pyrroles and Glioma
pyrroles has been researched along with Glioma in 49 studies
Research
Studies (49)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (6.12) | 18.2507 |
| 2000's | 10 (20.41) | 29.6817 |
| 2010's | 35 (71.43) | 24.3611 |
| 2020's | 1 (2.04) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Andreasson, KI; Ceribelli, M; Chen, L; Duveau, DY; Ferrer, M; Geraghty, AC; Ghanem, R; Gillespie, SM; Guha, R; Itkin, Z; Klumpp-Thomas, C; Kreimer, S; Lennon, J; Lin, GL; McKnight, C; Michael, S; Michalowski, AM; Minhas, P; Monje, M; Morris, PJ; Nagaraja, S; Ni, L; Qin, EY; Quezada, M; Raabe, EH; Shinn, P; Stanton, BZ; Thomas, CJ; Vitanza, NA; Warren, KE; Wilson, KM; Woo, PJ; Zhang, X | 1 |
| Boccellato, C; Fullstone, G; Idbaih, A; Juric, V; Kolbe, E; Lamfers, MLM; Murphy, BM; Peters, N; Rehm, M; Verreault, M | 1 |
| Akkari, L; Huse, JT; Joyce, JA; Kowal, J; Schuhmacher, AJ; West, BL; Yan, D | 1 |
| Li, B; Liang, H; Ou-Yang, Q; Xu, M | 1 |
| Bai, Y; Liu, M; Shen, D; Tao, S; Wang, T; Zhang, W | 1 |
| Chen, S; Cheng, H; Dai, X; Liu, L; Shen, H; Zhang, P | 1 |
| Auf, G; Bayerl, SH; Broggini, T; Bruenner, J; Czabanka, M; Harms, C; Harms, U; Heppner, FL; Jabouille, A; Koch, A; Kremenetskaia, I; Mueller, S; Nieminen, M; Parmaksiz, G; Topalovic, M; Vajkoczy, P | 1 |
| Chang, KW; Huang, BM; Huang, YL; Ju, TK; Su, PH; Wong, ZR; Yang, HY | 1 |
| Kabadere, S; Kus, G; Oztopcu-Vatan, P; Uyar, R | 1 |
| Czabanka, M; Parmaksız, G; Vajkoczy, P; Vinci, M | 1 |
| Andrews, DW; Axelrod, R; Camphausen, K; Curran, WJ; Dicker, AP; Evans, J; Glass, J; Haacke, EM; Hillman, GG; Lin, A; Shi, W; Werner-Wasik, M; Wuthrick, EJ | 1 |
| Bogdahn, U; Bosserhoff, AK; Brawanski, A; Hau, P; Heudorfer, F; Leukel, P; Meyer, K; Moeckel, S; Proescholdt, M; Riemenschneider, MJ; Seliger, C; Spang, R; Stangl, C; Vollmann-Zwerenz, A | 1 |
| Barnhart, TE; Cai, W; Chen, F; Goel, S; Hernandez, R; Hong, H; Shi, S; Valdovinos, HF | 1 |
| Buchfelder, M; Eyüpoglu, IY; Fan, Z; Ghoochani, A; Hatipoglu, G; Hock, SW; Savaskan, NE; Sehm, T; Weiss, R | 1 |
| Finke, JH; Grabowski, M; Hambardzumyan, D; Huang, P; Raychaudhuri, B; Rayman, P; Vogelbaum, MA | 1 |
| Chen, M; Hui, H; Jin, B; Ma, P; Pei, S; Shen, F; Wang, Z; Zhou, W; Zhou, X | 1 |
| Blaes, J; Broggini, T; Czabanka, M; Harms, C; Harms, U; Mueller, S; Stange, L; Thomé, C; Vajkoczy, P; Weiler, M; Wick, W; Wüstner, M | 1 |
| Du Four, S; Duerinck, J; Everaert, H; Hau, P; Michotte, A; Neyns, B; Sander, W; Van Binst, AM | 1 |
| Abraham, V; Bota, DA; Burrows, FJ; Desjardins, A; Di, K; Lloyd, GK; MacLaren, A; Trikha, M | 1 |
| Bogdahn, U; Bosserhoff, AK; Brawanski, A; Hau, P; Moeckel, S; Proescholdt, M; Riemenschneider, MJ; Spang, R; Vollmann-Zwerenz, A | 1 |
| Billups, CA; Blaney, SM; Boyett, JM; Daryani, VM; Gajjar, A; Goldsmith, KC; Leary, S; Stewart, CF; Tanos, R; Wetmore, C | 1 |
| Anderson, KC; Burrows, FJ; Chauhan, D; Harrison, SJ; Levin, N; Reich, SD; Richardson, PG; Spencer, A; Trikha, M | 1 |
| Fang, L; Jiang, K; Wang, D; Wang, J; Zhao, J; Zhu, L | 1 |
| Gallo, JM; Zhou, Q | 2 |
| Bengzon, J; Bexell, D; Darabi, A; Gisselsson, D; Gunnarsson, S; Roybon, L; Scheding, S; Tormin, A | 1 |
| Montgomery, JP; Patterson, PH | 1 |
| Argyriou, AA; Dimitrakopoulos, F; Dimitropoulos, K; Giannopoulou, E; Kalofonos, HP; Koutras, AK | 1 |
| Garcia-Echeverria, C; Hägerstrand, D; Hofmann, F; Lindh, MB; Nistér, M; Ostman, A; Peña, C | 1 |
| Chaskis, C; De Greve, J; Duerinck, J; Dujardin, M; Everaert, H; Lv, S; Michotte, A; Neyns, B; Nupponen, N; Sadones, J; Tynninen, O | 1 |
| Claes, A; Hamans, BC; Heerschap, A; Jeuken, JW; Leenders, WP; Navis, AC; Wesseling, P | 1 |
| Fousteris, M; Koutsourea, A; Lampropoulou, E; Manioudaki, M; Nikolaropoulos, S; Papadimitriou, E | 1 |
| Coan, A; Desjardins, A; Friedman, HS; Gururangan, S; Herndon, JE; Peters, KB; Reardon, DA; Rich, JN; Sathornsumetee, S; Vredenburgh, JJ | 1 |
| Barré, L; Bernaudin, M; Delamare, J; Divoux, D; Marteau, L; Petit, E; Roussel, S; Sobrio, F; Toutain, J; Valable, S | 1 |
| Chopp, M; Ding, C; Jiang, F; Jiang, J; Lu, Y; Yang, H; Zhang, L; Zhao, D; Zheng, X | 1 |
| DE Grève, J; DE Witte, O; DU Four, S; Huylebrouck, M; LE Mercier, M; Lv, S; Michotte, A; Neyns, B; Quartier, E; Sadones, J; Salmon, I; Teugels, E | 1 |
| Chamberlain, M; Chowdhary, S; Pan, E; Potthast, L; Smith, P; Yu, D; Yue, B | 1 |
| Gallo, JM; Lv, H; Ma'ayan, A; Mazloom, AR; Xu, H; Zhou, Q | 1 |
| Burrell, K; Camphausen, K; Chung, C; Foltz, W; Graves, C; Jaffray, D; Jalali, S; Lindsay, P; Ménard, C; Milosevic, M; Wildgoose, P; Zadeh, G | 1 |
| Garber, MM; Heiman, AS | 1 |
| Gallo, JM; Guo, P; Li, S; Ma, J; Reed, K | 1 |
| Capelle, HH; Erber, R; Farhadi, MR; Ullrich, A; Vajkoczy, P | 1 |
| Gallo, JM; Guo, P; Zhou, Q | 1 |
| Matsumura, K; Mochizuki-Oda, N; Oosawa, Y; Takeuchi, Y; Watanabe, Y | 1 |
| App, H; Fong, TA; Hirth, KP; Kim, YH; McMahon, G; Powell, TJ; Risau, W; Schreck, R; Shawver, LK; Sun, L; Tang, C; Ullrich, A; Wang, X | 1 |
| Fong, TA; Ge, S; Goldbrunner, R; Hirth, KP; Menger, MD; Rempel, SA; Schilling, L; Schmiedek, P; Tonn, JC; Ullrich, A; Vajkoczy, P; Vollmar, B | 1 |
| Blaivas, M; Kish, PE; McMahon, G; Muraszko, KM; Ross, BD; Ross, DA; Strawderman, M | 1 |
| Kuno, T; Sasaki, M; Takamoto, T; Tamaki, N | 1 |
| Higashida, H; Ito, Y; Matsubara, T; Miyamori, I; Takeda, R | 1 |
Trials
6 trial(s) available for pyrroles and Glioma
| Article | Year |
|---|---|
Sunitinib Malate plus Lomustine for Patients with Temozolomide-refractory Recurrent Anaplastic or Low-grade Glioma.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Glioma; Humans; Indoles; Lomustine; Male; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Pyrroles; Sunitinib; Survival Rate; Temozolomide | 2015 |
Phase II evaluation of sunitinib in the treatment of recurrent or refractory high-grade glioma or ependymoma in children: a children's Oncology Group Study ACNS1021.
Topics: Adolescent; Angiogenesis Inhibitors; Antineoplastic Agents; Child; Child, Preschool; Combined Modality Therapy; Drug Monitoring; Drug Resistance, Neoplasm; Ependymoma; Female; Glioma; Humans; Indoles; Male; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasm Staging; Protein Kinase Inhibitors; Pyrroles; Retreatment; Sunitinib; Treatment Outcome; Young Adult | 2016 |
Marizomib irreversibly inhibits proteasome to overcome compensatory hyperactivation in multiple myeloma and solid tumour patients.
Topics: Caspases; Chymotrypsin; Enzyme Activation; Glioma; Humans; Lactones; Multiple Myeloma; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrroles; Trypsin | 2016 |
Phase II study of sunitinib malate in patients with recurrent high-grade glioma.
Topics: Adult; Aged; Antineoplastic Agents; Central Nervous System Neoplasms; Cerebrovascular Circulation; Disease Progression; Female; Glioma; Humans; Indoles; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Proto-Oncogene Proteins c-kit; Pyrroles; Pyrrolidinones; Receptors, Platelet-Derived Growth Factor; Recurrence; Regional Blood Flow; Sunitinib; Vascular Endothelial Growth Factor Receptor-2 | 2011 |
Phase I study of sunitinib and irinotecan for patients with recurrent malignant glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Disease-Free Survival; Female; Glioma; Humans; Indoles; Irinotecan; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Pyrroles; Sunitinib; Young Adult | 2011 |
A prospective phase II single-institution trial of sunitinib for recurrent malignant glioma.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Disease-Free Survival; Female; Glioma; Humans; Indoles; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Pyrroles; Sunitinib | 2012 |
Other Studies
43 other study(ies) available for pyrroles and Glioma
| Article | Year |
|---|---|
Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening.
Topics: Animals; Brain Neoplasms; Brain Stem Neoplasms; Cell Death; Cell Line, Tumor; Drug Evaluation, Preclinical; Drug Synergism; Female; Glioma; High-Throughput Screening Assays; Humans; Lactones; Male; Metabolomics; Mice; Panobinostat; Pyrroles; Reproducibility of Results; Sequence Analysis, RNA; Transcription, Genetic; Xenograft Model Antitumor Assays | 2019 |
Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 8; Cell Line, Tumor; Drug Resistance, Neoplasm; Glioma; Humans; Lactones; Myeloid Cell Leukemia Sequence 1 Protein; Proteasome Inhibitors; Pyrimidines; Pyrroles; Receptors, TNF-Related Apoptosis-Inducing Ligand; Signal Transduction; Spheroids, Cellular; Thiophenes; Time Factors | 2021 |
Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas.
Topics: Aminopyridines; Animals; Becaplermin; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Glioma; Humans; Mice; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Tumor Microenvironment | 2017 |
TRPV4 promotes the migration and invasion of glioma cells via AKT/Rac1 signaling.
Topics: Blotting, Western; Cell Line, Tumor; Cell Movement; Glioma; Humans; Leucine; Morpholines; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; Pyrroles; rac1 GTP-Binding Protein; Signal Transduction; Sulfonamides; TRPV Cation Channels | 2018 |
TGF-β/Smads Signaling Affects Radiation Response and Prolongs Survival by Regulating DNA Repair Genes in Malignant Glioma.
Topics: Acid Anhydride Hydrolases; Animals; ATP-Binding Cassette Transporters; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; DNA Damage; DNA Glycosylases; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Gamma Rays; Gene Expression Regulation, Neoplastic; Glioma; Humans; Mice; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neuroglia; Pyrazoles; Pyrroles; RNA, Small Interfering; Signal Transduction; Smad Proteins; Survival Analysis; Transforming Growth Factor beta; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2018 |
Anti-glioma trichobamide A with an unprecedented tetrahydro-5H-furo[2,3-b]pyrrol-5-one functionality from ascidian-derived fungus Trichobotrys effuse 4729.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Down-Regulation; Fungi; Glioma; Humans; Magnetic Resonance Spectroscopy; Molecular Conformation; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Tumor Suppressor Protein p53; Up-Regulation; Urochordata | 2019 |
Combined temozolomide and sunitinib treatment leads to better tumour control but increased vascular resistance in O6-methylguanine methyltransferase-methylated gliomas.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Proliferation; Dacarbazine; DNA Methylation; DNA, Neoplasm; Glioma; Heterografts; Humans; Indoles; Male; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Pyrroles; Sunitinib; Temozolomide; Tumor Cells, Cultured; Vascular Resistance | 2013 |
Fibroblast growth factor-2 up-regulates the expression of nestin through the Ras-Raf-ERK-Sp1 signaling axis in C6 glioma cells.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 2; Gene Expression Regulation, Neoplastic; Glioma; Intermediate Filament Proteins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nerve Tissue Proteins; Nestin; Pyrroles; raf Kinases; ras Proteins; Rats; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Fibroblast Growth Factor, Type 3; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sp1 Transcription Factor; Up-Regulation | 2013 |
Cytotoxic and apoptotic functions of licofelone on rat glioma cells.
Topics: Animals; Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Drug Screening Assays, Antitumor; Flow Cytometry; Glioma; Pyrroles; Rats | 2013 |
Antiangiogenic therapy inhibits the recruitment of vascular accessory cells to the perivascular niche in glioma angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Biomarkers, Tumor; Bone Marrow Cells; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Glioma; Indoles; Mice; Mice, Nude; Neovascularization, Pathologic; Pyrroles; Rats; Sunitinib; Tumor Microenvironment | 2014 |
A pilot study of hypofractionated stereotactic radiation therapy and sunitinib in previously irradiated patients with recurrent high-grade glioma.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Disease-Free Survival; Dose Fractionation, Radiation; Drug Administration Schedule; Female; Glioma; Humans; Indoles; Male; Middle Aged; Neoplasm Recurrence, Local; Pilot Projects; Pyrroles; Radiosurgery; Remission Induction; Retreatment; Sunitinib | 2014 |
Response-predictive gene expression profiling of glioma progenitor cells in vitro.
Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Pharmacological; Brain Neoplasms; Cell Differentiation; Cell Proliferation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Humans; Indoles; Microarray Analysis; Neoplasm Proteins; Neoplastic Stem Cells; Pyrroles; Signal Transduction; Sunitinib; Tumor Cells, Cultured | 2014 |
VEGF₁₂₁-conjugated mesoporous silica nanoparticle: a tumor targeted drug delivery system.
Topics: Animals; Drug Delivery Systems; Glioblastoma; Glioma; Humans; Indoles; Mice; Nanoparticles; Pyrroles; Silicon Dioxide; Sunitinib; Vascular Endothelial Growth Factor Receptor-1; Xenograft Model Antitumor Assays | 2014 |
Sunitinib impedes brain tumor progression and reduces tumor-induced neurodegeneration in the microenvironment.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Astrocytes; Brain Neoplasms; Cell Death; Cell Line, Tumor; Cell Proliferation; Disease Progression; Endothelial Cells; Glioma; Humans; Indoles; Mice; Neovascularization, Pathologic; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Pyrroles; Rats; Rodentia; Sunitinib; Tumor Microenvironment; Vascular Endothelial Growth Factor Receptor-2 | 2015 |
Myeloid derived suppressor cell infiltration of murine and human gliomas is associated with reduction of tumor infiltrating lymphocytes.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Brain; Brain Neoplasms; Cell Line; Chickens; Glioma; Humans; Indoles; Lymphocytes, Tumor-Infiltrating; Mice, Transgenic; Myeloid Cells; Neoplasm Transplantation; Protein-Tyrosine Kinases; Pyrroles; Spleen; Sunitinib; Survival Analysis; T-Lymphocytes; Treatment Outcome | 2015 |
GSK1838705A, an IGF-1R inhibitor, inhibits glioma cell proliferation and suppresses tumor growth in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Glioma; Humans; Mice; Mice, Nude; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Signal Transduction; Xenograft Model Antitumor Assays | 2015 |
NDRG1 overexpressing gliomas are characterized by reduced tumor vascularization and resistance to antiangiogenic treatment.
Topics: Angiogenesis Inhibitors; Animals; Brain Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Culture Media, Conditioned; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioma; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Mice; Mutation; Neovascularization, Pathologic; Neovascularization, Physiologic; NF-kappa B; Promoter Regions, Genetic; Pyrroles; RNA Interference; Signal Transduction; Sunitinib; Time Factors; Transcription Factor AP-1; Transfection; Tumor Burden; Tumor Necrosis Factor Ligand Superfamily Member 15; Up-Regulation | 2016 |
Marizomib activity as a single agent in malignant gliomas: ability to cross the blood-brain barrier.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Cell Line, Tumor; Disease Models, Animal; Glioma; Lactones; Mice, Inbred BALB C; Mice, Nude; Proteasome Inhibitors; Pyrroles | 2016 |
Validation Study: Response-Predictive Gene Expression Profiling of Glioma Progenitor Cells In Vitro.
Topics: Brain Neoplasms; Cell Proliferation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Humans; Indoles; Microarray Analysis; Neoplastic Stem Cells; Pyrroles; Sunitinib | 2016 |
Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma.
Topics: Animals; Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Glioma; Humans; Immunohistochemistry; Jumonji Domain-Containing Histone Demethylases; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Nuclear Proteins; Phosphorylation; Pyrazoles; Pyrroles; Repressor Proteins; RNA, Messenger; Smad2 Protein; Spheroids, Cellular | 2016 |
Differential effect of sunitinib on the distribution of temozolomide in an orthotopic glioma model.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Drug Interactions; Glioma; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Indoles; Male; Mice; Mice, Nude; Pyrroles; Sunitinib; Temozolomide; Tissue Distribution; Xenograft Model Antitumor Assays | 2009 |
Bone marrow multipotent mesenchymal stroma cells act as pericyte-like migratory vehicles in experimental gliomas.
Topics: Animals; Antigens; Bone Marrow Cells; Cell Line, Tumor; Cell Movement; Dermoscopy; Female; Flow Cytometry; Genetic Therapy; Glioma; Immunohistochemistry; In Situ Hybridization, Fluorescence; Indoles; Male; Mesenchymal Stem Cells; Proteoglycans; Pyrroles; Rats; Receptors, Platelet-Derived Growth Factor; Stromal Cells; Sunitinib | 2009 |
Endothelin receptor B antagonists decrease glioma cell viability independently of their cognate receptor.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Ciprofloxacin; DNA Damage; Endothelin B Receptor Antagonists; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Humans; Isoquinolines; Melanoma; Oligonucleotide Array Sequence Analysis; Pyrroles; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; RNA, Small Interfering | 2008 |
An in vitro study, evaluating the effect of sunitinib and/or lapatinib on two glioma cell lines.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Glioma; Humans; Indoles; Lapatinib; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Pyrroles; Quinazolines; Sunitinib | 2010 |
Quantification of sunitinib in mouse plasma, brain tumor and normal brain using liquid chromatography-electrospray ionization-tandem mass spectrometry and pharmacokinetic application.
Topics: Angiogenesis Inhibitors; Animals; Brain; Brain Neoplasms; Chromatography, Liquid; Drug Stability; Glioma; Humans; Indoles; Infusions, Intravenous; Male; Mice; Mice, Nude; Pyrroles; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Sunitinib; Tandem Mass Spectrometry; Tissue Distribution | 2010 |
PI3K/PTEN/Akt pathway status affects the sensitivity of high-grade glioma cell cultures to the insulin-like growth factor-1 receptor inhibitor NVP-AEW541.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Glioma; Humans; Immunoblotting; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction | 2010 |
Effects of targeting the VEGF and PDGF pathways in diffuse orthotopic glioma models.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Blood-Brain Barrier; Brain Neoplasms; Glioma; Humans; Indoles; Magnetic Resonance Imaging; Mice; Mice, Nude; Neovascularization, Pathologic; Piperidines; Pyrroles; Quinazolines; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2011 |
Pyrrolo[2,3-α]carbazole derivatives as topoisomerase I inhibitors that affect viability of glioma and endothelial cells in vitro and angiogenesis in vivo.
Topics: Angiogenesis Inhibitors; Animals; Carbazoles; Cell Line, Tumor; Cell Proliferation; Chick Embryo; Chorioallantoic Membrane; DNA Topoisomerases, Type I; Endothelial Cells; Glioma; Humans; Neovascularization, Pathologic; Neovascularization, Physiologic; Pyrroles; Rats; Topoisomerase I Inhibitors | 2011 |
Complementary information from magnetic resonance imaging and (18)F-fluoromisonidazole positron emission tomography in the assessment of the response to an antiangiogenic treatment in a rat brain tumor model.
Topics: Angiogenesis Inhibitors; Animals; Biological Transport; Brain; Brain Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cerebrovascular Circulation; Disease Models, Animal; Glioma; Indoles; Kinetics; Magnetic Resonance Imaging; Misonidazole; Neovascularization, Pathologic; Permeability; Positron-Emission Tomography; Pyrroles; Rats; Sunitinib; Treatment Outcome | 2011 |
Atorvastatin reduces functional deficits caused by photodynamic therapy in rats.
Topics: Animals; Astrocytes; Atorvastatin; Brain; Cell Line, Tumor; Cell Proliferation; Dihematoporphyrin Ether; Endothelial Cells; Glioma; Heptanoic Acids; Humans; Mental Disorders; Neovascularization, Physiologic; Neuroprotective Agents; Photochemotherapy; Pyrroles; Rats; Rats, Inbred F344; Synaptophysin; Vascular Endothelial Growth Factor A; von Willebrand Factor | 2011 |
Correlation between IDH1 gene mutation status and survival of patients treated for recurrent glioma.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Brain Neoplasms; Cetuximab; ErbB Receptors; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Humans; Indoles; Isocitrate Dehydrogenase; Male; Middle Aged; Mutation; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Recurrence; Sunitinib | 2011 |
Activation of alternate prosurvival pathways accounts for acquired sunitinib resistance in U87MG glioma xenografts.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Blotting, Western; Drug Resistance, Neoplasm; Fluorescent Antibody Technique; Glioma; Graft Survival; Humans; Indoles; Male; Mice; Mice, Nude; Microdialysis; Neoplasm Transplantation; Neovascularization, Pathologic; Phenotype; Phospholipase C gamma; Polymerase Chain Reaction; Pyrroles; Sunitinib | 2012 |
Imaging biomarker dynamics in an intracranial murine glioma study of radiation and antiangiogenic therapy.
Topics: Angiogenesis Inhibitors; Animals; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Diffusion Magnetic Resonance Imaging; Glioma; Indoles; Mice; Mice, Inbred NOD; Mice, SCID; Pyrroles; Radiotherapy, Conformal; Sunitinib; Tumor Burden | 2013 |
The in vitro effects of Pb acetate on NO production by C6 glial cells.
Topics: Animals; Carbazoles; Cytokines; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Glioma; Indoles; Neuroglia; Nitric Oxide; Organometallic Compounds; Protein Kinase Inhibitors; Pyrroles; Rats; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 2002 |
Pharmacodynamic-mediated effects of the angiogenesis inhibitor SU5416 on the tumor disposition of temozolomide in subcutaneous and intracerebral glioma xenograft models.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Dacarbazine; Disease Models, Animal; Drug Interactions; Glioma; Indoles; Neoplasm Transplantation; Neoplasms, Experimental; Pyrroles; Rats; Rats, Nude; Receptors, Vascular Endothelial Growth Factor; Temozolomide; Tumor Cells, Cultured | 2003 |
Combined inhibition of vascular endothelial growth factor and platelet-derived growth factor signaling: effects on the angiogenesis, microcirculation, and growth of orthotopic malignant gliomas.
Topics: Animals; Apoptosis; Brain; Brain Neoplasms; Cell Division; Cell Line, Tumor; Cell Transformation, Neoplastic; Glioma; Indoles; Mice; Mice, Nude; Microcirculation; Microscopy, Fluorescence; Microscopy, Video; Neoplasm Transplantation; Neovascularization, Pathologic; Oxindoles; Platelet-Derived Growth Factor; Propionates; Protein-Tyrosine Kinases; Pyrroles; Rats; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Transplantation, Heterologous; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2005 |
Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Blotting, Western; Collagen; Collagen Type IV; Dacarbazine; Drug Combinations; Glioma; Immunoenzyme Techniques; Indoles; Laminin; Male; Mice; Mice, Nude; Neovascularization, Pathologic; Platelet Endothelial Cell Adhesion Molecule-1; Proteoglycans; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sunitinib; Temozolomide; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2008 |
Hypoxia-induced catecholamine release and intracellular Ca2+ increase via suppression of K+ channels in cultured rat adrenal chromaffin cells.
Topics: Animals; Benzopyrans; Buffers; Calcium; Carotid Body; Catecholamines; Cell Hypoxia; CHO Cells; Chromaffin Cells; Cricetinae; Cromakalim; Diazoxide; Glioma; Glyburide; Guanidines; Hybrid Cells; Hypoglycemic Agents; Male; Membrane Potentials; Minoxidil; Neuroblastoma; Parasympatholytics; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1997 |
SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.
Topics: 3T3 Cells; Animals; Catalysis; Cell Division; Endothelium, Vascular; Enzyme Inhibitors; Glioma; Humans; Indoles; Mice; Neoplasms, Experimental; Neovascularization, Pathologic; Protein-Tyrosine Kinases; Pyrroles; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Mitogen; Receptors, Vascular Endothelial Growth Factor; Tumor Cells, Cultured | 1999 |
Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC.
Topics: Angiogenesis Inhibitors; Animals; Biomarkers, Tumor; Cell Division; Cell Movement; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glioma; Immunohistochemistry; Indoles; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Microscopy, Video; Neoplasm Invasiveness; Neoplasm Transplantation; Neovascularization, Pathologic; Osteonectin; Pyrroles; Rats; Solvents; Time Factors; Tumor Cells, Cultured | 2000 |
Magnetic resonance imaging of ethyl-nitrosourea-induced rat gliomas: a model for experimental therapeutics of low-grade gliomas.
Topics: Angiogenesis Inhibitors; Animals; Brain Neoplasms; Carcinogens; Diet; Disease Models, Animal; Diterpenes; Ethylnitrosourea; Glioma; Indoles; Magnetic Resonance Imaging; Neoplasms, Multiple Primary; Neoplasms, Second Primary; Pyrroles; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Retinyl Esters; Survival Analysis; Time Factors; Vitamin A | 2001 |
Flk-1 specific kinase inhibitor (SU5416) inhibited the growth of GS-9L glioma in rat brain and prolonged the survival.
Topics: Animals; Apoptosis; Brain; Brain Neoplasms; Enzyme Inhibitors; Glioma; Indoles; Male; Microcirculation; Pyrroles; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Survival Rate | 2001 |
Cromakalim, a vasodilator, differentially inhibits Ca2+ currents in NG108-15 neuroblastoma x glioma hybrid cells.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Biological Transport; Calcium; Cromakalim; Glioma; Hybrid Cells; Membrane Potentials; Mice; Neuroblastoma; Parasympatholytics; Pyrroles; Tumor Cells, Cultured; Vasodilator Agents | 1990 |