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propofol and Encephalopathy, Hepatic

propofol has been researched along with Encephalopathy, Hepatic in 14 studies

Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"Propofol-based sedation exacerbated MHE after EIS similarly to midazolam-based sedation in patients with liver cirrhosis."9.27Propofol is a more effective and safer sedative agent than midazolam in endoscopic injection sclerotherapy for esophageal varices in patients with liver cirrhosis: a randomized controlled trial. ( Hashimoto, M; Hikichi, T; Irie, H; Kikuchi, H; Konno, N; Nakamura, J; Obara, K; Ohira, H; Sato, Y; Sugimoto, M; Suzuki, R; Takagi, T; Takasumi, M; Watanabe, K, 2018)
"Our study aimed to investigate the effects of propofol medium and long chain lipid emulsion on cognitive function of the patients with hepatic encephalopathy undergoing hemofiltration treatment."9.24Effects on cognitive function of propofol medium and long chain lipid emulsion in patients with hepatic encephalopathy. ( Ding, L; Hu, J; Yu, D; Yu, S, 2017)
"Sedation with propofol has a shorter time recovery and a shorter time to discharge than midazolam and does not exacerbate sub-clinical hepatic encephalopathy in patients with compensated liver cirrhosis."9.15Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam: a randomized controlled study. ( Alex, I; Kamal, D; Khamaysi, I; Nimer, A; Olga, A; Vladimir, M; William, N, 2011)
"Midazolam sedation for upper gastrointestinal (GI) endoscopy exacerbates minimal hepatic encephalopathy (HE) in patients with liver cirrhosis, therefore an alternative drug regimen for these patients is warranted."9.14Propofol sedation for upper gastrointestinal endoscopy in patients with liver cirrhosis as an alternative to midazolam to avoid acute deterioration of minimal encephalopathy: a randomized, controlled study. ( Frenz, MB; Lechowicz, I; Riphaus, A; Wehrmann, T, 2009)
"The risk of hepatic encephalopathy (HE) precipitated by propofol has not been established."7.75Deep sedation with propofol does not precipitate hepatic encephalopathy during elective upper endoscopy. ( Amorós, A; Aparicio, JR; Casellas, JA; Garmendia, M; Jover, R; Martínez, J, 2009)
"Propofol-based sedation exacerbated MHE after EIS similarly to midazolam-based sedation in patients with liver cirrhosis."5.27Propofol is a more effective and safer sedative agent than midazolam in endoscopic injection sclerotherapy for esophageal varices in patients with liver cirrhosis: a randomized controlled trial. ( Hashimoto, M; Hikichi, T; Irie, H; Kikuchi, H; Konno, N; Nakamura, J; Obara, K; Ohira, H; Sato, Y; Sugimoto, M; Suzuki, R; Takagi, T; Takasumi, M; Watanabe, K, 2018)
"Our study aimed to investigate the effects of propofol medium and long chain lipid emulsion on cognitive function of the patients with hepatic encephalopathy undergoing hemofiltration treatment."5.24Effects on cognitive function of propofol medium and long chain lipid emulsion in patients with hepatic encephalopathy. ( Ding, L; Hu, J; Yu, D; Yu, S, 2017)
" Baseline psychomotor performance was more impaired in cirrhotic patients, but propofol was not associated with deteriorated psychomotor function even in cirrhotic patients with a minimal hepatic encephalopathy."5.19Is propofol safe when administered to cirrhotic patients during sedative endoscopy? ( Byun, KS; Choi, JH; Choung, RS; Hyun, JJ; Jung, SW; Kim, JH; Kim, KJ; Koo, JS; Lee, BJ; Lee, SW; Ryu, HS; Seo, YS; Suh, SJ; Um, SH; Yeon, JE; Yim, HJ; Yoon, EL, 2014)
"Sedation with propofol has a shorter time recovery and a shorter time to discharge than midazolam and does not exacerbate sub-clinical hepatic encephalopathy in patients with compensated liver cirrhosis."5.15Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam: a randomized controlled study. ( Alex, I; Kamal, D; Khamaysi, I; Nimer, A; Olga, A; Vladimir, M; William, N, 2011)
"Midazolam sedation for upper gastrointestinal (GI) endoscopy exacerbates minimal hepatic encephalopathy (HE) in patients with liver cirrhosis, therefore an alternative drug regimen for these patients is warranted."5.14Propofol sedation for upper gastrointestinal endoscopy in patients with liver cirrhosis as an alternative to midazolam to avoid acute deterioration of minimal encephalopathy: a randomized, controlled study. ( Frenz, MB; Lechowicz, I; Riphaus, A; Wehrmann, T, 2009)
"The risk of hepatic encephalopathy (HE) precipitated by propofol has not been established."3.75Deep sedation with propofol does not precipitate hepatic encephalopathy during elective upper endoscopy. ( Amorós, A; Aparicio, JR; Casellas, JA; Garmendia, M; Jover, R; Martínez, J, 2009)
"Midazolam was associated with the deterioration of psychometric scores for a longer period than propofol."2.52Propofol versus midazolam for upper gastrointestinal endoscopy in cirrhotic patients: a meta-analysis of randomized controlled trials. ( Chen, CY; Chen, TL; Ko, CL; Lin, YC; Lou, HY; Tam, KW; Tsai, HC, 2015)
"Hepatic encephalopathy is a neurologic syndrome secondary to liver failure that causes cognitive and motor abnormalities."1.33Functional abnormalities of the motor tract in the rat after portocaval anastomosis and after carbon tetrachloride induction of cirrhosis. ( Bartolí, R; Chatauret, N; Córdoba, J; Odena, G; Oria, M; Planas, R; Raguer, N, 2006)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's4 (28.57)29.6817
2010's8 (57.14)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Jeong, J1
Jung, K1
Seo, KI1
Yun, BC1
Han, BH1
Lee, SU1
Moon, W1
Yu, S1
Hu, J1
Ding, L1
Yu, D1
Watanabe, K1
Hikichi, T1
Takagi, T1
Suzuki, R1
Nakamura, J1
Sugimoto, M1
Kikuchi, H1
Konno, N1
Takasumi, M1
Sato, Y1
Hashimoto, M1
Irie, H1
Obara, K1
Ohira, H1
Suh, SJ1
Yim, HJ1
Yoon, EL1
Lee, BJ1
Hyun, JJ1
Jung, SW1
Koo, JS1
Kim, JH1
Kim, KJ1
Choung, RS1
Seo, YS1
Yeon, JE1
Um, SH1
Byun, KS1
Lee, SW1
Choi, JH1
Ryu, HS1
Tsai, HC1
Lin, YC1
Ko, CL1
Lou, HY1
Chen, TL1
Tam, KW1
Chen, CY1
Amorós, A1
Aparicio, JR1
Garmendia, M1
Casellas, JA1
Martínez, J1
Jover, R1
Riphaus, A1
Lechowicz, I1
Frenz, MB1
Wehrmann, T1
Khamaysi, I1
William, N1
Olga, A1
Alex, I1
Vladimir, M1
Kamal, D1
Nimer, A1
Okawa, H1
Ono, T1
Hashiba, E1
Tsubo, T1
Ishihara, H1
Hirota, K1
Sharma, P2
Singh, S2
Sharma, BC2
Kumar, M1
Garg, H1
Kumar, A1
Sarin, SK1
Oria, M1
Raguer, N1
Chatauret, N1
Bartolí, R1
Odena, G1
Planas, R1
Córdoba, J1
Braunfeld, MY1
Wijdicks, EF1
Nyberg, SL1

Reviews

1 review available for propofol and Encephalopathy, Hepatic

ArticleYear
Propofol versus midazolam for upper gastrointestinal endoscopy in cirrhotic patients: a meta-analysis of randomized controlled trials.
    PloS one, 2015, Volume: 10, Issue:2

    Topics: Anesthesia Recovery Period; Bradycardia; Deep Sedation; Endoscopy, Gastrointestinal; Fibrosis; Hepat

2015

Trials

7 trials available for propofol and Encephalopathy, Hepatic

ArticleYear
Effects on cognitive function of propofol medium and long chain lipid emulsion in patients with hepatic encephalopathy.
    Panminerva medica, 2017, Volume: 59, Issue:4

    Topics: Aged; Biomarkers; China; Cognition; Drug Compounding; Fat Emulsions, Intravenous; Female; Hemofiltra

2017
Propofol is a more effective and safer sedative agent than midazolam in endoscopic injection sclerotherapy for esophageal varices in patients with liver cirrhosis: a randomized controlled trial.
    Fukushima journal of medical science, 2018, Dec-08, Volume: 64, Issue:3

    Topics: Aged; Esophageal and Gastric Varices; Female; Hepatic Encephalopathy; Humans; Hypnotics and Sedative

2018
Is propofol safe when administered to cirrhotic patients during sedative endoscopy?
    The Korean journal of internal medicine, 2014, Volume: 29, Issue:1

    Topics: Adult; Endoscopy, Gastrointestinal; Female; Hepatic Encephalopathy; Humans; Hypnotics and Sedatives;

2014
Propofol sedation for upper gastrointestinal endoscopy in patients with liver cirrhosis as an alternative to midazolam to avoid acute deterioration of minimal encephalopathy: a randomized, controlled study.
    Scandinavian journal of gastroenterology, 2009, Volume: 44, Issue:10

    Topics: Aged; Endoscopy, Gastrointestinal; Esophageal and Gastric Varices; Female; Hepatic Encephalopathy; H

2009
Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam: a randomized controlled study.
    Journal of hepatology, 2011, Volume: 54, Issue:1

    Topics: Adult; Aged; Anesthesia Recovery Period; Cognition; Conscious Sedation; Endoscopy, Gastrointestinal;

2011
Propofol in patients with cirrhosis and minimal hepatic encephalopathy.
    Journal of hepatology, 2011, Volume: 54, Issue:6

    Topics: Anesthetics, Intravenous; Endoscopy, Gastrointestinal; Hepatic Encephalopathy; Humans; Liver Cirrhos

2011
Propofol sedation during endoscopy in patients with cirrhosis, and utility of psychometric tests and critical flicker frequency in assessment of recovery from sedation.
    Endoscopy, 2011, Volume: 43, Issue:5

    Topics: Adult; Aged; Anesthesia Recovery Period; Cognition; Endoscopy, Gastrointestinal; Female; Flicker Fus

2011

Other Studies

6 other studies available for propofol and Encephalopathy, Hepatic

ArticleYear
Propofol alone prevents worsening hepatic encephalopathy rather than midazolam alone or combined sedation after esophagogastroduodenoscopy in compensated or decompensated cirrhotic patients.
    European journal of gastroenterology & hepatology, 2020, Volume: 32, Issue:8

    Topics: Conscious Sedation; Endoscopy, Digestive System; Hepatic Encephalopathy; Humans; Hypnotics and Sedat

2020
Deep sedation with propofol does not precipitate hepatic encephalopathy during elective upper endoscopy.
    Gastrointestinal endoscopy, 2009, Volume: 70, Issue:2

    Topics: Cohort Studies; Conscious Sedation; Elective Surgical Procedures; Endoscopy, Gastrointestinal; Femal

2009
Use of bispectral index monitoring for a patient with hepatic encephalopathy requiring living donor liver transplantation: a case report.
    Journal of anesthesia, 2011, Volume: 25, Issue:1

    Topics: Adult; Androstanols; Anesthesia, Intravenous; Anesthetics, Intravenous; Consciousness Monitors; Fent

2011
Functional abnormalities of the motor tract in the rat after portocaval anastomosis and after carbon tetrachloride induction of cirrhosis.
    Metabolic brain disease, 2006, Volume: 21, Issue:4

    Topics: Anastomosis, Surgical; Anesthetics, Intravenous; Animals; Carbon Tetrachloride; Disease Models, Anim

2006
Case presentation: fulminant hepatic failure.
    Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 1999, Volume: 5, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Death; Brain Edema; Female; Hepatic Encephalop

1999
Propofol to control intracranial pressure in fulminant hepatic failure.
    Transplantation proceedings, 2002, Volume: 34, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Female; Hepatic Encephalopathy; Humans; Intracranial Hypertensio

2002
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