pyrazines and Glioma
pyrazines has been researched along with Glioma in 33 studies
Research
Studies (33)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (12.12) | 18.7374 |
| 1990's | 1 (3.03) | 18.2507 |
| 2000's | 6 (18.18) | 29.6817 |
| 2010's | 20 (60.61) | 24.3611 |
| 2020's | 2 (6.06) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Chen, Q; Gao, W; Ge, J; Liu, B; Liu, J; Tang, D; Yang, J; Zhao, J | 1 |
| Ang, BT; Cheng, HS; Chong, YK; Law, CLD; Low, ZYJ; Marvalim, C; Tan, NS; Tang, C; Zhu, P | 1 |
| Anjum, K; Chen, L; Lian, XY; Liang, Y; Zhang, X; Zhang, Z | 1 |
| Cai, X; Chen, P; Chen, Z; Ge, J; Georgakilas, AG; Hu, H; Pan, X; Tian, S; Xia, L; Yang, Y; Yu, K; Zhang, J; Zhuang, J | 1 |
| Alexandru, D; Bigner, D; Bota, DA; Friedman, HS; Keir, ST; Vredenburgh, J | 1 |
| Cao, Y; Farjam, R; Feng, FY; Gomez-Hassan, D; Hayman, JA; Lawrence, TS; Tsien, CI | 1 |
| Bergqvist, M; Bergström, S; Blomquist, E; Edqvist, PH; Ekman, S; Gullbo, J; Jaiswal, A; Johansson, M; Lennartsson, J; Navani, S; Pontén, F; Sooman, L; Tsakonas, G; Wu, X | 1 |
| Benes, CH; Bersani, F; Boussin, FD; Bryll, AR; Cox, KE; Flynn, RL; Ganem, NJ; Haber, DA; Jeitany, M; Pineda, JR; Suvà, ML; Wakimoto, H; Zou, L | 1 |
| Baryawno, N; Calero, R; Darabi, A; Dyberg, C; Einvik, C; Johnsen, JI; Kogner, P; Kool, M; Milosevic, J; Sandén, E; Siesjö, P; Sveinbjörnsson, B; Wickström, M | 1 |
| de Jong, S; de Vries, EG; Oldenhuis, CN; Stegehuis, JH; Walenkamp, AM | 1 |
| Chastagner, P; Delfortrie, S; Labussiere, M; Pinel, S; Plenat, F | 1 |
| Shiguang, Z; Tianhu, Z; Xinghan, L | 1 |
| Burt Nabors, L; Carson, KA; Desideri, S; Grossman, SA; Lesser, G; Mikkelsen, T; Olson, JJ; Phuphanich, S; Rosenfeld, S; Supko, JG | 1 |
| Chastagner, P; Labussière, M; Pinel, S; Plénat, F; Vandamme, M | 1 |
| Jane, EP; Pollack, IF; Premkumar, DR | 1 |
| Bota, DA; Gong, X; Linskey, ME; Schwartz, PH | 1 |
| Brodie, C; Brodie, S; Cazacu, S; Finniss, S; Goldstein, RS; Kahana, S; Lee, HK; Mikkelsen, T; Roitman, V; Slavin, S; Xiang, C | 1 |
| Balyasnikova, IV; Ferguson, SD; Han, Y; Lesniak, MS; Liu, F | 1 |
| Agostino, NR; DiDomenico, JD; Jane, EP; Pollack, IF; Premkumar, DR | 1 |
| Seol, DW | 1 |
| Bovenberg, MS; Degeling, MH; Tannous, BA | 1 |
| Agostino, NR; DiDomenico, JD; Jane, EP; Pollack, IF; Premkumar, DR; Vukmer, NA | 1 |
| Ambati, B; Chen, Z; Ge, J; Pan, X; Tian, S; Yang, Y; Yu, K; Zhang, J; Zhuang, J | 1 |
| Brodie, C; Brodie, S; Cazacu, S; Finniss, SA; Kazimirsky, G; Lee, HK; Lemke, N; Margel, S; Mikklesen, T; Miller, C; Okhrimenko, H; Perlstein, B; Rempel, SA; Rosenblum, M; Umansky, F | 1 |
| Fine, H; Hess, K; Jaeckle, K; Kunschner, LJ; Kyritsis, AP; Yung, WK | 1 |
| Cao, Y; Contag, CH; Doyle, TC; Piwnica-Worms, D; Stevenson, DK; Wong, RJ; Zhao, H | 1 |
| Cheng, FC; Cheng, H; Chou, SC; Fu, YS; Fu, YY; Hsu, SY; Kao, LS; Lin, YY; Shih, YH; Tsai, TH; Wang, JY | 1 |
| Adjei, AA; Atadja, P; Friday, BB; Sarkaria, J; Wigle, D; Yang, L; Yu, C | 1 |
| Benos, DJ; Sapirstein, VS | 2 |
| Cragoe, E; O'Donnell, ME; Villereal, ML | 1 |
| O'Donnell, ME; Villereal, ML | 1 |
| Adachi, M; Hori, T; Kawai, K; Nakai, S; Tanaka, S | 1 |
Reviews
1 review(s) available for pyrazines and Glioma
| Article | Year |
|---|---|
Targeting TRAIL death receptors.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Boronic Acids; Bortezomib; Brain Neoplasms; Glioma; HLA-DR4 Antigen; HLA-DR5 Antigen; Humans; Neoplasms; Pyrazines; Receptors, Death Domain; Receptors, TNF-Related Apoptosis-Inducing Ligand | 2008 |
Trials
2 trial(s) available for pyrazines and Glioma
| Article | Year |
|---|---|
Phase 1 clinical trial of bortezomib in adults with recurrent malignant glioma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Boronic Acids; Bortezomib; Brain Neoplasms; Dose-Response Relationship, Drug; Female; Glioma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Proteasome Endopeptidase Complex; Pyrazines; Treatment Outcome | 2010 |
CI-980 for the treatment of recurrent or progressive malignant gliomas: national central nervous system consortium phase I-II evaluation of CI-980.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Carbamates; Disease-Free Survival; Female; Glioma; Humans; Infusions, Intravenous; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Pyrazines; Pyridines; Survival Rate; Thrombocytopenia; Treatment Outcome | 2002 |
Other Studies
30 other study(ies) available for pyrazines and Glioma
| Article | Year |
|---|---|
miR‑181d promotes cell proliferation via the IGF1/PI3K/AKT axis in glioma.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Glioma; Humans; Imidazoles; Insulin-Like Growth Factor I; Male; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazines; Signal Transduction; Transfection; Tumor Burden; Xenograft Model Antitumor Assays | 2020 |
Kinomic profile in patient-derived glioma cells during hypoxia reveals c-MET-PI3K dependency for adaptation.
Topics: Animals; Antioxidants; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Glioma; Humans; Hypoxia; Male; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-met; Pyrazines; Pyrrolidinones; Quinolines; Signal Transduction; Temozolomide; Transcriptome; Triazoles | 2021 |
Bioactive Bafilomycins and a New N-Arylpyrazinone Derivative from Marine-derived Streptomyces sp. HZP-2216E.
Topics: Anti-Infective Agents; Cell Line, Tumor; Cell Proliferation; Glioma; Humans; Macrolides; Magnetic Resonance Spectroscopy; Methicillin-Resistant Staphylococcus aureus; Pyrazines; Streptomyces; Ulva | 2017 |
Tetramethylpyrazine (TMP) protects cerebral neurocytes and inhibits glioma by down regulating chemokine receptor CXCR4 expression.
Topics: Animals; Apoptosis; Brain Neoplasms; Calcium; Cell Line, Tumor; Cell Movement; Chemokine CXCL12; Down-Regulation; Glioma; Hydrogen Peroxide; Neurons; Pyrazines; Rats; Receptors, CXCR4 | 2013 |
Proteasome inhibition with bortezomib induces cell death in GBM stem-like cells and temozolomide-resistant glioma cell lines, but stimulates GBM stem-like cells' VEGF production and angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Bevacizumab; Boronic Acids; Bortezomib; Caspase 3; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Drug Therapy, Combination; Glioblastoma; Glioma; Humans; Male; Mice; Mice, Inbred BALB C; Neoplastic Stem Cells; Neovascularization, Pathologic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Temozolomide; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2013 |
Investigation of the diffusion abnormality index as a new imaging biomarker for early assessment of brain tumor response to radiation therapy.
Topics: Adult; Aged; Antineoplastic Agents; Biomarkers; Boronic Acids; Bortezomib; Brain Neoplasms; Chemoradiotherapy; Cranial Irradiation; Diffusion Magnetic Resonance Imaging; Female; Follow-Up Studies; Glioma; Humans; Male; Middle Aged; Neoplasm Staging; Prognosis; Prospective Studies; Pyrazines; Radiation-Sensitizing Agents | 2014 |
PTPN6 expression is epigenetically regulated and influences survival and response to chemotherapy in high-grade gliomas.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Autophagy; Boronic Acids; Bortezomib; Brain Neoplasms; Cell Line, Tumor; DNA Methylation; Epigenesis, Genetic; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Grading; Prognosis; Promoter Regions, Genetic; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Pyrazines | 2014 |
Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors.
Topics: Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Line, Tumor; DNA Helicases; Gene Knockdown Techniques; Glioma; HeLa Cells; Homologous Recombination; Humans; Nuclear Proteins; Osteosarcoma; Promyelocytic Leukemia Protein; Pyrazines; Replication Protein A; RNA, Untranslated; Sulfones; Telomerase; Telomere; Telomere Homeostasis; Telomeric Repeat Binding Protein 2; Transcription Factors; Tumor Suppressor Proteins; X-linked Nuclear Protein | 2015 |
Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance.
Topics: Animals; Antineoplastic Agents; Benzeneacetamides; beta Catenin; Brain Neoplasms; Camptothecin; Celecoxib; Cisplatin; Colorectal Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Doxorubicin; Drug Resistance, Neoplasm; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Glucose-6-Phosphate Isomerase; Heterocyclic Compounds, 3-Ring; Humans; Immunoblotting; Immunohistochemistry; Irinotecan; Medulloblastoma; Mice; Neoplasm Transplantation; Neoplasms; Neuroblastoma; Pyrans; Pyrazines; Pyridines; Real-Time Polymerase Chain Reaction; Sulfones; Temozolomide; Triazoles; Tumor Suppressor Proteins; Vincristine; Wnt Proteins; Wnt Signaling Pathway | 2015 |
Proteasome inhibition by bortezomib does not translate into efficacy on two malignant glioma xenografts.
Topics: Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Female; Glioma; Humans; Mice; Mice, Nude; Proteasome Endopeptidase Complex; Pyrazines; Xenograft Model Antitumor Assays | 2008 |
Bmf is upregulated by PS-341-mediated cell death of glioma cells through JNK phosphorylation.
Topics: Adaptor Proteins, Signal Transducing; Analysis of Variance; Antineoplastic Agents; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cell Line, Tumor; DNA Fragmentation; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glioma; Humans; MAP Kinase Kinase 4; Phosphorylation; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Tetrazolium Salts; Thiazoles | 2010 |
Radiosensitizing properties of bortezomib depend on therapeutic schedule.
Topics: Animals; Apoptosis; Boronic Acids; Bortezomib; Cell Cycle; Cell Proliferation; Combined Modality Therapy; Dose Fractionation, Radiation; Drug Administration Schedule; Female; Glioma; Mice; Mice, Nude; NF-kappa B; Pyrazines; Radiation Tolerance; Radiation-Sensitizing Agents; Random Allocation; Xenograft Model Antitumor Assays | 2011 |
Bortezomib sensitizes malignant human glioma cells to TRAIL, mediated by inhibition of the NF-{kappa}B signaling pathway.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Growth Processes; Cell Line, Tumor; DNA, Neoplasm; Drug Synergism; Gene Knockdown Techniques; Glioma; Humans; NF-kappa B; Pyrazines; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA, Small Interfering; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Transcription Factor RelA; Transfection | 2011 |
Neural stem/progenitors and glioma stem-like cells have differential sensitivity to chemotherapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Cisplatin; Dacarbazine; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression; Glioma; Humans; Neoplastic Stem Cells; Neural Stem Cells; Protein Kinase Inhibitors; Pyrazines; Quinazolines; Temozolomide | 2011 |
Proteasome inhibitors sensitize glioma cells and glioma stem cells to TRAIL-induced apoptosis by PKCε-dependent downregulation of AKT and XIAP expressions.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Astrocytes; Boronic Acids; Bortezomib; Cell Line, Tumor; Down-Regulation; Glioma; Humans; Leupeptins; Mutagenesis, Site-Directed; Neoplastic Stem Cells; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinase C-epsilon; Proto-Oncogene Proteins c-akt; Pyrazines; TNF-Related Apoptosis-Inducing Ligand; X-Linked Inhibitor of Apoptosis Protein | 2011 |
Therapeutic effect of neural stem cells expressing TRAIL and bortezomib in mice with glioma xenografts.
Topics: Animals; Boronic Acids; Bortezomib; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Glioma; HEK293 Cells; Humans; Immunohistochemistry; Jurkat Cells; Male; Mice; Mice, Nude; Neural Stem Cells; Protease Inhibitors; Pyrazines; Stem Cell Transplantation; TNF-Related Apoptosis-Inducing Ligand; Xenograft Model Antitumor Assays | 2011 |
Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; Boronic Acids; Bortezomib; Cell Line, Tumor; Central Nervous System Neoplasms; Cytochromes c; DNA Damage; Glioblastoma; Glioma; Histones; Humans; Hydroxamic Acids; Membrane Potential, Mitochondrial; Membrane Proteins; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Proteasome Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Reactive Oxygen Species; Tumor Cells, Cultured; Vorinostat | 2013 |
p53-Independent up-regulation of a TRAIL receptor DR5 by proteasome inhibitors: a mechanism for proteasome inhibitor-enhanced TRAIL-induced apoptosis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Brain Neoplasms; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Glioma; Humans; Leupeptins; Proteasome Inhibitors; Pyrazines; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand; Tumor Suppressor Protein p53; Up-Regulation | 2011 |
Enhanced Gaussia luciferase blood assay for monitoring of in vivo biological processes.
Topics: Animals; Copepoda; Genes, Reporter; Glioma; Humans; Imidazoles; Luciferases; Luminescent Measurements; Mice; Mice, Nude; Pyrazines; Tumor Cells, Cultured | 2012 |
ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines.
Topics: Annexins; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Biphenyl Compounds; Blotting, Western; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Glioma; Humans; Mitochondrial Diseases; NF-kappa B; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-akt; Pyrazines; Sulfonamides | 2012 |
Tetramethylpyrazine-mediated suppression of C6 gliomas involves inhibition of chemokine receptor CXCR4 expression.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Survival; Gene Expression; Glioma; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; Remission Induction; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
TRAIL conjugated to nanoparticles exhibits increased anti-tumor activities in glioma cells and glioma stem cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cell Proliferation; Combined Modality Therapy; Female; Ferric Compounds; Gamma Rays; Glioma; Humans; Immunoenzyme Techniques; In Vitro Techniques; Nanoparticles; Neoplastic Stem Cells; Pyrazines; Rats; Rats, Nude; Recombinant Proteins; Survival Rate; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2013 |
Characterization of coelenterazine analogs for measurements of Renilla luciferase activity in live cells and living animals.
Topics: Animals; Anthozoa; Cell Line, Tumor; Dose-Response Relationship, Drug; Genes, Reporter; Glioma; HeLa Cells; Humans; Imidazoles; Injections, Intravenous; Kinetics; Luciferases; Luminescent Measurements; Male; Mice; Mice, Inbred Strains; Molecular Structure; Protein Binding; Pyrazines; Radionuclide Imaging; Rats; Substrate Specificity; Time Factors; Transfection | 2004 |
Tetramethylpyrazine inhibits activities of glioma cells and glutamate neuro-excitotoxicity: potential therapeutic application for treatment of gliomas.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Coculture Techniques; Glioma; Glutamic Acid; Microdialysis; Nerve Degeneration; Neurons; Pyrazines; Rats; Rats, Sprague-Dawley; Xenograft Model Antitumor Assays | 2008 |
Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Boronic Acids; Bortezomib; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Glioma; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Indoles; Mitochondria; Panobinostat; Proteasome Inhibitors; Protein Transport; Pyrazines; RNA, Small Interfering | 2008 |
Activation of amiloride-sensitive sodium transport in C6 glioma cells.
Topics: Amiloride; Animals; Biological Transport, Active; Bradykinin; Bucladesine; Cell Line; Colchicine; Diglycerides; Epidermal Growth Factor; Glioma; Protons; Pyrazines; Rats; Sodium; Tetradecanoylphorbol Acetate | 1984 |
Characteristics of an amiloride-sensitive sodium entry pathway in cultured rodent glial and neuroblastoma cells.
Topics: Amiloride; Animals; Biological Transport; Blood; Calcimycin; Cell Division; Cell Line; Cycloheximide; Dose-Response Relationship, Drug; Fenfluramine; Glioma; Kinetics; Mice; Neuroblastoma; Neurons; Pyrazines; Rats; Sodium | 1983 |
Inhibition of Na+ influx and DNA synthesis in human fibroblasts and neuroblastoma-glioma hybrid cells by amiloride analogs.
Topics: Amiloride; Animals; Cell Line; DNA Replication; Fibroblasts; Glioma; Humans; Hybrid Cells; Neuroblastoma; Pyrazines; Sodium | 1983 |
Membrane potential and sodium flux in neuroblastoma X glioma hybrid cells: effects of amiloride and serum.
Topics: Amiloride; Animals; Blood; Cell Line; Dose-Response Relationship, Drug; Glioma; Hybrid Cells; Membrane Potentials; Mice; Neuroblastoma; Pyrazines; Rats; Sodium; Thymidine | 1982 |
Apoptosis-inducing activity and growth suppression by vesnarinone on human glioma transplanted in nude mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Dose-Response Relationship, Drug; Drug Administration Routes; Glioma; Graft Survival; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Pyrazines; Quinolines; Tumor Cells, Cultured | 1999 |