varga, E | 1 |
Morice, AH; Zhang, F | 1 |
Agata, N; Kato, Y; Shigenobu, K; Tanaka, H | 1 |
Griffith, TM; Randall, MD; Ujiie, H | 1 |
Croxton, TL; Fernandes, LB; Hirshman, CA; Lindeman, KS | 1 |
Boachie-Anash, G; Henderson, CG; Kane, KA; Tweedie, D | 1 |
Kato, S; Kawai, H; Matsuoka, M; Mochizuki, J; Odagawa, A; Shindo, K | 1 |
Griffith, TM; Randall, MD | 1 |
Balderrama, DS; Eichinger, MR; Herrera, GM; Resta, JM; Resta, TC; Richardson, LA; Walker, BR | 1 |
Oda, M; Yamamoto, N; Yamashita, A; Yokota, K; Yoshidomi, M | 1 |
Morice, AH; Woodmansey, PA; Zhang, F | 1 |
O'Brien, E; Wanstall, JC | 1 |
Hara, Y; Masuda, Y; Nakaya, H; Saito, T; Takizawa, T | 1 |
Hüsken, BC; Pfaffendorf, M; van Zwieten, PA | 1 |
Bizub, DM; Gauthier-Rein, KM; Lombard, JH; Rusch, NJ | 1 |
Armstead, WM | 1 |
Barman, SA | 1 |
Andronati, SA; Dyadenko, AI; Korotenko, TI; Mazurov, AA; Shapiro, YE; Sokolenko, NI; Voronina, TA | 1 |
Gozal, D; Gozal, E; Graff, GR; Khicha, SG; Nayak, GS; Simakajornboon, N; Torres, JE | 1 |
Hall, ED; Smith, SL | 1 |
Alger, L; Hirth, P; Kasahara, Y; Mc Mahon , G; Taraseviciene-Stewart, L; Tuder, RM; Voelkel, NF; Waltenberger, J | 1 |
Kozlowski, RZ; Nye, PC; Robertson, BE | 1 |
Akiba, Y; Matsumoto, H; Nakano, H; Onodera, S; Osanai, S; Tobise, K | 1 |
Fernandes, LB; Goldie, RG; Hay, DW; Muccitelli, RM; Page, CP; Preuss, JM; Spina, D | 1 |
Trezise, DJ; Weston, AH | 1 |
Antoine, MH; Herchuelz, A; Lebrun, P | 1 |
Adams, GE; Fielden, EM; Keohane, A; Naylor, MA; O'Neill, P; Stephens, MA; Stratford, IJ; Threadgill, MD; Webb, P | 1 |
Dunn, A; Sylvester, JT; Wiener, CM | 1 |
Armstrong, JM; Gellotte, M; Hicks, PE; Martin, DJ | 1 |
Daut, J; Goedel-Meinen, L; Günther, K; Maier-Rudolph, W; Mehrke, G; von Beckerath, N | 1 |
Blaustein, MP; Rubin, LJ; Tod, ML; Yuan, XJ | 1 |
Sanguinetti, MC; Scott, AL; Siegl, PK; Zingaro, GJ | 1 |
2 review(s) available for pyrroles and Hypoxia
Article | Year |
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Plexiform Arteriopathy in Rodent Models of Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Disease Progression; Humans; Hypoxia; Indoles; MAP Kinase Signaling System; Mice; Mice, Knockout; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats | 2019 |
Clinical implications for vascular endothelial growth factor in the lung: friend or foe?
Topics: Angiogenesis Inhibitors; Angiopoietins; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Ephrins; Humans; Hypoxia; Indoles; Lung; Lung Diseases; Pleural Diseases; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Transcription, Genetic; Vascular Endothelial Growth Factor A | 2006 |
2 trial(s) available for pyrroles and Hypoxia
Article | Year |
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Inactivation of corticotropin-releasing hormone-induced insulinotropic role by high-altitude hypoxia.
Topics: Adenosine Triphosphate; Adolescent; Adult; Altitude; Animals; Blood Glucose; Calcium; Corticosterone; Corticotropin-Releasing Hormone; Cyclic AMP; Humans; Hydrocortisone; Hypoxia; Insulin; Male; Pancreas; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Young Adult | 2015 |
Effect of acute changes in oxygen tension on flow-mediated dilation. Relation to cardivascular risk.
Topics: Administration, Inhalation; Adult; Atorvastatin; Brachial Artery; Cardiovascular Diseases; Cholesterol; Endothelium, Vascular; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Hyperoxia; Hypoxia; Lipoproteins; Male; Middle Aged; Nitroglycerin; Oxygen; Pyrroles; Regional Blood Flow; Research Design; Risk Factors; Treatment Outcome; Triglycerides; Ultrasonography; Vasoconstriction; Vasodilation; Vasodilator Agents | 2008 |
145 other study(ies) available for pyrroles and Hypoxia
Article | Year |
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Treprostinil palmitil inhibits the hemodynamic and histopathological changes in the pulmonary vasculature and heart in an animal model of pulmonary arterial hypertension.
Topics: Administration, Inhalation; Administration, Oral; Animals; Collagen; Disease Models, Animal; Epoprostenol; Heart; Hemodynamics; Hypoxia; Indoles; Male; Myocardium; Phosphodiesterase 5 Inhibitors; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Sildenafil Citrate; Vascular Remodeling; Vasodilator Agents | 2022 |
Role of IL-33 receptor (ST2) deletion in diaphragm contractile and mitochondrial function in the Sugen5416/hypoxia model of pulmonary hypertension.
Topics: Animals; Diaphragm; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Interleukin-1 Receptor-Like 1 Protein; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Mitochondrial Diseases; Muscle Contraction; Protein Kinase Inhibitors; Pulmonary Arterial Hypertension; Pyrroles | 2022 |
The Isoquinoline-Sulfonamide Compound H-1337 Attenuates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension in Rats.
Topics: Animals; Cell Proliferation; Heart Ventricles; Humans; Hypoxia; Indoles; Isoquinolines; Lung; Male; Metabolome; Myosin Light Chains; Phosphorylation; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pyrroles; Rats, Sprague-Dawley; Sulfonamides; TOR Serine-Threonine Kinases; Vascular Remodeling | 2021 |
Mineralocorticoid receptor antagonist treatment of established pulmonary arterial hypertension improves interventricular dependence in the SU5416-hypoxia rat model.
Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Mineralocorticoid Receptor Antagonists; Pulmonary Arterial Hypertension; Pyrroles; Rats; Ventricular Dysfunction, Right | 2022 |
CT-707 overcomes hypoxia-mediated sorafenib resistance in Hepatocellular carcinoma by inhibiting YAP signaling.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Hypoxia; Liver Neoplasms; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Sorafenib; Sulfonamides | 2022 |
Magnetic-targeted capacitive heterostructure of polypyrrole for hypoxia-tolerant synergistic photodynamic/photothermal therapy under near infrared excitation.
Topics: Animals; Cell Line, Tumor; Hydrogen Peroxide; Hypoxia; Magnetic Phenomena; Mice; Mice, Nude; Nanoparticles; Neoplasms; Photochemotherapy; Photosensitizing Agents; Photothermal Therapy; Polymers; Pyrroles; Silicon Dioxide | 2022 |
Constructing Hypoxia-Tolerant and Host Tumor-Enriched Aggregation-Induced Emission Photosensitizer for Suppressing Malignant Tumors Relapse and Metastasis.
Topics: Humans; Hypoxia; Neoplasms; Photochemotherapy; Photosensitizing Agents; Pyrroles; Reactive Oxygen Species; Recurrence | 2022 |
Evaluation of the Specific Activity of M-N-Cs and the Intrinsic Activity of Tetrapyrrolic FeN
Topics: Humans; Hypoxia; Ion Exchange; Iron; Oxygen; Pyrroles | 2022 |
Reply to Bogaard
Topics: Animals; Emphysema; Hypertension, Pulmonary; Hypoxia; Indoles; Phenotype; Pulmonary Arterial Hypertension; Pyrroles; Rats | 2019 |
Emphysema Is-at the Most-Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension.
Topics: Animals; Emphysema; Hypertension, Pulmonary; Hypoxia; Indoles; Phenotype; Pulmonary Arterial Hypertension; Pyrroles; Rats | 2019 |
Regulation of mitochondrial fragmentation in microvascular endothelial cells isolated from the SU5416/hypoxia model of pulmonary arterial hypertension.
Topics: Angiogenesis Inhibitors; Animals; Calcium; Cells, Cultured; Endothelial Cells; Hypoxia; Indoles; Lung; Male; Mitochondria; Oxygen Consumption; Pulmonary Arterial Hypertension; Pyrroles; Rats; Rats, Wistar; Reactive Oxygen Species; Vascular Remodeling | 2019 |
Mesenchymal Stem Cell Extracellular Vesicles Reverse Sugen/Hypoxia Pulmonary Hypertension in Rats.
Topics: Animals; Extracellular Vesicles; Fibroblasts; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Macrophage Activation; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; MicroRNAs; Muscle, Smooth; Neovascularization, Physiologic; Pyrroles; Rats, Sprague-Dawley; Vascular Remodeling; von Willebrand Factor | 2020 |
The Adult Sprague-Dawley Sugen-Hypoxia Rat Is Still "the One:" A Model of Group 1 Pulmonary Hypertension: Reply to Le Cras and Abman.
Topics: Animals; Emphysema; Hypertension, Pulmonary; Hypoxia; Indoles; Pyrroles; Rats; Rats, Sprague-Dawley | 2020 |
Early Disruption of VEGF Receptor Signaling and the Risk for Adult Emphysema.
Topics: Adult; Animals; Emphysema; Hypertension, Pulmonary; Hypoxia; Indoles; Pulmonary Emphysema; Pyrroles; Rats; Receptors, Vascular Endothelial Growth Factor | 2020 |
Paeoniflorin Ameliorates Chronic Hypoxia/SU5416-Induced Pulmonary Arterial Hypertension by Inhibiting Endothelial-to-Mesenchymal Transition.
Topics: Animals; Cells, Cultured; Chronic Disease; Disease Models, Animal; Endothelial Cells; Epithelial-Mesenchymal Transition; Glucosides; Humans; Hypoxia; Indoles; Injections, Subcutaneous; Male; Monoterpenes; Oxygen; Pulmonary Arterial Hypertension; Pyrroles; Rats; Rats, Sprague-Dawley | 2020 |
Cytochrome P450 Epoxygenase-Dependent Activation of TRPV4 Channel Participates in Enhanced Serotonin-Induced Pulmonary Vasoconstriction in Chronic Hypoxic Pulmonary Hypertension.
Topics: Amides; Animals; Chronic Disease; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Eicosanoids; Hypertension, Pulmonary; Hypoxia; Ion Channel Gating; Male; Mice, Inbred C57BL; Morpholines; Pulmonary Artery; Pyrroles; Serotonin; TRPV Cation Channels; Vasoconstriction | 2020 |
The need for hypoxic exposure in experimental PAH - Comment on Chen et al.: a novel rat model of pulmonary hypertension induced by mono treatment with SU5416.
Topics: Animals; Hypertension, Pulmonary; Hypoxia; Indoles; Pyrroles; Rats | 2020 |
The selective PGI2 receptor agonist selexipag ameliorates Sugen 5416/hypoxia-induced pulmonary arterial hypertension in rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetamides; Animals; Cell Proliferation; Collagen Type I; Disease Models, Animal; Heart Ventricles; Hemodynamics; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Lung; Male; Pulmonary Arterial Hypertension; Pyrazines; Pyrroles; Rats, Sprague-Dawley; Receptors, Epoprostenol; Systole; Vascular Remodeling | 2020 |
Efficacy of the thromboxane receptor antagonist NTP42 alone, or in combination with sildenafil, in the sugen/hypoxia-induced model of pulmonary arterial hypertension.
Topics: Angiogenesis Inhibitors; Animals; Drug Therapy, Combination; Hypoxia; Indoles; Male; Pulmonary Arterial Hypertension; Pyrroles; Rats; Rats, Wistar; Receptors, Thromboxane A2, Prostaglandin H2; Sildenafil Citrate; Treatment Outcome; Vasodilator Agents | 2020 |
Identification of Celastrol as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension and Right Ventricular Failure Through Suppression of Bsg (Basigin)/CyPA (Cyclophilin A).
Topics: Animals; Antihypertensive Agents; Basigin; Cyclophilin A; Disease Models, Animal; Humans; Hypoxia; Indoles; Mice; Mice, Transgenic; Myocytes, Cardiac; Pentacyclic Triterpenes; Pulmonary Arterial Hypertension; Pyrroles; Rats; Triterpenes; Ventricular Dysfunction, Right | 2021 |
Evaluation of right coronary vascular dysfunction in severe pulmonary hypertensive rats using synchrotron radiation microangiography.
Topics: Animals; Antihypertensive Agents; Coronary Angiography; Coronary Vessels; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Monocrotaline; Predictive Value of Tests; Pulmonary Arterial Hypertension; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Severity of Illness Index; Sulfonamides; Synchrotrons; Vasodilation; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2021 |
Metabolic remodeling in the right ventricle of rats with severe pulmonary arterial hypertension.
Topics: Animals; Citric Acid Cycle; Fatty Acids; Glucose; Heart Ventricles; Humans; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Oxidation-Reduction; Pulmonary Arterial Hypertension; Pyrroles; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 2021 |
Transcriptomic Analysis of Right Ventricular Remodeling in Two Rat Models of Pulmonary Hypertension: Identification and Validation of Epithelial-to-Mesenchymal Transition in Human Right Ventricular Failure.
Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Animals; Disease Models, Animal; Epithelial-Mesenchymal Transition; Female; Gene Expression Profiling; Heart Failure; Heart Ventricles; Humans; Hypoxia; Indoles; Male; Middle Aged; Monocrotaline; Pulmonary Arterial Hypertension; Pyrroles; Rats; Real-Time Polymerase Chain Reaction; RNA-Seq; Transcriptome; Ventricular Dysfunction, Right; Ventricular Remodeling | 2021 |
Cell Tracking Suggests Pathophysiological and Therapeutic Role of Bone Marrow Cells in Sugen5416/Hypoxia Rat Model of Pulmonary Arterial Hypertension.
Topics: Angiogenesis Inhibitors; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cell Tracking; Disease Models, Animal; Female; Hypoxia; Indoles; Lung; Male; Neointima; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats; Transplantation Chimera; Vascular Remodeling | 2021 |
Preclinical Investigation of Trifluoperazine as a Novel Therapeutic Agent for the Treatment of Pulmonary Arterial Hypertension.
Topics: Animals; Antipsychotic Agents; Cardiovascular Agents; Cell Proliferation; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Repositioning; Female; Forkhead Box Protein O3; Gene Expression Regulation; Hemodynamics; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Survivin; Trifluoperazine | 2021 |
Capillary Degeneration and Right Ventricular Remodeling Due to Hypoxic Stress with Sugen5416.
Topics: Animals; Blood Pressure; Capillaries; Disease Models, Animal; Endothelial Cells; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; In Situ Nick-End Labeling; Indoles; Male; MAP Kinase Signaling System; Myocardium; Myocytes, Cardiac; Oxidative Stress; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; RNA, Messenger; Ventricular Remodeling | 2017 |
HAF mediates the evasive resistance of anti-angiogenesis TKI through disrupting HIF-1α and HIF-2α balance in renal cell carcinoma.
Topics: Angiogenesis Inhibitors; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Renal Cell; Carrier Proteins; Cell Line, Tumor; Cytokines; Endothelial Cells; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Intracellular Signaling Peptides and Proteins; Kidney Neoplasms; Models, Biological; Protein Binding; Protein Kinase Inhibitors; Proteolysis; Pyrroles; Ribonucleoproteins, Small Nuclear; Sunitinib; Ubiquitination | 2017 |
Endothelial cell-related autophagic pathways in Sugen/hypoxia-exposed pulmonary arterial hypertensive rats.
Topics: Animals; Autophagy; Cell Proliferation; Endothelial Cells; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Indoles; Lung; Male; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor | 2017 |
Design, synthesis, and biological evaluation of pyrrolobenzodiazepine-containing hypoxia-activated prodrugs.
Topics: Benzodiazepines; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Humans; Hypoxia; Molecular Structure; NADPH-Ferrihemoprotein Reductase; Prodrugs; Pyrroles; Structure-Activity Relationship | 2017 |
Reactive oxygen species induced Ca
Topics: Angiogenesis Inhibitors; Animals; Calcium; Cells, Cultured; Endothelium, Vascular; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Microvessels; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; TRPV Cation Channels; Vascular Diseases | 2018 |
Nanocurcumin-pyrroloquinoline formulation prevents hypertrophy-induced pathological damage by relieving mitochondrial stress in cardiomyocytes under hypoxic conditions.
Topics: Animals; Cell Survival; Cells, Cultured; Curcumin; Hypertrophy; Hypertrophy, Right Ventricular; Hypoxia; Male; Mitochondria; Myocytes, Cardiac; Pyrroles; Quinolines; Rats; Rats, Sprague-Dawley | 2017 |
Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension.
Topics: Adaptation, Physiological; Animals; Apoptosis; Cell Proliferation; Endothelial Cells; Female; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Mice, Inbred C57BL; Pyrroles; Rats, Sprague-Dawley | 2018 |
DCE-MRI of Sunitinib-Induced Changes in Tumor Microvasculature and Hypoxia: A Study of Pancreatic Ductal Adenocarcinoma Xenografts.
Topics: Animals; Biomarkers; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Contrast Media; Disease Models, Animal; Female; Humans; Hypoxia; Image Enhancement; Immunohistochemistry; Indoles; Magnetic Resonance Imaging; Male; Mice; Neovascularization, Pathologic; Pancreatic Neoplasms; Pyrroles; Sunitinib; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2018 |
Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice.
Topics: Adoptive Transfer; Adult; Animals; Antibodies; Blood Pressure; Bone Marrow; Cell Proliferation; Chimera; Chronic Disease; Disease Models, Animal; Female; Gene Deletion; Humans; Hypertension, Pulmonary; Hypoxia; Immunity; Indoles; Lung; Lymphocyte Activation; Male; Mice; Ovalbumin; Pulmonary Artery; Pyrroles; Receptors, Immunologic; Receptors, Prostaglandin; STAT6 Transcription Factor; Th2 Cells; Up-Regulation | 2018 |
The Sugen 5416/Hypoxia Mouse Model of Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Pulmonary Artery; Pyrroles; Vascular Remodeling | 2018 |
Efficacy of treprostinil in the SU5416-hypoxia model of severe pulmonary arterial hypertension: haemodynamic benefits are not associated with improvements in arterial remodelling.
Topics: Angiogenesis Inhibitors; Animals; Antihypertensive Agents; Epoprostenol; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Protein Kinase Inhibitors; Pyrroles; Rats, Sprague-Dawley; Vascular Remodeling; Vasodilator Agents; Ventricular Function, Right | 2018 |
CrossTalk opposing view: The mouse SuHx model is not a good model of pulmonary arterial hypertension.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Mice; Pyrroles; Receptors, Vascular Endothelial Growth Factor | 2019 |
CrossTalk proposal: The mouse SuHx model is a good model of pulmonary arterial hypertension.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Mice; Pyrroles; Receptors, Vascular Endothelial Growth Factor | 2019 |
Macrophage-Derived Legumain Promotes Pulmonary Hypertension by Activating the MMP (Matrix Metalloproteinase)-2/TGF (Transforming Growth Factor)-β1 Signaling.
Topics: Animals; Caspase Inhibitors; Cysteine Endopeptidases; Extracellular Matrix Proteins; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Inflammation; Lung; Macrophages; Male; Matrix Metalloproteinase 2; Mice; Middle Aged; Monocrotaline; Pyrroles; Rats; Severity of Illness Index; Signal Transduction; Transforming Growth Factor beta1; Vascular Remodeling | 2019 |
Beneficial effects of mesenchymal stem cell delivery via a novel cardiac bioscaffold on right ventricles of pulmonary arterial hypertensive rats.
Topics: Animals; Arterial Pressure; Cells, Cultured; Disease Models, Animal; Fibrosis; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Mesenchymal Stem Cell Transplantation; Myocardial Contraction; Myocardium; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Recovery of Function; Regeneration; Tissue Scaffolds; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling; von Willebrand Factor | 2019 |
Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF-β (Transforming Growth Factor-β)-Dependent Pulmonary Arterial Hypertension.
Topics: Adolescent; Adult; Aged; Animals; Bone Morphogenetic Protein Receptors, Type II; Case-Control Studies; Caveolin 1; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Extracellular Vesicles; Female; Humans; Hypoxia; Indoles; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Nitric Oxide Synthase Type III; Pulmonary Arterial Hypertension; Pyrroles; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Vascular Remodeling; Young Adult | 2019 |
Inhibition of miR-495 Improves Both Vascular Remodeling and Angiogenesis in Pulmonary Hypertension.
Topics: Angiogenic Proteins; Animals; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Cells, Cultured; Dependovirus; Disease Models, Animal; Genetic Therapy; Genetic Vectors; Hypertension, Pulmonary; Hypoxia; Indoles; Lung; Male; Mice, Inbred C57BL; MicroRNAs; Microvessels; Neovascularization, Physiologic; Pyrroles; Recovery of Function; Signal Transduction; Vascular Remodeling | 2019 |
Severe Emphysema in the SU5416/Hypoxia Rat Model of Pulmonary Hypertension.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Protein Kinase Inhibitors; Pulmonary Emphysema; Pyrroles; Rats; X-Ray Microtomography | 2019 |
Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension.
Topics: Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Energy Metabolism; High-Throughput Screening Assays; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Male; Metabolome; Mice; Mitochondria; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthoquinones; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats; Reactive Oxygen Species; Resorcinols; Transcription Factors | 2019 |
SU5416 does not attenuate early RV angiogenesis in the murine chronic hypoxia PH model.
Topics: Angiogenesis Inhibitors; Animals; Chronic Disease; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Pyrroles | 2019 |
Atorvastatin protects against deleterious cardiovascular consequences induced by chronic intermittent hypoxia.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Blood Pressure; Cardiovascular Diseases; Disease Models, Animal; Heptanoic Acids; Hypoxia; Oxidative Stress; Pyrroles; Rats; Treatment Outcome | 2013 |
Expression of vascular endothelial growth factor (VEGF) and its receptors VEGFR1 and VEGFR2 in primary and recurrent WHO grade III meningiomas.
Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Brain Neoplasms; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Immunohistochemistry; In Situ Hybridization; Indoles; Male; Meningioma; Middle Aged; Pyrroles; Sunitinib; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2013 |
Activation of lung p53 by Nutlin-3a prevents and reverses experimental pulmonary hypertension.
Topics: Animals; Apoptosis; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Drug Evaluation, Preclinical; Endothelial Cells; Gene Expression Regulation; Genes, p53; Humans; Hypertension, Pulmonary; Hypoxia; Imidazoles; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Phosphorylation; Piperazines; Protein Processing, Post-Translational; Protein Stability; Pulmonary Artery; Pyrroles; Serotonin Plasma Membrane Transport Proteins; Single-Blind Method; Tumor Suppressor Protein p53; Ultrasonography | 2013 |
Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology.
Topics: Adult; Aged; Animals; Apoptosis; Arterial Pressure; Bone Morphogenetic Protein Receptors, Type II; Case-Control Studies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Glycation End Products, Advanced; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR gamma; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA Interference; S100 Proteins; Signal Transduction; STAT3 Transcription Factor; Transfection; Up-Regulation | 2013 |
Dehydroepiandrosterone restores right ventricular structure and function in rats with severe pulmonary arterial hypertension.
Topics: Animals; Apoptosis; Blood Pressure; Dehydroepiandrosterone; Fibrosis; Gene Expression; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Male; NADP; NFATC Transcription Factors; Oxidative Stress; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; STAT3 Transcription Factor; Ventricular Dysfunction | 2013 |
TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension.
Topics: Animals; Calcium Signaling; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypoxia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Pulmonary Artery; Pyrroles; Serotonin; Sulfonamides; Time Factors; TRPV Cation Channels; Vasoconstriction; Vasoconstrictor Agents | 2013 |
Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Endothelium, Vascular; Familial Primary Pulmonary Hypertension; Female; Hypertension, Pulmonary; Hypoxia; Indoles; Lac Operon; Male; Mice; Mice, Transgenic; Phenotype; Protein Serine-Threonine Kinases; Pulmonary Circulation; Pyrroles; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Receptors, Vascular Endothelial Growth Factor; Scleroderma, Systemic; Signal Transduction; Transforming Growth Factor beta | 2013 |
Spinal 5-HT7 receptors and protein kinase A constrain intermittent hypoxia-induced phrenic long-term facilitation.
Topics: Animals; Arterial Pressure; Blood Gas Analysis; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Data Interpretation, Statistical; Enzyme Inhibitors; Hypoglossal Nerve; Hypoxia; Injections, Spinal; Long-Term Potentiation; Male; NADPH Oxidases; Phenols; Phrenic Nerve; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, G-Protein-Coupled; Receptors, Serotonin; Serotonin Antagonists; Spinal Cord; Sulfonamides | 2013 |
Treatment with anti-gremlin 1 antibody ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension in mice.
Topics: Animals; Antibodies, Monoclonal; Bone Morphogenetic Proteins; Chronic Disease; Familial Primary Pulmonary Hypertension; Heart Ventricles; HEK293 Cells; Hemodynamics; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Intercellular Signaling Peptides and Proteins; Lung; Mice; Pyrroles; Signal Transduction | 2013 |
Changes in large pulmonary arterial viscoelasticity in chronic pulmonary hypertension.
Topics: Angiogenesis Inhibitors; Animals; Blood Pressure; Chronic Disease; Collagen; Elastic Modulus; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Proteoglycans; Pyrroles; Stress, Mechanical; Vascular Stiffness; Ventricular Dysfunction, Right; Viscosity | 2013 |
Temporal hemodynamic and histological progression in Sugen5416/hypoxia/normoxia-exposed pulmonary arterial hypertensive rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiogenesis Inhibitors; Animals; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2014 |
Atorvastatin attenuates involvement of RhoA/Rho-kinase pathway and NF-κB activation in hypoxic pulmonary hypertensive rats.
Topics: Animals; Atorvastatin; Blotting, Western; Heptanoic Acids; Hypertension, Pulmonary; Hypoxia; Male; NF-kappa B; Pyrroles; Random Allocation; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2014 |
Atorvastatin attenuates myocardial remodeling induced by chronic intermittent hypoxia in rats: partly involvement of TLR-4/MYD88 pathway.
Topics: Animals; Atorvastatin; Cardiomegaly; Cytokines; Heart; Heptanoic Acids; Hypoxia; Male; Myeloid Differentiation Factor 88; Myocardium; Oxidative Stress; Pyrroles; Rats; Rats, Wistar; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Sleep Apnea, Obstructive; Toll-Like Receptor 4; Ventricular Remodeling | 2014 |
Translocation of protein kinase C δ contributes to the moderately high glucose-, but not hypoxia-induced proliferation in primary cultured human retinal endothelial cells.
Topics: Acetophenones; Benzopyrans; Cell Proliferation; Cells, Cultured; Endothelial Cells; Gene Expression; Glucose; Humans; Hypoxia; Indoles; Primary Cell Culture; Protein Kinase C-delta; Protein Transport; Pyrroles; Retinal Pigment Epithelium | 2014 |
Nuclear factor κB inhibition reduces lung vascular lumen obliteration in severe pulmonary hypertension in rats.
Topics: Animals; Apoptosis; CD4-Positive T-Lymphocytes; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Inflammation; Interleukin-6; Leukocyte Common Antigens; Lung; NF-kappa B; Pulmonary Artery; Pyrroles; Pyrrolidines; Rats; Signal Transduction; Thiocarbamates; Time Factors | 2014 |
NPY/Y₁ receptor-mediated vasoconstrictory and proliferative effects in pulmonary hypertension.
Topics: Adult; Animals; Arginine; Cell Proliferation; Epinephrine; Female; Humans; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Indoles; Lung; Male; Mice, Inbred C57BL; Monocrotaline; Myocytes, Smooth Muscle; Neuropeptide Y; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Vasoconstriction; Vasoconstrictor Agents; Young Adult | 2014 |
SuHx rat model: partly reversible pulmonary hypertension and progressive intima obstruction.
Topics: Angiogenesis Inhibitors; Animals; Circadian Rhythm; Disease Models, Animal; Disease Progression; Echocardiography; Heart Ventricles; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Lung; Male; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Systole; Telemetry; Tunica Intima; Vascular Remodeling | 2014 |
Direct and indirect protection of right ventricular function by estrogen in an experimental model of pulmonary arterial hypertension.
Topics: Animals; Arterial Pressure; Cardiotonic Agents; Compliance; Disease Models, Animal; Drug Implants; Estradiol; Estrogen Replacement Therapy; Estrogens; Female; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Mice, Inbred C57BL; Myocardial Contraction; Ovariectomy; Pulmonary Artery; Pyrroles; Stroke Volume; Time Factors; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right | 2014 |
NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling.
Topics: Adventitia; Animals; Antihypertensive Agents; Cell Movement; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Matrix; Familial Primary Pulmonary Hypertension; Fibroblasts; HEK293 Cells; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Monocrotaline; NADPH Oxidase 4; NADPH Oxidases; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Time Factors; Transfection; Up-Regulation | 2014 |
Twist1 expression induced by sunitinib accelerates tumor cell vasculogenic mimicry by increasing the population of CD133+ cells in triple-negative breast cancer.
Topics: AC133 Antigen; Adult; Aged; Angiogenesis Inhibitors; Animals; Antigens, CD; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Hypoxia; Indoles; MCF-7 Cells; Mice; Mice, Nude; Middle Aged; Neoplasm Transplantation; Neoplastic Cells, Circulating; Nuclear Proteins; Peptides; Pyrroles; Sunitinib; Triple Negative Breast Neoplasms; Twist-Related Protein 1 | 2014 |
Iloprost reverses established fibrosis in experimental right ventricular failure.
Topics: Animals; Collagen; Cyclic AMP-Dependent Protein Kinases; Echocardiography; Fibroblasts; Fibrosis; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Iloprost; Indoles; Male; Matrix Metalloproteinase 9; Microscopy, Phase-Contrast; Physical Conditioning, Animal; Procollagen; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta1; Vasodilator Agents; Ventricular Function, Right | 2015 |
Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension.
Topics: Animals; Apelin; Arterioles; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelial Cells; Fibroblast Growth Factor 2; Hemodynamics; Histone Deacetylase Inhibitors; Hydroxamic Acids; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Intercellular Signaling Peptides and Proteins; Male; MEF2 Transcription Factors; MicroRNAs; Monocrotaline; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Transcription, Genetic | 2015 |
Lipid nanoparticle delivery of a microRNA-145 inhibitor improves experimental pulmonary hypertension.
Topics: Animals; Hypertension, Pulmonary; Hypoxia; Indoles; Lipids; Liposomes; Lung; Male; MicroRNAs; Nanoparticles; Oligonucleotides; Pyrroles; Rats, Sprague-Dawley | 2015 |
Sunitinib Treatment Exacerbates Intratumoral Heterogeneity in Metastatic Renal Cancer.
Topics: Aged; Antineoplastic Agents; Biomarkers; Carcinoma, Renal Cell; Clinical Trials, Phase II as Topic; Cluster Analysis; Comparative Genomic Hybridization; DNA-Binding Proteins; Drug Design; Female; Gene Expression Profiling; Genotype; Humans; Hypoxia; Indoles; Kidney Neoplasms; Male; Middle Aged; Mutation; Neoplasm Metastasis; Nephrectomy; Nuclear Proteins; Pilot Projects; Protein Array Analysis; Protein Kinase Inhibitors; Pyrroles; RNA, Messenger; Sunitinib; Transcription Factors; Von Hippel-Lindau Tumor Suppressor Protein | 2015 |
Peroxisome Proliferator-Activated Receptor γ and microRNA 98 in Hypoxia-Induced Endothelin-1 Signaling.
Topics: 3' Untranslated Regions; Animals; Binding Sites; Cell Proliferation; Cells, Cultured; Endothelial Cells; Endothelin-1; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; PPAR gamma; Pulmonary Artery; Pyrroles; RNA Interference; Rosiglitazone; Signal Transduction; Thiazolidinediones; Transfection; Vascular Remodeling | 2016 |
Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake.
Topics: Animals; Biological Transport; Fatty Acid Transport Proteins; Fatty Acids; Female; Glucose; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Lipoprotein Lipase; Oxidation-Reduction; Positron-Emission Tomography; Protein Kinase Inhibitors; Pyrroles; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor | 2015 |
Marked Strain-Specific Differences in the SU5416 Rat Model of Severe Pulmonary Arterial Hypertension.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Pyrroles; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Sprague-Dawley; Species Specificity | 2016 |
Detrimental Impact of Vasopressin V2 Receptor Antagonism in a SU5416/Hypoxia/Normoxia-Exposed Rat Model of Pulmonary Arterial Hypertension.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vasopressin; Up-Regulation; Ventricular Remodeling | 2016 |
Suppression of TRPV4 channels ameliorates anti-dipsogenic effects under hypoxia in the subfornical organ of rats.
Topics: Animals; Calcium; Cell Line; Drinking; Gadolinium; HEK293 Cells; Heme Oxygenase (Decyclizing); Humans; Hydrogen-Ion Concentration; Hypoxia; Male; Morpholines; Neurons; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sodium; Subfornical Organ; Temperature; TRPV Cation Channels; Urea | 2016 |
Erythropoietin improves hypoxic-ischemic encephalopathy in neonatal rats after short-term anoxia by enhancing angiogenesis.
Topics: Angiogenesis Inducing Agents; Animals; Animals, Newborn; Cognition; Disease Models, Animal; Erythropoietin; Hippocampus; Hypoxia; Hypoxia-Ischemia, Brain; Indoles; Male; Pyrroles; Random Allocation; Rats, Sprague-Dawley; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; White Matter | 2016 |
Osteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin αvβ3/FAK/AKT Pathway Suppression.
Topics: Animals; Arterial Pressure; Case-Control Studies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Focal Adhesion Kinase 1; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Integrin alphaVbeta3; Male; Mice, Knockout; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Osteoprotegerin; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; RNA Interference; Severity of Illness Index; Signal Transduction; Transfection; Vascular Remodeling; Walk Test | 2017 |
Chronic Embolic Pulmonary Hypertension Caused by Pulmonary Embolism and Vascular Endothelial Growth Factor Inhibition.
Topics: Animals; Cardiomegaly; Cell Proliferation; Chronic Disease; Heart Function Tests; Hemodynamics; Hyperplasia; Hypertension, Pulmonary; Hypoxia; Indoles; Ki-67 Antigen; Lung; Male; Microspheres; Oxygen Consumption; P-Selectin; Partial Pressure; Physical Conditioning, Animal; Plasminogen Activator Inhibitor 1; Polystyrenes; Pulmonary Embolism; Pyrroles; Rats, Sprague-Dawley; Tissue Inhibitor of Metalloproteinase-1; Vascular Endothelial Growth Factor A; Ventricular Dysfunction | 2017 |
Hypoxia-induced retinal angiogenesis in zebrafish as a model to study retinopathy.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Green Fluorescent Proteins; Humans; Hypoxia; Indoles; Microscopy, Confocal; Neovascularization, Pathologic; Pyrroles; Receptors, Notch; Retinal Diseases; Retinal Neovascularization; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor A; Zebrafish | 2008 |
Coagulation factor Xa activates thrombin in ischemic neural tissue.
Topics: Animals; Animals, Newborn; Anticoagulants; Cell Death; Factor Xa; Fondaparinux; Gene Expression Regulation; Glucose; Hippocampus; Hypoxia; Ischemia; JNK Mitogen-Activated Protein Kinases; Organ Culture Techniques; Polysaccharides; Pyrroles; Quinazolines; Rats; Receptor, PAR-1; Serine; Signal Transduction; Thrombin | 2009 |
Dynamic contrast-enhanced magnetic resonance imaging of vascular changes induced by sunitinib in papillary renal cell carcinoma xenograft tumors.
Topics: Animals; Antineoplastic Agents; Capillary Permeability; Carcinoma, Renal Cell; Contrast Media; Female; Gadolinium DTPA; Humans; Hypoxia; Immunoprecipitation; Indoles; Kidney Neoplasms; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Pyrroles; Receptors, Platelet-Derived Growth Factor; Sunitinib; Tumor Cells, Cultured; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays | 2009 |
CREB activation mediates VEGF-A's protection of neurons and cerebral vascular endothelial cells.
Topics: Animals; Animals, Newborn; Brain Injuries; Cell Survival; Cells, Cultured; Chromones; CREB-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Glial Fibrillary Acidic Protein; Glucose; Hypoxia; Hypoxia-Ischemia, Brain; Indoles; Injections, Intraventricular; Male; Morpholines; Neurons; Phosphorylation; Placenta Growth Factor; Platelet Endothelial Cell Adhesion Molecule-1; Pregnancy Proteins; Pyrroles; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction; Time Factors; Transfection; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2010 |
Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors.
Topics: Angiogenesis Inhibitors; Animals; Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Cell Movement; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoenzyme Techniques; Indoles; Mice; Mice, Inbred NOD; Mice, SCID; Neovascularization, Pathologic; Neuroblastoma; Proto-Oncogene Proteins c-kit; Proto-Oncogene Proteins c-ret; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Receptors, Interleukin-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Sunitinib; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-3; Xenograft Model Antitumor Assays | 2010 |
Microtubule-targeting-compound PBOX-15 radiosensitizes cancer cells in vitro.
Topics: Aerobiosis; Apoptosis; Cell Cycle; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Microtubules; Neoplasms; Oxazepines; Pyrroles; Radiation Tolerance; Radiation-Sensitizing Agents | 2011 |
[Atorvastatin attenuates hypoxic pulmonary hypertension in rats by inhibiting RhoA/Rho kinase pathway].
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Hemodynamics; Heptanoic Acids; Hypertension, Pulmonary; Hypoxia; Male; Pulmonary Artery; Pyrroles; Random Allocation; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Ventricular Remodeling | 2011 |
Peptide-directed highly selective targeting of pulmonary arterial hypertension.
Topics: Amino Acid Sequence; Animals; Drug Delivery Systems; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Lung; Male; Molecular Sequence Data; Monocrotaline; Peptides; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; Time Factors | 2011 |
C-type natriuretic peptide does not attenuate the development of pulmonary hypertension caused by hypoxia and VEGF receptor blockade.
Topics: Animals; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Lung; Male; Natriuretic Agents; Natriuretic Peptide, C-Type; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor | 2011 |
A novel murine model of severe pulmonary arterial hypertension.
Topics: Acute Disease; Animals; Blotting, Western; Cytokines; Disease Models, Animal; Echocardiography; Female; Fluorescent Antibody Technique; Gene Expression Profiling; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Indoles; Lung; Male; Mice; Mice, Inbred C57BL; Pyrroles; Receptors, Vascular Endothelial Growth Factor | 2011 |
Use of atorvastatin to inhibit hypoxia-induced myocardin expression.
Topics: Animals; Animals, Newborn; Atorvastatin; Blotting, Western; Cells, Cultured; Electrophoretic Mobility Shift Assay; Extracellular Signal-Regulated MAP Kinases; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy; Hypoxia; Myocytes, Cardiac; Nuclear Proteins; Pyrroles; Rats; Rats, Wistar; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Trans-Activators | 2012 |
Copper dependence of angioproliferation in pulmonary arterial hypertension in rats and humans.
Topics: Animals; Caspases; Cell Division; Cells, Cultured; Chelating Agents; Copper; Diet; Endothelium, Vascular; Enzyme Activation; Humans; Hypertension, Pulmonary; Hypoxia; Immunohistochemistry; Indoles; Male; Microvessels; Molybdenum; Neovascularization, Pathologic; Pyrroles; Rats; Rats, Sprague-Dawley | 2012 |
The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats.
Topics: Animals; Apoptosis; Blood Pressure; Blotting, Western; Caspase 3; Cell Proliferation; Cyclic GMP; Guanylate Cyclase; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Immunohistochemistry; Indoles; Lung; Male; Nitric Oxide Synthase Type III; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sildenafil Citrate; Soluble Guanylyl Cyclase; Sulfones; Time Factors; Treatment Outcome | 2012 |
Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats.
Topics: Animals; Caffeine; Calcium Channel Agonists; Calcium Signaling; Cell Hypoxia; Cells, Cultured; Dantrolene; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Macrocyclic Compounds; Male; Morpholines; Muscle Contraction; Muscle Relaxants, Central; Myocytes, Smooth Muscle; Oxazoles; Patch-Clamp Techniques; Phorbols; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Ryanodine; Ryanodine Receptor Calcium Release Channel; TRPV Cation Channels | 2012 |
Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression.
Topics: Animals; Benzamides; Disease Models, Animal; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Imatinib Mesylate; Indoles; Mice; Mice, Knockout; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Serotonin; Tryptophan Hydroxylase | 2013 |
Upregulation of PVN CRHR1 by gestational intermittent hypoxia selectively triggers a male-specific anxiogenic effect in rat offspring.
Topics: Animals; Anxiety; Behavior, Animal; Female; Hypoxia; Male; Paraventricular Hypothalamic Nucleus; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Sex Factors | 2013 |
Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure.
Topics: Angiography; Animals; Animals, Newborn; Birth Weight; Chronic Disease; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Lung; Pulmonary Alveoli; Pulmonary Artery; Pulmonary Circulation; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Stress, Physiological | 2002 |
Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the rat.
Topics: Animals; Hypoxia; Lipid Peroxidation; Male; Maze Learning; Oxidative Stress; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Sleep Apnea Syndromes; Spatial Behavior | 2003 |
THE ROLE OF SH AND S-S GROUPS AND OXYGEN IN THE ANAPHYLACTIC REACTION OF CHOPPED GUINEA-PIG LUNG.
Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Benzoates; Chloromercuribenzoates; Cysteine; Glutathione; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Hypoxia; Lung; Manometry; Oxygen; Pharmacology; Pyrroles; Research; Sulfhydryl Compounds; Sulfites; Thioglycolates | 1964 |
Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms.
Topics: Animals; Apoptosis; Cell Survival; Hypoxia; Indoles; Microcirculation; Models, Biological; Neoplasms; Neovascularization, Pathologic; Oxindoles; Pericytes; Platelet-Derived Growth Factor; Propionates; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2004 |
Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Blotting, Western; Butadienes; Cell Division; Cell Line, Tumor; Chromones; Deoxycytidine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gemcitabine; Humans; Hypoxia; Mitogen-Activated Protein Kinases; Morpholines; Neovascularization, Pathologic; NF-kappa B; Nitriles; Oxygen; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Signal Transduction; Sp1 Transcription Factor; Time Factors; Tyrosine | 2004 |
CRH receptor type 1 mediates continual hypoxia-induced changes of immunoreactive prolactin and prolactin mRNA expression in rat pituitary.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Animals; Cold Temperature; Corticotropin-Releasing Hormone; Hypoxia; Immunohistochemistry; Male; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Pituitary Gland; Prolactin; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Restraint, Physical; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stress, Psychological | 2006 |
A synthetic NCAM-derived peptide, FGL, protects hippocampal neurons from ischemic insult both in vitro and in vivo.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Count; Cells, Cultured; Drug Interactions; Glucose; Hippocampus; Hypoxia; Neural Cell Adhesion Molecules; Neurons; Neuroprotective Agents; Organ Culture Techniques; Phosphorylation; Propidium; Pyridinium Compounds; Pyrroles; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Fibroblast Growth Factor; Synapses; Tetrazolium Salts; Thiazoles; Time Factors | 2005 |
Atorvastatin prevents hypoxia-induced inhibition of endothelial nitric oxide synthase expression but does not affect heme oxygenase-1 in human microvascular endothelial cells.
Topics: Atherosclerosis; Atorvastatin; Blotting, Western; Cells, Cultured; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypoxia; Microcirculation; Nitric Oxide Synthase Type III; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction | 2006 |
Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Atorvastatin; CD55 Antigens; CD59 Antigens; Cells, Cultured; Cobalt; Cytoprotection; Deferoxamine; Diterpenes; Endothelial Cells; Endothelium, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia; Iron Chelating Agents; Mevalonic Acid; Pyrroles; RNA, Messenger; Up-Regulation | 2006 |
Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Disease Progression; Endothelin A Receptor Antagonists; Hypertension, Pulmonary; Hypoxia; Indoles; Intracellular Signaling Peptides and Proteins; Male; Myosin-Light-Chain Phosphatase; Organ Culture Techniques; Peptides, Cyclic; Phosphorylation; Protein Serine-Threonine Kinases; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vascular Endothelial Growth Factor Receptor-2; Vasoconstriction; Vasodilator Agents | 2007 |
Effects of hypoxia on glucose, insulin, glucagon, and modulation by corticotropin-releasing factor receptor type 1 in the rat.
Topics: Altitude; Animals; Blood Glucose; Body Weight; Corticosterone; Eating; Glucagon; Hypoxia; Insulin; Leptin; Liver Glycogen; Male; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone | 2007 |
Acute hypoxia induces vasodilation and increases coronary blood flow by activating inward rectifier K(+) channels.
Topics: Acute Disease; Adenine; Animals; Blood Pressure; Carbazoles; Coronary Circulation; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Glyburide; Hypoxia; In Vitro Techniques; Indoles; Male; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pyrroles; Rabbits; Signal Transduction; Thionucleotides; Vasodilation | 2007 |
Corticotropin-releasing hormone receptor 1 coexists with endothelin-1 and modulates its mRNA expression and release in rat paraventricular nucleus during hypoxia.
Topics: Animals; Corticosterone; Endothelin-1; Gene Expression Regulation; Hypoxia; Male; Paraventricular Hypothalamic Nucleus; Pyrimidines; Pyrroles; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; RNA, Messenger; Time Factors | 2008 |
[Experimental pulmonary hypertension (author's transl)].
Topics: Animals; Cattle; Dogs; Hypertension, Pulmonary; Hypoxia; Monocrotaline; Pyrroles; Pyrrolizidine Alkaloids; Rabbits; Rats; Sheep; Species Specificity; Swine | 1981 |
Mechanisms of hypoxic vasodilation in ferret pulmonary arteries.
Topics: Animals; Benzopyrans; Cromakalim; Cyclooxygenase Inhibitors; Ferrets; Hypoxia; Male; Nitric Oxide Synthase; Potassium Channel Blockers; Potassium Channels; Pulmonary Artery; Pyrroles; Vasodilation; Vasomotor System | 1995 |
Effect of L-NMMA, cromakalim, and glibenclamide on cerebral blood flow in hypercapnia and hypoxia.
Topics: Animals; Arginine; Arteries; Benzopyrans; Cerebrovascular Circulation; Cromakalim; Glyburide; Hypercapnia; Hypoxia; Nitric Oxide Synthase; omega-N-Methylarginine; Pyrroles; Rats; Theophylline; Vasodilator Agents | 1995 |
Effects of levcromakalim and glibenclamide on paced guinea-pig atrial strips exposed to hypoxia.
Topics: Animals; Benzopyrans; Cardiac Pacing, Artificial; Cromakalim; Deoxyglucose; Dose-Response Relationship, Drug; Female; Glyburide; Glycolysis; Guinea Pigs; Heart Atria; Hypoxia; In Vitro Techniques; Male; Myocardial Contraction; Parasympatholytics; Potassium Channels; Pyrroles | 1995 |
Cellular mechanisms of hypoxia-induced contraction in human and rat pulmonary arteries.
Topics: Aged; Animals; Benzopyrans; Calcium; Calcium Channels; Cromakalim; Glyburide; Humans; Hypoxia; In Vitro Techniques; Iodoacetates; Iodoacetic Acid; Male; Middle Aged; Muscle, Smooth, Vascular; Nifedipine; Potassium Channels; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Vasoconstriction; Verapamil | 1995 |
Glibenclamide inhibits hypoxic relaxation of isolated porcine coronary arteries under conditions of impaired glycolysis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Deoxyglucose; Endothelium, Vascular; Glyburide; Glycolysis; Hypoxia; In Vitro Techniques; Indomethacin; Isometric Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Swine; Theophylline; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1994 |
The sensitivity of coronary vascular tone to glibenclamide: a study on the isolated perfused guinea pig heart.
Topics: Animals; Benzopyrans; Biological Assay; Coronary Vessels; Cromakalim; Glyburide; Guinea Pigs; Hypoxia; In Vitro Techniques; Muscle, Smooth, Vascular; Perfusion; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
[Cardioprotective effect of levcromakalim in isolated guinea pig heart preparations].
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cardiotonic Agents; Cromakalim; Energy Metabolism; Glycogen; Guinea Pigs; Heart; Hypoxia; In Vitro Techniques; Lactates; Myocardium; Phosphocreatine; Pyrroles | 1994 |
Effect of levcromakalim on hypoxia-, KCl- and prostaglandin F2 alpha-induced contractions in isolated rat pulmonary artery.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Dinoprost; Endothelium, Vascular; Hypoxia; In Vitro Techniques; Male; Potassium Chloride; Pulmonary Artery; Pyrroles; Quaternary Ammonium Compounds; Rats; Vasoconstriction; Vasodilator Agents | 1994 |
Differential effects of hypoxia on electrical and mechanical activities of isolated ventricular muscles from fetal and adult guinea-pigs.
Topics: Action Potentials; Adenosine Triphosphate; Aging; Animals; Benzopyrans; Cromakalim; Depression, Chemical; Electrophysiology; Female; Guinea Pigs; Heart; Heart Ventricles; Hypoxia; In Vitro Techniques; Kinetics; Male; Myocardial Contraction; Potassium Channels; Pregnancy; Pyrroles; Ventricular Function | 1994 |
Modulation of vasodilatation to levcromakalim by adenosine analogues in the rabbit ear: an explanation for hypoxic augmentation.
Topics: Adenosine; Animals; Arginine; Benzopyrans; Blood Pressure; Cromakalim; Drug Synergism; Ear, External; Guanidines; Hypoxia; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Pinacidil; Pyrroles; Rabbits; Regional Blood Flow; Vasodilation; Vasodilator Agents; Xanthines | 1994 |
Role of potassium channels in hypoxic relaxation of porcine bronchi in vitro.
Topics: Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Carbachol; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hypoxia; In Vitro Techniques; Isoproterenol; Muscle Relaxation; Potassium Channels; Pyrroles; Swine | 1994 |
Attenuation by phentolamine of hypoxia and levcromakalim-induced abbreviation of the cardiac action potential.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Drug Interactions; Glucose; Glyburide; Guinea Pigs; Heart; Hypoxia; In Vitro Techniques; Kinetics; Papillary Muscles; Phentolamine; Potassium Channels; Pyrroles | 1993 |
Pyrrolostatin, a novel lipid peroxidation inhibitor from Streptomyces chrestomyceticus. Taxonomy, fermentation, isolation, structure elucidation and biological properties.
Topics: Animals; Brain; Fermentation; Hypoxia; Lipid Peroxidation; Male; Mice; Proline; Pyrroles; Rats; Rats, Wistar; Streptomyces | 1993 |
Modulation of vasodilatation to levcromakalim by hypoxia and EDRF in the rabbit isolated ear: a comparison with pinacidil, sodium nitroprusside and verapamil.
Topics: Acetylcholine; Animals; Arginine; Benzopyrans; Cromakalim; Ear, External; Guanidines; Hypoxia; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxidative Phosphorylation; Pinacidil; Piperazines; Pyrroles; Rabbits; Receptors, N-Methyl-D-Aspartate; Regional Blood Flow; Vasodilator Agents; Verapamil | 1993 |
Glibenclamide does not reverse attenuated vasoreactivity to acute or chronic hypoxia.
Topics: Acute Disease; Adenosine Triphosphate; Animals; Benzopyrans; Blood Gas Analysis; Blood Pressure; Chronic Disease; Cromakalim; Glyburide; Heart Rate; Hemodynamics; Hypoglycemic Agents; Hypoxia; Male; Phenylephrine; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vascular Resistance; Vasoconstrictor Agents | 1995 |
Protective effect of KBT-3022, a new cyclooxygenase inhibitor, in cerebral hypoxia and ischemia.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hippocampus; Hypoxia; Male; Mice; Pyrroles; Thiazoles | 1995 |
Acute hypoxic vasoconstriction in isolated rat small and large pulmonary arteries.
Topics: Acute Disease; Amlodipine; Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Endothelium, Vascular; Hypoxia; In Vitro Techniques; Male; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Vasoconstriction; Vasodilator Agents | 1995 |
In vitro hypoxia on rat pulmonary artery: effects on contractions to spasmogens and role of KATP channels.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Cromakalim; Drug Interactions; Glyburide; Hypoxia; In Vitro Techniques; Male; Potassium Channel Blockers; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Thromboxane A2; Vasoconstrictor Agents | 1996 |
alpha 1-Adrenoceptor stimulation partially inhibits ATP-sensitive K+ current in guinea pig ventricular cells: attenuation of the action potential shortening induced by hypoxia and K+ channel openers.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Female; Guinea Pigs; Heart; Heart Ventricles; Hypoxia; Male; Methoxamine; Niacinamide; Nicorandil; Papillary Muscles; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Ventricular Function | 1996 |
ATP-sensitive potassium channels in isolated rat aorta during physiologic, hypoxic, and low-glucose conditions.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Endothelium, Vascular; Glyburide; Hypoglycemia; Hypoxia; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 1997 |
Hypoxia-induced hyperpolarization is not associated with vasodilation of bovine coronary resistance arteries.
Topics: Acetylcholine; Animals; Benzopyrans; Bradykinin; Calcium; Cattle; Coronary Vessels; Cromakalim; Endothelium, Vascular; Glyburide; Hypoxia; In Vitro Techniques; Membrane Potentials; Microelectrodes; Microscopy, Video; Oxygen; Perfusion; Pyrroles; Vascular Resistance; Vasodilation; Vasodilator Agents | 1997 |
Role of activation of calcium-sensitive K+ channels in NO- and hypoxia-induced pial artery vasodilation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Arterioles; Benzimidazoles; Benzopyrans; Cerebral Arteries; Cromakalim; Cyclic GMP; Female; Hypoxia; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Penicillamine; Pia Mater; Potassium Channels; Pyrroles; S-Nitroso-N-Acetylpenicillamine; Swine; Vasodilation; Vasodilator Agents | 1997 |
Pulmonary vasoreactivity to serotonin during hypoxia is modulated by ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Arteries; Benzopyrans; Blood Pressure; Capillaries; Cromakalim; Dogs; Female; Hypoxia; Male; Potassium Channels; Pulmonary Circulation; Pyrroles; Serotonin; Serotonin Antagonists; Vascular Resistance; Vasoconstrictor Agents; Vasodilator Agents; Veins | 1997 |
TRH mimetics: differentiation of antiamnesic potency from antidepressant effect.
Topics: Amino Acid Sequence; Amnesia; Animals; Antidepressive Agents; Azocines; Electroencephalography; Hypoxia; Magnetic Resonance Spectroscopy; Mice; Molecular Sequence Data; Protein Conformation; Pyrazines; Pyrroles; Rats; Thyrotropin-Releasing Hormone | 1997 |
Cardiorespiratory responses to systemic administration of a protein kinase C inhibitor in conscious rats.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Heart Rate; Hypercapnia; Hypoxia; Indoles; Male; Neocortex; Protein Kinase C; Pulmonary Ventilation; Pyrroles; Rats; Rats, Sprague-Dawley | 1998 |
Tirilazad widens the therapeutic window for riluzole-induced attenuation of progressive cortical degeneration in an infant rat model of the shaken baby syndrome.
Topics: Age Factors; Animals; Battered Child Syndrome; Body Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Free Radical Scavengers; Glutamic Acid; Head Injuries, Closed; Humans; Hypoxia; Infant; Lipid Peroxidation; Male; Nerve Degeneration; Neuroprotective Agents; Pregnatrienes; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Riluzole; Time Factors | 1998 |
Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Blood Pressure; Caspase 3; Caspases; Cell Death; Cell Division; Endothelium, Vascular; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Muscle, Smooth, Vascular; Myocardium; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor | 2001 |
Opposing actions of tolbutamide and glibenclamide on hypoxic pulmonary vasoconstriction.
Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Glyburide; Hypoxia; In Vitro Techniques; Lung; Male; Potassium Channels; Pyrroles; Rats; Tolbutamide; Vasoconstriction | 1992 |
[Effect of potassium channel openers on hypoxic pulmonary vasoconstriction].
Topics: Angiotensin II; Animals; Benzopyrans; Cromakalim; Guanidines; Hypoxia; In Vitro Techniques; Pinacidil; Potassium Channels; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilator Agents | 1992 |
Evidence that epithelium-dependent relaxation of vascular smooth muscle detected by co-axial bioassays is not attributable to hypoxia.
Topics: Animals; Aorta; Benzopyrans; Biological Assay; Biological Factors; Cromakalim; Epithelium; Glyburide; Guinea Pigs; Hypoxia; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Pyrroles; Rats; Rats, Inbred Strains; Respiratory Physiological Phenomena | 1992 |
Hypoxia-evoked dilatation of rabbit isolated basilar arteries is not mediated by the opening of glibenclamide-sensitive potassium channels.
Topics: Animals; Basilar Artery; Benzopyrans; Cromakalim; Glyburide; Hypoxia; In Vitro Techniques; Male; Potassium Channels; Pyrroles; Rabbits; Vasodilation; Vasodilator Agents | 1992 |
Anoxia and glucose-sensitive 86Rb outflow from rat portal vein.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Glucose; Guanidines; Hypoxia; Permeability; Pinacidil; Portal Vein; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes | 1992 |
Aziridinyl nitropyrroles and nitropyrazoles as hypoxia-selective cytotoxins and radiosensitizers.
Topics: Animals; Aziridines; Cell Line; Cell Survival; Cricetinae; Cricetulus; Cytotoxins; Free Radicals; Hypoxia; In Vitro Techniques; Magnetic Resonance Spectroscopy; Nitro Compounds; Polarography; Pyrazoles; Pyrroles; Radiation-Sensitizing Agents | 1991 |
ATP-dependent K+ channels modulate vasoconstrictor responses to severe hypoxia in isolated ferret lungs.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Ferrets; Glucose; Glyburide; Hypoxia; In Vitro Techniques; Lung; Male; Oxygen; Potassium Channels; Pyrroles; Vasoconstriction; Vasodilator Agents | 1991 |
Pulmonary and systemic haemodynamic effects of cromakalim in conditions of normoxia and hypoxia in dogs.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Hemodynamics; Hypoxia; Infusions, Intravenous; Lung; Pulmonary Circulation; Pyrroles; Time Factors; Vasodilator Agents | 1990 |
Hypoxic dilation of coronary arteries is mediated by ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Bradykinin; Coronary Vessels; Cromakalim; Endothelium, Vascular; Glyburide; Guinea Pigs; Hypoxia; In Vitro Techniques; Ischemia; Potassium Channels; Pyrroles; Vasodilation | 1990 |
Contrasting effects of hypoxia on tension in rat pulmonary and mesenteric arteries.
Topics: Animals; Benzopyrans; Cromakalim; Endothelium, Vascular; Glyburide; Hypoxia; In Vitro Techniques; Male; Mesenteric Arteries; Potassium; Pulmonary Artery; Pyrroles; Rats; Rats, Inbred Strains; Rest; Vasoconstriction; Vasodilator Agents; Verapamil | 1990 |
BRL 34915 (cromakalim) activates ATP-sensitive K+ current in cardiac muscle.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Electrophysiology; Ferrets; Glyburide; Guinea Pigs; Heart; Hypoxia; Ion Channels; Myocardium; Potassium; Pyrroles | 1988 |