Page last updated: 2024-08-21

pyrazines and Anxiety

pyrazines has been researched along with Anxiety in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.56)18.7374
1990's2 (11.11)18.2507
2000's6 (33.33)29.6817
2010's8 (44.44)24.3611
2020's1 (5.56)2.80

Authors

AuthorsStudies
Cai, S; Chew, LA; Jiang, Y; Jin, Y; Khanna, R; Ruan, Y; Wen, C; Xu, Z; Yu, J; Zhong, K1
Arihara, K; Ohata, M; Yada, Y; Yokoyama, I; Zhou, L1
de Andrade, TGCS; Hernandes, PM; Sant'Ana, AB; Vicente, MA; Vilela-Costa, HH; Zangrossi, H1
Vicente, MA; Zangrossi, H1
Bègue, L; Bell, R; Duke, AA; Gilmore, PE; Page, D1
Bates, BS; Blobaum, AL; Byers, FW; Conn, PJ; Daniels, JS; Emmitte, KA; Felts, AS; Jones, CK; Lawson, KP; Lindsley, CW; Morrison, RD; Niswender, CM; Rodriguez, AL; Venable, DF1
Der-Ghazarian, T; Neisewander, JL; Pentkowski, NS; Pockros-Burgess, LA1
Deeva, OA; Gudasheva, TA; Mokrov, GV; Seredenin, SB; Yarkov, SA; Yarkova, MA1
Fleshner, M; Greenwood, BN; Strong, PV1
Eller, M; Foreman, MM; Hanania, T1
Gomes, KS; Nunes-De-Souza, RL1
Buell, DR; Dine, J; Eder, M; Herrmann, L; Holsboer, F; Ionescu, IA; Landgraf, R; Schmidt, U; Yen, YC1
Combs, AP; Dzierba, CD; Gilligan, PJ; Kasireddy-Polam, P; Lelas, S; Li, YW; McElroy, JF; Molski, TF; Peng, Y; Rafalski, M; Takvorian, AG; Taub, RA; Trainor, GL; Wong, H; Zaczek, RC; Zhang, G1
Davis, M; Donovan, JL; Hamdy, FC; Lane, JA; Metcalfe, C; Mills, N; Neal, DE; Peters, TJ; Ronsmans, C; Sterne, JA1
Amstislavskaya, TG; Bulygina, VV; Kuznetsova, EG; Popova, NK; Tibeikina, MA1
Caignard, DH; Delagrange, P; Guardiola-Lemaitre, B; Hamon, M; Lancelot, JC; Misslin, R; Pfeiffer, B; Prunier, H; Rault, S; Renard, P; Robba, M1
Delagrange, P; Misslin, R; Pfeiffer, B; Rault, S; Renard, P; Seale, TW1
Al-Shaltchi, B; Brändli, A; Fleischhauer, J1

Other Studies

18 other study(ies) available for pyrazines and Anxiety

ArticleYear
Tetramethylpyrazine Reduces Epileptogenesis Progression in Electrical Kindling Models by Modulating Hippocampal Excitatory Neurotransmission.
    ACS chemical neuroscience, 2019, 12-18, Volume: 10, Issue:12

    Topics: Animals; Anticonvulsants; Anxiety; CA1 Region, Hippocampal; Calcium Channel Blockers; Calcium Channels; Convulsants; Disease Progression; Electric Stimulation; Electroshock; Epilepsy, Complex Partial; Excitatory Postsynaptic Potentials; Exploratory Behavior; Ion Transport; Kindling, Neurologic; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Neural Pathways; Pentylenetetrazole; Pyrazines; Recognition, Psychology; Seizures; Sodium Channels

2019
2,3-Dimethylpyrazine (3DP) and 2,5-dimethyl-4-hydroxy-3(2
    Bioscience, biotechnology, and biochemistry, 2020, Volume: 84, Issue:9

    Topics: Anger; Anxiety; Autonomic Nervous System; Central Nervous System; Female; Food; Furans; Glucose; Glycine; Humans; Maillard Reaction; Male; Odorants; Pyrazines; Young Adult

2020
Role of 5-HT2C receptors of the dorsal hippocampus in the modulation of anxiety- and panic-related defensive responses in rats.
    Neuropharmacology, 2019, Volume: 148

    Topics: Aminopyridines; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Ethylamines; Hippocampus; Imipramine; Indoles; Male; Maze Learning; Microinjections; Panic; Piperazines; Punishment; Pyrazines; Rats; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists

2019
Involvement of 5-HT2C and 5-HT1A receptors of the basolateral nucleus of the amygdala in the anxiolytic effect of chronic antidepressant treatment.
    Neuropharmacology, 2014, Volume: 79

    Topics: Amygdala; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Anxiety; Avoidance Learning; Exploratory Behavior; Fluoxetine; Imipramine; Male; Maze Learning; Panic; Piperazines; Pyrazines; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Agonists

2014
Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT2/5-HT3/5-HT4 ligands.
    Scientific reports, 2014, Jan-24, Volume: 4

    Topics: Aniline Compounds; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Diazepam; Male; Maze Learning; Oxazines; Piperidines; Propane; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sulfonamides

2014
Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.
    Bioorganic & medicinal chemistry letters, 2014, Aug-01, Volume: 24, Issue:15

    Topics: Allosteric Site; Animals; Anxiety; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Humans; Male; Mice; Molecular Structure; Picolinic Acids; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Structure-Activity Relationship

2014
Effects of the 5-HT2C receptor agonist CP809101 in the amygdala on reinstatement of cocaine-seeking behavior and anxiety-like behavior.
    The international journal of neuropsychopharmacology, 2014, Volume: 17, Issue:11

    Topics: Aminopyridines; Amygdala; Animals; Anxiety; Cocaine; Conditioning, Operant; Cues; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Drug-Seeking Behavior; Extinction, Psychological; Indoles; Male; Maze Learning; Piperazines; Pyrazines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Serotonin 5-HT2 Receptor Agonists

2014
Design, synthesis and anxiolytic-like activity of 1-arylpyrrolo[1,2-a]pyrazine-3-carboxamides.
    Bioorganic & medicinal chemistry, 2015, Jul-01, Volume: 23, Issue:13

    Topics: Amides; Animals; Anti-Anxiety Agents; Anxiety; Binding Sites; Diazepam; Dose-Response Relationship, Drug; Drug Design; Gene Expression; Isoquinolines; Ligands; Male; Maze Learning; Mice; Mice, Inbred BALB C; Motor Activity; Protein Binding; Pyrazines; Receptors, GABA; Structure-Activity Relationship

2015
The effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats.
    Psychopharmacology, 2009, Volume: 203, Issue:4

    Topics: Aminopyridines; Animals; Anxiety; Escape Reaction; Freezing Reaction, Cataleptic; Helplessness, Learned; Indoles; Injections, Intraperitoneal; Male; Piperazines; Pyrazines; Rats; Rats, Inbred F344; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Stress, Psychological

2009
Anxiolytic effects of lamotrigine and JZP-4 in the elevated plus maze and in the four plate conflict test.
    European journal of pharmacology, 2009, Jan-14, Volume: 602, Issue:2-3

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Lamotrigine; Male; Maze Learning; Mice; Punishment; Pyrazines; Triazines

2009
Implication of the 5-HT2A and 5-HT2C (but not 5HT1A) receptors located within the periaqueductal gray in the elevated plus-maze test-retest paradigm in mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2009, Oct-01, Volume: 33, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Mice; Microinjections; Motor Activity; Periaqueductal Gray; Pyrazines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Reproducibility of Results; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT2 Receptor Agonists; Serotonin Agents

2009
Intranasally administered neuropeptide S (NPS) exerts anxiolytic effects following internalization into NPS receptor-expressing neurons.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012, Volume: 37, Issue:6

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; CA1 Region, Hippocampal; Carbocyanines; Cell Line, Transformed; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiology; Evoked Potentials; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Humans; In Vitro Techniques; Intravitreal Injections; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neurofilament Proteins; Neurons; Neuropeptides; Oxazolidinones; Protein Transport; Pyrazines; Receptors, AMPA; Receptors, Neuropeptide; Rhodamines; RNA, Messenger; Synapsins; Transfection

2012
Synthesis, structure-activity relationships, and in vivo properties of 3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-ones as corticotropin-releasing factor-1 receptor antagonists.
    Journal of medicinal chemistry, 2004, Nov-04, Volume: 47, Issue:23

    Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Binding, Competitive; Dogs; Frontal Lobe; Half-Life; In Vitro Techniques; Male; Pyrazines; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Corticotropin-Releasing Hormone; Structure-Activity Relationship

2004
A comparison of socio-demographic and psychological factors between patients consenting to randomisation and those selecting treatment (the ProtecT study).
    Contemporary clinical trials, 2006, Volume: 27, Issue:5

    Topics: Aged; Anxiety; Depression; Follow-Up Studies; Humans; Hydrazines; Male; Middle Aged; Patient Satisfaction; Patient Selection; Prostatic Neoplasms; Pyrazines; Quinolines; Randomized Controlled Trials as Topic; Socioeconomic Factors

2006
Effect of 5HT2C-receptor agonist MK-212 on blood corticosterone level and behavior in mice.
    Bulletin of experimental biology and medicine, 2006, Volume: 142, Issue:5

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression, Chemical; Male; Mice; Mice, Inbred CBA; Motor Activity; Pyrazines; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists

2006
Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines.
    Journal of medicinal chemistry, 1997, Jun-06, Volume: 40, Issue:12

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Cattle; Cell Membrane; Corpus Striatum; Darkness; Frontal Lobe; Guanidine; Guanidines; Hippocampus; Light; Male; Molecular Structure; Pyrazines; Pyridines; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Receptor Agonists; Structure-Activity Relationship; Swine

1997
Effects of S-21007, a potent 5-HT3 partial agonist, in mouse anxiety.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1999, Volume: 20, Issue:9

    Topics: Animals; Anxiety; Behavior, Animal; Male; Mice; Mice, Inbred BALB C; Piperazines; Pyrazines; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Receptor Agonists

1999
[Report on a preliminary open clinical study of mianserin (GB 94), a tetracyclic antidepressant].
    Arzneimittel-Forschung, 1973, Volume: 23, Issue:12

    Topics: Adult; Aged; Animals; Antidepressive Agents; Anxiety; Azepines; Bipolar Disorder; Conflict, Psychological; Depression; Depressive Disorder, Major; Dopamine Antagonists; Electroencephalography; Feeding and Eating Disorders; Female; Humans; Mental Fatigue; Mice; Middle Aged; Pyrazines; Rats; Serologic Tests; Sleep Wake Disorders

1973