pyrazole has been researched along with Seizures in 6 studies
1H-pyrazole : The 1H-tautomer of pyrazole.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Ablation of TRPC3 lessens pilocarpine-induced seizures in mice, suggesting that TRPC3 inhibition might represent a novel antiseizure strategy." | 4.12 | Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects. ( Boda, VK; Hou, R; Jiang, J; Li, L; Li, W; Nagib, MM; Wu, Z; Yasmen, N; Yu, Y; Zhang, S, 2022) |
| " Alternating intraperitoneal injections of metabolically stable tert-butanol and ethanol for 4 consecutive days resulted in a physical dependence on alcohol, which was quantified by the latency and ED50 of picrotoxin-induced CNS hyperexcitability--myoclonic and tonic seizures and mortality--during the withdrawal period." | 3.67 | Increased sensitivity to picrotoxin as an index of physical dependence on alcohol in the mouse. ( Kovács, GL; Szabó, G; Telegdy, G, 1984) |
| "Withdrawal Seizure-Prone (WSP) and -Resistant (WSR) mice have been bidirectionally selected for severity of handling-induced convulsions (HIC) following withdrawal from 72 hr of chronic ethanol vapor inhalation." | 1.29 | Indexing withdrawal in mice: matching genotypes for exposure in studies using ethanol vapor inhalation. ( Crabbe, JC; Terdal, ES, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Nagib, MM | 1 |
| Zhang, S | 1 |
| Yasmen, N | 1 |
| Li, L | 1 |
| Hou, R | 1 |
| Yu, Y | 1 |
| Boda, VK | 1 |
| Wu, Z | 1 |
| Li, W | 1 |
| Jiang, J | 1 |
| Ahsan, MJ | 1 |
| Khalilullah, H | 1 |
| Stables, JP | 1 |
| Govindasamy, J | 1 |
| Guerrini, G | 1 |
| Ciciani, G | 1 |
| Cambi, G | 1 |
| Bruni, F | 1 |
| Selleri, S | 1 |
| Melani, F | 1 |
| Montali, M | 1 |
| Martini, C | 1 |
| Ghelardini, C | 1 |
| Norcini, M | 1 |
| Costanzo, A | 1 |
| Szabó, G | 1 |
| Kovács, GL | 1 |
| Telegdy, G | 1 |
| Crabbe, JC | 2 |
| Young, ER | 1 |
| Kosobud, A | 1 |
| Terdal, ES | 1 |
6 other studies available for pyrazole and Seizures
| Article | Year |
|---|---|
Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects.
Topics: Animals; Disease Models, Animal; Mice; Pentylenetetrazole; Pilocarpine; Pyrazoles; Seizures | 2022 |
Synthesis and anticonvulsant activity of 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues.
Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; Electroshock; Heterocyclic Compounds, 3-Ring | 2013 |
Novel 3-aroylpyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides 8-substituted, ligands at GABAA/benzodiazepine receptor complex: synthesis, pharmacological and molecular modeling studies.
Topics: Animals; Anxiety; Behavior, Animal; Ethanol; Ligands; Male; Memory; Models, Molecular; Molecular Str | 2008 |
Increased sensitivity to picrotoxin as an index of physical dependence on alcohol in the mouse.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Dose-Response Relationship, Drug; Humans; Lethal D | 1984 |
Genetic correlations with ethanol withdrawal severity.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Body Temperature Regulation; Drug Tolerance; Ethan | 1983 |
Indexing withdrawal in mice: matching genotypes for exposure in studies using ethanol vapor inhalation.
Topics: Administration, Inhalation; Alcohol Dehydrogenase; Alcohol Withdrawal Delirium; Animals; Dose-Respon | 1994 |