pyrroles has been researched along with Aging in 63 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (9.52) | 18.7374 |
| 1990's | 11 (17.46) | 18.2507 |
| 2000's | 20 (31.75) | 29.6817 |
| 2010's | 23 (36.51) | 24.3611 |
| 2020's | 3 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, X; Han, Z; Lei, P; Li, M; Li, X; Liu, M; Liu, Q; Zhang, W | 1 |
| Feng, W; Islam, SMT; Khan, M; Kumar, P; Qiao, F; Singh, AK; Singh, I; Won, JS | 1 |
| Choi, HD; Choi, JY; Jeong, YJ; Lee, HJ; Nam, KR; Oh, SJ; Shin, NR; Son, Y | 1 |
| Ball, DJ; Bowman, CJ; Collinge, M; Nilson, AL; Radi, ZA; Vogel, WM | 1 |
| Aki, R; Ito, T; Matsushita, Y; Miyake, H; Motoyama, D; Otsuka, A; Sugiyama, T; Tamura, K | 1 |
| Bennett, RE; Bryant, A; Hopp, SC; Hu, M; Hyman, BT; Robbins, AB | 1 |
| Ito, S; Itou, T; Wakamatsu, K | 1 |
| Becker, ML; de Keyser, CE; Hofman, A; Klungel, OH; Maitland-van der Zee, AH; Peters, BJ; Stricker, BH; Uitterlinden, AG; Verstuyft, C; Visser, LE | 1 |
| Baglietto-Vargas, D; Bitner, RS; Castello, NA; Cheng, D; Decker, MW; Esbenshade, TA; Green, KN; Kitazawa, M; LaFerla, FM; Medeiros, R | 1 |
| Han, L; Li, MG; Ye, P | 1 |
| Fu, G; Gong, X; Ma, Y; Ruan, Y; Wu, S | 1 |
| Bjarnason, GA; Choueiri, TK; Donskov, F; Heng, DY; Khambati, HK; Knox, JJ; Kollmannsberger, CK; MacKenzie, MJ; North, S; Rini, BI; Tan, MH; Vaishampayan, UN; Wood, L | 1 |
| de Ceuninck, M; Trenson, S | 1 |
| D'Asti, E; Dombrovsky, A; Garnier, D; Lau, K; Magnus, N; Meehan, B; Rak, J | 1 |
| Jeong, YK; Jung, WG; Kim, EH; Lee, H | 1 |
| Pangallo, KC; Reddy, CM | 1 |
| Cui, W; Du, J; Han, M; Liu, DM; Liu, F; Lu, JC; Yin, HN; Zhang, HL; Zhang, K | 1 |
| Davy, KP; Dengo, AL; Orr, JS; Rivero, JM | 1 |
| Astarita, G; Barrett, E; Beckett, TL; Dowling, AL; Head, E; Kryscio, RJ; Levine, H; Lin, Y; Morales, J; Murphy, MP; Piomelli, D; Studzinski, CM; Wang, X; Weidner, A | 1 |
| Borden, EC; Byzova, TV; Kerr, BA; Malinin, NL; Merkulova, AA; Podrez, EA; Salomon, RG; Tischenko, M; West, XZ | 1 |
| Abe, K; Ikeda, Y; Kozuki, M; Kurata, T; Matsuura, T; Miyazaki, K; Morimoto, N; Nagai, M; Ohta, Y; Panin, VL | 1 |
| Clarke, R; Lynch, MA; Lyons, A; Murphy, KJ | 1 |
| Cheng, QL; Ye, P; Zhao, JH | 1 |
| Barone, E; Butterfield, DA; Cenini, G; Dowling, AL; Head, E; Mancuso, C; Martin, SB; Murphy, MP | 1 |
| Byzova, TV; Malinin, NL; West, XZ | 1 |
| Han, C; Han, L; Li, M; Liu, Y; Ye, P | 1 |
| Wang, H; Ye, P; Zhang, JY | 1 |
| Guo, Y; Wang, J; Xu, D; Xu, J; Yang, Z; Zhang, Y; Zhou, C | 1 |
| Fürst, DO; Granzow, M; Huss, S; Klein, S; Klösel, J; Körner, C; Lammert, F; Mazar, IG; Nattermann, J; Pieper-Fürst, U; Sauerbruch, T; Schierwagen, R; Trebicka, J; van den Ven, PF; Weber, S | 1 |
| Ikuta, H; Nagakura, T; Tanaka, I; Yamazaki, K; Yasuda, N | 1 |
| Birthelmer, A; Cassel, JC; Jackisch, R; Stemmelin, J | 1 |
| Birthelmer, A; Cassel, JC; Jackisch, R; Lazaris, A; Schweizer, T | 1 |
| Edlund, T; Gunhaga, L; Hsieh, JC; Jessell, TM; Marklund, M; Sjödal, M | 1 |
| LINNELL, RH; UMAR, S | 1 |
| Blauw, GJ; Meinders, AE; Weverling-Rijnsburger, AW | 1 |
| Baumeister, B; Berthold, HK; Degenhardt, R; Gouni-Berthold, I; Krone, W; Unverdorben, M; Unverdorben, S; Vetter, H; Zittermann, A | 1 |
| Alegret, M; Laguna, JC; Roglans, N; Sánchez, RM; Sanguino, E; Vázquez-Carrera, M | 1 |
| Amano, S; Horiuchi, S; Kaji, Y; Koito, W; Okamoto, F; Oshika, T | 1 |
| An, Y; Beehler, BC; Bi, Y; Fura, A; Golla, R; Grover, GJ; Hamann, LG; Kish, KF; Krystek, SR; Kuhns, JE; Lupisella, JA; Manfredi, MC; Mookhtiar, KA; Ostrowski, J; Sack, JS; Seethala, R; Sleph, PG; Sun, C | 1 |
| Nachtigal, P; Ouda, L; Semecký, V; Solichová, D; Syka, J | 1 |
| Arthur, CR; Cabot, MC; Gewirtz, DA; Gupton, JT; Kellogg, GE; Newsham, IF; Yeudall, WA | 1 |
| Arca, M | 1 |
| Anand-Apte, B; Crabb, JW; Ebrahem, Q; Gu, X; Lu, L; Renganathan, K; Salomon, RG; Sears, J; Vasanji, A | 1 |
| Bonilha, VL; Hollyfield, JG; Lu, L; Perez, VL; Rayborn, ME; Salomon, RG; Shadrach, KG; Ufret, RL; Yang, X | 1 |
| Hansen, HH; Hay-Schmidt, A; Martens, H; Mikkelsen, JD; Peters, D; Thomsen, MS; Timmermann, DB | 1 |
| Fukushima, N; Hayashi, C; Katayama, T; Misu, Y; Miyamae, T; Ueda, H | 1 |
| Agata, N; Kato, Y; Shigenobu, K; Tanaka, H | 1 |
| Carlson, EC; Marion, MS | 1 |
| Abe, I; Fujii, K; Fujishima, M; Kobayashi, K; Ohmori, S; Ohya, Y; Takata, Y; Tominaga, M | 1 |
| Monnier, VM; Nagaraj, RH; Portero-Otin, M | 1 |
| Fujii, K; Fujikawa, M; Fujishima, M; Ibayashi, S; Kitazono, T; Nagao, T; Takata, Y; Toyoda, K | 1 |
| Bailey, AJ; Paul, RG | 1 |
| Ahmed, MU; Baynes, JW; Brinkmann, E; Litchfield, JE; Reddy, S; Thorpe, SR; Wells-Knecht, KJ; Wells-Knecht, MC; Zyzak, DV | 1 |
| Bandla, HP; Gozal, D; Graff, GR; Simakajornboon, N | 1 |
| Derweesh, IH; Weiss, RM; Wheeler, MA | 1 |
| Cases, O; Gaspar, P; Goaillard, JM; Laurent, A; Lebrand, C; Ropert, N | 1 |
| Granger, AS; Kowaloff, EM; Phang, JM | 1 |
| Ljungberg, B; Nilsson-Ehle, I | 1 |
| Barthelmebs, M; Coquard, C; Giesen-Crouse, EM; Grima, M; Imbs, JL; Welsch, C | 1 |
| Hunter, JR; Jick, H; Jick, SS; Walker, AM | 1 |
| Hayase, F; Miyata, S; Monnier, VM; Nagaraj, RH; Njoroge, FG | 1 |
| Kador, PF; Kinoshita, JH; Shiono, T | 1 |
| Glenn, BL; Levin, EY; Romeo, G | 1 |
6 review(s) available for pyrroles and Aging
| Article | Year |
|---|---|
The SLCO1B1 c.521T>C polymorphism is associated with dose decrease or switching during statin therapy in the Rotterdam Study.
Topics: Aged; Aging; Anticholesteremic Agents; Atorvastatin; Cholesterol; Cytosine; Databases, Factual; Dose-Response Relationship, Drug; Female; Genetic Association Studies; Heptanoic Acids; Humans; Hypercholesterolemia; Liver-Specific Organic Anion Transporter 1; Male; Middle Aged; Organic Anion Transporters; Polymorphism, Single Nucleotide; Prospective Studies; Pyrroles; Risk Factors; Sex Characteristics; Simvastatin; Thymine | 2014 |
Oxidation as "the stress of life".
Topics: Aging; Animals; Humans; Neovascularization, Physiologic; Oxidation-Reduction; Oxidative Stress; Phospholipids; Pyrroles; Toll-Like Receptors | 2011 |
Atorvastatin: a safety and tolerability profile.
Topics: Aged; Aging; Alanine Transaminase; Aspartate Aminotransferases; Atorvastatin; Dose-Response Relationship, Drug; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Pyrroles | 2007 |
Carboxyethylpyrrole adducts, age-related macular degeneration and neovascularization.
Topics: Aged, 80 and over; Aging; Allantois; Animals; Chick Embryo; Child; Humans; Macular Degeneration; Mice; Middle Aged; Models, Biological; Molecular Structure; Neovascularization, Pathologic; Pyrroles | 2008 |
Glycation of collagen: the basis of its central role in the late complications of ageing and diabetes.
Topics: Aging; Animals; Arginine; Collagen; Cross-Linking Reagents; Diabetes Complications; Diabetes Mellitus; Elastin; Glycation End Products, Advanced; Glycosylation; Humans; Imidazoles; Lysine; Maillard Reaction; Malondialdehyde; Norleucine; Pyrroles | 1996 |
New biomarkers of Maillard reaction damage to proteins.
Topics: Aging; Arginine; Biomarkers; Diabetes Complications; Diabetes Mellitus; Glycation End Products, Advanced; Glycosylation; Humans; Lysine; Maillard Reaction; Molecular Structure; Norleucine; Oxidation-Reduction; Proteins; Pyrroles | 1996 |
2 trial(s) available for pyrroles and Aging
| Article | Year |
|---|---|
Arterial destiffening with atorvastatin in overweight and obese middle-aged and older adults.
Topics: Adult; Aged; Aging; Atorvastatin; Blood Flow Velocity; C-Reactive Protein; Cardiovascular Diseases; Carotid Arteries; Cholesterol, LDL; Double-Blind Method; Elasticity; Female; Femoral Artery; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Obesity; Overweight; Pyrroles; Regional Blood Flow; Risk Factors | 2009 |
Age-dependent effects of atorvastatin on biochemical bone turnover markers: a randomized controlled trial in postmenopausal women.
Topics: Aged; Aging; Atorvastatin; Biomarkers; Bone and Bones; Bone Density; Cardiovascular Diseases; Collagen; Collagen Type I; Double-Blind Method; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Middle Aged; Multivariate Analysis; Osteocalcin; Peptides; Postmenopause; Prospective Studies; Pyrroles; Risk Factors | 2004 |
55 other study(ies) available for pyrroles and Aging
| Article | Year |
|---|---|
Microglial replacement in the aged brain restricts neuroinflammation following intracerebral hemorrhage.
Topics: Aging; Aminopyridines; Animals; Blood-Brain Barrier; Brain; Brain Injuries; Cell Death; Cerebral Hemorrhage; Chemotaxis, Leukocyte; Disease Models, Animal; Mice; Microglia; Neuroinflammatory Diseases; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor | 2022 |
Targeting GSNOR for functional recovery in a middle-aged mouse model of stroke.
Topics: Aging; Alcohol Dehydrogenase; Animals; Benzamides; Disease Models, Animal; Drug Delivery Systems; Male; Mice; Mice, Inbred C57BL; Pyrroles; Recovery of Function; Stroke | 2020 |
Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice.
Topics: Aging; Alzheimer Disease; Aminopyridines; Amyloid; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Hippocampus; Humans; Macrophage Colony-Stimulating Factor; Mice; Mice, Transgenic; Pyrroles; Receptors, Colony-Stimulating Factor; Signal Transduction | 2020 |
Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses.
Topics: Administration, Oral; Aging; Animals; Antigens; Erythrocyte Count; Female; Hematocrit; Hemocyanins; Hemoglobins; Janus Kinase Inhibitors; Leukocyte Count; Leukocytes; Lymphoma, B-Cell; Macaca fascicularis; Male; Organ Size; Piperidines; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Spleen; Thymus Gland; Toxicity Tests, Chronic | 2018 |
Significance of Age in Japanese Patients Receiving Sunitinib as First-line Systemic Therapy for Metastatic Renal Cell Carcinoma: Comparative Assessment of Efficacy and Safety between Patients Aged <75 and ≥75 Years.
Topics: Aged; Aged, 80 and over; Aging; Antineoplastic Agents; Asian People; Carcinoma, Renal Cell; Disease-Free Survival; Fatigue; Female; Humans; Indoles; Japan; Kidney Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Pyrroles; Retrospective Studies; Sunitinib; Thrombocytopenia; Treatment Outcome | 2018 |
Partial reduction of microglia does not affect tau pathology in aged mice.
Topics: Aging; Aminopyridines; Animals; Blood Vessels; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cytokines; Disease Models, Animal; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; Mutation; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; RNA, Messenger; tau Proteins; Tauopathies | 2018 |
Effects of Aging on Hair Color, Melanosome Morphology, and Melanin Composition in Japanese Females.
Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Female; Hair; Hair Color; Humans; Indoles; Melanins; Melanosomes; Middle Aged; Organelle Size; Pyrroles | 2019 |
α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles.
Topics: Aging; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognition; Humans; Inflammation; Male; Memory; Mice; Mice, Transgenic; Neurofibrillary Tangles; Nootropic Agents; Phosphorylation; Plaque, Amyloid; Pyridazines; Pyrroles; tau Proteins | 2014 |
[The effect of PPARalpha signal channel on atorvastatin inhibiting MMP-9 expression in aging myocytes].
Topics: Aging; Animals; Atorvastatin; Cells, Cultured; Heptanoic Acids; Matrix Metalloproteinase 9; Muscle Cells; Oxazoles; PPAR alpha; Pyrroles; Rats; Rats, Wistar; Signal Transduction; Tyrosine | 2013 |
Long-term atorvastatin improves age-related endothelial dysfunction by ameliorating oxidative stress and normalizing eNOS/iNOS imbalance in rat aorta.
Topics: Aging; Animals; Aorta, Thoracic; Atorvastatin; Body Weight; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Male; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Pyrroles; Rats, Wistar; Sirtuin 1 | 2014 |
Efficacy of targeted therapy for metastatic renal cell carcinoma in the elderly patient population.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Carcinoma, Renal Cell; Databases, Factual; Female; Humans; Indoles; Kidney Neoplasms; Male; Molecular Targeted Therapy; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Retrospective Studies; Sorafenib; Sunitinib; Treatment Outcome; Vascular Endothelial Growth Factor A | 2014 |
A calcified left ventricular mass.
Topics: Aged, 80 and over; Aging; Amlodipine; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atorvastatin; Calcinosis; Diagnosis, Differential; Female; Heart Neoplasms; Heart Valve Diseases; Heptanoic Acids; Humans; Hypertension; Mitral Valve; Monitoring, Physiologic; Platelet Aggregation Inhibitors; Pyrroles; Quinapril; Radiography; Tetrahydroisoquinolines; Treatment Outcome | 2014 |
Ageing-related responses to antiangiogenic effects of sunitinib in atherosclerosis-prone mice.
Topics: Aging; Angiogenesis Inhibitors; Animals; Apolipoproteins E; Atherosclerosis; Carcinoma, Lewis Lung; Female; Indoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Neoplasm Transplantation; Pyrroles; Sunitinib; Treatment Outcome | 2014 |
Mechanisms of SU5416, an inhibitor of vascular endothelial growth factor receptor, as a radiosensitizer for colon cancer cells.
Topics: Adenocarcinoma; Aging; Antineoplastic Agents; Apoptosis; beta-Galactosidase; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; DNA Repair; HCT116 Cells; HT29 Cells; Humans; Indoles; Neoplasm Invasiveness; Pyrroles; Radiation Tolerance; Radiation-Sensitizing Agents; Reactive Oxygen Species; Receptors, Vascular Endothelial Growth Factor | 2016 |
Distribution patterns suggest biomagnification of halogenated 1'-methyl-1,2'-bipyrroles (MBPs).
Topics: Aging; Animals; Environmental Monitoring; Female; Hydrocarbons, Halogenated; Lipids; Liver; Male; Mammals; Pyrroles; Seawater; Tissue Distribution; Water Pollutants, Chemical | 2009 |
Additive beneficial effects of amlodipine and atorvastatin in reversing advanced cardiac hypertrophy in elderly spontaneously hypertensive rats.
Topics: Aging; Amlodipine; Animals; Anticholesteremic Agents; Antihypertensive Agents; Atorvastatin; Cardiomegaly; Drug Synergism; Drug Therapy, Combination; Fibrosis; Heart Failure, Diastolic; Hemodynamics; Heptanoic Acids; Myocytes, Cardiac; NADPH Oxidases; Natriuretic Peptide, Brain; Oxidative Stress; Pyrroles; Random Allocation; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Superoxide Dismutase; Ventricular Dysfunction, Left | 2009 |
Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs.
Topics: Aging; Amyloid beta-Peptides; Animals; Anticholesteremic Agents; Atorvastatin; Cholesterol; Cognition; Discrimination Learning; Dogs; Female; Heptanoic Acids; Male; Protein Processing, Post-Translational; Psychomotor Performance; Pyrroles; Random Allocation; Time Factors | 2010 |
Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands.
Topics: Aging; Animals; Aorta; Cell Line; Cell Movement; Endothelial Cells; Hindlimb; Humans; Immunity, Innate; Inflammation; Ischemia; Ligands; Melanoma; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Neovascularization, Pathologic; Neovascularization, Physiologic; Oxidation-Reduction; Oxidative Stress; Platelet Endothelial Cell Adhesion Molecule-1; Propionates; Pyrroles; rac1 GTP-Binding Protein; Receptors, Scavenger; Signal Transduction; Toll-Like Receptor 2; Toll-Like Receptor 4; Vascular Endothelial Growth Factor A; Wound Healing | 2010 |
Atorvastatin and pitavastatin improve cognitive function and reduce senile plaque and phosphorylated tau in aged APP mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Atorvastatin; Body Weight; Brain; Cognition Disorders; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Maze Learning; Mice; Mice, Transgenic; Neuroprotective Agents; Organ Size; Phosphorylation; Plaque, Amyloid; Protein Processing, Post-Translational; Pyrroles; Quinolines; tau Proteins | 2011 |
Atorvastatin prevents age-related and amyloid-β-induced microglial activation by blocking interferon-γ release from natural killer cells in the brain.
Topics: Aging; Amyloid beta-Peptides; Animals; Anticholesteremic Agents; Atorvastatin; Biomarkers; Brain; Heptanoic Acids; Interferon-gamma; Killer Cells, Natural; Male; Microglia; Natural Cytotoxicity Triggering Receptor 1; NK Cell Lectin-Like Receptor Subfamily B; Pyrroles; Rats; Rats, Wistar | 2011 |
[The effects of atorvastatin on aging kidney].
Topics: Aging; Animals; Anticholesteremic Agents; Arteriosclerosis; Atorvastatin; Female; Heptanoic Acids; Kidney; Kidney Diseases; Pyrroles; Rats; Rats, Wistar; Renal Artery | 2011 |
Coenzyme Q10 and cognition in atorvastatin treated dogs.
Topics: Aging; Animals; Atorvastatin; Cognition Disorders; Dogs; Female; Heptanoic Acids; Male; Mitochondria; Oxidative Phosphorylation; Oxidative Stress; Parietal Lobe; Pyrroles; Ubiquinone | 2011 |
Atorvastatin may delay cardiac aging by upregulating peroxisome proliferator-activated receptors in rats.
Topics: Aging; Animals; Anticholesteremic Agents; Atorvastatin; Blood Pressure; Cells, Cultured; Gene Expression Regulation; Heart; Heptanoic Acids; Inflammation Mediators; Myocardium; Oxidoreductases; Peroxisome Proliferator-Activated Receptors; Pyrroles; Rats; Rats, Wistar; Up-Regulation | 2012 |
[Protective effect of atrovastatin against myocardial ischemia-reperfusion injury and on liver and kidney functions in aged rats].
Topics: Aging; Animals; Atorvastatin; Female; Heptanoic Acids; Kidney; Liver; Male; Multiple Organ Failure; Myocardial Ischemia; Myocardial Reperfusion Injury; Pyrroles; Rats; Rats, Wistar | 2012 |
Improvement of arterial stiffness by reducing oxidative stress damage in elderly hypertensive patients after 6 months of atorvastatin therapy.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Anticholesteremic Agents; Arteries; Atorvastatin; Biomarkers; Endothelium, Vascular; Female; Heptanoic Acids; Humans; Hypertension; Male; Middle Aged; Oxidative Stress; Prospective Studies; Pyrroles; Statistics as Topic; Statistics, Nonparametric | 2012 |
Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats.
Topics: Actins; Aging; Animals; Apoptosis; Atorvastatin; beta-Galactosidase; Cell Proliferation; Collagen; Connective Tissue Growth Factor; Desmin; Dose-Response Relationship, Drug; Flow Cytometry; Hepatic Stellate Cells; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver Cirrhosis; Male; Myofibroblasts; Pyrroles; Rats; Rats, Sprague-Dawley; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta1 | 2012 |
Enteroinsular axis of db/db mice and efficacy of dipeptidyl peptidase IV inhibition.
Topics: Actins; Aging; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Male; Mice; Mice, Inbred C57BL; Peptide Fragments; Proglucagon; Protease Inhibitors; Protein Precursors; Pyrroles; Valine | 2003 |
Presynaptic modulation of acetylcholine, noradrenaline, and serotonin release in the hippocampus of aged rats with various levels of memory impairments.
Topics: Acetylcholine; Acetylcholinesterase; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Analysis of Variance; Animals; Behavior, Animal; Brimonidine Tartrate; Choline O-Acetyltransferase; Female; Hippocampus; Idazoxan; In Vitro Techniques; Maze Learning; Memory Disorders; Methiothepin; Muscarinic Agonists; Norepinephrine; Oxotremorine; Presynaptic Terminals; Pyridines; Pyrroles; Quinoxalines; Rats; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming; Tritium | 2003 |
Presynaptic regulation of neurotransmitter release in the cortex of aged rats with differential memory impairments.
Topics: Acetylcholine; Acetylcholinesterase; Adrenergic alpha-Agonists; Aging; Animals; Brimonidine Tartrate; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Chromatography, High Pressure Liquid; Electric Stimulation; Female; Maze Learning; Memory Disorders; Muscarinic Agonists; Neurotransmitter Agents; Norepinephrine; Oxotremorine; Pyridines; Pyrroles; Quinoxalines; Rats; Rats, Long-Evans; Receptors, Presynaptic; Serotonin; Serotonin Receptor Agonists | 2003 |
Specification of dorsal telencephalic character by sequential Wnt and FGF signaling.
Topics: Aging; Animals; Basic Helix-Loop-Helix Transcription Factors; Bone Morphogenetic Proteins; Cell Differentiation; Chick Embryo; Ectoderm; Embryonic Induction; Epithelium; Eye Proteins; Fibroblast Growth Factors; Frizzled Receptors; Gene Expression Regulation, Developmental; Homeodomain Proteins; Immunohistochemistry; In Situ Hybridization; Mice; Nerve Tissue Proteins; Organ Culture Techniques; Paired Box Transcription Factors; PAX6 Transcription Factor; Proteins; Proto-Oncogene Proteins; Pyrroles; Receptors, Fibroblast Growth Factor; Repressor Proteins; Signal Transduction; Stem Cells; Telencephalon; Transcription Factors; Wnt Proteins; Zebrafish Proteins | 2003 |
Aging effects in pyrrole.
Topics: Aging; Pyrroles | 1955 |
Effect of atorvastatin on impaired vascular function in healthy old men.
Topics: Acetylcholine; Adult; Aged; Aged, 80 and over; Aging; Anticholesteremic Agents; Atorvastatin; Brachial Artery; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Endothelium, Vascular; Forearm; Heptanoic Acids; Humans; Male; Nitroprusside; Plethysmography; Pyrroles; Reference Values; Regional Blood Flow; Serotonin; Triglycerides; Vasodilation; Vasodilator Agents | 2004 |
Atorvastatin reverses age-related reduction in rat hepatic PPARalpha and HNF-4.
Topics: Aging; Animals; Anticholesteremic Agents; Atorvastatin; Blood Glucose; Cholesterol Esters; Diet; DNA-Binding Proteins; Fatty Acids, Nonesterified; Female; Gene Expression Regulation; Heptanoic Acids; Lipid Metabolism; Liver; Liver X Receptors; Male; Orphan Nuclear Receptors; PPAR alpha; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sex Factors; Triglycerides | 2005 |
Immunohistochemical localization of advanced glycation end products in pinguecula.
Topics: Adult; Aged; Aging; Antibodies, Monoclonal; Arginine; Conjunctival Diseases; Female; Glycation End Products, Advanced; Humans; Imidazoles; Immunoenzyme Techniques; Lysine; Male; Middle Aged; Norleucine; Pyrroles | 2006 |
Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats.
Topics: Aging; Animals; Aromatase; Binding, Competitive; Cell Division; Cell Line, Tumor; Crystallography, X-Ray; Dihydrotestosterone; Epithelial Cells; Humans; Imidazoles; Ligands; Luteinizing Hormone; Male; Muscle, Skeletal; Orchiectomy; Prostate; Protein Structure, Tertiary; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Androgen; Testosterone; Transcription, Genetic | 2007 |
Atorvastatin slows down the deterioration of inner ear function with age in mice.
Topics: Acoustic Stimulation; Aging; Animals; Apolipoproteins E; Atorvastatin; Auditory Threshold; Dose-Response Relationship, Radiation; Ear, Inner; Food, Formulated; Gene Expression; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intercellular Adhesion Molecule-1; Mice; Mice, Inbred C57BL; Mice, Knockout; Otoacoustic Emissions, Spontaneous; Presbycusis; Pyrroles; Receptors, Vasopressin; Time Factors | 2007 |
Autophagic cell death, polyploidy and senescence induced in breast tumor cells by the substituted pyrrole JG-03-14, a novel microtubule poison.
Topics: Aging; Antineoplastic Agents; Autophagy; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Chromosome Aberrations; Drug Resistance, Neoplasm; Humans; Microtubules; Molecular Structure; Polyploidy; Pyrroles; Time Factors | 2007 |
Oxidative damage-induced inflammation initiates age-related macular degeneration.
Topics: Aging; Animals; Antibodies; Antigens; Bruch Membrane; Complement C3d; Immunization; Inflammation; Macular Degeneration; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oxidative Stress; Pigment Epithelium of Eye; Protein Transport; Pyrroles; Time Factors; Titrimetry | 2008 |
The selective alpha7 nicotinic acetylcholine receptor agonist A-582941 activates immediate early genes in limbic regions of the forebrain: Differential effects in the juvenile and adult rat.
Topics: Aging; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cytoskeletal Proteins; Genes, fos; Genes, Immediate-Early; Immunohistochemistry; In Situ Hybridization; Limbic System; Male; Nerve Tissue Proteins; Nicotinic Agonists; Prefrontal Cortex; Prosencephalon; Pyridazines; Pyrroles; Rats; Rats, Wistar; Receptors, Nicotinic; RNA, Messenger | 2008 |
Species and age-dependent differences of functional coupling between opioid delta-receptor and G-proteins and possible involvement of protein kinase C in striatal membranes.
Topics: Aging; Analgesics; Animals; Carbazoles; Cell Membrane; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Guinea Pigs; Indoles; Kinetics; Male; Naltrexone; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Species Specificity | 1994 |
Differential effects of hypoxia on electrical and mechanical activities of isolated ventricular muscles from fetal and adult guinea-pigs.
Topics: Action Potentials; Adenosine Triphosphate; Aging; Animals; Benzopyrans; Cromakalim; Depression, Chemical; Electrophysiology; Female; Guinea Pigs; Heart; Heart Ventricles; Hypoxia; In Vitro Techniques; Kinetics; Male; Myocardial Contraction; Potassium Channels; Pregnancy; Pyrroles; Ventricular Function | 1994 |
Immunoelectron microscopic analyses of Maillard reaction products in bovine anterior lens capsule and Descemet's membrane.
Topics: Aging; Animals; Basement Membrane; Carbohydrates; Cattle; Descemet Membrane; In Vitro Techniques; Lens Capsule, Crystalline; Maillard Reaction; Microscopy, Immunoelectron; Norleucine; Pyrroles | 1994 |
Age-related changes in endothelium-dependent hyperpolarization in the rat mesenteric artery.
Topics: Acetylcholine; Aging; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Electrophysiology; Endothelium, Vascular; Indomethacin; Male; Mesenteric Arteries; Norepinephrine; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation | 1993 |
Pyrraline ether crosslinks as a basis for protein crosslinking by the advanced Maillard reaction in aging and diabetes.
Topics: Aging; Amino Acids; Animals; Cross-Linking Reagents; Diabetes Mellitus; Ethers; Humans; Magnetic Resonance Spectroscopy; Maillard Reaction; Molecular Structure; Norleucine; Proteins; Pyrroles; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry | 1996 |
Age-related changes in response of brain stem vessels to opening of ATP-sensitive potassium channels.
Topics: Aging; Analysis of Variance; Animals; Antihypertensive Agents; Basilar Artery; Benzopyrans; Brain Stem; Cromakalim; Ion Channel Gating; Male; Muscle Development; Muscle, Smooth, Vascular; Nitroprusside; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 1997 |
Protein kinase C modulates ventilatory patterning in the developing rat.
Topics: Aging; Animals; Animals, Newborn; Blotting, Western; Brain Stem; Cerebral Cortex; Enzyme Inhibitors; Indoles; Plethysmography, Whole Body; Protein Kinase C; Pulmonary Ventilation; Pyrroles; Rats; Rats, Sprague-Dawley; Tidal Volume | 1999 |
Alterations in G-proteins and beta-adrenergic responsive adenylyl cyclase in rat urinary bladder during aging.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic beta-Agonists; Aging; Animals; Blotting, Western; Carbazoles; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; GTP-Binding Proteins; Indoles; Isoproterenol; Muscle, Smooth; Pertussis Toxin; Pyrroles; Rats; Receptors, Adrenergic, beta; Urinary Bladder; Virulence Factors, Bordetella | 2000 |
Activity-dependent presynaptic effect of serotonin 1B receptors on the somatosensory thalamocortical transmission in neonatal mice.
Topics: Aging; Animals; Animals, Newborn; Electric Stimulation; Excitatory Postsynaptic Potentials; In Vitro Techniques; Mice; Mice, Inbred Strains; Mice, Knockout; Neural Inhibition; Neurons; Patch-Clamp Techniques; Presynaptic Terminals; Pyridines; Pyrroles; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; RNA, Messenger; Serotonin; Serotonin Receptor Agonists; Somatosensory Cortex; Synaptic Transmission; Thalamus; Ventral Thalamic Nuclei | 2002 |
Alterations in proline metabolic enzymes with mammalian development.
Topics: Aging; Animals; Carboxylic Acids; Female; Kidney; Kinetics; Leucine; Liver; Mitochondria, Liver; Organ Specificity; Oxidoreductases; Oxygenases; Pregnancy; Proline; Pyrroles; Rats; Stereoisomerism; Valine | 1976 |
Pharmacokinetics of meropenem and its metabolite in young and elderly healthy men.
Topics: Adult; Aged; Aged, 80 and over; Aging; Humans; Infusions, Intravenous; Male; Meropenem; Pyrroles; Thienamycins | 1992 |
Age-related variations in tissue angiotensin converting enzyme activities: comparison between spontaneously hypertensive and Wistar-Kyoto rats.
Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Binding Sites; Fluorometry; Hypertension; Peptidyl-Dipeptidase A; Pyrroles; Ramipril; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin-Angiotensin System | 1990 |
Follow-up study of tolmetin users.
Topics: Adult; Aged; Aging; Female; Follow-Up Studies; Humans; Male; Middle Aged; Peptic Ulcer; Product Surveillance, Postmarketing; Pyrroles; Sex Factors; Tolmetin | 1989 |
Aging of proteins: immunological detection of a glucose-derived pyrrole formed during maillard reaction in vivo.
Topics: Aging; Enzyme-Linked Immunosorbent Assay; Glucose; Hydrogen-Ion Concentration; In Vitro Techniques; Maillard Reaction; Pyrroles; Serum Albumin, Bovine | 1989 |
Stimulation of the hexose monophosphate pathway by pyrroline-5-carboxylate reductase in the lens.
Topics: Aging; Animals; Female; Glucose; Glutamine; Lens, Crystalline; Male; Mice; Mice, Inbred Strains; Ornithine; Oxidoreductases Acting on CH-NH Group Donors; Pentose Phosphate Pathway; Proline; Pyrroles; Pyrroline Carboxylate Reductases; Rats; Rats, Inbred Strains | 1985 |
Uroporphyrinogen 3 cosynthetase in asymptomatic carriers of congenital erythpoietic porphyria.
Topics: Adolescent; Adult; Aging; Animals; Cattle; Erythrocyte Aging; Erythrocytes; Erythropoiesis; Female; Heterozygote; Humans; Isomerases; Male; Middle Aged; Porphyrias; Porphyrins; Propionates; Pyrroles | 1970 |